PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25347332-6	2015	Only AAD cells responded to 21OH with an elevated IL2 and IL2RA mRNA synthesis (p = 0.004 and p = 0.009 versus controls, respectively), paralleled by increased supernatant levels of both cytokines (p = 0.031 and p = 0.001 versus controls).	21oh	28-32	interleukin 2	Homo sapiens	50-53
28165447-7	2017	Intravenous injection of the therapeutic CYP21 vector allowed 21OH expression in adrenal tissue, resulting in increased body weight and near normalization of urinary progesterone for more than 15 weeks, improved response to stress and restoration of near-normal expression of (several important genes) in the adrenal cortex.	21oh	62-66	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	41-46
25347332-6	2015	Only AAD cells responded to 21OH with an elevated IL2 and IL2RA mRNA synthesis (p = 0.004 and p = 0.009 versus controls, respectively), paralleled by increased supernatant levels of both cytokines (p = 0.031 and p = 0.001 versus controls).	21oh	28-32	interleukin 2 receptor subunit alpha	Homo sapiens	58-63
25347332-7	2015	IL2 mRNA level in 21OH-stimulated AAD PBMCs correlated negatively with age (p = 0.036) and positively with serum antibodies to 21OH (p = 0.006).	21oh	18-22	interleukin 2	Homo sapiens	0-3
25347332-7	2015	IL2 mRNA level in 21OH-stimulated AAD PBMCs correlated negatively with age (p = 0.036) and positively with serum antibodies to 21OH (p = 0.006).	21oh	127-131	interleukin 2	Homo sapiens	0-3
25347332-8	2015	Carriers of the rs2104286 AA genotype demonstrated higher IL2RA mRNA (p = 0.022) and soluble IL2Ra secretion (p = 0.029) upon 21OH stimulation.	21oh	126-130	interleukin 2 receptor subunit alpha	Homo sapiens	58-63
25347332-8	2015	Carriers of the rs2104286 AA genotype demonstrated higher IL2RA mRNA (p = 0.022) and soluble IL2Ra secretion (p = 0.029) upon 21OH stimulation.	21oh	126-130	interleukin 2 receptor subunit alpha	Homo sapiens	93-98
25347332-11	2015	It confirms specific 21OH-directed reactivity of the peripheral AAD lymphocytes, which display increased synthesis of interleukin-2 and sIL2Ra.	21oh	21-25	interleukin 2	Homo sapiens	118-131
19890026-12	2009	CONCLUSION: Patients with autoimmune Addison"s disease have circulating 21OH-specific T cells, with amino acids 342-361 of 21OH possibly constituting a disease-specific epitope presented by HLA-DRB1*0404.	21oh	72-76	major histocompatibility complex, class II, DR beta 1	Homo sapiens	190-198
24735610-4	2014	Recently, our group has shown that the rigid steroid 21-hydroxy-6,19-epoxyprogesterone (21OH-6,19OP) is a selective GR ligand that behaves as an agonist in transrepression assays and as an antagonist in transactivation ones.	21oh	88-92	nuclear receptor subfamily 3, group C, member 1	Mus musculus	116-118
22723331-6	2012	RESULTS: Major genetic risk for 21OH-AA is in the MHC haplotypes DRB1*04-DQB1*0302 (primarily DRB1*0404) and DRB1*0301-DQB1*0201.	21oh	32-36	major histocompatibility complex, class II, DR beta 1	Homo sapiens	65-69
22723331-6	2012	RESULTS: Major genetic risk for 21OH-AA is in the MHC haplotypes DRB1*04-DQB1*0302 (primarily DRB1*0404) and DRB1*0301-DQB1*0201.	21oh	32-36	major histocompatibility complex, class II, DR beta 1	Homo sapiens	94-98
22723331-6	2012	RESULTS: Major genetic risk for 21OH-AA is in the MHC haplotypes DRB1*04-DQB1*0302 (primarily DRB1*0404) and DRB1*0301-DQB1*0201.	21oh	32-36	major histocompatibility complex, class II, DR beta 1	Homo sapiens	94-98
19890026-6	2009	RESULTS: Cellular proliferation (P = 0.0009) and secretion of interferon-gamma (P < 0.0001) in response to 21OH was significantly higher in patients compared to healthy controls and associated with the presence of 21OH autoantibodies (P = 0.0052).	21oh	110-114	interferon gamma	Homo sapiens	62-78
19890026-12	2009	CONCLUSION: Patients with autoimmune Addison"s disease have circulating 21OH-specific T cells, with amino acids 342-361 of 21OH possibly constituting a disease-specific epitope presented by HLA-DRB1*0404.	21oh	123-127	major histocompatibility complex, class II, DR beta 1	Homo sapiens	190-198
19890026-6	2009	RESULTS: Cellular proliferation (P = 0.0009) and secretion of interferon-gamma (P < 0.0001) in response to 21OH was significantly higher in patients compared to healthy controls and associated with the presence of 21OH autoantibodies (P = 0.0052).	21oh	217-221	interferon gamma	Homo sapiens	62-78
19890026-7	2009	Furthermore, the 21OH-specific production of interferon-gamma was enhanced in the presence of 21OH autoantibodies.	21oh	17-21	interferon gamma	Homo sapiens	45-61
19347184-2	2009	The aim of this study was to determine, by allele-specific PCR, the frequency of microconversions of the CYP21A2, in sixteen patients with the classical forms and in 5 patients with the nonclassical (NC) form of CAH-21OH and correlate genotype with phenotype.	21oh	216-220	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	105-112
19890026-7	2009	Furthermore, the 21OH-specific production of interferon-gamma was enhanced in the presence of 21OH autoantibodies.	21oh	94-98	interferon gamma	Homo sapiens	45-61
