PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 33535497-4 2021 In this study, we investigated the antibacterial and anti-inflammatory properties of surfactin-loaded kappa-carrageenan oligosaccharides linked cellulose nanofibers (CO-CNF) nanoparticles. surfactin peptide 85-94 NPHS1 adhesion molecule, nephrin Homo sapiens 169-172 33535497-9 2021 Furthermore, anti-inflammatory effects of surfactin-loaded CO-CNF nanoparticles was observed in lipopolysaccharide (LPS)-stimulated human gingival fibroblast (HGF) cells. surfactin peptide 42-51 NPHS1 adhesion molecule, nephrin Homo sapiens 62-65 33535497-9 2021 Furthermore, anti-inflammatory effects of surfactin-loaded CO-CNF nanoparticles was observed in lipopolysaccharide (LPS)-stimulated human gingival fibroblast (HGF) cells. surfactin peptide 42-51 hepatocyte growth factor Homo sapiens 159-162 31027820-4 2019 The main families of metabolites in the LPF were iturin A, fengycin and surfactin with maximum concentrations of 407, 853 and 658 mug mL-1, respectively. surfactin peptide 72-81 L1 cell adhesion molecule Mus musculus 134-138 32922544-6 2020 Surfactin suppressed PM-promoted cell migration and invasion and colony formation of SCC4 and SCC25 human oral squamous cell carcinoma cell lines. surfactin peptide 0-9 MAU2 sister chromatid cohesion factor Homo sapiens 85-89 32922544-7 2020 We observed that PM induced MMP-2 and MMP-9 expression, which was inhibited by surfactin. surfactin peptide 79-88 matrix metallopeptidase 2 Homo sapiens 28-33 32922544-7 2020 We observed that PM induced MMP-2 and MMP-9 expression, which was inhibited by surfactin. surfactin peptide 79-88 matrix metallopeptidase 9 Homo sapiens 38-43 32922544-9 2020 Moreover, surfactin could reduce Akt, mTOR, p65, and c-Jun activation and IL-6 secretion induced by PM. surfactin peptide 10-19 AKT serine/threonine kinase 1 Homo sapiens 33-36 32922544-9 2020 Moreover, surfactin could reduce Akt, mTOR, p65, and c-Jun activation and IL-6 secretion induced by PM. surfactin peptide 10-19 mechanistic target of rapamycin kinase Homo sapiens 38-42 32922544-9 2020 Moreover, surfactin could reduce Akt, mTOR, p65, and c-Jun activation and IL-6 secretion induced by PM. surfactin peptide 10-19 RELA proto-oncogene, NF-kB subunit Homo sapiens 44-47 32922544-9 2020 Moreover, surfactin could reduce Akt, mTOR, p65, and c-Jun activation and IL-6 secretion induced by PM. surfactin peptide 10-19 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 53-58 32922544-9 2020 Moreover, surfactin could reduce Akt, mTOR, p65, and c-Jun activation and IL-6 secretion induced by PM. surfactin peptide 10-19 interleukin 6 Homo sapiens 74-78 32922544-11 2020 Taken together, these results suggest that surfactin functions as a suppressor of PM-induced MMP2/9-dependent oral cancer cell migration and invasion by inhibiting the activation of phosphoinositide 3-kinase (PI3K)/Akt/mTOR and PI3K/Akt/nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1)/IL-6 signaling pathways. surfactin peptide 43-52 matrix metallopeptidase 2 Homo sapiens 93-99 32922544-11 2020 Taken together, these results suggest that surfactin functions as a suppressor of PM-induced MMP2/9-dependent oral cancer cell migration and invasion by inhibiting the activation of phosphoinositide 3-kinase (PI3K)/Akt/mTOR and PI3K/Akt/nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1)/IL-6 signaling pathways. surfactin peptide 43-52 phosphoinositide-3-kinase regulatory subunit 1 Homo sapiens 182-207 32922544-11 2020 Taken together, these results suggest that surfactin functions as a suppressor of PM-induced MMP2/9-dependent oral cancer cell migration and invasion by inhibiting the activation of phosphoinositide 3-kinase (PI3K)/Akt/mTOR and PI3K/Akt/nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1)/IL-6 signaling pathways. surfactin peptide 43-52 AKT serine/threonine kinase 1 Homo sapiens 215-218 32922544-11 2020 Taken together, these results suggest that surfactin functions as a suppressor of PM-induced MMP2/9-dependent oral cancer cell migration and invasion by inhibiting the activation of phosphoinositide 3-kinase (PI3K)/Akt/mTOR and PI3K/Akt/nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1)/IL-6 signaling pathways. surfactin peptide 43-52 mechanistic target of rapamycin kinase Homo sapiens 219-223 32922544-11 2020 Taken together, these results suggest that surfactin functions as a suppressor of PM-induced MMP2/9-dependent oral cancer cell migration and invasion by inhibiting the activation of phosphoinositide 3-kinase (PI3K)/Akt/mTOR and PI3K/Akt/nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1)/IL-6 signaling pathways. surfactin peptide 43-52 AKT serine/threonine kinase 1 Homo sapiens 233-236 32922544-11 2020 Taken together, these results suggest that surfactin functions as a suppressor of PM-induced MMP2/9-dependent oral cancer cell migration and invasion by inhibiting the activation of phosphoinositide 3-kinase (PI3K)/Akt/mTOR and PI3K/Akt/nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1)/IL-6 signaling pathways. surfactin peptide 43-52 nuclear factor kappa B subunit 1 Homo sapiens 260-269 32922544-11 2020 Taken together, these results suggest that surfactin functions as a suppressor of PM-induced MMP2/9-dependent oral cancer cell migration and invasion by inhibiting the activation of phosphoinositide 3-kinase (PI3K)/Akt/mTOR and PI3K/Akt/nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1)/IL-6 signaling pathways. surfactin peptide 43-52 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 275-294 32922544-11 2020 Taken together, these results suggest that surfactin functions as a suppressor of PM-induced MMP2/9-dependent oral cancer cell migration and invasion by inhibiting the activation of phosphoinositide 3-kinase (PI3K)/Akt/mTOR and PI3K/Akt/nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1)/IL-6 signaling pathways. surfactin peptide 43-52 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 296-300 32922544-11 2020 Taken together, these results suggest that surfactin functions as a suppressor of PM-induced MMP2/9-dependent oral cancer cell migration and invasion by inhibiting the activation of phosphoinositide 3-kinase (PI3K)/Akt/mTOR and PI3K/Akt/nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1)/IL-6 signaling pathways. surfactin peptide 43-52 interleukin 6 Homo sapiens 302-306 32172322-2 2020 Bacillus subtilis 168 was genetically modified to produce surfactin by increasing the supply of the precursor fatty acyl-CoA by overexpressing 4" phosphopantetheinyl transferase, medium-chain acyl-acyl carrier protein (ACP) thioesterase and fatty acyl CoA ligase (encoded by sfp, bte, and yhfL, respectively), and knocking out acyl-CoA dehydrogenase (encoded by fadE). surfactin peptide 58-67 long-chain fatty-acid-CoA ligase (degradative) Bacillus subtilis subsp. subtilis str. 168 289-293 32172322-2 2020 Bacillus subtilis 168 was genetically modified to produce surfactin by increasing the supply of the precursor fatty acyl-CoA by overexpressing 4" phosphopantetheinyl transferase, medium-chain acyl-acyl carrier protein (ACP) thioesterase and fatty acyl CoA ligase (encoded by sfp, bte, and yhfL, respectively), and knocking out acyl-CoA dehydrogenase (encoded by fadE). surfactin peptide 58-67 acyl-CoA dehydrogenase (FAD dependent) Bacillus subtilis subsp. subtilis str. 168 362-366 33535497-11 2021 Collectively, these observations supported the use of surfactin-loaded CO-CNF as a potential candidate for periodontitis management. surfactin peptide 54-63 NPHS1 adhesion molecule, nephrin Homo sapiens 74-77 33193889-6 2020 Surfactin-induced apoptosis was associated with caspase activation and poly(ADP-ribose) polymerase (PARP) cleavage and was regulated by the mitochondrial pathway, exemplified by mitochondrial depolarization, mitochondrial-derived reactive oxidative species (ROS) production, cytochrome c release, up-regulation of Bad and Bax, and down-regulation of Bcl-2. surfactin peptide 0-9 poly(ADP-ribose) polymerase 1 Homo sapiens 71-98 33193889-6 2020 Surfactin-induced apoptosis was associated with caspase activation and poly(ADP-ribose) polymerase (PARP) cleavage and was regulated by the mitochondrial pathway, exemplified by mitochondrial depolarization, mitochondrial-derived reactive oxidative species (ROS) production, cytochrome c release, up-regulation of Bad and Bax, and down-regulation of Bcl-2. surfactin peptide 0-9 poly(ADP-ribose) polymerase 1 Homo sapiens 100-104 33193889-6 2020 Surfactin-induced apoptosis was associated with caspase activation and poly(ADP-ribose) polymerase (PARP) cleavage and was regulated by the mitochondrial pathway, exemplified by mitochondrial depolarization, mitochondrial-derived reactive oxidative species (ROS) production, cytochrome c release, up-regulation of Bad and Bax, and down-regulation of Bcl-2. surfactin peptide 0-9 cytochrome c, somatic Homo sapiens 275-287 33193889-6 2020 Surfactin-induced apoptosis was associated with caspase activation and poly(ADP-ribose) polymerase (PARP) cleavage and was regulated by the mitochondrial pathway, exemplified by mitochondrial depolarization, mitochondrial-derived reactive oxidative species (ROS) production, cytochrome c release, up-regulation of Bad and Bax, and down-regulation of Bcl-2. surfactin peptide 0-9 BCL2 associated X, apoptosis regulator Homo sapiens 322-325 33193889-6 2020 Surfactin-induced apoptosis was associated with caspase activation and poly(ADP-ribose) polymerase (PARP) cleavage and was regulated by the mitochondrial pathway, exemplified by mitochondrial depolarization, mitochondrial-derived reactive oxidative species (ROS) production, cytochrome c release, up-regulation of Bad and Bax, and down-regulation of Bcl-2. surfactin peptide 0-9 BCL2 apoptosis regulator Homo sapiens 350-355 33193889-8 2020 Surfactin-induced mitochondrial-derived ROS generation was associated with JNK1/2 activation. surfactin peptide 0-9 mitogen-activated protein kinase 8 Homo sapiens 75-81 33193889-9 2020 After treatment with surfactin, ROS caused JNK1/2-dependent cell death of SCC4 and SCC25 cells. surfactin peptide 21-30 mitogen-activated protein kinase 8 Homo sapiens 43-49 29226733-0 2018 Enteric-coated insulin microparticles delivered by lipopeptides of iturin and surfactin. surfactin peptide 78-87 insulin Homo sapiens 15-22 30973929-5 2019 Compared with surfactin, one of the analogues we developed, SLP5, has lower hemolytic activity, with the same antiviral activity. surfactin peptide 14-23 synaptotagmin like 5 Homo sapiens 60-64 30973929-6 2019 The selectivity index of SLP5 is 52, while the SI for surfactin is 4, in other words, the safe and effective concentration range of SLP5 is 12 times greater than that of surfactin. surfactin peptide 54-63 synaptotagmin like 5 Homo sapiens 132-136 30973929-9 2019 Surfactin derivatives similar to SLP5 could be obtained by lactone bond hydrolyzation of surfactin, as well as total synthesis. surfactin peptide 0-9 synaptotagmin like 5 Homo sapiens 33-37 