PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 23743286-4 2013 Substitutions with a hydroxy group at both R1 and R3 of the phenyl ring indicated that these groups play a major role in the high binding affinity to tyrosinase, especially through the hydrogen bonding interaction of the hydroxyl group at R1 with GLY281. Hydroxyl Radical 221-229 tyrosinase Mus musculus 150-160 23758537-2 2013 Synthesis of enantiomerically pure (S)-acetoxyglutarimide, stereoselective reductive intramolecular cyclization, hydroxyl group-assisted in situ N-Boc-deprotection, selective deoxygenation of the xanthate ester, and lactam hydrolysis followed by an appropriate exchange of nitrogen regioselectivity in intramolecular cyclization were the decisive steps. Hydroxyl Radical 113-121 BOC cell adhesion associated, oncogene regulated Homo sapiens 147-150 23357119-6 2013 We observed dose-dependent attenuation of the rotenone-induced loss in striatal dopamine, and nigral oxidized and reduced glutathione, as well as the increases in endogenous antioxidant enzymes (catalase and superoxide dismutase) activities supporting the notion that quercetin-effect is mediated via its powerful hydroxyl radicals-scavenging and antioxidant actions. Hydroxyl Radical 314-331 catalase Rattus norvegicus 195-228 23354476-0 2013 Theoretical study on rate constants for the reactions of CF3CH 2NH 2 (TFEA) with the hydroxyl radical at 298 K and atmospheric pressure. Hydroxyl Radical 85-101 transcription factor binding to IGHM enhancer 3 Homo sapiens 70-74 23674882-13 2013 Electron spin resonance revealed that Qing Dai possesses strong hydroxyl radical scavenging activity. Hydroxyl Radical 64-80 Z-DNA binding protein 1 Homo sapiens 43-46 23674882-15 2013 Scavenging of hydroxyl radicals appears to be a potential mechanism through which Qing Dai acts, but the significance of the scavenging ability of Qing Dai with respect to the anti-inflammatory effect in UC patients warrants further investigation. Hydroxyl Radical 14-31 Z-DNA binding protein 1 Homo sapiens 87-90 23485585-11 2013 The marked elevation of TrxR1 in many tumors could contribute to the selective tumor toxicity of these drugs by enhancing the redox activation of Fe(III)-thiosemicarbazones and the generation of reactive oxygen species such as HO. Hydroxyl Radical 227-229 thioredoxin reductase 1 Homo sapiens 24-29 23652787-4 2013 Since the structures in bulk solvent are much more compact than the crystallographic bound state, we formulate the hypothesis of a two-step docking mechanism: (i) formation of an intermediate between the compact, hydroxyl exposing conformations in solution and the catalytic zinc ion; (ii) structural rearrangement in the active site of TACE of the zinc-tethered drug in the final binding conformation. Hydroxyl Radical 213-221 ADAM metallopeptidase domain 17 Homo sapiens 337-341 23618537-8 2013 Multi-stage tandem mass spectrometry (MSn) experiments of SPE extracts of the ozonated samples of E1 and of a deuterium-labeled analogue (E1-d4) showed that OTP-276 and OTP-318 had carboxylic acid and hydroxyl functional groups, as previously reported for OTPs of other hormones. Hydroxyl Radical 201-209 orthopedia homeobox Homo sapiens 157-160 23618537-8 2013 Multi-stage tandem mass spectrometry (MSn) experiments of SPE extracts of the ozonated samples of E1 and of a deuterium-labeled analogue (E1-d4) showed that OTP-276 and OTP-318 had carboxylic acid and hydroxyl functional groups, as previously reported for OTPs of other hormones. Hydroxyl Radical 201-209 orthopedia homeobox Homo sapiens 169-172 23630074-0 2013 What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer. Hydroxyl Radical 20-28 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 43-46 23552906-3 2013 Among them, compounds containing 4-hydroxyl-substituted phenolic rings with C-2/C-4- or C-3/C-4-dihydroxyl-substituted diphenolic rings were more active (IC(50) = 1.74~16.74 muM) than 4-butylresorcinol and kojic acid, which suggested that the 4-hydroxyl groups in UCAs play a crucial role in tyrosinase inhibitory activities. Hydroxyl Radical 35-43 complement component 2 (within H-2S) Mus musculus 76-79 23552906-3 2013 Among them, compounds containing 4-hydroxyl-substituted phenolic rings with C-2/C-4- or C-3/C-4-dihydroxyl-substituted diphenolic rings were more active (IC(50) = 1.74~16.74 muM) than 4-butylresorcinol and kojic acid, which suggested that the 4-hydroxyl groups in UCAs play a crucial role in tyrosinase inhibitory activities. Hydroxyl Radical 35-43 tyrosinase Mus musculus 292-302 23382551-3 2013 AtHIRD11, which is the Arabidopsis KS-type dehydrin, inhibited generation of hydrogen peroxide and hydroxyl radicals in the Cu-ascorbate system. Hydroxyl Radical 99-116 dehydrin family protein Arabidopsis thaliana 0-8 23295203-6 2013 This strategy of predicting tyrosinase inhibition based on hydroxyl group numbers might be useful in the design and screening of potential tyrosinase inhibitors. Hydroxyl Radical 59-67 tyrosinase Homo sapiens 28-38 23295203-6 2013 This strategy of predicting tyrosinase inhibition based on hydroxyl group numbers might be useful in the design and screening of potential tyrosinase inhibitors. Hydroxyl Radical 59-67 tyrosinase Homo sapiens 139-149 23196068-3 2013 Synthesized dopamine can be neurotoxic through its enzymatic degradation by monoamine oxidase (MAO) to form the reactive byproduct, hydrogen peroxide and hydroxyl radicals or through auto-oxidation to form highly reactive quinones that can bind proteins and render them non-functional. Hydroxyl Radical 154-171 monoamine oxidase A