PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25619394-8	2015	Addition of the p53 inhibitor cyclic PFT-alpha (5, 25 mumol/L) in HepG2 cells dose-dependently enhanced the metabolism of DEM and TEST, whereas addition of the p53 activator NSC 66811 (3, 10, 25 mumol/L) dose-dependently inhibited the metabolism.	QB 102	30-46	tumor protein p53	Homo sapiens	16-19
31894477-9	2020	An investigation of the function of CSC-like cells revealed that knockdown of PTK7 reduced their sphere formation, promoted apoptosis, and suppressed their migration and invasion abilities, all of which could be significantly reversed by PFTalpha.	QB 102	238-246	protein tyrosine kinase 7 (inactive)	Homo sapiens	78-82
31894477-10	2020	Mechanistic studies showed that PFTalpha could attenuate the upregulation of P53, MKK3, and cleaved caspase 3 expression that was induced by PTK7 knockdown in CSC-like cells.	QB 102	32-40	tumor protein p53	Homo sapiens	77-80
31894477-10	2020	Mechanistic studies showed that PFTalpha could attenuate the upregulation of P53, MKK3, and cleaved caspase 3 expression that was induced by PTK7 knockdown in CSC-like cells.	QB 102	32-40	mitogen-activated protein kinase kinase 3	Homo sapiens	82-86
31894477-10	2020	Mechanistic studies showed that PFTalpha could attenuate the upregulation of P53, MKK3, and cleaved caspase 3 expression that was induced by PTK7 knockdown in CSC-like cells.	QB 102	32-40	protein tyrosine kinase 7 (inactive)	Homo sapiens	141-145
31809756-11	2020	When Akt and p53 were suppressed by LY294002 and PFTalpha, respectively, sesamin exerted no additional effects.	QB 102	49-57	AKT serine/threonine kinase 1	Homo sapiens	5-8
27132887-4	2016	We report here that a compound cocktail containing cyclic pifithrin-a (a P53 inhibitor), A-83-01, CHIR99021, thiazovivin, NaB, and PD0325901 significantly improves the reprogramming efficiency (170-fold more) for hUCs.	QB 102	51-69	tumor protein p53	Homo sapiens	73-76