PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2492810-2	1989	The endogenous material (F-1 and F-2) obtained after Bio-Gel P-2 gel filtration and silica column chromatography inhibited MAO in the monkey brain mitochondria toward 5-hydroxytryptamine (5-HT), beta-phenylethylamine (beta-PEA), tyramine and dopamine as substrates.	phenethylamine	195-216	coagulation factor II, thrombin	Homo sapiens	25-36
2492810-2	1989	The endogenous material (F-1 and F-2) obtained after Bio-Gel P-2 gel filtration and silica column chromatography inhibited MAO in the monkey brain mitochondria toward 5-hydroxytryptamine (5-HT), beta-phenylethylamine (beta-PEA), tyramine and dopamine as substrates.	phenethylamine	218-226	coagulation factor II, thrombin	Homo sapiens	25-36
3409624-7	1988	Non-specific N-methyltransferase activity was estimated in 17 of the surgical specimens using beta-phenylethylamine as substrate.	phenethylamine	94-115	N-myristoyltransferase 1	Homo sapiens	13-32
3149722-7	1988	In the latter condition, the concentrations of beta-phenylethylamine remained at control values due to the activity of monoamine oxidase B.	phenethylamine	47-68	monoamine oxidase B	Mus musculus	119-138
2924086-4	1989	The results demonstrated the presence of MAO A and B in human thyroid cells which oxidized 5-hydroxytryptamine and 2-phenylethylamine, respectively, and were selectively inhibited by the MAO inhibitors clorgyline and (-)-deprenyl.	phenethylamine	115-133	monoamine oxidase A	Homo sapiens	41-52
2622533-3	1989	While dopaminergic neurons of the substantia nigra revealed no staining for monoamine oxidase, noradrenergic neurons of the locus coeruleus stained positively with the monoamine oxidase-A substrate serotonin, and serotonergic neurons of the raphe nuclei were stained by the monoamine oxidase-B substrate beta-phenylethylamine.	phenethylamine	304-325	monoamine oxidase A	Homo sapiens	168-187
3742029-2	1986	Distinct effects of these compounds on the deamination of serotonin and norepinephrine (MAO-A substrates); 2-phenylethylamine (selective MAO-B substrate); tyramine and dopamine (MAO-A and MAO-B substrates) are shown.	phenethylamine	107-125	monoamine oxidase B	Rattus norvegicus	137-142
3134400-8	1988	14CO2 was trapped quantitatively using phenethylamine.	phenethylamine	39-53	complement C2	Homo sapiens	2-5
3681890-7	1987	The results of this study are in agreement with previous findings for bound beta-phenylethylamines and support the conclusion that the natural substrate for PNMT, norepinephrine, has a different active site binding orientation than most known substrates and competitive inhibitors of the enzyme.	phenethylamine	76-98	phenylethanolamine N-methyltransferase	Homo sapiens	157-161
3125369-2	1987	Monoamine oxidase (MAO) activities in the heart, lung and liver mitochondria decreased rapidly to about 50% those of the control rats with 5-HT and beta-phenylethylamine (beta-PEA) as substrates on the first day.	phenethylamine	148-169	monoamine oxidase A	Rattus norvegicus	0-17
3125369-2	1987	Monoamine oxidase (MAO) activities in the heart, lung and liver mitochondria decreased rapidly to about 50% those of the control rats with 5-HT and beta-phenylethylamine (beta-PEA) as substrates on the first day.	phenethylamine	148-169	monoamine oxidase A	Rattus norvegicus	19-22
3125369-2	1987	Monoamine oxidase (MAO) activities in the heart, lung and liver mitochondria decreased rapidly to about 50% those of the control rats with 5-HT and beta-phenylethylamine (beta-PEA) as substrates on the first day.	phenethylamine	171-179	monoamine oxidase A	Rattus norvegicus	0-17
3125369-2	1987	Monoamine oxidase (MAO) activities in the heart, lung and liver mitochondria decreased rapidly to about 50% those of the control rats with 5-HT and beta-phenylethylamine (beta-PEA) as substrates on the first day.	phenethylamine	171-179	monoamine oxidase A	Rattus norvegicus	19-22
3125369-9	1987	MAO activities in liver also were inhibited by adding all the cytosols when beta-PEA was the substrate, but on the contrary, lung MAO activities were increased when 5-HT was the substrate.	phenethylamine	76-84	monoamine oxidase A	Rattus norvegicus	0-3
3114816-1	1987	Beta-phenylethylamine (PEA) is an endogenous amine which is metabolised by MAO B.	phenethylamine	0-21	monoamine oxidase B	Rattus norvegicus	75-80
3114816-1	1987	Beta-phenylethylamine (PEA) is an endogenous amine which is metabolised by MAO B.	phenethylamine	23-26	monoamine oxidase B	Rattus norvegicus	75-80
3681889-0	1987	Binding orientation of amphetamine and norfenfluramine analogues in the benzonorbornene and benzobicyclo[3.2.1]octane ring systems at the active site of phenylethanolamine N-methyltransferase (PNMT) In a continuation of studies directed at characterizing the conformational basis of binding beta-phenylethylamines at the active site of phenylethanolamine N-methyltransferase (PNMT), anti-10-amino- (12) and syn-10-amino-5,6,7,8-tetrahydro-5,8-methano-9H-benzocycloheptene (13) were prepared and evaluated as substrates and inhibitors for PNMT.	phenethylamine	291-313	phenylethanolamine N-methyltransferase	Homo sapiens	153-191
3118881-0	1987	[13N]-beta-phenethylamine ([13N]PEA): a prototype tracer for measurement of MAO-B activity in heart.	phenethylamine	6-25	monoamine oxidase B	Homo sapiens	76-81
3627289-3	1987	administration of N-propargyl-2-phenylethylamine produced marked elevations in 2-phenylethylamine levels in rat brain, blood and liver; these levels remained significantly above controls for more than 4 h. Neurochemical studies showed the drug to be a preferential MAO-B inhibitor at a dose of 0.1 mmol/kg (i.p.).	phenethylamine	30-48	monoamine oxidase B	Rattus norvegicus	265-270
3116977-7	1987	Significantly lower MAO B activities were observed in hypertensive patients both in men (19.25 +/- 2.20, n = 8 versus 24.35 +/- 2.22, n = 14, desaminated beta-phenyl-ethylamine/10(9) platelets/hour, x +/- SEM, p less than 0.05) and in women (23.92 +/- 2.74, n = 10 versus 35.76 +/- 2.35, n = 21, p less than 0.01) when compared to normotensive controls of the same sex.	phenethylamine	154-176	monoamine oxidase B	Homo sapiens	20-25
3783606-4	1986	These inhibitors incorporate structural features that resemble both tyramine and oxygen substrates, and as evidenced by steady-state kinetics, they appear to bind both the phenethylamine binding site and the active site copper atom(s) in DBH.	phenethylamine	172-186	dopamine beta-hydroxylase	Homo sapiens	238-241
3961266-3	1986	PPA was found to inhibit both human brain and rat liver mitochondrial MAO activities in vitro, i.e. Ki"s were 150 microM and 800 microM with respect to serotonin (Type A substrate) and beta-phenylethylamine (Type B substrate).	phenethylamine	185-206	monoamine oxidase A	Rattus norvegicus	70-73
3090452-1	1986	Both the MAO-B inhibitor deprenyl (2.5-10 mg/kg, ip, 60 min prior) and the MAO-B substrate beta-phenylethylamine (PEA, 40 micrograms, icv) potentiated the analgesic action of the enkephalinase inhibitor phosphoramidon (250 micrograms, icv) in animals allowed normal sleep.	phenethylamine	91-112	monoamine oxidase B	Rattus norvegicus	75-80
3714772-0	1986	beta-phenylethylamine effect on brain and blood catechol-O-methyltransferase activity.	phenethylamine	0-21	catechol-O-methyltransferase	Homo sapiens	48-76
3714772-1	1986	A significant decrease in catechol-o-methyltransferase (COMT) activity has been found in the striatum (77% of control) and hippocampus (63% of control) of gerbils treated with daily injections of beta-phenylethylamine (50 mg/kg) for 10 days.	phenethylamine	196-217	catechol-O-methyltransferase	Homo sapiens	26-54
3714772-1	1986	A significant decrease in catechol-o-methyltransferase (COMT) activity has been found in the striatum (77% of control) and hippocampus (63% of control) of gerbils treated with daily injections of beta-phenylethylamine (50 mg/kg) for 10 days.	phenethylamine	196-217	catechol-O-methyltransferase	Homo sapiens	56-60
3953019-1	1986	Activity of monoamine oxidases (MAO) of the types A and B (substrates: 5-hydroxytryptamine, 2-phenylethylamine, tyramine) has been studied in mitochondrial fractions from brain, heart, liver and kidney of 24-week-old rats of the normotonic strain Wistar Kyoto (WKY) and spontaneously hypertonic rats (SHR).	phenethylamine	92-110	monoamine oxidase A	Rattus norvegicus	12-30
3953019-1	1986	Activity of monoamine oxidases (MAO) of the types A and B (substrates: 5-hydroxytryptamine, 2-phenylethylamine, tyramine) has been studied in mitochondrial fractions from brain, heart, liver and kidney of 24-week-old rats of the normotonic strain Wistar Kyoto (WKY) and spontaneously hypertonic rats (SHR).	phenethylamine	92-110	monoamine oxidase A	Rattus norvegicus	32-35
3953019-5	1986	In kidney mitochondria of SHR the activity of MAO (substrates: 5-hydroxytryptamine, 2-phenylethylamine, tyramine) did not exhibit any alterations as compared with the control WKY rats.	phenethylamine	84-102	monoamine oxidase A	Rattus norvegicus	46-49
3999819-4	1985	beta-Phenylethylamine is a good substrate for monoamine oxidase type B but also for the soluble clorgyline-deprenyl-resistant benzylamine oxidase.	phenethylamine	0-21	amine oxidase [flavin-containing] B	Cavia porcellus	46-70
3999927-6	1985	Although a high microvessel MAO activity (2.2 +/- 0.3 nmol min-1 mg prot.-1) was found using noradrenaline as substrate, significantly higher rates were found with tyramine, serotonin and beta-phenyl-ethylamine.	phenethylamine	188-210	monoamine oxidase A	Rattus norvegicus	28-31
3928010-2	1985	Both selective MAO-A and MAO-B inhibitors markedly potentiated nictitating membrane contractions in response to beta-phenylethylamine (PEA).	phenethylamine	112-133	monoamine oxidase A	Homo sapiens	15-20
3928010-2	1985	Both selective MAO-A and MAO-B inhibitors markedly potentiated nictitating membrane contractions in response to beta-phenylethylamine (PEA).	phenethylamine	112-133	monoamine oxidase B	Homo sapiens	25-30
3928010-2	1985	Both selective MAO-A and MAO-B inhibitors markedly potentiated nictitating membrane contractions in response to beta-phenylethylamine (PEA).	phenethylamine	135-138	monoamine oxidase A	Homo sapiens	15-20
3928010-2	1985	Both selective MAO-A and MAO-B inhibitors markedly potentiated nictitating membrane contractions in response to beta-phenylethylamine (PEA).	phenethylamine	135-138	monoamine oxidase B	Homo sapiens	25-30
3835805-1	1985	In experiments on male Wistar albino rats was studied the effect of Co, Cd, Ni, Zn, Hg and Pb on the activity of rat liver and brain monoamine oxidase (MAO) using tyramine, serotonin and beta-phenylethylamine as substrates.	phenethylamine	187-208	monoamine oxidase A	Rattus norvegicus	133-150
3835805-1	1985	In experiments on male Wistar albino rats was studied the effect of Co, Cd, Ni, Zn, Hg and Pb on the activity of rat liver and brain monoamine oxidase (MAO) using tyramine, serotonin and beta-phenylethylamine as substrates.	phenethylamine	187-208	monoamine oxidase A	Rattus norvegicus	152-155
4016256-3	1985	The enzyme contains 2 SH-groups per 10(5) daltons of protein and deaminates MAO substrates (serotonin, beta-phenylethylamine) along with histamine, diamine oxidase substrate.	phenethylamine	103-124	amine oxidase copper containing 1	Homo sapiens	148-163
4036650-5	1985	Monoamine oxidase B (substrate beta-phenylethylamine) develops after the 10th postnatal day.	phenethylamine	31-52	monoamine oxidase B	Rattus norvegicus	0-19
3833630-3	1985	On the other hand, beta-phenylethylamine, a specific substrate for MAO B used as a substrate, showed no significant difference between the alcoholic and control groups in the activities.	phenethylamine	19-40	monoamine oxidase B	Homo sapiens	67-72
6625963-4	1983	The increase in MAO activity could be explained by the observed significant decrease in apparent Km values for the amine (phenethylamine) studied.	phenethylamine	122-136	monoamine oxidase A	Rattus norvegicus	16-19
6436886-1	1984	Stereotyped sniffing behavior together with forepaw padding--defined as the beta-phenylethylamine (PEA) syndrome--is induced by MAO-B inhibitors in rats injected with 30 mg/kg IP PEA.	phenethylamine	76-97	monoamine oxidase B	Rattus norvegicus	128-133
6436886-1	1984	Stereotyped sniffing behavior together with forepaw padding--defined as the beta-phenylethylamine (PEA) syndrome--is induced by MAO-B inhibitors in rats injected with 30 mg/kg IP PEA.	phenethylamine	99-102	monoamine oxidase B	Rattus norvegicus	128-133
6649522-3	1983	In human placenta and rat heart containing only the type A MAO, which catalyzes deamination of 2-phenylethylamine, pyrazidol also inhibited the deamination of serotonin, tyramine and 2-phenylethylamine at comparatively low concentrations and in equal degree.	phenethylamine	95-113	monoamine oxidase A	Rattus norvegicus	59-62
6518192-1	1984	The values of Km and V for serotonin, tyramine and beta-phenylethylamine deamination by solubilized and partially purified preparations of monoamine oxidase (MAO) from rat liver were determined.	phenethylamine	51-72	monoamine oxidase A	Rattus norvegicus	139-156
6518192-1	1984	The values of Km and V for serotonin, tyramine and beta-phenylethylamine deamination by solubilized and partially purified preparations of monoamine oxidase (MAO) from rat liver were determined.	phenethylamine	51-72	monoamine oxidase A	Rattus norvegicus	158-161
6748374-3	1984	The selective and potent MAO-A and MAO-B inhibitors FLA 788(+), FLA 336(+), MD 780236 and benzylcyanide caused dose-dependent inhibitions of MAO activity in both carp brain and liver; the inhibition curves were all single-sigmoidal, and the degrees of inhibition of the activities towards 5-hydroxytryptamine (5-HT, selective MAO-A substrate), tyramine (substrate for both forms of MAO) and beta-phenylethylamine (PEA, selective MAO-B substrate) were similar.	phenethylamine	391-412	monoamine oxidase B	Rattus norvegicus	35-40
6741571-3	1984	The increase in MAO activity in the presence of human plasma can be explained by the observed decrease in the apparent Km for the amine (tyramine, PEA).	phenethylamine	147-150	monoamine oxidase A	Rattus norvegicus	16-19
7056361-1	1982	The activities of monoamine oxidases A and B towards 5-hydroxytryptamine and beta-phenethylamine, respectively, were compared in the left and right caudatus, hippocampus, parietal cortex, cerebellum and frontal cortex 6 months after gamma-irradiation (single dose of 23 Gy) of either the right hemisphere or of the whole rabbit brain (in which case, a dose of l6 Gy).	phenethylamine	77-96	amine oxidase [flavin-containing] A	Oryctolagus cuniculus	18-44
6401800-9	1983	H2O2 generated by deamination of NA or PEA by MAO, or during the enzymatic oxidation of glucose by GOD, caused a threefold increase in mitochondrial endoperoxide formation.	phenethylamine	39-42	monoamine oxidase A	Rattus norvegicus	46-49
6884911-1	1983	The inhibiting effect of monoamine oxidase (MAO) activities towards 5-hydroxytryptamine, dopamine and beta-phenylethylamine by an acute and chronic administration of clorgyline was investigated in five locations of the rat brain.	phenethylamine	102-123	monoamine oxidase A	Rattus norvegicus	25-42
6884911-1	1983	The inhibiting effect of monoamine oxidase (MAO) activities towards 5-hydroxytryptamine, dopamine and beta-phenylethylamine by an acute and chronic administration of clorgyline was investigated in five locations of the rat brain.	phenethylamine	102-123	monoamine oxidase A	Rattus norvegicus	44-47
6884911-3	1983	A significant percentage of inhibition for type B MAO towards beta-phenylethylamine was noticed in the chronically administered group.	phenethylamine	62-83	monoamine oxidase A	Rattus norvegicus	50-53
7080482-8	1982	Controlled heating experiments indicated higher thermostability of MAO type B (substrate: 2-phenylethylamine) as compared with MAO type A (substrate: serotonin) in rat intestinal mitochondria.	phenethylamine	90-108	monoamine oxidase A	Rattus norvegicus	67-70
6652339-1	1983	In vivo clorgyline (5 mg/kg) and (-)-deprenyl (5 mg/kg) selectively inhibit monoamine oxidase (MAO) type A and B activities in rat brain hypothalamus and caudate nucleus using 5-hydroxytryptamine (5-HT), noradrenaline (NA), and beta-phenylethylamine (PEA) as substrates.	phenethylamine	228-249	monoamine oxidase A	Rattus norvegicus	76-112
