PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10051431-4	1999	Activation of JNK in CHO-m3 cells by the agonist methacholine (MCh) was delayed in onset and more sustained relative to that of ERK in either CHO-m2 or CHO-m3 cells.	Methacholine Chloride	49-61	mitogen-activated protein kinase 8	Homo sapiens	14-17	
10051431-4	1999	Activation of JNK in CHO-m3 cells by the agonist methacholine (MCh) was delayed in onset and more sustained relative to that of ERK in either CHO-m2 or CHO-m3 cells.	Methacholine Chloride	63-66	mitogen-activated protein kinase 8	Homo sapiens	14-17	
10051431-5	1999	The EC50 values for MCh-induced ERK activation in both cell types were essentially identical and similar to that for JNK activation in CHO-m3 cells, suggesting little amplification of the response.	Methacholine Chloride	20-23	mitogen-activated protein kinase 1	Homo sapiens	32-35	
10051431-6	1999	Agonist-stimulated Ins(1,4,5)P3 accumulation in CHO-m3 cells was insensitive to pertussis toxin (PTX), consistent with a Gq/phosphoinositide-specific phospholipase C-beta mediated pathway, whereas a significant component of ERK and JNK activation in CHO-m3 cells was PTX-sensitive, indicating Gi/o involvement.	Inositol 1,4,5-Trisphosphate	19-31	mitogen-activated protein kinase 1	Homo sapiens	224-227	
10051431-6	1999	Agonist-stimulated Ins(1,4,5)P3 accumulation in CHO-m3 cells was insensitive to pertussis toxin (PTX), consistent with a Gq/phosphoinositide-specific phospholipase C-beta mediated pathway, whereas a significant component of ERK and JNK activation in CHO-m3 cells was PTX-sensitive, indicating Gi/o involvement.	Inositol 1,4,5-Trisphosphate	19-31	mitogen-activated protein kinase 8	Homo sapiens	232-235