PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12899610-0	2003	Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry.	Niacinamide	19-31	sirtuin 1	Mus musculus	0-4	
12899610-1	2003	Life span regulation and inhibition of gene silencing in yeast have been linked to nicotinamide effects on Sir2 enzymes.	Niacinamide	83-95	sirtuin 1	Mus musculus	107-111	
12899610-2	2003	The Sir2 enzymes are NAD(+)-dependent protein deacetylases that influence gene expression by forming deacetylated proteins, nicotinamide and 2"-O-acetyl-ADPR.	Niacinamide	124-136	sirtuin 1	Mus musculus	4-8	
12899610-5	2003	Nicotinamide switching is quantitated for the Sir2s from Archeaglobus fulgidus (Sir2Af2), Saccharomyces cerevisiae (Sir2p), and mouse (Sir2alpha).	Niacinamide	0-12	sirtuin 1	Mus musculus	135-144	
12899610-11	2003	Nicotinamide switching supports the previously proposed Sir2 catalytic mechanism and the existence of a 1"-O-peptidyl-ADPR.Sir2 intermediate.	Niacinamide	0-12	sirtuin 1	Mus musculus	56-60	
12899610-11	2003	Nicotinamide switching supports the previously proposed Sir2 catalytic mechanism and the existence of a 1"-O-peptidyl-ADPR.Sir2 intermediate.	Niacinamide	0-12	sirtuin 1	Mus musculus	123-127