6652339-1	1983	In vivo clorgyline (5 mg/kg) and (-)-deprenyl (5 mg/kg) selectively inhibit monoamine oxidase (MAO) type A and B activities in rat brain hypothalamus and caudate nucleus using 5-hydroxytryptamine (5-HT), noradrenaline (NA), and beta-phenylethylamine (PEA) as substrates.	phenethylamine	251-254	monoamine oxidase A	Rattus norvegicus	76-112
6406646-4	1983	The activity of MAO-B was higher in the old rats, the degree of increase being the same for dopamine as for beta-phenethylamine as substrates for this enzyme form.	phenethylamine	108-127	monoamine oxidase B	Rattus norvegicus	16-21
7173310-4	1982	Rapid synthesis of p-TA and m-TA resulted in increased acid concentrations at 4 h. HVA concentrations were increased up to 1 h after PE administration.	phenethylamine	133-135	pre T cell antigen receptor alpha	Mus musculus	19-23
7173310-6	1982	PE may serve as a precursor for p-TA synthesis when the endogenous PE concentration is greatly elevated.	phenethylamine	0-2	pre T cell antigen receptor alpha	Mus musculus	32-36
7173310-6	1982	PE may serve as a precursor for p-TA synthesis when the endogenous PE concentration is greatly elevated.	phenethylamine	67-69	pre T cell antigen receptor alpha	Mus musculus	32-36
6807318-3	1982	In contrast, B-form MAO activity decreased rapidly and the level of MAO activity was maintained at about 30% with beta-phenylethylamine (beta-PEA) as substrate.	phenethylamine	114-135	monoamine oxidase A	Rattus norvegicus	20-23
6807318-3	1982	In contrast, B-form MAO activity decreased rapidly and the level of MAO activity was maintained at about 30% with beta-phenylethylamine (beta-PEA) as substrate.	phenethylamine	114-135	monoamine oxidase A	Rattus norvegicus	68-71
6807318-3	1982	In contrast, B-form MAO activity decreased rapidly and the level of MAO activity was maintained at about 30% with beta-phenylethylamine (beta-PEA) as substrate.	phenethylamine	137-145	monoamine oxidase A	Rattus norvegicus	20-23
6807318-3	1982	In contrast, B-form MAO activity decreased rapidly and the level of MAO activity was maintained at about 30% with beta-phenylethylamine (beta-PEA) as substrate.	phenethylamine	137-145	monoamine oxidase A	Rattus norvegicus	68-71
7086649-0	1982	Phenethylamine inhibitors of partially purified rat and human pancreatic lipase.	phenethylamine	0-14	pancreatic lipase	Homo sapiens	62-79
7086649-3	1982	Several compounds of the phenethylamine class were found to be inhibitors of both rat and human pancreatic lipase.	phenethylamine	25-39	pancreatic lipase	Homo sapiens	96-113
7057191-5	1982	The Ki for 5-hydroxytryptamine as a competitive inhibitor of beta-phenethylamine oxidation by MAO-B was found to be 1400 microM.	phenethylamine	61-80	monoamine oxidase B	Rattus norvegicus	94-99
7264651-1	1981	The inhibiton of type A and B MAO in rat forebrain crude membrane preparation by MD780515, (3-(4-[(3-cyanophenyl)methoxy]phenyl)-5-(methoxymethyl)-2-oxazolidinone-Centre de Recherche Delalande, France) has been investigated in vitro with 5-hydroxytryptamine and beta-phenylethylamine as substrates.	phenethylamine	262-283	monoamine oxidase A	Rattus norvegicus	30-33
6797482-3	1981	After solubilization of MAO by methylethylketone 7% of mitochondrial activity passes into solution and the rate of deamination of serotonin, tyramine and beta-phenylethylamine by soluble MAO preparation is selectively decreased.	phenethylamine	154-175	monoamine oxidase A	Rattus norvegicus	24-27
6797482-3	1981	After solubilization of MAO by methylethylketone 7% of mitochondrial activity passes into solution and the rate of deamination of serotonin, tyramine and beta-phenylethylamine by soluble MAO preparation is selectively decreased.	phenethylamine	154-175	monoamine oxidase A	Rattus norvegicus	187-190
6797482-8	1981	The rate of inhibition by deprenyl of beta-phenylethylamine oxidation due to MAO solubilization by methylethylketone is not changed.	phenethylamine	38-59	monoamine oxidase A	Rattus norvegicus	77-80
7279004-3	1981	The monoamine oxidase-B activity towards beta-phenethylamine increased in the left side striatum to a significant level by 3 days, and in the hemispheres and occipito-temporal cortex on the left side, with respect to the right side by 9 days, but no significant changes were found for the limbic system.	phenethylamine	41-60	monoamine oxidase B	Rattus norvegicus	4-23
7205271-1	1981	beta-Phenylethylamine (PEA) was characterized as a substrate for type A and type B monoamine oxidase (MAO) in brain and liver mitochondria of eight species at different substrate concentrations.	phenethylamine	0-21	monoamine oxidase A	Rattus norvegicus	102-105
7205271-1	1981	beta-Phenylethylamine (PEA) was characterized as a substrate for type A and type B monoamine oxidase (MAO) in brain and liver mitochondria of eight species at different substrate concentrations.	phenethylamine	23-26	monoamine oxidase A	Rattus norvegicus	102-105
7052551-1	1980	The activities of monoamine oxidase (MAO)-A and MAO-B (using [3H]serotonin and [14C]beta-phenylethylamine, respectively, as substrates) were determined in homogenates of whole mouse brains using a solvent extraction procedure.	phenethylamine	84-105	monoamine oxidase A	Mus musculus	18-43
7219870-1	1981	The activities of monoamine oxidase (MAO)-A and -B in subcellular fractions of bovine retina were determined using serotonin and beta-phenylethylamine, respectively, as substrates.	phenethylamine	129-150	monoamine oxidase A	Bos taurus	18-50
7052551-1	1980	The activities of monoamine oxidase (MAO)-A and MAO-B (using [3H]serotonin and [14C]beta-phenylethylamine, respectively, as substrates) were determined in homogenates of whole mouse brains using a solvent extraction procedure.	phenethylamine	84-105	monoamine oxidase B	Mus musculus	48-53
6107935-0	1980	Evidence that a preferred substrate for type B monoamine oxidase mediates stimulus properties of MAO inhibitors: a possible role for beta-phenylethylamine in the cocaine cue.	phenethylamine	133-154	monoamine oxidase A	Rattus norvegicus	97-100
7422056-2	1980	It was found that the concentration of monoamine oxidase-B determined in this way was the same when either benzylamine or beta-phenethylamine was used to assay for activity, which would indicate that this enzyme form is not heterogeneous.	phenethylamine	122-141	monoamine oxidase B	Homo sapiens	39-58
32944-1	1979	1 Metabolism of 5-hydroxytryptamine (5-HT) and beta-phenylethylamine (PHE) by monoamine oxidase (MAO) was investigated in rat isolated lungs and in mitochondrial preparations from rat lung.	phenethylamine	47-68	monoamine oxidase A	Rattus norvegicus	78-95
20227955-0	1980	Beta-phenylethylamine and benzylamine as substrates for human monoamine oxidase A: A source of some anomalies?	phenethylamine	0-21	monoamine oxidase A	Homo sapiens	62-81
435561-1	1979	The inhibition of the deamination of serotonin (the main substrate of monoamine oxidase (MAO) type A) by chlorgiline and deprenyl and of beta-phenylethylamine (the main substrate of the B type MAO) by fragments of rat liver mitochondrial membrane as well as the influence of 4-ethylpyridine on this process were studied.	phenethylamine	137-158	monoamine oxidase A	Rattus norvegicus	89-92
435561-2	1979	It was shown that the MAO activity of the mitochondrial membrane fragments was highly sensitive to chlorgiline, when serotonin was used as substrate, whereas a high sensitivity toward deprenyl was observed with beta-phenylethylamine as substrate.	phenethylamine	211-232	monoamine oxidase A	Rattus norvegicus	22-25
435561-3	1979	4-Ethylpyridine (5.10(-3) M), a competitive and reversible inhibitor of the MAO activity, inhibited deamination of serotonin and beta-phenylethylamine by 34 and 30%, respectively.	phenethylamine	129-150	monoamine oxidase A	Rattus norvegicus	76-79
574038-1	1979	1 Metabolism of [14C]-beta-phenylethylamine (PEN), a substrate for monoamine oxidase-B (MAO-B), was measured in lung homogenates and in perfused lungs during the 4 day oestrous cycle of the rat.	phenethylamine	45-48	monoamine oxidase B	Rattus norvegicus	67-86
574038-1	1979	1 Metabolism of [14C]-beta-phenylethylamine (PEN), a substrate for monoamine oxidase-B (MAO-B), was measured in lung homogenates and in perfused lungs during the 4 day oestrous cycle of the rat.	phenethylamine	45-48	monoamine oxidase B	Rattus norvegicus	88-93
435561-5	1979	In analogous experiments with deprenyl (the specific inhibitor of MAO type B) 4-ethylpyridine (5.10(-3) M) decreased the inhibitory effect of deprenyl not only on the deamination of serotonin (substrate of MAO A), but also on the oxidation of beta-phenylethylamine (the main substrate of MAO type B).	phenethylamine	243-264	monoamine oxidase A	Rattus norvegicus	66-69
32944-1	1979	1 Metabolism of 5-hydroxytryptamine (5-HT) and beta-phenylethylamine (PHE) by monoamine oxidase (MAO) was investigated in rat isolated lungs and in mitochondrial preparations from rat lung.	phenethylamine	47-68	monoamine oxidase A	Rattus norvegicus	97-100
32944-1	1979	1 Metabolism of 5-hydroxytryptamine (5-HT) and beta-phenylethylamine (PHE) by monoamine oxidase (MAO) was investigated in rat isolated lungs and in mitochondrial preparations from rat lung.	phenethylamine	70-73	monoamine oxidase A	Rattus norvegicus	78-95
32944-1	1979	1 Metabolism of 5-hydroxytryptamine (5-HT) and beta-phenylethylamine (PHE) by monoamine oxidase (MAO) was investigated in rat isolated lungs and in mitochondrial preparations from rat lung.	phenethylamine	70-73	monoamine oxidase A	Rattus norvegicus	97-100
595495-3	1977	Interaction of N-(8-quinolylmethyl)-N-methyl-2-propinyl amine with MAO of the A type (serotonin as a substrate) and of the B type (beta-phenylethylamine as a substrate) was studied by the kinetic method, which enabled to determine and quantitatively estimate the steps of enzyme-inhibitor complexes formation.	phenethylamine	131-152	monoamine oxidase A	Rattus norvegicus	67-70
490150-7	1979	Pineal monoamine oxidase (MAO) activity type B (assaying by using beta-phenylethylamine as substrate) was decreased by FSH or LH injection.	phenethylamine	66-87	monoamine oxidase A	Rattus norvegicus	7-24
490150-7	1979	Pineal monoamine oxidase (MAO) activity type B (assaying by using beta-phenylethylamine as substrate) was decreased by FSH or LH injection.	phenethylamine	66-87	monoamine oxidase A	Rattus norvegicus	26-29
711033-2	1978	The rates of serotonin, beta-phenylethylamine and benzylamine oxidations by placental MAO were approximately 191, 12 and 48% to those of rat liver MAO, respectively.	phenethylamine	24-45	monoamine oxidase A	Rattus norvegicus	86-89
745019-1	1978	Deprenyl is an inhibitor of monoamine oxidase type B, the enzyme responsible for 2-phenylethylamine oxidation, and is used in conjunction with L-Dopa therapy in Parkinson"s disease.	phenethylamine	81-99	monoamine oxidase B	Homo sapiens	28-52
595495-5	1977	The data on K1 values, estimated in experiments with serotonin and beta-phenylethylamine as substrates, show that the affinity of N-(8-quinolyl methyl)-N-methyl-2-propinyl amine towards MAO of the A type was 10-fold higher than the affinity towards MAO of the B type.	phenethylamine	67-88	monoamine oxidase A	Rattus norvegicus	186-189
595495-5	1977	The data on K1 values, estimated in experiments with serotonin and beta-phenylethylamine as substrates, show that the affinity of N-(8-quinolyl methyl)-N-methyl-2-propinyl amine towards MAO of the A type was 10-fold higher than the affinity towards MAO of the B type.	phenethylamine	67-88	monoamine oxidase A	Rattus norvegicus	249-252
887501-4	1977	Deprenyl is a selective inhibitor of the "B form" of MAO, which preferentially oxidizes beta-phenylethylamine as substrate.	phenethylamine	88-109	monoamine oxidase A	Rattus norvegicus	53-56
833580-0	1977	Desynchronization of electrical activity in rats induced by deprenyl--an inhibitor of monoamine oxidase B--and relationship with selective increase of dopamine and beta-phenylethylamine.	phenethylamine	164-185	monoamine oxidase B	Rattus norvegicus	86-105
1248576-1	1976	The distribution of type A and B monamine oxidase (MAO) activities in the central nervous system (CNS) of rat and chick was investigated using 5-hydroxytryptamine and beta-phenylethylamine as specific substrates.	phenethylamine	167-188	monoamine oxidase A	Rattus norvegicus	51-54
956156-1	1976	A simple fluorometric assay for monoamine oxidase (MAO) [EC 1.4.3.4] activity towards beta-phenylethylamine (PEA) was devised.	phenethylamine	86-107	monoamine oxidase A	Rattus norvegicus	32-49
956156-1	1976	A simple fluorometric assay for monoamine oxidase (MAO) [EC 1.4.3.4] activity towards beta-phenylethylamine (PEA) was devised.	phenethylamine	86-107	monoamine oxidase A	Rattus norvegicus	51-54
956156-1	1976	A simple fluorometric assay for monoamine oxidase (MAO) [EC 1.4.3.4] activity towards beta-phenylethylamine (PEA) was devised.	phenethylamine	109-112	monoamine oxidase A	Rattus norvegicus	32-49
956156-1	1976	A simple fluorometric assay for monoamine oxidase (MAO) [EC 1.4.3.4] activity towards beta-phenylethylamine (PEA) was devised.	phenethylamine	109-112	monoamine oxidase A	Rattus norvegicus	51-54
1241962-6	1975	l-Deprenyl but not clorgyline (2 or 8 mg/kg s.c.) potentiated the stereotyped sniffing behaviour induced by beta-phenylethylamine, a specific substrate for type B monoamine oxidase.	phenethylamine	108-129	monoamine oxidase A	Rattus norvegicus	163-180
934359-1	1976	The effect of graded doses of clorgyline, a preferential inhibitor of MAO A, and of deprenil, a preferential inhibitor of MAO B, on the activities of serotonin-deaminating MAO (MAO A) of dopamine-deaminating MAO, and of phenethylamine-deaminating MAO, (MAO  B), in rat corpus striatum were compared with the effects of the drugs on striatal levels of homovanillic acid(HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC).	phenethylamine	220-234	monoamine oxidase A	Rattus norvegicus	177-182
1133822-1	1975	Norepinephrine N-methyltransferase (NMT) from rabbit adrenal glands was inhibited by benzylamine and phenethylamine analogs in which the nitrogen was replaced by an amidino or guanidino group.	phenethylamine	101-115	N-myristoyltransferase 1	Homo sapiens	36-39
33785135-4	2021	Activation of 5-HT2A receptors by the phenethylamine hallucinogen also appears to increase asynchronous release of glutamate upon the layer V pyramidal dendritic field, an effect that is suppressed by 5-HT itself through non-5-HT2A receptors.	phenethylamine	38-52	5-hydroxytryptamine receptor 2A	Homo sapiens	14-20
33772383-0	2021	Anti-rheumatic activity of pseudoephedrine (a substituted phenethylamine) in complete Freund"s adjuvant-induced arthritic rats by down regulating IL-1beta, IL-6 and TNF-alpha as well as upregulating IL-4 and IL-10.	phenethylamine	58-72	interleukin 1 alpha	Rattus norvegicus	146-154
33785135-4	2021	Activation of 5-HT2A receptors by the phenethylamine hallucinogen also appears to increase asynchronous release of glutamate upon the layer V pyramidal dendritic field, an effect that is suppressed by 5-HT itself through non-5-HT2A receptors.	phenethylamine	38-52	5-hydroxytryptamine receptor 2A	Homo sapiens	16-20
33265983-0	2020	2-Phenylethylamine (PEA) Ameliorates Corticosterone-Induced Depression-Like Phenotype via the BDNF/TrkB/CREB Signaling Pathway.	phenethylamine	0-18	brain derived neurotrophic factor	Mus musculus	94-98
33265983-11	2020	Our findings reveal that PEA exerts antidepressant effects by modulating the BDNF/TrkB/CREB signaling pathway in a mouse model of CORT-induced depression.	phenethylamine	25-28	brain derived neurotrophic factor	Mus musculus	77-81
33265983-0	2020	2-Phenylethylamine (PEA) Ameliorates Corticosterone-Induced Depression-Like Phenotype via the BDNF/TrkB/CREB Signaling Pathway.	phenethylamine	0-18	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	99-103
33265983-11	2020	Our findings reveal that PEA exerts antidepressant effects by modulating the BDNF/TrkB/CREB signaling pathway in a mouse model of CORT-induced depression.	phenethylamine	25-28	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	82-86
33265983-0	2020	2-Phenylethylamine (PEA) Ameliorates Corticosterone-Induced Depression-Like Phenotype via the BDNF/TrkB/CREB Signaling Pathway.	phenethylamine	0-18	cAMP responsive element binding protein 1	Mus musculus	104-108