Rattus norvegicus 76-93 23196068-3 2013 Synthesized dopamine can be neurotoxic through its enzymatic degradation by monoamine oxidase (MAO) to form the reactive byproduct, hydrogen peroxide and hydroxyl radicals or through auto-oxidation to form highly reactive quinones that can bind proteins and render them non-functional. Hydroxyl Radical 154-171 monoamine oxidase A Rattus norvegicus 95-98 23923420-7 2013 The uptake of Pb(II) by HMO was correlated with increasing surface hydroxyl group content and the main adsorbed speciation was PbOH+. Hydroxyl Radical 67-75 submaxillary gland androgen regulated protein 3B Homo sapiens 14-20 23274679-4 2013 The results indicated that LPC-1 had good scavenging ability on hydroxyl radicals. Hydroxyl Radical 64-81 annexin A1 Homo sapiens 27-32 23274679-3 2013 The antioxidant activity of LPC-1 was evaluated with the in vitro scavenging abilities on hydroxyl and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals. Hydroxyl Radical 90-98 annexin A1 Homo sapiens 28-33 23170793-4 2013 We have recently shown that trivalent iron (ferric ions) generates hydroxyl radicals, which subsequently convert FBG into abnormal fibrin clots in the form of DMDs. Hydroxyl Radical 67-84 fibrinogen beta chain Homo sapiens 113-116 23218546-3 2013 In this study, we investigated the mechanism of the initiation of root hair formation, mediated by the peroxidase-dependent production of the highly reactive hydroxyl radical in barley (Hordeum vulgare L.). Hydroxyl Radical 158-174 prx7 Hordeum vulgare 103-113 23218546-8 2013 Expression of two candidate peroxidase genes, HvPRX45 and HvPRX2, was analyzed and their possible role in root hair-specific production of hydroxyl radicals was discussed. Hydroxyl Radical 139-156 prx7 Hordeum vulgare 28-38 22819876-8 2013 The second-order rate constants for the hydroxyl radical-mediated PTP inactivation are at least 2-3 orders of magnitude higher than those mediated by H(2)O(2) under the same conditions. Hydroxyl Radical 40-56 protein tyrosine phosphatase receptor type U Homo sapiens 66-69 22819876-9 2013 Thus, hydroxyl radical generated in vivo may serve as a more physiologically relevant oxidizing agent for PTP inactivation. Hydroxyl Radical 6-22 protein tyrosine phosphatase receptor type U Homo sapiens 106-109 23077005-4 2013 The candidate surface-bound proteins are VEGF and anti-VEGF receptor (VEGF-R1 and VEGF-R2) antibodies, which were covalent-bound on poly(ethylene-co-vinyl alcohol) bearing a high-surface density of hydroxyl groups. Hydroxyl Radical 198-206 fms related receptor tyrosine kinase 1 Homo sapiens 70-77 23412873-7 2013 The analysis of Pq from MetHb-H2O2 peroxidase reaction mixture gave peaks at m/z 300.53 and m/z 243.42, corresponding to the hydroxyl and desamino derivative of Pq, respectively. Hydroxyl Radical 125-133 hemoglobin subunit gamma 2 Homo sapiens 24-29 23123341-9 2013 Through the measurements of H(2)O(2) and hydroxyl radicals (OH) in solutions containing different forms of Cu (II) (free and complexed by unstructured or alpha-helical alpha-syn), we demonstrate that the significantly enhanced Cu (I) binding affinity helps inhibit the production of highly toxic reactive oxygen species, especially the hydroxyl radicals. Hydroxyl Radical 336-353 synuclein alpha Homo sapiens 168-177 24348548-3 2013 Hydroxyl radicals were detected in the cytosolic fraction, and this was attributed to participation of xanthine oxidoreductase. Hydroxyl Radical 0-17 xanthine dehydrogenase Rattus norvegicus 103-126 23705505-4 2013 The regions near the rpS13e binding site in 18SCD (including the nucleotides of helices H20 and H22), whose availabilities to hydroxyl radicals were dependent on the Mg2+ concentration, were determined. Hydroxyl Radical 126-143 ribosomal protein S13 Homo sapiens 21-26 23460862-6 2013 Importantly, Cav-1 was shown to suppress hydrogen peroxide and hydroxyl radical formation by sustaining the level of activated Akt which was critical for the role of Cav-1 in attenuating the cell adhesion. Hydroxyl Radical 63-79 caveolin 1 Homo sapiens 13-18 23460862-6 2013 Importantly, Cav-1 was shown to suppress hydrogen peroxide and hydroxyl radical formation by sustaining the level of activated Akt which was critical for the role of Cav-1 in attenuating the cell adhesion. Hydroxyl Radical 63-79 AKT serine/threonine kinase 1 Homo sapiens 127-130 22953797-9 2012 It was suggested that SPD1 might contribute its antioxidant activities against hydroxyl and peroxyl radicals. Hydroxyl Radical 79-87 homeobox D13 Homo sapiens 22-26 23103029-0 2012 Evaluation of the ecotoxicity and biological efficacy of ship"s ballast water treatment based on hydroxyl radicals technique. Hydroxyl Radical 97-114 inositol polyphosphate-5-phosphatase D Homo sapiens 57-61 22763911-4 2012 The Al3 and Al1 active sites of the hydrated (110) and (100) surfaces are inactivated due to hydroxyl influence, respectively. Hydroxyl Radical 93-101 ephrin A5 Homo sapiens 12-15 23242019-2 2012 Pantoprazole as a proton pump inhibitor (PPI) has pancreatic anti-secretory effect and a pronounced inhibitory reactivity towards hydroxyl radicals. Hydroxyl Radical 130-147 ATPase H+/K+ transporting subunit alpha Homo sapiens 18-29 22725664-4 2012 EdAG scavenged hydroxyl radical generated in the Fenton reaction in a concentration-dependent manner was monitored by electron paramagnetic resonance (EPR) spectroscopy. Hydroxyl Radical 15-31 hemogen Homo sapiens 0-4 23079127-8 2012 It suggests that the degradation of MC-LR is initiated via the attack of hydroxyl radicals on the conjugated carbon double bonds of