PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1314698-4 1992 The antiproliferative effects of TNF on L-929 cells were inhibited by orthovanadate, an inhibitor of phosphotyrosine phosphatases, in a dose-dependent manner. Vanadates 70-83 tumor necrosis factor Mus musculus 33-36 1314698-5 1992 Okadaic acid, which is a specific inhibitor of phosphoserine- and phosphothreonine-specific phosphatases, also blocked the growth-inhibitory effects of TNF, suggesting that TNF may function through the activation of certain phosphatases. Okadaic Acid 0-12 tumor necrosis factor Homo sapiens 152-155 1314698-5 1992 Okadaic acid, which is a specific inhibitor of phosphoserine- and phosphothreonine-specific phosphatases, also blocked the growth-inhibitory effects of TNF, suggesting that TNF may function through the activation of certain phosphatases. Okadaic Acid 0-12 tumor necrosis factor Homo sapiens 173-176 1314698-5 1992 Okadaic acid, which is a specific inhibitor of phosphoserine- and phosphothreonine-specific phosphatases, also blocked the growth-inhibitory effects of TNF, suggesting that TNF may function through the activation of certain phosphatases. Phosphoserine 47-60 tumor necrosis factor Homo sapiens 152-155 1314698-5 1992 Okadaic acid, which is a specific inhibitor of phosphoserine- and phosphothreonine-specific phosphatases, also blocked the growth-inhibitory effects of TNF, suggesting that TNF may function through the activation of certain phosphatases. Phosphoserine 47-60 tumor necrosis factor Homo sapiens 173-176 1314698-8 1992 Cells were protected by orthovanadate from the cytotoxic effects of TNF even in the presence of actinomycin D or cycloheximide, thus indicating the lack of a requirement for de novo protein synthesis. Vanadates 24-37 tumor necrosis factor Homo sapiens 68-71