PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
20022989-7	2010	The role of cytochrome P450 epoxygenase (CYP 2C9)-derived endothelium-derived hyperpolarizing factor (EDHF) was assessed by repeating acetylcholine under intraarterial sulfaphenazole.	endothelium-derived hyperpolarizing factor	58-100	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	41-48
18682435-4	2008	We therefore hypothesized that the TRPV4 channel is involved in the flow-induced vasodilatation attributed to the endothelium-derived hyperpolarizing factor (EDHF).	endothelium-derived hyperpolarizing factor	114-156	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	35-40
19289377-6	2009	Endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation via cytochrome P450 metabolites was increased in LOX-1 + FD animals, but did not completely compensate for the loss of NO.	endothelium-derived hyperpolarizing factor	0-42	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	119-124
15016632-1	2004	Blockade of the renin-angiotensin system improves the impaired endothelium-dependent relaxations associated with hypertension and aging, partly through amelioration of endothelium-derived hyperpolarizing factor (EDHF)-mediated responses.	endothelium-derived hyperpolarizing factor	168-210	renin	Rattus norvegicus	16-21
15705930-1	2005	UNLABELLED: Background- We have recently identified that endothelium-derived hydrogen peroxide (H2O2) is an endothelium-derived hyperpolarizing factor (EDHF) in animals and humans, for which endothelial nitric oxide synthase (eNOS) is an important source.	endothelium-derived hyperpolarizing factor	108-150	nitric oxide synthase 3	Homo sapiens	191-224
15749162-1	2005	The perceived importance of C-type natriuretic peptide (CNP) in the mammalian vasculature has been raised by its recent identification as an endothelium-derived hyperpolarizing factor (EDHF).	endothelium-derived hyperpolarizing factor	141-183	natriuretic peptide C	Homo sapiens	28-54
15749162-1	2005	The perceived importance of C-type natriuretic peptide (CNP) in the mammalian vasculature has been raised by its recent identification as an endothelium-derived hyperpolarizing factor (EDHF).	endothelium-derived hyperpolarizing factor	141-183	natriuretic peptide C	Homo sapiens	56-59
15804979-4	2005	VSM KIR participate in dilation induced by elevated extracellular K+ and may also be activated by C-type natriuretic peptide, a putative endothelium-derived hyperpolarizing factor (EDHF).	endothelium-derived hyperpolarizing factor	137-179	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	4-7
15804979-4	2005	VSM KIR participate in dilation induced by elevated extracellular K+ and may also be activated by C-type natriuretic peptide, a putative endothelium-derived hyperpolarizing factor (EDHF).	endothelium-derived hyperpolarizing factor	137-179	natriuretic peptide C	Homo sapiens	98-124
16875977-1	2006	OBJECTIVES: We assessed the role of cytochrome P450 2C9 (CYP 2C9)-derived endothelium-derived hyperpolarizing factor (EDHF) in the forearm microcirculation of essential hypertensive patients (EH) by utilizing sulfaphenazole (SUL), a selective CYP 2C9 inhibitor.	endothelium-derived hyperpolarizing factor	74-116	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	36-55
16875977-1	2006	OBJECTIVES: We assessed the role of cytochrome P450 2C9 (CYP 2C9)-derived endothelium-derived hyperpolarizing factor (EDHF) in the forearm microcirculation of essential hypertensive patients (EH) by utilizing sulfaphenazole (SUL), a selective CYP 2C9 inhibitor.	endothelium-derived hyperpolarizing factor	74-116	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	57-64
16275008-9	2005	In additional similar experiments (n=5), the influence of 1000 KIU/ml aprotinin on the EDR caused by the endothelium-derived hyperpolarizing factor (EDHF) was tested using l-NNA (300 micromol/l) to block all NO formation.	endothelium-derived hyperpolarizing factor	105-147	pancreatic trypsin inhibitor-like	Sus scrofa	70-79
15066907-20	2004	Our results support the concept that bradykinin-induced relaxation is mediated via de novo synthesized NO and a non-NO, endothelium-derived hyperpolarizing factor (EDHF).	endothelium-derived hyperpolarizing factor	120-162	kininogen 1	Homo sapiens	37-47
11179054-1	2001	Endothelium-derived hyperpolarizing factor (EDHF) is released in response to agonists such as ACh and bradykinin and regulates vascular smooth muscle tone.	endothelium-derived hyperpolarizing factor	0-42	kininogen 1	Bos taurus	102-112
12835535-4	2003	In the circulatory system, endothelial PAR-2, upon activation, induces vascular relaxation by mechanisms dependent on nitric oxide or endothelium-derived hyperpolarizing factor (EDHF), resulting in hypotension in vivo.	endothelium-derived hyperpolarizing factor	134-176	F2R like trypsin receptor 1	Homo sapiens	39-44
