PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14688479-5	2003	In this study, we investigated the role of p53 and its downstream targets in bortezomib-induced apoptosis in HCT116 human colon cancer cells.	Bortezomib	77-87	tumor protein p53	Homo sapiens	43-46	
14688479-6	2003	We demonstrated that bortezomib induced p53, and activated its downstream genes p21, PUMA and Bax in a p53-dependent fashion.	Bortezomib	21-31	tumor protein p53	Homo sapiens	40-43	
14688479-6	2003	We demonstrated that bortezomib induced p53, and activated its downstream genes p21, PUMA and Bax in a p53-dependent fashion.	Bortezomib	21-31	tumor protein p53	Homo sapiens	103-106	
14688479-11	2003	These results indicate that p53 downstream targets can collectively modulate apoptotic response to bortezomib and other proteasome inhibitors.	Bortezomib	99-109	tumor protein p53	Homo sapiens	28-31