30973929-9 2019 Surfactin derivatives similar to SLP5 could be obtained by lactone bond hydrolyzation of surfactin, as well as total synthesis. surfactin peptide 89-98 synaptotagmin like 5 Homo sapiens 33-37 30453038-4 2019 First, we restored surfactin biosynthetic activity by integrating a complete sfp gene into the nonproducing Bacillus subtilis 168 strain and obtained a surfactin titer of 0.4 g/l. surfactin peptide 19-28 sfp Bacillus subtilis subsp. subtilis str. 168 77-80 29226733-1 2018 Surfactin, a lipopeptide produced by Bacillus species, has been used for the oral delivery of insulin. surfactin peptide 0-9 insulin Homo sapiens 94-101 29226733-7 2018 For further improving oral hypoglycemic effect, surfactin was added to form the spherical enteric-coated insulin microparticles in a formulation containing insulin, Acryl-Eze, iturin and surfactin at a ratio of 1:1:0.5: 0.5 (w/w), with an insulin encapsulation efficiency of 66.22%. surfactin peptide 48-57 insulin Homo sapiens 105-112 29226733-7 2018 For further improving oral hypoglycemic effect, surfactin was added to form the spherical enteric-coated insulin microparticles in a formulation containing insulin, Acryl-Eze, iturin and surfactin at a ratio of 1:1:0.5: 0.5 (w/w), with an insulin encapsulation efficiency of 66.22%. surfactin peptide 48-57 insulin Homo sapiens 156-163 29226733-7 2018 For further improving oral hypoglycemic effect, surfactin was added to form the spherical enteric-coated insulin microparticles in a formulation containing insulin, Acryl-Eze, iturin and surfactin at a ratio of 1:1:0.5: 0.5 (w/w), with an insulin encapsulation efficiency of 66.22%. surfactin peptide 48-57 insulin Homo sapiens 156-163 29226733-8 2018 The enteric-coated insulin microparticles delivered by iturin plus surfactin showed a classical profile for controlled release in the intestine with a relative bioavailability of 7.67% after oral administration, which could effectively control the postprandial blood glucose at a level about 50% of the initial one just like the subcutaneous injection. surfactin peptide 67-76 insulin Homo sapiens 19-26 29226733-9 2018 Collectively, iturin plus surfactin is more efficient for oral delivering insulin than the sole one, and the resultant enteric-coated insulin microparticles are potential for the development of oral insulin to control postprandial blood glucose in diabetic patients. surfactin peptide 26-35 insulin Homo sapiens 74-81 25044846-7 2014 The addition of 1 muM surfactin to the DESI spray solvent significantly improved the results for negative and positive ion modes. surfactin peptide 22-31 latexin Homo sapiens 18-21 29606866-3 2018 Surfactin (SUR), a cyclic lipopeptide biosurfactant, has been found to display anticancer activity. surfactin peptide 0-9 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 Mus musculus 11-14 28302403-4 2017 We further chemically synthesized surfactin variant by replacing its fatty acid chain (C15) with a shortened one (C14), and found this replacement did not influence its ability to orally deliver insulin. surfactin peptide 34-43 placenta-specific 8 Mus musculus 87-90 27082998-0 2016 Bacillus-produced surfactin attenuates chronic inflammation in atherosclerotic lesions of ApoE(-/-) mice. surfactin peptide 18-27 apolipoprotein E Mus musculus 90-94 27082998-4 2016 The results showed surfactin could induce anti-inflammatory factors such as IgA, transforming growth factor (TGF)-beta and interleukin (IL)-10 in the intestine. surfactin peptide 19-28 interleukin 10 Mus musculus 123-142 27082998-5 2016 Further investigation discovered that surfactin also systemically induced CD4(+)CD25(+)FoxP3(+) Tregs in spleen, which could inhibit T cells to produce pro-inflammatory cytokines such as tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma. surfactin peptide 38-47 tumor necrosis factor Mus musculus 187-220 27082998-5 2016 Further investigation discovered that surfactin also systemically induced CD4(+)CD25(+)FoxP3(+) Tregs in spleen, which could inhibit T cells to produce pro-inflammatory cytokines such as tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma. surfactin peptide 38-47 interferon gamma Mus musculus 225-247 27082998-6 2016 The IgG subclass pattern with high titer of IgG1 (Th2-type) but low titer of IgG2a (Th1-type) was also found in the surfactin-treated mice. surfactin peptide 116-125 immunoglobulin heavy constant gamma 1 (G1m marker) Mus musculus 44-48 27082998-6 2016 The IgG subclass pattern with high titer of IgG1 (Th2-type) but low titer of IgG2a (Th1-type) was also found in the surfactin-treated mice. surfactin peptide 116-125 immunoglobulin heavy variable V1-9 Mus musculus 77-82 27082998-6 2016 The IgG subclass pattern with high titer of IgG1 (Th2-type) but low titer of IgG2a (Th1-type) was also found in the surfactin-treated mice. surfactin peptide 116-125 negative elongation factor complex member C/D, Th1l Mus musculus 84-87 27082998-7 2016 As a result, the attenuation of chronic inflammation was observed in the surfactin-treated groups accompanying with less TNF-alpha but more IL-10 in the atherosclerotic lesions. surfactin peptide 73-82 tumor necrosis factor Mus musculus 121-130 27082998-7 2016 As a result, the attenuation of chronic inflammation was observed in the surfactin-treated groups accompanying with less TNF-alpha but more IL-10 in the atherosclerotic lesions. surfactin peptide 73-82 interleukin 10 Mus musculus 140-145 27082998-9 2016 Collectively, surfactin could significantly attenuate atherosclerotic lesions on the aorta by restoration of the delicate balance of Th1/Th2 response in mice. surfactin peptide 14-23 negative elongation factor complex member C/D, Th1l Mus musculus 133-136 25921807-4 2015 Expression of rapQ in B. subtilis OKB105 strongly suppressed its sporulation efficiency, transformation efficiency, and surfactin production. surfactin peptide 120-129 RapQ Bacillus amyloliquefaciens 14-18 25921807-6 2015 We also found that expression of rapQ decreased the transcriptional level of the sporulation-related gene spoIIE and surfactin synthesis-related gene srfA; meanwhile, the transcriptional levels of these genes could be rescued by co-expression of phrQ and in vitro addition of PhrQ pentapeptide. surfactin peptide 117-126 RapQ Bacillus amyloliquefaciens 33-37 25921807-8 2015 These results indicate that this new plasmid-born RapQ-PhrQ system controls sporulation, competent cell formation, and surfactin production in B. subtilis OKB105. surfactin peptide 119-128 RapQ Bacillus amyloliquefaciens 50-54 27534429-6 2016 Moreover, surfactin also induced DCs to release IL-6 and TNF-alpha, indicating that DCs were functionally mature. surfactin peptide 10-19 interleukin 6 Homo sapiens 48-52 27534429-6 2016 Moreover, surfactin also induced DCs to release IL-6 and TNF-alpha, indicating that DCs were functionally mature. surfactin peptide 10-19 tumor necrosis factor Homo sapiens 57-66 27534429-7 2016 In addition, the IkappaB-alpha level in surfactin-treated DCs was significantly reduced while the nuclear p65 level was notably increased, preliminarily indicating that nuclear factor-kappa B (NF-kappaB) signaling pathway might play an important role in surfactin-induced DCs maturation. surfactin peptide 40-49 NFKB inhibitor alpha Homo sapiens 17-30 27534429-7 2016 In addition, the IkappaB-alpha level in surfactin-treated DCs was significantly reduced while the nuclear p65 level was notably increased, preliminarily indicating that nuclear factor-kappa B (NF-kappaB) signaling pathway might play an important role in surfactin-induced DCs maturation. surfactin peptide 40-49 nuclear factor kappa B subunit 1 Homo sapiens 169-191 27534429-7 2016 In addition, the IkappaB-alpha level in surfactin-treated DCs was significantly reduced while the nuclear p65 level was notably increased, preliminarily indicating that nuclear factor-kappa B (NF-kappaB) signaling pathway might play an important role in surfactin-induced DCs maturation. surfactin peptide 40-49 nuclear factor kappa B subunit 1 Homo sapiens 193-202 27534429-7 2016 In addition, the IkappaB-alpha level in surfactin-treated DCs was significantly reduced while the nuclear p65 level was notably increased, preliminarily indicating that nuclear factor-kappa B (NF-kappaB) signaling pathway might play an important role in surfactin-induced DCs maturation. surfactin peptide 254-263 RELA proto-oncogene, NF-kB subunit Homo sapiens 106-109 27534429-7 2016 In addition, the IkappaB-alpha level in surfactin-treated DCs was significantly reduced while the nuclear p65 level was notably increased, preliminarily indicating that nuclear factor-kappa B (NF-kappaB) signaling pathway might play an important role in surfactin-induced DCs maturation. surfactin peptide 254-263 nuclear factor kappa B subunit 1 Homo sapiens 169-191 27534429-7 2016 In addition, the IkappaB-alpha level in surfactin-treated DCs was significantly reduced while the nuclear p65 level was notably increased, preliminarily indicating that nuclear factor-kappa B (NF-kappaB) signaling pathway might play an important role in surfactin-induced DCs maturation. surfactin peptide 254-263 nuclear factor kappa B subunit 1 Homo sapiens 193-202 26347324-4 2015 Electrospray mass spectrometry analysis showed that these strains produced heterogeneous mixture of antibiotics belonging to fengycin and surfactin for BL1 and BT5, to iturin and surfactin for BR8, to bacillomycin D, fengycin and surfactin for BF11. surfactin peptide 138-147 BEL1-like homeodomain protein 11 Solanum lycopersicum 152-155 23906708-2 2013 In this study, we investigated the effects of surfactin, a surfactant from Bacillus subtilis, on oligomeric amyloid beta (Abeta)-induced microglial activation and neurotoxicity. surfactin peptide 46-55 amyloid beta (A4) precursor protein Mus musculus 122-127 23906708-3 2013 Surfactin significantly suppressed expression of MMP-9, iNOS and COX-2, as well as production of ROS, NO, PGE2, TNF-alpha, IL-1beta, IL-6 and MCP-1 in Abeta-stimulated BV-2 microglial cells. surfactin peptide 0-9 matrix metallopeptidase 9 Mus musculus 49-54 23906708-3 2013 Surfactin significantly suppressed expression of MMP-9, iNOS and COX-2, as well as production of ROS, NO, PGE2, TNF-alpha, IL-1beta, IL-6 and MCP-1 in Abeta-stimulated BV-2 microglial cells. surfactin peptide 0-9 nitric oxide synthase 2, inducible Mus musculus 56-60 23906708-3 2013 Surfactin significantly suppressed expression of MMP-9, iNOS and COX-2, as well as production of ROS, NO, PGE2, TNF-alpha, IL-1beta, IL-6 and MCP-1 in Abeta-stimulated BV-2 microglial cells. surfactin peptide 0-9 cytochrome c oxidase II, mitochondrial Mus musculus 65-70 23906708-3 2013 Surfactin significantly suppressed expression of MMP-9, iNOS and COX-2, as well as production of ROS, NO, PGE2, TNF-alpha, IL-1beta, IL-6 and MCP-1 in Abeta-stimulated BV-2 microglial cells. surfactin peptide 0-9 tumor necrosis factor Mus musculus 112-121 23906708-3 2013 Surfactin significantly suppressed expression of