PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12805076-7	2003	In addition, CRP was frequently colocalized with p22phox, an essential component of NADH/NADPH oxidase, which is an important source of ROS in vasculature.	Reactive Oxygen Species	136-139	C-reactive protein	Homo sapiens	13-16	
12805076-7	2003	In addition, CRP was frequently colocalized with p22phox, an essential component of NADH/NADPH oxidase, which is an important source of ROS in vasculature.	Reactive Oxygen Species	136-139	cytochrome b-245 alpha chain	Homo sapiens	49-56	
12805076-8	2003	Moreover, the incubation of cultured CASMCs with CRP resulted in the enhanced p22phox protein expression and in the generation of intracellular ROS.	casmcs	37-43	C-reactive protein	Homo sapiens	49-52	
12805076-8	2003	Moreover, the incubation of cultured CASMCs with CRP resulted in the enhanced p22phox protein expression and in the generation of intracellular ROS.	casmcs	37-43	cytochrome b-245 alpha chain	Homo sapiens	78-85	
12805076-8	2003	Moreover, the incubation of cultured CASMCs with CRP resulted in the enhanced p22phox protein expression and in the generation of intracellular ROS.	Reactive Oxygen Species	144-147	C-reactive protein	Homo sapiens	49-52	
12805076-9	2003	CONCLUSIONS: The expression of CRP in coronary arteries was associated with histological and clinical features of vulnerable plaque, and it had a prooxidative effect on cultured CASMCs, suggesting that it might play a crucial role in plaque instability and in the pathogenesis of acute coronary syndrome via its prooxidative effect.	casmcs	178-184	C-reactive protein	Homo sapiens	31-34