PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10202034-2 1999 Freshly isolated monocytes treated with the protein phosphatase inhibitor okadaic acid secreted high levels of IL-6 protein, which coincided with enhanced binding activity of NF-kappa B as well as with phosphorylation and activation of the ERK1/2 and JNK proteins. Okadaic Acid 74-86 interleukin 6 Homo sapiens 111-115 10202034-2 1999 Freshly isolated monocytes treated with the protein phosphatase inhibitor okadaic acid secreted high levels of IL-6 protein, which coincided with enhanced binding activity of NF-kappa B as well as with phosphorylation and activation of the ERK1/2 and JNK proteins. Okadaic Acid 74-86 nuclear factor kappa B subunit 1 Homo sapiens 175-185 10202034-2 1999 Freshly isolated monocytes treated with the protein phosphatase inhibitor okadaic acid secreted high levels of IL-6 protein, which coincided with enhanced binding activity of NF-kappa B as well as with phosphorylation and activation of the ERK1/2 and JNK proteins. Okadaic Acid 74-86 mitogen-activated protein kinase 3 Homo sapiens 240-246 10202034-2 1999 Freshly isolated monocytes treated with the protein phosphatase inhibitor okadaic acid secreted high levels of IL-6 protein, which coincided with enhanced binding activity of NF-kappa B as well as with phosphorylation and activation of the ERK1/2 and JNK proteins. Okadaic Acid 74-86 mitogen-activated protein kinase 8 Homo sapiens 251-254 10202034-3 1999 The ERK pathway-specific inhibitor PD98059 inhibited IL-6 secretion from monocytes. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 35-42 mitogen-activated protein kinase 1 Homo sapiens 4-7 10202034-3 1999 The ERK pathway-specific inhibitor PD98059 inhibited IL-6 secretion from monocytes. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 35-42 interleukin 6 Homo sapiens 53-57 10202034-5 1999 By using PD98059, we demonstrated that the Raf1/MEK1/ERK1/2 pathway did not affect the DNA binding of NF-kappa B but, rather, acted at the level of transcriptional activity of NF-kappa B. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 9-16 Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens 43-47 10202034-5 1999 By using PD98059, we demonstrated that the Raf1/MEK1/ERK1/2 pathway did not affect the DNA binding of NF-kappa B but, rather, acted at the level of transcriptional activity of NF-kappa B. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 9-16 mitogen-activated protein kinase kinase 1 Homo sapiens 48-52 10202034-5 1999 By using PD98059, we demonstrated that the Raf1/MEK1/ERK1/2 pathway did not affect the DNA binding of NF-kappa B but, rather, acted at the level of transcriptional activity of NF-kappa B. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 9-16 mitogen-activated protein kinase 3 Homo sapiens 53-59 10202034-5 1999 By using PD98059, we demonstrated that the Raf1/MEK1/ERK1/2 pathway did not affect the DNA binding of NF-kappa B but, rather, acted at the level of transcriptional activity of NF-kappa B. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 9-16 nuclear factor kappa B subunit 1 Homo sapiens 176-186 10202034-7 1999 We conclude that okadaic acid-induced IL-6 gene expression is at least partly mediated through the ERK1/2 and JNK pathway-dependent activation of NF-kappa B transcriptional capacity. Okadaic Acid 17-29 interleukin 6 Homo sapiens 38-42 10202034-7 1999 We conclude that okadaic acid-induced IL-6 gene expression is at least partly mediated through the ERK1/2 and JNK pathway-dependent activation of NF-kappa B transcriptional capacity. Okadaic Acid 17-29 mitogen-activated protein kinase 3 Homo sapiens 99-105 10202034-7 1999 We conclude that okadaic acid-induced IL-6 gene expression is at least partly mediated through the ERK1/2 and JNK pathway-dependent activation of NF-kappa B transcriptional capacity. Okadaic Acid 17-29 mitogen-activated protein kinase 8 Homo sapiens 110-113 10202034-7 1999 We conclude that okadaic acid-induced IL-6 gene expression is at least partly mediated through the ERK1/2 and JNK pathway-dependent activation of NF-kappa B transcriptional capacity. Okadaic Acid 17-29 nuclear factor kappa B subunit 1 Homo sapiens 146-156