MMP-9, iNOS and COX-2, as well as production of ROS, NO, PGE2, TNF-alpha, IL-1beta, IL-6 and MCP-1 in Abeta-stimulated BV-2 microglial cells. surfactin peptide 0-9 interleukin 1 beta Mus musculus 123-131 23906708-3 2013 Surfactin significantly suppressed expression of MMP-9, iNOS and COX-2, as well as production of ROS, NO, PGE2, TNF-alpha, IL-1beta, IL-6 and MCP-1 in Abeta-stimulated BV-2 microglial cells. surfactin peptide 0-9 interleukin 6 Mus musculus 133-137 23906708-3 2013 Surfactin significantly suppressed expression of MMP-9, iNOS and COX-2, as well as production of ROS, NO, PGE2, TNF-alpha, IL-1beta, IL-6 and MCP-1 in Abeta-stimulated BV-2 microglial cells. surfactin peptide 0-9 mast cell protease 1 Mus musculus 142-147 23906708-3 2013 Surfactin significantly suppressed expression of MMP-9, iNOS and COX-2, as well as production of ROS, NO, PGE2, TNF-alpha, IL-1beta, IL-6 and MCP-1 in Abeta-stimulated BV-2 microglial cells. surfactin peptide 0-9 amyloid beta (A4) precursor protein Mus musculus 151-156 23906708-4 2013 Moreover, surfactin markedly inhibited Abeta-induced nuclear translocation and activation of NF-kappaB as well as phosphorylation of JNK and p38 MAPK. surfactin peptide 10-19 amyloid beta (A4) precursor protein Mus musculus 39-44 23906708-4 2013 Moreover, surfactin markedly inhibited Abeta-induced nuclear translocation and activation of NF-kappaB as well as phosphorylation of JNK and p38 MAPK. surfactin peptide 10-19 mitogen-activated protein kinase 14 Mus musculus 141-149 23906708-5 2013 Furthermore, surfactin protected hippocampal HT22 cells from indirect neuronal toxicity mediated by Abeta-treated microglial cells, but had no effect on Abeta-induced direct toxicity to HT22 cells. surfactin peptide 13-22 amyloid beta (A4) precursor protein Mus musculus 100-105 23906708-6 2013 These results suggest that surfactin impairs the Abeta-induced inflammatory response of microglial cells and confers protection against indirect neurotoxicity to hippocampal cells. surfactin peptide 27-36 amyloid beta (A4) precursor protein Mus musculus 49-54 25151823-13 2013 In non-infectious conditions, both surfactin and mycosubtilin induced the expression of two peroxidase encoding genes (POX2, POX381), however, the expression of LOX (lipoxygenase), AOS (allene oxide synthase) genes involved in the octadecanoid pathway, as well as of the pathogenesis-related genes PR1 was only induced by mycosubtilin. surfactin peptide 35-44 peroxidase-like Triticum aestivum 119-123 23360889-0 2013 Involvement of PKA and HO-1 signaling in anti-inflammatory effects of surfactin in BV-2 microglial cells. surfactin peptide 70-79 heme oxygenase 1 Mus musculus 23-27 23360889-3 2013 Surfactin significantly inhibited excessive production of the pro-inflammatory mediators TNF-alpha, IL-1beta, IL-6, monocyte chemoattractant protein-1 (MCP-1), prostaglandin E2 (PGE2), nitric oxide (NO) and reactive oxygen species (ROS), and suppressed the expression of matrix metalloproteinase-9 (MMP-9), inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2). surfactin peptide 0-9 tumor necrosis factor Mus musculus 89-98 23360889-3 2013 Surfactin significantly inhibited excessive production of the pro-inflammatory mediators TNF-alpha, IL-1beta, IL-6, monocyte chemoattractant protein-1 (MCP-1), prostaglandin E2 (PGE2), nitric oxide (NO) and reactive oxygen species (ROS), and suppressed the expression of matrix metalloproteinase-9 (MMP-9), inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2). surfactin peptide 0-9 interleukin 1 beta Mus musculus 100-108 23360889-3 2013 Surfactin significantly inhibited excessive production of the pro-inflammatory mediators TNF-alpha, IL-1beta, IL-6, monocyte chemoattractant protein-1 (MCP-1), prostaglandin E2 (PGE2), nitric oxide (NO) and reactive oxygen species (ROS), and suppressed the expression of matrix metalloproteinase-9 (MMP-9), inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2). surfactin peptide 0-9 interleukin 6 Mus musculus 110-114 23360889-3 2013 Surfactin significantly inhibited excessive production of the pro-inflammatory mediators TNF-alpha, IL-1beta, IL-6, monocyte chemoattractant protein-1 (MCP-1), prostaglandin E2 (PGE2), nitric oxide (NO) and reactive oxygen species (ROS), and suppressed the expression of matrix metalloproteinase-9 (MMP-9), inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2). surfactin peptide 0-9 chemokine (C-C motif) ligand 2 Mus musculus 116-150 23360889-3 2013 Surfactin significantly inhibited excessive production of the pro-inflammatory mediators TNF-alpha, IL-1beta, IL-6, monocyte chemoattractant protein-1 (MCP-1), prostaglandin E2 (PGE2), nitric oxide (NO) and reactive oxygen species (ROS), and suppressed the expression of matrix metalloproteinase-9 (MMP-9), inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2). surfactin peptide 0-9 chemokine (C-C motif) ligand 2 Mus musculus 152-157 23360889-3 2013 Surfactin significantly inhibited excessive production of the pro-inflammatory mediators TNF-alpha, IL-1beta, IL-6, monocyte chemoattractant protein-1 (MCP-1), prostaglandin E2 (PGE2), nitric oxide (NO) and reactive oxygen species (ROS), and suppressed the expression of matrix metalloproteinase-9 (MMP-9), inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2). surfactin peptide 0-9 matrix metallopeptidase 9 Mus musculus 271-297 23360889-3 2013 Surfactin significantly inhibited excessive production of the pro-inflammatory mediators TNF-alpha, IL-1beta, IL-6, monocyte chemoattractant protein-1 (MCP-1), prostaglandin E2 (PGE2), nitric oxide (NO) and reactive oxygen species (ROS), and suppressed the expression of matrix metalloproteinase-9 (MMP-9), inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2). surfactin peptide 0-9 matrix metallopeptidase 9 Mus musculus 299-304 23360889-3 2013 Surfactin significantly inhibited excessive production of the pro-inflammatory mediators TNF-alpha, IL-1beta, IL-6, monocyte chemoattractant protein-1 (MCP-1), prostaglandin E2 (PGE2), nitric oxide (NO) and reactive oxygen species (ROS), and suppressed the expression of matrix metalloproteinase-9 (MMP-9), inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2). surfactin peptide 0-9 nitric oxide synthase 2, inducible Mus musculus 307-328 23360889-3 2013 Surfactin significantly inhibited excessive production of the pro-inflammatory mediators TNF-alpha, IL-1beta, IL-6, monocyte chemoattractant protein-1 (MCP-1), prostaglandin E2 (PGE2), nitric oxide (NO) and reactive oxygen species (ROS), and suppressed the expression of matrix metalloproteinase-9 (MMP-9), inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2). surfactin peptide 0-9 nitric oxide synthase 2, inducible Mus musculus 330-334 23360889-3 2013 Surfactin significantly inhibited excessive production of the pro-inflammatory mediators TNF-alpha, IL-1beta, IL-6, monocyte chemoattractant protein-1 (MCP-1), prostaglandin E2 (PGE2), nitric oxide (NO) and reactive oxygen species (ROS), and suppressed the expression of matrix metalloproteinase-9 (MMP-9), inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2). surfactin peptide 0-9 prostaglandin-endoperoxide synthase 2 Mus musculus 340-356 23360889-3 2013 Surfactin significantly inhibited excessive production of the pro-inflammatory mediators TNF-alpha, IL-1beta, IL-6, monocyte chemoattractant protein-1 (MCP-1), prostaglandin E2 (PGE2), nitric oxide (NO) and reactive oxygen species (ROS), and suppressed the expression of matrix metalloproteinase-9 (MMP-9), inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2). surfactin peptide 0-9 prostaglandin-endoperoxide synthase 2 Mus musculus 358-363 23360889-4 2013 Subsequent mechanistic studies revealed that surfactin inhibited LTA-induced nuclear factor-kappaB (NF-kappaB) and signal transducer and activator of transcription-1 (STAT-1) activation. surfactin peptide 45-54 signal transducer and activator of transcription 1 Mus musculus 115-165 23360889-4 2013 Subsequent mechanistic studies revealed that surfactin inhibited LTA-induced nuclear factor-kappaB (NF-kappaB) and signal transducer and activator of transcription-1 (STAT-1) activation. surfactin peptide 45-54 signal transducer and activator of transcription 1 Mus musculus 167-173 23360889-5 2013 However, surfactin increases the phosphorylation of the STAT-3, a component of the homeostatic mechanism causing anti-inflammatory events. surfactin peptide 9-18 signal transducer and activator of transcription 3 Mus musculus 56-62 23360889-6 2013 We also demonstrated that surfactin induces heme oxygenase-1 (HO-1) expression and nuclear factor-regulated factor-2 (Nrf-2) activation, and that the anti-inflammatory effects of surfactin are abrogated by small interfering RNA-mediated knock-down of HO-1 or Nrf-2. surfactin peptide 26-35 heme oxygenase 1 Mus musculus 44-60 23360889-6 2013 We also demonstrated that surfactin induces heme oxygenase-1 (HO-1) expression and nuclear factor-regulated factor-2 (Nrf-2) activation, and that the anti-inflammatory effects of surfactin are abrogated by small interfering RNA-mediated knock-down of HO-1 or Nrf-2. surfactin peptide 26-35 heme oxygenase 1 Mus musculus 62-66 23360889-6 2013 We also demonstrated that surfactin induces heme oxygenase-1 (HO-1) expression and nuclear factor-regulated factor-2 (Nrf-2) activation, and that the anti-inflammatory effects of surfactin are abrogated by small interfering RNA-mediated knock-down of HO-1 or Nrf-2. surfactin peptide 26-35 nuclear factor, erythroid derived 2, like 2 Mus musculus 83-116 23360889-6 2013 We also demonstrated that surfactin induces heme oxygenase-1 (HO-1) expression and nuclear factor-regulated factor-2 (Nrf-2) activation, and that the anti-inflammatory effects of surfactin are abrogated by small interfering RNA-mediated knock-down of HO-1 or Nrf-2. surfactin peptide 26-35 nuclear factor, erythroid derived 2, like 2 Mus musculus 118-123 23360889-6 2013 We also demonstrated that surfactin induces heme oxygenase-1 (HO-1) expression and nuclear factor-regulated factor-2 (Nrf-2) activation, and that the anti-inflammatory effects of surfactin are abrogated by small interfering RNA-mediated knock-down of HO-1 or Nrf-2. surfactin peptide 26-35 heme oxygenase 1 Mus musculus 251-255 23360889-6 2013 We also demonstrated that surfactin induces heme oxygenase-1 (HO-1) expression and nuclear factor-regulated factor-2 (Nrf-2) activation, and that the anti-inflammatory effects of surfactin are abrogated by small interfering RNA-mediated knock-down of HO-1 or Nrf-2. surfactin peptide 26-35 nuclear factor, erythroid derived 2, like 2 Mus musculus 259-264 23360889-6 2013 We also demonstrated that surfactin induces heme oxygenase-1 (HO-1) expression and nuclear factor-regulated factor-2 (Nrf-2) activation, and that the anti-inflammatory effects of surfactin are abrogated by small interfering RNA-mediated knock-down of HO-1 or Nrf-2. surfactin peptide 179-188 heme oxygenase 1 Mus musculus 62-66 23360889-6 2013 We also demonstrated that surfactin