PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10556945-0	1999	Effects of rupatadine, a new dual antagonist of histamine and platelet-activating factor receptors, on human cardiac kv1.5 channels.	rupatadine	11-21	potassium voltage-gated channel subfamily A member 5	Homo sapiens	117-122	
10556945-2	1999	The effects of rupatadine, a new dual antagonist of both histamine H1 and platelet-activating factor receptors, were studied on human cloned hKv1.5 channels expressed in Ltk- cells using the whole-cell patch-clamp technique.	rupatadine	15-25	potassium voltage-gated channel subfamily A member 5	Homo sapiens	141-147	
10556945-4	1999	Rupatadine produced a use- and concentration-dependent block of hKv1.5 channels (KD=2.4+/-0.7 micronM) and slowed the deactivation of the tail currents, thus inducing the "crossover" phenomenon.	rupatadine	0-10	potassium voltage-gated channel subfamily A member 5	Homo sapiens	64-70	
10556945-8	1999	Moreover, rupatadine also modified the voltage-dependence of hKv1.5 channel activation, which exhibited two components, the midpoint of the steeper component averaging -25.	rupatadine	10-20	potassium voltage-gated channel subfamily A member 5	Homo sapiens	61-67	
10556945-17	1999	All these results suggest that rupatadine blocks hKv1.5 channels binding to an external and to an internal binding site but only at concentrations much higher than therapeutic plasma levels in man.	rupatadine	31-41	potassium voltage-gated channel subfamily A member 5	Homo sapiens	49-55