Adda and on the benzene ring of Adda. Hydroxyl Radical 73-90 adducin 1 Homo sapiens 132-136 22725664-6 2012 A captodatively stabilized carbon-centered radical intermediate was spin trapped in the reaction of EdAG with hydroxyl radical. Hydroxyl Radical 110-126 hemogen Homo sapiens 100-104 23079127-8 2012 It suggests that the degradation of MC-LR is initiated via the attack of hydroxyl radicals on the conjugated carbon double bonds of Adda and on the benzene ring of Adda. Hydroxyl Radical 73-90 adducin 1 Homo sapiens 164-168 22725664-8 2012 Observation of the hydroxyl trapping properties of EdAG suggests that the busulfan metabolite EdAG may contribute to or mitigate redox-related cytotoxicity associated with the therapeutic use of busulfan, and reaffirms indicators that support a role in free radical biology for dehydroalanine-containing peptides and proteins. Hydroxyl Radical 19-27 hemogen Homo sapiens 51-55 22725664-8 2012 Observation of the hydroxyl trapping properties of EdAG suggests that the busulfan metabolite EdAG may contribute to or mitigate redox-related cytotoxicity associated with the therapeutic use of busulfan, and reaffirms indicators that support a role in free radical biology for dehydroalanine-containing peptides and proteins. Hydroxyl Radical 19-27 hemogen Homo sapiens 94-98 23132938-2 2012 Here we combine cross-linking and hydroxyl radical probing to position the C82/34/31 subcomplex around the Pol III active center cleft. Hydroxyl Radical 34-50 complement C8 beta chain Homo sapiens 75-78 23039047-0 2012 Coaxially electrospun scaffolds based on hydroxyl-functionalized poly(epsilon-caprolactone) and loaded with VEGF for tissue engineering applications. Hydroxyl Radical 41-49 vascular endothelial growth factor A Homo sapiens 108-112 22927326-2 2012 A dual-path chemical mechanism, involving the overproduction of hydroxyl radicals and the formation of oxidizing cytochrome c intermediates, is responsible for the toxicity properties. Hydroxyl Radical 64-81 cytochrome c, somatic Homo sapiens 113-125 22402261-3 2012 In vitro activity analysis of the purified recombinant SBPase showed that SBPase was carbonylated by hydroxyl radicals, which led to enzyme inactivation in an H(2)O(2) dose-dependent manner. Hydroxyl Radical 101-118 sedoheptulose-bisphosphatase Arabidopsis thaliana 55-61 22771630-0 2012 Suppression of NF-kappaB signaling by andrographolide with a novel mechanism in human platelets: regulatory roles of the p38 MAPK-hydroxyl radical-ERK2 cascade. Hydroxyl Radical 130-146 mitogen-activated protein kinase 1 Homo sapiens 121-124 22771630-0 2012 Suppression of NF-kappaB signaling by andrographolide with a novel mechanism in human platelets: regulatory roles of the p38 MAPK-hydroxyl radical-ERK2 cascade. Hydroxyl Radical 130-146 mitogen-activated protein kinase 1 Homo sapiens 147-151 22402261-3 2012 In vitro activity analysis of the purified recombinant SBPase showed that SBPase was carbonylated by hydroxyl radicals, which led to enzyme inactivation in an H(2)O(2) dose-dependent manner. Hydroxyl Radical 101-118 sedoheptulose-bisphosphatase Arabidopsis thaliana 74-80 22901013-7 2012 Hydroxyl radical footprinting analysis of the HMGB4/platinated DNA complex reveals a footprinting pattern very different from that of HMGB1, however, revealing very little binding asymmetry with respect to the platinated lesion. Hydroxyl Radical 0-16 high mobility group box 4 Homo sapiens 46-51 22921065-3 2012 Here, we demonstrate that certain amino acid substitutions (in particular those containing hydroxyl or thiol groups) in the conserved GGQ glutamine of release factor RF1 can rescue defects in the release reaction associated with peptidyl-tRNA substrates lacking a 2" OH. Hydroxyl Radical 91-99 mitochondrial translation release factor 1 Homo sapiens 166-169 22356229-7 2012 TNF-alpha inhibitors also reduced the oxidative damage in MSC membrane and proteins, several antioxidant systems responded to treatments with a general inhibition of activities (glutathione S-transferase and catalase) and these effects were also supported by a general decrease of total oxyradical scavenging capacity towards hydroxyl radicals and peroxynitrite. Hydroxyl Radical 326-343 tumor necrosis factor Homo sapiens 0-9 22407500-10 2012 It seems that by decreasing the MAO-dependent DA metabolism rate, CSC raised cytosolic DA and by DA autoxidation, it induced hydroxyl radical overproduction. Hydroxyl Radical 125-141 monoamine oxidase A Rattus norvegicus 32-35 22382679-6 2012 Differences in the hydroxyl radical footprint were measured between Neupogen and the expired or mishandled GCSF samples, and confirmed by circular dichroism spectroscopy. Hydroxyl Radical 19-35 colony stimulating factor 3 Homo sapiens 108-112 22889519-0 2012 Hydroxyl radical-modified fibrinogen as a marker of thrombosis: the role of iron. Hydroxyl Radical 0-16 fibrinogen beta chain Homo sapiens 26-36 22889519-5 2012 Ferric chloride was also demonstrated to induce aggregation of purified fibrinogen at the same molar concentrations that were used for the generation of hydroxyl radicals. Hydroxyl Radical 154-171 fibrinogen beta chain Homo sapiens 72-82 22889519-7 2012 The mechanism of this phenomenon is very likely based on hydroxyl radical-induced modification of fibrinogen tertiary structure with the formation of insoluble aggregates resistant to enzymatic and chemical degradations. Hydroxyl Radical 58-74 fibrinogen beta chain Homo sapiens 99-109 22889519-10 2012 It is concluded that the detection of hydroxyl radical-modified fibrinogen may be utilized as a marker of a