induces heme oxygenase-1 (HO-1) expression and nuclear factor-regulated factor-2 (Nrf-2) activation, and that the anti-inflammatory effects of surfactin are abrogated by small interfering RNA-mediated knock-down of HO-1 or Nrf-2. surfactin peptide 179-188 nuclear factor, erythroid derived 2, like 2 Mus musculus 83-116 23360889-6 2013 We also demonstrated that surfactin induces heme oxygenase-1 (HO-1) expression and nuclear factor-regulated factor-2 (Nrf-2) activation, and that the anti-inflammatory effects of surfactin are abrogated by small interfering RNA-mediated knock-down of HO-1 or Nrf-2. surfactin peptide 179-188 nuclear factor, erythroid derived 2, like 2 Mus musculus 118-123 23360889-6 2013 We also demonstrated that surfactin induces heme oxygenase-1 (HO-1) expression and nuclear factor-regulated factor-2 (Nrf-2) activation, and that the anti-inflammatory effects of surfactin are abrogated by small interfering RNA-mediated knock-down of HO-1 or Nrf-2. surfactin peptide 179-188 heme oxygenase 1 Mus musculus 251-255 23360889-6 2013 We also demonstrated that surfactin induces heme oxygenase-1 (HO-1) expression and nuclear factor-regulated factor-2 (Nrf-2) activation, and that the anti-inflammatory effects of surfactin are abrogated by small interfering RNA-mediated knock-down of HO-1 or Nrf-2. surfactin peptide 179-188 nuclear factor, erythroid derived 2, like 2 Mus musculus 259-264 23360889-7 2013 Interestingly, we found that surfactin increased the level of cAMP and induced phosphorylation of cAMP responsive element binding protein (CREB) in microglial cells. surfactin peptide 29-38 cAMP responsive element binding protein 1 Mus musculus 98-137 23360889-7 2013 Interestingly, we found that surfactin increased the level of cAMP and induced phosphorylation of cAMP responsive element binding protein (CREB) in microglial cells. surfactin peptide 29-38 cAMP responsive element binding protein 1 Mus musculus 139-143 23360889-8 2013 Furthermore, treatment with the protein kinase A (PKA) inhibitor, H-89, blocked HO-1 induction by surfactin and abolished surfactin"s suppressive effects on ROS and NO production. surfactin peptide 98-107 heme oxygenase 1 Mus musculus 80-84 23360889-9 2013 These results indicate that HO-1 and its upstream effector, PKA, play a pivotal role in the anti-neuroinflammatory response of surfactin in LTA-stimulated microglia. surfactin peptide 127-136 heme oxygenase 1 Mus musculus 28-32 23733672-0 2013 Surfactin-induced apoptosis through ROS-ERS-Ca2+-ERK pathways in HepG2 cells. surfactin peptide 0-9 mitogen-activated protein kinase 1 Homo sapiens 49-52 23733672-7 2013 According to a comprehensive review of all the evidence, it is concluded that surfactin induces apoptosis of HepG2 cells through a ROS-ERS-Ca(2+) mediated ERK pathway. surfactin peptide 78-87 mitogen-activated protein kinase 1 Homo sapiens 155-158 25151823-13 2013 In non-infectious conditions, both surfactin and mycosubtilin induced the expression of two peroxidase encoding genes (POX2, POX381), however, the expression of LOX (lipoxygenase), AOS (allene oxide synthase) genes involved in the octadecanoid pathway, as well as of the pathogenesis-related genes PR1 was only induced by mycosubtilin. surfactin peptide 35-44 LOC543232 Triticum aestivum 161-164 25151823-13 2013 In non-infectious conditions, both surfactin and mycosubtilin induced the expression of two peroxidase encoding genes (POX2, POX381), however, the expression of LOX (lipoxygenase), AOS (allene oxide synthase) genes involved in the octadecanoid pathway, as well as of the pathogenesis-related genes PR1 was only induced by mycosubtilin. surfactin peptide 35-44 LOC543232 Triticum aestivum 166-178 25151823-13 2013 In non-infectious conditions, both surfactin and mycosubtilin induced the expression of two peroxidase encoding genes (POX2, POX381), however, the expression of LOX (lipoxygenase), AOS (allene oxide synthase) genes involved in the octadecanoid pathway, as well as of the pathogenesis-related genes PR1 was only induced by mycosubtilin. surfactin peptide 35-44 allene oxide synthase 2 Triticum aestivum 181-184 25151823-13 2013 In non-infectious conditions, both surfactin and mycosubtilin induced the expression of two peroxidase encoding genes (POX2, POX381), however, the expression of LOX (lipoxygenase), AOS (allene oxide synthase) genes involved in the octadecanoid pathway, as well as of the pathogenesis-related genes PR1 was only induced by mycosubtilin. surfactin peptide 35-44 allene oxide synthase 2 Triticum aestivum 186-207 20833156-8 2010 Additionally, we found that small interfering RNA-mediated knock-down of Nrf-2 significantly inhibited surfactin-induced HO-1 expression. surfactin peptide 103-112 NFE2 like bZIP transcription factor 2 Homo sapiens 73-78 23151889-0 2013 Surfactin suppresses TPA-induced breast cancer cell invasion through the inhibition of MMP-9 expression. surfactin peptide 0-9 matrix metallopeptidase 9 Homo sapiens 87-92 23151889-4 2013 Western blot analysis, gelatin zymography and reverse transcription-PCR analysis revealed that matrix metalloproteinase-9 (MMP-9) expression and activation was significantly suppressed by surfactin in a dose-dependent manner. surfactin peptide 224-233 matrix metallopeptidase 9 Homo sapiens 107-145 23151889-4 2013 Western blot analysis, gelatin zymography and reverse transcription-PCR analysis revealed that matrix metalloproteinase-9 (MMP-9) expression and activation was significantly suppressed by surfactin in a dose-dependent manner. surfactin peptide 224-233 matrix metallopeptidase 9 Homo sapiens 147-152 23151889-5 2013 Surfactin attenuated TPA-induced nuclear translocation and activation of nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1). surfactin peptide 0-9 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 123-142 23151889-5 2013 Surfactin attenuated TPA-induced nuclear translocation and activation of nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1). surfactin peptide 0-9 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 156-160 23151889-6 2013 Furthermore, surfactin strongly repressed the TPA-induced phosphorylation of Akt and extracellular signal-regulated kinase (ERK). surfactin peptide 13-22 AKT serine/threonine kinase 1 Homo sapiens 89-92 23151889-6 2013 Furthermore, surfactin strongly repressed the TPA-induced phosphorylation of Akt and extracellular signal-regulated kinase (ERK). surfactin peptide 13-22 mitogen-activated protein kinase 1 Homo sapiens 97-134 23151889-6 2013 Furthermore, surfactin strongly repressed the TPA-induced phosphorylation of Akt and extracellular signal-regulated kinase (ERK). surfactin peptide 13-22 mitogen-activated protein kinase 1 Homo sapiens 136-139 23151889-8 2013 These results suggest that the surfactin-mediated inhibition of breast cancer cell invasion and MMP-9 expression involves the suppression of the NF-kappaB, AP-1, phosphatidylinositol 3-kinase (PI-3K)/Akt and the ERK signaling pathways. surfactin peptide 43-52 matrix metallopeptidase 9 Homo sapiens 120-125 23151889-8 2013 These results suggest that the surfactin-mediated inhibition of breast cancer cell invasion and MMP-9 expression involves the suppression of the NF-kappaB, AP-1, phosphatidylinositol 3-kinase (PI-3K)/Akt and the ERK signaling pathways. surfactin peptide 43-52 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 180-184 23151889-8 2013 These results suggest that the surfactin-mediated inhibition of breast cancer cell invasion and MMP-9 expression involves the suppression of the NF-kappaB, AP-1, phosphatidylinositol 3-kinase (PI-3K)/Akt and the ERK signaling pathways. surfactin peptide 43-52 AKT serine/threonine kinase 1 Homo sapiens 236-239 23151889-8 2013 These results suggest that the surfactin-mediated inhibition of breast cancer cell invasion and MMP-9 expression involves the suppression of the NF-kappaB, AP-1, phosphatidylinositol 3-kinase (PI-3K)/Akt and the ERK signaling pathways. surfactin peptide 43-52 mitogen-activated protein kinase 1 Homo sapiens 248-251 20833156-0 2010 Heme oxygenase-1 signals are involved in preferential inhibition of pro-inflammatory cytokine release by surfactin in cells activated with Porphyromonas gingivalis lipopolysaccharide. surfactin peptide 105-114 heme oxygenase 1 Homo sapiens 0-16 20833156-7 2010 We also examined whether the regulatory effect of surfactin on P. gingivalis LPS-stimulated human THP-1 macrophages was mediated by the induction of heme oxygenase-1 (HO-1) signals, and determined that surfactin also induced HO-1 mRNA and protein expression via activation of Nrf-2. surfactin peptide 50-59 GLI family zinc finger 2 Homo sapiens 98-103 20833156-7 2010 We also examined whether the regulatory effect of surfactin on P. gingivalis LPS-stimulated human THP-1 macrophages was mediated by the induction of heme oxygenase-1 (HO-1) signals, and determined that surfactin also induced HO-1 mRNA and protein expression via activation of Nrf-2. surfactin peptide 50-59 heme oxygenase 1 Homo sapiens 149-165 20833156-7 2010 We also examined whether the regulatory effect of surfactin on P. gingivalis LPS-stimulated human THP-1 macrophages was mediated by the induction of heme oxygenase-1 (HO-1) signals, and determined that surfactin also induced HO-1 mRNA and protein expression via activation of Nrf-2. surfactin peptide 50-59 heme oxygenase 1 Homo sapiens 167-171 20833156-8 2010 Additionally, we found that small interfering RNA-mediated knock-down of Nrf-2 significantly inhibited surfactin-induced HO-1 expression. surfactin peptide 103-112 heme oxygenase 1 Homo sapiens 121-125 20833156-9 2010 Furthermore, inhibition of phosphoinositide 3-kinase (PI3K)/Akt and extracellular signal-regulated kinase (ERK) significantly decreased surfactin-induced HO-1 expression, which is consistent with the suggestion that surfactin-induced HO-1 expression occurs via PI3K/Akt, ERK, and Nrf-2. surfactin peptide 136-145 heme oxygenase 1 Homo sapiens 154-158 20833156-9 2010 Furthermore, inhibition of phosphoinositide 3-kinase (PI3K)/Akt and extracellular signal-regulated kinase (ERK) significantly decreased surfactin-induced HO-1 expression, which is consistent with the suggestion that surfactin-induced HO-1 expression occurs via PI3K/Akt, ERK, and Nrf-2. surfactin peptide 136-145 heme oxygenase 1 Homo sapiens 234-238 20833156-9 2010 Furthermore, inhibition of phosphoinositide 3-kinase (PI3K)/Akt and extracellular signal-regulated kinase (ERK) significantly decreased surfactin-induced HO-1 expression, which is consistent with the suggestion that surfactin-induced HO-1 expression occurs via PI3K/Akt, ERK, and Nrf-2. surfactin peptide 136-145 NFE2 like bZIP transcription factor 2 Homo sapiens 280-285 20833156-9 2010 Furthermore, inhibition of phosphoinositide 3-kinase (PI3K)/Akt and extracellular signal-regulated kinase (ERK) significantly decreased surfactin-induced HO-1 expression, which is consistent with the suggestion that surfactin-induced HO-1 expression occurs via PI3K/Akt, ERK, and