PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 24816259-8 2014 The BKCa openers, BMS 191011 and NS1619, and 14,15-epoxyeicosatrienoic acid [a putative endothelium-derived hyperpolarizing factor (EDHF)] each caused fetal coronary artery relaxation and BKCa current activation that was unaffected by maternal nutrient restriction. endothelium-derived hyperpolarizing factor 88-130 Calcium-activated potassium channel subunit alpha-1 Ovis aries 4-8 32244050-3 2020 Previously, we showed that PON1 localizes in endothelial cells (ECs), and impairs vasodilation mediated by the endothelium-derived hyperpolarizing factor (EDHF) 5,6-delta-DHTL. endothelium-derived hyperpolarizing factor 111-153 paraoxonase 1 Homo sapiens 27-31 25765514-8 2015 Among them, Hmox1, Bdkrb2, Adra2b, Ptgs2, Col1a2 and Tbxa2r are associated with endothelium-derived hyperpolarizing factor (EDHF). endothelium-derived hyperpolarizing factor 80-122 heme oxygenase 1 Homo sapiens 12-17 25765514-8 2015 Among them, Hmox1, Bdkrb2, Adra2b, Ptgs2, Col1a2 and Tbxa2r are associated with endothelium-derived hyperpolarizing factor (EDHF). endothelium-derived hyperpolarizing factor 80-122 bradykinin receptor B2 Homo sapiens 19-25 25765514-8 2015 Among them, Hmox1, Bdkrb2, Adra2b, Ptgs2, Col1a2 and Tbxa2r are associated with endothelium-derived hyperpolarizing factor (EDHF). endothelium-derived hyperpolarizing factor 80-122 adrenoceptor alpha 2B Homo sapiens 27-33 25765514-8 2015 Among them, Hmox1, Bdkrb2, Adra2b, Ptgs2, Col1a2 and Tbxa2r are associated with endothelium-derived hyperpolarizing factor (EDHF). endothelium-derived hyperpolarizing factor 80-122 prostaglandin-endoperoxide synthase 2 Homo sapiens 35-40 25765514-8 2015 Among them, Hmox1, Bdkrb2, Adra2b, Ptgs2, Col1a2 and Tbxa2r are associated with endothelium-derived hyperpolarizing factor (EDHF). endothelium-derived hyperpolarizing factor 80-122 collagen type I alpha 2 chain Homo sapiens 42-48 25765514-8 2015 Among them, Hmox1, Bdkrb2, Adra2b, Ptgs2, Col1a2 and Tbxa2r are associated with endothelium-derived hyperpolarizing factor (EDHF). endothelium-derived hyperpolarizing factor 80-122 thromboxane A2 receptor Homo sapiens 53-59 24816259-8 2014 The BKCa openers, BMS 191011 and NS1619, and 14,15-epoxyeicosatrienoic acid [a putative endothelium-derived hyperpolarizing factor (EDHF)] each caused fetal coronary artery relaxation and BKCa current activation that was unaffected by maternal nutrient restriction. endothelium-derived hyperpolarizing factor 88-130 Calcium-activated potassium channel subunit alpha-1 Ovis aries 188-192 21362152-1 2011 AIM: Endothelial membrane hyperpolarization mediated by KCa3.1 and KCa2.3 channels has been demonstrated to initiate endothelium-derived hyperpolarizing factor (EDHF)-type vasodilations. endothelium-derived hyperpolarizing factor 117-159 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 Mus musculus 56-62 22563439-4 2012 The contribution of endothelium-derived hyperpolarizing factor (EDHF) to endothelium-dependent relaxation was impaired in uremic arteries after stimulation with bradykinin, but not acetylcholine, reflecting the agonist-specific differences. endothelium-derived hyperpolarizing factor 20-62 kininogen 1 Homo sapiens 161-171 21973116-3 2012 Under physiological conditions leptin induces endothelium-dependent vasorelaxation by stimulating nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF). endothelium-derived hyperpolarizing factor 120-162 leptin Homo sapiens 31-37 21362152-1 2011 AIM: Endothelial membrane hyperpolarization mediated by KCa3.1 and KCa2.3 channels has been demonstrated to initiate endothelium-derived hyperpolarizing factor (EDHF)-type vasodilations. endothelium-derived hyperpolarizing factor 117-159 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 Mus musculus 67-73 20022989-7 2010 The role of cytochrome P450 epoxygenase (CYP 2C9)-derived endothelium-derived hyperpolarizing factor (EDHF) was assessed by repeating acetylcholine under intraarterial sulfaphenazole. endothelium-derived hyperpolarizing factor 58-100 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 41-48 15749162-1 2005 The perceived importance of C-type natriuretic peptide (CNP) in the mammalian vasculature has been raised by its recent identification as an endothelium-derived hyperpolarizing factor (EDHF). endothelium-derived hyperpolarizing factor 141-183 natriuretic peptide C Homo sapiens 28-54 19289377-6 2009 Endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation via cytochrome P450 metabolites was increased in LOX-1 + FD animals, but did not completely compensate for the loss of NO. endothelium-derived hyperpolarizing factor 0-42 oxidized low density lipoprotein (lectin-like) receptor 1 Mus musculus 119-124 18682435-4 2008 We therefore hypothesized that the TRPV4 channel is involved in the flow-induced