PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11550089-0 2001 Extended polyglutamine selectively interacts with caspase-8 and -10 in nuclear aggregates. polyglutamine 9-22 caspase 8 Homo sapiens 50-67 11550089-3 2001 We and others previously demonstrated that caspase-8 was activated by proteolysis in association with the expression of extended polyglutamine. polyglutamine 129-142 caspase 8 Homo sapiens 43-52 11550089-6 2001 Caspase-8 and -10 were recruited into nuclear aggregates of extended polyglutamine, where at least a fraction of these caspases was converted to the activated forms. polyglutamine 69-82 caspase 8 Homo sapiens 0-17 11550089-7 2001 Caspase-8 and -10 were co-immunoprecipitated with polyglutamine only when the polyglutamine was pathologically extended, whereas caspase-2, -3, -6, -7 and -9 were not co-immunoprecipitated with polyglutamine regardless of its size. polyglutamine 50-63 caspase 8 Homo sapiens 0-17 11550089-7 2001 Caspase-8 and -10 were co-immunoprecipitated with polyglutamine only when the polyglutamine was pathologically extended, whereas caspase-2, -3, -6, -7 and -9 were not co-immunoprecipitated with polyglutamine regardless of its size. polyglutamine 78-91 caspase 8 Homo sapiens 0-17 11550089-7 2001 Caspase-8 and -10 were co-immunoprecipitated with polyglutamine only when the polyglutamine was pathologically extended, whereas caspase-2, -3, -6, -7 and -9 were not co-immunoprecipitated with polyglutamine regardless of its size. polyglutamine 78-91 caspase 8 Homo sapiens 0-17 11550089-8 2001 A dominant-negative form of caspase-8 with a mutation at the catalytic cysteine residue inhibited polyglutamine-mediated nuclear apoptotic phenotype. polyglutamine 98-111 caspase 8 Homo sapiens 28-37