Nrf-2. surfactin peptide 216-225 heme oxygenase 1 Homo sapiens 154-158 20833156-9 2010 Furthermore, inhibition of phosphoinositide 3-kinase (PI3K)/Akt and extracellular signal-regulated kinase (ERK) significantly decreased surfactin-induced HO-1 expression, which is consistent with the suggestion that surfactin-induced HO-1 expression occurs via PI3K/Akt, ERK, and Nrf-2. surfactin peptide 216-225 heme oxygenase 1 Homo sapiens 234-238 20833156-9 2010 Furthermore, inhibition of phosphoinositide 3-kinase (PI3K)/Akt and extracellular signal-regulated kinase (ERK) significantly decreased surfactin-induced HO-1 expression, which is consistent with the suggestion that surfactin-induced HO-1 expression occurs via PI3K/Akt, ERK, and Nrf-2. surfactin peptide 216-225 NFE2 like bZIP transcription factor 2 Homo sapiens 280-285 20833156-10 2010 Treatment with a selective inhibitor of HO-1 reversed the surfactin-mediated inhibition of pro-inflammatory cytokines, suggesting that surfactin induces anti-inflammatory effects by activating Nrf-2-mediated HO-1 induction via PI3K/Akt and ERK signaling. surfactin peptide 58-67 heme oxygenase 1 Homo sapiens 40-44 20833156-10 2010 Treatment with a selective inhibitor of HO-1 reversed the surfactin-mediated inhibition of pro-inflammatory cytokines, suggesting that surfactin induces anti-inflammatory effects by activating Nrf-2-mediated HO-1 induction via PI3K/Akt and ERK signaling. surfactin peptide 58-67 NFE2 like bZIP transcription factor 2 Homo sapiens 193-198 20833156-10 2010 Treatment with a selective inhibitor of HO-1 reversed the surfactin-mediated inhibition of pro-inflammatory cytokines, suggesting that surfactin induces anti-inflammatory effects by activating Nrf-2-mediated HO-1 induction via PI3K/Akt and ERK signaling. surfactin peptide 58-67 heme oxygenase 1 Homo sapiens 208-212 20833156-10 2010 Treatment with a selective inhibitor of HO-1 reversed the surfactin-mediated inhibition of pro-inflammatory cytokines, suggesting that surfactin induces anti-inflammatory effects by activating Nrf-2-mediated HO-1 induction via PI3K/Akt and ERK signaling. surfactin peptide 135-144 heme oxygenase 1 Homo sapiens 40-44 20833156-10 2010 Treatment with a selective inhibitor of HO-1 reversed the surfactin-mediated inhibition of pro-inflammatory cytokines, suggesting that surfactin induces anti-inflammatory effects by activating Nrf-2-mediated HO-1 induction via PI3K/Akt and ERK signaling. surfactin peptide 135-144 NFE2 like bZIP transcription factor 2 Homo sapiens 193-198 20833156-10 2010 Treatment with a selective inhibitor of HO-1 reversed the surfactin-mediated inhibition of pro-inflammatory cytokines, suggesting that surfactin induces anti-inflammatory effects by activating Nrf-2-mediated HO-1 induction via PI3K/Akt and ERK signaling. surfactin peptide 135-144 heme oxygenase 1 Homo sapiens 208-212 19954742-0 2010 Surfactin induces apoptosis in human breast cancer MCF-7 cells through a ROS/JNK-mediated mitochondrial/caspase pathway. surfactin peptide 0-9 mitogen-activated protein kinase 8 Homo sapiens 77-80 21116409-0 2010 Characterization and online detection of surfactin isomers based on HPLC-MS(n) analyses and their inhibitory effects on the overproduction of nitric oxide and the release of TNF-alpha and IL-6 in LPS-induced macrophages. surfactin peptide 41-50 tumor necrosis factor Mus musculus 174-183 21116409-0 2010 Characterization and online detection of surfactin isomers based on HPLC-MS(n) analyses and their inhibitory effects on the overproduction of nitric oxide and the release of TNF-alpha and IL-6 in LPS-induced macrophages. surfactin peptide 41-50 interleukin 6 Mus musculus 188-192 21116409-2 2010 Inhibitory activities of surfactin isomers on the overproduction of nitric oxide and the release of TNF-alpha and IL-6 in LPS-induced macrophages were systematically investigated. surfactin peptide 25-34 tumor necrosis factor Mus musculus 100-109 21116409-2 2010 Inhibitory activities of surfactin isomers on the overproduction of nitric oxide and the release of TNF-alpha and IL-6 in LPS-induced macrophages were systematically investigated. surfactin peptide 25-34 interleukin 6 Mus musculus 114-118 21116409-3 2010 It was revealed that the surfactin isomers showed strong inhibitory properties on the overproduction of nitric oxide and the release of IL-6 on LPS-induced murine macrophage cell RAW264.7 with IC(50) values ranging from 1.0 to 7.0 muM. surfactin peptide 25-34 interleukin 6 Mus musculus 136-140 19954742-4 2010 In this study, surfactin caused reactive oxygen species (ROS) generation and the surfactin-induced cell death was prevented by antioxidants N-acetylcysteine (NAC) and catalase, suggesting involvement of ROS generation in surfactin-induced cell death. surfactin peptide 15-24 catalase Homo sapiens 167-175 19954742-4 2010 In this study, surfactin caused reactive oxygen species (ROS) generation and the surfactin-induced cell death was prevented by antioxidants N-acetylcysteine (NAC) and catalase, suggesting involvement of ROS generation in surfactin-induced cell death. surfactin peptide 81-90 catalase Homo sapiens 167-175 19954742-4 2010 In this study, surfactin caused reactive oxygen species (ROS) generation and the surfactin-induced cell death was prevented by antioxidants N-acetylcysteine (NAC) and catalase, suggesting involvement of ROS generation in surfactin-induced cell death. surfactin peptide 81-90 catalase Homo sapiens 167-175 19954742-5 2010 Surfactin induced a sustained activation of the phosphorylation of ERK1/2 and JNK, but not p38. surfactin peptide 0-9 mitogen-activated protein kinase 3 Homo sapiens 67-73 19954742-5 2010 Surfactin induced a sustained activation of the phosphorylation of ERK1/2 and JNK, but not p38. surfactin peptide 0-9 mitogen-activated protein kinase 8 Homo sapiens 78-81 19954742-6 2010 Moreover, surfactin-induced cell death was reversed by PD98059 (an inhibitor of ERK1/2) and SP600125 (an inhibitor of JNK), but not by SB203580 (an inhibitor of p38). surfactin peptide 10-19 mitogen-activated protein kinase 3 Homo sapiens 80-86 19954742-6 2010 Moreover, surfactin-induced cell death was reversed by PD98059 (an inhibitor of ERK1/2) and SP600125 (an inhibitor of JNK), but not by SB203580 (an inhibitor of p38). surfactin peptide 10-19 mitogen-activated protein kinase 8 Homo sapiens 118-121 19954742-7 2010 However, the phosphorylation of JNK rather than ERK1/2 activation by surfactin was blocked by NAC/catalase. surfactin peptide 69-78 mitogen-activated protein kinase 8 Homo sapiens 32-35 19954742-7 2010 However, the phosphorylation of JNK rather than ERK1/2 activation by surfactin was blocked by NAC/catalase. surfactin peptide 69-78 catalase Homo sapiens 98-106 19954742-8 2010 These results suggest that the action of surfactin on MCF-7 cells was via ERK1/2 and JNK, but not via p38, and the ERK1/2 and JNK activation induce apoptosis through two independent signaling mechanisms. surfactin peptide 41-50 mitogen-activated protein kinase 3 Homo sapiens 74-80 19954742-8 2010 These results suggest that the action of surfactin on MCF-7 cells was via ERK1/2 and JNK, but not via p38, and the ERK1/2 and JNK activation induce apoptosis through two independent signaling mechanisms. surfactin peptide 41-50 mitogen-activated protein kinase 8 Homo sapiens 85-88 19954742-8 2010 These results suggest that the action of surfactin on MCF-7 cells was via ERK1/2 and JNK, but not via p38, and the ERK1/2 and JNK activation induce apoptosis through two independent signaling mechanisms. surfactin peptide 41-50 mitogen-activated protein kinase 8 Homo sapiens 126-129 19954742-9 2010 Surfactin triggered the mitochondrial/caspase apoptotic pathway indicated by enhanced Bax-to-Bcl-2 expression ratio, loss of mitochondrial membrane potential, cytochrome c release, and caspase cascade reaction. surfactin peptide 0-9 BCL2 associated X, apoptosis regulator Homo sapiens 86-89 19954742-9 2010 Surfactin triggered the mitochondrial/caspase apoptotic pathway indicated by enhanced Bax-to-Bcl-2 expression ratio, loss of mitochondrial membrane potential, cytochrome c release, and caspase cascade reaction. surfactin peptide 0-9 BCL2 apoptosis regulator Homo sapiens 93-98 19954742-9 2010 Surfactin triggered the mitochondrial/caspase apoptotic pathway indicated by enhanced Bax-to-Bcl-2 expression ratio, loss of mitochondrial membrane potential, cytochrome c release, and caspase cascade reaction. surfactin peptide 0-9 cytochrome c, somatic Homo sapiens 159-171 19954742-12 2010 Taken together, these findings suggest that the surfactin induces apoptosis through a ROS/JNK-mediated mitochondrial/caspase pathway. surfactin peptide 48-57 mitogen-activated protein kinase 8 Homo sapiens 90-93 19669740-5 2009 Western blot revealed that surfactin induced accumulation of the tumor suppressor p53 and cyclin kinase inhibitor p21(waf1/cip1), and inhibited the activity of the G(2)-specific kinase, cyclin B1/p34(cdc2). surfactin peptide 27-36 tumor protein p53 Homo sapiens 82-85 19848391-3 2009 With the micellization of surfactin-C(16), it adopted a beta-sheet conformation, and univalent concentrations reduced micelle micropolarity, increased micelle microviscosity, and tended to cause formation of small and spherical micelles, while divalent counterions had a special effect. surfactin peptide 26-37 amyloid beta precursor protein Homo sapiens 54-60 20222471-5 2009 Immunofluorescence and Western blotting showed that surfactin significantly suppressed the expression of vimentin, induced the alpha-tubulin depolymerization and rearrangement and then the skeleton system of the cells changed dramatically. surfactin peptide 52-61 vimentin Homo sapiens 105-113 19336264-0 2009 Surfactin inhibits immunostimulatory function of macrophages through blocking NK-kappaB, MAPK and Akt pathway. surfactin peptide 0-9 thymoma viral proto-oncogene 1 Mus musculus 98-101 19336264-4 2009 Surfactin significantly suppressed lipopolysaccharide-induced expression of CD40, CD54, CD80, and MHC-II, but not of CD86 and MHC-I. surfactin peptide 0-9 CD40 antigen Mus musculus 76-80 19336264-4 2009 Surfactin significantly suppressed lipopolysaccharide-induced expression of CD40, CD54, CD80, and MHC-II, but not of CD86 and MHC-I. surfactin peptide 0-9 intercellular adhesion molecule 1 Mus musculus 82-86 19336264-4 2009 Surfactin significantly suppressed lipopolysaccharide-induced expression of CD40, CD54, CD80, and MHC-II, but not of CD86 and MHC-I. surfactin peptide 0-9 CD80 antigen Mus musculus 88-92 19336264-4 2009 Surfactin significantly suppressed lipopolysaccharide-induced expression of CD40, CD54, CD80, and MHC-II, but not of CD86 and MHC-I. surfactin peptide 0-9 histocompatibility-2, MHC Mus musculus 98-104 19336264-7 2009 Impaired translocation and activation of NF-kappaB p65 were founded on macrophages exposed to surfactin. surfactin peptide 94-103 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 41-50 19336264-8 2009 In addition, surfactin inhibited the phosphorylation and