PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1319834-0	1992	Retinoid antagonism of estrogen-responsive transforming growth factor alpha and pS2 gene expression in breast carcinoma cells.	Retinoids	0-8	tumor necrosis factor	Homo sapiens	43-75	
1319834-0	1992	Retinoid antagonism of estrogen-responsive transforming growth factor alpha and pS2 gene expression in breast carcinoma cells.	Retinoids	0-8	trefoil factor 1	Homo sapiens	80-83	
1319834-1	1992	Exposure of MCF-7 breast carcinoma cells to estradiol results in an increase in transforming growth factor alpha (TGF-alpha) synthesis and secretion.	Estradiol	44-53	tumor necrosis factor	Homo sapiens	80-112	
1319834-1	1992	Exposure of MCF-7 breast carcinoma cells to estradiol results in an increase in transforming growth factor alpha (TGF-alpha) synthesis and secretion.	Estradiol	44-53	transforming growth factor alpha	Homo sapiens	114-123	
1319834-2	1992	Since TGF-alpha is a potent inducer of proliferation in MCF-7 cells, the increase in TGF-alpha production by estradiol is thought to play an important role in the estrogen stimulation of growth of these cells.	Estradiol	109-118	transforming growth factor alpha	Homo sapiens	85-94	
1319834-4	1992	Addition of retinoic acid resulted in a greater than 70% inhibition of estradiol-induced TGF-alpha synthesis and secretion in MCF-7 cells.	Tretinoin	12-25	transforming growth factor alpha	Homo sapiens	89-98	
1319834-4	1992	Addition of retinoic acid resulted in a greater than 70% inhibition of estradiol-induced TGF-alpha synthesis and secretion in MCF-7 cells.	Estradiol	71-80	transforming growth factor alpha	Homo sapiens	89-98	
1319834-5	1992	The increase in TGF-alpha mRNA expression by estradiol was also inhibited by exposure of the cells to retinoic acid.	Tretinoin	102-115	transforming growth factor alpha	Homo sapiens	16-25	
1319834-6	1992	Pretreatment of the cells with retinoic acid for 24 or 72 h caused more than 50 and 90% inhibition, respectively, of the estradiol-enhanced expression of TGF-alpha mRNA.	Tretinoin	31-44	transforming growth factor alpha	Homo sapiens	154-163	
1319834-8	1992	Retinoic acid treatment suppressed by greater than 80% both the basal and estradiol-induced pS2 mRNA expression.	Tretinoin	0-13	trefoil factor 1	Homo sapiens	92-95	
1319834-8	1992	Retinoic acid treatment suppressed by greater than 80% both the basal and estradiol-induced pS2 mRNA expression.	Estradiol	74-83	trefoil factor 1	Homo sapiens	92-95	
1319834-9	1992	Retinoic acid modulation of the estrogen receptor gene mRNA was not responsible for the retinoic acid inhibition of the stimulation of pS2 and TGF-alpha gene expression by estradiol, since estrogen receptor gene expression was increased rather than decreased in the presence of retinoic acid.	Tretinoin	0-13	estrogen receptor 1	Homo sapiens	32-49	
1319834-12	1992	These results indicate that retinoic acid can inhibit estradiol-induced TGF-alpha and pS2 mRNA expression in MCF-7 cells.	Tretinoin	28-41	transforming growth factor alpha	Homo sapiens	72-81	
1319834-12	1992	These results indicate that retinoic acid can inhibit estradiol-induced TGF-alpha and pS2 mRNA expression in MCF-7 cells.	Tretinoin	28-41	trefoil factor 1	Homo sapiens	86-89	
1319834-12	1992	These results indicate that retinoic acid can inhibit estradiol-induced TGF-alpha and pS2 mRNA expression in MCF-7 cells.	Estradiol	54-63	transforming growth factor alpha	Homo sapiens	72-81	
1319834-12	1992	These results indicate that retinoic acid can inhibit estradiol-induced TGF-alpha and pS2 mRNA expression in MCF-7 cells.	Estradiol	54-63	trefoil factor 1	Homo sapiens	86-89	
1319834-13	1992	The suppression of TGF-alpha expression may represent one possible mechanism by which retinoic acid antagonizes the stimulation of MCF-7 proliferation by estradiol.	Estradiol	154-163	transforming growth factor alpha	Homo sapiens	19-28