PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
9660190-10	1998	The NikC protein belongs to a novel family of pyridoxamine or pyridoxal-phosphate-dependent dehydrases and aminotransferases, some of which are involved in dideoxy- and deoxyaminosugar biosynthesis.	Pyridoxal	62-71	relaxosome accessory protein	Escherichia coli	4-8
9354586-2	1997	After a preliminary screening of drugs to determine their potential inhibitory effect on erythrocyte nonpurified pyridoxal kinase (PLK) (EC 2.7.1.35), additional investigations, including kinetic studies and detection of chemical reactivity between the inhibiting drugs and pyridoxal (PL) or pyridoxal-5"-phosphate (PLP), using UV-visible spectrophotometry and mass analysis, were carried out to specify the mechanism of PLK inhibition.	Pyridoxal	113-122	pyridoxal kinase	Homo sapiens	131-134
9762356-7	1998	The experimental bone pit formation, i.e., osteoclastic bone collagen degradation test, induced by parathyroid hormone was markedly suppressed by the administration of pyridoxal, because of the inhibition of cathepsin L type cysteine proteases in bone.	Pyridoxal	168-177	cathepsin L	Homo sapiens	208-219
9354586-2	1997	After a preliminary screening of drugs to determine their potential inhibitory effect on erythrocyte nonpurified pyridoxal kinase (PLK) (EC 2.7.1.35), additional investigations, including kinetic studies and detection of chemical reactivity between the inhibiting drugs and pyridoxal (PL) or pyridoxal-5"-phosphate (PLP), using UV-visible spectrophotometry and mass analysis, were carried out to specify the mechanism of PLK inhibition.	Pyridoxal	131-133	pyridoxal kinase	Homo sapiens	113-129
8833223-2	1996	The production of PLP from pyridoxal (PL) by pyridoxal kinase (PLK) was inhibited by the addition of dopamine (DA), norepinephrine (NE) and 5-hydroxytryptamine (5-HT), but not by that of epinephrine and N-acetyl-serotonin.	Pyridoxal	27-36	pyridoxal (pyridoxine, vitamin B6) kinase	Mus musculus	45-61
8833223-2	1996	The production of PLP from pyridoxal (PL) by pyridoxal kinase (PLK) was inhibited by the addition of dopamine (DA), norepinephrine (NE) and 5-hydroxytryptamine (5-HT), but not by that of epinephrine and N-acetyl-serotonin.	Pyridoxal	27-36	pyridoxal (pyridoxine, vitamin B6) kinase	Mus musculus	63-66
8833223-2	1996	The production of PLP from pyridoxal (PL) by pyridoxal kinase (PLK) was inhibited by the addition of dopamine (DA), norepinephrine (NE) and 5-hydroxytryptamine (5-HT), but not by that of epinephrine and N-acetyl-serotonin.	Pyridoxal	18-20	pyridoxal (pyridoxine, vitamin B6) kinase	Mus musculus	45-61
8833223-2	1996	The production of PLP from pyridoxal (PL) by pyridoxal kinase (PLK) was inhibited by the addition of dopamine (DA), norepinephrine (NE) and 5-hydroxytryptamine (5-HT), but not by that of epinephrine and N-acetyl-serotonin.	Pyridoxal	18-20	pyridoxal (pyridoxine, vitamin B6) kinase	Mus musculus	63-66
8833223-4	1996	The conjugated product of PLP with DA was also detected by HPLC analysis when PLK activity was assayed using PL as a substrate in the presence of DA.	Pyridoxal	26-28	pyridoxal (pyridoxine, vitamin B6) kinase	Mus musculus	78-81
2208740-8	1990	The main fluorescent metabolite of isopyridoxal present in plasma and urine had a similar retention time to "Peak 1" metabolite.	Pyridoxal	35-47	pseudopodium enriched atypical kinase 1	Homo sapiens	109-115
8584668-6	1995	The nature of the organic cofactor of these enzymes is discussed and data are presented which have identified pyridoxal in pig kidney diamine oxidase and in pig plasma benzylamine oxidase by gas chromatography-mass spectrometry.	Pyridoxal	110-119	amine oxidase copper containing 1	Sus scrofa	134-149
7978244-5	1994	The reported results show that pig kidney diamine oxidase contains pyridoxal in the form of covalently linked pyridoxal phosphate which can be released from the enzyme only by chemical hydrolysis.	Pyridoxal	67-76	amine oxidase copper containing 1	Sus scrofa	42-57
8297098-1	1993	We have demonstrated, using confocal laser scanning microscopy, that pyridoxal treatment of B16C3 murine melanoma cells inhibits triamcinolone acetonide induced translocation of the glucocorticoid receptor to the nucleus of intact cells.	Pyridoxal	69-78	nuclear receptor subfamily 3, group C, member 1	Mus musculus	182-205
8297098-2	1993	In addition to inhibiting glucocorticoid receptor nuclear translocation, pyridoxal kills B16C3 murine melanoma cells and WM983A human melanoma cells in culture.	Pyridoxal	73-82	nuclear receptor subfamily 3, group C, member 1	Mus musculus	26-49
8297098-4	1993	This mechanism, however, appears to initiate in the glucocorticoid receptor signal transducing cascade at a point prior to the impact of pyridoxal treatment alone.	Pyridoxal	137-146	nuclear receptor subfamily 3, group C, member 1	Mus musculus	52-75
1939126-6	1991	This suggests that phosphorylation of pyridoxal can occur via direct transfer of the phosphoryl group between the bound substrates at the active site of pyridoxal kinase.	Pyridoxal	38-47	pyridoxal kinase	Ovis aries	153-169
1898584-1	1991	The response of premature infants to intravenous pyridoxine or pyridoxal was studied by measuring serum and erythrocyte pyridoxal 5"-phosphate (PLP).	Pyridoxal	63-72	pyridoxal phosphatase	Homo sapiens	144-147
2226465-0	1990	Binding of a photoaffinity analogue of pyridoxal to pyridoxal kinase.	Pyridoxal	39-48	pyridoxal kinase	Homo sapiens	52-68
2226465-1	1990	The binding of pyridoxal analogues to the structural domains of pyridoxal kinase was studied by fluorescence spectroscopy and chromatographic techniques.	Pyridoxal	15-24	pyridoxal kinase	Homo sapiens	64-80
34628184-5	2021	PPT-solvent, milk volume, and reconstitution solvent influenced flavin adenine dinucleotide, pyridoxal and nicotinamide recoveries.	Pyridoxal	93-102	palmitoyl-protein thioesterase 1	Homo sapiens	0-3
2394940-7	1990	The aldehydic B6 vitamers, pyridoxal and pyridoxal phosphate, also inhibited ALAD activity when added to the assay mix.	Pyridoxal	27-36	aminolevulinate dehydratase	Rattus norvegicus	77-81
34662241-0	2022	Pyridoxal and alpha-ketoglutarate independently improve function of Saccharomyces cerevisiae Thi5 in the metabolic network of Salmonella enterica.	Pyridoxal	0-9	4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase	Saccharomyces cerevisiae S288C	93-97
