PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11286989-5 2001 In addition, genistein enhanced the expression of the cell cycle inhibitor p21(waf/cip1) by 10- to 15-fold, increased p21(waf/cip1) association with Cdc2 by 2-fold, and increased the expression of the tumor suppressor p53 by 2.8-fold. Genistein 13-22 H3 histone pseudogene 16 Homo sapiens 75-78 11286989-5 2001 In addition, genistein enhanced the expression of the cell cycle inhibitor p21(waf/cip1) by 10- to 15-fold, increased p21(waf/cip1) association with Cdc2 by 2-fold, and increased the expression of the tumor suppressor p53 by 2.8-fold. Genistein 13-22 H3 histone pseudogene 16 Homo sapiens 118-121 11286989-8 2001 From these results, we conclude that genistein inhibits the growth of nonneoplastic MCF-10F human breast cells by preventing the G2/M phase transition, induces the expression of the cell cycle inhibitor p21(waf/cip1) as well as its interaction with Cdc2, and inhibits the activity of Cdc2 in a phosphorylation-related manner. Genistein 37-46 H3 histone pseudogene 16 Homo sapiens 203-206