thrombotic condition in human subjects. Hydroxyl Radical 39-55 fibrinogen beta chain Homo sapiens 65-75 23252274-6 2012 RESULTS: The substrate was transformed to two new hydroxyl substituted triterpenoids, with a yield of 21.15%; The products displayed anti-proliferative effect against PC3 and DU145 cells with IC50 values of 14.5 micromol/L and 27.8 micromol/L, respectively. Hydroxyl Radical 50-58 chromobox 8 Homo sapiens 167-170 22579869-3 2012 And the antioxidant activities of PPS were investigated in vitro including reducing power, hydroxyl assay, superoxide radical assay and DPPH scavenge activity. Hydroxyl Radical 91-99 inositol polyphosphate-5-phosphatase K Homo sapiens 34-37 22356198-1 2012 The kinetics and abstraction rate coefficients of hydroxyl radical (OH) reaction with pinonaldehyde were computed using G3(MP2) theory and transition-state theory (TST) between 200 and 400 K. Structures of the reactants, reaction complexes (RCs), product complexes (PCs), transition states (TSs), and products were optimized at the MP2(FULL)/6-31G* level of theory. Hydroxyl Radical 50-66 thiosulfate sulfurtransferase Homo sapiens 164-167 22452294-3 2012 We investigate the oxidation of methacryloylperoxy nitrate (MPAN) and methacrylicperoxy acid (MPAA) by the hydroxyl radical (OH) theoretically, using both density functional theory [B3LYP] and explicitly correlated coupled cluster theory [CCSD(T)-F12]. Hydroxyl Radical 107-123 protein tyrosine phosphatase non-receptor type 22 Homo sapiens 184-187 22410721-7 2012 The degradation of MC-LR was initiated via three major pathways: attack of hydroxyl radicals on the conjugated carbon double bonds of Adda, attack of hydroxyl radicals on the benzene ring of Adda, and attack of nitrosonium ion on the benzene ring of Adda. Hydroxyl Radical 75-92 adducin 1 Homo sapiens 134-138 22397552-0 2012 Protection of ceruloplasmin by lactoferrin against hydroxyl radicals is pH dependent. Hydroxyl Radical 51-68 ceruloplasmin Homo sapiens 14-27 22397552-1 2012 Destruction of ceruloplasmin (Cp) in the presence of hydrogen peroxide is accompanied by the release of the protein"s copper ions that provoke formation of hydroxyl radicals (OH ) and, consequently, further degradation of the protein. Hydroxyl Radical 156-173 ceruloplasmin Homo sapiens 15-28 22499274-4 2012 Evaluation of deoxy UDP-Galf analogs revealed that the C-6 hydroxyl group is not essential for substrate activity, and that interactions with the UDP-Galf C-3 hydroxyl group orient the substrate for turnover but appears to play no role in substrate recognition, making the 3-deoxy-analog a moderate competitive inhibitor of the enzyme. Hydroxyl Radical 59-67 complement C6 Homo sapiens 55-58 22459924-3 2012 In vitro antioxidant assays showed that FUP-1 exhibited strong hydroxyl, superoxide anion and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging activities. Hydroxyl Radical 63-71 BTB (POZ) domain containing 7 Mus musculus 40-45 22475216-2 2012 In one series, C-3 hydroxyl derivatives were studied leading to a very active compound, when the C-3 hydroxyl group assumes 3beta stereochemistry (1, IC(50) = 0.18 muM). Hydroxyl Radical 19-27 latexin Homo sapiens 164-167 22564588-12 2012 The COX II inhibitor celecoxib significantly attenuated HPV responses (P < .05) and attenuated the elevated blood concentrations of TxB(2) (P < .05), hydroxyl radicals (P < .01), nitric oxide (P < .05), and COX II mRNA expression (P < .05) after H-R challenge. Hydroxyl Radical 156-173 cytochrome c oxidase II, mitochondrial Rattus norvegicus 4-10 22274589-4 2012 The analyses of Natural Bond Orbital and interaction energy using the B3LYP and MP2 (fc) methods suggested that the solubilization mechanism of microemulsion for naproxen mainly might be the formation of complex between the hydrogen atom of hydroxyl in Tween 80 and the oxygen atom of carbonyl group in naproxen, as is in accordance with the result from (1)H NMR experiments. Hydroxyl Radical 241-249 proline rich protein HaeIII subfamily 1 Mus musculus 80-83 22354161-6 2012 Investigation of the antioxidative properties showed that the polymeric Co(II) complex has a strong radical scavenging potency against hydroxyl radicals, 2,2-diphenyl-1-picrylhydrazyl radicals, nitric oxide and superoxide anion radicals. Hydroxyl Radical 135-152 mitochondrially encoded cytochrome c oxidase II Homo sapiens 72-78 22383521-8 2012 Subsequent experiments suggested that Vpu promotes BST-2 ubiquitination upon amino acid residues bearing hydroxyl- but not thiol-bearing side chains. Hydroxyl Radical 105-113 Vpu Human immunodeficiency virus 1 38-41 22383521-8 2012 Subsequent experiments suggested that Vpu promotes BST-2 ubiquitination upon amino acid residues bearing hydroxyl- but not thiol-bearing side chains. Hydroxyl Radical 105-113 bone marrow stromal cell antigen 2 Homo sapiens 51-56 22298789-3 2012 Based on X-ray crystal analysis of the ERRgamma ligand-binding domain (LBD)/BPA complex, we demonstrated that ERRgamma receptor residues, Glu275 and Arg316, function as the intrinsic-binding site of the phenol-hydroxyl group of BPA. Hydroxyl Radical 210-218 estrogen related receptor gamma Homo sapiens 110-118 22278974-3 2012 The free-hydroxyl groups on the surface of the HA/beta-TCP particles were sequentially conjugated with APTES, PEG-(SS)(2), and the synthetic MEPE peptide. Hydroxyl Radical 9-17 matrix extracellular phosphoglycoprotein Homo sapiens 141-145 22223306-1 2012 The effect of hydroxyl radical induced oxidation on the collision cross-sections of hen egg lysozyme and bovine ubiquitin was investigated by travelling