34547524-9	2022	B6-dependent seizures in infants with life-threatening HPP were later explained by their profound deficiency of TNSALP activity blocking PLP dephosphorylation to PL and diminishing gamma-hydroxybutyric acid synthesis in the brain.	Pyridoxal	162-164	alkaline phosphatase, biomineralization associated	Homo sapiens	112-118
34817681-1	2022	We report the synthesis, characterization and biological screening of new chromone Schiff bases derived from the condensation of three 6-substituted-3-formyl-chromones with pyridoxal (HL1-3) and its Cu(II) complexes (Cu(L1-3)Cl), 1-3.	Pyridoxal	173-182	asialoglycoprotein receptor 1	Homo sapiens	184-187
3233749-3	1988	In the latter, the percentage of apo alanine aminotransferase was not related to the plasma PLP level, but was significantly correlated with plasma total pyridoxal level and urinary 4-pyridoxic acid excretion.	Pyridoxal	154-163	glutamic--pyruvic transaminase	Homo sapiens	37-61
34072728-9	2021	In addition to the PPI network, ingenuity pathway analysis also implicate TTK, NEK2, and CDK1 in the elevated salvage pyrimidine and pyridoxal pathways in ovarian cancer.	Pyridoxal	133-142	TTK protein kinase	Homo sapiens	74-77
34072728-9	2021	In addition to the PPI network, ingenuity pathway analysis also implicate TTK, NEK2, and CDK1 in the elevated salvage pyrimidine and pyridoxal pathways in ovarian cancer.	Pyridoxal	133-142	NIMA related kinase 2	Homo sapiens	79-83
34072728-9	2021	In addition to the PPI network, ingenuity pathway analysis also implicate TTK, NEK2, and CDK1 in the elevated salvage pyrimidine and pyridoxal pathways in ovarian cancer.	Pyridoxal	133-142	cyclin dependent kinase 1	Homo sapiens	89-93
35067757-3	2022	In the presence of ALP, as a nature substrate, PLP is enzymatically hydrolyzed to form pyridoxal, which cannot interact with PDA nano-liposomes.	Pyridoxal	87-96	alkaline phosphatase, placental	Homo sapiens	19-22
34730814-2	2022	One of the mutants isolated, sos4, encodes a kinase that phosphorylates pyridoxal (PL), a B6 vitamer, forming the important coenzyme pyridoxal 5"-phosphate (PLP).	Pyridoxal	72-81	pfkB-like carbohydrate kinase family protein	Arabidopsis thaliana	29-33
34730814-2	2022	One of the mutants isolated, sos4, encodes a kinase that phosphorylates pyridoxal (PL), a B6 vitamer, forming the important coenzyme pyridoxal 5"-phosphate (PLP).	Pyridoxal	83-85	pfkB-like carbohydrate kinase family protein	Arabidopsis thaliana	29-33
3023054-7	1986	Interestingly, the pyridoxal-binding peptide of porcine DDC matches the Drosophila sequence perfectly suggesting considerable selective pressure on at least portions of the sequence.	Pyridoxal	19-28	Dopa decarboxylase	Drosophila melanogaster	56-59
3533935-3	1986	An inducible pyridoxine 5"-dehydrogenase (oxidase) (EC 1.1.99.9) that catalyzes conversion of pyridoxine to isopyridoxal, Pyridoxine + X----isopyridoxal + XH2, the first step in utilization of pyridoxine as a growth substrate by this organism, was purified about 520-fold to homogeneity.	Pyridoxal	108-120	ATRX chromatin remodeler	Homo sapiens	155-158
2844783-1	1988	Pyridoxal kinase is inactivated by preincubation with the affinity label reagent adenosine tetraphosphate pyridoxal (AP4-PL) at a mixing molar ratio of 5:1 AP4-PL contains structural features of the substrates pyridoxal and ATP.	Pyridoxal	106-115	pyridoxal kinase	Homo sapiens	0-16
2844783-1	1988	Pyridoxal kinase is inactivated by preincubation with the affinity label reagent adenosine tetraphosphate pyridoxal (AP4-PL) at a mixing molar ratio of 5:1 AP4-PL contains structural features of the substrates pyridoxal and ATP.	Pyridoxal	106-115	transcription factor AP-4	Homo sapiens	117-120
2844783-1	1988	Pyridoxal kinase is inactivated by preincubation with the affinity label reagent adenosine tetraphosphate pyridoxal (AP4-PL) at a mixing molar ratio of 5:1 AP4-PL contains structural features of the substrates pyridoxal and ATP.	Pyridoxal	106-115	transcription factor AP-4	Homo sapiens	156-159
2468539-0	1988	Protein lysine 6-oxidase (lysyl oxidase) cofactor: methoxatin (PQQ) or pyridoxal?	Pyridoxal	71-80	lysyl oxidase	Gallus gallus	0-24
3612307-3	1987	PLP is known to be hydrolyzed to pyridoxal (PL) by alkaline phosphatase (ALP), resulting in an inverse relationship between PLP and ALP.	Pyridoxal	33-42	alkaline phosphatase, placental	Homo sapiens	51-71
3612307-3	1987	PLP is known to be hydrolyzed to pyridoxal (PL) by alkaline phosphatase (ALP), resulting in an inverse relationship between PLP and ALP.	Pyridoxal	33-42	alkaline phosphatase, placental	Homo sapiens	73-76
3612307-3	1987	PLP is known to be hydrolyzed to pyridoxal (PL) by alkaline phosphatase (ALP), resulting in an inverse relationship between PLP and ALP.	Pyridoxal	33-42	alkaline phosphatase, placental	Homo sapiens	132-135
3612307-3	1987	PLP is known to be hydrolyzed to pyridoxal (PL) by alkaline phosphatase (ALP), resulting in an inverse relationship between PLP and ALP.	Pyridoxal	0-2	alkaline phosphatase, placental	Homo sapiens	51-71
3612307-3	1987	PLP is known to be hydrolyzed to pyridoxal (PL) by alkaline phosphatase (ALP), resulting in an inverse relationship between PLP and ALP.	Pyridoxal	0-2	alkaline phosphatase, placental	Homo sapiens	73-76
3612307-3	1987	PLP is known to be hydrolyzed to pyridoxal (PL) by alkaline phosphatase (ALP), resulting in an inverse relationship between PLP and ALP.	Pyridoxal	0-2	alkaline phosphatase, placental	Homo sapiens	132-135
6337752-8	1983	The daily oral supplementation with 250-750 mg pyridoxal induces a supraphysiological increase in plasma PLP concentration in hemodialyzed as well as in undialyzed patients.	Pyridoxal	47-56	pyridoxal phosphatase	Homo sapiens	105-108
4055950-1	1985	The determination of pyridoxal-5-phosphate (PLP) and pyridoxal (PL) in plasma requires the availability of dark room facilities, due to the photosensitivity of these vitamin B6 vitamers.	Pyridoxal	21-30	pyridoxal phosphatase	Homo sapiens	44-47
4055950-2	1985	The fact that the semicarbazone forms of PL and PLP are more strongly fluorescent than the underivatized B6 vitamers has been exploited in plasma analyses, but it was not previously realised that these semicarbazone forms are also very stable even under conditions that lead to rapid decomposition of free PL and PLP.	Pyridoxal	41-43	pyridoxal phosphatase	Homo sapiens	313-316
3804610-2	1986	However plasma PLP is in a dynamic equilibrium with pyridoxal (PL) through the action of non specific alkaline phosphatases (ALP).	Pyridoxal	52-61	alkaline phosphatase, biomineralization associated	Canis lupus familiaris	102-123
