PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10202208-3 1999 After local tissue injury, the release of chemical mediators such as potassium ions, ATP, bradykinin and prostaglandin E2 directly activate nerve endings and indirectly trigger the release of algesic mediators such as histamine, 5-hydroxytryptamine and nerve growth factor from other cells, which, in turn, stimulate proximal afferent nerve endings and silent nociceptors. Serotonin 229-248 kininogen 1 Homo sapiens 90-100