PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11409940-7 2001 Cytotoxicity in BEC preparations (9/13) was also induced by the supernatants of human liver microsomes and of recombinant human cytochrome P450 (CYP)3A4 preincubated with flucloxacillin (500 mg/L). Floxacillin 171-185 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 128-152 11409940-12 2001 In conclusion, hepatocytes mainly via CYP3A4 activity, generate flucloxacillin metabolite(s) including 5"-hydroxymethylflucloxacillin that may induce cytotoxicity in susceptible BEC. Floxacillin 64-78 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 38-44