wave ion mobility mass spectrometry for the first time. Hydroxyl Radical 14-30 ubiquitin Bos taurus 112-121 22298789-3 2012 Based on X-ray crystal analysis of the ERRgamma ligand-binding domain (LBD)/BPA complex, we demonstrated that ERRgamma receptor residues, Glu275 and Arg316, function as the intrinsic-binding site of the phenol-hydroxyl group of BPA. Hydroxyl Radical 210-218 estrogen related receptor gamma Homo sapiens 39-47 22443450-1 2012 BACKGROUND: Catalase is an important antioxidant enzyme that regulates the level of intracellular hydrogen peroxide and hydroxyl radicals. Hydroxyl Radical 120-137 catalase Mus musculus 12-20 22316432-6 2012 The results suggested that ion exchange between surface hydroxyl groups and As(V) or Cr(VI) species was accounted for by the adsorption. Hydroxyl Radical 56-64 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 76-81 22269608-10 2012 These findings suggest that cAMP signaling plays contradictory roles (stimulation and inhibition) in the production of hydroxyl radicals in rat striatum by differential actions of Epac and PKA. Hydroxyl Radical 119-136 Rap guanine nucleotide exchange factor 3 Rattus norvegicus 180-184 22269608-10 2012 These findings suggest that cAMP signaling plays contradictory roles (stimulation and inhibition) in the production of hydroxyl radicals in rat striatum by differential actions of Epac and PKA. Hydroxyl Radical 119-136 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 189-192 22269608-11 2012 These roles might contribute to the production of hydroxyl radicals concomitant with cAMP in carbon monoxide poisoning, because the formation of 2,3-DHBA was potentiated by the PKA inhibitor H89 and suppressed by Rp-8-Br-cAMPS, which inhibits PKA and Epac. Hydroxyl Radical 50-67 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 177-180 22269608-11 2012 These roles might contribute to the production of hydroxyl radicals concomitant with cAMP in carbon monoxide poisoning, because the formation of 2,3-DHBA was potentiated by the PKA inhibitor H89 and suppressed by Rp-8-Br-cAMPS, which inhibits PKA and Epac. Hydroxyl Radical 50-67 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 243-246 22269608-11 2012 These roles might contribute to the production of hydroxyl radicals concomitant with cAMP in carbon monoxide poisoning, because the formation of 2,3-DHBA was potentiated by the PKA inhibitor H89 and suppressed by Rp-8-Br-cAMPS, which inhibits PKA and Epac. Hydroxyl Radical 50-67 Rap guanine nucleotide exchange factor 3 Rattus norvegicus 251-255 22227335-13 2012 In summary, hydroxyl radical, hydrogen peroxide and superoxide anion-derived from endothelial NAD(P)H oxidase mediate the hyperreactivity to angiotensin II in type I-diabetic rat carotid, involving the participation of cyclooxygenase-1 and Rho-kinase. Hydroxyl Radical 12-28 angiotensinogen Rattus norvegicus 141-155 22227335-13 2012 In summary, hydroxyl radical, hydrogen peroxide and superoxide anion-derived from endothelial NAD(P)H oxidase mediate the hyperreactivity to angiotensin II in type I-diabetic rat carotid, involving the participation of cyclooxygenase-1 and Rho-kinase. Hydroxyl Radical 12-28 prostaglandin-endoperoxide synthase 1 Rattus norvegicus 219-235 22040722-10 2012 A direct transfer of ferric iron from ceruloplasmin to lactoferrin would prevent both the formation of potentially toxic hydroxyl radicals and the utilization of iron by pathogenic bacteria. Hydroxyl Radical 121-138 ceruloplasmin Homo sapiens 38-51 23097744-5 2012 According to HRGT, mammalian catalase apart from its known catalytic reaction generates hydroxyl radicals (HRs). Hydroxyl Radical 88-105 catalase Homo sapiens 29-37 22154834-1 2012 To develop a more potent NFkappaB inhibitor from salicylic acid which is known to inhibit activity of NFkappaB, a transcription factor regulating genes involved in immunity, inflammation and tumorigenesis, derivatives of salicylic acid (SA) where the 5 position, carboxyl or hydroxyl group was modified were treated in HCT116 cells transfected with an NFkappaB dependent luciferase gene and LPS-stimulated RAW264.7 cells. Hydroxyl Radical 275-283 nuclear factor kappa B subunit 1 Homo sapiens 25-33 22154834-1 2012 To develop a more potent NFkappaB inhibitor from salicylic acid which is known to inhibit activity of NFkappaB, a transcription factor regulating genes involved in immunity, inflammation and tumorigenesis, derivatives of salicylic acid (SA) where the 5 position, carboxyl or hydroxyl group was modified were treated in HCT116 cells transfected with an NFkappaB dependent luciferase gene and LPS-stimulated RAW264.7 cells. Hydroxyl Radical 275-283 nuclear factor kappa B subunit 1 Homo sapiens 102-110 22154834-1 2012 To develop a more potent NFkappaB inhibitor from salicylic acid which is known to inhibit activity of NFkappaB, a transcription factor regulating genes involved in immunity, inflammation and tumorigenesis, derivatives of salicylic acid (SA) where the 5 position, carboxyl or hydroxyl group was modified were treated in HCT116 cells transfected with an NFkappaB dependent luciferase gene and LPS-stimulated RAW264.7 cells. Hydroxyl Radical 275-283 nuclear factor kappa B subunit 1 Homo sapiens 102-110 22687421-4 2012 In the CYP51H10-introduced cells, beta-amyrin was converted to a metabolite with 12,13-epoxy and one additional hydroxyl group. Hydroxyl Radical 112-120 sterol 14-demethylase Saccharomyces cerevisiae S288C 7-12 23097744-0 2012 Hydroxyl radical generation theory: a possible explanation of unexplained actions of mammalian catalase. Hydroxyl Radical 