PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10964945-5 2000 Using alpha(1A) subunit chimeras expressing SCA6 mutations, we show that the SCA6 polyglutamine expansion shifts the voltage dependence of channel activation and rate of inactivation only when expressed with beta(4) subunits and impairs normal G-protein regulation of P/Q channels. polyglutamine 82-95 a1-a Xenopus laevis 6-14