PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1357223-0	1992	High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-beta.	Glucose	5-12	transforming growth factor, beta 1	Mus musculus	79-87	
1357223-4	1992	The early phase of glucose-induced proliferation was associated with increased expression of the immediate early genes c-myc and egr-1 as well as with induction of the S-phase related proliferating nuclear cell antigen (PCNA).	Glucose	19-26	early growth response 1	Mus musculus	129-134	
1357223-4	1992	The early phase of glucose-induced proliferation was associated with increased expression of the immediate early genes c-myc and egr-1 as well as with induction of the S-phase related proliferating nuclear cell antigen (PCNA).	Glucose	19-26	proliferating cell nuclear antigen	Mus musculus	220-224	
1357223-5	1992	Several lines of evidence indicated that the late phase of glucose-induced growth inhibition was mediated by the bioactivation of endogenous transforming growth factor beta (TGF-beta).	Glucose	59-66	transforming growth factor, beta 1	Mus musculus	174-182	
1357223-6	1992	Neutralizing antibody against TGF-beta prevented the late inhibitory effects of glucose on proliferation.	Glucose	80-87	transforming growth factor, beta 1	Mus musculus	30-38	
1357223-8	1992	Furthermore, Northern blot analysis revealed that TGF-beta 1 mRNA was induced by 450 mg/dl glucose in the medium after 48 to 72 hours, but not after 24 hours.	Glucose	91-98	transforming growth factor, beta 1	Mus musculus	50-60	
1357223-11	1992	However, the addition of neutralizing anti-TGF-beta antibody stimulated the progression of cells towards S-G2 in high glucose medium after 48 hours.	Glucose	118-125	transforming growth factor, beta 1	Mus musculus	43-51	
1357223-13	1992	This inhibition may be mediated by the glucose-induced synthesis and/or bioactivation of TGF-beta which can inhibit proliferation of mesangial cells in an autocrine fashion.	Glucose	39-46	transforming growth factor, beta 1	Mus musculus	89-97