PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12444898-1 2002 BACKGROUND: Various clinical and experimental findings support the concept that human chorionic gonadotropin (hCG) can stimulate iodide uptake in thyroid cells. Iodides 129-135 chorionic gonadotropin subunit beta 5 Homo sapiens 110-113 12444898-2 2002 DESIGN: We investigated the molecular mechanisms underlying the effects of hCG on iodide uptake, and particularly its action on the expression of Na+/I- symporter (NIS) mRNA and protein. Iodides 82-88 chorionic gonadotropin subunit beta 5 Homo sapiens 75-78 12444898-5 2002 RESULTS: Iodide uptake was increased by hCG in a dose- and time-dependent manner: maximal effects were observed after 72 h of stimulation. Iodides 9-15 chorionic gonadotropin subunit beta 5 Homo sapiens 40-43 12444898-9 2002 CONCLUSION: Our data demonstrated that hCG stimulates iodide uptake in FRTL-5 cells by increasing NIS mRNA and protein levels. Iodides 54-60 chorionic gonadotropin subunit beta 5 Homo sapiens 39-42