33265983-11	2020	Our findings reveal that PEA exerts antidepressant effects by modulating the BDNF/TrkB/CREB signaling pathway in a mouse model of CORT-induced depression.	phenethylamine	25-28	cAMP responsive element binding protein 1	Mus musculus	87-91
33265983-0	2020	2-Phenylethylamine (PEA) Ameliorates Corticosterone-Induced Depression-Like Phenotype via the BDNF/TrkB/CREB Signaling Pathway.	phenethylamine	20-23	brain derived neurotrophic factor	Mus musculus	94-98
33265983-0	2020	2-Phenylethylamine (PEA) Ameliorates Corticosterone-Induced Depression-Like Phenotype via the BDNF/TrkB/CREB Signaling Pathway.	phenethylamine	20-23	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	99-103
33265983-0	2020	2-Phenylethylamine (PEA) Ameliorates Corticosterone-Induced Depression-Like Phenotype via the BDNF/TrkB/CREB Signaling Pathway.	phenethylamine	20-23	cAMP responsive element binding protein 1	Mus musculus	104-108
33081086-1	2020	Monoamine oxidase B (MAOB) is expressed in the mitochondrial membrane and has a key role in degrading various neurologically active amines such as benzylamine, phenethylamine and dopamine with the help of Flavin adenine dinucleotide (FAD) cofactor.	phenethylamine	160-174	monoamine oxidase B	Homo sapiens	0-19
33103897-5	2020	Using phenethylamine (PA) as a specific substrate of MAOB, the enzyme product phenylacetaldehyde (PAA) will produce significant Raman signals via the amine-aldehyde click reaction with CA, while other molecules, such as MAOB and PA, have no signal output because they cannot form close interaction with nanoparticles due to the existence of a CA layer.	phenethylamine	6-20	monoamine oxidase B	Homo sapiens	53-57
33103897-5	2020	Using phenethylamine (PA) as a specific substrate of MAOB, the enzyme product phenylacetaldehyde (PAA) will produce significant Raman signals via the amine-aldehyde click reaction with CA, while other molecules, such as MAOB and PA, have no signal output because they cannot form close interaction with nanoparticles due to the existence of a CA layer.	phenethylamine	6-20	monoamine oxidase B	Homo sapiens	220-224
33103897-5	2020	Using phenethylamine (PA) as a specific substrate of MAOB, the enzyme product phenylacetaldehyde (PAA) will produce significant Raman signals via the amine-aldehyde click reaction with CA, while other molecules, such as MAOB and PA, have no signal output because they cannot form close interaction with nanoparticles due to the existence of a CA layer.	phenethylamine	22-24	monoamine oxidase B	Homo sapiens	53-57
33103897-5	2020	Using phenethylamine (PA) as a specific substrate of MAOB, the enzyme product phenylacetaldehyde (PAA) will produce significant Raman signals via the amine-aldehyde click reaction with CA, while other molecules, such as MAOB and PA, have no signal output because they cannot form close interaction with nanoparticles due to the existence of a CA layer.	phenethylamine	22-24	monoamine oxidase B	Homo sapiens	220-224
33103897-5	2020	Using phenethylamine (PA) as a specific substrate of MAOB, the enzyme product phenylacetaldehyde (PAA) will produce significant Raman signals via the amine-aldehyde click reaction with CA, while other molecules, such as MAOB and PA, have no signal output because they cannot form close interaction with nanoparticles due to the existence of a CA layer.	phenethylamine	98-100	monoamine oxidase B	Homo sapiens	53-57
33103897-5	2020	Using phenethylamine (PA) as a specific substrate of MAOB, the enzyme product phenylacetaldehyde (PAA) will produce significant Raman signals via the amine-aldehyde click reaction with CA, while other molecules, such as MAOB and PA, have no signal output because they cannot form close interaction with nanoparticles due to the existence of a CA layer.	phenethylamine	98-100	monoamine oxidase B	Homo sapiens	220-224
33081086-1	2020	Monoamine oxidase B (MAOB) is expressed in the mitochondrial membrane and has a key role in degrading various neurologically active amines such as benzylamine, phenethylamine and dopamine with the help of Flavin adenine dinucleotide (FAD) cofactor.	phenethylamine	160-174	monoamine oxidase B	Homo sapiens	21-25
31678493-6	2020	We therefore investigated the effect of TAAR ligands on cAMP signalling and insulin secretion, and found that only the branch of the TAAR family tree that is activated by isopentylamine, 2-phenylethylamine, p-tyramine, and agmatine significantly increased intracellular cAMP and resulted in increased insulin secretion from INS-1 cells and primary mouse islets under normal conditions.	phenethylamine	187-205	insulin	Homo sapiens	76-83
32064387-3	2020	We synthesized five phenethylamine analogs in which the benzene ring is replaced by a bulky dibenzo[b,d]furan moiety and found a couple with >70-fold 5-HT2C selectivity.	phenethylamine	20-34	5-hydroxytryptamine receptor 2C	Homo sapiens	150-156
31678493-6	2020	We therefore investigated the effect of TAAR ligands on cAMP signalling and insulin secretion, and found that only the branch of the TAAR family tree that is activated by isopentylamine, 2-phenylethylamine, p-tyramine, and agmatine significantly increased intracellular cAMP and resulted in increased insulin secretion from INS-1 cells and primary mouse islets under normal conditions.	phenethylamine	187-205	insulin	Homo sapiens	301-308
30448990-0	2019	Chronic treatment with a metabotropic mGlu2/3 receptor agonist diminishes behavioral response to a phenethylamine hallucinogen.	phenethylamine	99-113	glutamate receptor, metabotropic 3	Mus musculus	38-45
31849671-7	2019	Results: Both the phenethylamine and amphetamine derivatives (K i = 8-1700 nM and 61-4400 nM, respectively) bound with moderate to high affinities to the 5-HT2A receptor with preference over the 5-HT1A and 5-HT2C receptors (5-HT2A/5-HT1A = 1.4-333 and 5-HT2A/5-HT2C = 2.1-14, respectively).	phenethylamine	18-32	5-hydroxytryptamine receptor 2A	Homo sapiens	154-169
31849671-7	2019	Results: Both the phenethylamine and amphetamine derivatives (K i = 8-1700 nM and 61-4400 nM, respectively) bound with moderate to high affinities to the 5-HT2A receptor with preference over the 5-HT1A and 5-HT2C receptors (5-HT2A/5-HT1A = 1.4-333 and 5-HT2A/5-HT2C = 2.1-14, respectively).	phenethylamine	18-32	5-hydroxytryptamine receptor 1A	Homo sapiens	195-201
31849671-7	2019	Results: Both the phenethylamine and amphetamine derivatives (K i = 8-1700 nM and 61-4400 nM, respectively) bound with moderate to high affinities to the 5-HT2A receptor with preference over the 5-HT1A and 5-HT2C receptors (5-HT2A/5-HT1A = 1.4-333 and 5-HT2A/5-HT2C = 2.1-14, respectively).	phenethylamine	18-32	5-hydroxytryptamine receptor 2A	Homo sapiens	154-160
31849671-12	2019	Conclusion: As seen with earlier series investigated, the 4-alkyloxy-substituted 2,5-dimethoxyamphetamines and phenethylamines share some trends with the many other phenethylamine pharmacophore containing compounds, such as when increasing the size of the 4-substituent and increasing the lipophilicity, the affinities at the 5-HT2A/C subtype also increase, and only weak 5-HT2A/C subtype selectivities were achieved.	phenethylamine	111-125	5-hydroxytryptamine receptor 2A	Homo sapiens	326-332
31849671-12	2019	Conclusion: As seen with earlier series investigated, the 4-alkyloxy-substituted 2,5-dimethoxyamphetamines and phenethylamines share some trends with the many other phenethylamine pharmacophore containing compounds, such as when increasing the size of the 4-substituent and increasing the lipophilicity, the affinities at the 5-HT2A/C subtype also increase, and only weak 5-HT2A/C subtype selectivities were achieved.	phenethylamine	111-125	5-hydroxytryptamine receptor 2A	Homo sapiens	372-378
31532677-0	2019	Palladium-Catalyzed C(sp2)-H Olefination of Free Primary and Secondary 2-Phenylethylamines: Access to Tetrahydroisoquinolines.	phenethylamine	71-90	Sp2 transcription factor	Homo sapiens	20-25
31349085-3	2019	Inhibition of nitric oxide synthase (NOS) with Nomega-nitro-L-arginine (L-NAME) potentiates vasoconstriction by phenylephrine and the trace amine, beta-phenylethylamine (PEA), indicating underlying opposing vasodilatation.	phenethylamine	147-168	nitric oxide synthase, inducible	Cavia porcellus	14-35
31349085-3	2019	Inhibition of nitric oxide synthase (NOS) with Nomega-nitro-L-arginine (L-NAME) potentiates vasoconstriction by phenylephrine and the trace amine, beta-phenylethylamine (PEA), indicating underlying opposing vasodilatation.	phenethylamine	170-173	nitric oxide synthase, inducible	Cavia porcellus	14-35
31303592-2	2019	In this research paper, ligand based virtual screening has been performed in order to predict the inhibitors for monoamine oxidase (MAO-B), an enzyme specifically involved in the metabolism of non-hydroxylated amines such as benzylamine and beta-phenylethylamine (PEA), thus, could be the target to treat various neurodegenerative disorders like Parkinson"s disease.	phenethylamine	241-262	monoamine oxidase B	Homo sapiens	132-137
31303592-2	2019	In this research paper, ligand based virtual screening has been performed in order to predict the inhibitors for monoamine oxidase (MAO-B), an enzyme specifically involved in the metabolism of non-hydroxylated amines such as benzylamine and beta-phenylethylamine (PEA), thus, could be the target to treat various neurodegenerative disorders like Parkinson"s disease.	phenethylamine	264-267	monoamine oxidase B	Homo sapiens	132-137
31556440-2	2019	This work measures a reduction in selectivity for the MAOB isoform of 3 to 9.5 kJ mol-1 upon the addition of hydroxy functional groups to a phenethylamine scaffold.	phenethylamine	140-154	monoamine oxidase B	Homo sapiens	54-58
31556440-3	2019	Replacement of hydroxy functional groups on the phenethylamine scaffold by hydrophobic substituents measures an increase in selectivity for MAOB of -1.1 to -6.9 kJ mol-1.	phenethylamine	48-62	monoamine oxidase B	Homo sapiens	140-144
31265842-6	2019	beta-phenethylamine was the most potent, with IC50 values of 0.05 and 1.8 muM at the NET and DAT, respectively.	phenethylamine	0-19	latexin	Homo sapiens	74-77
31265842-6	2019	beta-phenethylamine was the most potent, with IC50 values of 0.05 and 1.8 muM at the NET and DAT, respectively.	phenethylamine	0-19	solute carrier family 6 member 3	Homo sapiens	93-96
31572197-11	2019	In heterozygosity, the three TAAR1 variants substantially dampened Gs signaling in response to PEA, and, more robustly, to T1AM.	phenethylamine	95-98	trace amine associated receptor 1	Homo sapiens	29-34
31120257-0	2019	Ligand Promoted, Palladium-Catalyzed C(sp2)-H Arylation of Free Primary 2-Phenylethylamines.	phenethylamine	72-91	Sp2 transcription factor	Homo sapiens	37-42
31120257-1	2019	A mono- N-protected amino acid (MPAA) ligand promoted, Pd(II)-catalyzed C(sp2)-H arylation of free primary 2-phenylethylamines using the native NH2 as the directing group has been achieved.	phenethylamine	107-126	Sp2 transcription factor	Homo sapiens	72-77
30448990-3	2019	In this study, we investigated whether chronic treatment with the mGlu2/3 agonist LY379268 would alter the behavioral response to a phenethylamine hallucinogen, 25CN-NBOH, which acts as a selective 5-HT2A agonist.	phenethylamine	132-146	glutamate receptor, metabotropic 3	Mus musculus	66-73
30448990-3	2019	In this study, we investigated whether chronic treatment with the mGlu2/3 agonist LY379268 would alter the behavioral response to a phenethylamine hallucinogen, 25CN-NBOH, which acts as a selective 5-HT2A agonist.	phenethylamine	132-146	5-hydroxytryptamine (serotonin) receptor 2A	Mus musculus	198-204
29375386-3	2017	In vitro, TAAR1 is activated with nanomolar to micromolar affinity by some endogenous amines, particularly p-tyramine, beta-phenylethylamine, and 3-iodothyronamine (T1AM), the latter representing a novel branch of thyroid hormone signaling.	phenethylamine	119-140	trace amine associated receptor 1	Homo sapiens	10-15
30229988-13	2019	The contractile effect appeared to involve the recruitment of 5-HT receptors, and the relaxant effect of beta-PEA on KCl-elicited contractions likely involved TAAR1 .	phenethylamine	105-113	trace-amine-associated receptor 1	Rattus norvegicus	159-164
29202379-5	2018	Platelet MAO-B activity was measured with 2-phenylethylamine (b-PEA) as substrate.	phenethylamine	42-60	monoamine oxidase B	Homo sapiens	9-14
29375386-6	2017	In particular, beta-phenylethylamine and p-tyramine have been reported to modify the release and/or the response to dopamine, norepinephrine, acetylcholine and GABA, while evidence of cross-talk between TAAR1 and other aminergic receptors has been provided.	phenethylamine	15-36	trace amine associated receptor 1	Homo sapiens	203-208
28084165-0	2017	Tyramine and beta-phenylethylamine, from fermented food products, as agonists for the human trace amine-associated receptor 1 (hTAAR1) in the stomach.	phenethylamine	13-34	trace amine associated receptor 1	Homo sapiens	92-125
28084165-0	2017	Tyramine and beta-phenylethylamine, from fermented food products, as agonists for the human trace amine-associated receptor 1 (hTAAR1) in the stomach.	phenethylamine	13-34	trace amine associated receptor 1	Homo sapiens	127-133
28084165-6	2017	The CRE-SEAP reporter assay revealed that only hTAAR1 functioned as a Gs-coupled receptor in response to tyramine and beta-phenylethylamine stimulation.	phenethylamine	118-139	trace amine associated receptor 1	Homo sapiens	47-53
28084165-7	2017	The beta-phenylethylamine-mediated hTAAR1 activity could be potentiated using 3-isobutyl-1-methylxanthine.	phenethylamine	4-25	trace amine associated receptor 1	Homo sapiens	35-41
28084165-8	2017	These data suggest that tyramine and beta-phenylethylamine in fermented foods act at hTAAR1 as agonists in the pylorus of stomach.	phenethylamine	37-58	trace amine associated receptor 1	Homo sapiens	85-91
27092049-3	2016	At the turn of the century, the discovery of the trace amine-associated receptor 1 (TAAR1), a phylogenetically conserved G protein-coupled receptor that is responsive to both TAs, such as beta-phenylethylamine, octopamine, and tyramine, and structurally-related amphetamines, unveiled mechanisms of action for TAs other than interference with aminergic pathways, laying the foundations for deciphering the functional significance of TAs and its mammalian CNS receptor, TAAR1.	phenethylamine	188-209	trace amine associated receptor 1	Homo sapiens	49-82
28097528-4	2017	Addition of an N-benzyl group to phenethylamine hallucinogens produces a marked increase in 5-HT2A-binding affinity and hallucinogenic potency.	phenethylamine	33-47	5-hydroxytryptamine receptor 2A	Homo sapiens	92-98
27486905-6	2016	Furthermore, Mg2(olz) was used to encapsulate phenethylamine (PEA), a model drug for a broad class of bioactive compounds.	phenethylamine	46-60	mucin 7, secreted	Homo sapiens	13-16
27486905-6	2016	Furthermore, Mg2(olz) was used to encapsulate phenethylamine (PEA), a model drug for a broad class of bioactive compounds.	phenethylamine	62-65	mucin 7, secreted	Homo sapiens	13-16
27608273-2	2016	Conjugate addition of phenethylamine to an achiral aroyl acrylamide under homogeneous conditions gave the alpha-amino amides in quantitative yields, which crystallized as a conglomerate of a P21 crystal system.	phenethylamine	22-36	H3 histone pseudogene 16	Homo sapiens	191-194
27092049-3	2016	At the turn of the century, the discovery of the trace amine-associated receptor 1 (TAAR1), a phylogenetically conserved G protein-coupled receptor that is responsive to both TAs, such as beta-phenylethylamine, octopamine, and tyramine, and structurally-related amphetamines, unveiled mechanisms of action for TAs other than interference with aminergic pathways, laying the foundations for deciphering the functional significance of TAs and its mammalian CNS receptor, TAAR1.	phenethylamine	188-209	trace amine associated receptor 1	Homo sapiens	84-89
27092049-3	2016	At the turn of the century, the discovery of the trace amine-associated receptor 1 (TAAR1), a phylogenetically conserved G protein-coupled receptor that is responsive to both TAs, such as beta-phenylethylamine, octopamine, and tyramine, and structurally-related amphetamines, unveiled mechanisms of action for TAs other than interference with aminergic pathways, laying the foundations for deciphering the functional significance of TAs and its mammalian CNS receptor, TAAR1.	phenethylamine	188-209	trace amine associated receptor 1	Homo sapiens	469-474
