PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
11593542-3	1999	Those purified H-2 antigens were conjugated with TCS by heterobifunctional reagents SPDP [3-(2-pyridyldithio) propionic acid-hydroxysuccinimide ester] and 2-IT (2-iminothiolane).	methyl 4-mercaptobutyrimidate	155-159	histocompatibility-2, MHC	Mus musculus	15-18
11350598-2	2001	During a study aimed at generating a bispecific molecule between BN antagonist (D-Trp(6),Leu(13)-psi[CH(2)NH]-Phe(14))BN(6-14) (Antag1) and mAb22 (anti-FcgammaRI), we attempted to cross-link the two molecules by introducing a thiol group into Antag1 via 2-iminothiolane (2-IT, Traut"s reagent).	methyl 4-mercaptobutyrimidate	254-269	gastrin releasing peptide	Homo sapiens	65-67
11350598-2	2001	During a study aimed at generating a bispecific molecule between BN antagonist (D-Trp(6),Leu(13)-psi[CH(2)NH]-Phe(14))BN(6-14) (Antag1) and mAb22 (anti-FcgammaRI), we attempted to cross-link the two molecules by introducing a thiol group into Antag1 via 2-iminothiolane (2-IT, Traut"s reagent).	methyl 4-mercaptobutyrimidate	254-269	interferon induced transmembrane protein 1	Homo sapiens	89-95
11350598-2	2001	During a study aimed at generating a bispecific molecule between BN antagonist (D-Trp(6),Leu(13)-psi[CH(2)NH]-Phe(14))BN(6-14) (Antag1) and mAb22 (anti-FcgammaRI), we attempted to cross-link the two molecules by introducing a thiol group into Antag1 via 2-iminothiolane (2-IT, Traut"s reagent).	methyl 4-mercaptobutyrimidate	254-269	gastrin releasing peptide	Homo sapiens	118-120
11350598-2	2001	During a study aimed at generating a bispecific molecule between BN antagonist (D-Trp(6),Leu(13)-psi[CH(2)NH]-Phe(14))BN(6-14) (Antag1) and mAb22 (anti-FcgammaRI), we attempted to cross-link the two molecules by introducing a thiol group into Antag1 via 2-iminothiolane (2-IT, Traut"s reagent).	methyl 4-mercaptobutyrimidate	271-275	gastrin releasing peptide	Homo sapiens	65-67
11350598-2	2001	During a study aimed at generating a bispecific molecule between BN antagonist (D-Trp(6),Leu(13)-psi[CH(2)NH]-Phe(14))BN(6-14) (Antag1) and mAb22 (anti-FcgammaRI), we attempted to cross-link the two molecules by introducing a thiol group into Antag1 via 2-iminothiolane (2-IT, Traut"s reagent).	methyl 4-mercaptobutyrimidate	271-275	interferon induced transmembrane protein 1	Homo sapiens	89-95
11350598-2	2001	During a study aimed at generating a bispecific molecule between BN antagonist (D-Trp(6),Leu(13)-psi[CH(2)NH]-Phe(14))BN(6-14) (Antag1) and mAb22 (anti-FcgammaRI), we attempted to cross-link the two molecules by introducing a thiol group into Antag1 via 2-iminothiolane (2-IT, Traut"s reagent).	methyl 4-mercaptobutyrimidate	271-275	gastrin releasing peptide	Homo sapiens	118-120
11593542-3	1999	Those purified H-2 antigens were conjugated with TCS by heterobifunctional reagents SPDP [3-(2-pyridyldithio) propionic acid-hydroxysuccinimide ester] and 2-IT (2-iminothiolane).	methyl 4-mercaptobutyrimidate	161-176	histocompatibility-2, MHC	Mus musculus	15-18
9893958-2	1999	The amine residue of NH2-C3(BHam)2 was converted to a maleimide group by reaction with N-succinimidyl-6-maleimidohexanoate, and the conjugation product was coupled to thiol groups of a monoclonal antibody against osteogenic sarcoma (OST7, IgG1) pretreated with 2-iminothiolane to prepare C3(BHam)2-OST7.	methyl 4-mercaptobutyrimidate	261-276	complement component 3	Mus musculus	25-34
3782113-2	1986	125I-Labeled HMG 17 was cross-linked to core histones using the protein-protein cross-linking reagent 2-iminothiolane.	methyl 4-mercaptobutyrimidate	102-117	high mobility group nucleosomal binding domain 2	Homo sapiens	13-19
9167276-4	1997	NCS was covalently coupled to transferrin using the heterobifunctional reagent sulfo-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) and 2-iminothiolane to give a stable thioether-linked conjugate with a ratio of 1.6 mol of NCS per mole of transferrin.	methyl 4-mercaptobutyrimidate	143-158	transferrin	Homo sapiens	30-41
