PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10098743-0 1999 Induction of JNK and c-Abl signalling by cisplatin and oxaliplatin in mismatch repair-proficient and -deficient cells. Cisplatin 41-50 mitogen-activated protein kinase 8 Homo sapiens 13-16 10098743-0 1999 Induction of JNK and c-Abl signalling by cisplatin and oxaliplatin in mismatch repair-proficient and -deficient cells. Cisplatin 41-50 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 21-26 10098743-0 1999 Induction of JNK and c-Abl signalling by cisplatin and oxaliplatin in mismatch repair-proficient and -deficient cells. Oxaliplatin 55-66 mitogen-activated protein kinase 8 Homo sapiens 13-16 10098743-0 1999 Induction of JNK and c-Abl signalling by cisplatin and oxaliplatin in mismatch repair-proficient and -deficient cells. Oxaliplatin 55-66 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 21-26 10098743-3 1999 To identify the signal transduction pathways with which the detector communicates, we investigated the effect of loss of DNA mismatch repair on activation of known damage-responsive pathways, and recently reported that cisplatin differentially activates c-Jun NH2-terminal kinase (JNK) and c-Abl in repair-proficient vs.-deficient cells. Cisplatin 219-228 mitogen-activated protein kinase 8 Homo sapiens 254-279 10098743-3 1999 To identify the signal transduction pathways with which the detector communicates, we investigated the effect of loss of DNA mismatch repair on activation of known damage-responsive pathways, and recently reported that cisplatin differentially activates c-Jun NH2-terminal kinase (JNK) and c-Abl in repair-proficient vs.-deficient cells. Cisplatin 219-228 mitogen-activated protein kinase 8 Homo sapiens 281-284 10098743-3 1999 To identify the signal transduction pathways with which the detector communicates, we investigated the effect of loss of DNA mismatch repair on activation of known damage-responsive pathways, and recently reported that cisplatin differentially activates c-Jun NH2-terminal kinase (JNK) and c-Abl in repair-proficient vs.-deficient cells. Cisplatin 219-228 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 290-295 10098743-5 1999 The results confirm that cisplatin activates JNK kinase 5.7 +/- 1.5 (s.d. Cisplatin 25-34 mitogen-activated protein kinase 8 Homo sapiens 45-48 10098743-6 1999 )-fold more efficiently in DNA mismatch repair-proficient than repair-deficient cells, and that the c-Abl response to cisplatin is completely absent in DNA mismatch repair-deficient cells. Cisplatin 118-127 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 100-105 10098743-9 1999 The DNA mismatch repair system plays an important part in the recognition of cisplatin adducts, and activation of both the JNK and c-Abl kinases in response to cisplatin damage is dependent on the detector function of the DNA mismatch repair proteins. Cisplatin 77-86 mitogen-activated protein kinase 8 Homo sapiens 123-126 10098743-9 1999 The DNA mismatch repair system plays an important part in the recognition of cisplatin adducts, and activation of both the JNK and c-Abl kinases in response to cisplatin damage is dependent on the detector function of the DNA mismatch repair proteins. Cisplatin 77-86 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 131-136 10098743-9 1999 The DNA mismatch repair system plays an important part in the recognition of cisplatin adducts, and activation of both the JNK and c-Abl kinases in response to cisplatin damage is dependent on the detector function of the DNA mismatch repair proteins. Cisplatin 160-169 mitogen-activated protein kinase 8 Homo sapiens 123-126 10098743-9 1999 The DNA mismatch repair system plays an important part in the recognition of cisplatin adducts, and activation of both the JNK and c-Abl kinases in response to cisplatin damage is dependent on the detector function of the DNA mismatch repair proteins. Cisplatin 160-169 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 131-136