PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31088572-0	2019	Development and application of a tri-allelic PCR assay for screening Vgsc-L1014F kdr mutations associated with pyrethroid and organochlorine resistance in the mosquito Culex quinquefasciatus.	Hydrocarbons, Chlorinated	126-140	CpipJ_CPIJ004993	Culex quinquefasciatus	69-73
29554563-1	2018	The use of DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl) ethane) in some countries, although regulated, is contributing to an increased worldwide risk of exposure to this organochlorine pesticide or its derivative p,p"-DDE [1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene].	Hydrocarbons, Chlorinated	170-184	D-dopachrome tautomerase	Mus musculus	11-14
30384230-5	2019	The concentrations of discriminatory, legacy organochlorine pesticides along with one tetrachlorobiphenyl were greater in the WHB and were directly correlated with the VIP-identified ACs and PCs.	Hydrocarbons, Chlorinated	45-59	VIP peptides	Ursus maritimus	168-171
30519792-0	2018	Organochlorine pesticides exposure in female adolescents: potential impact on sexual hormones and interleukin-1 levels.	Hydrocarbons, Chlorinated	0-14	interleukin 1 alpha	Homo sapiens	98-111
30519792-1	2018	The objective of this study was to assess the potential impact of organochlorine pesticides (OCPs) on IL-1 axis in exposed female adolescents through an observational cross-sectional study.	Hydrocarbons, Chlorinated	66-80	interleukin 1 alpha	Homo sapiens	102-106
29886753-6	2018	Expert opinion: Some pesticides belonging to several chemical classes, such as organochlorine, pyrethroid, and organophosphorus pesticides, have been demonstrated to interact with various uptake and efflux drug transporters, including the efflux pump P-glycoprotein (P-gp) and the uptake organic cation transporters (OCTs).	Hydrocarbons, Chlorinated	79-93	ATP binding cassette subfamily B member 1	Homo sapiens	251-265
29886753-6	2018	Expert opinion: Some pesticides belonging to several chemical classes, such as organochlorine, pyrethroid, and organophosphorus pesticides, have been demonstrated to interact with various uptake and efflux drug transporters, including the efflux pump P-glycoprotein (P-gp) and the uptake organic cation transporters (OCTs).	Hydrocarbons, Chlorinated	79-93	ATP binding cassette subfamily B member 1	Homo sapiens	267-271
29923341-7	2018	In invasive cancer patients, organochlorine levels differed significantly based on clinical characteristics of the primary carcinoma, including stage, grade, ER status, and HER2 status, indicating that body burden of organochlorines may influence the development of specific subtypes of breast cancer.	Hydrocarbons, Chlorinated	29-43	erb-b2 receptor tyrosine kinase 2	Homo sapiens	173-177
29923341-7	2018	In invasive cancer patients, organochlorine levels differed significantly based on clinical characteristics of the primary carcinoma, including stage, grade, ER status, and HER2 status, indicating that body burden of organochlorines may influence the development of specific subtypes of breast cancer.	Hydrocarbons, Chlorinated	217-232	erb-b2 receptor tyrosine kinase 2	Homo sapiens	173-177
29735922-0	2018	Association between Organochlorine Pesticide Levels in Breast Milk and Their Effects on Female Reproduction in a Taiwanese Population.	Hydrocarbons, Chlorinated	20-34	Weaning weight-maternal milk	Bos taurus	62-66
29735922-1	2018	Only few studies have focused on organochlorine pesticides (OCPs) in breast milk and the related health risks for women in Taiwan.	Hydrocarbons, Chlorinated	33-47	Weaning weight-maternal milk	Bos taurus	76-80
29250973-3	2018	METHODS: In an attempt to identify biomarkers monitoring low-dose exposure and hazard, we explored whether organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) may influence the methylation of tumour suppressor gene E-cadherin (CDH1) using peripheral blood cells from 364 healthy Korean subjects.	Hydrocarbons, Chlorinated	107-121	cadherin 1	Homo sapiens	233-243
29250973-3	2018	METHODS: In an attempt to identify biomarkers monitoring low-dose exposure and hazard, we explored whether organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) may influence the methylation of tumour suppressor gene E-cadherin (CDH1) using peripheral blood cells from 364 healthy Korean subjects.	Hydrocarbons, Chlorinated	107-121	cadherin 1	Homo sapiens	245-249
28238206-10	2017	These results indicate that these organochlorines act synergistically with LPS to induce TNF-alpha secretion in PBMC.	Hydrocarbons, Chlorinated	34-49	tumor necrosis factor	Homo sapiens	89-98
28927721-4	2018	Eighty-four percent of CAR-activating compounds were aromatic compounds, and >65% of these active compounds were aromatic hydrocarbons, bisphenols, monoalkyl phenols, phthalates, styrene dimers, diphenyl ethers, organochlorines, and organophosphates.	Hydrocarbons, Chlorinated	215-230	nuclear receptor subfamily 1 group I member 3	Homo sapiens	23-26
28725028-3	2017	We show that field-collected Ugandan Culex quinquefasciatus display CNV for the voltage-gated sodium channel gene (Vgsc), target-site of pyrethroid and organochlorine insecticides.	Hydrocarbons, Chlorinated	152-166	CpipJ_CPIJ004993	Culex quinquefasciatus	80-108
29978130-9	2018	Conclusion: The correlation between the content of selected organochlorine compounds and the composition of fatty acids in cow and mare milk fat indicates the strong influence of these environmental pollutants on the nutritional value of milk fat.	Hydrocarbons, Chlorinated	60-74	Weaning weight-maternal milk	Bos taurus	136-140
29978130-9	2018	Conclusion: The correlation between the content of selected organochlorine compounds and the composition of fatty acids in cow and mare milk fat indicates the strong influence of these environmental pollutants on the nutritional value of milk fat.	Hydrocarbons, Chlorinated	60-74	Weaning weight-maternal milk	Bos taurus	238-242
29243208-0	2018	Plasma Cholinesterase Activity in Female Green Turtles Chelonia mydas Nesting in Laguna de Terminos, Mexico Related to Organochlorine Pesticides in Their Eggs.	Hydrocarbons, Chlorinated	119-133	cholinesterase	Chelonia mydas	7-21
28959657-0	2017	CYP polymorphisms and pathological conditions related to chronic exposure to organochlorine pesticides.	Hydrocarbons, Chlorinated	77-91	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3
28959657-1	2017	The association between genetic variations in the cytochrome P450 (CYP) family genes and pathological conditions related to long-term exposure to organochlorine compounds (OCs) deserves further elucidation.	Hydrocarbons, Chlorinated	146-170	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	50-65
28959657-1	2017	The association between genetic variations in the cytochrome P450 (CYP) family genes and pathological conditions related to long-term exposure to organochlorine compounds (OCs) deserves further elucidation.	Hydrocarbons, Chlorinated	146-170	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	67-70
27748297-0	2016	Association of organochlorine pesticides with the mRNA expression of tumour necrosis factor-alpha (TNF-alpha) & cyclooxygenase-2 (COX-2) genes in idiopathic preterm birth.	Hydrocarbons, Chlorinated	15-29	tumor necrosis factor	Homo sapiens	99-108
27748297-0	2016	Association of organochlorine pesticides with the mRNA expression of tumour necrosis factor-alpha (TNF-alpha) & cyclooxygenase-2 (COX-2) genes in idiopathic preterm birth.	Hydrocarbons, Chlorinated	15-29	prostaglandin-endoperoxide synthase 2	Homo sapiens	116-132
27748297-0	2016	Association of organochlorine pesticides with the mRNA expression of tumour necrosis factor-alpha (TNF-alpha) & cyclooxygenase-2 (COX-2) genes in idiopathic preterm birth.	Hydrocarbons, Chlorinated	15-29	prostaglandin-endoperoxide synthase 2	Homo sapiens	134-139
27748297-3	2016	The present study was planned to investigate the association of organochlorine pesticides (OCPs) with mRNA expression of inflammatory pathway genes such as tumour necrosis factor-alpha (TNF-alpha) and cyclooxygenase-2 (COX-2) in preterm delivery (PTD) cases.	Hydrocarbons, Chlorinated	64-78	tumor necrosis factor	Homo sapiens	186-195
27748297-3	2016	The present study was planned to investigate the association of organochlorine pesticides (OCPs) with mRNA expression of inflammatory pathway genes such as tumour necrosis factor-alpha (TNF-alpha) and cyclooxygenase-2 (COX-2) in preterm delivery (PTD) cases.	Hydrocarbons, Chlorinated	64-78	prostaglandin-endoperoxide synthase 2	Homo sapiens	201-217
27748297-3	2016	The present study was planned to investigate the association of organochlorine pesticides (OCPs) with mRNA expression of inflammatory pathway genes such as tumour necrosis factor-alpha (TNF-alpha) and cyclooxygenase-2 (COX-2) in preterm delivery (PTD) cases.	Hydrocarbons, Chlorinated	64-78	prostaglandin-endoperoxide synthase 2	Homo sapiens	219-224
26647222-6	2016	In H4IIEcells, four organochlorine insecticides, bifenthrin, and 3-PBA decreased cortisol-induced PEPCK gene expression, while o,p"-DDT and methoxychlor inhibited cortisol-stimulated Arg and TAT gene expression.	Hydrocarbons, Chlorinated	20-34	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	98-103
26115335-5	2016	Secondary metabolites of diethylhexyl and diisononyl phthalates (DEHP, DiNP), eight perfluoroalkyl acids, and organochlorines (PCB-153 and p,p -DDE) were quantifiable in 72-100% of maternal serum samples.	Hydrocarbons, Chlorinated	110-125	pyruvate carboxylase	Homo sapiens	127-130
27152359-4	2016	We identified specific congeners of organochlorine pesticides, polychlorinated biphenyls, and polybrominated diphenyl ethers that inhibit mouse and human P-gp, and determined their environmental levels in yellowfin tuna from the Gulf of Mexico.	Hydrocarbons, Chlorinated	36-50	ATP binding cassette subfamily B member 1	Homo sapiens	154-158
26802539-1	2016	Luminescence quenching of the Eu(III)- and Tb(III)-bis (coumarin-3-carboxylic acid) (Ln(III)-(CCA)2) probes has been studied in the presence of organophosphorus or organochlorine pesticides; Phosdrin (P1), Malathion (P2), Profenofos (P3), Formothion (P4), Heptachlor (P5), and Endosulfan (P6).	Hydrocarbons, Chlorinated	164-178	crystallin beta B2	Homo sapiens	85-99
26825782-0	2016	Residues and Distribution of Organochlorine Pesticides in Water and Suspended Particulate Matter from Hangzhou Bay, East China Sea.	Hydrocarbons, Chlorinated	29-43	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	127-130
26232659-0	2015	Prenatal exposure to persistent organochlorine pollutants is associated with high insulin levels in 5-year-old girls.	Hydrocarbons, Chlorinated	32-46	insulin	Homo sapiens	82-89
26451881-11	2015	ZIP Code-level organochlorines were significantly associated with an increased risk of HCC among males (adjusted OR 2.76, 95% CI 1.58, 4.82; p=0.0004), but not associated with HCC among females (adjusted OR 0.83, 95% CI 0.35, 1.93; p=0.6600) (interaction p=0.0075).	Hydrocarbons, Chlorinated	15-30	death associated protein kinase 3	Homo sapiens	0-3
26457621-3	2015	METHODS: In a population-based case control study, we genotyped ABCB1 gene variants at rs1045642 (c.3435C/T) and rs2032582 (c.2677G/T/A) and assessed occupational exposures to organochlorine (OC) and organophosphorus (OP) pesticides based on self-reported occupational use and record-based ambient workplace exposures for 282 PD cases and 514 controls of European ancestry.	Hydrocarbons, Chlorinated	176-190	ATP binding cassette subfamily B member 1	Homo sapiens	64-69
26457621-3	2015	METHODS: In a population-based case control study, we genotyped ABCB1 gene variants at rs1045642 (c.3435C/T) and rs2032582 (c.2677G/T/A) and assessed occupational exposures to organochlorine (OC) and organophosphorus (OP) pesticides based on self-reported occupational use and record-based ambient workplace exposures for 282 PD cases and 514 controls of European ancestry.	Hydrocarbons, Chlorinated	192-194	ATP binding cassette subfamily B member 1	Homo sapiens	64-69
26451881-10	2015	RESULTS: Among California residents of agriculturally intensive areas, previous annual ZIP Code-level exposure to over 14.53 kg/km(2) of organochlorine pesticides (75(th) percentile among controls) was associated with an increased risk of HCC after adjusting for liver disease and diabetes (adjusted odds ratio [OR] 1.87, 95% confidence interval [CI] 1.17, 2.99; p=0.0085).	Hydrocarbons, Chlorinated	137-151	death associated protein kinase 3	Homo sapiens	87-90
25753462-11	2015	In Greenlandic children, a negative association of PC4 (organochlorines) with ever eczema (OR 0.78, 0.61-0.99) was found.	Hydrocarbons, Chlorinated	56-71	proprotein convertase subtilisin/kexin type 4	Homo sapiens	51-54
26333997-3	2015	Here we demonstrate that a pharmaceutical oestrogen and a persistent organochlorine pesticide, both exhibiting low efficacy when studied separately, cooperatively bind to the pregnane X receptor, leading to synergistic activation.	Hydrocarbons, Chlorinated	69-83	nuclear receptor subfamily 1 group I member 2	Homo sapiens	175-194
25478949-0	2014	Characterization of zebrafish Abcc4 as an efflux transporter of organochlorine pesticides.	Hydrocarbons, Chlorinated	64-78	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Danio rerio	30-35
25585924-2	2015	We explored whether organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), were associated with hypermethylation of the MGMT gene promoter in peripheral leukocytes among 368 Koreans without cancer.	Hydrocarbons, Chlorinated	20-34	O-6-methylguanine-DNA methyltransferase	Homo sapiens	136-140
