PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11494044-3	2001	In the present study, we have examined the effect of methylmethane sulfonate (MMS) to HCT-116 human colon cancer cells on the phosphorylation of p53.	Methyl Methanesulfonate	53-76	tumor protein p53	Homo sapiens	145-148	
11494044-3	2001	In the present study, we have examined the effect of methylmethane sulfonate (MMS) to HCT-116 human colon cancer cells on the phosphorylation of p53.	Methyl Methanesulfonate	78-81	tumor protein p53	Homo sapiens	145-148	
11494044-4	2001	Results show that p53 protein becomes phosphorylated at serine 15 (Ser15) and Ser392 residues after treatment with MMS in a time-dependent manner.	Methyl Methanesulfonate	115-118	tumor protein p53	Homo sapiens	18-21	
11494044-5	2001	Increased levels of phospho-p53(Ser15) and phospho-p53(Ser392) were maintained up to 50 h of the MMS treatment.	Methyl Methanesulfonate	97-100	tumor protein p53	Homo sapiens	28-31	
11494044-5	2001	Increased levels of phospho-p53(Ser15) and phospho-p53(Ser392) were maintained up to 50 h of the MMS treatment.	Methyl Methanesulfonate	97-100	tumor protein p53	Homo sapiens	51-54	
11494044-6	2001	We also examined the involvement of probable kinase(s), which could be responsible for MMS-induced phosphorylation of p53 at Ser15 and Ser392.	Methyl Methanesulfonate	87-90	tumor protein p53	Homo sapiens	118-121	
11494044-7	2001	In vitro phosphorylation assay, carried out with the immunoprecipates of MMS-treated cells, showed an increased phosphorylation of p53 by c-Jun kinase 1 (JNK1) at early time points (2.5 h).	Methyl Methanesulfonate	73-76	tumor protein p53	Homo sapiens	131-134	
11494044-10	2001	The MMS-induced phosphorylation of p53 correlates with our previous findings of p53"s ability for increased sequence-specific DNA-binding and transcriptional activity in the cells treated with DNA alkylating agents.	Methyl Methanesulfonate	4-7	tumor protein p53	Homo sapiens	35-38	
11494044-10	2001	The MMS-induced phosphorylation of p53 correlates with our previous findings of p53"s ability for increased sequence-specific DNA-binding and transcriptional activity in the cells treated with DNA alkylating agents.	Methyl Methanesulfonate	4-7	tumor protein p53	Homo sapiens	80-83