PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12021185-5 2002 Iodide accumulation increased after 2-h exposure to 5 IU/ml hCG, to 6-fold over the basal level after 8 h. This effect was reproduced using forskolin, the cAMP analog (Bu)(2)-cAMP, and phorbol acetate. Iodides 0-6 chorionic gonadotropin subunit beta 5 Homo sapiens 60-63 12021185-4 2002 Functional analysis clearly showed that Jar cells are able to concentrate iodide in presence of hCG. Iodides 74-80 chorionic gonadotropin subunit beta 5 Homo sapiens 96-99 12021185-7 2002 In conclusion, our data demonstrate that 1) NIS is expressed in JAr cells; 2) iodide transport in JAr cells is regulated by hCG and by cAMP-dependent and -independent mechanisms; 3) the stimulation of iodide uptake is due to an increase in both NIS mRNA and protein levels; and 4) JAr cells may represent an excellent in vitro model suitable to analyze the molecular mechanisms involved in iodide transport from mother to fetus. Iodides 78-84 chorionic gonadotropin subunit beta 5 Homo sapiens 124-127