PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14681341-1 2004 The effect of renal insufficiency on the pharmacokinetics of etoricoxib, a selective inhibitor of cyclooxygenase-2, was examined in 23 patients with varying degrees of renal impairment (12 moderate [creatinine clearance between 30 and 50 mL/min/1.73 m2], 5 severe [creatinine clearance below 30 mL/min/1.73 m2], and 6 with end-stage renal disease requiring hemodialysis) following administration of single 120-mg oral doses of etoricoxib. Etoricoxib 61-71 prostaglandin-endoperoxide synthase 2 Homo sapiens 98-114