25583099-1	2015	N-Benzyl substitution of phenethylamine 5-HT2A receptor agonists has dramatic effects on binding affinity, receptor selectivity and agonist activity.	phenethylamine	25-39	5-hydroxytryptamine receptor 2A	Homo sapiens	40-55
26791601-8	2016	Most amphetamines, phenethylamine, and aminoindanes exhibited potentially physiologically relevant rat and mouse TAAR1 activation (EC50 < 5 microM) and showed full or partial (Emax < 80%) agonist properties.	phenethylamine	19-33	trace amine-associated receptor 1	Mus musculus	113-118
27031617-1	2016	Methamphetamine (MA) and neurotransmitter precursors and metabolites such as tyramine, octopamine, and beta-phenethylamine stimulate the G protein-coupled trace amine-associated receptor 1 (TAAR1).	phenethylamine	103-122	trace amine-associated receptor 1	Mus musculus	155-188
27031617-1	2016	Methamphetamine (MA) and neurotransmitter precursors and metabolites such as tyramine, octopamine, and beta-phenethylamine stimulate the G protein-coupled trace amine-associated receptor 1 (TAAR1).	phenethylamine	103-122	trace amine-associated receptor 1	Mus musculus	190-195
26601069-1	2015	OBJECTIVES: The trace amine-associated receptor 1 (Taar1) is a Gs protein-coupled receptor activated by trace amines, such as beta-phenylethylamine (beta-PEA) and 3-iodothyronamine (T1AM).	phenethylamine	126-147	trace-amine-associated receptor 1	Rattus norvegicus	16-49
26601069-1	2015	OBJECTIVES: The trace amine-associated receptor 1 (Taar1) is a Gs protein-coupled receptor activated by trace amines, such as beta-phenylethylamine (beta-PEA) and 3-iodothyronamine (T1AM).	phenethylamine	126-147	trace-amine-associated receptor 1	Rattus norvegicus	51-56
26601069-1	2015	OBJECTIVES: The trace amine-associated receptor 1 (Taar1) is a Gs protein-coupled receptor activated by trace amines, such as beta-phenylethylamine (beta-PEA) and 3-iodothyronamine (T1AM).	phenethylamine	149-157	trace-amine-associated receptor 1	Rattus norvegicus	16-49
26601069-1	2015	OBJECTIVES: The trace amine-associated receptor 1 (Taar1) is a Gs protein-coupled receptor activated by trace amines, such as beta-phenylethylamine (beta-PEA) and 3-iodothyronamine (T1AM).	phenethylamine	149-157	trace-amine-associated receptor 1	Rattus norvegicus	51-56
26601069-11	2015	In contrast, beta-PEA and p-Tyr potencies were rather conserved throughout all tested Taar1 orthologs.	phenethylamine	13-21	trace-amine-associated receptor 1	Rattus norvegicus	86-91
25548026-2	2015	METHODS: This review focuses on DAT ligands, such as benztropine, GBR 12909, modafinil, and DAT substrates derived from phenethylamine or cathinone that have atypical DAT-inhibitor effects, either in vitro or in vivo.	phenethylamine	120-134	Dopamine transporter	Drosophila melanogaster	32-35
25548026-2	2015	METHODS: This review focuses on DAT ligands, such as benztropine, GBR 12909, modafinil, and DAT substrates derived from phenethylamine or cathinone that have atypical DAT-inhibitor effects, either in vitro or in vivo.	phenethylamine	120-134	Dopamine transporter	Drosophila melanogaster	92-95
25548026-2	2015	METHODS: This review focuses on DAT ligands, such as benztropine, GBR 12909, modafinil, and DAT substrates derived from phenethylamine or cathinone that have atypical DAT-inhibitor effects, either in vitro or in vivo.	phenethylamine	120-134	Dopamine transporter	Drosophila melanogaster	92-95
24950453-6	2014	METH and beta-phenylethylamine (beta-PEA), known TAAR1 agonists, increased intracellular cAMP levels in astrocytes.	phenethylamine	32-40	trace amine associated receptor 1	Homo sapiens	49-54
24894156-1	2014	Trace Amine-Associated Receptor 1 (TAAR1) is a G protein-coupled receptor that is expressed in brain and periphery and responds to a class of compounds called trace amines, such as beta-phenylethylamine (beta-PEA), tyramine, tryptamine, octopamine.	phenethylamine	181-202	trace amine associated receptor 1	Homo sapiens	0-33
24894156-1	2014	Trace Amine-Associated Receptor 1 (TAAR1) is a G protein-coupled receptor that is expressed in brain and periphery and responds to a class of compounds called trace amines, such as beta-phenylethylamine (beta-PEA), tyramine, tryptamine, octopamine.	phenethylamine	181-202	trace amine associated receptor 1	Homo sapiens	35-40
24894156-1	2014	Trace Amine-Associated Receptor 1 (TAAR1) is a G protein-coupled receptor that is expressed in brain and periphery and responds to a class of compounds called trace amines, such as beta-phenylethylamine (beta-PEA), tyramine, tryptamine, octopamine.	phenethylamine	204-212	trace amine associated receptor 1	Homo sapiens	0-33
24894156-1	2014	Trace Amine-Associated Receptor 1 (TAAR1) is a G protein-coupled receptor that is expressed in brain and periphery and responds to a class of compounds called trace amines, such as beta-phenylethylamine (beta-PEA), tyramine, tryptamine, octopamine.	phenethylamine	204-212	trace amine associated receptor 1	Homo sapiens	35-40
25271256-6	2014	These studies suggest that the use of phenethylamine-derived hallucinogens as therapeutic agents may be limited not only by their abuse potential, but also by the rapid development of tolerance that would likely be maintained even if a patient were switched to a different 5-HT2A agonist medication from a distinct structural class.	phenethylamine	38-52	5-hydroxytryptamine receptor 2A	Homo sapiens	273-279
25271256-7	2014	However, these experiments also imply that tryptamine-derived hallucinogens might have a reduced potential for tolerance development, compared with phenethylamine-derived 5-HT2A agonists, and might therefore be more suitable for chronic administration in a therapeutic context.	phenethylamine	148-162	5-hydroxytryptamine (serotonin) receptor 2A	Mus musculus	171-177
25253656-0	2014	Profiling substrate specificity of two series of phenethylamine analogs at monoamine oxidase A and B.	phenethylamine	49-63	monoamine oxidase A	Homo sapiens	75-100
25253656-3	2014	In this study we present a systematic study of the MAO-A and MAO-B substrate specificity profile by probing two series of phenethylamine analogs.	phenethylamine	122-136	monoamine oxidase A	Homo sapiens	51-56
25253656-3	2014	In this study we present a systematic study of the MAO-A and MAO-B substrate specificity profile by probing two series of phenethylamine analogs.	phenethylamine	122-136	monoamine oxidase B	Homo sapiens	61-66
25426030-1	2014	The trace amines (TAs), tryptamine, tyramine, and beta-phenylethylamine, are synthesized from precursor amino acids via aromatic-L-amino acid decarboxylase (AADC).	phenethylamine	50-71	dopa decarboxylase	Homo sapiens	120-155
25426030-1	2014	The trace amines (TAs), tryptamine, tyramine, and beta-phenylethylamine, are synthesized from precursor amino acids via aromatic-L-amino acid decarboxylase (AADC).	phenethylamine	50-71	dopa decarboxylase	Homo sapiens	157-161
24950453-6	2014	METH and beta-phenylethylamine (beta-PEA), known TAAR1 agonists, increased intracellular cAMP levels in astrocytes.	phenethylamine	9-30	trace amine associated receptor 1	Homo sapiens	49-54
23638910-0	2013	beta-phenethylamine--a phenylalanine derivative in brain--contributes to oxidative stress by inhibiting mitochondrial complexes and DT-diaphorase: an in silico study.	phenethylamine	0-19	NAD(P)H quinone dehydrogenase 1	Homo sapiens	132-145
24397362-1	2014	N-Benzyl substitution of 5-HT2A receptor agonists of the phenethylamine structural class of psychedelics (such as 4-bromo-2,5-dimethoxyphenethylamine, often referred to as 2C-B) confer a significant increase in binding affinity as well as functional activity of the receptor.	phenethylamine	57-71	5-hydroxytryptamine receptor 2A	Homo sapiens	25-40
24244317-3	2013	Conformationally constrained phenethylamine analogs have demonstrated that for optimal activity the free lone pair electrons of the 2-oxygen must be oriented syn and the 5-oxygen lone pairs anti relative to the ethylamine moiety.	phenethylamine	29-43	synemin	Homo sapiens	158-161
23665489-3	2013	beta-PEA, d-amphetamine, MDMA, cathinone and methylphenidate caused concentration-dependent contractions of rat isolated aortic rings which were unaffected by prazosin (1 muM), ICI-118,551 (1 muM), cocaine (10 muM) and pargyline (10 muM), to inhibit alpha1- and beta2-adrenoceptors, neuronal transport and monoamine oxidase (MAO), respectively.	phenethylamine	0-8	monoamine oxidase A	Rattus norvegicus	306-323
23665489-3	2013	beta-PEA, d-amphetamine, MDMA, cathinone and methylphenidate caused concentration-dependent contractions of rat isolated aortic rings which were unaffected by prazosin (1 muM), ICI-118,551 (1 muM), cocaine (10 muM) and pargyline (10 muM), to inhibit alpha1- and beta2-adrenoceptors, neuronal transport and monoamine oxidase (MAO), respectively.	phenethylamine	0-8	monoamine oxidase A	Rattus norvegicus	325-328
23858446-2	2013	The combined deficiency of MAO A and B results in significantly elevated levels of serotonin (5-hydroxytryptamine), norepinephrine, dopamine, and beta-phenylethylamine; in humans and mice, these neurochemical changes are accompanied by neurodevelopmental perturbations as well as autistic-like responses.	phenethylamine	146-167	monoamine oxidase A	Homo sapiens	27-38
21944855-0	2011	Synthesis and evaluation of pyridazinone-phenethylamine derivatives as selective and orally bioavailable histamine H3 receptor antagonists with robust wake-promoting activity.	phenethylamine	41-55	histamine receptor H3	Rattus norvegicus	105-126
23371965-6	2013	GSH-adducts of phenethyl isocyanate (PIC) and phenethylamine were detected during the metabolism by CYP2E1, indicating formation of PIC as a reactive intermediate following P450-catalyzed desulfurization of PEITC.	phenethylamine	46-60	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	100-106
23336049-1	2013	Based on the structure of the superpotent 5-HT(2A) agonist 2-(4-bromo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine, which consists of a ring-substituted phenethylamine skeleton modified with an N-benzyl group, we designed and synthesized a small library of constrained analogues to identify the optimal arrangement of the pharmacophoric elements of the ligand.	phenethylamine	167-181	5-hydroxytryptamine receptor 2A	Homo sapiens	42-49
22883051-1	2013	Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor that belongs to the family of TAAR receptors and responds to a class of compounds called trace amines, such as beta-phenylethylamine (beta-PEA) and 3-iodothyronamine (T(1)AM).	phenethylamine	185-206	trace amine associated receptor 1	Homo sapiens	0-33
22883051-1	2013	Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor that belongs to the family of TAAR receptors and responds to a class of compounds called trace amines, such as beta-phenylethylamine (beta-PEA) and 3-iodothyronamine (T(1)AM).	phenethylamine	185-206	trace amine associated receptor 1	Homo sapiens	35-40
22883051-1	2013	Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor that belongs to the family of TAAR receptors and responds to a class of compounds called trace amines, such as beta-phenylethylamine (beta-PEA) and 3-iodothyronamine (T(1)AM).	phenethylamine	208-216	trace amine associated receptor 1	Homo sapiens	0-33
22883051-1	2013	Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor that belongs to the family of TAAR receptors and responds to a class of compounds called trace amines, such as beta-phenylethylamine (beta-PEA) and 3-iodothyronamine (T(1)AM).	phenethylamine	208-216	trace amine associated receptor 1	Homo sapiens	35-40
20641293-2	2004	MAO-A preferentially oxidizes serotonin and noradrenaline, whereas MAO-B preferentially oxidizes phenethylamine.	phenethylamine	97-111	monoamine oxidase B	Homo sapiens	67-72
21944855-1	2011	A series of pyridazinone-phenethylamine derivatives with moderate to low nanomolar affinity for rat and human H(3)R are described.	phenethylamine	25-39	histamine receptor H3	Homo sapiens	110-115
21210285-4	2011	Further, Trace Amine-Associated Receptor 1 (TAAR1), which is selectively activated by PE and TA, is intracellular.	phenethylamine	86-88	trace amine associated receptor 1	Homo sapiens	9-42
21670104-3	2011	TAAR1 is a Galpha(s) protein-coupled receptor that is activated by biogenic amines, "trace amines," such as beta-phenylethylamine (beta-PEA) and tyramine that are normally found at low concentrations in the mammalian brain.	phenethylamine	108-129	trace amine associated receptor 1	Homo sapiens	0-5
21670104-3	2011	TAAR1 is a Galpha(s) protein-coupled receptor that is activated by biogenic amines, "trace amines," such as beta-phenylethylamine (beta-PEA) and tyramine that are normally found at low concentrations in the mammalian brain.	phenethylamine	131-139	trace amine associated receptor 1	Homo sapiens	0-5
21210285-4	2011	Further, Trace Amine-Associated Receptor 1 (TAAR1), which is selectively activated by PE and TA, is intracellular.	phenethylamine	86-88	trace amine associated receptor 1	Homo sapiens	44-49
21525407-1	2011	The trace amine-associated receptor 1 (TAAR1), activated by endogenous metabolites of amino acids like the trace amines p-tyramine and beta-phenylethylamine, has proven to be an important modulator of the dopaminergic system and is considered a promising target for the treatment of neuropsychiatric disorders.	phenethylamine	135-156	trace amine-associated receptor 1	Mus musculus	4-37
21525407-1	2011	The trace amine-associated receptor 1 (TAAR1), activated by endogenous metabolites of amino acids like the trace amines p-tyramine and beta-phenylethylamine, has proven to be an important modulator of the dopaminergic system and is considered a promising target for the treatment of neuropsychiatric disorders.	phenethylamine	135-156	trace amine-associated receptor 1	Mus musculus	39-44
20832472-4	2010	Incubation of MAO-B with 2-phenylethylamine, an endogenous trace amine and MAO-B substrate, resulted in a progressive loss of enzyme activity, increased enzyme mass, distinct spectral changes and, as was observed with tranylcypromine, a parallel increase in high affinity binding of [(3)H]2-BFI.	phenethylamine	25-43	monoamine oxidase B	Homo sapiens	14-19
21971001-3	2011	In fact, while MAO-A has high affinity for serotonin and norepinephrine, MAO-B primarily serves the catabolism of 2-phenylethylamine (PEA) and contributes to the degradation of other trace amines and dopamine.	phenethylamine	114-132	monoamine oxidase B	Mus musculus	73-78
20832472-4	2010	Incubation of MAO-B with 2-phenylethylamine, an endogenous trace amine and MAO-B substrate, resulted in a progressive loss of enzyme activity, increased enzyme mass, distinct spectral changes and, as was observed with tranylcypromine, a parallel increase in high affinity binding of [(3)H]2-BFI.	phenethylamine	25-43	monoamine oxidase B	Homo sapiens	75-80
20406628-0	2010	Combined treatment with MAO-A inhibitor and MAO-B inhibitor increases extracellular noradrenaline levels more than MAO-A inhibitor alone through increases in beta-phenylethylamine.	phenethylamine	158-179	monoamine oxidase A	Rattus norvegicus	24-29
20073575-7	2010	As shown by enzyme assays using [14C]serotonin or [14C]beta-phenylethylamine as selective MAO-A or MAO-B substrates, MAO-A is largely predominant in MSCs.	phenethylamine	55-76	monoamine oxidase A	Homo sapiens	90-95
20073575-7	2010	As shown by enzyme assays using [14C]serotonin or [14C]beta-phenylethylamine as selective MAO-A or MAO-B substrates, MAO-A is largely predominant in MSCs.	phenethylamine	55-76	monoamine oxidase B	Homo sapiens	99-104
20073575-7	2010	As shown by enzyme assays using [14C]serotonin or [14C]beta-phenylethylamine as selective MAO-A or MAO-B substrates, MAO-A is largely predominant in MSCs.	phenethylamine	55-76	monoamine oxidase A	Homo sapiens	117-122
20406628-0	2010	Combined treatment with MAO-A inhibitor and MAO-B inhibitor increases extracellular noradrenaline levels more than MAO-A inhibitor alone through increases in beta-phenylethylamine.	phenethylamine	158-179	monoamine oxidase B	Rattus norvegicus	44-49
20406628-11	2010	Our results suggest that the combined treatment with a MAO-A inhibitor and a MAO-B inhibitor strengthens antidepressant effects because the combined treatment increases extracellular noradrenaline levels more than a MAO-A inhibitor alone through increases in beta-phenylethylamine.	phenethylamine	259-280	monoamine oxidase A	Rattus norvegicus	55-60
