PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10048600-3	1999	In the present study, in vitro metabolism of risperidone (100 microM) was investigated using the recombinant human cytochrome P450 (CYP) enzymes CYP1A1, CYP1A2, CYP2C8, CYP2C9-arg144, CYP2C9-cys144, CYP2C19, CYP2D6, CYP3A4 and CYP3A5 supplemented with an NADPH-generating system.	Risperidone	45-56	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	115-130	
10048600-3	1999	In the present study, in vitro metabolism of risperidone (100 microM) was investigated using the recombinant human cytochrome P450 (CYP) enzymes CYP1A1, CYP1A2, CYP2C8, CYP2C9-arg144, CYP2C9-cys144, CYP2C19, CYP2D6, CYP3A4 and CYP3A5 supplemented with an NADPH-generating system.	Risperidone	45-56	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	132-135	
10048600-3	1999	In the present study, in vitro metabolism of risperidone (100 microM) was investigated using the recombinant human cytochrome P450 (CYP) enzymes CYP1A1, CYP1A2, CYP2C8, CYP2C9-arg144, CYP2C9-cys144, CYP2C19, CYP2D6, CYP3A4 and CYP3A5 supplemented with an NADPH-generating system.	Risperidone	45-56	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	145-151	
10048600-3	1999	In the present study, in vitro metabolism of risperidone (100 microM) was investigated using the recombinant human cytochrome P450 (CYP) enzymes CYP1A1, CYP1A2, CYP2C8, CYP2C9-arg144, CYP2C9-cys144, CYP2C19, CYP2D6, CYP3A4 and CYP3A5 supplemented with an NADPH-generating system.	Risperidone	45-56	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	153-159	
10048600-3	1999	In the present study, in vitro metabolism of risperidone (100 microM) was investigated using the recombinant human cytochrome P450 (CYP) enzymes CYP1A1, CYP1A2, CYP2C8, CYP2C9-arg144, CYP2C9-cys144, CYP2C19, CYP2D6, CYP3A4 and CYP3A5 supplemented with an NADPH-generating system.	Risperidone	45-56	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	161-167	
10048600-3	1999	In the present study, in vitro metabolism of risperidone (100 microM) was investigated using the recombinant human cytochrome P450 (CYP) enzymes CYP1A1, CYP1A2, CYP2C8, CYP2C9-arg144, CYP2C9-cys144, CYP2C19, CYP2D6, CYP3A4 and CYP3A5 supplemented with an NADPH-generating system.	Risperidone	45-56	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	169-175	
10048600-3	1999	In the present study, in vitro metabolism of risperidone (100 microM) was investigated using the recombinant human cytochrome P450 (CYP) enzymes CYP1A1, CYP1A2, CYP2C8, CYP2C9-arg144, CYP2C9-cys144, CYP2C19, CYP2D6, CYP3A4 and CYP3A5 supplemented with an NADPH-generating system.	Risperidone	45-56	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	184-190	
10048600-3	1999	In the present study, in vitro metabolism of risperidone (100 microM) was investigated using the recombinant human cytochrome P450 (CYP) enzymes CYP1A1, CYP1A2, CYP2C8, CYP2C9-arg144, CYP2C9-cys144, CYP2C19, CYP2D6, CYP3A4 and CYP3A5 supplemented with an NADPH-generating system.	Risperidone	45-56	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	199-206	
10048600-3	1999	In the present study, in vitro metabolism of risperidone (100 microM) was investigated using the recombinant human cytochrome P450 (CYP) enzymes CYP1A1, CYP1A2, CYP2C8, CYP2C9-arg144, CYP2C9-cys144, CYP2C19, CYP2D6, CYP3A4 and CYP3A5 supplemented with an NADPH-generating system.	Risperidone	45-56	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	208-214	
10048600-3	1999	In the present study, in vitro metabolism of risperidone (100 microM) was investigated using the recombinant human cytochrome P450 (CYP) enzymes CYP1A1, CYP1A2, CYP2C8, CYP2C9-arg144, CYP2C9-cys144, CYP2C19, CYP2D6, CYP3A4 and CYP3A5 supplemented with an NADPH-generating system.	Risperidone	45-56	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	216-222	
10048600-3	1999	In the present study, in vitro metabolism of risperidone (100 microM) was investigated using the recombinant human cytochrome P450 (CYP) enzymes CYP1A1, CYP1A2, CYP2C8, CYP2C9-arg144, CYP2C9-cys144, CYP2C19, CYP2D6, CYP3A4 and CYP3A5 supplemented with an NADPH-generating system.	Risperidone	45-56	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	227-233	
