PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11260059-0 2001 Myristoylated alanine-rich C kinase substrate phosphorylation is involved in thrombin-induced serotonin release from platelets. Serotonin 94-103 coagulation factor II, thrombin Homo sapiens 77-85 11260059-1 2001 Stimulation of platelets by thrombin induces protein kinase C (PKC) activation, phosphorylation of pleckstrin, aggregation and serotonin release. Serotonin 127-136 coagulation factor II, thrombin Homo sapiens 28-36 11260059-2 2001 Here, we demonstrate that, in human platelets, thrombin stimulation also induced phosphorylation of the myristoylated alanine-rich C kinase substrate (MARCKS) and serotonin release in intact and digitonin-permeabilized platelets. Serotonin 163-172 coagulation factor II, thrombin Homo sapiens 47-55 11260059-4 2001 MARCKS phosphorylation and serotonin release in response to increasing concentrations of thrombin have a similar EC50 and time course and, in permeabilized platelets, peptide MPSD, with an amino acid sequence corresponding to the phosphorylation site domain of MARCKS, blocked both responses. Serotonin 27-36 coagulation factor II, thrombin Homo sapiens 89-97