25911430-0	2015	Preparation of C18 composite solid-phase microextraction fiber and its application to the determination of organochlorine pesticides in water samples.	Hydrocarbons, Chlorinated	107-121	Bardet-Biedl syndrome 9	Homo sapiens	15-18
25911430-1	2015	In this work, a C18 composite solid-phase microextraction (SPME) fiber was prepared with a new method and applied to the analysis of organochlorine pesticides (OCPs) in water sample.	Hydrocarbons, Chlorinated	133-147	Bardet-Biedl syndrome 9	Homo sapiens	16-19
25633958-0	2015	Organochlorine insecticides induce NADPH oxidase-dependent reactive oxygen species in human monocytic cells via phospholipase A2/arachidonic acid.	Hydrocarbons, Chlorinated	0-14	phospholipase A2 group IB	Homo sapiens	112-128
25478949-2	2014	ABCC4/MRP4 is an organic anion transporter that mediates cellular efflux of a wide range of exogenous and endogenous compounds such as cyclic nucleotides and anti-cancer drugs; however, it remains unclear whether ABCC4 and its orthologs function in the detoxification of organochlorine pesticides.	Hydrocarbons, Chlorinated	271-285	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Danio rerio	0-5
25478949-8	2014	Thus, zebrafish Abcc4 plays crucial roles in cellular efflux of organochlorine pesticides and can be used a potential molecular marker for the monitor of DDT and lindane contamination in the aquatic environment.	Hydrocarbons, Chlorinated	64-78	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Danio rerio	16-21
25084496-0	2014	Interactions between polymorphisms in the aryl hydrocarbon receptor signalling pathway and exposure to persistent organochlorine pollutants affect human semen quality.	Hydrocarbons, Chlorinated	114-128	aryl hydrocarbon receptor	Homo sapiens	42-67
25113205-0	2014	Adjusting serum concentrations of organochlorine compounds by lipids and symptoms: a causal framework for the association with K-ras mutations in pancreatic cancer.	Hydrocarbons, Chlorinated	34-48	KRAS proto-oncogene, GTPase	Homo sapiens	127-132
25113205-2	2014	The aim of the study was to compare the effects of correcting for total serum lipids (TSL) and other clinical factors on the odds of mutations in the K-ras oncogene by organochlorine compounds (OCs), in logistic models, in 103 patients with exocrine pancreatic cancer (EPC) using a causal directed acyclic graph (DAG) framework.	Hydrocarbons, Chlorinated	168-182	KRAS proto-oncogene, GTPase	Homo sapiens	150-155
24740604-8	2014	Further supporting this is the fact that in COS-7 cells overexpressing STAR, the organochlorine mixture caused a decrease in the 30 kDa form of STAR and an accumulation of the 37 kDa forms.	Hydrocarbons, Chlorinated	81-95	steroidogenic acute regulatory protein	Mus musculus	71-75
25714637-7	2015	At an applied ozone dosage of 0.76 mgO3/mgCOD and an applied UV dosage of 3.427 Wh/m(3), the organochlorine compounds measured as AOX reached removal efficiencies of 40%.	Hydrocarbons, Chlorinated	93-107	acyl-CoA oxidase 1	Homo sapiens	130-133
24832206-3	2014	In the present work, we searched for interactions between endosulfan and methoxychlor, two organochlorine pesticides whose major routes of metabolism involve CAR- and PXR-regulated CYP3A4 and CYP2B6, and whose mechanisms of action in humans remain poorly understood.	Hydrocarbons, Chlorinated	91-105	nuclear receptor subfamily 1 group I member 3	Homo sapiens	158-161
24832206-3	2014	In the present work, we searched for interactions between endosulfan and methoxychlor, two organochlorine pesticides whose major routes of metabolism involve CAR- and PXR-regulated CYP3A4 and CYP2B6, and whose mechanisms of action in humans remain poorly understood.	Hydrocarbons, Chlorinated	91-105	nuclear receptor subfamily 1 group I member 2	Homo sapiens	167-170
24832206-3	2014	In the present work, we searched for interactions between endosulfan and methoxychlor, two organochlorine pesticides whose major routes of metabolism involve CAR- and PXR-regulated CYP3A4 and CYP2B6, and whose mechanisms of action in humans remain poorly understood.	Hydrocarbons, Chlorinated	91-105	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	181-187
24832206-3	2014	In the present work, we searched for interactions between endosulfan and methoxychlor, two organochlorine pesticides whose major routes of metabolism involve CAR- and PXR-regulated CYP3A4 and CYP2B6, and whose mechanisms of action in humans remain poorly understood.	Hydrocarbons, Chlorinated	91-105	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	192-198
24740604-8	2014	Further supporting this is the fact that in COS-7 cells overexpressing STAR, the organochlorine mixture caused a decrease in the 30 kDa form of STAR and an accumulation of the 37 kDa forms.	Hydrocarbons, Chlorinated	81-95	steroidogenic acute regulatory protein	Mus musculus	144-148
24740604-9	2014	In addition to STAR, we found that the organochlorine mixture also decreases the levels of CYP11A1 and ADXR, two proteins essential for the conversion of cholesterol into pregnenolone.	Hydrocarbons, Chlorinated	39-53	steroidogenic acute regulatory protein	Mus musculus	15-19
24740604-9	2014	In addition to STAR, we found that the organochlorine mixture also decreases the levels of CYP11A1 and ADXR, two proteins essential for the conversion of cholesterol into pregnenolone.	Hydrocarbons, Chlorinated	39-53	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	91-98
24584466-2	2014	The aim of the study was to examine the genetic polymorphism in cytochrome P450 2D6 (CYP2D6) and glutathione S-transferases pi 1 (GSTP1) with respect to organochlorine pesticides (OCPs) and metals in AD.	Hydrocarbons, Chlorinated	153-167	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	64-83
24584466-2	2014	The aim of the study was to examine the genetic polymorphism in cytochrome P450 2D6 (CYP2D6) and glutathione S-transferases pi 1 (GSTP1) with respect to organochlorine pesticides (OCPs) and metals in AD.	Hydrocarbons, Chlorinated	153-167	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	85-91
24584466-2	2014	The aim of the study was to examine the genetic polymorphism in cytochrome P450 2D6 (CYP2D6) and glutathione S-transferases pi 1 (GSTP1) with respect to organochlorine pesticides (OCPs) and metals in AD.	Hydrocarbons, Chlorinated	153-167	glutathione S-transferase pi 1	Homo sapiens	97-128
24584466-2	2014	The aim of the study was to examine the genetic polymorphism in cytochrome P450 2D6 (CYP2D6) and glutathione S-transferases pi 1 (GSTP1) with respect to organochlorine pesticides (OCPs) and metals in AD.	Hydrocarbons, Chlorinated	153-167	glutathione S-transferase pi 1	Homo sapiens	130-135
24530588-1	2014	Organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in surface soils along a transect from source areas (a petro-chemical industrial city, Lanzhou and its adjacent agricultural areas) to Ruoergai highland prairie (3,552 m above sea level (a.s.l.	Hydrocarbons, Chlorinated	0-14	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	246-249
23338993-3	2014	HCB, p,p"-DDE, PCB-138, PCB-153, and PCB-180, were the most abundant organochlorine compounds (OCs) detected in >95 % of the study subjects.	Hydrocarbons, Chlorinated	69-93	pyruvate carboxylase	Homo sapiens	15-18
23338993-3	2014	HCB, p,p"-DDE, PCB-138, PCB-153, and PCB-180, were the most abundant organochlorine compounds (OCs) detected in >95 % of the study subjects.	Hydrocarbons, Chlorinated	69-93	pyruvate carboxylase	Homo sapiens	24-27
23338993-3	2014	HCB, p,p"-DDE, PCB-138, PCB-153, and PCB-180, were the most abundant organochlorine compounds (OCs) detected in >95 % of the study subjects.	Hydrocarbons, Chlorinated	69-93	pyruvate carboxylase	Homo sapiens	24-27
24380025-1	2013	OBJECTIVES: To assess the Gene-Environmental interaction between maternal organochlorine pesticides (OCPs) level and CYP17 gene polymorphism with the risk of preterm delivery (PTD).	Hydrocarbons, Chlorinated	74-88	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	117-122
24161582-0	2014	Associations of organochlorine pesticides and polychlorinated biphenyls in visceral vs. subcutaneous adipose tissue with type 2 diabetes and insulin resistance.	Hydrocarbons, Chlorinated	16-30	insulin	Homo sapiens	141-148
24161582-8	2014	Some OC pesticides or PCBs, such as dichlorodiphenyltrichloroethanes (DDTs), chlordanes, and PCBs with 5 or less chlorides showed significant associations with diabetes or insulin resistance.	Hydrocarbons, Chlorinated	5-7	insulin	Homo sapiens	172-179
25101650-3	2014	OBJECTIVES: To examine the gene-gene and gene-environment interaction on PD risk with respect to gene polymorphism of cytochrome P450 2D6 (CYP2D6) and glutathione S-transferases pi 1 (GSTP1), organochlorine pesticides (OCPs) and metals.	Hydrocarbons, Chlorinated	192-206	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	118-137
24328544-0	2014	Residues and enantiomeric profiling of organochlorine pesticides in sediments from Xinghua Bay, southern East China Sea.	Hydrocarbons, Chlorinated	39-53	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	116-119
23333656-0	2013	Toxicokinetics of dioxins and other organochlorine compounds in Japanese people: association with hepatic CYP1A2 expression levels.	Hydrocarbons, Chlorinated	36-50	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	106-112
23653218-9	2013	Pathways and/or genes related to estrogen and STAT5 signaling were correlated to organochlorine exposures in both genders.	Hydrocarbons, Chlorinated	81-95	signal transducer and activator of transcription 5A	Homo sapiens	46-51
24096037-1	2013	1,1,1-Trichloro-2,2-bis(2-chlorophenyl-4-chlorophenyl)ethane (o,p"-DDT) is an organochlorine pesticide and endocrine disruptor known to activate the estrogen receptor.	Hydrocarbons, Chlorinated	78-92	estrogen receptor 1	Rattus norvegicus	149-166
23054273-0	2013	Levels, distribution, and risk assessment of organochlorines in surficial sediments of the Red Sea coast, Egypt.	Hydrocarbons, Chlorinated	45-60	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	95-98
23177004-0	2013	Organochlorine compounds in bovine milk from the state of Mato Grosso do Sul-Brazil.	Hydrocarbons, Chlorinated	0-14	Weaning weight-maternal milk	Bos taurus	35-39
23177004-3	2013	Here we determined the presence and concentration of organochlorine residues in pasteurized milk from Mato Grosso do Sul, Brazil, to monitor consumer exposure to these contaminants.	Hydrocarbons, Chlorinated	53-67	Weaning weight-maternal milk	Bos taurus	92-96
23177004-4	2013	Organochlorine pesticides in milk samples were analyzed using solid phase extraction in octadecyl silica-prepacked columns and identified by gas chromatography using an electron capture detector.	Hydrocarbons, Chlorinated	0-14	Weaning weight-maternal milk	Bos taurus	29-33
23169446-0	2013	Inhibition of human MDR1 and BCRP transporter ATPase activity by organochlorine and pyrethroid insecticides.	Hydrocarbons, Chlorinated	65-79	ATP binding cassette subfamily B member 1	Homo sapiens	20-24
22875286-0	2012	Residues of organochlorine pesticides in water and suspended particulate matter from Xiangshan Bay, East China Sea.	Hydrocarbons, Chlorinated	12-26	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	111-114
23596706-10	2013	CONCLUSION: Organochlorines resides, including DDT, HCH and PCB, may increase women"s risk of getting breast cancer.	Hydrocarbons, Chlorinated	12-27	pyruvate carboxylase	Homo sapiens	60-63
22829064-0	2012	Estrogen receptor alpha as a key target of organochlorines to promote angiogenesis.	Hydrocarbons, Chlorinated	43-58	estrogen receptor 1	Homo sapiens	0-23
22829064-11	2012	Altogether, these data highlight that organochlorines modulate cellular angiogenic processes through activation of ERalpha.	Hydrocarbons, Chlorinated	38-53	estrogen receptor 1	Homo sapiens	115-122
23132776-7	2012	Interestingly, the regulation of COX-2 by these organochlorines pesticides appears to be at the translational level.	Hydrocarbons, Chlorinated	48-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
22690917-0	2012	Photochemical molecular storage of Cl2, HCl, and COCl2: synthesis of organochlorine compounds, salts, ureas, and polycarbonate with photodecomposed chloroform.	Hydrocarbons, Chlorinated	69-83	endogenous retrovirus group W member 5	Homo sapiens	35-38
23169446-0	2013	Inhibition of human MDR1 and BCRP transporter ATPase activity by organochlorine and pyrethroid insecticides.	Hydrocarbons, Chlorinated	65-79	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	29-33
23169446-2	2013	The present study examined the effects of two classes of insecticides (organochlorine and pyrethroid) on the ATPase activity of the human multidrug resistance protein 1 (MDR1) and breast cancer resistance protein (BCRP) efflux transporters.	Hydrocarbons, Chlorinated	71-85	ATP binding cassette subfamily B member 1	Homo sapiens	138-168
23169446-2	2013	The present study examined the effects of two classes of insecticides (organochlorine and pyrethroid) on the ATPase activity of the human multidrug resistance protein 1 (MDR1) and breast cancer resistance protein (BCRP) efflux transporters.	Hydrocarbons, Chlorinated	71-85	ATP binding cassette subfamily B member 1	Homo sapiens	170-174
23169446-2	2013	The present study examined the effects of two classes of insecticides (organochlorine and pyrethroid) on the ATPase activity of the human multidrug resistance protein 1 (MDR1) and breast cancer resistance protein (BCRP) efflux transporters.	Hydrocarbons, Chlorinated	71-85	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	180-212
