PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11533665-3 2001 Here we show that this complex is required for phosphorylation and activation of the Rad53 and Chk1 checkpoint kinases specifically in response to DSBs. dsbs 147-151 checkpoint kinase 2 Homo sapiens 85-90 11533665-3 2001 Here we show that this complex is required for phosphorylation and activation of the Rad53 and Chk1 checkpoint kinases specifically in response to DSBs. dsbs 147-151 checkpoint kinase 1 Homo sapiens 95-99 11533665-7 2001 Thus, the integrity of the Mre11/Rad50/Xrs2 complex is specifically required for checkpoint activation after the formation of DSBs. dsbs 126-130 MRE11 homolog, double strand break repair nuclease Homo sapiens 27-32 11533665-7 2001 Thus, the integrity of the Mre11/Rad50/Xrs2 complex is specifically required for checkpoint activation after the formation of DSBs. dsbs 126-130 RAD50 double strand break repair protein Homo sapiens 33-38 11533665-7 2001 Thus, the integrity of the Mre11/Rad50/Xrs2 complex is specifically required for checkpoint activation after the formation of DSBs. dsbs 126-130 Xrs2p Saccharomyces cerevisiae S288C 39-43