11040238-1	2000	Angiotensin-converting enzyme (ACE) inhibitor improves the impaired hyperpolarization and relaxation to acetylcholine (ACh) via endothelium-derived hyperpolarizing factor (EDHF) in arteries of spontaneously hypertensive rats (SHR).	endothelium-derived hyperpolarizing factor	128-170	angiotensin I converting enzyme	Rattus norvegicus	0-29
11082118-0	2000	Possible involvement of endothelium-derived hyperpolarizing factor (EDHF) in the depressor responses to platelet activating factor (PAF) in rats.	endothelium-derived hyperpolarizing factor	24-66	PCNA clamp associated factor	Rattus norvegicus	104-130
11082118-0	2000	Possible involvement of endothelium-derived hyperpolarizing factor (EDHF) in the depressor responses to platelet activating factor (PAF) in rats.	endothelium-derived hyperpolarizing factor	24-66	PCNA clamp associated factor	Rattus norvegicus	132-135
11040238-1	2000	Angiotensin-converting enzyme (ACE) inhibitor improves the impaired hyperpolarization and relaxation to acetylcholine (ACh) via endothelium-derived hyperpolarizing factor (EDHF) in arteries of spontaneously hypertensive rats (SHR).	endothelium-derived hyperpolarizing factor	128-170	angiotensin I converting enzyme	Rattus norvegicus	31-34
9784925-10	1998	The endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation to A23187, bradykinin, and substance P in arteries contracted by either U46619 (10 nmol/L) or K+ (25 mmol/L) was reduced after exposure to either high K+ or UW solution, but was maximally preserved after exposure to aprikalim.	endothelium-derived hyperpolarizing factor	4-46	kininogen 1	Homo sapiens	85-95
10856283-1	2000	Bradykinin (BK) stimulates endothelial cells to release a number of relaxing factors, such as NO, prostanoids (PGs), and an endothelium-derived hyperpolarizing factor (EDHF).	endothelium-derived hyperpolarizing factor	124-166	kininogen 1	Homo sapiens	0-10
10856283-1	2000	Bradykinin (BK) stimulates endothelial cells to release a number of relaxing factors, such as NO, prostanoids (PGs), and an endothelium-derived hyperpolarizing factor (EDHF).	endothelium-derived hyperpolarizing factor	124-166	kininogen 1	Homo sapiens	12-14
10511133-1	1999	Although endothelium-derived hyperpolarizing factor (EDHF) is thought to be a cytochrome P-450 product (arachidonic acid metabolite) in some tissues, in porcine coronary arteries (PCAs) its nature remains unclear.	endothelium-derived hyperpolarizing factor	9-51	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	78-94
9784925-10	1998	The endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation to A23187, bradykinin, and substance P in arteries contracted by either U46619 (10 nmol/L) or K+ (25 mmol/L) was reduced after exposure to either high K+ or UW solution, but was maximally preserved after exposure to aprikalim.	endothelium-derived hyperpolarizing factor	4-46	tachykinin precursor 1	Homo sapiens	101-112
9701712-1	1998	An endothelium-derived hyperpolarizing factor (EDHF) mediates a part of the vasodilatory action of bradykinin.	endothelium-derived hyperpolarizing factor	3-45	kininogen 1	Homo sapiens	99-109
7558231-1	1995	In porcine coronary artery endothelium-dependent relaxation to bradykinin is in part attributed to a chemically unidentified factor, termed endothelium-derived hyperpolarizing factor (EDHF).	endothelium-derived hyperpolarizing factor	140-182	kininogen 1	Homo sapiens	63-73
9105709-2	1997	The aim of the present study was to identify the sources of Ca2+ contributing to acetylcholine (ACh)-induced release of endothelium-derived hyperpolarizing factor (EDHF) from endothelial cells of rat mesenteric artery and to assess the pathway involved.	endothelium-derived hyperpolarizing factor	120-162	carbonic anhydrase 2	Rattus norvegicus	60-63
9406662-9	1997	Endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation to A23187, bradykinin, and substance P in the presence of either U46619 (10 nmol/L)- or K+ (25 mmol/L)-induced contraction was reduced after exposure to either 20 or 50 mmol/L K+.	endothelium-derived hyperpolarizing factor	0-42	kininogen 1	Homo sapiens	81-91
9406662-9	1997	Endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation to A23187, bradykinin, and substance P in the presence of either U46619 (10 nmol/L)- or K+ (25 mmol/L)-induced contraction was reduced after exposure to either 20 or 50 mmol/L K+.	endothelium-derived hyperpolarizing factor	0-42	tachykinin precursor 1	Homo sapiens	97-108
8821528-16	1996	Thus, in arteries from exercised animals, bradykinin more potently evoked the release of both nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF).	endothelium-derived hyperpolarizing factor	116-158	kininogen 1	Canis lupus familiaris	42-52