vasodilatation attributed to the endothelium-derived hyperpolarizing factor (EDHF). endothelium-derived hyperpolarizing factor 114-156 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 35-40 16875977-1 2006 OBJECTIVES: We assessed the role of cytochrome P450 2C9 (CYP 2C9)-derived endothelium-derived hyperpolarizing factor (EDHF) in the forearm microcirculation of essential hypertensive patients (EH) by utilizing sulfaphenazole (SUL), a selective CYP 2C9 inhibitor. endothelium-derived hyperpolarizing factor 74-116 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 36-55 16875977-1 2006 OBJECTIVES: We assessed the role of cytochrome P450 2C9 (CYP 2C9)-derived endothelium-derived hyperpolarizing factor (EDHF) in the forearm microcirculation of essential hypertensive patients (EH) by utilizing sulfaphenazole (SUL), a selective CYP 2C9 inhibitor. endothelium-derived hyperpolarizing factor 74-116 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 57-64 16275008-9 2005 In additional similar experiments (n=5), the influence of 1000 KIU/ml aprotinin on the EDR caused by the endothelium-derived hyperpolarizing factor (EDHF) was tested using l-NNA (300 micromol/l) to block all NO formation. endothelium-derived hyperpolarizing factor 105-147 pancreatic trypsin inhibitor-like Sus scrofa 70-79 15705930-1 2005 UNLABELLED: Background- We have recently identified that endothelium-derived hydrogen peroxide (H2O2) is an endothelium-derived hyperpolarizing factor (EDHF) in animals and humans, for which endothelial nitric oxide synthase (eNOS) is an important source. endothelium-derived hyperpolarizing factor 108-150 nitric oxide synthase 3 Homo sapiens 191-224 15749162-1 2005 The perceived importance of C-type natriuretic peptide (CNP) in the mammalian vasculature has been raised by its recent identification as an endothelium-derived hyperpolarizing factor (EDHF). endothelium-derived hyperpolarizing factor 141-183 natriuretic peptide C Homo sapiens 56-59 15016632-1 2004 Blockade of the renin-angiotensin system improves the impaired endothelium-dependent relaxations associated with hypertension and aging, partly through amelioration of endothelium-derived hyperpolarizing factor (EDHF)-mediated responses. endothelium-derived hyperpolarizing factor 168-210 renin Rattus norvegicus 16-21 15804979-4 2005 VSM KIR participate in dilation induced by elevated extracellular K+ and may also be activated by C-type natriuretic peptide, a putative endothelium-derived hyperpolarizing factor (EDHF). endothelium-derived hyperpolarizing factor 137-179 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 4-7 15804979-4 2005 VSM KIR participate in dilation induced by elevated extracellular K+ and may also be activated by C-type natriuretic peptide, a putative endothelium-derived hyperpolarizing factor (EDHF). endothelium-derived hyperpolarizing factor 137-179 natriuretic peptide C Homo sapiens 98-124 11082118-0 2000 Possible involvement of endothelium-derived hyperpolarizing factor (EDHF) in the depressor responses to platelet activating factor (PAF) in rats. endothelium-derived hyperpolarizing factor 24-66 PCNA clamp associated factor Rattus norvegicus 104-130 12835535-4 2003 In the circulatory system, endothelial PAR-2, upon activation, induces vascular relaxation by mechanisms dependent on nitric oxide or endothelium-derived hyperpolarizing factor (EDHF), resulting in hypotension in vivo. endothelium-derived hyperpolarizing factor 134-176 F2R like trypsin receptor 1 Homo sapiens 39-44 15066907-20 2004 Our results support the concept that bradykinin-induced relaxation is mediated via de novo synthesized NO and a non-NO, endothelium-derived hyperpolarizing factor (EDHF). endothelium-derived hyperpolarizing factor 120-162 kininogen 1 Homo sapiens 37-47 11179054-1 2001 Endothelium-derived hyperpolarizing factor (EDHF) is released in response to agonists such as ACh and bradykinin and regulates vascular smooth muscle tone. endothelium-derived hyperpolarizing factor 0-42 kininogen 1 Bos taurus 102-112 11082118-0 2000 Possible involvement of endothelium-derived hyperpolarizing factor (EDHF) in the depressor responses to platelet activating factor (PAF) in rats. endothelium-derived hyperpolarizing factor 24-66 PCNA clamp associated factor Rattus norvegicus 132-135 9406662-9 1997 Endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation to A23187, bradykinin, and substance P in the presence of either U46619 (10 nmol/L)- or K+ (25 mmol/L)-induced contraction was reduced after exposure to either 20 or 50 mmol/L K+. endothelium-derived hyperpolarizing factor 0-42 kininogen 1 Homo sapiens 81-91 10511133-1 1999 Although endothelium-derived hyperpolarizing factor (EDHF) is thought to be a cytochrome P-450 product (arachidonic acid metabolite) in some tissues, in porcine coronary arteries (PCAs) its