3804610-2	1986	However plasma PLP is in a dynamic equilibrium with pyridoxal (PL) through the action of non specific alkaline phosphatases (ALP).	Pyridoxal	52-61	alkaline phosphatase, biomineralization associated	Canis lupus familiaris	125-128
3804610-2	1986	However plasma PLP is in a dynamic equilibrium with pyridoxal (PL) through the action of non specific alkaline phosphatases (ALP).	Pyridoxal	15-17	alkaline phosphatase, biomineralization associated	Canis lupus familiaris	102-123
3804610-2	1986	However plasma PLP is in a dynamic equilibrium with pyridoxal (PL) through the action of non specific alkaline phosphatases (ALP).	Pyridoxal	15-17	alkaline phosphatase, biomineralization associated	Canis lupus familiaris	125-128
6337752-14	1983	Its correction with pyridoxal to restore physiological plasma PLP concentration necessitates oral supplementation with lower doses that those widely used at present.	Pyridoxal	20-29	pyridoxal phosphatase	Homo sapiens	62-65
6634429-6	1983	When the vitamin B6 antagonist 4-deoxypyridoxine (which competes with pyridoxal for pyridoxal kinase) was added to the pyridoxal supplemented medium, the inhibition in [3H]uridine incorporation was reduced from 19% to 6%.	Pyridoxal	70-79	pyridoxal kinase	Homo sapiens	84-100
6264054-0	1980	Competitive inhibition between 4"-substituted pyridoxine analogues and pyridoxal for pyridoxal kinase from mouse brain.	Pyridoxal	71-80	pyridoxal (pyridoxine, vitamin B6) kinase	Mus musculus	85-101
7426319-3	1980	Arrest was averted by 3-hydroxybenzyloxyamine, which inactivates the pyridoxal co-factor of PAO.	Pyridoxal	69-78	polyamine oxidase	Homo sapiens	92-95
221500-4	1979	Pyridoxal kinase, 60,000 molecular weight, catalyzes the phosphorylation of pyridoxal (Km = 2.5 x 10(-5) M) and pyridoxine (Km = 1.7 x 10(-5) M).	Pyridoxal	76-85	pyridoxal kinase	Sus scrofa	0-16
214131-1	1978	The reaction of pig kidney diamine oxidase (amine:oxygen oxidoreductase (deaminating) (pyridoxal-containing), EC 1.4.3.6) could be significantly inhibited by superoxide dismutase active copper chelates but not by native 2Cu,2Zn-superoxide dimutase (cuprein).	Pyridoxal	87-96	amine oxidase copper containing 1	Sus scrofa	27-42
191838-1	1977	High histaminase [amine:oxygen oxidoreductase (deaminating) (pyridoxal-containing), EC 1.4.3.6] activity is found in certain human tumors and in the placenta of most mammals.	Pyridoxal	61-70	amine oxidase copper containing 1	Homo sapiens	5-16
96921-8	1978	These results favour the concept of a role of pyridoxal cofactor in the metabolism of diamines, presumably at the diamine oxidase stage.	Pyridoxal	46-55	amine oxidase, copper containing 1	Rattus norvegicus	114-129
14406017-0	1959	Inactivation of antidiuretic activity of vasopressin by hypothalamic tissue in the presence of pyridoxal.	Pyridoxal	95-104	arginine vasopressin	Homo sapiens	41-52
4256441-0	1971	Aldehyde oxidase: catalysis of the oxidation of N 1 -methylnicotinamide and pyridoxal.	Pyridoxal	76-85	aldehyde oxidase 1	Homo sapiens	0-16
4963523-2	1967	The rate of oxidative deamination of 1,5-diaminopentane by pea-seedling extracts, which contain diamine oxidase [diamine-oxygen oxidoreductase (deaminating), EC 1.4.3.6], was increased by adding pyridoxal or pyridoxal phosphate.	Pyridoxal	195-204	amine oxidase copper containing 1	Homo sapiens	96-111
11704-0	1976	Application of a direct spectrophotometric assay employing a chromogenic substrate for tryptophanase to the determination of pyridoxal and pyridoxamine 5"-phosphates.	Pyridoxal	125-134	tryptophan 2,3-dioxygenase	Homo sapiens	87-100
974085-6	1976	It is proposed that the mechanism of inactivation involves Schiff base formation between inactivator and enzyme-bound pyridoxal and subsequent elimination of HC1 from dichloroalanine or HF from trifluoroalanine.	Pyridoxal	118-127	CYCS pseudogene 39	Homo sapiens	158-161
239684-2	1975	Diamine oxidase [amine-oxygen oxidoreductase (deaminating)(pyridoxal-containing), EC 1.4.3.6] was purified from human seminal plasma more than 1,700-fold.	Pyridoxal	59-68	amine oxidase copper containing 1	Homo sapiens	0-15
4359937-7	1974	Further studies with erythrocytes demonstrated that the cellular content of PLP is determined not only by the activities of these PLP-synthesizing enzymes but also by the activity of a phosphate-sensitive, membrane-associated, neutral phosphatase, which hydrolyzes phosphorylated B(6) compounds.Acetaldehyde, but not ethanol, impaired the net formation of PLP from pyridoxal, pyridoxine, and pyridoxine phosphate by erythrocytes.	Pyridoxal	365-374	pyridoxal phosphatase	Homo sapiens	76-79
14820867-0	1951	The enzymic oxidation of pyridoxal by liver aldehyde oxidase.	Pyridoxal	25-34	aldehyde oxidase 1	Homo sapiens	44-60
33318193-5	2020	Partially overlapping binding of artemisinins with the substrate pyridoxal inhibits PLP biosynthesis as demonstrated by kinetic measurements.	Pyridoxal	65-74	pyridoxal phosphatase	Homo sapiens	84-87
34023785-4	2021	By using a metabolite library screen, we showed that pyridoxal (PL) significantly suppresses PD-L1 expression.	Pyridoxal	53-62	CD274 molecule	Sus scrofa	93-98
34023785-4	2021	By using a metabolite library screen, we showed that pyridoxal (PL) significantly suppresses PD-L1 expression.	Pyridoxal	64-66	CD274 molecule	Sus scrofa	93-98
34023785-6	2021	Functionally, PL enhances T cell killing activity by blocking the PD-1/PD-L1 signaling pathway.	Pyridoxal	14-16	CD274 molecule	Sus scrofa	71-76
34023785-7	2021	Thus, we have identified PL as an inhibitor of PD-L1, which provides a feasible option for combination immunotherapy.	Pyridoxal	25-27	CD274 molecule	Sus scrofa	47-52
32105687-1	2020	The enzyme pyridoxal kinase (PdxK) catalyzes the conversion of pyridoxal to pyridoxal-5"-phosphate (PLP) using ATP as the co-factor.	Pyridoxal	11-20	pyridoxal kinase	Homo sapiens	29-33
33045383-3	2020	Entamoeba histolytica depends on the uptake of pyridoxal (PL), a B6 vitamer from the external environment which is then phosphorylated by pyridoxal kinase (EhPLK) to form PLP via the salvage pathway.	Pyridoxal	47-56	pyridoxal phosphatase	Homo sapiens	171-174
33045383-3	2020	Entamoeba histolytica depends on the uptake of pyridoxal (PL), a B6 vitamer from the external environment which is then phosphorylated by pyridoxal kinase (EhPLK) to form PLP via the salvage pathway.	Pyridoxal	58-60	pyridoxal phosphatase	Homo sapiens	171-174
