PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12752443-0	2003	Co-operation of domain-binding and calcium-binding sites in the activation of gelsolin.	Calcium	35-42	gelsolin	Homo sapiens	78-86	
12752443-1	2003	Gelsolin is an abundant calcium dependent actin filament severing and capping protein.	Calcium	24-31	gelsolin	Homo sapiens	0-8	
12752443-3	2003	It is generally held that a "helical-latch" at the C-terminus of gelsolin"s domain 6 (G6), binds domain 2 (G2) to keep gelsolin in the calcium-free compact state, and that the crutial calcium binding site(s) reside in the C-terminal half of gelsolin perhaps involving the C-terminal helix itself has to be bound to release this latch.	Calcium	135-142	gelsolin	Homo sapiens	65-73	
12752443-3	2003	It is generally held that a "helical-latch" at the C-terminus of gelsolin"s domain 6 (G6), binds domain 2 (G2) to keep gelsolin in the calcium-free compact state, and that the crutial calcium binding site(s) reside in the C-terminal half of gelsolin perhaps involving the C-terminal helix itself has to be bound to release this latch.	Calcium	184-191	gelsolin	Homo sapiens	65-73	
12752443-6	2003	It is known that the activation of gelsolin involves multiple calcium binding events (around 6) the first of which (in G6) may release the latch.	Calcium	62-69	gelsolin	Homo sapiens	35-43	
12752443-8	2003	Additional calcium binding in other domains then result in the complete opening and activation of the gelsolin molecule.	Calcium	11-18	gelsolin	Homo sapiens	102-110