PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11782484-0 2002 Plasmin reduction by phosphoglycerate kinase is a thiol-independent process. Sulfhydryl Compounds 50-55 plasminogen Homo sapiens 0-7 11782484-7 2002 Alkylation/oxidation of Cys-379 and -380 by four different thiol-reactive compounds reduced plasmin reductase activity to 7--35% of control. Sulfhydryl Compounds 59-64 plasminogen Homo sapiens 92-99 11782484-10 2002 In summary, reduction of plasmin by PGK is a thiol-independent process, although either alkylation/oxidation of the fast-reacting Cys near the hinge or hinge bending conformational change in PGK perturbs plasmin reduction by PGK, perhaps by obstructing the interaction of plasmin with PGK or perturbing conformational changes in PGK required for plasmin reduction. Sulfhydryl Compounds 45-50 plasminogen Homo sapiens 25-32