PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14967028-0	2004	Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model.	Irinotecan	22-28	carboxylesterase 1	Homo sapiens	43-60	
14967028-1	2004	CPT-11 is a prodrug that is converted in vivo to the topoisomerase I poison SN-38 by carboxylesterases (CEs).	Irinotecan	0-6	carboxylesterase 1	Homo sapiens	85-102	
14967028-1	2004	CPT-11 is a prodrug that is converted in vivo to the topoisomerase I poison SN-38 by carboxylesterases (CEs).	Irinotecan	76-81	carboxylesterase 1	Homo sapiens	85-102	
14967028-3	2004	Despite extensive sequence homology, however, the human homologues of this protein, hCE1 and hiCE, metabolize CPT-11 with significantly lower efficiencies.	Irinotecan	110-116	carboxylesterase 1	Homo sapiens	84-88