23169446-2	2013	The present study examined the effects of two classes of insecticides (organochlorine and pyrethroid) on the ATPase activity of the human multidrug resistance protein 1 (MDR1) and breast cancer resistance protein (BCRP) efflux transporters.	Hydrocarbons, Chlorinated	71-85	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	214-218
23169446-3	2013	Using plasma membranes from cells overexpressing MDR1 and BCRP, it was demonstrated that the organochlorine pesticide dichlorodiphenyltrichloroethane (DDT) (o,p"-DDT and p,p"-DDT isomers) as well as its metabolite (p,p"-dichlorodiphenyldichloroethane), inhibit both MDR1 and BCRP ATPase activity.	Hydrocarbons, Chlorinated	93-107	ATP binding cassette subfamily B member 1	Homo sapiens	49-53
23169446-3	2013	Using plasma membranes from cells overexpressing MDR1 and BCRP, it was demonstrated that the organochlorine pesticide dichlorodiphenyltrichloroethane (DDT) (o,p"-DDT and p,p"-DDT isomers) as well as its metabolite (p,p"-dichlorodiphenyldichloroethane), inhibit both MDR1 and BCRP ATPase activity.	Hydrocarbons, Chlorinated	93-107	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	58-62
23169446-3	2013	Using plasma membranes from cells overexpressing MDR1 and BCRP, it was demonstrated that the organochlorine pesticide dichlorodiphenyltrichloroethane (DDT) (o,p"-DDT and p,p"-DDT isomers) as well as its metabolite (p,p"-dichlorodiphenyldichloroethane), inhibit both MDR1 and BCRP ATPase activity.	Hydrocarbons, Chlorinated	93-107	ATP binding cassette subfamily B member 1	Homo sapiens	266-270
23169446-3	2013	Using plasma membranes from cells overexpressing MDR1 and BCRP, it was demonstrated that the organochlorine pesticide dichlorodiphenyltrichloroethane (DDT) (o,p"-DDT and p,p"-DDT isomers) as well as its metabolite (p,p"-dichlorodiphenyldichloroethane), inhibit both MDR1 and BCRP ATPase activity.	Hydrocarbons, Chlorinated	93-107	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	275-279
21331758-0	2011	Changing patterns of organochlorine pesticide residues in raw bovine milk from Haryana, India.	Hydrocarbons, Chlorinated	21-35	Weaning weight-maternal milk	Bos taurus	69-73
22509446-5	2012	RESULTS: Among the five subclasses of POPs, only organochlorine (OC) pesticides showed positive associations with CRP concentrations, while polychlorinated biphenyls (PCBs) showed inverse associations with CRP concentrations.	Hydrocarbons, Chlorinated	49-63	C-reactive protein	Homo sapiens	114-117
22509446-5	2012	RESULTS: Among the five subclasses of POPs, only organochlorine (OC) pesticides showed positive associations with CRP concentrations, while polychlorinated biphenyls (PCBs) showed inverse associations with CRP concentrations.	Hydrocarbons, Chlorinated	65-67	C-reactive protein	Homo sapiens	114-117
23022848-6	2012	RESULTS: The results confirmed the presence of high concentrations of insecticides, including organonitrogenous and organochlorine in tap drinking surface and ground water.	Hydrocarbons, Chlorinated	116-130	nuclear RNA export factor 1	Homo sapiens	134-137
21962179-8	2012	Moreover, the significant decrease in WBC count and lymphocytes added to depressed cytokine secretion, i.e., TNFalpha and IL-10, suggested an organochlorine-induced immunotoxicity in infants developmentally exposed to the agents.	Hydrocarbons, Chlorinated	142-156	tumor necrosis factor	Homo sapiens	109-117
21962179-8	2012	Moreover, the significant decrease in WBC count and lymphocytes added to depressed cytokine secretion, i.e., TNFalpha and IL-10, suggested an organochlorine-induced immunotoxicity in infants developmentally exposed to the agents.	Hydrocarbons, Chlorinated	142-156	interleukin 10	Homo sapiens	122-127
22055446-0	2012	The impact of organochlorines cycling in the cryosphere on their global distribution and fate--1.	Hydrocarbons, Chlorinated	14-29	fetal and adult testis expressed 1	Homo sapiens	89-96
21864959-0	2011	Assessment of organochlorine pesticide residues in Atlantic Rain Forest fragments, Rio de Janeiro, Brazil.	Hydrocarbons, Chlorinated	14-28	Ras interacting protein 1	Homo sapiens	60-64
21858705-0	2011	Organochlorine pesticides in muscle of wild seabass and Chinese prawn from the Bohai Sea and Yellow Sea, China.	Hydrocarbons, Chlorinated	0-14	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	85-88
21858705-0	2011	Organochlorine pesticides in muscle of wild seabass and Chinese prawn from the Bohai Sea and Yellow Sea, China.	Hydrocarbons, Chlorinated	0-14	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	100-103
21115097-6	2011	Although all of the pyrethroids and most of the organochlorines and acid amides acted as PXR agonists, a wide range of pesticides with diverse structures also showed hPXR and/or mPXR agonistic activity.	Hydrocarbons, Chlorinated	48-63	nuclear receptor subfamily 1 group I member 2	Homo sapiens	89-92
21620887-3	2011	Previously, we identified elevated serum levels of the organochlorine pesticide beta-hexachlorocyclohexane (beta-HCH) in PD patients from a small clinical sample.	Hydrocarbons, Chlorinated	55-69	nuclear receptor subfamily 0 group B member 1	Homo sapiens	108-116
21684540-13	2011	CONCLUSION: The patterns of associations between determinants and serum organochlorine concentrations suggest that human PCB contamination is still ongoing in France.	Hydrocarbons, Chlorinated	72-86	pyruvate carboxylase	Homo sapiens	121-124
20350743-0	2010	The relative influence of diet and serum concentrations of organochlorine compounds on K-ras mutations in exocrine pancreatic cancer.	Hydrocarbons, Chlorinated	59-73	KRAS proto-oncogene, GTPase	Homo sapiens	87-92
20965545-7	2011	Geometric means of serum concentrations (ng g-1 lipid) of organochlorine pesticides were 110.0, 19.1, and 33.5 for p,p"-DDE, beta-HCH, and HCB respectively, while the geometric means of PCBs were 21.8, 38.9 and 26.9 for PCB 138, 153, and 180 respectively.	Hydrocarbons, Chlorinated	58-72	pyruvate carboxylase	Homo sapiens	186-189
21207308-0	2011	Residues and chiral signatures of organochlorine pesticides in sediments from Xiangshan Bay, East China Sea.	Hydrocarbons, Chlorinated	34-48	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	104-107
21387926-3	2010	This study has been carried out to determine the level of organochlorine pesticides namely HCH, DDT and Endosulfan in raw fruit nuts.	Hydrocarbons, Chlorinated	58-72	D-dopachrome tautomerase	Homo sapiens	96-99
20435334-7	2010	These results suggest that AhR-mediated transcriptional activity of Inuit plasma extracts is linked to their organochlorine body burden, most likely that of dioxin-like PCBs, polychlorinated dibenzo-p-dioxins and polychlorodibenzofurans.	Hydrocarbons, Chlorinated	109-123	aryl hydrocarbon receptor	Homo sapiens	27-30
21366969-1	2011	This study has investigated the effect of two highly toxic pesticides, monocrotophos (organophosphate) and endosulphan (organochlorine), on the inducibility of two major heat shock proteins, the HSP60 and HSP70, essential for cell survival, in the house fly Musca domestica.	Hydrocarbons, Chlorinated	120-134	heat shock 70 kDa protein cognate 4	Musca domestica	205-210
21298090-0	2011	Low dose organochlorine pesticides and polychlorinated biphenyls predict obesity, dyslipidemia, and insulin resistance among people free of diabetes.	Hydrocarbons, Chlorinated	9-23	insulin	Homo sapiens	100-107
20558393-0	2010	Interaction between ABCB1 and professional exposure to organochlorine insecticides in Parkinson disease.	Hydrocarbons, Chlorinated	55-69	ATP binding cassette subfamily B member 1	Homo sapiens	20-25
20558393-11	2010	CONCLUSIONS: Our findings suggest that the ABCB1 gene and exposure to organochlorine insecticides interact to increase PD risk: in subjects professionally exposed to organochlorines, polymorphisms associated with a decreased ability of ABCB1 to clear xenobiotics from the brain increased the risk of PD.	Hydrocarbons, Chlorinated	70-84	ATP binding cassette subfamily B member 1	Homo sapiens	236-241
20558393-11	2010	CONCLUSIONS: Our findings suggest that the ABCB1 gene and exposure to organochlorine insecticides interact to increase PD risk: in subjects professionally exposed to organochlorines, polymorphisms associated with a decreased ability of ABCB1 to clear xenobiotics from the brain increased the risk of PD.	Hydrocarbons, Chlorinated	166-181	ATP binding cassette subfamily B member 1	Homo sapiens	43-48
20558393-11	2010	CONCLUSIONS: Our findings suggest that the ABCB1 gene and exposure to organochlorine insecticides interact to increase PD risk: in subjects professionally exposed to organochlorines, polymorphisms associated with a decreased ability of ABCB1 to clear xenobiotics from the brain increased the risk of PD.	Hydrocarbons, Chlorinated	166-181	ATP binding cassette subfamily B member 1	Homo sapiens	236-241
20861542-4	2010	According to the long-term monitoring program that has been carried out every third year between 1997-2009, the decreasing trend in EOX-concentrations in the top 2 cm of the bottom sediment reflects the decrease in organochlorine discharges (AOX) from the mills.	Hydrocarbons, Chlorinated	215-229	acyl-CoA oxidase 1	Homo sapiens	242-245
19821039-1	2010	BACKGROUND: Plasma organochlorines have been implicated to increase the risk of non-Hodgkin lymphoma (NHL), and interaction with the aryl hydrocarbon receptor gene (AHR) may modify this risk.	Hydrocarbons, Chlorinated	19-34	aryl hydrocarbon receptor	Homo sapiens	133-158
19821039-1	2010	BACKGROUND: Plasma organochlorines have been implicated to increase the risk of non-Hodgkin lymphoma (NHL), and interaction with the aryl hydrocarbon receptor gene (AHR) may modify this risk.	Hydrocarbons, Chlorinated	19-34	aryl hydrocarbon receptor	Homo sapiens	165-168
19821039-7	2010	CONCLUSION: Results suggest that the AHR gene may play a role in determining the risk of NHL with exposure to organochlorines, and highlight the importance of understanding gene-environment interactions.	Hydrocarbons, Chlorinated	110-125	aryl hydrocarbon receptor	Homo sapiens	37-40
20185977-1	2010	OBJECTIVES: This study was performed to investigate if organochlorine pesticides (OCPs) were associated with metabolic syndrome and insulin resistance among non-diabetes.	Hydrocarbons, Chlorinated	55-69	insulin	Homo sapiens	132-139
20387445-1	2010	By the method of SPE-GC/ECD, this paper studied the distribution and composition of organochlorine pesticides (OCPs) in the surface water body of Chaohu Lake.	Hydrocarbons, Chlorinated	84-98	ecdysoneless cell cycle regulator	Homo sapiens	17-27
19797353-0	2009	In pancreatic ductal adenocarcinoma blood concentrations of some organochlorine compounds and coffee intake are independently associated with KRAS mutations.	Hydrocarbons, Chlorinated	65-79	KRAS proto-oncogene, GTPase	Homo sapiens	142-146
19825792-4	2009	Supporting this concept, serum GGT within its normal range had clear dose-response associations with a variety of chemicals such as lead, cadmium, organochlorine pesticides, and dioxin.	Hydrocarbons, Chlorinated	147-161	gamma-glutamyltransferase light chain family member 3	Homo sapiens	31-34
19797353-2	2009	The objective was to test the hypothesis that in PDA there are aetiopathogenic relationships among concentrations of some organochlorine compounds (OCs) and the mutational status of the KRAS oncogene, as well as among the latter and coffee intake.	Hydrocarbons, Chlorinated	122-146	KRAS proto-oncogene, GTPase	Homo sapiens	186-190
19269724-0	2009	Organochlorine pesticide air-water exchange and bioconcentration in krill in the Ross Sea.	Hydrocarbons, Chlorinated	0-14	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	86-89
19595748-0	2009	Induction of CYP1A1, 2B, 2E1 and 3A in rat liver by organochlorine pesticide dicofol.	Hydrocarbons, Chlorinated	52-66	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	13-19
19219557-0	2009	A novel quantitative structure-activity relationship model for prediction of biomagnification factor of some organochlorine pollutants.	Hydrocarbons, Chlorinated	109-123	Bcl2 modifying factor	Homo sapiens	77-100
19219557-2	2009	In this work, quantitative structure-activity relationship (QSAR) models were used for the prediction of BMF for a data set including 30 polychlorinated biphenyls and 12 organochlorine pollutants.	Hydrocarbons, Chlorinated	170-184	Bcl2 modifying factor	Homo sapiens	105-108
19335881-0	2009	Multiple adverse thyroid and metabolic health signs in the population from the area heavily polluted by organochlorine cocktail (PCB, DDE, HCB, dioxin).	Hydrocarbons, Chlorinated	104-118	pyruvate carboxylase	Homo sapiens	129-132
19370474-5	2009	Supporting this concept, it was recently reported that serum GGT within its reference range was linearly associated with important environmental pollutants, including lead, cadmium, dioxin and organochlorine pesticides.	Hydrocarbons, Chlorinated	193-207	gamma-glutamyltransferase light chain family member 3	Homo sapiens	61-64
19916109-1	2009	Multiple linear regression and artificial neural networks (ANNs) as feature mapping techniques were used for the prediction of the biomagnification factor (BMF) of some organochlorine pollutants.	Hydrocarbons, Chlorinated	169-183	Bcl2 modifying factor	Homo sapiens	156-159
17888429-12	2008	CONCLUSION(S): The finding that PCB-77, PCB-105, PCB-153, and PCB-180 increased the expression of type I collagen in human normal peritoneal and adhesion fibroblasts is the first demonstration of involvement of organochlorines in the pathogenesis of tissue fibrosis.	Hydrocarbons, Chlorinated	211-226	pyruvate carboxylase	Homo sapiens	32-35
