PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1284126-4	1992	In contrast, MMP-3, MMP-9 and TIMP-1 activities were markedly stimulated by TPA in most of the tumor cell lines and human umbilical vein endothelial cells (HUVEC), whereas the fibroblast lines were minimally stimulated or unresponsive to TPA.	Tetradecanoylphorbol Acetate	76-79	matrix metallopeptidase 3	Homo sapiens	13-18	
1284126-4	1992	In contrast, MMP-3, MMP-9 and TIMP-1 activities were markedly stimulated by TPA in most of the tumor cell lines and human umbilical vein endothelial cells (HUVEC), whereas the fibroblast lines were minimally stimulated or unresponsive to TPA.	Tetradecanoylphorbol Acetate	76-79	matrix metallopeptidase 9	Homo sapiens	20-25	
1284126-4	1992	In contrast, MMP-3, MMP-9 and TIMP-1 activities were markedly stimulated by TPA in most of the tumor cell lines and human umbilical vein endothelial cells (HUVEC), whereas the fibroblast lines were minimally stimulated or unresponsive to TPA.	Tetradecanoylphorbol Acetate	76-79	TIMP metallopeptidase inhibitor 1	Homo sapiens	30-36	
1284126-9	1992	TPA-mediated stimulation of MMP-1 was similar to that of MMP-3 and MMP-9.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 1	Homo sapiens	28-33	
1284126-10	1992	Exceptions were the fibroblast cell lines which showed either a much more marked mRNA response of MMP-9 to TPA than observed at protein level, or a high constitutive MMP-9 mRNA when MMP-9 activity was not detectable by zymography.	Tetradecanoylphorbol Acetate	107-110	matrix metallopeptidase 9	Homo sapiens	98-103	
1284126-11	1992	TPA-mediated stimulation of MMP-9 and TIMP-1 activity was blocked by staurosporine, an inhibitor of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 9	Homo sapiens	28-33	
1284126-11	1992	TPA-mediated stimulation of MMP-9 and TIMP-1 activity was blocked by staurosporine, an inhibitor of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	0-3	TIMP metallopeptidase inhibitor 1	Homo sapiens	38-44	
1284126-11	1992	TPA-mediated stimulation of MMP-9 and TIMP-1 activity was blocked by staurosporine, an inhibitor of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	0-3	proline rich transmembrane protein 2	Homo sapiens	100-116	
1284126-11	1992	TPA-mediated stimulation of MMP-9 and TIMP-1 activity was blocked by staurosporine, an inhibitor of protein kinase C (PKC).	Tetradecanoylphorbol Acetate	0-3	proline rich transmembrane protein 2	Homo sapiens	118-121	
1284126-11	1992	TPA-mediated stimulation of MMP-9 and TIMP-1 activity was blocked by staurosporine, an inhibitor of protein kinase C (PKC).	Staurosporine	69-82	matrix metallopeptidase 9	Homo sapiens	28-33	
1284126-11	1992	TPA-mediated stimulation of MMP-9 and TIMP-1 activity was blocked by staurosporine, an inhibitor of protein kinase C (PKC).	Staurosporine	69-82	TIMP metallopeptidase inhibitor 1	Homo sapiens	38-44	
1284126-11	1992	TPA-mediated stimulation of MMP-9 and TIMP-1 activity was blocked by staurosporine, an inhibitor of protein kinase C (PKC).	Staurosporine	69-82	proline rich transmembrane protein 2	Homo sapiens	100-116	
1284126-11	1992	TPA-mediated stimulation of MMP-9 and TIMP-1 activity was blocked by staurosporine, an inhibitor of protein kinase C (PKC).	Staurosporine	69-82	proline rich transmembrane protein 2	Homo sapiens	118-121	
1284126-12	1992	A non-PKC-activating phorbol ester, 4 alpha-phorbol-12,13-didecanoate, did not stimulate MMP-9 and TIMP-1 activity.	Phorbol Esters	21-34	proline rich transmembrane protein 2	Homo sapiens	6-9	
1284126-13	1992	TPA treatment caused the increased expression of c-fos containing AP-1-specific binding activity in selected tumor cell lines.	Tetradecanoylphorbol Acetate	0-3	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	49-54	
1284126-14	1992	This activity was maximal at 6 h. An association was observed between AP-1 binding activity and increased expression of MMP-1, MMP-3 and MMP-9, which possess TPA-responsive elements (TRE).	Tetradecanoylphorbol Acetate	158-161	matrix metallopeptidase 1	Homo sapiens	120-125	
1284126-14	1992	This activity was maximal at 6 h. An association was observed between AP-1 binding activity and increased expression of MMP-1, MMP-3 and MMP-9, which possess TPA-responsive elements (TRE).	Tetradecanoylphorbol Acetate	158-161	matrix metallopeptidase 3	Homo sapiens	127-132	
1284126-14	1992	This activity was maximal at 6 h. An association was observed between AP-1 binding activity and increased expression of MMP-1, MMP-3 and MMP-9, which possess TPA-responsive elements (TRE).	Tetradecanoylphorbol Acetate	158-161	matrix metallopeptidase 9	Homo sapiens	137-142	
1284126-15	1992	TPA-sensitive MMPs and TIMP-1 were variably stimulated by biologically relevant cytokines, such as IL-1 and TNF-alpha.	Tetradecanoylphorbol Acetate	0-3	matrix metallopeptidase 1	Homo sapiens	14-18	
1284126-15	1992	TPA-sensitive MMPs and TIMP-1 were variably stimulated by biologically relevant cytokines, such as IL-1 and TNF-alpha.	Tetradecanoylphorbol Acetate	0-3	interleukin 1 alpha	Homo sapiens	99-103	
1284126-15	1992	TPA-sensitive MMPs and TIMP-1 were variably stimulated by biologically relevant cytokines, such as IL-1 and TNF-alpha.	Tetradecanoylphorbol Acetate	0-3	tumor necrosis factor	Homo sapiens	108-117