20406628-11	2010	Our results suggest that the combined treatment with a MAO-A inhibitor and a MAO-B inhibitor strengthens antidepressant effects because the combined treatment increases extracellular noradrenaline levels more than a MAO-A inhibitor alone through increases in beta-phenylethylamine.	phenethylamine	259-280	monoamine oxidase B	Rattus norvegicus	77-82
20217639-3	2010	The rank order of binding affinities was found to be the same for the subtypes tested (alpha(1A)-, alpha(2A)-, and alpha(2C)-AR) viz, 1R,2S-norephedrine > beta-phenethylamine > synephrine.	phenethylamine	158-177	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	87-95
20642018-2	2004	MAO-A preferentially oxidizes serotonin and noradrenaline, whereas MAO-B preferentially oxidizes phenethylamine.	phenethylamine	97-111	monoamine oxidase B	Homo sapiens	67-72
20590640-7	2010	In GTPgammaS-loaded neurones, the irreversibly-activated GIRK-current was still reversibly reduced by beta-PEA.	phenethylamine	102-110	potassium inwardly rectifying channel subfamily J member 3 S homeolog	Xenopus laevis	57-61
23908775-7	2010	Following subchronic administration to normal rats, rasagiline increases levels of dopamine in striatal microdialysate, possibly by the build-up of beta-phenylethylamine, which is an excellent substrate for MAO-B, and is an effective inhibitor of the plasma membrane dopamine transporter (DAT).	phenethylamine	148-169	monoamine oxidase B	Rattus norvegicus	207-212
20155805-8	2010	Other TAAR1 agonists including beta-phenylethylamine (beta-PEA), MDMA (3,4-methylenedioxymethamphetamine) and methamphetamine also induced significant, time-dependent thermoregulatory responses that were alike in WT and KO mice.	phenethylamine	31-52	trace amine-associated receptor 1	Mus musculus	6-11
20155805-8	2010	Other TAAR1 agonists including beta-phenylethylamine (beta-PEA), MDMA (3,4-methylenedioxymethamphetamine) and methamphetamine also induced significant, time-dependent thermoregulatory responses that were alike in WT and KO mice.	phenethylamine	54-62	trace amine-associated receptor 1	Mus musculus	6-11
20217639-6	2010	beta-Phenethylamine was more potent as an antagonist than 1R,2S-norephedrine and synephrine on the alpha(1A)-AR subtype.	phenethylamine	0-19	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	99-107
19875286-2	2009	Systematic chemical variations at the phenethylamine residue of these compounds lead to the discovery of compound 6m as potent, full agonist of the beta(2)-adrenoceptor with a high beta(1)/beta(2)-selectivity.	phenethylamine	38-52	beta-2 adrenergic receptor	Cavia porcellus	148-168
20067583-4	2010	One compound bearing two dopamine (DA)-like pharmacophoric "heads" separated by an 8-carbon linker achieved an 82-fold gain in inhibition of [(3)H] 2beta-carbomethoxy-3beta-(4-fluorophenyl)-tropane (CFT) binding compared with DA itself; bivalent compounds with a 6-carbon linker and heterologous combinations of DA-, amphetamine- and beta-phenethylamine-like heads all resulted in considerable and comparable gains in DAT affinity.	phenethylamine	334-353	solute carrier family 6 member 3	Homo sapiens	418-421
19883764-8	2010	Compared with human MAO A, rat MAO A oxidizes serotonin or kynuramine with twofold higher k(cat)/K(m) values, oxidizes phenethylamine with a 6.7-fold higher catalytic efficiency and benzylamine with a approximately 40-fold higher catalytic efficiency.	phenethylamine	119-133	monoamine oxidase A	Rattus norvegicus	31-36
19325074-6	2009	This receptor encoded by the human TAAR1 gene is also present in rat and mouse genomes (Taar1) and has been shown to be activated by endogenous trace amine ligands, including p-tyramine and beta-phenylethylamine.	phenethylamine	190-211	trace amine associated receptor 1	Homo sapiens	35-40
19482011-6	2009	TAAR1 activation by the common biogenic amines, the trace amine beta-phenylethylamine and methamphetamine alters the monoamine transporter function in both mouse and rhesus monkey brain synaptosomes, suggesting a modulatory role for this receptor in the presynaptic regulation of monoaminergic activity.	phenethylamine	64-85	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	117-138
19588076-3	2009	The preferred in vitro substrates of AOC2 were found to be 2-phenylethylamine, tryptamine and p-tyramine instead of methylamine and benzylamine, the favored substrates of AOC3.	phenethylamine	59-77	amine oxidase copper containing 2	Homo sapiens	37-41
19710633-1	2009	Monoamine oxidase (MAO) B catalyzes the degradation of beta-phenylethylamine (PEA), a trace amine neurotransmitter implicated in mood regulation.	phenethylamine	55-76	monoamine oxidase B	Mus musculus	0-25
19710633-1	2009	Monoamine oxidase (MAO) B catalyzes the degradation of beta-phenylethylamine (PEA), a trace amine neurotransmitter implicated in mood regulation.	phenethylamine	78-81	monoamine oxidase B	Mus musculus	0-25
19324062-4	2009	The present studies were designed to investigate the effects in rats of adenosine A(1) receptor activation/blockade on a behavior modulated by 5-HT(2A) receptor activation/blockade in the mPFC: head shakes induced in the rat by phenethylamine hallucinogens.	phenethylamine	228-242	adenosine A1 receptor	Rattus norvegicus	72-95
19324062-5	2009	An adenosine A(1) receptor agonist, N(6)-cyclohexyladenosine (CHA) suppressed head shakes induced by activation of 5-HT(2A) receptors with the phenethylamine hallucinogen (+/-)-2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI).	phenethylamine	143-157	adenosine A1 receptor	Rattus norvegicus	3-26
19519772-3	2009	The potency of p-tyramine and other non-catechols (d-amphetamine, beta-phenethylamine, MPP(+)) in inhibiting cocaine analog binding to DAT in digitonin-treated cells was markedly weakened to a level similar to that observed in cell-free membranes.	phenethylamine	66-85	solute carrier family 6 member 3	Homo sapiens	135-138
19325074-6	2009	This receptor encoded by the human TAAR1 gene is also present in rat and mouse genomes (Taar1) and has been shown to be activated by endogenous trace amine ligands, including p-tyramine and beta-phenylethylamine.	phenethylamine	190-211	trace amine-associated receptor 1	Mus musculus	88-93
18602830-0	2008	Structure-activity correlations for beta-phenethylamines at human trace amine receptor 1.	phenethylamine	36-56	trace amine associated receptor 1	Homo sapiens	66-88
19198157-2	2008	It has been established that MAO of mink, like MAO of rat, has properties of classic mammalian MAO: it deaminates tyramine, tryptamine, serotonin, benzilamine, beta-phenylethylamine and does not deaminate histamine as well as does not have sensitivity to semicarbazide.	phenethylamine	160-181	monoamine oxidase A	Rattus norvegicus	29-32
19198157-2	2008	It has been established that MAO of mink, like MAO of rat, has properties of classic mammalian MAO: it deaminates tyramine, tryptamine, serotonin, benzilamine, beta-phenylethylamine and does not deaminate histamine as well as does not have sensitivity to semicarbazide.	phenethylamine	160-181	monoamine oxidase A	Rattus norvegicus	47-50
19198157-2	2008	It has been established that MAO of mink, like MAO of rat, has properties of classic mammalian MAO: it deaminates tyramine, tryptamine, serotonin, benzilamine, beta-phenylethylamine and does not deaminate histamine as well as does not have sensitivity to semicarbazide.	phenethylamine	160-181	monoamine oxidase A	Rattus norvegicus	47-50
18652859-1	2008	Monoamine oxidases (MAOs) A and B are mitochondrial bound isoenzymes which catalyze the oxidative deamination of dietary amines and monoamine neurotransmitters, such as serotonin, norepinephrine, dopamine, beta-phenylethylamine and other trace amines.	phenethylamine	206-227	monoamine oxidase A	Mus musculus	0-33
18602830-1	2008	A cell line in which RD-HGA16 cells were stably transfected with the hTAAR 1 receptor was created and utilized to carry out a systematic evaluation of a series of beta-phenethylamines.	phenethylamine	163-183	trace amine associated receptor 1	Homo sapiens	69-76
20641420-2	2004	MAO-A preferentially oxidizes serotonin and noradrenaline, whereas MAO-B preferentially oxidizes phenethylamine.	phenethylamine	97-111	monoamine oxidase B	Homo sapiens	67-72
18182557-5	2008	In brain synaptosomes, beta-PEA significantly inhibited uptake and induced efflux of [3H]dopamine and [3H]serotonin in striatal and [3H]norepinephrine in thalamic synaptosomes of rhesus monkeys and wild-type mice, but it lacked the same effects in synaptosomes of TAAR1 knockout mice.	phenethylamine	23-31	trace amine-associated receptor 1	Mus musculus	264-269
18182557-8	2008	These results reveal that beta-PEA alters monoamine transporter function via interacting with TAAR1 but not monoamine autoreceptors.	phenethylamine	26-34	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	42-63
18182557-0	2008	Beta-phenylethylamine alters monoamine transporter function via trace amine-associated receptor 1: implication for modulatory roles of trace amines in brain.	phenethylamine	0-21	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	29-50
18182557-0	2008	Beta-phenylethylamine alters monoamine transporter function via trace amine-associated receptor 1: implication for modulatory roles of trace amines in brain.	phenethylamine	0-21	trace amine-associated receptor 1	Mus musculus	64-97
18182557-8	2008	These results reveal that beta-PEA alters monoamine transporter function via interacting with TAAR1 but not monoamine autoreceptors.	phenethylamine	26-34	trace amine-associated receptor 1	Mus musculus	94-99
18182557-4	2008	We confirmed that TAAR1 was activated by trace amines and demonstrated that TAAR1 activation by beta-PEA significantly inhibited uptake and induced efflux of [3H]dopamine, [3H]norepinephrine, and [3H]serotonin in transfected cells.	phenethylamine	96-104	trace amine-associated receptor 1	Mus musculus	18-23
18182557-4	2008	We confirmed that TAAR1 was activated by trace amines and demonstrated that TAAR1 activation by beta-PEA significantly inhibited uptake and induced efflux of [3H]dopamine, [3H]norepinephrine, and [3H]serotonin in transfected cells.	phenethylamine	96-104	trace amine-associated receptor 1	Mus musculus	76-81
17715398-2	2007	Using the ergoline lysergic acid diethylamide (LSD), and a series of substituted tryptamine and phenethylamine 5-HT(2A) receptor agonists, we found that Ser5.43(239) is more critical for agonist binding and function than Ser5.46(242).	phenethylamine	96-110	5-hydroxytryptamine receptor 2A	Homo sapiens	111-128
17900709-1	2007	Trace amines such as tyramine, octopamine and beta-phenylethylamine bind with high affinity to the mammalian trace amine-associated receptor 1 (Taar1), potentially activating G-proteins in the synaptic membranes of target neurons.	phenethylamine	46-67	trace amine associated receptor 1	Homo sapiens	109-142
17900709-1	2007	Trace amines such as tyramine, octopamine and beta-phenylethylamine bind with high affinity to the mammalian trace amine-associated receptor 1 (Taar1), potentially activating G-proteins in the synaptic membranes of target neurons.	phenethylamine	46-67	trace amine associated receptor 1	Homo sapiens	144-149
17177891-0	2006	Alternate binding mode of C-terminal phenethylamine analogs of G(t)alpha(340-350) to photoactivated rhodopsin.	phenethylamine	37-51	rhodopsin	Homo sapiens	100-109
17218486-2	2007	Recently, it was reported that METH, AMPH, POHA, and the TAs para-tyramine (TYR) and beta-phenylethylamine (PEA) stimulate cAMP production in human embryonic kidney (HEK)-293 cells expressing rat trace amine-associated receptor 1 (rTAAR1).	phenethylamine	85-106	trace-amine-associated receptor 1	Rattus norvegicus	196-229
17218486-2	2007	Recently, it was reported that METH, AMPH, POHA, and the TAs para-tyramine (TYR) and beta-phenylethylamine (PEA) stimulate cAMP production in human embryonic kidney (HEK)-293 cells expressing rat trace amine-associated receptor 1 (rTAAR1).	phenethylamine	85-106	trace-amine-associated receptor 1	Rattus norvegicus	231-237
17218486-2	2007	Recently, it was reported that METH, AMPH, POHA, and the TAs para-tyramine (TYR) and beta-phenylethylamine (PEA) stimulate cAMP production in human embryonic kidney (HEK)-293 cells expressing rat trace amine-associated receptor 1 (rTAAR1).	phenethylamine	108-111	trace-amine-associated receptor 1	Rattus norvegicus	196-229
17218486-2	2007	Recently, it was reported that METH, AMPH, POHA, and the TAs para-tyramine (TYR) and beta-phenylethylamine (PEA) stimulate cAMP production in human embryonic kidney (HEK)-293 cells expressing rat trace amine-associated receptor 1 (rTAAR1).	phenethylamine	108-111	trace-amine-associated receptor 1	Rattus norvegicus	231-237
17067556-0	2007	Identification of monoamine oxidase and cytochrome P450 isoenzymes involved in the deamination of phenethylamine-derived designer drugs (2C-series).	phenethylamine	98-112	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	40-55
16376544-0	2006	The reversed binding of beta-phenethylamine inhibitors of DPP-IV: X-ray structures and properties of novel fragment and elaborated inhibitors.	phenethylamine	24-43	dipeptidyl peptidase 4	Homo sapiens	58-64
16352699-3	2006	Brain levels of dopamine and beta-phenylethylamine (beta-PEA), a behaviorally active endogenous trace amine, increase after (R)-(-)-deprenyl treatment due to MAO-B blockade and (R)-(-)-deprenyl is metabolized to (R)-(-)-methamphetamine and (R)-(-)-amphetamine, suggesting that (R)-(-)-deprenyl may have psychostimulant-like behavioral effects.	phenethylamine	29-50	monoamine oxidase B	Rattus norvegicus	158-163
16352699-3	2006	Brain levels of dopamine and beta-phenylethylamine (beta-PEA), a behaviorally active endogenous trace amine, increase after (R)-(-)-deprenyl treatment due to MAO-B blockade and (R)-(-)-deprenyl is metabolized to (R)-(-)-methamphetamine and (R)-(-)-amphetamine, suggesting that (R)-(-)-deprenyl may have psychostimulant-like behavioral effects.	phenethylamine	52-60	monoamine oxidase B	Rattus norvegicus	158-163
16376544-2	2006	This finding provided the basis for a general hypothesis of a reverse binding mode for beta-phenethylamine-based DPP-IV inhibitors.	phenethylamine	87-106	dipeptidyl peptidase 4	Homo sapiens	113-119
16376544-1	2006	The co-crystal structure of beta-phenethylamine fragment inhibitor 5 bound to DPP-IV revealed that the phenyl ring occupied the proline pocket of the enzyme.	phenethylamine	28-47	dipeptidyl peptidase 4	Homo sapiens	78-84
15569272-3	2004	Metabolism of 2-phenylethylamine to phenylacetaldehyde is catalysed by monoamine oxidase B but the oxidation to its acid is usually ascribed to aldehyde dehydrogenase and the contribution of aldehyde oxidase and xanthine oxidase, if any, is ignored.	phenethylamine	14-32	monoamine oxidase B	Homo sapiens	71-90
16277614-1	2005	Experiments compared a series of phenethylamine hallucinogens with their phenylisopropylamine analogues for binding affinity and ability to stimulate serotonin 5-HT 2A receptor-mediated hydrolysis of phosphatidyl inositol in cells expressing cloned rat and human 5-HT 2A receptors.	phenethylamine	33-47	5-hydroxytryptamine receptor 2A	Homo sapiens	160-167
16277614-2	2005	The (+/-)phenylisopropylamine analogues had significantly higher intrinsic activities for 5-HT 2A receptor-mediated hydrolysis of phosphatidyl inositol compared to their phenethylamine analogues.	phenethylamine	170-184	5-hydroxytryptamine receptor 2A	Homo sapiens	90-97
16277614-5	2005	In conclusion, our data support the hypothesis that phenylisopropylamines have higher hallucinogenic potency than their phenethylamine analogues primarily because they have higher intrinsic activities at 5-HT 2A receptors.	phenethylamine	120-134	5-hydroxytryptamine receptor 2A	Homo sapiens	204-211
16122767-1	2005	In heterologous cells expressing the dopamine transporter (DAT), simultaneous elevation of intracellular Na(+) and depolarization of the membrane with gramicidin reduced the potency of various DAT substrates, including dopamine, d-amphetamine, beta-phenethylamine, p-tyramine, and MPP(+), in inhibiting binding of the cocaine analog [(3)H]CFT, with the greatest reduction observed for d-amphetamine.	phenethylamine	244-263	solute carrier family 6 member 3	Rattus norvegicus	37-57