0-16 catalase Homo sapiens 95-103 23097744-5 2012 According to HRGT, mammalian catalase apart from its known catalytic reaction generates hydroxyl radicals (HRs). Hydroxyl Radical 107-110 catalase Homo sapiens 29-37 22033917-0 2011 Structural analysis of proinsulin hexamer assembly by hydroxyl radical footprinting and computational modeling. Hydroxyl Radical 54-70 insulin Homo sapiens 23-33 22112169-8 2012 The data presented here suggest that Ft could be involved in the generation of free radicals, such as hydroxyl radical, by Fe-catalyzed reactions. Hydroxyl Radical 102-118 ferritin-1, chloroplastic Glycine max 37-39 22194171-3 2011 Human 8-oxoguanine glycosylase 1 (hOGG1) is an enzyme to repair specific DNA lesions and a good marker of hydroxyl radical damage to DNA. Hydroxyl Radical 108-116 8-oxoguanine DNA glycosylase Homo sapiens 35-40 22171396-4 2004 In addition, clinical symptoms of amyloidosis in a patient are influenced by the degree to which an organ is involved in the disease (3).The HSPG contain diverse types of oligosaccharides that are sulfated on the hydroxyl moieties to varying degrees, and these hypersulfated structures are distinct, are found specifically in the amyloid deposits, and differ from one another depending on the organ where they are located (4). Hydroxyl Radical 213-221 syndecan 2 Homo sapiens 141-145 22171393-4 2004 The HSPG contain diverse types of oligosaccharides that are sulfated on the hydroxyl moieties to varying degrees, and these hypersulfated structures are distinct, are found specifically in the amyloid deposits, and differ from one another depending on the organ where they are located (3). Hydroxyl Radical 76-84 syndecan 2 Homo sapiens 4-8 22007796-2 2011 The spin-trapping reaction rate constants of G-CYPMPO toward the hydroxyl radical and the hydrated electron were estimated to be (4.2 +- 0.1) x 10(9) and (11.8 +- 0.2) x 10(9) M(-1)s(-1), respectively. Hydroxyl Radical 65-81 spindlin 1 Homo sapiens 4-8 21913684-2 2011 4,6-Di-O-protected glucal and allal derivatives react with MCPBA to afford manno- and allo-1-O-m-chlorobenzoate derivatives, respectively, as a result of a syn epoxidation directed by the allylic hydroxyl group, and consecutive ring-opening by m-ClBzOH. Hydroxyl Radical 196-204 synemin Homo sapiens 156-159 21986200-0 2011 Myosin binding surface on actin probed by hydroxyl radical footprinting and site-directed labels. Hydroxyl Radical 42-58 myosin heavy chain 14 Homo sapiens 0-6 21683736-7 2011 Free radicals and hydroxyl radical levels increased by L-DOPA were decreased after combined treatment of L-DOPA and EPO. Hydroxyl Radical 18-34 erythropoietin Rattus norvegicus 105-119 21849609-6 2011 In contrast, H(2)O(2) suppressed neuronal activity in the CA1 region, and this effect was accentuated by coapplication of Fe(2+) and H(2)O(2), suggesting that hydroxyl radical generated by Fenton reaction mediates the effects of H(2)O(2) on CA1 neuronal activity. Hydroxyl Radical 159-175 carbonic anhydrase 1 Mus musculus 58-61 21849609-6 2011 In contrast, H(2)O(2) suppressed neuronal activity in the CA1 region, and this effect was accentuated by coapplication of Fe(2+) and H(2)O(2), suggesting that hydroxyl radical generated by Fenton reaction mediates the effects of H(2)O(2) on CA1 neuronal activity. Hydroxyl Radical 159-175 carbonic anhydrase 1 Mus musculus 241-244 21784110-8 2011 Taken together, the results strongly indicate that mitochondrial caspase-9 is not a downstream substrate of ER-specific caspase-12 and that pro-inflammatory cytokines cause apoptotic beta cell death through activation of caspase-9 primarily by hydroxyl radical-mediated mitochondrial damage. Hydroxyl Radical 244-260 caspase 9 Rattus norvegicus 221-230 21942783-2 2011 A chemical spin trap, 5,5-dimethyl-1-pyrroline-N-oxide (DMPO), in conjunction with electron paramagnetic resonance (EPR) spectroscopy was employed to measure the production of hydroxyl radical ( OH) in aqueous suspensions of 5% Cu(II)O/silica (3.9% Cu) particles containing environmentally persistent free radicals (EPFRs) of 2-monochlorophenol (2-MCP). Hydroxyl Radical 176-192 CD46 molecule Homo sapiens 348-351 21924559-9 2011 Since phosphates are much better leaving groups than hydroxyls, this destabilizes the C-2 amine bond and results in a spontaneous beta-elimination of the phosphate to regenerate an unmodified amine with the concomitant production of 4-deoxy-2,3-diulose. Hydroxyl Radical 53-62 complement component 2 (within H-2S) Mus musculus 86-89 21748189-7 2011 The data indicate permissive elaboration of hydroxyl at C-8 or C-9, enabling the possibility of improved pharmaceutical properties, whilst retaining potency against DNA-PK. Hydroxyl Radical 44-52 homeobox C8 Homo sapiens 56-59 21936877-5 2011 Stimulation of the AT(1) receptor with Ang II increased the formation of hydroxyl radicals in the striatum of intact rats as measured by the in vivo microdialysis salicylate trapping technique. Hydroxyl Radical 73-90 angiotensinogen Rattus norvegicus 39-45 21899930-7 2011 This study concludes that N,3-diphenylprop-2-enamide is a suitable scaffold for the design of selective MAO-B inhibitors and structural modifications to enhance the binding affinities of the inhibitors for the MAO-B active site include substitution with halogens on the N-phenyl ring and substitution with hydroxyl and nitrile functional groups on the para and meta positions, respectively, of the C3 phenyl ring. Hydroxyl Radical 306-314 monoamine oxidase B Homo sapiens 104-109 21899930-7 2011 This study concludes that N,3-diphenylprop-2-enamide is a suitable