PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12601049-0 2003 Subconjunctival nano- and microparticles sustain retinal delivery of budesonide, a corticosteroid capable of inhibiting VEGF expression. Budesonide 69-79 vascular endothelial growth factor A Homo sapiens 120-124 12601049-1 2003 PURPOSE: The purpose of this study was to determine whether budesonide inhibits expression of vascular endothelial growth factor (VEGF) in a retinal pigment epithelial cell line (ARPE-19) and to determine whether subconjunctivally administered budesonide nano- and microparticles sustain retinal drug levels. Budesonide 60-70 vascular endothelial growth factor A Homo sapiens 94-128 12601049-1 2003 PURPOSE: The purpose of this study was to determine whether budesonide inhibits expression of vascular endothelial growth factor (VEGF) in a retinal pigment epithelial cell line (ARPE-19) and to determine whether subconjunctivally administered budesonide nano- and microparticles sustain retinal drug levels. Budesonide 60-70 vascular endothelial growth factor A Homo sapiens 130-134 12601049-6 2003 RESULTS: At concentrations devoid of cytotoxicity, budesonide inhibited VEGF secretion as well as mRNA expression in ARPE-19 cells in a dose-dependent manner. Budesonide 51-61 vascular endothelial growth factor A Homo sapiens 72-76 12601049-7 2003 RU486 treatment prevented budesonide-mediated inhibition of VEGF secretion and VEGF mRNA expression. Budesonide 26-36 vascular endothelial growth factor A Homo sapiens 60-64 12601049-7 2003 RU486 treatment prevented budesonide-mediated inhibition of VEGF secretion and VEGF mRNA expression. Budesonide 26-36 vascular endothelial growth factor A Homo sapiens 79-83 12601049-10 2003 CONCLUSIONS: Budesonide is capable of inhibiting VEGF expression through glucocorticoid receptor activity. Budesonide 13-23 vascular endothelial growth factor A Homo sapiens 49-53