18791200-0	2009	Organochlorine-mediated potentiation of the general coactivator p300 through p38 mitogen-activated protein kinase.	Hydrocarbons, Chlorinated	0-14	E1A binding protein p300	Homo sapiens	64-68
18791200-0	2009	Organochlorine-mediated potentiation of the general coactivator p300 through p38 mitogen-activated protein kinase.	Hydrocarbons, Chlorinated	0-14	mitogen-activated protein kinase 14	Homo sapiens	77-113
18791200-2	2009	We have previously shown that the organochlorine pesticide dichlorodiphenyltrichloroethane (DDT) stimulates activator protein-1 activity through the p38 mitogen-activated protein kinase (MAPK).	Hydrocarbons, Chlorinated	34-48	mitogen-activated protein kinase 14	Homo sapiens	149-185
18787751-0	2008	Vitellogenin induction and increased plasma 17beta-estradiol concentrations in male Nile tilapia, Oreochromis niloticus, exposed to organochlorine pollutants and polycyclic aromatics hydrocarbons.	Hydrocarbons, Chlorinated	132-146	vitellogenin	Oreochromis niloticus	0-12
19256361-0	2008	[Source and distribution characteristic of atmospheric organochlorine pesticides in the Pearl River Estuary and adjacent South China Sea].	Hydrocarbons, Chlorinated	55-69	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	133-136
19057715-5	2008	We used linear regression models to measure the association between organochlorines and neurodevelopmental scores by GST polymorphisms.	Hydrocarbons, Chlorinated	68-83	glutathione S-transferase kappa 1	Homo sapiens	117-120
17888429-12	2008	CONCLUSION(S): The finding that PCB-77, PCB-105, PCB-153, and PCB-180 increased the expression of type I collagen in human normal peritoneal and adhesion fibroblasts is the first demonstration of involvement of organochlorines in the pathogenesis of tissue fibrosis.	Hydrocarbons, Chlorinated	211-226	pyruvate carboxylase	Homo sapiens	40-43
17888429-12	2008	CONCLUSION(S): The finding that PCB-77, PCB-105, PCB-153, and PCB-180 increased the expression of type I collagen in human normal peritoneal and adhesion fibroblasts is the first demonstration of involvement of organochlorines in the pathogenesis of tissue fibrosis.	Hydrocarbons, Chlorinated	211-226	pyruvate carboxylase	Homo sapiens	40-43
17888429-12	2008	CONCLUSION(S): The finding that PCB-77, PCB-105, PCB-153, and PCB-180 increased the expression of type I collagen in human normal peritoneal and adhesion fibroblasts is the first demonstration of involvement of organochlorines in the pathogenesis of tissue fibrosis.	Hydrocarbons, Chlorinated	211-226	pyruvate carboxylase	Homo sapiens	40-43
19103108-1	2008	OBJECTIVE: To study the potential effect of gene-environment interaction between glutathione S-transferase T1 (GSTT1) and serum organochlorines residues on the risk of breast cancer in women, in China.	Hydrocarbons, Chlorinated	128-143	glutathione S-transferase theta 1	Homo sapiens	81-109
18289828-4	2008	Eighty-five of the 543 chemicals, including 16 organochlorine pesticides, 14 styrene dimers, 9 monoalkylphenols and 6 parabens, exhibited RAR gamma agonistic effects in this assay.	Hydrocarbons, Chlorinated	47-61	retinoic acid receptor gamma	Homo sapiens	138-147
18387653-2	2008	Despite the prohibition of most persistent organochlorine pesticides in China, the presence of organochlorine residue, including DDT, has been widely indicated in environmental substance.	Hydrocarbons, Chlorinated	43-57	D-dopachrome tautomerase	Homo sapiens	129-132
18387653-2	2008	Despite the prohibition of most persistent organochlorine pesticides in China, the presence of organochlorine residue, including DDT, has been widely indicated in environmental substance.	Hydrocarbons, Chlorinated	95-109	D-dopachrome tautomerase	Homo sapiens	129-132
17564793-4	2008	According to the monitoring program carried out every third year between 1997-2006, the decreasing trend in EOX concentrations in the top 2 cm of the bottom sediment reflect the decrease in organochlorine discharges (AOX) from the mills.	Hydrocarbons, Chlorinated	190-204	acyl-CoA oxidase 1	Homo sapiens	217-220
18063141-1	2008	The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor through which organochlorine contaminants including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and some polycyclic aromatic hydrocarbons induce toxicity and altered gene expression.	Hydrocarbons, Chlorinated	93-107	aryl hydrocarbon receptor	Salmo salar	4-29
18063141-1	2008	The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor through which organochlorine contaminants including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and some polycyclic aromatic hydrocarbons induce toxicity and altered gene expression.	Hydrocarbons, Chlorinated	93-107	aryl hydrocarbon receptor	Salmo salar	31-34
17449539-7	2007	CYP1A1 and CYP1B1 polymorphisms may modify the relation between environmental exposure to organochlorine and advanced endometriosis risk.	Hydrocarbons, Chlorinated	90-104	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-6
17449539-7	2007	CYP1A1 and CYP1B1 polymorphisms may modify the relation between environmental exposure to organochlorine and advanced endometriosis risk.	Hydrocarbons, Chlorinated	90-104	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	11-17
17254622-1	2007	Cholinesterase inhibiting compounds such as carbamates and organophosphate insecticides have been widely used in agriculture since the ban on organochlorines in the 1970s.	Hydrocarbons, Chlorinated	142-157	cholinesterase	Columba livia	0-14
16919310-0	2006	Organochlorine pesticides and polychlorinated biphenyls in soil and water samples in the Northeastern part of Sao Paulo State, Brazil.	Hydrocarbons, Chlorinated	0-14	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	110-113
16616295-5	2006	The sum of PCB congeners (mean 8.9 ng l(-1)) showed the highest concentrations among the organochlorine compounds and atrazine (mean 82 ng l(-1)) among the polar pesticides.	Hydrocarbons, Chlorinated	89-113	pyruvate carboxylase	Homo sapiens	11-14
16480756-3	2006	Organochlorine compounds (OCs) were widely distributed in the Korean coastal environment, with PCB and DDT contamination being particularly prevalent.	Hydrocarbons, Chlorinated	0-14	pyruvate carboxylase	Homo sapiens	95-98
16647228-0	2006	In vitro modulation of HERG channels by organochlorine solvent trichlormethane as potential explanation for proarrhythmic effects of chloroform.	Hydrocarbons, Chlorinated	40-54	potassium voltage-gated channel subfamily H member 2	Homo sapiens	23-27
16403537-0	2006	Distribution of organochlorines in the dissolved and suspended phase of the sea-surface microlayer and seawater in Hong Kong, China.	Hydrocarbons, Chlorinated	16-31	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	76-79
16779578-7	2006	The level of total organochlorine pesticides in blood ranged from 3.319mg/L-6.253mg/L while in milk samples it ranged from 3.209Mdash;4.608 mg/L.	Hydrocarbons, Chlorinated	19-33	transmembrane 4 L six family member 1	Homo sapiens	74-77
16713641-4	2006	Many organochlorine compounds induce CYP3A expression in other vertebrates; hence, CYP3A induction by organochlorine contaminants could increase biotransformation and clearance of sex steroids by CYP3A and provide a plausible mechanism for the lowering of endogenous sex steroid concentrations in alligator plasma.	Hydrocarbons, Chlorinated	5-19	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	37-42
16713641-4	2006	Many organochlorine compounds induce CYP3A expression in other vertebrates; hence, CYP3A induction by organochlorine contaminants could increase biotransformation and clearance of sex steroids by CYP3A and provide a plausible mechanism for the lowering of endogenous sex steroid concentrations in alligator plasma.	Hydrocarbons, Chlorinated	5-19	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	83-88
16713641-4	2006	Many organochlorine compounds induce CYP3A expression in other vertebrates; hence, CYP3A induction by organochlorine contaminants could increase biotransformation and clearance of sex steroids by CYP3A and provide a plausible mechanism for the lowering of endogenous sex steroid concentrations in alligator plasma.	Hydrocarbons, Chlorinated	5-19	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	83-88
16713641-4	2006	Many organochlorine compounds induce CYP3A expression in other vertebrates; hence, CYP3A induction by organochlorine contaminants could increase biotransformation and clearance of sex steroids by CYP3A and provide a plausible mechanism for the lowering of endogenous sex steroid concentrations in alligator plasma.	Hydrocarbons, Chlorinated	102-116	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	37-42
16713641-4	2006	Many organochlorine compounds induce CYP3A expression in other vertebrates; hence, CYP3A induction by organochlorine contaminants could increase biotransformation and clearance of sex steroids by CYP3A and provide a plausible mechanism for the lowering of endogenous sex steroid concentrations in alligator plasma.	Hydrocarbons, Chlorinated	102-116	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	83-88
16713641-4	2006	Many organochlorine compounds induce CYP3A expression in other vertebrates; hence, CYP3A induction by organochlorine contaminants could increase biotransformation and clearance of sex steroids by CYP3A and provide a plausible mechanism for the lowering of endogenous sex steroid concentrations in alligator plasma.	Hydrocarbons, Chlorinated	102-116	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	83-88
16713641-5	2006	We used real time PCR to examine whether known and suspected CYP3A inducers (dexamethasone, metyrapone, rifampicin, and toxaphene) up-regulate steady state levels of hepatic CYP3A77 transcript to determine if induction patterns in female juvenile alligators are similar to those reported in other vertebrates and whether toxaphene, an organochlorine compound found in high concentrations in Lake Apopka alligators, induces this gene.	Hydrocarbons, Chlorinated	335-349	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	61-66
16713641-11	2006	In light of our findings, we hypothesized that higher steady state CYP3A77 (and possibly SXR) gene expression would be observed in alligators collected from Lake Apopka, a polluted lake containing organochlorine compounds known to induce CYP3A isoforms in other taxa.	Hydrocarbons, Chlorinated	197-211	nuclear receptor subfamily 1 group I member 2	Homo sapiens	89-92
16713641-11	2006	In light of our findings, we hypothesized that higher steady state CYP3A77 (and possibly SXR) gene expression would be observed in alligators collected from Lake Apopka, a polluted lake containing organochlorine compounds known to induce CYP3A isoforms in other taxa.	Hydrocarbons, Chlorinated	197-211	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	67-72
17100546-12	2006	When using categorical PCB values either >2000 (N=208) or >3000 (N=127) ng/g lipid, significant positive association (p<0.05 and p<0.01, respectively) was found between the sum of all organochlorines (PCB+DDE+HCB) and ThV, while that between PCB and ThV (p<0.01) was found only at the PCB levels >3000 ng/g lipid.	Hydrocarbons, Chlorinated	196-211	pyruvate carboxylase	Homo sapiens	23-26
16725033-1	2006	BACKGROUND: Persistent organic pollutants (POPs) such as polychlorinated dibenzo-p-dioxins/furans, polychlorinated biphenyls (PCBs) and organochlorine pesticides can cause a series of adverse effects on e.g. reproduction in animals and humans, many of which involve the aryl hydrocarbon receptor (AhR).	Hydrocarbons, Chlorinated	136-150	aryl hydrocarbon receptor	Homo sapiens	270-295
16725033-1	2006	BACKGROUND: Persistent organic pollutants (POPs) such as polychlorinated dibenzo-p-dioxins/furans, polychlorinated biphenyls (PCBs) and organochlorine pesticides can cause a series of adverse effects on e.g. reproduction in animals and humans, many of which involve the aryl hydrocarbon receptor (AhR).	Hydrocarbons, Chlorinated	136-150	aryl hydrocarbon receptor	Homo sapiens	297-300
16859517-0	2006	Estrogenic microenvironment generated by organochlorine residues in adipose mammary tissue modulates biomarker expression in ERalpha-positive breast carcinomas.	Hydrocarbons, Chlorinated	41-55	estrogen receptor 1	Homo sapiens	125-132
16859517-12	2006	More significantly, all the ERalpha-positive breast carcinomas from postmenopausal women exhibited high proliferation when organochlorine levels in the surrounding adipose tissue reached levels higher than 2600 ppb.	Hydrocarbons, Chlorinated	123-137	estrogen receptor 1	Homo sapiens	28-35
16859517-14	2006	CONCLUSION: The present results support the hypothesis that organochlorine residues in adipose tissue adjacent to breast carcinoma generate an estrogenic microenvironment that may influence the biological behavior of the tumor through ERalpha activation and ERalpha-dependent proliferation.	Hydrocarbons, Chlorinated	60-74	estrogen receptor 1	Homo sapiens	235-242
16859517-14	2006	CONCLUSION: The present results support the hypothesis that organochlorine residues in adipose tissue adjacent to breast carcinoma generate an estrogenic microenvironment that may influence the biological behavior of the tumor through ERalpha activation and ERalpha-dependent proliferation.	Hydrocarbons, Chlorinated	60-74	estrogen receptor 1	Homo sapiens	258-265
15710169-0	2005	Differential effects of the organochlorine pesticide DDT and its metabolite p,p"-DDE on p-glycoprotein activity and expression.	Hydrocarbons, Chlorinated	28-42	ATP binding cassette subfamily B member 1	Homo sapiens	88-102
