PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1312937-0	1992	Tumor necrosis factor-mediated cell lysis in vitro: relationship to cAMP accumulation and guanine nucleotide-binding proteins.	Cyclic AMP	68-72	tumor necrosis factor	Homo sapiens	0-21	
1312937-0	1992	Tumor necrosis factor-mediated cell lysis in vitro: relationship to cAMP accumulation and guanine nucleotide-binding proteins.	Guanine Nucleotides	90-108	tumor necrosis factor	Homo sapiens	0-21	
1312937-1	1992	We have investigated the modulation of tumor necrosis factor (TNF)-mediated tumor cell lysis by cAMP.	Cyclic AMP	96-100	tumor necrosis factor	Homo sapiens	39-60	
1312937-1	1992	We have investigated the modulation of tumor necrosis factor (TNF)-mediated tumor cell lysis by cAMP.	Cyclic AMP	96-100	tumor necrosis factor	Homo sapiens	62-65	
1312937-4	1992	To study the relationship between TNF-mediated cell lysis and cAMP accumulation, cAMP measurement was performed following TNF treatment.	Cyclic AMP	62-66	tumor necrosis factor	Homo sapiens	34-37	
1312937-6	1992	Experiments in which cells were exposed to forskolin revealed that this cAMP elevating drug was efficient in enhancing the sensitivity to TNF of MCF7 cell line.	Colforsin	43-52	tumor necrosis factor	Homo sapiens	138-141	
1312937-6	1992	Experiments in which cells were exposed to forskolin revealed that this cAMP elevating drug was efficient in enhancing the sensitivity to TNF of MCF7 cell line.	Cyclic AMP	72-76	tumor necrosis factor	Homo sapiens	138-141	
1312937-7	1992	This potentiating effect of forskolin was maximal for suboptimal concentrations of TNF (10 ng/ml), reaching up to 100% when forskolin was added at 100 microM.	Colforsin	28-37	tumor necrosis factor	Homo sapiens	83-86	
1312937-7	1992	This potentiating effect of forskolin was maximal for suboptimal concentrations of TNF (10 ng/ml), reaching up to 100% when forskolin was added at 100 microM.	Colforsin	124-133	tumor necrosis factor	Homo sapiens	83-86	
1312937-8	1992	However, co-stimulating with forskolin of either MDA MB 231 or a TNF-resistant MCF7 clone (MCF7-R-A1) did not induce any reversal of resistance to TNF.	Colforsin	29-38	tumor necrosis factor	Homo sapiens	65-68	
1312937-12	1992	In contrast, pertussis toxin-catalyzed ADP ribosylation experiments suggest a functional coupling of TNF receptors to a 40-kDa pertussis toxin-sensitive G-protein in the TNF-sensitive MCF78 cell line but not in the TNF-resistant MDA MB 231 cell line.	Adenosine Diphosphate	39-42	tumor necrosis factor	Homo sapiens	101-104	
1312937-12	1992	In contrast, pertussis toxin-catalyzed ADP ribosylation experiments suggest a functional coupling of TNF receptors to a 40-kDa pertussis toxin-sensitive G-protein in the TNF-sensitive MCF78 cell line but not in the TNF-resistant MDA MB 231 cell line.	Adenosine Diphosphate	39-42	tumor necrosis factor	Homo sapiens	170-173	
1312937-12	1992	In contrast, pertussis toxin-catalyzed ADP ribosylation experiments suggest a functional coupling of TNF receptors to a 40-kDa pertussis toxin-sensitive G-protein in the TNF-sensitive MCF78 cell line but not in the TNF-resistant MDA MB 231 cell line.	Adenosine Diphosphate	39-42	tumor necrosis factor	Homo sapiens	170-173	
1312937-13	1992	Taken together, these data indicate that cAMP might play a role in TNF-mediated cell lysis and are in support of the involvement of a pertussis toxin-sensitive G-protein in TNF-mediated MCF7 cells lysis.	Cyclic AMP	41-45	tumor necrosis factor	Homo sapiens	67-70	
1312937-13	1992	Taken together, these data indicate that cAMP might play a role in TNF-mediated cell lysis and are in support of the involvement of a pertussis toxin-sensitive G-protein in TNF-mediated MCF7 cells lysis.	Cyclic AMP	41-45	tumor necrosis factor	Homo sapiens	173-176