16122767-1	2005	In heterologous cells expressing the dopamine transporter (DAT), simultaneous elevation of intracellular Na(+) and depolarization of the membrane with gramicidin reduced the potency of various DAT substrates, including dopamine, d-amphetamine, beta-phenethylamine, p-tyramine, and MPP(+), in inhibiting binding of the cocaine analog [(3)H]CFT, with the greatest reduction observed for d-amphetamine.	phenethylamine	244-263	solute carrier family 6 member 3	Rattus norvegicus	59-62
16122767-1	2005	In heterologous cells expressing the dopamine transporter (DAT), simultaneous elevation of intracellular Na(+) and depolarization of the membrane with gramicidin reduced the potency of various DAT substrates, including dopamine, d-amphetamine, beta-phenethylamine, p-tyramine, and MPP(+), in inhibiting binding of the cocaine analog [(3)H]CFT, with the greatest reduction observed for d-amphetamine.	phenethylamine	244-263	solute carrier family 6 member 3	Rattus norvegicus	193-196
15972234-2	2005	The objective of the present study was to determine the neuroanatomical location of the 5HT2A receptors which may be responsible for the stimulus effects of the phenethylamine hallucinogen [-]2,5-dimethoxy-4-methylamphetamine (DOM).	phenethylamine	161-175	5-hydroxytryptamine receptor 2A	Rattus norvegicus	88-93
15900211-7	2005	These results demonstrate that the A1 allele of DRD2 gene is associated with increased striatal activity of aromatic L-amino acid decarboxylase, the final enzyme in the biosynthesis of dopamine and the rate-limiting enzyme for trace amine (e.g. beta-phenylethylamine) synthesis.	phenethylamine	245-266	dopamine receptor D2	Homo sapiens	48-52
15900211-7	2005	These results demonstrate that the A1 allele of DRD2 gene is associated with increased striatal activity of aromatic L-amino acid decarboxylase, the final enzyme in the biosynthesis of dopamine and the rate-limiting enzyme for trace amine (e.g. beta-phenylethylamine) synthesis.	phenethylamine	245-266	dopa decarboxylase	Homo sapiens	108-143
15569272-3	2004	Metabolism of 2-phenylethylamine to phenylacetaldehyde is catalysed by monoamine oxidase B but the oxidation to its acid is usually ascribed to aldehyde dehydrogenase and the contribution of aldehyde oxidase and xanthine oxidase, if any, is ignored.	phenethylamine	14-32	aldehyde oxidase 1	Homo sapiens	191-207
15388968-1	2004	Aromatic amine dehydrogenase was purified and characterized from Alcaligenes xylosoxidans IFO13495 grown on beta-phenylethylamine.	phenethylamine	108-129	ABC transporter substrate-binding protein	Achromobacter xylosoxidans	15-28
15351283-1	2004	A simple and selective assay for the evaluation of in vivo inhibition of rat brain monoamine oxidases (MAO) A and B following a single dose of MAO inhibitors was developed through the simultaneous determination of endogenous 5-hydroxy tryptamine, 5-hydroxyindole-3-acetic acid (5-HIAA), tryptophane, and 2-phenethylamine (PEA) in rat brain using liquid chromatography-tandem mass spectrometry (LC/MS/MS).	phenethylamine	304-320	monoamine oxidase A	Rattus norvegicus	83-115
15351283-1	2004	A simple and selective assay for the evaluation of in vivo inhibition of rat brain monoamine oxidases (MAO) A and B following a single dose of MAO inhibitors was developed through the simultaneous determination of endogenous 5-hydroxy tryptamine, 5-hydroxyindole-3-acetic acid (5-HIAA), tryptophane, and 2-phenethylamine (PEA) in rat brain using liquid chromatography-tandem mass spectrometry (LC/MS/MS).	phenethylamine	304-320	monoamine oxidase A	Rattus norvegicus	103-106
15351283-1	2004	A simple and selective assay for the evaluation of in vivo inhibition of rat brain monoamine oxidases (MAO) A and B following a single dose of MAO inhibitors was developed through the simultaneous determination of endogenous 5-hydroxy tryptamine, 5-hydroxyindole-3-acetic acid (5-HIAA), tryptophane, and 2-phenethylamine (PEA) in rat brain using liquid chromatography-tandem mass spectrometry (LC/MS/MS).	phenethylamine	322-325	monoamine oxidase A	Rattus norvegicus	83-115
15351283-1	2004	A simple and selective assay for the evaluation of in vivo inhibition of rat brain monoamine oxidases (MAO) A and B following a single dose of MAO inhibitors was developed through the simultaneous determination of endogenous 5-hydroxy tryptamine, 5-hydroxyindole-3-acetic acid (5-HIAA), tryptophane, and 2-phenethylamine (PEA) in rat brain using liquid chromatography-tandem mass spectrometry (LC/MS/MS).	phenethylamine	322-325	monoamine oxidase A	Rattus norvegicus	103-106
15447669-2	2004	It is believed that the locomotor-stimulating action of beta-PEA, much like amphetamine, depends on its ability to increase extracellular dopamine (DA) concentrations owing to reversal of the direction of dopamine transporter (DAT)-mediated DA transport.	phenethylamine	56-64	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	227-230
15447669-5	2004	In microdialysis studies, beta-PEA, administered either systemically or locally via intrastriatal infusion, produced a pronounced outflow of striatal DA in WT mice whereas no increase was detected in mice lacking the DAT (DAT-KO mice).	phenethylamine	26-34	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	217-220
15447669-5	2004	In microdialysis studies, beta-PEA, administered either systemically or locally via intrastriatal infusion, produced a pronounced outflow of striatal DA in WT mice whereas no increase was detected in mice lacking the DAT (DAT-KO mice).	phenethylamine	26-34	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	222-233
15447669-8	2004	In DAT-KO mice, whose locomotor activity and stereotypy are increased in a novel environment, beta-PEA (10-100 mg/kg) exerted a potent inhibitory action.	phenethylamine	94-102	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	3-6
15447669-9	2004	At high doses, beta-PEA induced stereotypies in WT and heterozygous mice; some manifestations of stereotypy were also observed in the DAT-KO mice.	phenethylamine	15-23	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	134-137
14697876-10	2004	MAO-A oxidizes noradrenaline and serotonin; and MAO-B, mainly beta-phenylethylamine.	phenethylamine	62-83	monoamine oxidase B	Homo sapiens	48-53
15103693-4	2004	DA, Hill coefficient 1.0, and its analogs 3-hydroxyphenethylamine and 4-hydroxyphenethylamine attenuated the effects of PG on the DAT while phenethylamine did not.	phenethylamine	51-65	solute carrier family 6 member 3	Rattus norvegicus	130-133
12970383-2	2003	The SSAO substrates benzylamine, phenethylamine, and methylamine potentiate the hypotensive response to HYD.	phenethylamine	33-47	amine oxidase, copper containing 3	Rattus norvegicus	4-8
14667216-0	2003	Rational design of an indolebutanoic acid derivative as a novel aldose reductase inhibitor based on docking and 3D QSAR studies of phenethylamine derivatives.	phenethylamine	131-145	aldo-keto reductase family 1 member B	Sus scrofa	64-80
14667216-1	2003	A series of 45 phenethylamine derivatives were synthesized and evaluated for their inhibitory activity against pig kidney aldose reductase (ALR2, EC 1.1.1.21).	phenethylamine	15-29	aldo-keto reductase family 1 member B	Sus scrofa	122-138
14667216-1	2003	A series of 45 phenethylamine derivatives were synthesized and evaluated for their inhibitory activity against pig kidney aldose reductase (ALR2, EC 1.1.1.21).	phenethylamine	15-29	aldo-keto reductase family 1 member B	Sus scrofa	140-144
14667216-4	2003	The results indicated that phenethylamine derivatives nicely fit into the active pocket of ALR2 by forming various hydrogen bonding and hydrophobic interactions.	phenethylamine	27-41	aldo-keto reductase family 1 member B	Homo sapiens	91-95
14667216-8	2003	This rationally designed compound exhibits an ALR2 inhibition with an IC(50) value of 7.4 microM, which compares favorably to that of a well-known ALR2 inhibitor, tolrestat (IC(50) = 16 microM) and represents a potency approximately 240-fold higher than that of an original phenethylamine lead compound, YUA001.	phenethylamine	274-288	aldo-keto reductase family 1 member B	Homo sapiens	46-50
14667216-8	2003	This rationally designed compound exhibits an ALR2 inhibition with an IC(50) value of 7.4 microM, which compares favorably to that of a well-known ALR2 inhibitor, tolrestat (IC(50) = 16 microM) and represents a potency approximately 240-fold higher than that of an original phenethylamine lead compound, YUA001.	phenethylamine	274-288	aldo-keto reductase family 1 member B	Homo sapiens	147-151
14628189-4	2003	Inhibition of monoamine-oxidase type B (MAO-B) and monoamine oxidase type A (MAO-A) activity was determined by measurement of as beta-phenylethylamine (PEA) by GCMS and 5-hydroxyindoleacetic acid (5-HIAA) by High Performance Liquid Chromatography (HPLC) assays.	phenethylamine	129-150	monoamine oxidase B	Homo sapiens	14-38
14628189-4	2003	Inhibition of monoamine-oxidase type B (MAO-B) and monoamine oxidase type A (MAO-A) activity was determined by measurement of as beta-phenylethylamine (PEA) by GCMS and 5-hydroxyindoleacetic acid (5-HIAA) by High Performance Liquid Chromatography (HPLC) assays.	phenethylamine	129-150	monoamine oxidase A	Homo sapiens	51-75
14628189-4	2003	Inhibition of monoamine-oxidase type B (MAO-B) and monoamine oxidase type A (MAO-A) activity was determined by measurement of as beta-phenylethylamine (PEA) by GCMS and 5-hydroxyindoleacetic acid (5-HIAA) by High Performance Liquid Chromatography (HPLC) assays.	phenethylamine	129-150	monoamine oxidase A	Homo sapiens	77-82
14628189-4	2003	Inhibition of monoamine-oxidase type B (MAO-B) and monoamine oxidase type A (MAO-A) activity was determined by measurement of as beta-phenylethylamine (PEA) by GCMS and 5-hydroxyindoleacetic acid (5-HIAA) by High Performance Liquid Chromatography (HPLC) assays.	phenethylamine	152-155	monoamine oxidase B	Homo sapiens	14-38
14628189-4	2003	Inhibition of monoamine-oxidase type B (MAO-B) and monoamine oxidase type A (MAO-A) activity was determined by measurement of as beta-phenylethylamine (PEA) by GCMS and 5-hydroxyindoleacetic acid (5-HIAA) by High Performance Liquid Chromatography (HPLC) assays.	phenethylamine	152-155	monoamine oxidase B	Homo sapiens	40-45
14628189-4	2003	Inhibition of monoamine-oxidase type B (MAO-B) and monoamine oxidase type A (MAO-A) activity was determined by measurement of as beta-phenylethylamine (PEA) by GCMS and 5-hydroxyindoleacetic acid (5-HIAA) by High Performance Liquid Chromatography (HPLC) assays.	phenethylamine	152-155	monoamine oxidase A	Homo sapiens	51-75
14628189-4	2003	Inhibition of monoamine-oxidase type B (MAO-B) and monoamine oxidase type A (MAO-A) activity was determined by measurement of as beta-phenylethylamine (PEA) by GCMS and 5-hydroxyindoleacetic acid (5-HIAA) by High Performance Liquid Chromatography (HPLC) assays.	phenethylamine	152-155	monoamine oxidase A	Homo sapiens	77-82
11979502-4	2002	Enzymic activity was measured with a radiochemical method using serotonin and beta-phenylethylamine as preferential substrates for MAO A and MAO B, respectively.	phenethylamine	78-99	monoamine oxidase A	Gallus gallus	131-136
12746108-4	2003	The method was used to test inhibition of human and mouse CYP2A enzymes by three phenylethylamine derivatives 2-(p-tolyl)-ethylamine, amphetamine, 2-phenylethylamine and benzaldehyde, and two of its derivatives, 4-methylbenzaldehyde and 4-methoxybenzaldehyde.	phenethylamine	147-165	cytochrome P450, family 2, subfamily a	Mus musculus	58-63
12746108-9	2003	Amphetamine is a weak inhibitor of CYP2A6, whereas benzaldehyde is a suicide inhibitor with K(inact) = 0.16 min(-1) and K(I) = 18 micro M. The K(ic) values of 2-phenylethylamine, 2-(p-tolyl)-ethylamine, 4-methylbenzaldehyde and 4-methoxybenzaldehyde were 1.13, 0.23, 0.36 and 0.73 micro M for CYP2A6, respectively.	phenethylamine	159-177	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	293-299
12818349-2	2003	beta-phenylethylamine (beta-PEA) has always been considered the "endogenous" substrate of MAO B.	phenethylamine	0-21	monoamine oxidase B	Rattus norvegicus	90-95
12818349-2	2003	beta-phenylethylamine (beta-PEA) has always been considered the "endogenous" substrate of MAO B.	phenethylamine	23-31	monoamine oxidase B	Rattus norvegicus	90-95
12818349-3	2003	We thought worthwide to evaluate the effect of Ro 41-1049 and lazabemide, both members of a class of highly selective, mechanism-based and reversible inhibitors for MAO-A and MAO B, respectively on the metabolization of beta-PEA by the rat heart.	phenethylamine	220-228	monoamine oxidase A	Rattus norvegicus	165-170
12818349-3	2003	We thought worthwide to evaluate the effect of Ro 41-1049 and lazabemide, both members of a class of highly selective, mechanism-based and reversible inhibitors for MAO-A and MAO B, respectively on the metabolization of beta-PEA by the rat heart.	phenethylamine	220-228	monoamine oxidase B	Rattus norvegicus	175-180
12818349-6	2003	Unexpectedly, the selective MAO-A inhibitor Ro 41-1049 was by far the most potent inhibitor of beta-PEA (20 microM) deamination in the rat heart, while clorgyline, another MAO A inhibitor, and lazabemide, a MAO B inhibitor, had intermediate efficacy; selegiline was found unable to inhibit deamination of beta-PEA.	phenethylamine	95-103	monoamine oxidase A	Rattus norvegicus	28-33
12818349-6	2003	Unexpectedly, the selective MAO-A inhibitor Ro 41-1049 was by far the most potent inhibitor of beta-PEA (20 microM) deamination in the rat heart, while clorgyline, another MAO A inhibitor, and lazabemide, a MAO B inhibitor, had intermediate efficacy; selegiline was found unable to inhibit deamination of beta-PEA.	phenethylamine	305-313	monoamine oxidase A	Rattus norvegicus	28-33
12625872-0	2003	Binding and functional affinity of some newly synthesized phenethylamine and phenoxypropanolamine derivatives for their agonistic activity at recombinant human beta3-adrenoceptor.	phenethylamine	58-72	adrenoceptor beta 3	Homo sapiens	160-178
11979502-4	2002	Enzymic activity was measured with a radiochemical method using serotonin and beta-phenylethylamine as preferential substrates for MAO A and MAO B, respectively.	phenethylamine	78-99	monoamine oxidase B	Gallus gallus	141-146
11812236-7	2002	The steady-state kinetic properties of P. pastoris-expressed MAO-A are similar to those of S. cerevisiae-expressed MAO-A using the following substrates: phenethylamine, p-CF(3)-benzylamine, dopamine, serotonin, and kynuramine.	phenethylamine	153-167	monoamine oxidase A	Homo sapiens	61-66
12039419-0	2002	Rat striatal monoamine oxidase-B inhibition by l-deprenyl and rasagiline: its relationship to 2-phenylethylamine-induced stereotypy and Parkinson"s disease.	phenethylamine	94-112	monoamine oxidase B	Rattus norvegicus	13-32
11812236-7	2002	The steady-state kinetic properties of P. pastoris-expressed MAO-A are similar to those of S. cerevisiae-expressed MAO-A using the following substrates: phenethylamine, p-CF(3)-benzylamine, dopamine, serotonin, and kynuramine.	phenethylamine	153-167	monoamine oxidase A	Homo sapiens	115-120
11797065-1	2001	RATIONALE AND OBJECTIVE: Sufficiently high doses of beta-phenylethylamine (beta-PEA), a trace amine that is rapidly metabolized by monoamine oxidase-type B (MAO-B), can produce effects comparable to those of cocaine or methamphetamine (MA).	phenethylamine	52-73	monoamine oxidase B	Homo sapiens	131-155
11797065-1	2001	RATIONALE AND OBJECTIVE: Sufficiently high doses of beta-phenylethylamine (beta-PEA), a trace amine that is rapidly metabolized by monoamine oxidase-type B (MAO-B), can produce effects comparable to those of cocaine or methamphetamine (MA).	phenethylamine	52-73	monoamine oxidase B	Homo sapiens	157-162
11797065-1	2001	RATIONALE AND OBJECTIVE: Sufficiently high doses of beta-phenylethylamine (beta-PEA), a trace amine that is rapidly metabolized by monoamine oxidase-type B (MAO-B), can produce effects comparable to those of cocaine or methamphetamine (MA).	phenethylamine	75-83	monoamine oxidase B	Homo sapiens	131-155
11797065-1	2001	RATIONALE AND OBJECTIVE: Sufficiently high doses of beta-phenylethylamine (beta-PEA), a trace amine that is rapidly metabolized by monoamine oxidase-type B (MAO-B), can produce effects comparable to those of cocaine or methamphetamine (MA).	phenethylamine	75-83	monoamine oxidase B	Homo sapiens	157-162
