PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12504922-0	2002	Regulation of Akt and glycogen synthase kinase-3 beta phosphorylation by sodium valproate and lithium.	Valproic Acid	73-89	glycogen synthase kinase 3 beta	Homo sapiens	22-53	
12504922-1	2002	This study tested if sodium valproate or lithium, two agents used to treat bipolar mood disorder, altered the regulatory phosphorylations of Akt or glycogen synthase kinase-3beta (GSK3beta) in human neuroblastoma SH-SY5Y cells.	Valproic Acid	21-37	glycogen synthase kinase 3 beta	Homo sapiens	148-178	
12504922-1	2002	This study tested if sodium valproate or lithium, two agents used to treat bipolar mood disorder, altered the regulatory phosphorylations of Akt or glycogen synthase kinase-3beta (GSK3beta) in human neuroblastoma SH-SY5Y cells.	Valproic Acid	21-37	glycogen synthase kinase 3 beta	Homo sapiens	180-188	
12504922-2	2002	Treatment with sodium valproate caused a gradual but relatively large increase in the activation-associated phosphorylation of Akt on Ser-473, and a similarly gradual but more modest increase in the inhibition-associated phosphorylation of GSK3beta on Ser-9.	Valproic Acid	15-31	glycogen synthase kinase 3 beta	Homo sapiens	240-248	
12504922-3	2002	Two other inhibitors of histone deacetylase, a recently identified target of sodium valproate, also caused gradual increases in the phosphorylation of Akt and GSK3beta.	Valproic Acid	77-93	glycogen synthase kinase 3 beta	Homo sapiens	159-167	
12504922-5	2002	These results identify novel effects of sodium valproate on the Akt/GSK3beta signaling pathway, indicating that histone deacetylase inhibition is linked to activation of Akt, and show that two anti-bipolar agents have a common action, the increased inhibitory phosphorylation of Ser-9-GSK3beta.	Valproic Acid	40-56	glycogen synthase kinase 3 beta	Homo sapiens	68-76	
12504922-5	2002	These results identify novel effects of sodium valproate on the Akt/GSK3beta signaling pathway, indicating that histone deacetylase inhibition is linked to activation of Akt, and show that two anti-bipolar agents have a common action, the increased inhibitory phosphorylation of Ser-9-GSK3beta.	Valproic Acid	40-56	glycogen synthase kinase 3 beta	Homo sapiens	285-293