PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14742323-0	2004	Activation of beta-catenin provides proliferative and invasive advantages in c-myc/TGF-alpha hepatocarcinogenesis promoted by phenobarbital.	Phenobarbital	126-139	transforming growth factor alpha	Mus musculus	83-92	
14742323-2	2004	Given that PB selectively promoted initiated cells harboring beta-catenin mutations during chemically induced hepatocarcinogenesis and that Wnt/beta-catenin signaling is involved in both anti-apoptotic and proliferative processes, we now have extended our analysis to investigate whether promotion by PB affects the occurrence of beta-catenin mutations in c-myc/TGF-alpha-driven tumors.	Phenobarbital	11-13	transforming growth factor alpha	Mus musculus	362-371	
14742323-3	2004	The frequency of beta-catenin activation as judged by somatic mutations and/or nuclear localization was significantly increased in hepatocellular carcinomas (HCCs) from c-myc/TGF-alpha mice treated with PB (15/28; 53.6%) as compared with that in control HCCs (2/28; 7.1%).	Phenobarbital	203-205	transforming growth factor alpha	Mus musculus	175-184	
14742323-8	2004	These findings show that PB treatment positively selects for a cell population displaying activation of beta-catenin in c-myc/TGF-alpha HCCs.	Phenobarbital	25-27	transforming growth factor alpha	Mus musculus	126-135