scaffold for the design of selective MAO-B inhibitors and structural modifications to enhance the binding affinities of the inhibitors for the MAO-B active site include substitution with halogens on the N-phenyl ring and substitution with hydroxyl and nitrile functional groups on the para and meta positions, respectively, of the C3 phenyl ring. Hydroxyl Radical 306-314 monoamine oxidase B Homo sapiens 210-215 21899930-8 2011 Possible binding modes of these structures within the MAO-B active site are proposed with the emphasis on the interactions of the inhibitor halogens and the hydroxyl and nitrile functional groups with active site residues and water molecules. Hydroxyl Radical 157-165 monoamine oxidase B Homo sapiens 54-59 21762045-3 2011 The variation in the production of oxidative species such as H(2)O(2), and subsequent hydroxyl radical generation, was measured during the course of QR2 activity under aerobic conditions and using pure human enzyme. Hydroxyl Radical 86-102 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 149-152 21762045-6 2011 The production of hydroxyl radicals is: (i) observed whatever the substrate/co-substrate used; ii) quenched by adding catalase; (iii) not observed with the specific QR2 inhibitor S29434; (iv) observed with the pro-drug CB1954. Hydroxyl Radical 18-35 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 165-168 21222511-2 2011 Structure-activity relationship study suggested that inhibitory activity against BACE1 was governed to a greater extent by the hydroxyl substituent on A- and B-ring of the chalcone, and the most active compound was substituted with four hydroxyl group (17, IC(50) = 0.27 muM). Hydroxyl Radical 127-135 beta-secretase 1 Homo sapiens 81-86 21222511-2 2011 Structure-activity relationship study suggested that inhibitory activity against BACE1 was governed to a greater extent by the hydroxyl substituent on A- and B-ring of the chalcone, and the most active compound was substituted with four hydroxyl group (17, IC(50) = 0.27 muM). Hydroxyl Radical 127-135 latexin Homo sapiens 271-274 21222511-2 2011 Structure-activity relationship study suggested that inhibitory activity against BACE1 was governed to a greater extent by the hydroxyl substituent on A- and B-ring of the chalcone, and the most active compound was substituted with four hydroxyl group (17, IC(50) = 0.27 muM). Hydroxyl Radical 237-245 beta-secretase 1 Homo sapiens 81-86 21222511-2 2011 Structure-activity relationship study suggested that inhibitory activity against BACE1 was governed to a greater extent by the hydroxyl substituent on A- and B-ring of the chalcone, and the most active compound was substituted with four hydroxyl group (17, IC(50) = 0.27 muM). Hydroxyl Radical 237-245 latexin Homo sapiens 271-274 21748189-7 2011 The data indicate permissive elaboration of hydroxyl at C-8 or C-9, enabling the possibility of improved pharmaceutical properties, whilst retaining potency against DNA-PK. Hydroxyl Radical 44-52 complement C9 Homo sapiens 63-66 21748189-7 2011 The data indicate permissive elaboration of hydroxyl at C-8 or C-9, enabling the possibility of improved pharmaceutical properties, whilst retaining potency against DNA-PK. Hydroxyl Radical 44-52 protein kinase, DNA-activated, catalytic subunit Homo sapiens 165-171 21740037-0 2011 Use of a coumarin-labeled hexa-arginine peptide as a fluorescent hydroxyl radical probe in a nanoparticulate plasmid DNA condensate. Hydroxyl Radical 65-81 hexosaminidase subunit alpha Homo sapiens 26-30 21573972-0 2011 Hydroxyl radical mediates cisplatin-induced apoptosis in human hair follicle dermal papilla cells and keratinocytes through Bcl-2-dependent mechanism. Hydroxyl Radical 0-16 BCL2 apoptosis regulator Homo sapiens 124-129 21697097-2 2011 Despite the ability of CYP24A1 to catabolize a wide range of 25-hydroxylated analogs including 25-hydroxyvitamin D(3), the enzyme is unable to metabolize the synthetic prodrug, 1alpha-hydroxyvitamin D(3) (1alpha-OH-D(3)), presumably because it lacks a C25-hydroxyl. Hydroxyl Radical 63-72 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 23-30 21827949-4 2011 In this study the solution structure of a CCL5 oligomer was investigated using an integrated approach, including NMR residual dipolar couplings to determine allowed relative orientations of the component monomers, SAXS to restrict overall shape, and hydroxyl radical footprinting and NMR cross-saturation experiments to identify interface residues. Hydroxyl Radical 250-266 C-C motif chemokine ligand 5 Homo sapiens 42-46 21573972-7 2011 The mechanism by which hydroxyl radical mediates the apoptotic effect of cisplatin was shown to involve down-regulation of the anti-apoptotic protein Bcl-2 through ubiquitin-proteasomal degradation. Hydroxyl Radical 23-39 BCL2 apoptosis regulator Homo sapiens 150-155 21573972-8 2011 Bcl-2 was also shown to have a negative regulatory role on hydroxyl radical. Hydroxyl Radical 59-75 BCL2 apoptosis regulator Homo sapiens 0-5 21573972-9 2011 Together, our results indicate an essential role of hydroxyl radical in cisplatin-induced cell death of hair follicle cells through Bcl-2 regulation. Hydroxyl Radical 52-68 BCL2 apoptosis regulator Homo sapiens 132-137 21761455-6 2011 The results demonstrated that the action of hypochlorite and chlorite involves the formation of superoxide and peroxide and that SOD1 is protective, probably by limiting the formation of hydroxyl radicals and damage to proteins. Hydroxyl Radical 187-204 superoxide dismutase SOD1 Saccharomyces cerevisiae S288C 129-133 21487676-6 2011 Expression of