16515477-8	2006	The organochlorine pesticides toxaphene and chlordane, and the synthetic compound XCT790 antagonize ERRalpha.	Hydrocarbons, Chlorinated	4-18	estrogen related receptor alpha	Homo sapiens	100-108
15885729-0	2005	Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR).	Hydrocarbons, Chlorinated	27-41	nuclear receptor subfamily 1 group I member 2	Homo sapiens	71-90
15885729-0	2005	Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR).	Hydrocarbons, Chlorinated	27-41	nuclear receptor subfamily 1 group I member 2	Homo sapiens	92-95
15885729-11	2005	Additionally, the evidence that organochlorine chemicals, particularly the ubiquitous triclosan, activate hPXR suggests that these environmental chemicals may, in part, exhibit their endocrine disruptor activities by altering PXR-regulated steroid hormone metabolism with potential adverse health effects in exposed individuals.	Hydrocarbons, Chlorinated	32-46	nuclear receptor subfamily 1 group I member 2	Homo sapiens	106-110
15885729-11	2005	Additionally, the evidence that organochlorine chemicals, particularly the ubiquitous triclosan, activate hPXR suggests that these environmental chemicals may, in part, exhibit their endocrine disruptor activities by altering PXR-regulated steroid hormone metabolism with potential adverse health effects in exposed individuals.	Hydrocarbons, Chlorinated	32-46	nuclear receptor subfamily 1 group I member 2	Homo sapiens	107-110
16024080-0	2005	Occurrence and distribution of organochlorine pesticides (HCH and DDT) in sediments collected from East China Sea.	Hydrocarbons, Chlorinated	31-45	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	110-113
15888667-3	2005	Organochlorine pesticides increased phosphorylated Raf, MEK1/2, ERK1/2, and c-Jun in human HaCaT cells, but they had no effect on p38 MAPK activation.	Hydrocarbons, Chlorinated	0-14	zinc fingers and homeoboxes 2	Homo sapiens	51-54
15888667-3	2005	Organochlorine pesticides increased phosphorylated Raf, MEK1/2, ERK1/2, and c-Jun in human HaCaT cells, but they had no effect on p38 MAPK activation.	Hydrocarbons, Chlorinated	0-14	mitogen-activated protein kinase kinase 1	Homo sapiens	56-62
15888667-3	2005	Organochlorine pesticides increased phosphorylated Raf, MEK1/2, ERK1/2, and c-Jun in human HaCaT cells, but they had no effect on p38 MAPK activation.	Hydrocarbons, Chlorinated	0-14	mitogen-activated protein kinase 3	Homo sapiens	64-70
15888667-3	2005	Organochlorine pesticides increased phosphorylated Raf, MEK1/2, ERK1/2, and c-Jun in human HaCaT cells, but they had no effect on p38 MAPK activation.	Hydrocarbons, Chlorinated	0-14	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	76-81
15589975-6	2005	In addition, organochlorine pesticides strongly induce cytochrome P450RAI1 (P450RAI1), a key factor of retinoic acid level regulation in many tissues and whose expression and activity are strongly induced by retinoic acid.	Hydrocarbons, Chlorinated	13-27	cytochrome P450 family 26 subfamily A member 1	Homo sapiens	66-74
15737364-0	2005	A preliminary report of persistent organochlorine pollutants in the Yellow Sea.	Hydrocarbons, Chlorinated	35-49	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	75-78
15589975-6	2005	In addition, organochlorine pesticides strongly induce cytochrome P450RAI1 (P450RAI1), a key factor of retinoic acid level regulation in many tissues and whose expression and activity are strongly induced by retinoic acid.	Hydrocarbons, Chlorinated	13-27	cytochrome P450 family 26 subfamily A member 1	Homo sapiens	76-84
15589975-0	2005	Activation of retinoic acid receptor-dependent transcription by organochlorine pesticides.	Hydrocarbons, Chlorinated	64-78	retinoic acid receptor alpha	Homo sapiens	14-36
15589975-1	2005	Five organochlorine pesticides, namely, chlordane, dieldrin, aldrin, endrin, and endosulfan, activate human retinoic acid receptor (RAR)-mediated gene transcription via a retinoic acid response element (RARE).	Hydrocarbons, Chlorinated	5-19	retinoic acid receptor alpha	Homo sapiens	108-130
15589975-1	2005	Five organochlorine pesticides, namely, chlordane, dieldrin, aldrin, endrin, and endosulfan, activate human retinoic acid receptor (RAR)-mediated gene transcription via a retinoic acid response element (RARE).	Hydrocarbons, Chlorinated	5-19	retinoic acid receptor alpha	Homo sapiens	132-135
15589975-3	2005	Five of the organochlorine pesticides tested activated RARbeta and RARgamma but not RARalpha; their half-maximal luciferase activity (EC(50)) was determined.	Hydrocarbons, Chlorinated	12-26	retinoic acid receptor beta	Homo sapiens	55-62
15589975-3	2005	Five of the organochlorine pesticides tested activated RARbeta and RARgamma but not RARalpha; their half-maximal luciferase activity (EC(50)) was determined.	Hydrocarbons, Chlorinated	12-26	retinoic acid receptor gamma	Homo sapiens	67-75
15589975-7	2005	This study shows that organochlorine pesticides can activate two RAR homologues, with low-binding affinity.	Hydrocarbons, Chlorinated	22-36	retinoic acid receptor alpha	Homo sapiens	65-68
12523960-9	2003	In the organochlorine-treated PC12 cells phosphorylation of p44/42 mitogen-activated protein kinase (MAPK) was upregulated, whereas phosphorylation bands were not detected in any kinases of other MAPK groups such as p38 MAPK and SAPK/JNK.	Hydrocarbons, Chlorinated	7-21	mitogen activated protein kinase 3	Rattus norvegicus	60-63
15541753-16	2004	The effect produced by these organochlorines in the liver correlates with the modulation of the ERalpha protein.	Hydrocarbons, Chlorinated	29-44	estrogen receptor 1 (alpha)	Mus musculus	96-103
15338091-1	2004	This paper describes the optimisation of a PSS injector in a gas chromatograph with a programmed pneumatic control (PPC) for the determination of 21 organochlorine pesticides.	Hydrocarbons, Chlorinated	149-163	PSS	Homo sapiens	43-46
15132331-1	2004	This study describes a fast activated carbon fiber-solid phase microextraction (ACF-SPME) method for determining organochlorine pesticides (OCPs) in water.	Hydrocarbons, Chlorinated	113-127	ACF	Homo sapiens	80-83
14604893-0	2004	Mechanism of AP-1-mediated gene expression by select organochlorines through the p38 MAPK pathway.	Hydrocarbons, Chlorinated	53-68	mitogen-activated protein kinase 14	Homo sapiens	81-84
14604893-7	2004	Using pharmacological and molecular inhibitors of the various MAPKs, we implicate the p38 signaling cascade, and to a lesser extent ERK, as necessary pathways for AP-1-mediated gene expression induction by organochlorines.	Hydrocarbons, Chlorinated	206-221	mitogen-activated protein kinase 14	Homo sapiens	86-89
14604893-8	2004	Taken together, these results demonstrate that organochlorines induce the collagenase promoter via sequential activation of the p38 kinase cascade and AP-1.	Hydrocarbons, Chlorinated	47-62	mitogen-activated protein kinase 14	Homo sapiens	128-131
15548381-7	2004	The abilities of organochlorine (OC), organophosphate (OP) and pyrethroid pesticides (PY) to activate hPXR were also assessed and found to be consistent with the abilities of these compounds to induce CYP3A4 and CYP2B6 in primary culture of human hepatocytes.	Hydrocarbons, Chlorinated	17-31	nuclear receptor subfamily 1 group I member 2	Homo sapiens	102-106
15548381-7	2004	The abilities of organochlorine (OC), organophosphate (OP) and pyrethroid pesticides (PY) to activate hPXR were also assessed and found to be consistent with the abilities of these compounds to induce CYP3A4 and CYP2B6 in primary culture of human hepatocytes.	Hydrocarbons, Chlorinated	33-35	nuclear receptor subfamily 1 group I member 2	Homo sapiens	102-106
15371232-1	2004	There are concerns that early life exposure to organochlorines, including aryl hydrocarbon receptor (AhR) agonists, may lead to long-term effects and increase the risk of developing breast cancer.	Hydrocarbons, Chlorinated	47-62	aryl hydrocarbon receptor	Rattus norvegicus	74-99
15371232-1	2004	There are concerns that early life exposure to organochlorines, including aryl hydrocarbon receptor (AhR) agonists, may lead to long-term effects and increase the risk of developing breast cancer.	Hydrocarbons, Chlorinated	47-62	aryl hydrocarbon receptor	Rattus norvegicus	101-104
15338091-0	2004	Improvement of sensitivity in the determination of organochlorine pesticides using a PSS injector with GC-ECD.	Hydrocarbons, Chlorinated	51-65	PSS	Homo sapiens	85-88
15183012-1	2004	Previously, we demonstrated that the organochlorine pesticide dieldrin induces mitochondrial depolarization, caspase-3 activation and apoptosis in dopaminergic PC12 cells.	Hydrocarbons, Chlorinated	37-51	caspase 3	Rattus norvegicus	109-118
15141140-8	2004	In general, women who carried inactive alleles of the GSTM1 had higher levels of breast organochlorines, and were at modestly increased risk of breast cancer (odds ratio = 2.2; 95% CI = 1.1-4.4).	Hydrocarbons, Chlorinated	88-103	glutathione S-transferase mu 1	Homo sapiens	54-59
15081270-0	2004	Effect of organochlorine pesticides on human androgen receptor activation in vitro.	Hydrocarbons, Chlorinated	10-24	androgen receptor	Homo sapiens	45-62
14514954-12	2004	This PCB/organochlorine pesticide mixture affects mortality, growth, thyroid function, and neurobehavioral development in rodents.	Hydrocarbons, Chlorinated	9-23	pyruvate carboxylase	Rattus norvegicus	5-8
14636698-3	2003	We have used the AhR-CALUX assay to investigate the AhR-mediated activity of the persistent organochlorine insecticide dieldrin and twenty-two pesticides currently used in Denmark by employing the rat H4IIE and the human TV101L hepatoma cell lines.	Hydrocarbons, Chlorinated	92-106	aryl hydrocarbon receptor	Rattus norvegicus	17-20
14636698-3	2003	We have used the AhR-CALUX assay to investigate the AhR-mediated activity of the persistent organochlorine insecticide dieldrin and twenty-two pesticides currently used in Denmark by employing the rat H4IIE and the human TV101L hepatoma cell lines.	Hydrocarbons, Chlorinated	92-106	aryl hydrocarbon receptor	Rattus norvegicus	52-55
14644672-9	2003	Our data support a negative association between TNF-alpha secretion by CBMCs and prenatal organochlorine exposure.	Hydrocarbons, Chlorinated	90-104	tumor necrosis factor	Homo sapiens	48-57
14644672-10	2003	If the relationship between organochlorine and TNF-alpha secretion is causal, it would suggest a role for this important proinflammatory cytokine in mediating organochlorine-induced immunotoxicity in infants developmentally exposed to these compounds.	Hydrocarbons, Chlorinated	28-42	tumor necrosis factor	Homo sapiens	47-56
14644672-10	2003	If the relationship between organochlorine and TNF-alpha secretion is causal, it would suggest a role for this important proinflammatory cytokine in mediating organochlorine-induced immunotoxicity in infants developmentally exposed to these compounds.	Hydrocarbons, Chlorinated	159-173	tumor necrosis factor	Homo sapiens	47-56
14636827-3	2003	We have previously demonstrated that the hepatotoxic chlorinated hydrocarbon, carbon tetrachloride, suppresses helper T-lymphocyte function in a TGF-beta(1)-dependent manner.	Hydrocarbons, Chlorinated	53-76	transforming growth factor, beta 1	Mus musculus	145-156
12557259-4	2003	Organochlorine compounds, organic solvents, and coffee compounds may play an indirect role in causing Ki-ras mutations, rather than as direct inducers of the mutations.	Hydrocarbons, Chlorinated	0-14	KRAS proto-oncogene, GTPase	Homo sapiens	102-108
12509046-4	2002	In comparison, their levels in the South China Sea were significantly lower, varying from 57.09-202 ng l(-1) for OCl insecticides, 21.72-144 ng l(-1) for PCBs, and 1.27-122 ng l(-1) for OP insecticides, respectively.	Hydrocarbons, Chlorinated	113-116	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	47-50
12909734-10	2003	A number of environmental and lifestyle factors, such as smoking, alcohol, coffee consumption, and exposure to organochlorine or hydrocarbon solvent, have been associated with the frequency and spectrum of K-ras mutation in pancreatic tumors.	Hydrocarbons, Chlorinated	111-125	KRAS proto-oncogene, GTPase	Homo sapiens	206-211
12167306-2	2002	The aim of this study was to assess the estrogenic activity of the organochlorine pesticides o,p"-DDT, dieldrin, aldrin, heptachlor, mirex and DDT in rainbow trout hepatocyte cultures using vitellogenin (Vtg) as the biomarker.	Hydrocarbons, Chlorinated	67-81	LOC100136735	Oncorhynchus mykiss	190-202
12417264-0	2002	PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides.	Hydrocarbons, Chlorinated	59-73	nuclear receptor subfamily 1 group I member 2	Homo sapiens	0-3
12417264-0	2002	PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides.	Hydrocarbons, Chlorinated	59-73	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	33-39
12167306-2	2002	The aim of this study was to assess the estrogenic activity of the organochlorine pesticides o,p"-DDT, dieldrin, aldrin, heptachlor, mirex and DDT in rainbow trout hepatocyte cultures using vitellogenin (Vtg) as the biomarker.	Hydrocarbons, Chlorinated	67-81	LOC100136735	Oncorhynchus mykiss	204-207
12088877-0	2002	Organochlorine pesticides directly regulate gonadotropin-releasing hormone gene expression and biosynthesis in the GT1-7 hypothalamic cell line.	Hydrocarbons, Chlorinated	0-14	gonadotropin releasing hormone 1	Mus musculus	44-74
11961215-5	2002	Changes in organochlorine concentrations were negatively associated with changes in serum T(3) concentration (significantly for p,p"-DDT, HCB, Aroclor 1260, PCB 28, PCB 99, PCB 118, and PCB 170) and with changes in RMR adjusted for weight loss (significantly for HCB and PCB 156).	Hydrocarbons, Chlorinated	11-25	pyruvate carboxylase	Homo sapiens	157-160