degradation of IkappaB-alpha, and suppressed the activation of IKK, Akt, JNK and p38 kinase. surfactin peptide 13-22 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 72-85 19336264-8 2009 In addition, surfactin inhibited the phosphorylation and degradation of IkappaB-alpha, and suppressed the activation of IKK, Akt, JNK and p38 kinase. surfactin peptide 13-22 thymoma viral proto-oncogene 1 Mus musculus 125-128 19336264-8 2009 In addition, surfactin inhibited the phosphorylation and degradation of IkappaB-alpha, and suppressed the activation of IKK, Akt, JNK and p38 kinase. surfactin peptide 13-22 mitogen-activated protein kinase 8 Mus musculus 130-133 19336264-8 2009 In addition, surfactin inhibited the phosphorylation and degradation of IkappaB-alpha, and suppressed the activation of IKK, Akt, JNK and p38 kinase. surfactin peptide 13-22 mitogen-activated protein kinase 14 Mus musculus 138-141 19336264-9 2009 These results suggest that surfactin impair the antigen-presenting function of macrophages by inhibiting the expression of MHC-II and costimulatory molecules via suppression of NF-kappaB, p38, JNK and Akt. surfactin peptide 27-36 histocompatibility-2, MHC Mus musculus 123-129 19336264-9 2009 These results suggest that surfactin impair the antigen-presenting function of macrophages by inhibiting the expression of MHC-II and costimulatory molecules via suppression of NF-kappaB, p38, JNK and Akt. surfactin peptide 27-36 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 177-186 19336264-9 2009 These results suggest that surfactin impair the antigen-presenting function of macrophages by inhibiting the expression of MHC-II and costimulatory molecules via suppression of NF-kappaB, p38, JNK and Akt. surfactin peptide 27-36 mitogen-activated protein kinase 14 Mus musculus 188-191 19336264-9 2009 These results suggest that surfactin impair the antigen-presenting function of macrophages by inhibiting the expression of MHC-II and costimulatory molecules via suppression of NF-kappaB, p38, JNK and Akt. surfactin peptide 27-36 mitogen-activated protein kinase 8 Mus musculus 193-196 19336264-9 2009 These results suggest that surfactin impair the antigen-presenting function of macrophages by inhibiting the expression of MHC-II and costimulatory molecules via suppression of NF-kappaB, p38, JNK and Akt. surfactin peptide 27-36 thymoma viral proto-oncogene 1 Mus musculus 201-204 19669740-5 2009 Western blot revealed that surfactin induced accumulation of the tumor suppressor p53 and cyclin kinase inhibitor p21(waf1/cip1), and inhibited the activity of the G(2)-specific kinase, cyclin B1/p34(cdc2). surfactin peptide 27-36 cyclin dependent kinase inhibitor 1A Homo sapiens 90-127 19669740-5 2009 Western blot revealed that surfactin induced accumulation of the tumor suppressor p53 and cyclin kinase inhibitor p21(waf1/cip1), and inhibited the activity of the G(2)-specific kinase, cyclin B1/p34(cdc2). surfactin peptide 27-36 cyclin B1 Homo sapiens 186-195 19669740-5 2009 Western blot revealed that surfactin induced accumulation of the tumor suppressor p53 and cyclin kinase inhibitor p21(waf1/cip1), and inhibited the activity of the G(2)-specific kinase, cyclin B1/p34(cdc2). surfactin peptide 27-36 cyclin H Homo sapiens 196-199 19669740-5 2009 Western blot revealed that surfactin induced accumulation of the tumor suppressor p53 and cyclin kinase inhibitor p21(waf1/cip1), and inhibited the activity of the G(2)-specific kinase, cyclin B1/p34(cdc2). surfactin peptide 27-36 cyclin dependent kinase 1 Homo sapiens 200-204 19136727-3 2008 In this study, NALDI/SiNWs and ITO were tested as potentially useful DESI substrates for selected model analytes (cyclosporine, beauverolide, surfactin and nystatin). surfactin peptide 142-151 desumoylating isopeptidase 2 Homo sapiens 69-73 19131703-0 2008 Surfactin blocks NO production in lipopolysaccharide-activated macrophages by inhibiting NF-kappaB activation. surfactin peptide 0-9 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 89-98 19131703-4 2008 Immunoblotting analysis showed that surfactin strongly blocked the phosphorylation of IKK and IkBa and the nuclear translocation of NF-kappaB (p65). surfactin peptide 36-45 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 132-141 19131703-4 2008 Immunoblotting analysis showed that surfactin strongly blocked the phosphorylation of IKK and IkBa and the nuclear translocation of NF-kappaB (p65). surfactin peptide 36-45 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 143-146 19131703-5 2008 Therefore, these data suggest that surfactin may act as a bacterium-derived antiinflammatory agent with anti-NF-kappaB activity. surfactin peptide 35-44 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 109-118 18983185-4 2008 Surfactin adopts a beta-turn conformation at low micelle concentration but a beta-sheet conformation at high micelle concentration. surfactin peptide 0-9 amyloid beta precursor protein Homo sapiens 17-23 12416979-1 2002 The C-terminal thioesterase domain of the nonribosomal peptide synthetase producing the lipopetide surfactin (Srf TE) retains autonomous ability to generate the cyclic peptidolactone skeleton of surfactin when provided with a soluble beta-hydroxy-butyryl-heptapeptidyl thioester substrate. surfactin peptide 99-108 serum response factor Homo sapiens 110-113 16931339-2 2006 In this study, the potential of COM domains was exploited in vivo by establishing a system for the true biocombinatorial synthesis of lipopeptides via directed reprogramming of a natural NRP biosynthetic assembly line (i.e., surfactin). surfactin peptide 225-234 neuropilin 1 Homo sapiens 187-190 16245181-3 2005 However, surfactin C at 50 microg ml(-1 )inhibited the LPS-induced increase in the transcription of IL-1beta and iNOS and nitric oxide (NO) production in a dose-dependent manner. surfactin peptide 9-20 interleukin 1 beta Mus musculus 100-108 16245181-3 2005 However, surfactin C at 50 microg ml(-1 )inhibited the LPS-induced increase in the transcription of IL-1beta and iNOS and nitric oxide (NO) production in a dose-dependent manner. surfactin peptide 9-20 nitric oxide synthase 2, inducible Mus musculus 113-117 15714297-2 2005 Therefore, to obtain a transformable surfactin producer, the sfp gene cloned from B. subtilis C9 was integrated into the chromosome of B. subtilis 168, a non-surfactin producer, by homologous recombination. surfactin peptide 37-46 sfp Bacillus subtilis subsp. subtilis str. 168 61-64 15714297-2 2005 Therefore, to obtain a transformable surfactin producer, the sfp gene cloned from B. subtilis C9 was integrated into the chromosome of B. subtilis 168, a non-surfactin producer, by homologous recombination. surfactin peptide 158-167 sfp Bacillus subtilis subsp. subtilis str. 168 61-64 16734989-2 2006 Surfactin C strongly and dose-dependently inhibited platelet aggregation, which was stimulated both by thrombin (0.1 U mL(-1)), a potent agonist that activates the G protein-coupled protease receptor, and by collagen (5 microg mL(-1)), a potent ligand that activates alpha(IIb)beta(3) with IC50 values (concentration inhibiting platelet aggregation by 50%) of 10.9 and 17.0 microM, respectively. surfactin peptide 0-11 coagulation factor II, thrombin Homo sapiens 103-111 16734989-3 2006 Moreover, surfactin C significantly suppressed the intracellular Ca(2+) mobilization in thrombin-activated platelets. surfactin peptide 10-21 coagulation factor II, thrombin Homo sapiens 88-96 16568717-6 2006 We confirmed that surfactin inhibited LPS-induced expression of ICAM-1 and VCAM-1 in HUVEC. surfactin peptide 18-27 intercellular adhesion molecule 1 Homo sapiens 64-70 16568717-6 2006 We confirmed that surfactin inhibited LPS-induced expression of ICAM-1 and VCAM-1 in HUVEC. surfactin peptide 18-27 vascular cell adhesion molecule 1 Homo sapiens 75-81 16568717-8 2006 Then, surfactin was shown to suppress the interaction of lipid A with LPS-binding protein (LBP) that mediates the transport of LPS to its receptors. surfactin peptide 6-15 lipopolysaccharide binding protein Homo sapiens 70-89 16568717-8 2006 Then, surfactin was shown to suppress the interaction of lipid A with LPS-binding protein (LBP) that mediates the transport of LPS to its receptors. surfactin peptide 6-15 lipopolysaccharide binding protein Homo sapiens 91-94 16245181-0 2005 Surfactin C inhibits the lipopolysaccharide-induced transcription of interleukin-1beta and inducible nitric oxide synthase and nitric oxide production in murine RAW 264.7 cells. surfactin peptide 0-11 interleukin 1 beta Mus musculus 69-86 16245181-0 2005 Surfactin C inhibits the lipopolysaccharide-induced transcription of interleukin-1beta and inducible nitric oxide synthase and nitric oxide production in murine RAW 264.7 cells. surfactin peptide 0-11 nitric oxide synthase 2, inducible Mus musculus 91-122 34850538-0 2022 Surfactin induces ER stress-mediated apoptosis via IRE1-ASK1-JNK signaling in human osteosarcoma. surfactin peptide 0-9 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 51-55 12007605-2 2002 We have found that a bacterial lipopeptide compound, surfactin C (3-20 microM), enhances the activation of pro-u-PA in the presence of plasminogen. surfactin peptide 53-64 plasminogen activator, urokinase Rattus norvegicus 111-115 12007605-4 2002 Surfactin C also elevated the rate of plasminogen activation by two-chain urokinase (tcu-PA) while not affecting plasmin-catalyzed pro-u-PA activation and amidolytic activities of tcu-PA and plasmin. surfactin peptide 0-11 plasminogen activator, urokinase Rattus norvegicus 87-91 12007605-6 2002 These results suggested that surfactin C induced a relaxation of plasminogen conformation, thus leading to enhancement of u-PA-catalyzed plasminogen activation, which in turn caused feedback pro-u-PA activation. surfactin peptide 29-40 plasminogen activator, urokinase Rattus norvegicus 122-126 12007605-6 2002 These results suggested that surfactin C induced a relaxation of plasminogen conformation, thus leading to enhancement of u-PA-catalyzed plasminogen activation, which in turn caused feedback pro-u-PA activation. surfactin peptide 29-40 plasminogen activator, urokinase Rattus norvegicus 195-199 12007605-7 2002 Surfactin C was active in enhancing [125I]fibrin degradation both by pro-u-PA/plasminogen and tcu-PA/plasminogen systems. surfactin peptide 0-11 plasminogen activator, urokinase Rattus norvegicus 73-77 12696433-3 2002 Surfactins with long fatty acid chain (C14 and C15) showed insecticide effect on the fruit fly, D. melanogaster. surfactin peptide 0-10 C15 Drosophila melanogaster 47-50 12696433-9 2002 We showed that there was a dose-response activity with surfactin C15. surfactin peptide 55-64 C15 Drosophila melanogaster 65-68 33768253-0 2021 A cyclic lipopeptide surfactin is a species-selective Hsp90 inhibitor that suppresses cyanobacterial growth. surfactin peptide 21-30 heat shock protein 90 alpha family class A member 1 Homo sapiens 54-59 33768253-3 2021 We found that a cyclic lipopeptide