32199201-3	2020	The beta-cyclodextrin (beta-CD) capped ZnO quantum dots (QDs) were decorated with the vitamin B6 cofactors like pyridoxal 5"-phosphate (PLP) and pyridoxal (Py) by forming host-guest inclusion complexation between the capped beta-CD and PLP/Py.	Pyridoxal	112-121	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	23-30
32199201-3	2020	The beta-cyclodextrin (beta-CD) capped ZnO quantum dots (QDs) were decorated with the vitamin B6 cofactors like pyridoxal 5"-phosphate (PLP) and pyridoxal (Py) by forming host-guest inclusion complexation between the capped beta-CD and PLP/Py.	Pyridoxal	156-158	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	23-30
32120288-0	2020	Binding of pyridoxal, pyridoxal 5"-phosphate and derived hydrazones to bovine serum albumin in aqueous solution.	Pyridoxal	11-20	albumin	Bos taurus	78-91
32120288-1	2020	In the present paper, the kinetics of a reaction between bovine serum albumin (BSA) and pyridoxal, pyridoxal 5"-phosphate was studied, apparent rate constant of product formation and dissociation as well as binding constants were determined.	Pyridoxal	88-97	albumin	Bos taurus	64-77
33008889-6	2020	It was saturable as a function of pyridoxine concentration, with an apparent K m of 37.8 and 18.5 muM, for SLC19A2 and SLC19A3, respectively, and inhibited by the pyridoxine analogs pyridoxal and pyridoxamine as well as thiamine.	Pyridoxal	182-191	solute carrier family 19 member 2	Sus scrofa	107-114
33008889-6	2020	It was saturable as a function of pyridoxine concentration, with an apparent K m of 37.8 and 18.5 muM, for SLC19A2 and SLC19A3, respectively, and inhibited by the pyridoxine analogs pyridoxal and pyridoxamine as well as thiamine.	Pyridoxal	182-191	solute carrier family 19 member 3	Sus scrofa	119-126
31711735-4	2020	Upon addition of the ALP, the emission of QDs was restored due to the dephosphorylation and the conversion of the functionalized PLP in to pyridoxal.	Pyridoxal	139-148	alkaline phosphatase, placental	Homo sapiens	21-24
31854983-7	2020	Since the pyridoxal (PL) produced by the acid phosphatase (ACP)-catalyzed cleavage of PLP has a weak interaction with Cys/NAC-AuNC, a novel turn-on fluorescent method for selective detection of ACP was successfully realized.	Pyridoxal	10-19	X-linked Kx blood group	Homo sapiens	122-125
31854983-7	2020	Since the pyridoxal (PL) produced by the acid phosphatase (ACP)-catalyzed cleavage of PLP has a weak interaction with Cys/NAC-AuNC, a novel turn-on fluorescent method for selective detection of ACP was successfully realized.	Pyridoxal	21-23	X-linked Kx blood group	Homo sapiens	122-125
31506944-2	2020	PDXK phosphorylates pyridoxine, pyridoxamine, and pyridoxal by producing PNP, PMP, and PLP, whereas PNPO oxidizes PNP, PMP, into PLP.	Pyridoxal	50-59	Pyridoxal kinase	Drosophila melanogaster	0-4
31088617-3	2019	In our previous study, we replaced pyridoxal-5-phosphate (PLP) with pyridoxal kinase (PdxY) along with pyridoxal (PL) because it could achieve 80% conversion with 0.4 M of l-lysine in 6 h. However, conversion was sharply decreased in the presence of high concentrations of l-lysine (i.e., 1 M), resulting in less than 40% conversion after several hours.	Pyridoxal	35-44	pyridoxal phosphatase	Homo sapiens	58-61
32071829-1	2019	Guanidinocalix[5]arene and fluorescein reporter pair has been chosen to set up a supramolecular tandem assay principle based on the differential recognition of pyridoxal-5"-phosphate (the substrate of alkaline phosphatase, ALP), pyridoxal (the product of ALP) and phosphate (the product of ALP).	Pyridoxal	160-169	ATHS	Homo sapiens	223-226
32071829-1	2019	Guanidinocalix[5]arene and fluorescein reporter pair has been chosen to set up a supramolecular tandem assay principle based on the differential recognition of pyridoxal-5"-phosphate (the substrate of alkaline phosphatase, ALP), pyridoxal (the product of ALP) and phosphate (the product of ALP).	Pyridoxal	160-169	ATHS	Homo sapiens	255-258
32071829-1	2019	Guanidinocalix[5]arene and fluorescein reporter pair has been chosen to set up a supramolecular tandem assay principle based on the differential recognition of pyridoxal-5"-phosphate (the substrate of alkaline phosphatase, ALP), pyridoxal (the product of ALP) and phosphate (the product of ALP).	Pyridoxal	160-169	ATHS	Homo sapiens	255-258
31805132-7	2019	RESULTS: Treatment with a PPARalpha agonist was associated with increased plasma concentrations of most biomarkers, with the most pronounced differences observed for betaine, dimethylglycine, glycine, nicotinamide, methylnicotinamide, pyridoxal and methylmalonic acid.	Pyridoxal	235-244	peroxisome proliferator activated receptor alpha	Rattus norvegicus	26-35
26780217-3	2016	Through a salvage pathway, pyridoxal 5"-phosphate is synthesized from pyridoxal, pyridoxine or pyridoxamine, in a series of reactions catalyzed by pyridoxal kinase and pyridoxine 5"-phosphate oxidase.	Pyridoxal	27-36	pyridoxine/pyridoxamine 5'-phosphate oxidase	Bombyx mori	168-199
30698666-1	2019	BACKGROUND: Increased vitamin B6 catabolism related to inflammation, as measured by the PAr index (the ratio of 4-pyridoxic acid over the sum of pyridoxal and pyridoxal-5"-phosphate), has been positively associated with lung cancer risk in two prospective European studies.	Pyridoxal	145-154	jumping translocation breakpoint	Homo sapiens	88-91
30194028-3	2019	When the co-culture was maintained without pyridoxal, carboxymethylation of collapsin response mediator protein 2 (CRMP2) became detectable.	Pyridoxal	43-52	dihydropyrimidinase like 2	Homo sapiens	76-113
30194028-3	2019	When the co-culture was maintained without pyridoxal, carboxymethylation of collapsin response mediator protein 2 (CRMP2) became detectable.	Pyridoxal	43-52	dihydropyrimidinase like 2	Homo sapiens	115-120
30221719-9	2018	A total of 26 metabolites were identified as hub nodes in the CREG network, 13 of which had salient centrality and fold-changes: Dopamine, carnosine, fumarate, nicotinamide D-ribonucleotide, adenosine monophosphate, pyridoxal, deoxyguanosine triphosphate, L-citrulline, nicotinamide, phenylalanine, deoxyuridine, tryptamine and succinate.	Pyridoxal	216-225	cellular repressor of E1A stimulated genes 1	Homo sapiens	62-66
