PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10359012-2	1999	Upon TPA treatment, the activity of ERK1 and ERK2 rapidly increased, with maximal induction between 1 and 3 h, while ERK2 protein levels remained constant.	Tetradecanoylphorbol Acetate	5-8	mitogen-activated protein kinase 3	Homo sapiens	36-40	
10359012-0	1999	Phorbol ester-induced mononuclear cell differentiation is blocked by the mitogen-activated protein kinase kinase (MEK) inhibitor PD98059.	Phorbol Esters	0-13	mitogen-activated protein kinase kinase 7	Homo sapiens	114-117	
10359012-0	1999	Phorbol ester-induced mononuclear cell differentiation is blocked by the mitogen-activated protein kinase kinase (MEK) inhibitor PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	129-136	mitogen-activated protein kinase kinase 7	Homo sapiens	114-117	
10359012-1	1999	The purpose of this study was to evaluate whether the mitogen-activated protein kinase (MAPK) signaling pathway contributes to 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mononuclear differentiation in the human myeloblastic leukemia ML-1 cells.	Tetradecanoylphorbol Acetate	127-163	mitogen-activated protein kinase 3	Homo sapiens	88-92	
10359012-1	1999	The purpose of this study was to evaluate whether the mitogen-activated protein kinase (MAPK) signaling pathway contributes to 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mononuclear differentiation in the human myeloblastic leukemia ML-1 cells.	Tetradecanoylphorbol Acetate	165-168	mitogen-activated protein kinase 3	Homo sapiens	88-92	
10359012-2	1999	Upon TPA treatment, the activity of ERK1 and ERK2 rapidly increased, with maximal induction between 1 and 3 h, while ERK2 protein levels remained constant.	Tetradecanoylphorbol Acetate	5-8	mitogen-activated protein kinase 1	Homo sapiens	45-49	
10359012-2	1999	Upon TPA treatment, the activity of ERK1 and ERK2 rapidly increased, with maximal induction between 1 and 3 h, while ERK2 protein levels remained constant.	Tetradecanoylphorbol Acetate	5-8	mitogen-activated protein kinase 1	Homo sapiens	117-121	
10359012-3	1999	The activity of JNK1 was also significantly induced, with JNK1 protein levels increasing moderately during exposure to TPA.	Tetradecanoylphorbol Acetate	119-122	mitogen-activated protein kinase 8	Homo sapiens	16-20	
10359012-3	1999	The activity of JNK1 was also significantly induced, with JNK1 protein levels increasing moderately during exposure to TPA.	Tetradecanoylphorbol Acetate	119-122	mitogen-activated protein kinase 8	Homo sapiens	58-62	
10359012-4	1999	Treatment of cells with PD98059, a specific inhibitor of mitogen-activated protein kinase kinase (MEK), inhibited TPA-induced ERK2 activity.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	24-31	mitogen-activated protein kinase kinase 7	Homo sapiens	98-101	
10359012-4	1999	Treatment of cells with PD98059, a specific inhibitor of mitogen-activated protein kinase kinase (MEK), inhibited TPA-induced ERK2 activity.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	24-31	mitogen-activated protein kinase 1	Homo sapiens	126-130	
10359012-4	1999	Treatment of cells with PD98059, a specific inhibitor of mitogen-activated protein kinase kinase (MEK), inhibited TPA-induced ERK2 activity.	Tetradecanoylphorbol Acetate	114-117	mitogen-activated protein kinase kinase 7	Homo sapiens	98-101	
10359012-4	1999	Treatment of cells with PD98059, a specific inhibitor of mitogen-activated protein kinase kinase (MEK), inhibited TPA-induced ERK2 activity.	Tetradecanoylphorbol Acetate	114-117	mitogen-activated protein kinase 1	Homo sapiens	126-130	
10359012-5	1999	Furthermore, PD98059 completely blocked the TPA-induced differentiation of ML-1 cells, as assessed by a number of features associated with mononuclear differentiation including changes in morphology, nonspecific esterase activity, phagocytic ability, NADPH oxidase activity, mitochondrial respiration, and c-jun mRNA inducibility.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	13-20	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	306-311	
10359012-5	1999	Furthermore, PD98059 completely blocked the TPA-induced differentiation of ML-1 cells, as assessed by a number of features associated with mononuclear differentiation including changes in morphology, nonspecific esterase activity, phagocytic ability, NADPH oxidase activity, mitochondrial respiration, and c-jun mRNA inducibility.	Tetradecanoylphorbol Acetate	44-47	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	306-311	
10359012-6	1999	We conclude that activation of the MEK/ERK signaling pathway is necessary for TPA-induced mononuclear cell differentiation.	Tetradecanoylphorbol Acetate	78-81	mitogen-activated protein kinase kinase 7	Homo sapiens	35-38	
10359012-6	1999	We conclude that activation of the MEK/ERK signaling pathway is necessary for TPA-induced mononuclear cell differentiation.	Tetradecanoylphorbol Acetate	78-81	mitogen-activated protein kinase 3	Homo sapiens	39-42