surfactin inhibits the ATPase activity of Hsp90 from the cyanobacterium Synechococcus elongatus (S. elongatus) PCC 7942 but does not inhibit Escherichia coli (E. coli), yeast and human Hsp90s. surfactin peptide 35-44 heat shock protein 90 alpha family class A member 1 Homo sapiens 77-82 33768253-4 2021 Molecular docking simulations indicated that surfactin could bind to the N-terminal dimerization interface of the cyanobacterial Hsp90 in the ATP- and ADP-bound states, which provided molecular insights into the species-selective inhibition. surfactin peptide 45-54 heat shock protein 90 alpha family class A member 1 Homo sapiens 129-134 33768253-5 2021 The data suggest that surfactin inhibits a rate-limiting conformational change of S. elongatus Hsp90 in the ATP hydrolysis. surfactin peptide 22-31 heat shock protein 90 alpha family class A member 1 Homo sapiens 95-100 33768253-6 2021 Surfactin also inhibited the interaction of the cyanobacterial Hsp90 with a model substrate, and suppressed S. elongatus growth under heat stress, but not that of E. coli. surfactin peptide 0-9 heat shock protein 90 alpha family class A member 1 Homo sapiens 63-68 33768253-8 2021 These results indicate that surfactin inhibits the cellular function of Hsp90 specifically in the cyanobacterium. surfactin peptide 28-37 heat shock protein 90 alpha family class A member 1 Homo sapiens 72-77 34850538-5 2022 Surfactin-induced ER stress not only upregulated of glucose-regulated protein 78/94 and IRE1-ASK1-JNK pathway but also leading to calpains and Bcl-2 proteins family involving the release of cytochrome c. surfactin peptide 0-9 mitogen-activated protein kinase 8 Homo sapiens 98-101 34850538-5 2022 Surfactin-induced ER stress not only upregulated of glucose-regulated protein 78/94 and IRE1-ASK1-JNK pathway but also leading to calpains and Bcl-2 proteins family involving the release of cytochrome c. surfactin peptide 0-9 cytochrome c, somatic Homo sapiens 190-202 34850538-7 2022 In this study, surfactin demonstrated the potential functions to trigger the ER stress, ER stress-associated IRE1-ASK1-JNK signaling pathway, mitochondrial dysfunction, and caspase activations leading to programmed cell apoptosis. surfactin peptide 15-24 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 109-113 34850538-7 2022 In this study, surfactin demonstrated the potential functions to trigger the ER stress, ER stress-associated IRE1-ASK1-JNK signaling pathway, mitochondrial dysfunction, and caspase activations leading to programmed cell apoptosis. surfactin peptide 15-24 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 114-118 34850538-7 2022 In this study, surfactin demonstrated the potential functions to trigger the ER stress, ER stress-associated IRE1-ASK1-JNK signaling pathway, mitochondrial dysfunction, and caspase activations leading to programmed cell apoptosis. surfactin peptide 15-24 mitogen-activated protein kinase 8 Homo sapiens 119-122 11179649-2 2001 The response regulator ComA is primarily activated by ComP, a histidine kinase that mediates response to nutrient conditions and cell density, and the activated ComA is required for transcription of the srf operon, which is essential for the development of genetic competence and surfactin production. surfactin peptide 280-289 COMA Homo sapiens 23-27 11179649-2 2001 The response regulator ComA is primarily activated by ComP, a histidine kinase that mediates response to nutrient conditions and cell density, and the activated ComA is required for transcription of the srf operon, which is essential for the development of genetic competence and surfactin production. surfactin peptide 280-289 COMA Homo sapiens 161-165 10477614-5 1999 The structurally unrelated cPLA2 inhibitors, arachidonyl trifluoromethylketone and surfactin, significantly inhibited eosinophil adhesion to ICAM-1 and VCAM-1 in a concentration-dependent manner. surfactin peptide 83-92 phospholipase A2 group IVA Homo sapiens 27-32 10477614-5 1999 The structurally unrelated cPLA2 inhibitors, arachidonyl trifluoromethylketone and surfactin, significantly inhibited eosinophil adhesion to ICAM-1 and VCAM-1 in a concentration-dependent manner. surfactin peptide 83-92 intercellular adhesion molecule 1 Homo sapiens 141-147 10477614-5 1999 The structurally unrelated cPLA2 inhibitors, arachidonyl trifluoromethylketone and surfactin, significantly inhibited eosinophil adhesion to ICAM-1 and VCAM-1 in a concentration-dependent manner. surfactin peptide 83-92 vascular cell adhesion molecule 1 Homo sapiens 152-158 9605421-0 1998 Suppression of inflammatory responses by surfactin, a selective inhibitor of platelet cytosolic phospholipase A2. surfactin peptide 41-50 phospholipase A2 group IVA Rattus norvegicus 86-112 9605421-1 1998 Surfactin inhibits platelet and spleen cytosolic 100 kDa phospholipase A2 (PLA2). surfactin peptide 0-9 phospholipase A2 group IB Rattus norvegicus 57-73 9605421-1 1998 Surfactin inhibits platelet and spleen cytosolic 100 kDa phospholipase A2 (PLA2). surfactin peptide 0-9 phospholipase A2 group IB Rattus norvegicus 75-79 9605421-8 1998 Surfactin blocked non-stimulated and calcium ionophore A23187-stimulated release of arachidonic acid from monkey kidney CV-1 cells, which contain a cytosolic 100 kDa PLA2 as the major activity, as shown in an anionic exchange DEAE-5PW high performance liquid chromatography profile and western blotting analysis. surfactin peptide 0-9 phospholipase A2 group IB Rattus norvegicus 166-170 9605421-11 1998 These results demonstrate that surfactin is a selective inhibitor for cytosolic PLA2 and a putative anti-inflammatory agent through the inhibitory effect produced by direct interaction with cytosolic PLA2, and that inhibition of cytosolic PLA2 activity may suppress inflammatory responses. surfactin peptide 31-40 phospholipase A2 group IB Rattus norvegicus 80-84 9605421-11 1998 These results demonstrate that surfactin is a selective inhibitor for cytosolic PLA2 and a putative anti-inflammatory agent through the inhibitory effect produced by direct interaction with cytosolic PLA2, and that inhibition of cytosolic PLA2 activity may suppress inflammatory responses. surfactin peptide 31-40 phospholipase A2 group IB Rattus norvegicus 200-204 9605421-11 1998 These results demonstrate that surfactin is a selective inhibitor for cytosolic PLA2 and a putative anti-inflammatory agent through the inhibitory effect produced by direct interaction with cytosolic PLA2, and that inhibition of cytosolic PLA2 activity may suppress inflammatory responses. surfactin peptide 31-40 phospholipase A2 group IB Rattus norvegicus 200-204 34850538-0 2022 Surfactin induces ER stress-mediated apoptosis via IRE1-ASK1-JNK signaling in human osteosarcoma. surfactin peptide 0-9 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 56-60 34850538-0 2022 Surfactin induces ER stress-mediated apoptosis via IRE1-ASK1-JNK signaling in human osteosarcoma. surfactin peptide 0-9 mitogen-activated protein kinase 8 Homo sapiens 61-64 34850538-4 2022 Surfactin triggers ER stress mechanism by promoting the aberrant Ca2+ release from ER lumen and ER-signaling to mitochondrial dysfunction following caspases activation mediating cell apoptosis. surfactin peptide 0-9 caspase 9 Homo sapiens 148-156 34850538-5 2022 Surfactin-induced ER stress not only upregulated of glucose-regulated protein 78/94 and IRE1-ASK1-JNK pathway but also leading to calpains and Bcl-2 proteins family involving the release of cytochrome c. surfactin peptide 0-9 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 88-92 34850538-5 2022 Surfactin-induced ER stress not only upregulated of glucose-regulated protein 78/94 and IRE1-ASK1-JNK pathway but also leading to calpains and Bcl-2 proteins family involving the release of cytochrome c. surfactin peptide 0-9 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 93-97 34716926-0 2022 Surfactin reduces particulate matter-induced VCAM-1-dependent monocyte adhesion in human gingival fibroblasts by increasing Nrf2-dependent HO-1 expression. surfactin peptide 0-9 vascular cell adhesion molecule 1 Homo sapiens 45-51 34716926-0 2022 Surfactin reduces particulate matter-induced VCAM-1-dependent monocyte adhesion in human gingival fibroblasts by increasing Nrf2-dependent HO-1 expression. surfactin peptide 0-9 NFE2 like bZIP transcription factor 2 Homo sapiens 124-128 34716926-0 2022 Surfactin reduces particulate matter-induced VCAM-1-dependent monocyte adhesion in human gingival fibroblasts by increasing Nrf2-dependent HO-1 expression. surfactin peptide 0-9 heme oxygenase 1 Homo sapiens 139-143 34716926-3 2022 As surfactin has potential to induce Nrf2 activation and HO-1 expression, this study aimed to investigate the anti-inflammatory effects of surfactin on PM-exposed human gingival fibroblasts (HGFs) and signaling pathways engaged by surfactin. surfactin peptide 3-12 NFE2 like bZIP transcription factor 2 Homo sapiens 37-41 34716926-3 2022 As surfactin has potential to induce Nrf2 activation and HO-1 expression, this study aimed to investigate the anti-inflammatory effects of surfactin on PM-exposed human gingival fibroblasts (HGFs) and signaling pathways engaged by surfactin. surfactin peptide 3-12 heme oxygenase 1 Homo sapiens 57-61 34716926-3 2022 As surfactin has potential to induce Nrf2 activation and HO-1 expression, this study aimed to investigate the anti-inflammatory effects of surfactin on PM-exposed human gingival fibroblasts (HGFs) and signaling pathways engaged by surfactin. surfactin peptide 139-148 NFE2 like bZIP transcription factor 2 Homo sapiens 37-41 34716926-3 2022 As surfactin has potential to induce Nrf2 activation and HO-1 expression, this study aimed to investigate the anti-inflammatory effects of surfactin on PM-exposed human gingival fibroblasts (HGFs) and signaling pathways engaged by surfactin. surfactin peptide 139-148 heme oxygenase 1 Homo sapiens 57-61 34716926-3 2022 As surfactin has potential to induce Nrf2 activation and HO-1 expression, this study aimed to investigate the anti-inflammatory effects of surfactin on PM-exposed human gingival fibroblasts (HGFs) and signaling pathways engaged by surfactin. surfactin peptide 231-240 NFE2 like bZIP transcription factor 2 Homo sapiens 37-41 34716926-3 2022 As surfactin has potential to induce Nrf2 activation and HO-1 expression, this study aimed to investigate the anti-inflammatory effects of surfactin on PM-exposed human gingival fibroblasts (HGFs) and signaling pathways engaged by surfactin. surfactin peptide 231-240 heme oxygenase 1 Homo sapiens 57-61 34716926-9 2022 One dose of surfactin was given to mice before PM treatment to explore its in vivo effect on VCAM-1 expression in gingival tissues. surfactin peptide 12-21 vascular cell adhesion molecule 1 Mus musculus 93-99 34716926-11 2022 Surfactin could attenuate monocyte adhesion by disrupting this VCAM-1-dependent pathway. surfactin peptide 0-9 vascular cell adhesion molecule 1 Mus musculus 63-69 34716926-12 2022 Additionally, surfactin