29503991-1	2018	An easy to prepare novel vitamin B6 cofactor derivative 3-hydroxy-N"-((3 hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl)methylene)-2-naphthohydrazide (NPY) was synthesized by a one pot condensation reaction of pyridoxal with 3-hydroxy-2-naphthoic hydrazide and applied for the optical detection of Zn2+ and cysteine in the aqueous DMSO medium.	Pyridoxal	210-219	neuropeptide Y	Homo sapiens	151-154
29495635-6	2018	This indicates that pyridoxal can also inhibit starch hydrolyzing by pancreatic alpha-amylase in small intestine.	Pyridoxal	20-29	amylase 2a3	Rattus norvegicus	69-93
29187681-2	2018	In this study, we found that excess pyridoxal (PL) in a minimal medium resulted in excess PLP in vivo and growth inhibition, which was alleviated by YbhA overproduction.	Pyridoxal	36-45	YbhA	Escherichia coli	149-153
29187681-2	2018	In this study, we found that excess pyridoxal (PL) in a minimal medium resulted in excess PLP in vivo and growth inhibition, which was alleviated by YbhA overproduction.	Pyridoxal	47-49	YbhA	Escherichia coli	149-153
29187681-3	2018	Conversely, the YbhA overproduction resulted in PLP shortage in vivo and the correlated reduction in growth rate, which was significantly negated by PL in the medium.	Pyridoxal	48-50	YbhA	Escherichia coli	16-20
28083878-7	2017	In human reconstructed epidermis, pyridoxal preincubation followed by UVA exposure caused genomic oxidative base damage, procaspase 3 cleavage and TUNEL positivity, consistent with UVA-driven photooxidative damage that may be relevant to human skin exposed to high concentrations of B6 -vitamers.	Pyridoxal	34-43	caspase 3	Homo sapiens	121-133
27521834-17	2016	In silico docking simulations showed that benserazide binds in the active site of the enzyme and reacts with the PLP cofactor by forming reversible but kinetically stable Schiff base-like adducts with the formyl moiety of pyridoxal.	Pyridoxal	222-231	proteolipid protein 1	Homo sapiens	113-116
26666246-5	2016	This technique allowed detection of increased concentrations of pyridoxal, the substrate of pyridoxal kinase.	Pyridoxal	64-73	pyridoxal (pyridoxine, vitamin B6) kinase	Mus musculus	92-108
27302825-0	2016	Re: Pyridoxamine and Pyridoxal are More Effective than Pyridoxine in Rescuing Folding-Defective Variants of Human Alanine:Glyoxylate Aminotransferase Causing Primary Hyperoxaluria Type I.	Pyridoxal	21-30	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	114-149
26199318-0	2015	Pyridoxamine and pyridoxal are more effective than pyridoxine in rescuing folding-defective variants of human alanine:glyoxylate aminotransferase causing primary hyperoxaluria type I.	Pyridoxal	17-26	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	110-145
25603814-0	2015	Growth suppression and cell death by pyridoxal is dependent on p53 in the human breast cancer cell line MCF-7.	Pyridoxal	37-46	tumor protein p53	Homo sapiens	63-66
25603814-7	2015	The cell growth suppression by 0.5 mM PL did not occur when p53 expression was knocked down using siRNA.	Pyridoxal	38-40	tumor protein p53	Homo sapiens	60-63
25603814-8	2015	Together, these data suggest that PL accumulate p53 and PL-induced cell growth suppression is dependent on p53 in MCF-7 breast cancer cells.	Pyridoxal	34-36	tumor protein p53	Homo sapiens	48-51
25603814-8	2015	Together, these data suggest that PL accumulate p53 and PL-induced cell growth suppression is dependent on p53 in MCF-7 breast cancer cells.	Pyridoxal	34-36	tumor protein p53	Homo sapiens	107-110
25603814-8	2015	Together, these data suggest that PL accumulate p53 and PL-induced cell growth suppression is dependent on p53 in MCF-7 breast cancer cells.	Pyridoxal	56-58	tumor protein p53	Homo sapiens	107-110
24760553-7	2014	The approach used to analyze genetic association with the SAM/SAH metabolites is called middle-out: SNPs in 275 genes involved in the one-carbon pathway (folate, pyridoxal/pyridoxine, thiamin) or were correlated with SAM/SAH (vitamin A, E, Hcy) were analyzed instead of the entire 1M SNP data set.	Pyridoxal	162-171	acyl-CoA synthetase medium chain family member 3	Homo sapiens	58-65
23942851-0	2013	High concentrations of pyridoxal stimulate the expression of IGFBP1 in HepG2 cells through upregulation of the ERK/c-Jun pathway.	Pyridoxal	23-32	insulin like growth factor binding protein 1	Homo sapiens	61-67
24626782-3	2014	The present preliminary study using DNA microarray and real-time PCR indicates p21 mRNA is upregulated in human colon carcinoma (HT29) cells exposed to pyridoxal (PL, 500 microM).	Pyridoxal	152-161	H3 histone pseudogene 16	Homo sapiens	79-82
24626782-3	2014	The present preliminary study using DNA microarray and real-time PCR indicates p21 mRNA is upregulated in human colon carcinoma (HT29) cells exposed to pyridoxal (PL, 500 microM).	Pyridoxal	163-165	H3 histone pseudogene 16	Homo sapiens	79-82
24626782-7	2014	PL increased the phosphorylated p53 protein levels (active form) in whole-cell lysates and the nuclei of the cells.	Pyridoxal	0-2	tumor protein p53	Homo sapiens	32-35
24074277-5	2013	The pyridoxal-based manganese complexes of NO2(-) and NO3(-) have been isolated, and their structures have been established by single-crystal XRD.	Pyridoxal	4-13	NBL1, DAN family BMP antagonist	Homo sapiens	54-60
23942851-0	2013	High concentrations of pyridoxal stimulate the expression of IGFBP1 in HepG2 cells through upregulation of the ERK/c-Jun pathway.	Pyridoxal	23-32	mitogen-activated protein kinase 1	Homo sapiens	111-114
23942851-0	2013	High concentrations of pyridoxal stimulate the expression of IGFBP1 in HepG2 cells through upregulation of the ERK/c-Jun pathway.	Pyridoxal	23-32	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	115-120
23942851-3	2013	Preliminary results in the current study indicated, following DNA microarray analysis and quantitative PCR, that insulin-like growth factor-binding protein 1 (IGFBP1) mRNA is upregulated in HT29 colon carcinoma cells exposed to pyridoxal (PL, 500 microM).	Pyridoxal	228-237	insulin like growth factor binding protein 1	Homo sapiens	113-157
23942851-3	2013	Preliminary results in the current study indicated, following DNA microarray analysis and quantitative PCR, that insulin-like growth factor-binding protein 1 (IGFBP1) mRNA is upregulated in HT29 colon carcinoma cells exposed to pyridoxal (PL, 500 microM).	Pyridoxal	228-237	insulin like growth factor binding protein 1	Homo sapiens	159-165