19890026-10	2009	An association between cellular immunity to 21OH and the high-risk HLA genotype for Addison"s disease, DRB1*0301-DQ2/DRB1*0404-DQ8, was observed (P = 0.0089).	21oh	44-48	major histocompatibility complex, class II, DR beta 1	Homo sapiens	67-70
19890026-10	2009	An association between cellular immunity to 21OH and the high-risk HLA genotype for Addison"s disease, DRB1*0301-DQ2/DRB1*0404-DQ8, was observed (P = 0.0089).	21oh	44-48	major histocompatibility complex, class II, DR beta 1	Homo sapiens	103-107
19890026-10	2009	An association between cellular immunity to 21OH and the high-risk HLA genotype for Addison"s disease, DRB1*0301-DQ2/DRB1*0404-DQ8, was observed (P = 0.0089).	21oh	44-48	major histocompatibility complex, class II, DR beta 1	Homo sapiens	117-121
19890026-11	2009	Finally, a significant association between the DRB1*0404-DQ8 haplotype and cellular responses to a 21OH-derived peptide predicted to bind to DRB1*0404 was detected (P = 0.0055).	21oh	99-103	major histocompatibility complex, class II, DR beta 1	Homo sapiens	47-51
19890026-11	2009	Finally, a significant association between the DRB1*0404-DQ8 haplotype and cellular responses to a 21OH-derived peptide predicted to bind to DRB1*0404 was detected (P = 0.0055).	21oh	99-103	major histocompatibility complex, class II, DR beta 1	Homo sapiens	141-145
10602386-3	1999	Intra-adrenal injection of hAdCYP21 in 21OH- mice induced hCYP21 mRNA with the highest expression from 2 to 7 days before a gradual decline.	21oh	39-43	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	58-64
18284186-3	2008	Results suggest that the time fluctuation and average position adopted by the H1-H3 loop affect the ability of GR LBD-21OH-6,19OP complex to homodimerize, a necessary step in transcriptome assembly.	21oh	118-122	nuclear receptor subfamily 3 group C member 1	Homo sapiens	111-113
18284186-4	2008	A nuclear localization and a transactivation experiment showed that, although 21OH-6,19OP activates the translocation of the GR, the nuclear complex is unable to induce the transcription of a reporter driven by a promoter, that requires binding to a GR homodimer to be activated.	21oh	78-82	nuclear receptor subfamily 3 group C member 1	Homo sapiens	125-127
14502362-2	2003	We determined by allele-specific PCR the frequency of microconversion in the CYP21A2 gene in 50 Brazilian patients with the classical (salt wasting: SW and simple virilizing: SV) forms and nonclassical (NC) form of CAH-21OH and correlated genotype with phenotype.	21oh	219-223	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	77-84
11171829-8	2001	During or after IFN-alpha therapy, 3/62 initially negative patients (4.8%) developed 21OH-Abs.	21oh	85-89	interferon alpha 1	Homo sapiens	16-25
11171829-12	2001	CONCLUSIONS: IFN-alpha induces 21OH-Abs in some cases, while islet and thyroid specific autoantibodies are more frequently found.	21oh	31-35	interferon alpha 1	Homo sapiens	13-22
10602386-8	1999	This is the first demonstration that a single intra-adrenal injection of an adenoviral vector encoding CYP21 can compensate for the biochemical, endocrine and histological alterations in 21OH-deficient mice, and shows that gene therapy could be a feasible option for treatment of CAH.	21oh	187-191	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	103-108
9550333-1	1998	We have defined extended HLA haplotypes including the HLA class II genes, the non-HLA genes such as TAP1, TAP2 and LMP2, and the (CTG)n microsatellite repeats within the NOTCH4 gene between DRA and 21OH in 33 Japanese HLA homozygous typing cells (HTC).	21oh	198-202	notch receptor 4	Homo sapiens	170-176
9132494-2	1997	Although several CAH causing mutations have been identified in the CYP21 gene of patients with 21OH deficiency, genotyping of the 21OH locus is quite complex because of the high frequency of gene conversion and the presence of multiple mutations on single CAH alleles.	21oh	95-99	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	67-72
7860358-3	1994	The genes encoding the 21OH enzyme are located in the class III segment of the MHC complex.	21oh	23-27	major histocompatibility complex, class I, C	Homo sapiens	79-82
7860358-6	1994	Also, we tested whether presence of autoantibodies against 21OH is associated with specific alleles in MHC.	21oh	59-63	major histocompatibility complex, class I, C	Homo sapiens	103-106
7860358-10	1994	The presence of autoantibodies against 21OH was not found to be directly determined by the MHC alleles; rather it was associated with the clinical form of the disease.	21oh	39-43	major histocompatibility complex, class I, C	Homo sapiens	91-94
34762785-3	2021	A 20-year-old woman, known to have 21OH-CCAH, presented with severe abdominal pain, vomiting, diarrhea, and fever.	21oh	35-39	immunoglobulin kappa variable 1-27	Homo sapiens	0-4
34721410-5	2021	Interferon-gamma (IFNgamma) Elispot and biochemical assays were used to functionally investigate the 21OH-specific T cells, and to map the exactly defined epitopes of 21OH.	21oh	167-171	interferon gamma	Homo sapiens	0-16
34721410-11	2021	Conclusion: We have identified two dominant 21OH epitopes targeted by CD8+ T cells in AAD, restricted by HLA-A2 and HLA-C7, respectively.	21oh	44-48	CD8a molecule	Homo sapiens	70-73