8969457-2	1996	The conjugation of transferrin to liposomes was carried out using N-succinimidyl 3-(2-pyridyldithio)-propionate and 2-iminothiolane as activating agents for the liposomes and the protein.	methyl 4-mercaptobutyrimidate	116-131	transferrin	Homo sapiens	19-30
3145738-9	1988	When ETF-Q ox was modified with 2-iminothiolane to introduce 4-mercaptobutyramidine groups, only a minor effect on the activity of the enzyme was observed.	methyl 4-mercaptobutyrimidate	32-47	electron transfer flavoprotein dehydrogenase	Homo sapiens	5-13
9669399-12	1998	For a dose of 14.2 MBq 67Cu-2-iminothiolane-BAT-Lym-1 that induced a platelet nadir of 20% of baseline (Grade II), the model predicted that at least 20 days were needed before a second 14.2-MBq injection if a subsequent nadir of <10% of baseline (Grade IV) was to be avoided.	methyl 4-mercaptobutyrimidate	28-43	Fc receptor, IgG, low affinity IIb	Mus musculus	48-53
2324823-4	1990	It was converted to p-bromoacetamidobenzyl-DOTA (BAD), and conjugated to monoclonal antibody Lym-1 via 2-iminothiolane, either as the free ligand or as the 88Y chelate.	methyl 4-mercaptobutyrimidate	103-118	Fc receptor, IgG, low affinity IIb	Mus musculus	93-98
2783415-1	1989	We have conjugated a murine monoclonal antibody (B4G7) against the human epidermal growth factor (EGF) receptor to gelonin, a 60S ribosome inactivating protein, via N-succinimidyl-3-(2-pyridyldithio)propionate (SPDP) and 2-iminothiolane.	methyl 4-mercaptobutyrimidate	221-236	epidermal growth factor receptor	Homo sapiens	73-111
6252348-7	1980	Upon cross-linking with methyl 4-mercaptobutyrimidate hydrochloride a small amount of what seems to be a heterodimer made up of the N-terminal gag protein p10 and the hydrophobic membrane glycoprotein gp36 can be observed.	methyl 4-mercaptobutyrimidate	24-67	melanoma antigen	Mus musculus	143-146
3956508-0	1986	Cross-linking of elongation factor 2 to rat-liver ribosomal proteins by 2-iminothiolane.	methyl 4-mercaptobutyrimidate	72-87	eukaryotic translation elongation factor 2	Rattus norvegicus	17-36
6252348-7	1980	Upon cross-linking with methyl 4-mercaptobutyrimidate hydrochloride a small amount of what seems to be a heterodimer made up of the N-terminal gag protein p10 and the hydrophobic membrane glycoprotein gp36 can be observed.	methyl 4-mercaptobutyrimidate	24-67	S100 calcium binding protein A10 (calpactin)	Mus musculus	155-158
21169024-5	2011	Monoclonal immunoglobulin with binding-avidity specifically for HER2/neu was thiolated with 2-iminothiolane at the terminal epsilon-amine group of lysine amino acid residues.	methyl 4-mercaptobutyrimidate	92-107	erb-b2 receptor tyrosine kinase 2	Homo sapiens	64-72
27591569-3	2016	Pyridyl disulfide functionalized porcine pancreatic lipase (PPL-S-S-Py) was prepared by treatment of PPL with Traut"s reagent (2-iminothiolane) and 2,2"-dithiodipyridine.	methyl 4-mercaptobutyrimidate	127-142	pancreatic lipase	Homo sapiens	41-58
27591569-3	2016	Pyridyl disulfide functionalized porcine pancreatic lipase (PPL-S-S-Py) was prepared by treatment of PPL with Traut"s reagent (2-iminothiolane) and 2,2"-dithiodipyridine.	methyl 4-mercaptobutyrimidate	127-142	periplakin	Homo sapiens	60-63
23720860-15	2004	(15) radiolabeled IL-18bp-Fc-IL-1ra with (99m)Tc via 2-iminothiolane reduction to produce (99m)Tc-IL-18bp-Fc-IL-1ra for use with single-photon emission computed tomography (SPECT) imaging of inflammation in mice.	methyl 4-mercaptobutyrimidate	53-68	interleukin 18 binding protein	Mus musculus	18-25
23720860-15	2004	(15) radiolabeled IL-18bp-Fc-IL-1ra with (99m)Tc via 2-iminothiolane reduction to produce (99m)Tc-IL-18bp-Fc-IL-1ra for use with single-photon emission computed tomography (SPECT) imaging of inflammation in mice.	methyl 4-mercaptobutyrimidate	53-68	interleukin 1 receptor type 1	Homo sapiens	29-35