23942851-3	2013	Preliminary results in the current study indicated, following DNA microarray analysis and quantitative PCR, that insulin-like growth factor-binding protein 1 (IGFBP1) mRNA is upregulated in HT29 colon carcinoma cells exposed to pyridoxal (PL, 500 microM).	Pyridoxal	239-241	insulin like growth factor binding protein 1	Homo sapiens	113-157
23942851-3	2013	Preliminary results in the current study indicated, following DNA microarray analysis and quantitative PCR, that insulin-like growth factor-binding protein 1 (IGFBP1) mRNA is upregulated in HT29 colon carcinoma cells exposed to pyridoxal (PL, 500 microM).	Pyridoxal	239-241	insulin like growth factor binding protein 1	Homo sapiens	159-165
23942851-5	2013	Thus, further experiments were performed to investigate the effect of PL on the expression of IGFBP1 in HepG2 hepatocellular carcinoma cells.	Pyridoxal	70-72	insulin like growth factor binding protein 1	Homo sapiens	94-100
23942851-6	2013	The addition of PL (500 microM) markedly increased the expression of IGFBP1 mRNA in HepG2 cells at 6, 12 and 24 h (P<0.01), whereas other vitamers (500 microM), including pyridoxal 5"-phosphate (PLP), pyridoxine (PN) and pyridoxamine (PM), caused no such effect.	Pyridoxal	16-18	insulin like growth factor binding protein 1	Homo sapiens	69-75
23942851-10	2013	Higher expression of IGFBP1 protein by PL was suppressed by cycloheximide.	Pyridoxal	39-41	insulin like growth factor binding protein 1	Homo sapiens	21-27
23942851-11	2013	These results suggest that PL may induce the expression of IGFBP1 in hepatoma cells via a mechanism involving the ERK/c-Jun pathway.	Pyridoxal	27-29	insulin like growth factor binding protein 1	Homo sapiens	59-65
23942851-11	2013	These results suggest that PL may induce the expression of IGFBP1 in hepatoma cells via a mechanism involving the ERK/c-Jun pathway.	Pyridoxal	27-29	mitogen-activated protein kinase 1	Homo sapiens	114-117
23942851-11	2013	These results suggest that PL may induce the expression of IGFBP1 in hepatoma cells via a mechanism involving the ERK/c-Jun pathway.	Pyridoxal	27-29	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	118-123
23814788-0	2013	Reconstitution of the pyridoxal 5"-phosphate (PLP) dependent enzyme serine palmitoyltransferase (SPT) with pyridoxal reveals a crucial role for the phosphate during catalysis.	Pyridoxal	22-31	pyridoxal phosphatase	Homo sapiens	46-49
21944860-3	2011	In this communication, the inhibitions of the oxidative activity of Cu(II)-Abeta by vitamin B6 compounds pyridoxamine (PM), pyridoxine (PN), pyridoxal (PL), and pyridoxal-5"-phosphate (PLP) are presented.	Pyridoxal	141-150	amyloid beta precursor protein	Homo sapiens	75-80
23510563-1	2013	Carboxylic acid derivatives of pyridoxal were developed as potent P2X(1) and P2X(3) receptor antagonists with modifications of a lead compound, pyridoxal-5"-phosphate-6-azophenyl-2",5"-disulfonate (5b, iso-PPADS).	Pyridoxal	31-40	purinergic receptor P2X 1	Homo sapiens	66-72
24477252-1	2013	Pyridoxal (PL) has been shown to suppress lipopolysaccharide (LPS)-induced gene expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).	Pyridoxal	0-9	prostaglandin-endoperoxide synthase 2	Mus musculus	94-110
24477252-1	2013	Pyridoxal (PL) has been shown to suppress lipopolysaccharide (LPS)-induced gene expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).	Pyridoxal	0-9	prostaglandin-endoperoxide synthase 2	Mus musculus	112-117
24477252-1	2013	Pyridoxal (PL) has been shown to suppress lipopolysaccharide (LPS)-induced gene expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).	Pyridoxal	0-9	nitric oxide synthase 2, inducible	Mus musculus	123-154
24477252-1	2013	Pyridoxal (PL) has been shown to suppress lipopolysaccharide (LPS)-induced gene expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).	Pyridoxal	0-9	nitric oxide synthase 2, inducible	Mus musculus	156-160
24477252-1	2013	Pyridoxal (PL) has been shown to suppress lipopolysaccharide (LPS)-induced gene expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).	Pyridoxal	11-13	prostaglandin-endoperoxide synthase 2	Mus musculus	94-110
24477252-1	2013	Pyridoxal (PL) has been shown to suppress lipopolysaccharide (LPS)-induced gene expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).	Pyridoxal	11-13	prostaglandin-endoperoxide synthase 2	Mus musculus	112-117
24477252-1	2013	Pyridoxal (PL) has been shown to suppress lipopolysaccharide (LPS)-induced gene expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).	Pyridoxal	11-13	nitric oxide synthase 2, inducible	Mus musculus	123-154
24477252-1	2013	Pyridoxal (PL) has been shown to suppress lipopolysaccharide (LPS)-induced gene expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).	Pyridoxal	11-13	nitric oxide synthase 2, inducible	Mus musculus	156-160
22857512-4	2012	Activity of recombinant T. brucei PdxK was comparable to previously published work having a specific activity of 327 +- 13 mU mg(-1) and a K(m)(app) with respect to pyridoxal of 29.6 +- 3.9 microM.	Pyridoxal	165-174	pyridoxal kinase	Homo sapiens	34-38
22879864-3	2012	Pyridoxal (PL), an inactive form of vitamin B6 is converted to PLP by PL kinase.	Pyridoxal	0-9	galectin 1	Homo sapiens	11-13
22879864-3	2012	Pyridoxal (PL), an inactive form of vitamin B6 is converted to PLP by PL kinase.	Pyridoxal	0-9	pyridoxal phosphatase	Homo sapiens	63-66
22879864-3	2012	Pyridoxal (PL), an inactive form of vitamin B6 is converted to PLP by PL kinase.	Pyridoxal	0-9	galectin 1	Homo sapiens	63-65
21944860-3	2011	In this communication, the inhibitions of the oxidative activity of Cu(II)-Abeta by vitamin B6 compounds pyridoxamine (PM), pyridoxine (PN), pyridoxal (PL), and pyridoxal-5"-phosphate (PLP) are presented.	Pyridoxal	152-154	amyloid beta precursor protein	Homo sapiens	75-80
21567949-5	2011	Subsequent LC-MS analysis demonstrated that ZIC-HILIC is useful for the analysis of pyridoxine, pyridoxal and pyridoxal isonicotinoyl hydrazone.	Pyridoxal	96-105	Zic family member 1	Homo sapiens	44-47
21664474-4	2011	The common active form in human tissue is the 5"-phosphate form of pyridoxal (PLP) most of which is found in muscle bound to phosphorylase.	Pyridoxal	67-76	proteolipid protein 1	Homo sapiens	78-81
16273288-3	2005	This study demonstrated that vitamin B6 (pyridoxal) pretreatment of RAW cells inhibited LPS-induced expression of iNOS and COX-2 at the mRNA and protein levels.	Pyridoxal	41-50	nitric oxide synthase 2, inducible	Mus musculus	114-118