10048600-3	1999	In the present study, in vitro metabolism of risperidone (100 microM) was investigated using the recombinant human cytochrome P450 (CYP) enzymes CYP1A1, CYP1A2, CYP2C8, CYP2C9-arg144, CYP2C9-cys144, CYP2C19, CYP2D6, CYP3A4 and CYP3A5 supplemented with an NADPH-generating system.	NADP	255-260	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	132-135	
10048600-5	1999	Of these enzymes, CYPs 2D6, 3A4 and 3A5 were found to be the ones capable of metabolising risperidone to 9-hydroxyrisperidone, with activities of 7.5, 0.4 and 0.2 pmol pmol(-1) CYP min(-1), respectively.	Risperidone	90-101	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	18-21	
10048600-5	1999	Of these enzymes, CYPs 2D6, 3A4 and 3A5 were found to be the ones capable of metabolising risperidone to 9-hydroxyrisperidone, with activities of 7.5, 0.4 and 0.2 pmol pmol(-1) CYP min(-1), respectively.	Paliperidone Palmitate	105-125	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	18-21	
10048600-6	1999	A correlation study using a panel of human liver microsomes showed that the formation of 9-hydroxyrisperidone is highly correlated with CYP2D6 and 3A activities.	Paliperidone Palmitate	89-109	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	136-142	
10048600-7	1999	Thus, both CYP2D6 and 3A4 are involved in the 9-hydroxylation of risperidone at the concentration of risperidone used in this study.	Risperidone	65-76	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	11-17	
10048600-7	1999	Thus, both CYP2D6 and 3A4 are involved in the 9-hydroxylation of risperidone at the concentration of risperidone used in this study.	Risperidone	101-112	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	11-17	
10048600-8	1999	This observation is confirmed by the findings that both quinidine (inhibitor of CYP2D6) and ketoconazole (inhibitor of CYP3A4) can inhibit the formation of 9-hydroxyrisperidone.	Quinidine	56-65	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	80-86	
10048600-8	1999	This observation is confirmed by the findings that both quinidine (inhibitor of CYP2D6) and ketoconazole (inhibitor of CYP3A4) can inhibit the formation of 9-hydroxyrisperidone.	Ketoconazole	92-104	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	119-125	
10048600-8	1999	This observation is confirmed by the findings that both quinidine (inhibitor of CYP2D6) and ketoconazole (inhibitor of CYP3A4) can inhibit the formation of 9-hydroxyrisperidone.	Paliperidone Palmitate	156-176	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	80-86	
10048600-8	1999	This observation is confirmed by the findings that both quinidine (inhibitor of CYP2D6) and ketoconazole (inhibitor of CYP3A4) can inhibit the formation of 9-hydroxyrisperidone.	Paliperidone Palmitate	156-176	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	119-125	
10048600-9	1999	Furthermore, inducers of CYP can significantly increase the formation of 9-hydroxyrisperidone in rat.	Paliperidone Palmitate	73-93	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	25-28	
10048600-10	1999	The formation of 9-hydroxyrisperidone is highly correlated with testosterone 6beta-hydroxylase activities, suggesting that inducible CYP3A contributes significantly to the metabolism of risperidone in rat.	Paliperidone Palmitate	17-37	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	64-94	
10048600-10	1999	The formation of 9-hydroxyrisperidone is highly correlated with testosterone 6beta-hydroxylase activities, suggesting that inducible CYP3A contributes significantly to the metabolism of risperidone in rat.	Paliperidone Palmitate	17-37	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	133-138	
10048600-10	1999	The formation of 9-hydroxyrisperidone is highly correlated with testosterone 6beta-hydroxylase activities, suggesting that inducible CYP3A contributes significantly to the metabolism of risperidone in rat.	Risperidone	26-37	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	64-94	
10048600-10	1999	The formation of 9-hydroxyrisperidone is highly correlated with testosterone 6beta-hydroxylase activities, suggesting that inducible CYP3A contributes significantly to the metabolism of risperidone in rat.	Risperidone	26-37	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	133-138