PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12756251-8 2003 To investigate the specific role of dimerization in the internalization process of GPCRs, we generated a fusion protein of hPAFR and bacterial DNA gyrase B (GyrB), dimerized through the addition of coumermycin. coumermycin 198-209 platelet activating factor receptor Homo sapiens 123-128 12756251-9 2003 We found that dimerization potentiates PAF-induced internalization of hPAFR-GyrB in Chinese hamster ovary cells stably expressing c-Myc-hPAFR-GyrB. Platelet Activating Factor 39-42 platelet activating factor receptor Homo sapiens 70-75 12756251-9 2003 We found that dimerization potentiates PAF-induced internalization of hPAFR-GyrB in Chinese hamster ovary cells stably expressing c-Myc-hPAFR-GyrB. Platelet Activating Factor 39-42 platelet activating factor receptor Homo sapiens 136-141 12756251-11 2003 Moreover, the protein kinase C inhibitors staurosporine and GF109203X blocked the coumermycin-induced desensitization of hPAFR-GyrB, suggesting the implication of protein kinase C in the molecular mechanism mediating the agonist-independent desensitization of the receptor. Staurosporine 42-55 platelet activating factor receptor Homo sapiens 121-126 12756251-11 2003 Moreover, the protein kinase C inhibitors staurosporine and GF109203X blocked the coumermycin-induced desensitization of hPAFR-GyrB, suggesting the implication of protein kinase C in the molecular mechanism mediating the agonist-independent desensitization of the receptor. bisindolylmaleimide I 60-69 platelet activating factor receptor Homo sapiens 121-126 12756251-11 2003 Moreover, the protein kinase C inhibitors staurosporine and GF109203X blocked the coumermycin-induced desensitization of hPAFR-GyrB, suggesting the implication of protein kinase C in the molecular mechanism mediating the agonist-independent desensitization of the receptor. coumermycin 82-93 platelet activating factor receptor Homo sapiens 121-126