PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14633118-4 2003 The ability of MPO to generate hypochlorous acid/hypochlorite (HOCl/OCl-) from hydrogen peroxide in the presence of chloride ions is a unique and defining activity for this enzyme. Chlorides 116-124 myeloperoxidase Homo sapiens 15-18 14633118-5 2003 The MPO-hydrogen peroxide-chloride system leads to a variety of chlorinated protein and lipid adducts that in turn may cause dysfunction of cells in different compartments of the kidney. Chlorides 26-34 myeloperoxidase Homo sapiens 4-7 14633118-6 2003 The aim of this article is to cover and interpret some experimental and clinical aspects in glomerular and tubulointerstitial diseases in which the MPO-hydrogen peroxide-chloride system has been considered an important pathophysiologic factor in the progression but also the attenuation of experimental renal disease. Chlorides 170-178 myeloperoxidase Homo sapiens 148-151 14633118-8 2003 Specifically, the interaction of MPO with nitric oxide metabolism adds to the complexity of actions of oxidants and may help to explain bimodal partly detrimental partly beneficial effects of the MPO-hydrogen peroxide-chloride system in redox-modulated renal diseases. Chlorides 218-226 myeloperoxidase Homo sapiens 33-36 14633118-8 2003 Specifically, the interaction of MPO with nitric oxide metabolism adds to the complexity of actions of oxidants and may help to explain bimodal partly detrimental partly beneficial effects of the MPO-hydrogen peroxide-chloride system in redox-modulated renal diseases. Chlorides 218-226 myeloperoxidase Homo sapiens 196-199