nature remains unclear. endothelium-derived hyperpolarizing factor 9-51 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 78-94 11040238-1 2000 Angiotensin-converting enzyme (ACE) inhibitor improves the impaired hyperpolarization and relaxation to acetylcholine (ACh) via endothelium-derived hyperpolarizing factor (EDHF) in arteries of spontaneously hypertensive rats (SHR). endothelium-derived hyperpolarizing factor 128-170 angiotensin I converting enzyme Rattus norvegicus 0-29 11040238-1 2000 Angiotensin-converting enzyme (ACE) inhibitor improves the impaired hyperpolarization and relaxation to acetylcholine (ACh) via endothelium-derived hyperpolarizing factor (EDHF) in arteries of spontaneously hypertensive rats (SHR). endothelium-derived hyperpolarizing factor 128-170 angiotensin I converting enzyme Rattus norvegicus 31-34 10856283-1 2000 Bradykinin (BK) stimulates endothelial cells to release a number of relaxing factors, such as NO, prostanoids (PGs), and an endothelium-derived hyperpolarizing factor (EDHF). endothelium-derived hyperpolarizing factor 124-166 kininogen 1 Homo sapiens 0-10 10856283-1 2000 Bradykinin (BK) stimulates endothelial cells to release a number of relaxing factors, such as NO, prostanoids (PGs), and an endothelium-derived hyperpolarizing factor (EDHF). endothelium-derived hyperpolarizing factor 124-166 kininogen 1 Homo sapiens 12-14 9784925-10 1998 The endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation to A23187, bradykinin, and substance P in arteries contracted by either U46619 (10 nmol/L) or K+ (25 mmol/L) was reduced after exposure to either high K+ or UW solution, but was maximally preserved after exposure to aprikalim. endothelium-derived hyperpolarizing factor 4-46 kininogen 1 Homo sapiens 85-95 9784925-10 1998 The endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation to A23187, bradykinin, and substance P in arteries contracted by either U46619 (10 nmol/L) or K+ (25 mmol/L) was reduced after exposure to either high K+ or UW solution, but was maximally preserved after exposure to aprikalim. endothelium-derived hyperpolarizing factor 4-46 tachykinin precursor 1 Homo sapiens 101-112 9701712-1 1998 An endothelium-derived hyperpolarizing factor (EDHF) mediates a part of the vasodilatory action of bradykinin. endothelium-derived hyperpolarizing factor 3-45 kininogen 1 Homo sapiens 99-109 9406662-9 1997 Endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation to A23187, bradykinin, and substance P in the presence of either U46619 (10 nmol/L)- or K+ (25 mmol/L)-induced contraction was reduced after exposure to either 20 or 50 mmol/L K+. endothelium-derived hyperpolarizing factor 0-42 tachykinin precursor 1 Homo sapiens 97-108 9105709-2 1997 The aim of the present study was to identify the sources of Ca2+ contributing to acetylcholine (ACh)-induced release of endothelium-derived hyperpolarizing factor (EDHF) from endothelial cells of rat mesenteric artery and to assess the pathway involved. endothelium-derived hyperpolarizing factor 120-162 carbonic anhydrase 2 Rattus norvegicus 60-63 7558231-1 1995 In porcine coronary artery endothelium-dependent relaxation to bradykinin is in part attributed to a chemically unidentified factor, termed endothelium-derived hyperpolarizing factor (EDHF). endothelium-derived hyperpolarizing factor 140-182 kininogen 1 Homo sapiens 63-73 8821528-16 1996 Thus, in arteries from exercised animals, bradykinin more potently evoked the release of both nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF). endothelium-derived hyperpolarizing factor 116-158 kininogen 1 Canis lupus familiaris 42-52 7508046-3 1993 Bradykinin, which is rapidly degraded by ACE, stimulates the release of endothelium-derived vasodilator mediators, including nitric oxide, endothelium-derived hyperpolarizing factor, and prostacyclin. endothelium-derived hyperpolarizing factor 139-181 kininogen 1 Homo sapiens 0-10 7527103-1 1994 In canine coronary arteries, bradykinin evokes endothelium-dependent relaxations that are mediated by nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF). endothelium-derived hyperpolarizing factor 124-166 kininogen 1 Canis lupus familiaris 29-39 7508046-3 1993 Bradykinin, which is rapidly degraded by ACE, stimulates the release of endothelium-derived vasodilator mediators, including nitric oxide, endothelium-derived hyperpolarizing factor, and prostacyclin. endothelium-derived hyperpolarizing factor 139-181 angiotensin I converting enzyme Homo sapiens 41-44 1548837-2 1992 The hyperpolarizations were resistant to inhibitors of the actions of EDRF, thereby suggesting that they were elicited by an unidentified substance called endothelium-derived hyperpolarizing factor (EDHF). endothelium-derived hyperpolarizing factor 155-197 alpha hemoglobin stabilizing protein Homo sapiens 70-74