PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10928986-3 2000 We investigated whether platelet-derived products (PDP) released from activated human platelets increase ROS production, resulting in the induction of TF expression in vascular smooth muscle cells (SMC). Reactive Oxygen Species 105-108 coagulation factor III, tissue factor Homo sapiens 151-153 10928986-4 2000 PDP induced a time- and concentration-dependent increase in ROS generation in cultured SMC that was mediated mainly by PDGF-AB and TGF-beta1 and impaired by the flavin inhibitor diphenylene iodonium. Reactive Oxygen Species 60-63 transforming growth factor beta 1 Homo sapiens 131-140 10928986-5 2000 Increased ROS formation was associated with enhanced mRNA levels of the small NAD(P)H oxidase subunit p22phox or its smooth muscle isoform. Reactive Oxygen Species 10-13 cytochrome b-245 alpha chain Homo sapiens 102-109 10928986-6 2000 Transient transfection with a p22phox antisense vector decreased PDP-induced ROS generation. Reactive Oxygen Species 77-80 cytochrome b-245 alpha chain Homo sapiens 30-37