21533842-4	2011	Cloning and expression of the AtPLR1 coding region in a yeast mutant deficient for pyridoxal reductase confirmed that the enzyme catalyzes the NADPH-mediated reduction of pyridoxal to pyridoxine.	Pyridoxal	83-92	NAD(P)-linked oxidoreductase superfamily protein	Arabidopsis thaliana	30-36
21533842-8	2011	Analysis of vitamer levels by HPLC showed that both plr1 mutants had lower levels of total vitamin B6, with significantly decreased levels of pyridoxal, pyridoxal 5"-phosphate, pyridoxamine, and pyridoxamine 5"-phosphate.	Pyridoxal	142-151	NAD(P)-linked oxidoreductase superfamily protein	Arabidopsis thaliana	52-56
19351586-1	2009	Pyridoxal kinase catalyzes the phosphorylation of pyridoxal (PL) to pyridoxal 5"-phosphate (PLP).	Pyridoxal	50-59	pyridoxal kinase	Homo sapiens	0-16
19351586-1	2009	Pyridoxal kinase catalyzes the phosphorylation of pyridoxal (PL) to pyridoxal 5"-phosphate (PLP).	Pyridoxal	50-59	pyridoxal phosphatase	Homo sapiens	92-95
19351586-1	2009	Pyridoxal kinase catalyzes the phosphorylation of pyridoxal (PL) to pyridoxal 5"-phosphate (PLP).	Pyridoxal	61-63	pyridoxal kinase	Homo sapiens	0-16
19351586-1	2009	Pyridoxal kinase catalyzes the phosphorylation of pyridoxal (PL) to pyridoxal 5"-phosphate (PLP).	Pyridoxal	61-63	pyridoxal phosphatase	Homo sapiens	92-95
18388403-4	2008	Pyridoxal was completely oxidized to PAL with pyridoxal 4-dehydrogenase (PLDH).	Pyridoxal	0-9	leucine rich repeat, Ig-like and transmembrane domains 1	Homo sapiens	37-40
17707212-1	2007	Pyridoxal kinase (PLK) (EC 2.7.1.35) catalyzes the ATP-dependent phosphorylation of pyridoxal, generating pyridoxal-5.-phosphate (PLP), an important cofactor for many enzymatic reactions.	Pyridoxal	84-93	pyridoxal kinase	Bombyx mori	0-16
17707212-1	2007	Pyridoxal kinase (PLK) (EC 2.7.1.35) catalyzes the ATP-dependent phosphorylation of pyridoxal, generating pyridoxal-5.-phosphate (PLP), an important cofactor for many enzymatic reactions.	Pyridoxal	84-93	pyridoxal kinase	Bombyx mori	18-21
16354669-6	2006	PAO supplemented with benzaldehyde predominantly catalyzed the cleavage of (R)-isomer of alpha-methylspermidine, whereas in the presence of pyridoxal the (S)-alpha-methylspermidine was preferred.	Pyridoxal	140-149	polyamine oxidase	Homo sapiens	0-3
16273288-3	2005	This study demonstrated that vitamin B6 (pyridoxal) pretreatment of RAW cells inhibited LPS-induced expression of iNOS and COX-2 at the mRNA and protein levels.	Pyridoxal	41-50	cytochrome c oxidase II, mitochondrial	Mus musculus	123-128
15985434-1	2005	Pyridoxal kinase (PDXK) catalyzes the phosphorylation of pyridoxal, pyridoxamine, and pyridoxine in the presence of ATP and Zn2+.	Pyridoxal	57-66	pyridoxal kinase	Homo sapiens	0-16
15985434-1	2005	Pyridoxal kinase (PDXK) catalyzes the phosphorylation of pyridoxal, pyridoxamine, and pyridoxine in the presence of ATP and Zn2+.	Pyridoxal	57-66	pyridoxal kinase	Homo sapiens	18-22
15985434-6	2005	Structural analysis revealed that these three roscovitines bind similarly in the pyridoxal-binding site of PDXK rather than in the anticipated ATP-binding site.	Pyridoxal	81-90	pyridoxal kinase	Homo sapiens	107-111
12686105-9	2003	For a long time glutamic acid decarboxylase (GAD), a pyridoxal-dependent enzyme, has been suspected to be the abnormal gene product, but glutamate and gamma-aminobutyric acid (GABA) studies on the cerebrospinal fluid (CSF) have been contradictory and recent genetic studies have not found any linkage to the two brain isoforms.	Pyridoxal	53-62	glutamate decarboxylase 1	Homo sapiens	16-43
14651974-2	2003	PL moderately inhibited only the activities of calf DNA polymerase alpha (pol alpha), while PN and PM had no inhibitory effects on any of the polymerases tested.	Pyridoxal	0-2	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	52-72
14651974-2	2003	PL moderately inhibited only the activities of calf DNA polymerase alpha (pol alpha), while PN and PM had no inhibitory effects on any of the polymerases tested.	Pyridoxal	0-2	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	74-83
14651974-6	2003	Since PL was converted to PLP in vivo after being incorporated into human cancer cells, the anti-angiogenic and anti-cancer effects caused by PL must have been caused by the inhibition of pol alpha and epsilon activities after conversion to PLP.	Pyridoxal	6-8	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	188-197
12792808-1	2003	Recently, the anti-angiogenic effect of pyridoxal 5"-phosphate (PLP) and pyridoxal (PL) was demonstrated in an ex vivo serum-free matrix culture model using rat aortic ring.	Pyridoxal	40-49	pyridoxal phosphatase	Homo sapiens	64-67
15226311-0	2004	Molecular cloning, expression, and properties of an unusual aldo-keto reductase family enzyme, pyridoxal 4-dehydrogenase, that catalyzes irreversible oxidation of pyridoxal.	Pyridoxal	95-104	aldo/keto reductase	Agrobacterium tumefaciens	60-79
12860041-3	2003	A reverse phase HPLC method with pre-column derivatisation using semicarbazide for the simultaneous measurement of PLP, its degradation product, 4-pyridoxic acid (PA) and pyridoxal (PL) in plasma and red cells was developed.	Pyridoxal	17-19	pyridoxal phosphatase	Homo sapiens	115-118
12649274-8	2003	TPN1 mutants lost the ability to utilize extracellular PN, pyridoxal, and pyridoxamine, showing that there is no other transporter for vitamin B6 encoded in the genome.	Pyridoxal	59-68	Tpn1p	Saccharomyces cerevisiae S288C	0-4
12686105-9	2003	For a long time glutamic acid decarboxylase (GAD), a pyridoxal-dependent enzyme, has been suspected to be the abnormal gene product, but glutamate and gamma-aminobutyric acid (GABA) studies on the cerebrospinal fluid (CSF) have been contradictory and recent genetic studies have not found any linkage to the two brain isoforms.	Pyridoxal	53-62	glutamate decarboxylase 1	Homo sapiens	45-48
12686111-1	2003	The pyridoxal-phosphate (PLP)-dependent enzyme alanine:glyoxylate aminotransferase (AGT) is mistargeted from peroxisomes to mitochondria in patients with the hereditary kidney stone disease primary hyperoxaluria type 1 (PH1) due to the synergistic interaction between a common Pro(11)Leu polymorphism and a PH1-specific Gly(170)Arg mutation.	Pyridoxal	4-14	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	47-82
