PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11336536-0	2001	Histamine-induced production of interleukin-6 and interleukin-8 by human coronary artery endothelial cells is enhanced by endotoxin and tumor necrosis factor-alpha.	Histamine	0-9	interleukin 6	Homo sapiens	32-45	
11336536-1	2001	In this study, we tested the synergy between histamine and LPS, and histamine and TNF-alpha, on endothelial cell production of interleukin-6 (IL-6), interleukin-8 (IL-8), and monocyte chemoattractant protein-1 (MCP-1).	Histamine	45-54	interleukin 6	Homo sapiens	127-140	
11336536-1	2001	In this study, we tested the synergy between histamine and LPS, and histamine and TNF-alpha, on endothelial cell production of interleukin-6 (IL-6), interleukin-8 (IL-8), and monocyte chemoattractant protein-1 (MCP-1).	Histamine	68-77	interleukin 6	Homo sapiens	127-140	
11336536-4	2001	The incubation of HCAEC with histamine resulted in low level induction of IL-6 and IL-8 production, which was dose-dependent and attained a plateau at a concentration of 10 microM.	Histamine	29-38	interleukin 6	Homo sapiens	74-78	
11336536-7	2001	In the presence of all stimulatory concentrations of LPS and TNF-alpha tested, histamine was shown to further enhance IL-6 and IL-8 production.	Histamine	79-88	interleukin 6	Homo sapiens	118-122	
11336536-10	2001	Since both LPS and TNF-alpha potentiated histamine-induced cytokine production, it is possible that these activators stimulate H-1 receptor expression and/or augment the signal transduction pathways leading to the expression of IL-6 and IL-8.	Histamine	41-50	interleukin 6	Homo sapiens	228-232