PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10960075-0 2000 The p38 MAP kinase inhibitor SB203580 enhances nuclear factor-kappa B transcriptional activity by a non-specific effect upon the ERK pathway. SB 203580 29-37 mitogen-activated protein kinase 3 Homo sapiens 129-132 10960075-6 2000 Overexpression of kinase-deficient mutants belonging to the ERK1/2, JNK, and p38 pathways showed that only dominant-negative Raf-1 abrogated SB203580-enhanced NF-kappaB activity. SB 203580 141-149 mitogen-activated protein kinase 3 Homo sapiens 60-66 10960075-7 2000 This would implicate the involvement of the ERK1/2 pathway in the enhancing effects of SB203580 on NF-kappaB-mediated gene transcription. SB 203580 87-95 mitogen-activated protein kinase 3 Homo sapiens 44-50 10960075-9 2000 SB203580 at higher concentrations activates the ERK pathway, which subsequently enhances NF-kappaB transcriptional activity. SB 203580 0-8 mitogen-activated protein kinase 3 Homo sapiens 48-51