11961215-5	2002	Changes in organochlorine concentrations were negatively associated with changes in serum T(3) concentration (significantly for p,p"-DDT, HCB, Aroclor 1260, PCB 28, PCB 99, PCB 118, and PCB 170) and with changes in RMR adjusted for weight loss (significantly for HCB and PCB 156).	Hydrocarbons, Chlorinated	11-25	pyruvate carboxylase	Homo sapiens	165-168
11961215-5	2002	Changes in organochlorine concentrations were negatively associated with changes in serum T(3) concentration (significantly for p,p"-DDT, HCB, Aroclor 1260, PCB 28, PCB 99, PCB 118, and PCB 170) and with changes in RMR adjusted for weight loss (significantly for HCB and PCB 156).	Hydrocarbons, Chlorinated	11-25	pyruvate carboxylase	Homo sapiens	165-168
11961215-5	2002	Changes in organochlorine concentrations were negatively associated with changes in serum T(3) concentration (significantly for p,p"-DDT, HCB, Aroclor 1260, PCB 28, PCB 99, PCB 118, and PCB 170) and with changes in RMR adjusted for weight loss (significantly for HCB and PCB 156).	Hydrocarbons, Chlorinated	11-25	pyruvate carboxylase	Homo sapiens	165-168
11961215-5	2002	Changes in organochlorine concentrations were negatively associated with changes in serum T(3) concentration (significantly for p,p"-DDT, HCB, Aroclor 1260, PCB 28, PCB 99, PCB 118, and PCB 170) and with changes in RMR adjusted for weight loss (significantly for HCB and PCB 156).	Hydrocarbons, Chlorinated	11-25	pyruvate carboxylase	Homo sapiens	165-168
12088877-0	2002	Organochlorine pesticides directly regulate gonadotropin-releasing hormone gene expression and biosynthesis in the GT1-7 hypothalamic cell line.	Hydrocarbons, Chlorinated	0-14	retinoic acid induced 1	Mus musculus	115-118
12088877-3	2002	Two organochlorine pesticides (methoxychlor and chlorpyrifos) were tested for their effects on GnRH gene expression and biosynthesis in the immortalized hypothalamic GT1-7 cells, which synthesize and secrete GnRH.	Hydrocarbons, Chlorinated	4-18	gonadotropin releasing hormone 1	Mus musculus	95-99
12473173-0	2002	Inhibition of E2-induced expression of BRCA1 by persistent organochlorines.	Hydrocarbons, Chlorinated	59-74	BRCA1 DNA repair associated	Homo sapiens	39-44
11849040-0	2002	A molecular motif required for the activation of rat neutrophil phospholipase A(2) by organochlorine compounds.	Hydrocarbons, Chlorinated	86-100	phospholipase A2 group IB	Rattus norvegicus	64-81
11980446-0	2002	Persistent organochlorine residues in sediments from the Black Sea.	Hydrocarbons, Chlorinated	11-25	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	63-66
11859874-4	2002	This study examined if mutations in the tumor suppressor gene p53 affected organochlorine exposure related breast cancer risk and survival.	Hydrocarbons, Chlorinated	75-89	tumor protein p53	Homo sapiens	62-65
11859874-12	2002	These preliminary results suggest that p53 mutations may have a modifying effect on at least the breast cancer risk associated with exposures to organochlorines.	Hydrocarbons, Chlorinated	145-160	tumor protein p53	Homo sapiens	39-42
12473173-5	2002	METHODS: Using human breast cancer cell lines MCF-7 and MDA-MB-231, the effect on BRCA1 expression of chemicals belonging to different classes of organochlorine chemicals (the pesticide toxaphene, 2,3,7,8-tetrachlorodibenzo-p-dioxin, and three polychlorinated biphenyls [PCB#138, PCB#153 and PCB#180]) was measured by a reporter gene construct carrying 267 bp of the BRCA1 promoter.	Hydrocarbons, Chlorinated	146-160	BRCA1 DNA repair associated	Homo sapiens	82-87
10968381-1	2000	The authors analyzed the relation between lactation history, organochlorine serum levels-in particular, 2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane (DDT) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE)-and the risk of breast cancer within a subsampe from a larger breast cancer case-control study conducted among women living in Mexico City, Mexico, between 1990 and 1995.	Hydrocarbons, Chlorinated	61-75	D-dopachrome tautomerase	Homo sapiens	151-154
11829397-3	2002	The highest organochlorine load (up to 148 ng/g hair for the sum of PCB, DDT and hexachlorocyclohexane (HCH) isomers) was found in samples from a group of Greek women with past occupational exposure to pesticides.	Hydrocarbons, Chlorinated	12-26	pyruvate carboxylase	Homo sapiens	68-71
11808555-0	2002	Distribution of organochlorine pesticides in seawater of the Bering and Chukchi Sea.	Hydrocarbons, Chlorinated	16-30	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	80-83
11795388-4	2001	Using this model, several in vitro assays are developed that demonstrate that compounds from three major classes of xenoestrogens can mimic the effect of estrogen on leiomyoma cells and act as estrogen receptor (ER) agonists: phytoestrogens, organochlorine pesticides and pharmacologic agents.	Hydrocarbons, Chlorinated	242-256	estrogen receptor 1	Homo sapiens	212-214
11356845-5	2001	The mammalian cell transfection experiments revealed that the ERRalpha-1 mutant F329A, like wild-type ERalpha, recognized toxaphene (an organochlorine pesticide) as an agonist.	Hydrocarbons, Chlorinated	136-150	estrogen receptor 1	Homo sapiens	102-109
11561602-13	2001	K-ras mutation in pancreatic cancer has also been associated with alcohol consumption, organochlorines, and dietary habits.	Hydrocarbons, Chlorinated	87-102	KRAS proto-oncogene, GTPase	Homo sapiens	0-5
11222871-3	2001	In the human prostate cancer cell lines LNCaP and PC-3, erbB-2 kinase was activated by pesticides of different chemical classes: (1) the organochlorine insecticides beta-hexa-chlorocyclohexane (beta-HCH), o,p"-dichlorodiphenyltrichloroethane (o,p"-DDT), and heptachlor epoxide; (2) the pyrethroid insecticide trans-permethrin, and (3) the fungicide chlorothalonil.	Hydrocarbons, Chlorinated	137-151	chromobox 8	Homo sapiens	50-54
11222871-3	2001	In the human prostate cancer cell lines LNCaP and PC-3, erbB-2 kinase was activated by pesticides of different chemical classes: (1) the organochlorine insecticides beta-hexa-chlorocyclohexane (beta-HCH), o,p"-dichlorodiphenyltrichloroethane (o,p"-DDT), and heptachlor epoxide; (2) the pyrethroid insecticide trans-permethrin, and (3) the fungicide chlorothalonil.	Hydrocarbons, Chlorinated	137-151	erb-b2 receptor tyrosine kinase 2	Homo sapiens	56-62
11243318-5	2001	The residual concentrations of the organochlorines indicated nonexistence of the domestic sources of pollution by CHLs and elevated local contamination with PCBs.	Hydrocarbons, Chlorinated	35-50	LCS1	Homo sapiens	114-118
11787861-6	2001	The results suggest that stabilization of the native, phosphorylated form of connexin 43 by ChK may contribute to its ability to prevent organochlorine-induced inhibition of gap junction-mediated communication and dissolution of gap junction plaques within the plasma membrane.	Hydrocarbons, Chlorinated	137-151	gap junction protein alpha 1	Homo sapiens	77-88
11601531-10	2001	Other organochlorine compounds for which data are presented include: pp"-DDE, pp"-DDT, dieldrin, HCB, 3 chlorobenzenes and 3 PCB congeners.	Hydrocarbons, Chlorinated	6-20	pyruvate carboxylase	Homo sapiens	125-128
11912558-2	2002	In this study, we examined whether weight loss-induced changes in plasma organochlorine compounds (OC) were associated with those in plasma insulin levels.	Hydrocarbons, Chlorinated	73-97	insulin	Homo sapiens	140-147
11204696-8	2001	Trapezoidal area under the curve to the last time point values indicated that, during the trial, relative plasma organochlorine concentrations amounted to PCB-153 > DDE > OCDD.	Hydrocarbons, Chlorinated	113-127	pyruvate carboxylase	Bos taurus	155-158
10964798-4	2000	We previously showed that the organochlorine insecticide lindane and the organophosphate insecticide Dimethoate directly inhibit steroidogenesis in Leydig cells by disrupting expression of the steroidogenic acute regulatory (StAR) protein.	Hydrocarbons, Chlorinated	30-44	steroidogenic acute regulatory protein	Mus musculus	193-223
10964798-4	2000	We previously showed that the organochlorine insecticide lindane and the organophosphate insecticide Dimethoate directly inhibit steroidogenesis in Leydig cells by disrupting expression of the steroidogenic acute regulatory (StAR) protein.	Hydrocarbons, Chlorinated	30-44	steroidogenic acute regulatory protein	Mus musculus	225-229
10856020-6	2000	Results from studies on organochlorine contaminants (DDE/PCB) show that levels were not significantly different in breast cancer patients versus controls.	Hydrocarbons, Chlorinated	24-38	pyruvate carboxylase	Homo sapiens	57-60
10706031-4	2000	These findings are not inconsistent with the hypothesis derived from epidemiological work and animal studies that organochlorine insecticides produce a direct toxic action on the dopaminergic tracts of the substantia nigra and may contribute to the development of PD in those rendered susceptible by virtue of cytochrome P-450 polymorphism, excessive exposure, or other factors.	Hydrocarbons, Chlorinated	114-128	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	310-326
10696723-3	2000	Multiple linear regression indicated that the concentrations of PCB, p,p"-DDE, HCB and alpha-HCH decreased by 4-17% per year, suggesting that the decline in organochlorine concentrations in the Swedish environment and biota reported during the 1970s-1990s also has occurred in meat-producing animals during the 1990s.	Hydrocarbons, Chlorinated	157-171	pyruvate carboxylase	Bos taurus	64-67
10544157-0	1999	Cord serum immunoglobulin E related to the environmental contamination of human placentas with organochlorine compounds.	Hydrocarbons, Chlorinated	95-109	immunoglobulin heavy constant epsilon	Homo sapiens	11-27
10698481-9	2000	Serum levels of all of these organochlorines significantly decreased between initiation and completion of chemotherapy, 25% for total PCB (P = 0.0044), 28% for DDE (P = 0.0014), 25% for PCB-138 (P = 0.0053), 27% for PCB-153 (P = 0.0031), and 29% for PCB-156 (P = 0.045).	Hydrocarbons, Chlorinated	29-44	pyruvate carboxylase	Homo sapiens	134-137
10698481-9	2000	Serum levels of all of these organochlorines significantly decreased between initiation and completion of chemotherapy, 25% for total PCB (P = 0.0044), 28% for DDE (P = 0.0014), 25% for PCB-138 (P = 0.0053), 27% for PCB-153 (P = 0.0031), and 29% for PCB-156 (P = 0.045).	Hydrocarbons, Chlorinated	29-44	pyruvate carboxylase	Homo sapiens	186-189
10698481-9	2000	Serum levels of all of these organochlorines significantly decreased between initiation and completion of chemotherapy, 25% for total PCB (P = 0.0044), 28% for DDE (P = 0.0014), 25% for PCB-138 (P = 0.0053), 27% for PCB-153 (P = 0.0031), and 29% for PCB-156 (P = 0.045).	Hydrocarbons, Chlorinated	29-44	pyruvate carboxylase	Homo sapiens	186-189
10698481-9	2000	Serum levels of all of these organochlorines significantly decreased between initiation and completion of chemotherapy, 25% for total PCB (P = 0.0044), 28% for DDE (P = 0.0014), 25% for PCB-138 (P = 0.0053), 27% for PCB-153 (P = 0.0031), and 29% for PCB-156 (P = 0.045).	Hydrocarbons, Chlorinated	29-44	pyruvate carboxylase	Homo sapiens	186-189
10653519-3	2000	Therefore, studies were performed to determine if the organochlorine pesticides, lindane and dieldrin, activate neutrophils to produce O2- by a mechanism that requires PLA2.	Hydrocarbons, Chlorinated	54-68	phospholipase A2 group IB	Homo sapiens	168-172
10609819-5	1999	We analysed the relation between serum concentrations of selected organochlorine compounds and mutations in codon 12 of the K-ras gene in patients with exocrine pancreatic cancer.	Hydrocarbons, Chlorinated	66-80	KRAS proto-oncogene, GTPase	Homo sapiens	124-129
10609819-17	1999	INTERPRETATION: Organochlorine compounds such as p,p"-DDT, p,p"-DDE, and some PCBs could play a part in the pathogenesis of exocrine pancreatic cancer through modulation of K-ras activation.	Hydrocarbons, Chlorinated	16-30	KRAS proto-oncogene, GTPase	Homo sapiens	173-178
10544157-11	1999	The findings pointed to an association between organochlorine compounds and the higher levels of total IgE in newborns, signaling a higher allergic sensitization in the industrial region.	Hydrocarbons, Chlorinated	47-61	immunoglobulin heavy constant epsilon	Homo sapiens	103-106
10473799-8	1999	Calculating the concentrations of organochlorine compounds in relation to the content of apoB, the levels were about 10 times higher in VLDL than in LDL.	Hydrocarbons, Chlorinated	34-48	apolipoprotein B	Homo sapiens	89-93
10090705-0	1999	Potential mechanisms of thyroid disruption in humans: interaction of organochlorine compounds with thyroid receptor, transthyretin, and thyroid-binding globulin.	Hydrocarbons, Chlorinated	69-83	transthyretin	Homo sapiens	117-130
10502498-0	1999	Cytotoxicity and aromatase (CYP19) activity modulation by organochlorines in human placental JEG-3 and JAR choriocarcinoma cells.	Hydrocarbons, Chlorinated	58-73	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	28-33
10499361-2	1999	Here we report that subchronic administration of the organochlorine insecticide heptachlor (0, 3, 6, 9, or 12 mg/kg given 3 times over a 2 week period) leads to a pronounced increase in both the plasma membrane transport of dopamine and the expression of the plasma membrane dopamine transporter (DAT), as well as the vesicular monoamine transporter (VMAT2) in the striatum of C57BL mice.	Hydrocarbons, Chlorinated	53-67	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	275-295