11134050-5	2001	Mutant MAO A-I335Y became like MAO B, which exhibits a higher preference for beta-phenylethylamine than for the MAO A preferred substrate serotonin (5-hydroxytryptamine), and became more sensitive to deprenyl (MAO B-specific inhibitor) than to clorgyline (MAO A-specific inhibitor).	phenethylamine	77-98	monoamine oxidase A	Homo sapiens	7-12
11714275-0	2001	Oxidation of phenethylamine derivatives by cytochrome P450 2D6: the issue of substrate protonation in binding and catalysis.	phenethylamine	13-27	cytochrome P450 2D6	Homo sapiens	43-62
11549462-2	2001	Affinity data at A1AR, A2AAR and A3AR in bovine membranes show that these new compounds bind the A1AR in a selective way over A2AAR and A3AR and one of them (3j) presents a very high affinity, probably due to the phenethylamine substituent at C-4.	phenethylamine	213-227	complement C4	Bos taurus	243-246
11134050-6	2001	The reciprocal mutant MAO B-Y326I exhibited an increased preference for 5-hydroxytryptamine, a decreased preference for beta-phenylethylamine, and, similar to MAO A, was more sensitive to clorgyline than to deprenyl.	phenethylamine	120-141	monoamine oxidase B	Homo sapiens	22-27
11134050-5	2001	Mutant MAO A-I335Y became like MAO B, which exhibits a higher preference for beta-phenylethylamine than for the MAO A preferred substrate serotonin (5-hydroxytryptamine), and became more sensitive to deprenyl (MAO B-specific inhibitor) than to clorgyline (MAO A-specific inhibitor).	phenethylamine	77-98	monoamine oxidase B	Homo sapiens	31-36
11160474-1	2001	OBJECTIVE: To evaluate the correlation between changes in platelet monoamine oxidase type B (MAO-B) activity and plasma beta-phenylethylamine (PEA) concentrations in patients with Parkinson"s disease and controls.	phenethylamine	120-141	monoamine oxidase B	Homo sapiens	67-91
11245847-3	2001	Immunoblots and enzyme assays, performed using [14C]5-hydroxytriptamine and [14C]beta-phenylethylamine as substrates for monoamine oxidases-A and -B, respectively, showed that monoamine oxidase-A is the isoenzyme largely predominant in 9-day-old rats renal cortex.	phenethylamine	81-102	monoamine oxidase A	Rattus norvegicus	121-148
11245847-3	2001	Immunoblots and enzyme assays, performed using [14C]5-hydroxytriptamine and [14C]beta-phenylethylamine as substrates for monoamine oxidases-A and -B, respectively, showed that monoamine oxidase-A is the isoenzyme largely predominant in 9-day-old rats renal cortex.	phenethylamine	81-102	monoamine oxidase A	Rattus norvegicus	176-195
11160474-1	2001	OBJECTIVE: To evaluate the correlation between changes in platelet monoamine oxidase type B (MAO-B) activity and plasma beta-phenylethylamine (PEA) concentrations in patients with Parkinson"s disease and controls.	phenethylamine	120-141	monoamine oxidase B	Homo sapiens	93-98
11160474-1	2001	OBJECTIVE: To evaluate the correlation between changes in platelet monoamine oxidase type B (MAO-B) activity and plasma beta-phenylethylamine (PEA) concentrations in patients with Parkinson"s disease and controls.	phenethylamine	143-146	monoamine oxidase B	Homo sapiens	67-91
11160474-1	2001	OBJECTIVE: To evaluate the correlation between changes in platelet monoamine oxidase type B (MAO-B) activity and plasma beta-phenylethylamine (PEA) concentrations in patients with Parkinson"s disease and controls.	phenethylamine	143-146	monoamine oxidase B	Homo sapiens	93-98
11027922-4	2000	Administration of the mGlu2/3 agonist LY354740 (0.3-10 mg/kg, ip) suppressed head shakes induced by the phenethylamine hallucinogen 1-(2, 5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI).	phenethylamine	104-118	glutamate receptor, metabotropic 3	Mus musculus	22-29
11106506-0	2000	Structure-activity relations in the oxidation of phenethylamine analogues by recombinant human liver monoamine oxidase A.	phenethylamine	49-63	monoamine oxidase A	Homo sapiens	101-120
11106506-1	2000	The interaction of recombinant human liver monoamine oxidase A (MAO A) with a series of phenethylamine substrate analogues has been investigated by steady-state and stopped-flow kinetic techniques.	phenethylamine	88-102	monoamine oxidase A	Homo sapiens	43-62
11106506-1	2000	The interaction of recombinant human liver monoamine oxidase A (MAO A) with a series of phenethylamine substrate analogues has been investigated by steady-state and stopped-flow kinetic techniques.	phenethylamine	88-102	monoamine oxidase A	Homo sapiens	64-69
11106506-5	2000	Phenethylamine oxidation by MAO A can be described as the C-H bond cleavage step being rate limiting in catalysis and with oxygen reacting with the reduced enzyme-imine complex.	phenethylamine	0-14	monoamine oxidase A	Homo sapiens	28-33
11106506-7	2000	The binding affinities of a series of para-substituted phenethylamine analogues to MAO A show an increase in affinity of the deprotonated amine with increasing van der Waals volume of the substituent.	phenethylamine	55-69	monoamine oxidase A	Homo sapiens	83-88
10926841-3	2000	We found that several SSAO substrates (benzylamine, tyramine, methylamine, n-decylamine, histamine, tryptamine or beta-phenylethylamine), in combination with low concentrations of vanadate, stimulate glucose transport in isolated rat adipocytes.	phenethylamine	114-135	amine oxidase, copper containing 3	Rattus norvegicus	22-26
10936214-3	2000	When compared with MAO A, MAO A-F208I showed a sixfold decrease in the specificity constant k(cat)/K(m) for both the MAO A- and the MAO B-preferring substrates 5-hydroxytryptamine and beta-phenylethylamine, respectively.	phenethylamine	184-205	monoamine oxidase A	Homo sapiens	26-31
10936214-3	2000	When compared with MAO A, MAO A-F208I showed a sixfold decrease in the specificity constant k(cat)/K(m) for both the MAO A- and the MAO B-preferring substrates 5-hydroxytryptamine and beta-phenylethylamine, respectively.	phenethylamine	184-205	monoamine oxidase A	Homo sapiens	26-31
10936214-3	2000	When compared with MAO A, MAO A-F208I showed a sixfold decrease in the specificity constant k(cat)/K(m) for both the MAO A- and the MAO B-preferring substrates 5-hydroxytryptamine and beta-phenylethylamine, respectively.	phenethylamine	184-205	monoamine oxidase B	Homo sapiens	132-137
10897801-4	1999	MAO-A and MAO-B activities were estimated with radioassays employing serotonin and beta-phenylethylamine, respectively and specific inhibitors, clorgyline and deprenyl.	phenethylamine	83-104	monoamine oxidase A	Rattus norvegicus	0-5
11061211-2	2000	This effect could be the result of increased endogenous levels of the MAO-B substrate beta-phenylethylamine, which is both a releaser of dopamine as well as an inhibitor of the neuronal membrane active dopamine uptake.	phenethylamine	86-107	monoamine oxidase B	Rattus norvegicus	70-75
10504491-3	1999	METHODS: MAOs were characterized in membrane preparations and intact mesangial cells by enzyme assay using [14C]5-hydroxytryptamine and [14C]beta-phenylethylamine as specific substrates for MAO-A and MAO-B, respectively, and by Western blot analysis.	phenethylamine	141-162	monoamine oxidase A	Rattus norvegicus	190-195
10504491-3	1999	METHODS: MAOs were characterized in membrane preparations and intact mesangial cells by enzyme assay using [14C]5-hydroxytryptamine and [14C]beta-phenylethylamine as specific substrates for MAO-A and MAO-B, respectively, and by Western blot analysis.	phenethylamine	141-162	monoamine oxidase B	Rattus norvegicus	200-205
10510170-6	1999	We conclude that phenethylamine and indoleamine hallucinogens may exert their hallucinogenic effect by interacting with 5-HT2A receptors via a Ca2+/CaM-KII-dependent signal transduction pathway as partial agonists and modulating the NMDA receptors-mediated sensory, perceptual, affective and cognitive processes.	phenethylamine	17-31	5-hydroxytryptamine receptor 2A	Rattus norvegicus	120-126
10889538-2	2000	AADC does not catalyse the rate limiting step in either pathway, but is rate limiting in the synthesis of 2-phenylethylamine (2PE) which is a positive modulator of dopaminergic transmission and a candidate natural psychotogenic compound.1 We and others have proposed that polymorphism in AADC resulting in altered 2PE activity might contribute to the pathogenesis of psychosis.	phenethylamine	106-124	dopa decarboxylase	Homo sapiens	0-4
10889538-2	2000	AADC does not catalyse the rate limiting step in either pathway, but is rate limiting in the synthesis of 2-phenylethylamine (2PE) which is a positive modulator of dopaminergic transmission and a candidate natural psychotogenic compound.1 We and others have proposed that polymorphism in AADC resulting in altered 2PE activity might contribute to the pathogenesis of psychosis.	phenethylamine	106-124	dopa decarboxylase	Homo sapiens	288-292
10037500-0	1999	Effects of methylphenidate analogues on phenethylamine substrates for the striatal dopamine transporter: potential as amphetamine antagonists?	phenethylamine	40-54	solute carrier family 6 member 3	Homo sapiens	83-103
10193780-15	1999	The results suggest that a reversible inhibition of dopamine uptake occurs following chronic low dose selegiline treatment in vivo which may be mediated by an increase in endogenous MAO-B substrates such as 2-phenylethylamine, rather than by the inhibitor molecule or its metabolites.	phenethylamine	207-225	monoamine oxidase B	Rattus norvegicus	182-187
10897801-4	1999	MAO-A and MAO-B activities were estimated with radioassays employing serotonin and beta-phenylethylamine, respectively and specific inhibitors, clorgyline and deprenyl.	phenethylamine	83-104	monoamine oxidase B	Rattus norvegicus	10-15
9682221-4	1998	The levels of MAo and B were assayed: MAO A showed a K(m) of 137.1 +/- 16.2 microM and a V(m) of 10.4 +/- 2.5 nmol mg-1 min-1 for serotonin; MAo B had a K(m) of 9.9 +/- 1.6 microM and V(m) of 4.3 +/- 1.1 nmol mg-1 min-1 for beta-phenylethylamine (mean +/- SE of seven hearts).	phenethylamine	224-245	monoamine oxidase A	Homo sapiens	38-43
9682221-4	1998	The levels of MAo and B were assayed: MAO A showed a K(m) of 137.1 +/- 16.2 microM and a V(m) of 10.4 +/- 2.5 nmol mg-1 min-1 for serotonin; MAo B had a K(m) of 9.9 +/- 1.6 microM and V(m) of 4.3 +/- 1.1 nmol mg-1 min-1 for beta-phenylethylamine (mean +/- SE of seven hearts).	phenethylamine	224-245	CD59 molecule (CD59 blood group)	Homo sapiens	120-125
9316835-1	1997	The biogenic amine phenethylamine has been shown to be N-oxygenated by human flavin-containing monooxygenase (FMO) (form 3) and human liver microsomes and, to a much lesser extent, N-oxygenated by porcine liver FMO1 and porcine liver microsomes but not by rabbit FMO2.	phenethylamine	19-33	flavin containing dimethylaniline monoxygenase 1	Homo sapiens	211-215
9610921-4	1998	In an attempt to determine some of the biochemical changes in striatal dopaminergic neurotransmission that could contribute to REM sleep deprivation effects, we measured the activity of monoamine oxidase (MAO) A and B, the enzymes responsible for dopamine and beta-phenylethylamine (beta-PEA) deamination in striatum.	phenethylamine	260-281	monoamine oxidase A	Rattus norvegicus	186-217
9610921-4	1998	In an attempt to determine some of the biochemical changes in striatal dopaminergic neurotransmission that could contribute to REM sleep deprivation effects, we measured the activity of monoamine oxidase (MAO) A and B, the enzymes responsible for dopamine and beta-phenylethylamine (beta-PEA) deamination in striatum.	phenethylamine	283-291	monoamine oxidase A	Rattus norvegicus	186-217
9503561-4	1997	MAO-A preferentially deaminates serotonin (5HT) and is selectively inhibited by harmine and clorgyline, while MAO-B preferentially deaminates phenethylamine and benzylamine, and is selectively inhibited by (-)deprenyl as well as low concentrations of pargyline.	phenethylamine	142-156	monoamine oxidase A	Homo sapiens	0-5
9503561-4	1997	MAO-A preferentially deaminates serotonin (5HT) and is selectively inhibited by harmine and clorgyline, while MAO-B preferentially deaminates phenethylamine and benzylamine, and is selectively inhibited by (-)deprenyl as well as low concentrations of pargyline.	phenethylamine	142-156	monoamine oxidase B	Homo sapiens	110-115
9387886-2	1997	Aromatic L-amino acid decarboxylase (AADC) is rate limiting in the production of 2-phenylethylamine (2PE).	phenethylamine	81-99	dopa decarboxylase	Rattus norvegicus	0-35
9387886-2	1997	Aromatic L-amino acid decarboxylase (AADC) is rate limiting in the production of 2-phenylethylamine (2PE).	phenethylamine	81-99	dopa decarboxylase	Rattus norvegicus	37-41
9326944-2	1997	MAOA preferentially oxidizes serotonin (5-hydroxytryptamine, or 5-HT) and norepinephrine (NE), whereas MAOB preferentially oxidizes beta-phenylethylamine (PEA).	phenethylamine	132-153	monoamine oxidase B	Mus musculus	103-107
9326944-2	1997	MAOA preferentially oxidizes serotonin (5-hydroxytryptamine, or 5-HT) and norepinephrine (NE), whereas MAOB preferentially oxidizes beta-phenylethylamine (PEA).	phenethylamine	155-158	monoamine oxidase A	Mus musculus	0-4
9326944-2	1997	MAOA preferentially oxidizes serotonin (5-hydroxytryptamine, or 5-HT) and norepinephrine (NE), whereas MAOB preferentially oxidizes beta-phenylethylamine (PEA).	phenethylamine	155-158	monoamine oxidase B	Mus musculus	103-107
9301661-13	1997	These results are consistent with the proposed mechanism of action for phenethylamine hallucinogens, that such compounds must be full agonists at the 5-HT2A receptor subtype.	phenethylamine	71-85	5-hydroxytryptamine receptor 2A	Rattus norvegicus	150-156
9316835-1	1997	The biogenic amine phenethylamine has been shown to be N-oxygenated by human flavin-containing monooxygenase (FMO) (form 3) and human liver microsomes and, to a much lesser extent, N-oxygenated by porcine liver FMO1 and porcine liver microsomes but not by rabbit FMO2.	phenethylamine	19-33	dimethylaniline monooxygenase [N-oxide-forming] 2	Oryctolagus cuniculus	263-267
9258902-2	1997	MAO A and B activities were determined by measuring the rate of oxidation of the specific substrates phenethylamine and serotonin.	phenethylamine	101-115	monoamine oxidase A	Mus musculus	0-5
9106629-3	1997	Two findings indicate that MAO-B is the predominant isoform expressed in the renal proximal tubule cells: 1) Western blot performed with an anti-MAO-A/MAO-B polyclonal antiserum revealed a single 55-kDa band corresponding to MAO-B; 2) enzyme assays showed an elevated MAO-B activity ([14C]beta-phenylethylamine oxidation: Vmax = 1.31 +/- 0.41 nmol/min/mg protein), whereas MAO-A activity was only detectable ([14C]5-HT oxidation: Vmax = 80.3 +/- 19 pmol/min/mg protein).	phenethylamine	289-310	amine oxidase [flavin-containing] B	Oryctolagus cuniculus	27-32
9106629-3	1997	Two findings indicate that MAO-B is the predominant isoform expressed in the renal proximal tubule cells: 1) Western blot performed with an anti-MAO-A/MAO-B polyclonal antiserum revealed a single 55-kDa band corresponding to MAO-B; 2) enzyme assays showed an elevated MAO-B activity ([14C]beta-phenylethylamine oxidation: Vmax = 1.31 +/- 0.41 nmol/min/mg protein), whereas MAO-A activity was only detectable ([14C]5-HT oxidation: Vmax = 80.3 +/- 19 pmol/min/mg protein).	phenethylamine	289-310	amine oxidase [flavin-containing] B	Oryctolagus cuniculus	151-156
9106629-3	1997	Two findings indicate that MAO-B is the predominant isoform expressed in the renal proximal tubule cells: 1) Western blot performed with an anti-MAO-A/MAO-B polyclonal antiserum revealed a single 55-kDa band corresponding to MAO-B; 2) enzyme assays showed an elevated MAO-B activity ([14C]beta-phenylethylamine oxidation: Vmax = 1.31 +/- 0.41 nmol/min/mg protein), whereas MAO-A activity was only detectable ([14C]5-HT oxidation: Vmax = 80.3 +/- 19 pmol/min/mg protein).	phenethylamine	289-310	amine oxidase [flavin-containing] B	Oryctolagus cuniculus	151-156
9106629-3	1997	Two findings indicate that MAO-B is the predominant isoform expressed in the renal proximal tubule cells: 1) Western blot performed with an anti-MAO-A/MAO-B polyclonal antiserum revealed a single 55-kDa band corresponding to MAO-B; 2) enzyme assays showed an elevated MAO-B activity ([14C]beta-phenylethylamine oxidation: Vmax = 1.31 +/- 0.41 nmol/min/mg protein), whereas MAO-A activity was only detectable ([14C]5-HT oxidation: Vmax = 80.3 +/- 19 pmol/min/mg protein).	phenethylamine	289-310	amine oxidase [flavin-containing] B	Oryctolagus cuniculus	151-156