12686111-1	2003	The pyridoxal-phosphate (PLP)-dependent enzyme alanine:glyoxylate aminotransferase (AGT) is mistargeted from peroxisomes to mitochondria in patients with the hereditary kidney stone disease primary hyperoxaluria type 1 (PH1) due to the synergistic interaction between a common Pro(11)Leu polymorphism and a PH1-specific Gly(170)Arg mutation.	Pyridoxal	4-14	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	84-87
12686111-1	2003	The pyridoxal-phosphate (PLP)-dependent enzyme alanine:glyoxylate aminotransferase (AGT) is mistargeted from peroxisomes to mitochondria in patients with the hereditary kidney stone disease primary hyperoxaluria type 1 (PH1) due to the synergistic interaction between a common Pro(11)Leu polymorphism and a PH1-specific Gly(170)Arg mutation.	Pyridoxal	4-14	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	220-223
12686111-1	2003	The pyridoxal-phosphate (PLP)-dependent enzyme alanine:glyoxylate aminotransferase (AGT) is mistargeted from peroxisomes to mitochondria in patients with the hereditary kidney stone disease primary hyperoxaluria type 1 (PH1) due to the synergistic interaction between a common Pro(11)Leu polymorphism and a PH1-specific Gly(170)Arg mutation.	Pyridoxal	4-14	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	307-310
23105165-10	2002	Thus, the residue Lys(280) (6.55), which is located within the upper third of TM 6 of the human P2Y(1) receptor, is not only critical for the activation of the receptor but also plays an important role in the binding of pyridoxal derivatives and a number of other chemically unrelated P2 receptor antagonists.	Pyridoxal	220-229	purinergic receptor P2Y1	Homo sapiens	96-111
10872819-4	2000	Ovalbumin-dependent production of immunoglobulins IgE, IgG1 and interleukin IL-4 was suppressed by administration of medication doses of pyridoxal (PA) or pyridoxine (PI), while the production of IgG2alpha and interferon (INF)-gamma mediated by helper T lymphocyte type 1 was not changed.	Pyridoxal	137-146	interleukin 4	Homo sapiens	76-80
12271675-1	2002	Serine-O-carbonate derivatives, including peptides having a serine-O-carbonate residue at the N-terminal position, are catalytically transformed into S-substituted cysteine derivatives employing the pyridoxal model having an ionophore function in the presence of Li+; this is the first artificial model mimicking cystathionine Beta-synthase.	Pyridoxal	199-208	cystathionine beta-synthase	Homo sapiens	313-340
12068103-10	2002	Consistent with SOS4 function as a PL kinase, in vitro application of pyridoxine and pyridoxamine, but not PL, partially rescued the root hair defect in sos4 mutants.	Pyridoxal	35-37	pfkB-like carbohydrate kinase family protein	Arabidopsis thaliana	16-20
11983425-10	2002	The order of affinity of PK for different analogues is: pyridoxal-oxime>pyridoxine>pyridoxamine>pyridoxal>pyridoxal phosphate.	Pyridoxal	56-65	pyridoxal kinase	Homo sapiens	25-27
10872819-4	2000	Ovalbumin-dependent production of immunoglobulins IgE, IgG1 and interleukin IL-4 was suppressed by administration of medication doses of pyridoxal (PA) or pyridoxine (PI), while the production of IgG2alpha and interferon (INF)-gamma mediated by helper T lymphocyte type 1 was not changed.	Pyridoxal	137-146	interferon gamma	Homo sapiens	210-232
10872819-4	2000	Ovalbumin-dependent production of immunoglobulins IgE, IgG1 and interleukin IL-4 was suppressed by administration of medication doses of pyridoxal (PA) or pyridoxine (PI), while the production of IgG2alpha and interferon (INF)-gamma mediated by helper T lymphocyte type 1 was not changed.	Pyridoxal	148-150	interleukin 4	Homo sapiens	76-80
10872819-4	2000	Ovalbumin-dependent production of immunoglobulins IgE, IgG1 and interleukin IL-4 was suppressed by administration of medication doses of pyridoxal (PA) or pyridoxine (PI), while the production of IgG2alpha and interferon (INF)-gamma mediated by helper T lymphocyte type 1 was not changed.	Pyridoxal	148-150	interferon gamma	Homo sapiens	210-232
10414533-2	1999	This partial cDNA shows 90% identity with mammalian GAD 65 and presents the Asn-Pro-His-Lys (NPHK) sequence corresponding to the pyridoxal-binding region of porcine DOPA decarboxylase or mammalian GAD.	Pyridoxal	129-138	glutamate decarboxylase 2	Homo sapiens	52-58
10575637-5	1999	Transient expression of the GPIIb promoter was determined after transfected cells were treated with 1 microM pyridoxine (PN), pyridoxal (PL), pyridoxal-5-phosphate (PLP), or 4-deoxypyridoxine (4-dex) for 48 h. Our results show that the GPIIb promoter activity was down-regulated to 54, 35 and 63% in the presence of PN, PL and PLP, respectively, as compared to an untreated control whose promoter activity was 100%.	Pyridoxal	126-135	integrin subunit alpha 2b	Homo sapiens	28-33
10575637-5	1999	Transient expression of the GPIIb promoter was determined after transfected cells were treated with 1 microM pyridoxine (PN), pyridoxal (PL), pyridoxal-5-phosphate (PLP), or 4-deoxypyridoxine (4-dex) for 48 h. Our results show that the GPIIb promoter activity was down-regulated to 54, 35 and 63% in the presence of PN, PL and PLP, respectively, as compared to an untreated control whose promoter activity was 100%.	Pyridoxal	137-139	integrin subunit alpha 2b	Homo sapiens	28-33
10414533-2	1999	This partial cDNA shows 90% identity with mammalian GAD 65 and presents the Asn-Pro-His-Lys (NPHK) sequence corresponding to the pyridoxal-binding region of porcine DOPA decarboxylase or mammalian GAD.	Pyridoxal	129-138	dopa decarboxylase	Homo sapiens	165-183
10414533-2	1999	This partial cDNA shows 90% identity with mammalian GAD 65 and presents the Asn-Pro-His-Lys (NPHK) sequence corresponding to the pyridoxal-binding region of porcine DOPA decarboxylase or mammalian GAD.	Pyridoxal	129-138	glutamate decarboxylase 1	Homo sapiens	52-55
10029535-1	1999	The three-dimensional structures of pyridoxal 5"-phosphate-type aspartate aminotransferase (AspAT) from Thermus thermophilus HB8 and pyridoxamine 5"-phosphate type one in complex with maleate have been determined by X-ray crystallography at 1.8 and 2.6 A resolution, respectively.	Pyridoxal	36-45	aspartate/prephenate aminotransferase	Thermus thermophilus HB8	64-90
10029535-1	1999	The three-dimensional structures of pyridoxal 5"-phosphate-type aspartate aminotransferase (AspAT) from Thermus thermophilus HB8 and pyridoxamine 5"-phosphate type one in complex with maleate have been determined by X-ray crystallography at 1.8 and 2.6 A resolution, respectively.	Pyridoxal	36-45	aspartate/prephenate aminotransferase	Thermus thermophilus HB8	92-97