promoted Nrf2-dependent HO-1 expression in HGFs, mitigating VCAM-1 expression. surfactin peptide 14-23 nuclear factor, erythroid derived 2, like 2 Mus musculus 33-37 34716926-12 2022 Additionally, surfactin promoted Nrf2-dependent HO-1 expression in HGFs, mitigating VCAM-1 expression. surfactin peptide 14-23 heme oxygenase 1 Mus musculus 48-52 34716926-12 2022 Additionally, surfactin promoted Nrf2-dependent HO-1 expression in HGFs, mitigating VCAM-1 expression. surfactin peptide 14-23 vascular cell adhesion molecule 1 Mus musculus 84-90 34716926-13 2022 PM-treated mice exhibited the lower expression of IL-6 and VCAM-1 in gingival tissues if they previously received surfactin. surfactin peptide 114-123 interleukin 6 Mus musculus 50-54 34716926-13 2022 PM-treated mice exhibited the lower expression of IL-6 and VCAM-1 in gingival tissues if they previously received surfactin. surfactin peptide 114-123 vascular cell adhesion molecule 1 Mus musculus 59-65 34716926-14 2022 CONCLUSION: Surfactin exerts anti-inflammatory effects against PM-induced inflammatory responses in HGFs by inhibiting VCAM-1-dependent pathway and inducing Nrf2/HO-1 axis. surfactin peptide 12-21 vascular cell adhesion molecule 1 Mus musculus 119-125 34716926-14 2022 CONCLUSION: Surfactin exerts anti-inflammatory effects against PM-induced inflammatory responses in HGFs by inhibiting VCAM-1-dependent pathway and inducing Nrf2/HO-1 axis. surfactin peptide 12-21 nuclear factor, erythroid derived 2, like 2 Mus musculus 157-161 34716926-14 2022 CONCLUSION: Surfactin exerts anti-inflammatory effects against PM-induced inflammatory responses in HGFs by inhibiting VCAM-1-dependent pathway and inducing Nrf2/HO-1 axis. surfactin peptide 12-21 heme oxygenase 1 Mus musculus 162-166 34565366-0 2021 Influence of B. subtilis 3NA mutations in spo0A and abrB on surfactin production in B. subtilis 168. surfactin peptide 60-69 response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT Bacillus subtilis subsp. subtilis str. 168 42-47 34233232-6 2021 Surfactin significantly enhanced levels of IgE and immune-enhancing mediators, such as interferon-gamma, interleukin (IL)-2, IL-6, IL-12, and tumor necrosis factor-alpha in serum and melanoma tissues. surfactin peptide 0-9 interferon gamma Mus musculus 87-103 34233232-6 2021 Surfactin significantly enhanced levels of IgE and immune-enhancing mediators, such as interferon-gamma, interleukin (IL)-2, IL-6, IL-12, and tumor necrosis factor-alpha in serum and melanoma tissues. surfactin peptide 0-9 interleukin 2 Mus musculus 105-123 34233232-6 2021 Surfactin significantly enhanced levels of IgE and immune-enhancing mediators, such as interferon-gamma, interleukin (IL)-2, IL-6, IL-12, and tumor necrosis factor-alpha in serum and melanoma tissues. surfactin peptide 0-9 interleukin 6 Mus musculus 125-129 34233232-6 2021 Surfactin significantly enhanced levels of IgE and immune-enhancing mediators, such as interferon-gamma, interleukin (IL)-2, IL-6, IL-12, and tumor necrosis factor-alpha in serum and melanoma tissues. surfactin peptide 0-9 tumor necrosis factor Mus musculus 142-169 34233232-7 2021 Activities of caspase-3, 8, and 9 were significantly enhanced by oral administration of surfactin. surfactin peptide 88-97 caspase 3 Mus musculus 14-23 34233232-8 2021 In vitro model, surfactin significantly increased B16F10 cell death via activation of caspase-3, 8, and 9 in a dose-dependent manner. surfactin peptide 16-25 caspase 3 Mus musculus 86-95 34713601-12 2021 In contrast, degQ deletion in DSM10T increased surfactin titer by threefold but decreased plipastatin production by fivefold. surfactin peptide 47-56 pleiotropic regulator Bacillus subtilis subsp. subtilis str. 168 13-17 34486757-0 2021 Surfactin attenuates particulate matter-induced COX-2-dependent PGE2 production in human gingival fibroblasts by inhibiting TLR2 and TLR4/MyD88/NADPH oxidase/ROS/PI3K/Akt/NF-kappaB signaling pathway. surfactin peptide 0-9 mitochondrially encoded cytochrome c oxidase II Homo sapiens 48-53 34486757-0 2021 Surfactin attenuates particulate matter-induced COX-2-dependent PGE2 production in human gingival fibroblasts by inhibiting TLR2 and TLR4/MyD88/NADPH oxidase/ROS/PI3K/Akt/NF-kappaB signaling pathway. surfactin peptide 0-9 toll like receptor 2 Homo sapiens 124-128 34486757-0 2021 Surfactin attenuates particulate matter-induced COX-2-dependent PGE2 production in human gingival fibroblasts by inhibiting TLR2 and TLR4/MyD88/NADPH oxidase/ROS/PI3K/Akt/NF-kappaB signaling pathway. surfactin peptide 0-9 toll like receptor 4 Homo sapiens 133-137 34486757-0 2021 Surfactin attenuates particulate matter-induced COX-2-dependent PGE2 production in human gingival fibroblasts by inhibiting TLR2 and TLR4/MyD88/NADPH oxidase/ROS/PI3K/Akt/NF-kappaB signaling pathway. surfactin peptide 0-9 MYD88 innate immune signal transduction adaptor Homo sapiens 138-143 34486757-0 2021 Surfactin attenuates particulate matter-induced COX-2-dependent PGE2 production in human gingival fibroblasts by inhibiting TLR2 and TLR4/MyD88/NADPH oxidase/ROS/PI3K/Akt/NF-kappaB signaling pathway. surfactin peptide 0-9 AKT serine/threonine kinase 1 Homo sapiens 167-170 34486757-0 2021 Surfactin attenuates particulate matter-induced COX-2-dependent PGE2 production in human gingival fibroblasts by inhibiting TLR2 and TLR4/MyD88/NADPH oxidase/ROS/PI3K/Akt/NF-kappaB signaling pathway. surfactin peptide 0-9 nuclear factor kappa B subunit 1 Homo sapiens 171-180 34486757-15 2021 PM-induced COX-2/PGE2 increase was effectively reversed by surfactin through the disruption of regulatory pathway. surfactin peptide 59-68 mitochondrially encoded cytochrome c oxidase II Homo sapiens 11-16 34716970-3 2022 The contents of fengycin and surfactin varied within the range of 116.24-129.80 mg/L and 34.03-63.11 mg/L in the culture media containing K+ , Na+ and Mg2+ , while the levels were 0.86 and 0.63 mg/L in the media containing Ca2+ . surfactin peptide 29-38 carbonic anhydrase 2 Octodon degus 223-226 34101233-8 2021 What"s more, surfactin significantly inhibited the expression of interleukine-1beta (IL-1beta), interleukine-8 (IL-8), TNF-alpha, nitric oxide (NO), NF-kappaBp65, COX-2, iNOS and increased the expression of interleukine-10 (IL-10). surfactin peptide 13-22 tumor necrosis factor Mus musculus 119-128 34101233-8 2021 What"s more, surfactin significantly inhibited the expression of interleukine-1beta (IL-1beta), interleukine-8 (IL-8), TNF-alpha, nitric oxide (NO), NF-kappaBp65, COX-2, iNOS and increased the expression of interleukine-10 (IL-10). surfactin peptide 13-22 prostaglandin-endoperoxide synthase 2 Mus musculus 163-168 34101233-8 2021 What"s more, surfactin significantly inhibited the expression of interleukine-1beta (IL-1beta), interleukine-8 (IL-8), TNF-alpha, nitric oxide (NO), NF-kappaBp65, COX-2, iNOS and increased the expression of interleukine-10 (IL-10). surfactin peptide 13-22 nitric oxide synthase 2, inducible Mus musculus 170-174 34565366-3 2021 As previous studies have shown, a non-sporulating B. subtilis strain 3NA encoding a functional sfp locus but mutations in the spo0A and abrB loci, called JABs32, exhibits noticeably increased surfactin production capabilities. surfactin peptide 192-201 response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT Bacillus subtilis subsp. subtilis str. 168 126-131 34565366-4 2021 In this work, the impacts of introducing JABs32 mutations in the genes spo0A, abrB and abh from 3NA into strain KM1016, a surfactin-forming derivative of B. subtilis 168, was investigated. surfactin peptide 122-131 response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT Bacillus subtilis subsp. subtilis str. 168 71-76 34565366-9 2021 Deletion of spo0A led to increased growth rates with lowered surfactin titers, while deletion or elongation of abrB resulted in lowered growth rates and high surfactin yields, compared to KM1016. surfactin peptide 61-70 response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT Bacillus subtilis subsp. subtilis str. 168 12-17 34181793-4 2021 RESULTS: Surfactin was able to induce apoptosis through NADPH oxidase/ROS/ER stress/calcium-downregulated extracellular signal-regulated kinases 1/2 pathway. surfactin peptide 9-18 dual oxidase 2 Homo sapiens 56-69 34181793-6 2021 Cell cycle arrest at G2 /M phase caused by surfactin was demonstrated through p53 and p21 accumulation combined p34cdc2 , phosphorylated p34cdc2 and cyclin B1 inhibition, which was regulated by NADPH oxidase-derived ROS. surfactin peptide 43-52 tumor protein p53 Homo sapiens 78-81 34181793-6 2021 Cell cycle arrest at G2 /M phase caused by surfactin was demonstrated through p53 and p21 accumulation combined p34cdc2 , phosphorylated p34cdc2 and cyclin B1 inhibition, which was regulated by NADPH oxidase-derived ROS. surfactin peptide 43-52 cyclin dependent kinase inhibitor 1A Homo sapiens 86-89 34181793-6 2021 Cell cycle arrest at G2 /M phase caused by surfactin was demonstrated through p53 and p21 accumulation combined p34cdc2 , phosphorylated p34cdc2 and cyclin B1 inhibition, which was regulated by NADPH oxidase-derived ROS. surfactin peptide 43-52 cyclin dependent kinase 1 Homo sapiens 112-119 34181793-6 2021 Cell cycle arrest at G2 /M phase caused by surfactin was demonstrated through p53 and p21 accumulation combined p34cdc2 , phosphorylated p34cdc2 and cyclin B1 inhibition, which was regulated by NADPH oxidase-derived ROS. surfactin peptide 43-52 cyclin dependent kinase 1 Homo sapiens 137-144 34181793-6 2021 Cell cycle arrest at G2 /M phase caused by surfactin was demonstrated through p53 and p21 accumulation combined p34cdc2 , phosphorylated p34cdc2 and cyclin B1 inhibition, which was regulated by NADPH oxidase-derived ROS. surfactin peptide 43-52 cyclin B1 Homo sapiens 149-158 34181793-6 2021 Cell cycle arrest at G2 /M phase caused by surfactin was demonstrated through p53 and p21 accumulation combined p34cdc2 , phosphorylated p34cdc2 and cyclin B1 inhibition, which was regulated by NADPH oxidase-derived ROS. surfactin peptide 43-52 dual oxidase 2 Homo sapiens 194-207 35185844-11 2022 Furthermore, typical ROS scavenging enzymes catalase (CAT) and superoxide dismutase (SOD) were also significantly reduced in P. aeruginosa PAO1 and MRSA after treated with fengycin and surfactin, respectively. surfactin peptide 185-194 catalase Pseudomonas aeruginosa PAO1 44-52 35185844-11 2022 Furthermore, typical ROS scavenging enzymes catalase (CAT) and superoxide dismutase (SOD) were also significantly reduced in P. aeruginosa PAO1 and MRSA after treated with fengycin and surfactin, respectively. surfactin peptide 185-194 catalase Pseudomonas aeruginosa PAO1 54-57 35185844-12 2022 Therefore, the inhibition mechanisms of fengycin against P. aeruginosa PAO1 and surfactin against MRSA are closely related with accumulation of ROS, which might be due to the decreased activity of CAT and SOD after treated with fengycin and surfactin, respectively. surfactin peptide 80-89 catalase Pseudomonas aeruginosa PAO1 197-200