10499361-2	1999	Here we report that subchronic administration of the organochlorine insecticide heptachlor (0, 3, 6, 9, or 12 mg/kg given 3 times over a 2 week period) leads to a pronounced increase in both the plasma membrane transport of dopamine and the expression of the plasma membrane dopamine transporter (DAT), as well as the vesicular monoamine transporter (VMAT2) in the striatum of C57BL mice.	Hydrocarbons, Chlorinated	53-67	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	297-300
10499361-2	1999	Here we report that subchronic administration of the organochlorine insecticide heptachlor (0, 3, 6, 9, or 12 mg/kg given 3 times over a 2 week period) leads to a pronounced increase in both the plasma membrane transport of dopamine and the expression of the plasma membrane dopamine transporter (DAT), as well as the vesicular monoamine transporter (VMAT2) in the striatum of C57BL mice.	Hydrocarbons, Chlorinated	53-67	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	351-356
10419232-11	1999	Through epidemiological studies it may be possible to obtain information about to what extent exposure to environmental pollution from organochlorines contributes to the poor health of people living in the Aral Sea region.	Hydrocarbons, Chlorinated	135-150	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	211-214
10330311-0	1999	Cytochrome P450 CYP1A1 enzyme activity and DNA adducts in placenta of women environmentally exposed to organochlorines.	Hydrocarbons, Chlorinated	103-118	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	0-22
10330311-11	1999	This study confirms that CYP1A1 enzyme induction and DNA adducts in placental tissue constitute useful biomarkers of early effects induced by environmental exposure to organochlorines.	Hydrocarbons, Chlorinated	168-183	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	25-31
10227188-0	1999	Rapid screening for organochlorine and organophosphorus pesticides in milk using C18 and graphitized carbon black solid phase extraction cleanup.	Hydrocarbons, Chlorinated	20-34	Bardet-Biedl syndrome 9	Homo sapiens	81-84
10605876-0	1999	Determination of organochlorine pesticide residues in honey, applying solid phase extraction with RP-C18 material.	Hydrocarbons, Chlorinated	17-31	RNA polymerase II, I and III subunit H	Homo sapiens	98-104
10090705-2	1999	Hydroxylated organochlorines have relatively high affinities for the serum transport protein transthyretin, but the ability of these compounds to interact with the human thyroid receptor is unknown.	Hydrocarbons, Chlorinated	13-28	transthyretin	Homo sapiens	93-106
10903110-4	1999	Analysis of rain and snow collected at different sites in Europe showed that organochlorines were responsible for the major part of the AOX content in all samples collected.	Hydrocarbons, Chlorinated	77-92	acyl-CoA oxidase 1	Homo sapiens	136-139
10197484-1	1999	OBJECTIVES: The aim of the present study was to assess whether a high dietary intake of fatty fish from the Baltic Sea, contaminated with persistent organochlorine compounds, might increase the risk for congenital malformations and perinatal death.	Hydrocarbons, Chlorinated	149-173	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	115-118
10487416-0	1999	Correlation between the activation of Neu tyrosine kinase and promotion of foci formation induced by selected organochlorine compounds in the MCF-7 model system.	Hydrocarbons, Chlorinated	110-124	erb-b2 receptor tyrosine kinase 2	Homo sapiens	38-41
10092429-9	1999	Certain organochlorine levels, specifically total PCB (estimated by plasma Aroclor 1260), p,p"-DDT, p,p"-DDE, and B-BHC, were highest in the Bangladeshis compared to Vietnamese and to majority-community sportfishers.	Hydrocarbons, Chlorinated	8-22	pyruvate carboxylase	Homo sapiens	50-53
10048758-9	1999	These results suggest that members of the organochlorine class are able to downregulate Rb expression at the post-transcriptional level, an effect similar to that on p53 tumor suppressor previously reported by our laboratory.	Hydrocarbons, Chlorinated	42-56	RB transcriptional corepressor 1	Homo sapiens	88-90
10048758-9	1999	These results suggest that members of the organochlorine class are able to downregulate Rb expression at the post-transcriptional level, an effect similar to that on p53 tumor suppressor previously reported by our laboratory.	Hydrocarbons, Chlorinated	42-56	tumor protein p53	Homo sapiens	166-169
10487416-4	1999	We also found that organochlorines result in an increase of Neu protein tyrosine kinase after intact cell treatment in estrogen-depleted medium.	Hydrocarbons, Chlorinated	19-34	erb-b2 receptor tyrosine kinase 2	Homo sapiens	60-63
10487416-8	1999	Those two events induced by organochlorines (i.e., Neu kinase activation and foci formation) seemed causally correlated.	Hydrocarbons, Chlorinated	28-43	erb-b2 receptor tyrosine kinase 2	Homo sapiens	51-54
9855641-3	1998	Transient co-transfection of LLC-PK1 cells with (CYP3A23)2-tk-CAT and mouse PXR demonstrated that the organochlorine pesticides transnonachlor and chlordane and the nonplanar polychlorinated biphenyls (PCBs) each induced the CYP3A23 DR-3 element, and this activation required PXR.	Hydrocarbons, Chlorinated	102-116	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	49-56
9855641-3	1998	Transient co-transfection of LLC-PK1 cells with (CYP3A23)2-tk-CAT and mouse PXR demonstrated that the organochlorine pesticides transnonachlor and chlordane and the nonplanar polychlorinated biphenyls (PCBs) each induced the CYP3A23 DR-3 element, and this activation required PXR.	Hydrocarbons, Chlorinated	102-116	nuclear receptor subfamily 1, group I, member 2	Mus musculus	76-79
9855641-3	1998	Transient co-transfection of LLC-PK1 cells with (CYP3A23)2-tk-CAT and mouse PXR demonstrated that the organochlorine pesticides transnonachlor and chlordane and the nonplanar polychlorinated biphenyls (PCBs) each induced the CYP3A23 DR-3 element, and this activation required PXR.	Hydrocarbons, Chlorinated	102-116	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	225-232
9855641-3	1998	Transient co-transfection of LLC-PK1 cells with (CYP3A23)2-tk-CAT and mouse PXR demonstrated that the organochlorine pesticides transnonachlor and chlordane and the nonplanar polychlorinated biphenyls (PCBs) each induced the CYP3A23 DR-3 element, and this activation required PXR.	Hydrocarbons, Chlorinated	102-116	nuclear receptor subfamily 1, group I, member 2	Mus musculus	276-279
9818392-1	1998	Octadecyl (C18)-bonded porous silica was evaluated for the extraction of triazines, organochlorine, carbamates and acidic pesticides from surface and ground water.	Hydrocarbons, Chlorinated	84-98	Bardet-Biedl syndrome 9	Homo sapiens	11-14
9443065-5	1998	Moreover, these organochlorines were found to activate PTK even under cell-free conditions, indicating that they are likely to interact directly with the target protein tyrosine kinase.	Hydrocarbons, Chlorinated	16-31	protein tyrosine kinase 2 beta	Homo sapiens	55-58
9641493-11	1998	Either serum or adipose OCP/PCB levels of a variety of environmental organochlorine compounds may serve as useful biomarkers of body burden.	Hydrocarbons, Chlorinated	69-83	pyruvate carboxylase	Homo sapiens	28-31
9443065-6	1998	As a result of immunoprecipitation with specific antibodies, and testing on the action of these organochlorines, we could show that the major kinase activated by o,p"-DDT is c-Neu (= c-erbB2 product protein).	Hydrocarbons, Chlorinated	96-111	erb-b2 receptor tyrosine kinase 2	Homo sapiens	183-190
9392618-3	1997	We compared the effects of organochlorines belonging to the DDT and PCB families, alone and in combination, for their ability to influence the estrogen receptor-mediated activities in preneoplastic breast epithelial cells and breast cancer cells.	Hydrocarbons, Chlorinated	27-42	estrogen receptor 1	Homo sapiens	143-160
9392618-8	1997	CONCLUSION: p,p"-DDT is the most effective organochlorine in regulating estrogen receptor-mediated cellular responses.	Hydrocarbons, Chlorinated	43-57	estrogen receptor 1	Homo sapiens	72-89
7513451-1	1994	We previously reported that when primary cultures of rat hepatocytes were treated with phenobarbital (PB) or one of several organochlorine pesticides, including Mirex, there was co-induction of cytochrome P450 2B1 and 2B2 mRNAs and immunoreactive proteins, whereas Kepone selectively induced 2B2 (Kocarek et al.	Hydrocarbons, Chlorinated	124-138	cytochrome P450 2B1	Rattus norvegicus	194-221
9496644-0	1997	Role of the estrogen receptor in the action of organochlorine pesticides on estrogen metabolism in human breast cancer cell lines.	Hydrocarbons, Chlorinated	47-61	estrogen receptor 1	Homo sapiens	12-29
9419265-1	1997	A positive association has been reported between elevated tissue organochlorines (p,p"-DDT/p,p"-DDE, PCBs, dioxins) and breast cancer in some case-control studies and occupational cohort studies.	Hydrocarbons, Chlorinated	65-80	D-dopachrome tautomerase	Homo sapiens	87-90
9475050-0	1997	Modulation of gamma glutamyl transpeptidase activity in lymphoid system by organochlorine pesticides in rats.	Hydrocarbons, Chlorinated	75-89	gamma-glutamyltransferase 1	Rattus norvegicus	14-43
8759309-0	1996	Metabolism of organochlorine pesticides: the role of human cytochrome P450 3A4.	Hydrocarbons, Chlorinated	14-28	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	59-78
7850393-1	1994	Oxygen containing C-3 chlorohydrocarbons are secondary products of C-3 chlorohydrocarbons formed during oxidation at air, in the metabolism of pesticides and by chlorination of drinking water.	Hydrocarbons, Chlorinated	22-40	complement C3	Homo sapiens	18-21
7850393-1	1994	Oxygen containing C-3 chlorohydrocarbons are secondary products of C-3 chlorohydrocarbons formed during oxidation at air, in the metabolism of pesticides and by chlorination of drinking water.	Hydrocarbons, Chlorinated	22-40	complement C3	Homo sapiens	67-70
7850393-1	1994	Oxygen containing C-3 chlorohydrocarbons are secondary products of C-3 chlorohydrocarbons formed during oxidation at air, in the metabolism of pesticides and by chlorination of drinking water.	Hydrocarbons, Chlorinated	71-89	complement C3	Homo sapiens	18-21
7850393-1	1994	Oxygen containing C-3 chlorohydrocarbons are secondary products of C-3 chlorohydrocarbons formed during oxidation at air, in the metabolism of pesticides and by chlorination of drinking water.	Hydrocarbons, Chlorinated	71-89	complement C3	Homo sapiens	67-70
7523654-1	1994	Lindane (gamma-hexachlorocyclohexane) is an organochlorine pesticide that increases intracellular free calcium ([Ca++]i) in several tissues.	Hydrocarbons, Chlorinated	44-58	carbonic anhydrase 1	Rattus norvegicus	113-119
7528509-2	1994	The decreasing tendency of the contamination of human milk with residues of organochlorine compounds (DDT, HCH, HCB, PCB) has been confirmed by our investigations also for the territory of the former GDR.	Hydrocarbons, Chlorinated	76-90	pyruvate carboxylase	Homo sapiens	117-120
9200862-2	1997	Of the 175 mothers" milk samples analysed, the organochlorine pesticide residues were detected in the following order of frequency: pp-DDE, 100%, pp-DDT 98%; and sum PCB, 53%.	Hydrocarbons, Chlorinated	47-61	pyruvate carboxylase	Homo sapiens	166-169
9194340-4	1997	In particular, we found that 50% effective concentration of the mixture of the organochlorine chemicals was considered only about 7 times greater level over the average concentration in the healthy people, namely 70ppt as 2, 3, 7, 8-TCDD, in the absence of ANF and about 5 times more than that in the presence of ANF.	Hydrocarbons, Chlorinated	79-93	natriuretic peptide A	Homo sapiens	257-260
9194340-4	1997	In particular, we found that 50% effective concentration of the mixture of the organochlorine chemicals was considered only about 7 times greater level over the average concentration in the healthy people, namely 70ppt as 2, 3, 7, 8-TCDD, in the absence of ANF and about 5 times more than that in the presence of ANF.	Hydrocarbons, Chlorinated	79-93	natriuretic peptide A	Homo sapiens	313-316
21639233-0	1997	Optimization of SFE for the Determination of Chlorinated Hydrocarbons at the Part-per-Trillion Level.	Hydrocarbons, Chlorinated	45-69	membrane metalloendopeptidase	Homo sapiens	16-19
8714222-3	1996	DDT and PCB are used as model organochlorines with the caveat that there may be thousands of other chemicals in the environment also involved.	Hydrocarbons, Chlorinated	30-45	pyruvate carboxylase	Homo sapiens	8-11
1536596-0	1992	Organochlorine pesticide residues in human milk in the Ribeirao Preto region, state of Sao Paulo, Brazil.	Hydrocarbons, Chlorinated	0-14	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	87-90
1382176-2	1992	c-fos has been found activated after the administration of the organochlorine insecticide lindane, the Ca2+ channel agonist Bay K, and N-methyl-D-aspartate (NMDA).	Hydrocarbons, Chlorinated	63-77	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-5
8478982-3	1993	Polychlorinated biphenyls (PCBs) and related organochlorine compounds deplete vitamin A and thyroxine by interaction with TTR and alteration of their metabolism in hepatic and other organs.	Hydrocarbons, Chlorinated	45-59	transthyretin	Rattus norvegicus	122-125
1380685-2	1992	The organochlorine insecticide gamma-hexachlorocyclohexane (lindane) has been shown to induce c-fos expression in a dose dependent manner.	Hydrocarbons, Chlorinated	4-18	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	94-99
1371151-2	1992	The organochlorine insecticide gamma-hexachlorocyclohexane (gamma-HCH, lindane) has been shown to induce c-fos expression in different brain areas.	Hydrocarbons, Chlorinated	4-18	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	105-110
