PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10022227-2 1998 The enterotoxic antimetabolite 5-fluorouracil (5-FU) induced acute p53-dependent apoptosis in the crypts of both small intestine and midcolon. Fluorouracil 31-45 transformation related protein 53, pseudogene Mus musculus 67-70 10022227-2 1998 The enterotoxic antimetabolite 5-fluorouracil (5-FU) induced acute p53-dependent apoptosis in the crypts of both small intestine and midcolon. Fluorouracil 47-51 transformation related protein 53, pseudogene Mus musculus 67-70 10022227-6 1998 In p53 null (-/-) mice significant reductions in 5-FU-induced apoptosis and relief from the inhibition of cell cycle progression permitted retention of crypt integrity after 5-FU. Fluorouracil 49-53 transformation related protein 53, pseudogene Mus musculus 3-6 10022227-9 1998 Importantly, the tissue toxicity of 5-fluorouracil was genetically determined at a locus (p53) separate from that directly associated with toxin action. Fluorouracil 36-50 transformation related protein 53, pseudogene Mus musculus 90-93