7508046-3	1993	Bradykinin, which is rapidly degraded by ACE, stimulates the release of endothelium-derived vasodilator mediators, including nitric oxide, endothelium-derived hyperpolarizing factor, and prostacyclin.	endothelium-derived hyperpolarizing factor	139-181	kininogen 1	Homo sapiens	0-10
7527103-1	1994	In canine coronary arteries, bradykinin evokes endothelium-dependent relaxations that are mediated by nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF).	endothelium-derived hyperpolarizing factor	124-166	kininogen 1	Canis lupus familiaris	29-39
7508046-3	1993	Bradykinin, which is rapidly degraded by ACE, stimulates the release of endothelium-derived vasodilator mediators, including nitric oxide, endothelium-derived hyperpolarizing factor, and prostacyclin.	endothelium-derived hyperpolarizing factor	139-181	angiotensin I converting enzyme	Homo sapiens	41-44
1548837-2	1992	The hyperpolarizations were resistant to inhibitors of the actions of EDRF, thereby suggesting that they were elicited by an unidentified substance called endothelium-derived hyperpolarizing factor (EDHF).	endothelium-derived hyperpolarizing factor	155-197	alpha hemoglobin stabilizing protein	Homo sapiens	70-74
24816259-8	2014	The BKCa openers, BMS 191011 and NS1619, and 14,15-epoxyeicosatrienoic acid [a putative endothelium-derived hyperpolarizing factor (EDHF)] each caused fetal coronary artery relaxation and BKCa current activation that was unaffected by maternal nutrient restriction.	endothelium-derived hyperpolarizing factor	88-130	Calcium-activated potassium channel subunit alpha-1	Ovis aries	4-8
25765514-8	2015	Among them, Hmox1, Bdkrb2, Adra2b, Ptgs2, Col1a2 and Tbxa2r are associated with endothelium-derived hyperpolarizing factor (EDHF).	endothelium-derived hyperpolarizing factor	80-122	heme oxygenase 1	Homo sapiens	12-17
25765514-8	2015	Among them, Hmox1, Bdkrb2, Adra2b, Ptgs2, Col1a2 and Tbxa2r are associated with endothelium-derived hyperpolarizing factor (EDHF).	endothelium-derived hyperpolarizing factor	80-122	bradykinin receptor B2	Homo sapiens	19-25
25765514-8	2015	Among them, Hmox1, Bdkrb2, Adra2b, Ptgs2, Col1a2 and Tbxa2r are associated with endothelium-derived hyperpolarizing factor (EDHF).	endothelium-derived hyperpolarizing factor	80-122	adrenoceptor alpha 2B	Homo sapiens	27-33
25765514-8	2015	Among them, Hmox1, Bdkrb2, Adra2b, Ptgs2, Col1a2 and Tbxa2r are associated with endothelium-derived hyperpolarizing factor (EDHF).	endothelium-derived hyperpolarizing factor	80-122	prostaglandin-endoperoxide synthase 2	Homo sapiens	35-40
25765514-8	2015	Among them, Hmox1, Bdkrb2, Adra2b, Ptgs2, Col1a2 and Tbxa2r are associated with endothelium-derived hyperpolarizing factor (EDHF).	endothelium-derived hyperpolarizing factor	80-122	collagen type I alpha 2 chain	Homo sapiens	42-48
25765514-8	2015	Among them, Hmox1, Bdkrb2, Adra2b, Ptgs2, Col1a2 and Tbxa2r are associated with endothelium-derived hyperpolarizing factor (EDHF).	endothelium-derived hyperpolarizing factor	80-122	thromboxane A2 receptor	Homo sapiens	53-59
32244050-3	2020	Previously, we showed that PON1 localizes in endothelial cells (ECs), and impairs vasodilation mediated by the endothelium-derived hyperpolarizing factor (EDHF) 5,6-delta-DHTL.	endothelium-derived hyperpolarizing factor	111-153	paraoxonase 1	Homo sapiens	27-31
24816259-8	2014	The BKCa openers, BMS 191011 and NS1619, and 14,15-epoxyeicosatrienoic acid [a putative endothelium-derived hyperpolarizing factor (EDHF)] each caused fetal coronary artery relaxation and BKCa current activation that was unaffected by maternal nutrient restriction.	endothelium-derived hyperpolarizing factor	88-130	Calcium-activated potassium channel subunit alpha-1	Ovis aries	188-192
21973116-3	2012	Under physiological conditions leptin induces endothelium-dependent vasorelaxation by stimulating nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF).	endothelium-derived hyperpolarizing factor	120-162	leptin	Homo sapiens	31-37
21362152-1	2011	AIM: Endothelial membrane hyperpolarization mediated by KCa3.1 and KCa2.3 channels has been demonstrated to initiate endothelium-derived hyperpolarizing factor (EDHF)-type vasodilations.	endothelium-derived hyperpolarizing factor	117-159	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	Mus musculus	56-62
22563439-4	2012	The contribution of endothelium-derived hyperpolarizing factor (EDHF) to endothelium-dependent relaxation was impaired in uremic arteries after stimulation with bradykinin, but not acetylcholine, reflecting the agonist-specific differences.	endothelium-derived hyperpolarizing factor	20-62	kininogen 1	Homo sapiens	161-171
21362152-1	2011	AIM: Endothelial membrane hyperpolarization mediated by KCa3.1 and KCa2.3 channels has been demonstrated to initiate endothelium-derived hyperpolarizing factor (EDHF)-type vasodilations.	endothelium-derived hyperpolarizing factor	117-159	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	Mus musculus	67-73