PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1290725-0 1992 Effect of pyridoxine on tumor necrosis factor activities in vitro. Pyridoxine 10-20 tumor necrosis factor Homo sapiens 24-45 1290725-2 1992 In this study we show that the naturally occurring vitamin B6 compound, pyridoxine, enhances TNF-induced cytolysis of three subclones of a mouse fibrosarcoma cell line (WEHI 164). Vitamin B 6 51-61 tumor necrosis factor Mus musculus 93-96 1290725-2 1992 In this study we show that the naturally occurring vitamin B6 compound, pyridoxine, enhances TNF-induced cytolysis of three subclones of a mouse fibrosarcoma cell line (WEHI 164). Pyridoxine 72-82 tumor necrosis factor Mus musculus 93-96 1290725-3 1992 The degree of pyridoxine-induced enhancement of TNF cytotoxicity seems to be dependent on the cells sensitivity to TNF, as the enhancement was much more pronounced in the relatively TNF resistant subclone act-R(cl.12)-WEHI 164, than in the very TNF sensitive subclone WEHI 164 clone 13. Pyridoxine 14-24 tumor necrosis factor Homo sapiens 48-51 1290725-3 1992 The degree of pyridoxine-induced enhancement of TNF cytotoxicity seems to be dependent on the cells sensitivity to TNF, as the enhancement was much more pronounced in the relatively TNF resistant subclone act-R(cl.12)-WEHI 164, than in the very TNF sensitive subclone WEHI 164 clone 13. Pyridoxine 14-24 tumor necrosis factor Homo sapiens 115-118 1290725-3 1992 The degree of pyridoxine-induced enhancement of TNF cytotoxicity seems to be dependent on the cells sensitivity to TNF, as the enhancement was much more pronounced in the relatively TNF resistant subclone act-R(cl.12)-WEHI 164, than in the very TNF sensitive subclone WEHI 164 clone 13. Pyridoxine 14-24 tumor necrosis factor Homo sapiens 115-118 1290725-3 1992 The degree of pyridoxine-induced enhancement of TNF cytotoxicity seems to be dependent on the cells sensitivity to TNF, as the enhancement was much more pronounced in the relatively TNF resistant subclone act-R(cl.12)-WEHI 164, than in the very TNF sensitive subclone WEHI 164 clone 13. Pyridoxine 14-24 tumor necrosis factor Homo sapiens 115-118 1290725-4 1992 Furthermore, our study shows that pyridoxine, in contrast to its enhancing effect on TNF-induced cytotoxicity, rather inhibits TNF-induced growth of human FS-4 fibroblasts. Pyridoxine 34-44 tumor necrosis factor Homo sapiens 85-88 1290725-4 1992 Furthermore, our study shows that pyridoxine, in contrast to its enhancing effect on TNF-induced cytotoxicity, rather inhibits TNF-induced growth of human FS-4 fibroblasts. Pyridoxine 34-44 tumor necrosis factor Homo sapiens 127-130