PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10208851-0 1999 Expression of extended polyglutamine sequentially activates initiator and effector caspases. polyglutamine 23-36 caspase 8 Homo sapiens 83-91 10208851-7 1999 This is the first direct evidence that the expression of extended polyQ activates caspases and together with the previous findings that some of the products of genes responsible for CAG repeat diseases are substrates of caspase-3 indicates an important role of caspases in the pathogenesis of these diseases. polyglutamine 66-71 caspase 8 Homo sapiens 82-90 10208851-7 1999 This is the first direct evidence that the expression of extended polyQ activates caspases and together with the previous findings that some of the products of genes responsible for CAG repeat diseases are substrates of caspase-3 indicates an important role of caspases in the pathogenesis of these diseases. polyglutamine 66-71 caspase 8 Homo sapiens 261-269