11671626-2	1997	In acetonitrile, the reaction of 3 (LH(2)) with phenethylamine and homoveratrylamine (molar ratio 1:2) affords solid dinuclear complexes [LH(2)]2RNH(2) (4a,b), which spectroscopic (FAB-MS, IR, (1)H and (13)C NMR) data point toward a strong participation of the pyrazole nitrogens in the amine complexation.	phenethylamine	48-62	FA complementation group B	Homo sapiens	181-184
8858937-12	1996	Possible mechanisms for the release-enhancing effect of the MAO-B inhibitors include elevation in levels of endogenous beta-phenylethylamine, or an inhibition of DA reuptake, which develops only on chronic administration, because both deprenyl and TVP-1012 have only very weak effects on amine uptake in acute experiments.	phenethylamine	119-140	monoamine oxidase B	Rattus norvegicus	60-65
8719417-5	1995	NS-49 is the phenethylamine class of alpha 1-adrenoceptor partial agonist relatively selective and efficacious for the human alpha 1a-adrenoceptor subtype, NS-49 would be potentially useful for studying the physiological role of alpha 1-adrenoceptor subtype.	phenethylamine	13-27	adrenoceptor alpha 1A	Homo sapiens	125-146
8819525-10	1996	Based on the present electrophysiological studies, we conclude that LSD and DOI, a phenethylamine hallucinogen, act as highly potent partial agonists at cortical 5-HT2A receptors.	phenethylamine	83-97	5-hydroxytryptamine receptor 2A	Rattus norvegicus	162-168
8789614-6	1995	Levels of 2-phenylethylamine (PE), a putative modulator of dopaminergic transmission, were increased by MAO-B inhibition in all three brain regions examined.	phenethylamine	10-28	monoamine oxidase B	Rattus norvegicus	104-109
8789614-6	1995	Levels of 2-phenylethylamine (PE), a putative modulator of dopaminergic transmission, were increased by MAO-B inhibition in all three brain regions examined.	phenethylamine	30-32	monoamine oxidase B	Rattus norvegicus	104-109
7721026-7	1994	MAO-B inhibitors can selectively and dramatically increase the level of beta-phenylethylamine, which has been shown to potentiate dopamine and noradrenaline function in the central nervous system.	phenethylamine	72-93	monoamine oxidase B	Homo sapiens	0-5
7651438-6	1995	AADC also plays a controlling role in the central nervous system, being a regulatory enzyme in the synthesis of a putative neuromodulator 2-phenylethylamine and other trace amines.	phenethylamine	138-156	dopa decarboxylase	Homo sapiens	0-4
8520468-2	1995	Enzyme activities were determined using as substrates p-phenetidine and procainamide for A-NAT, tryptamine and phenethylamine for AA-NAT.	phenethylamine	111-125	aralkylamine N-acetyltransferase	Gallus gallus	130-136
8847600-0	1995	SAR studies of fluorine-substituted benzylamines and substituted 2-phenylethylamines as substrates and inactivators of monoamine oxidase B.	phenethylamine	65-84	monoamine oxidase B	Homo sapiens	119-138
8138017-2	1993	Lipid peroxidation (LPO) in rat liver mitochondria decreased the activity of monoamine oxidase (MAO) with physiological substrates serotonin and 2-phenylethylamine (by 15-30%) and induced deamination of glucosamine, which was highly sensitive to selective MAO A inhibitor pirlindole.	phenethylamine	145-163	monoamine oxidase A	Rattus norvegicus	77-94
7945733-6	1994	A mixed type of inhibition by MDMA was observed for phenethylamine catabolism by MAO-B for both optical antipodes.	phenethylamine	52-66	monoamine oxidase B	Rattus norvegicus	81-86
7931255-2	1994	Although certain aromatic biogenic amines (e.g. tryptamine, tyramine, beta-phenyl-ethylamine) may be endogenous substrates for SSAO in species such as the rat, the weak activity of SSAO in human tissues towards these amines makes this less likely in man.	phenethylamine	70-92	amine oxidase, copper containing 3	Rattus norvegicus	127-131
7931269-3	1994	In contrast to the rat heart, beta-phenylethylamine is deaminated by MAO-B in the mouse heart.	phenethylamine	30-51	monoamine oxidase B	Rattus norvegicus	69-74
8138017-2	1993	Lipid peroxidation (LPO) in rat liver mitochondria decreased the activity of monoamine oxidase (MAO) with physiological substrates serotonin and 2-phenylethylamine (by 15-30%) and induced deamination of glucosamine, which was highly sensitive to selective MAO A inhibitor pirlindole.	phenethylamine	145-163	monoamine oxidase A	Rattus norvegicus	96-99
1729407-1	1992	Decarboxylation of phenylalanine by aromatic L-amino acid decarboxylase (AADC) is the rate-limiting step in the synthesis of 2-phenylethylamine (PE), a putative modulator of dopamine transmission.	phenethylamine	125-143	dopa decarboxylase	Rattus norvegicus	45-71
8245983-5	1993	The rank order for substrate inhibition of [3H]5-HT uptake for both the previously reported rat vMAT1 and the human transporter clone followed the order 5-HT > dopamine > epinephrine > norepinephrine > 1-methyl-4-phenylpyridinium > 2-phenylethylamine > histamine.	phenethylamine	247-265	solute carrier family 18 member A1	Rattus norvegicus	96-101
8242685-19	1993	The parallels between effects of increased 2-phenylethylamine availability and effects of administration of MAO inhibitor antidepressants on catecholamine receptor systems indicate that this substrate for MAO may mediate some of the effects of MAO inhibitor antidepressants.	phenethylamine	43-61	monoamine oxidase A	Rattus norvegicus	205-208
8242685-19	1993	The parallels between effects of increased 2-phenylethylamine availability and effects of administration of MAO inhibitor antidepressants on catecholamine receptor systems indicate that this substrate for MAO may mediate some of the effects of MAO inhibitor antidepressants.	phenethylamine	43-61	monoamine oxidase A	Rattus norvegicus	205-208
8371833-1	1993	Aromatic L-amino acid decarboxylase (AADC) is involved in the synthesis of the putative neurotransmitters dopamine (DA), 5-hydroxytryptamine (5-HT), and trace amines some of which have been proposed as neuromodulators, such as 2-phenylethylamine and tryptamine.	phenethylamine	227-245	dopa decarboxylase	Rattus norvegicus	0-35
8371833-1	1993	Aromatic L-amino acid decarboxylase (AADC) is involved in the synthesis of the putative neurotransmitters dopamine (DA), 5-hydroxytryptamine (5-HT), and trace amines some of which have been proposed as neuromodulators, such as 2-phenylethylamine and tryptamine.	phenethylamine	227-245	dopa decarboxylase	Rattus norvegicus	37-41
8333043-9	1993	In the transplanted liver, the activity of MAO with 5-HT and 2-phenylethylamine was increased by 26% (P < 0.05) and by 53% (P < 0.001), respectively.	phenethylamine	61-79	monoamine oxidase A	Rattus norvegicus	43-46
1729407-1	1992	Decarboxylation of phenylalanine by aromatic L-amino acid decarboxylase (AADC) is the rate-limiting step in the synthesis of 2-phenylethylamine (PE), a putative modulator of dopamine transmission.	phenethylamine	125-143	dopa decarboxylase	Rattus norvegicus	73-77
1729407-1	1992	Decarboxylation of phenylalanine by aromatic L-amino acid decarboxylase (AADC) is the rate-limiting step in the synthesis of 2-phenylethylamine (PE), a putative modulator of dopamine transmission.	phenethylamine	145-147	dopa decarboxylase	Rattus norvegicus	45-71
1729407-1	1992	Decarboxylation of phenylalanine by aromatic L-amino acid decarboxylase (AADC) is the rate-limiting step in the synthesis of 2-phenylethylamine (PE), a putative modulator of dopamine transmission.	phenethylamine	145-147	dopa decarboxylase	Rattus norvegicus	73-77
1601056-2	1992	Since monoamine oxidase (MAO) was not inhibited during the assay, the [3H]2-phenylethylamine binding may have been affected by an interaction between 2-phenylethylamine and the enzyme.	phenethylamine	74-92	monoamine oxidase A	Rattus norvegicus	6-23
1601056-2	1992	Since monoamine oxidase (MAO) was not inhibited during the assay, the [3H]2-phenylethylamine binding may have been affected by an interaction between 2-phenylethylamine and the enzyme.	phenethylamine	74-92	monoamine oxidase A	Rattus norvegicus	25-28
2251787-2	1990	It was shown that in experimental catatonia (as compared with rats of the corresponding control group) there was a dramatic increase in the brain stem of the rate of oxidative deamination of beta-phenylethylamine catalyzed by MAO-III; there was also a statistically significant (albeit less expressed than in the experiments with beta-phenylethylamine) increase in the rate of deamination of tyramine and a decrease in the rate of deamination of serotonin.	phenethylamine	191-212	monoamine oxidase A	Rattus norvegicus	226-229
1700071-7	1990	However, the relatively selective MAO-B substrate beta-phenylethylamine (PEA) was also oxidized, showing that these cultures also contained MAO-B activity; the Km values for MAO-A oxidation of 5-HT and MAO-B oxidation of PEA were 135 and 45 microM, and Vmax values were 88 and 91 nmol/mg of total cell protein/h, respectively.	phenethylamine	50-71	monoamine oxidase B	Rattus norvegicus	34-39
1700071-7	1990	However, the relatively selective MAO-B substrate beta-phenylethylamine (PEA) was also oxidized, showing that these cultures also contained MAO-B activity; the Km values for MAO-A oxidation of 5-HT and MAO-B oxidation of PEA were 135 and 45 microM, and Vmax values were 88 and 91 nmol/mg of total cell protein/h, respectively.	phenethylamine	50-71	monoamine oxidase B	Rattus norvegicus	140-145
1700071-7	1990	However, the relatively selective MAO-B substrate beta-phenylethylamine (PEA) was also oxidized, showing that these cultures also contained MAO-B activity; the Km values for MAO-A oxidation of 5-HT and MAO-B oxidation of PEA were 135 and 45 microM, and Vmax values were 88 and 91 nmol/mg of total cell protein/h, respectively.	phenethylamine	50-71	monoamine oxidase A	Rattus norvegicus	174-179
1700071-7	1990	However, the relatively selective MAO-B substrate beta-phenylethylamine (PEA) was also oxidized, showing that these cultures also contained MAO-B activity; the Km values for MAO-A oxidation of 5-HT and MAO-B oxidation of PEA were 135 and 45 microM, and Vmax values were 88 and 91 nmol/mg of total cell protein/h, respectively.	phenethylamine	50-71	monoamine oxidase B	Rattus norvegicus	140-145
1700071-7	1990	However, the relatively selective MAO-B substrate beta-phenylethylamine (PEA) was also oxidized, showing that these cultures also contained MAO-B activity; the Km values for MAO-A oxidation of 5-HT and MAO-B oxidation of PEA were 135 and 45 microM, and Vmax values were 88 and 91 nmol/mg of total cell protein/h, respectively.	phenethylamine	73-76	monoamine oxidase B	Rattus norvegicus	34-39
1700071-7	1990	However, the relatively selective MAO-B substrate beta-phenylethylamine (PEA) was also oxidized, showing that these cultures also contained MAO-B activity; the Km values for MAO-A oxidation of 5-HT and MAO-B oxidation of PEA were 135 and 45 microM, and Vmax values were 88 and 91 nmol/mg of total cell protein/h, respectively.	phenethylamine	73-76	monoamine oxidase B	Rattus norvegicus	140-145
1700071-7	1990	However, the relatively selective MAO-B substrate beta-phenylethylamine (PEA) was also oxidized, showing that these cultures also contained MAO-B activity; the Km values for MAO-A oxidation of 5-HT and MAO-B oxidation of PEA were 135 and 45 microM, and Vmax values were 88 and 91 nmol/mg of total cell protein/h, respectively.	phenethylamine	73-76	monoamine oxidase A	Rattus norvegicus	174-179
1700071-7	1990	However, the relatively selective MAO-B substrate beta-phenylethylamine (PEA) was also oxidized, showing that these cultures also contained MAO-B activity; the Km values for MAO-A oxidation of 5-HT and MAO-B oxidation of PEA were 135 and 45 microM, and Vmax values were 88 and 91 nmol/mg of total cell protein/h, respectively.	phenethylamine	73-76	monoamine oxidase B	Rattus norvegicus	140-145
1700071-8	1990	Higher concentrations of PEA (greater than 20 microM) were oxidized by both MAO-A and MAO-B isozymes.	phenethylamine	25-28	monoamine oxidase A	Rattus norvegicus	76-81
1700071-8	1990	Higher concentrations of PEA (greater than 20 microM) were oxidized by both MAO-A and MAO-B isozymes.	phenethylamine	25-28	monoamine oxidase B	Rattus norvegicus	86-91
1609114-5	1992	In the central nervous system of man MAO-A seems to be mainly involved in the metabolism of 5 HT and noradrenaline, whereas 2-phenylethylamine and probably dopamine are predominantly deaminated by MAO-B.	phenethylamine	124-142	monoamine oxidase B	Homo sapiens	197-202
1759390-6	1991	After selective inhibition of MAO-A by chlorgyline the order of MAO-B-dependent effects of biogenic amines on mitochondrial enzymes studied was as follows: tyramine greater than or equal to 2-phenylethylamine much greater than serotonin.	phenethylamine	190-208	monoamine oxidase B	Homo sapiens	64-69
1759390-7	1991	In deprenyl pretreated mitochondria the potency of MAO-A-dependent effects of these amines was: serotonin greater than tyramine much greater than much greater than 2-phenylethylamine.	phenethylamine	164-182	monoamine oxidase A	Homo sapiens	51-56
2251787-2	1990	It was shown that in experimental catatonia (as compared with rats of the corresponding control group) there was a dramatic increase in the brain stem of the rate of oxidative deamination of beta-phenylethylamine catalyzed by MAO-III; there was also a statistically significant (albeit less expressed than in the experiments with beta-phenylethylamine) increase in the rate of deamination of tyramine and a decrease in the rate of deamination of serotonin.	phenethylamine	330-351	monoamine oxidase A	Rattus norvegicus	226-229
2251787-3	1990	In the systems with MAO-II beta we detected statistically significant increase in the rates of deamination of tyramine and beta-phenylethylamine in experimental catatonia as compared with corresponding control.	phenethylamine	123-144	monoamine oxidase A	Rattus norvegicus	20-23
2123820-3	1990	In addition, apomorphine, a dopaminergic receptor agonist, and beta-phenylethylamine, a preferred substrate for MAO-B, were also used to garner corroborative evidence.	phenethylamine	63-84	monoamine oxidase B	Rattus norvegicus	112-117
34100120-2	2021	(khat), is a beta-keto analogue of amphetamine, sharing not only the phenethylamine structure, but also the amphetamine-like stimulant effects.	phenethylamine	69-83	amyloid beta precursor protein	Homo sapiens	11-17
20504622-4	1990	These values contrast with a K(i) of 800 ?M for rat liver mitochondrial MAO-A and an IC(50) of greater than 1 mM for the deamination of 2-phenylethylamine (mainly MAO-B).	phenethylamine	136-154	monoamine oxidase B	Rattus norvegicus	163-168
35233648-10	2022	CONCLUSION: Although hallucination-related HTR behavior induced by phenethylamine, ergoline, and tryptamine psychedelics appears to be 5-HT2AR-mediated, the receptor(s) responsible for behavioral disruptive effects may differ among these three structural classes.	phenethylamine	67-81	hesitator	Mus musculus	43-46
34301957-4	2021	In addition, WEC and phenethylamine decreased the methylglyoxal levels and increased the glyceraldehyde 3-phosphate dehydrogenase (GAPDH) protein levels in the liver.	phenethylamine	21-35	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	89-129
34301957-4	2021	In addition, WEC and phenethylamine decreased the methylglyoxal levels and increased the glyceraldehyde 3-phosphate dehydrogenase (GAPDH) protein levels in the liver.	phenethylamine	21-35	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	131-136
34301957-8	2021	Thus, trace amounts of phenethylamine alleviate HFD-induced liver damage by regulating methylglyoxal via increase of GAPDH.	phenethylamine	23-37	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	117-122
34996979-0	2022	Phenethylamine is a substrate of monoamine oxidase B in the paraventricular thalamic nucleus.	phenethylamine	0-14	monoamine oxidase B	Mus musculus	33-52
34996979-4	2022	To identify the MAO-B substrate in PVT, we generated Maob knockout (KO) mice and measured five candidate substrates (i.e., noradrenaline, dopamine, 3-methoxytyramine, serotonin, and phenethylamine (PEA)) by liquid chromatography tandem mass spectrometry.	phenethylamine	182-196	monoamine oxidase B	Mus musculus	16-21
34996979-4	2022	To identify the MAO-B substrate in PVT, we generated Maob knockout (KO) mice and measured five candidate substrates (i.e., noradrenaline, dopamine, 3-methoxytyramine, serotonin, and phenethylamine (PEA)) by liquid chromatography tandem mass spectrometry.	phenethylamine	198-201	monoamine oxidase B	Mus musculus	16-21