23720860-15	2004	(15) radiolabeled IL-18bp-Fc-IL-1ra with (99m)Tc via 2-iminothiolane reduction to produce (99m)Tc-IL-18bp-Fc-IL-1ra for use with single-photon emission computed tomography (SPECT) imaging of inflammation in mice.	methyl 4-mercaptobutyrimidate	53-68	interleukin 18 binding protein	Mus musculus	98-105
23720860-15	2004	(15) radiolabeled IL-18bp-Fc-IL-1ra with (99m)Tc via 2-iminothiolane reduction to produce (99m)Tc-IL-18bp-Fc-IL-1ra for use with single-photon emission computed tomography (SPECT) imaging of inflammation in mice.	methyl 4-mercaptobutyrimidate	53-68	interleukin 1 receptor type 1	Homo sapiens	109-115
23720862-17	2004	(14) radiolabeled TNFR2-Fc-IL-1ra with (99m)Tc via 2-iminothiolane reduction to produce (99m)Tc-TNFR2-Fc-IL-1ra for use with single-photon emission computed tomography (SPECT) imaging of inflammation in mice.	methyl 4-mercaptobutyrimidate	51-66	tumor necrosis factor receptor superfamily, member 1b	Mus musculus	18-23
23720862-17	2004	(14) radiolabeled TNFR2-Fc-IL-1ra with (99m)Tc via 2-iminothiolane reduction to produce (99m)Tc-TNFR2-Fc-IL-1ra for use with single-photon emission computed tomography (SPECT) imaging of inflammation in mice.	methyl 4-mercaptobutyrimidate	51-66	interleukin 1 receptor antagonist	Mus musculus	27-33
23720862-17	2004	(14) radiolabeled TNFR2-Fc-IL-1ra with (99m)Tc via 2-iminothiolane reduction to produce (99m)Tc-TNFR2-Fc-IL-1ra for use with single-photon emission computed tomography (SPECT) imaging of inflammation in mice.	methyl 4-mercaptobutyrimidate	51-66	tumor necrosis factor receptor superfamily, member 1b	Mus musculus	96-101
23720862-17	2004	(14) radiolabeled TNFR2-Fc-IL-1ra with (99m)Tc via 2-iminothiolane reduction to produce (99m)Tc-TNFR2-Fc-IL-1ra for use with single-photon emission computed tomography (SPECT) imaging of inflammation in mice.	methyl 4-mercaptobutyrimidate	51-66	interleukin 1 receptor antagonist	Mus musculus	105-111
24324676-4	2013	The amino group of C3(BHam)2 was converted to a maleimide group, and was coupled to thiol groups of annexin A5 pretreated with 2-iminothiolane.	methyl 4-mercaptobutyrimidate	127-142	complement component 3	Mus musculus	19-28
24324676-4	2013	The amino group of C3(BHam)2 was converted to a maleimide group, and was coupled to thiol groups of annexin A5 pretreated with 2-iminothiolane.	methyl 4-mercaptobutyrimidate	127-142	annexin A5	Mus musculus	100-110
21843776-4	2011	METHODS: The (99m)Tc-IL-18bp-Fc-IL-1ra was obtained by direct labeling via 2-iminothiolane reduction.	methyl 4-mercaptobutyrimidate	75-90	interleukin 18 binding protein	Rattus norvegicus	21-28
21843776-4	2011	METHODS: The (99m)Tc-IL-18bp-Fc-IL-1ra was obtained by direct labeling via 2-iminothiolane reduction.	methyl 4-mercaptobutyrimidate	75-90	interleukin 1 receptor antagonist	Rattus norvegicus	32-38
20000719-6	2010	The 2-iminothiolane modified N,O-SOCC and CS complex could be used for preparing nanoparticles by a polyelectrolyte self-assembly method, and the release of bFGF from the nanoparticles was successfully controlled.	methyl 4-mercaptobutyrimidate	4-19	fibroblast growth factor 2	Homo sapiens	157-161
12542528-5	2003	Flow cytometric quantification of tyrosine phosphorylation in CD14+ monocytes showed that 5-chloro-2-methylisothiazolinone plus 2-methylisothiazolinone, 2, 4, 6-trinitrochlorobenzene, N-hydroxymaleimide, and N-ethylmaleimide but not sulfosuccinimidyl acetate and 2-iminothiolane strongly induced this process.	methyl 4-mercaptobutyrimidate	263-278	CD14 molecule	Homo sapiens	62-66
17445418-2	2007	METHODS: Recombinant C2A domain of synaptotagmin I, overexpressed in E. Coli, was thiolated with 2-iminothiolane (2-IT) and labeled with (99)Tc(m).	methyl 4-mercaptobutyrimidate	97-112	synaptotagmin-2	Oryctolagus cuniculus	35-50
17445418-2	2007	METHODS: Recombinant C2A domain of synaptotagmin I, overexpressed in E. Coli, was thiolated with 2-iminothiolane (2-IT) and labeled with (99)Tc(m).	methyl 4-mercaptobutyrimidate	114-118	synaptotagmin-2	Oryctolagus cuniculus	35-50