2866919-6	1985	These results give evidence of cytochrome P-450 forms which can metabolize organochlorine compounds at low substrate concentrations.	Hydrocarbons, Chlorinated	75-99	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	31-47
2359402-3	1990	We have previously shown that a P450 mRNA that is homologous to rat liver P450IIB1 (P450b) is expressed in rat small intestine and is inducible by phenobarbital, polyhalogenated biphenyls, and organochlorine pesticides.	Hydrocarbons, Chlorinated	193-207	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	84-89
34688840-0	2021	Organochlorine pesticide dieldrin upregulate proximal promoter (PII) driven CYP19A1 gene expression and increases estrogen production in granulosa cells.	Hydrocarbons, Chlorinated	0-14	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	76-83
34688840-1	2021	Organochlorine pesticides are highly persistent environmental pollutants, generally shown to act through estrogen receptor alpha and alter estrogen biosynthesis.	Hydrocarbons, Chlorinated	0-14	estrogen receptor 1	Homo sapiens	105-128
34116183-7	2021	Importantly several TICs showed potent inhibition of Ta-ABCB1, such as the organochlorine pesticides Endrin (EC50 = 1.2 +- 0.2 muM) and Mirex (EC50 = 2.3 +- 0.9 muM).	Hydrocarbons, Chlorinated	75-89	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	56-61
35597001-0	2022	Occurrence, origin and potential ecological risk of dissolved polycyclic aromatic hydrocarbons and organochlorines in surface waters of the Gulf of Gabes (Tunisia, Southern Mediterranean Sea).	Hydrocarbons, Chlorinated	99-114	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	187-190
3132464-0	1988	Expression of cytochrome P450b and P450e genes in small intestinal mucosa of rats following treatment with phenobarbital, polyhalogenated biphenyls, and organochlorine pesticides.	Hydrocarbons, Chlorinated	153-167	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	14-30
3541787-1	1986	We purified a hepatic aldehyde reductase (AR1) and two carbonyl reductases (CR1, CR2) from the Mongolian gerbil, an animal recently shown to closely resemble man in its metabolism of a carbonyl containing organochlorine pesticide.	Hydrocarbons, Chlorinated	205-219	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	76-79
3922334-6	1985	The experimental evidence indicated that AHH inducibility by the organochlorine compounds reflected the genetic susceptibility of the cells to the phenomenon of induction, and PCDF isomers found at relatively high concentrations in tissues of mammals exerted the highest values of AHH induction.	Hydrocarbons, Chlorinated	65-79	aryl hydrocarbon receptor repressor	Homo sapiens	41-44
1696103-0	1990	[Residues of organochlorine insecticides in human and bovine milk in Colombia].	Hydrocarbons, Chlorinated	13-27	Weaning weight-maternal milk	Bos taurus	61-65
1696103-1	1990	Studies carried out in various countries have determined the presence of organochlorine insecticides in human and cow"s milk.	Hydrocarbons, Chlorinated	73-87	Weaning weight-maternal milk	Bos taurus	120-124
35435442-6	2022	Their AOX daily mass loadings (151 and 55.4 g/day/1000people) and mass emissions into the environment (47.8 and 23.5 g/day/1000 people) for both locations were correlated with the concentration level of volatile organic compounds, chlorophenols, organochlorine pesticides and polychlorinated biphenyls from both wastewater and sewage sludge, respectively.	Hydrocarbons, Chlorinated	246-260	acyl-CoA oxidase 1	Homo sapiens	6-9
35420343-1	2022	Our previous gene expression studies in a PCB-exposed cohort of young children in Slovakia revealed that early-life exposures to PCBs and other organochlorine compounds were associated with significant alterations across several pathogenetic pathways.	Hydrocarbons, Chlorinated	144-158	pyruvate carboxylase	Homo sapiens	42-45
15092629-1	1988	Treatment with Aldrin, an organochlorine insecticide, for 13 and 26 days caused suppression of 3beta-hydroxysteroid dehydrogenase (3beta-HSD) and 17beta-hydroxysteroid dehydrogenase (17beta-HSD) activities, along with accumulation of cholesterol in the testicular tissues of adult rats.	Hydrocarbons, Chlorinated	26-40	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	95-129
15092629-1	1988	Treatment with Aldrin, an organochlorine insecticide, for 13 and 26 days caused suppression of 3beta-hydroxysteroid dehydrogenase (3beta-HSD) and 17beta-hydroxysteroid dehydrogenase (17beta-HSD) activities, along with accumulation of cholesterol in the testicular tissues of adult rats.	Hydrocarbons, Chlorinated	26-40	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	131-140
15092629-1	1988	Treatment with Aldrin, an organochlorine insecticide, for 13 and 26 days caused suppression of 3beta-hydroxysteroid dehydrogenase (3beta-HSD) and 17beta-hydroxysteroid dehydrogenase (17beta-HSD) activities, along with accumulation of cholesterol in the testicular tissues of adult rats.	Hydrocarbons, Chlorinated	26-40	aldo-keto reductase family 1, member C12	Rattus norvegicus	146-181
15092629-1	1988	Treatment with Aldrin, an organochlorine insecticide, for 13 and 26 days caused suppression of 3beta-hydroxysteroid dehydrogenase (3beta-HSD) and 17beta-hydroxysteroid dehydrogenase (17beta-HSD) activities, along with accumulation of cholesterol in the testicular tissues of adult rats.	Hydrocarbons, Chlorinated	26-40	aldo-keto reductase family 1, member C12	Rattus norvegicus	183-193
6161768-3	1980	However, when the same bile specimens were pretreated with beta-glucuronidase before analysis by gas-liquid chromatography, large amounts of chlordecone alcohol appeared, accounting for 75% of total organochlorine compounds.	Hydrocarbons, Chlorinated	199-223	glucuronidase beta	Homo sapiens	59-77
6816679-0	1982	[Distribution of organochlorine pesticides and polychlorinated biphenyls among the elements of the Baltic Sea ecosystem].	Hydrocarbons, Chlorinated	17-31	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	106-109
857240-1	1977	Organochlorine insecticides and polychlorinated biphenyls (PCB"s were assessed in human blood and milk collected from Israeli mothers 2-4 days ater childbirth during 1975.	Hydrocarbons, Chlorinated	0-14	pyruvate carboxylase	Homo sapiens	59-62
7421984-2	1980	The special advantages of the capillary gas chromatography (separation of complex mixtures, simultaneous determination of by-components, improved reliability at the identification, increased sensitivity) can be used with right handling to directly separate the whole mixture of chlorohydrocarbons that are to be met in foods (insecticides, HCB and PCB).	Hydrocarbons, Chlorinated	278-296	pyruvate carboxylase	Homo sapiens	348-351
80916-5	1978	Recent attention has been concentrated on contamination of milk with organochlorine compounds such as DDT and PCB"s, that are found in many parts of the world.	Hydrocarbons, Chlorinated	69-83	pyruvate carboxylase	Homo sapiens	110-113
533308-4	1979	The results show very high contamination rates with organochlorine pesticides, especially with DDT.	Hydrocarbons, Chlorinated	52-66	D-dopachrome tautomerase	Homo sapiens	95-98
824867-10	1976	UDP-Glucuronosyltransferase was affected to a lesser extent than the microsomal mono-oxygenase or epoxide hydratase by chlorohydrocarbon treatment.	Hydrocarbons, Chlorinated	119-136	epoxide hydrolase 2	Rattus norvegicus	98-115
824930-0	1976	Chlorinated hydrocarbon residues (PCB and DDT) in human liver, adipose tissue and brain in Finland.	Hydrocarbons, Chlorinated	0-23	pyruvate carboxylase	Homo sapiens	34-37
1261832-0	1976	[Gas chromatographic method for determining organochlorine substances from the manufacture of nairite PNK in the air when present together].	Hydrocarbons, Chlorinated	44-58	polynucleotide kinase 3'-phosphatase	Homo sapiens	102-105
4501507-0	1972	Storage of organochlorine insecticides in people of Sao Paulo, Brazil.	Hydrocarbons, Chlorinated	11-25	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	52-55
4115899-0	1971	Effect of organochlorine insecticides on serum PBI level in occupationally exposed people.	Hydrocarbons, Chlorinated	10-24	submaxillary gland androgen regulated protein 3A	Homo sapiens	47-50
33440917-0	2021	Level of Organochlorine Pesticide in Prediabetic and Newly Diagnosed Diabetes Mellitus Patients with Varying Degree of Glucose Intolerance and Insulin Resistance among North Indian Population.	Hydrocarbons, Chlorinated	9-23	insulin	Homo sapiens	143-150
33791142-0	2021	Determination of Organochlorine Pesticides in Green Leafy Vegetable Samples via Fe3O4 Magnetic Nanoparticles Modified QuEChERS Integrated to Dispersive Liquid-Liquid Microextraction Coupled with Gas Chromatography-Mass Spectrometry.	Hydrocarbons, Chlorinated	17-31	gastrin	Homo sapiens	195-198
33160045-1	2021	BACKGROUND: Organochlorine pesticides such as DDT as well as postprandial hypertriglyceridemia have been linked with insulin resistance and diabetes mellitus.	Hydrocarbons, Chlorinated	12-26	insulin	Homo sapiens	117-124
32347927-1	2021	This work focuses on the development, validation and application of an analytical method for the determination of twenty organochlorine pesticides (OCPs) in human tissues using salting out liquid-liquid extraction (SALLE) and dispersive liquid-liquid microextraction (DLLME) for sample preparation and gas chromatography-mass spectrometry (GC-MS) to analyse the obtained extracts.	Hydrocarbons, Chlorinated	121-135	gastrin	Homo sapiens	302-305
33575062-0	2021	Compound-Specific Chlorine Isotope Analysis of Organochlorine Pesticides by Gas Chromatography-Negative Chemical Ionization Mass Spectrometry.	Hydrocarbons, Chlorinated	47-61	gastrin	Homo sapiens	76-79
33575062-3	2021	To overcome the mentioned problems, a novel method has been developed for the CSIA-Cl of eight organochlorine pesticides using gas chromatography-negative chemical ionization mass spectrometry (GC-NCI-qMS) in this study.	Hydrocarbons, Chlorinated	95-109	gastrin	Homo sapiens	127-130
33440917-1	2021	Background: Organochlorine pesticides (OCPs) exposure may induce an endocrine disruption which may lead to the risk of developing diabetes through alteration and disturbance of glucose metabolism, insulin resistance, and destruction of beta-cells.	Hydrocarbons, Chlorinated	12-26	insulin	Homo sapiens	197-204
32422283-0	2020	Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of alpha-synuclein-preformed fibril-induced toxicity and motor deficits.	Hydrocarbons, Chlorinated	30-44	synuclein, alpha	Mus musculus	101-116
32200152-1	2020	While contamination of indoor environment with organochlorine compounds (OCs) is well documented worldwide, only a few studies highlighted the problem of indoor pollution in Indian sub-continent, including Nepal.	Hydrocarbons, Chlorinated	47-71	amyloid beta precursor protein	Homo sapiens	10-11
32059314-2	2020	However, nitrate (NO3-), which is ubiquitous in groundwater, affects the mZVI-based attenuation of CAHs in a complicated manner.	Hydrocarbons, Chlorinated	99-103	NBL1, DAN family BMP antagonist	Homo sapiens	18-21
31677434-0	2020	Rapid changes in organochlorine pesticides in sediments from the East China sea and their response to human-induced catchment changes.	Hydrocarbons, Chlorinated	17-31	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	76-79
32549860-3	2020	Diabetogens, otherwise known as toxicants that cause insulin resistance in animal models and humans as a result of pancreatic beta-cell damage include the persistent organochlorine pesticides trans-nonachlor, oxychlordane, and DDE -the main metabolite of DDT, as well as another class of persistent organic pollutants, polychlorinated biphenyls (PCBs).	Hydrocarbons, Chlorinated	166-180	insulin	Homo sapiens	53-60
32108209-6	2020	The losses are more prominent in org-Cl hotspots of leaf litter, and both aliphatic and aromatic organochlorine compounds are lost from all samples at high Br- concentrations.	Hydrocarbons, Chlorinated	97-111	chromosome 12 open reading frame 73	Homo sapiens	156-158
31731000-0	2020	Gene-environment interactions between GSTs polymorphisms and targeted epigenetic alterations in hepatocellular carcinoma following organochlorine pesticides (OCPs) exposure.	Hydrocarbons, Chlorinated	131-145	glutathione S-transferase mu 1	Homo sapiens	38-42
31542660-0	2019	The organochlorine pesticides pentachlorophenol and dichlorodiphenyltrichloroethane increase secretion and production of interleukin 6 by human immune cells.	Hydrocarbons, Chlorinated	4-18	interleukin 6	Homo sapiens	121-134
31726361-9	2020	Each standard deviation increase in PC 1 (organochlorine pesticides, some phenols) and PC 6 (cadmium, bisphenol A) was associated with 0.2 cm (95% CI: -0.4, 0.0) and 0.1 cm (95% CI: -0.4, 0.1) lower birth length, respectively.	Hydrocarbons, Chlorinated	42-56	proprotein convertase subtilisin/kexin type 1	Homo sapiens	36-40
31661968-0	2019	Impacts of Seasonal Variation on Organochlorine Pesticides in the East China Sea and Northern South China Sea.	Hydrocarbons, Chlorinated	33-47	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	11-14
31661968-0	2019	Impacts of Seasonal Variation on Organochlorine Pesticides in the East China Sea and Northern South China Sea.	Hydrocarbons, Chlorinated	33-47	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	77-80
31062993-1	2019	The detection of chlorinated hydrocarbons by Curiosity on Mars has been attributed to the presence of unidentified indigenous organic matter.	Hydrocarbons, Chlorinated	17-41	methionyl-tRNA synthetase 1	Homo sapiens	58-62