PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10601816-9	2000	Vehicle treated OB rats displayed a significant impairment in LPS-induced IL-1beta (54%) and TNF-alpha (70%) secretion compared to their sham operated controls, an effect that was potentiated following chronic desipramine treatment.	Desipramine	210-221	tumor necrosis factor	Rattus norvegicus	93-102	
10601816-10	2000	Furthermore, sham animals that were chronically treated with desipramine displayed decreases in LPS-provoked IL-1beta (51%) and TNF-alpha (49%) secretion compared to vehicle treated counterparts.	Desipramine	61-72	tumor necrosis factor	Rattus norvegicus	128-137	
10601816-13	2000	Whilst chronic treatment with desipramine normalized the behavioural hyperactivity observed in OB rats, such treatment further impaired LPS-induced IL-1beta and TNF-alpha secretion in bulbectomized rats.	Desipramine	30-41	tumor necrosis factor	Rattus norvegicus	161-170