the H(2)O(2)-inactivating enzyme catalase in mitochondria protected against cytokine toxicity by preventing hydroxyl radical formation. Hydroxyl Radical 122-138 catalase Rattus norvegicus 47-55 21950100-4 2011 Also revealed is augmentation of lymphocyte caspase-3 functional activity 4 h after generation of singlet oxygen, hydroxyl radical and hydrogen peroxide addition, as well as 8 and 24 and 6 and 8 h after UV-irradiation of the cells at doses 151 and 1510 J/m2, correspondingly. Hydroxyl Radical 114-130 caspase 3 Homo sapiens 44-53 21359959-5 2011 It is concluded that apoplastic hydroxyl radical generation depends fully, or for the most part, on peroxidase localized in the cell wall. Hydroxyl Radical 32-48 peroxidase Glycine max 100-110 21711172-5 2011 The IC50 values of the ansu apricot oil for the superoxide anion radical system and the hydroxyl radical system were 0.15 mg mL-1 and 0.30 mg mL-1, respectively: stronger than that of the control (ascorbic acid). Hydroxyl Radical 88-104 L1 cell adhesion molecule Mus musculus 125-129 21711172-5 2011 The IC50 values of the ansu apricot oil for the superoxide anion radical system and the hydroxyl radical system were 0.15 mg mL-1 and 0.30 mg mL-1, respectively: stronger than that of the control (ascorbic acid). Hydroxyl Radical 88-104 L1 cell adhesion molecule Mus musculus 142-146 21359959-4 2011 By contrast, in membranes from other parts of the seedlings a low rate of spontaneous hydroxyl radical formation was observed due to the presence of small amounts of tightly bound peroxidase. Hydroxyl Radical 86-102 peroxidase Glycine max 180-190 21573299-1 2011 A theoretical study is presented of the mechanism and kinetics of the reactions of the hydroxyl radical with three ketones: dimethyl (DMK), ethylmethyl (EMK) and iso-propylmethyl (iPMK) ketones. Hydroxyl Radical 87-103 DM1 protein kinase Homo sapiens 134-137 21573299-1 2011 A theoretical study is presented of the mechanism and kinetics of the reactions of the hydroxyl radical with three ketones: dimethyl (DMK), ethylmethyl (EMK) and iso-propylmethyl (iPMK) ketones. Hydroxyl Radical 87-103 inositol polyphosphate multikinase Homo sapiens 180-184 21471000-9 2011 N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) postsynaptic receptor stimulation led to CBF-A accumulation in dendrites; increased Arc, BDNF, and CaMKIIalpha mRNA levels; and increased amounts of transcripts coprecipitating with CBF-A. Hydroxyl Radical 45-54 heterogeneous nuclear ribonucleoprotein A/B Mus musculus 135-140 21531760-6 2011 Hydroxyl radicals generated by the Fe(3+)/H(2)O(2) system were scavenged by both GmPM1 and GmPM9 in the absence or the presence of high ionic conditions (100 mM NaCl), although the scavenging activity of GmPM1 was significantly greater than that of GmPM9. Hydroxyl Radical 0-17 late embryogenesis abundant group 4 protein PM1 Glycine max 81-86 21531760-6 2011 Hydroxyl radicals generated by the Fe(3+)/H(2)O(2) system were scavenged by both GmPM1 and GmPM9 in the absence or the presence of high ionic conditions (100 mM NaCl), although the scavenging activity of GmPM1 was significantly greater than that of GmPM9. Hydroxyl Radical 0-17 late embryogenesis abundant group 4 protein PM1 Glycine max 204-209 21515281-5 2011 This work employs pulsed hydroxyl radical ( OH) labeling for tracking time-dependent accessibility changes during folding and assembly of the S100A11 homodimer. Hydroxyl Radical 25-41 S100 calcium binding protein A11 Homo sapiens 142-149 21471000-9 2011 N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) postsynaptic receptor stimulation led to CBF-A accumulation in dendrites; increased Arc, BDNF, and CaMKIIalpha mRNA levels; and increased amounts of transcripts coprecipitating with CBF-A. Hydroxyl Radical 45-54 activity regulated cytoskeletal-associated protein Mus musculus 178-181 21471000-9 2011 N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) postsynaptic receptor stimulation led to CBF-A accumulation in dendrites; increased Arc, BDNF, and CaMKIIalpha mRNA levels; and increased amounts of transcripts coprecipitating with CBF-A. Hydroxyl Radical 45-54 brain derived neurotrophic factor Mus musculus 183-187 21471000-9 2011 N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) postsynaptic receptor stimulation led to CBF-A accumulation in dendrites; increased Arc, BDNF, and CaMKIIalpha mRNA levels; and increased amounts of transcripts coprecipitating with CBF-A. Hydroxyl Radical 45-54 heterogeneous nuclear ribonucleoprotein A/B Mus musculus 276-281 21482471-4 2011 In the present study we have examined the inhibition of CYP1A1 and CYP1B1-catalyzed EROD activity by 14 different flavonoids containing methoxy- and hydroxyl-group substitutions as well as the metabolism of the monomethoxylated CYP1-flavonoid inhibitor acacetin and the poly-methoxylated flavone eupatorin-5-methyl ether by recombinant CYP1A1 and CYP1B1. Hydroxyl Radical 149-157 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 56-62 21462921-3 2011 The (6-4) PHR must catalyze not only covalent bond cleavage between two pyrmidine bases but also hydroxyl or amino group transfer from the 5"- to 3"-pyrimidine base, requiring a more complex mechanism than that postulated for CPD PHR. Hydroxyl Radical 97-105 MYC binding protein 2 Homo sapiens 10-13 21482471-4 2011 In the present study we have examined the inhibition of CYP1A1 and CYP1B1-catalyzed EROD activity by 14 different flavonoids containing methoxy- and hydroxyl-group substitutions as well as the metabolism of the monomethoxylated CYP1-flavonoid inhibitor acacetin and the poly-methoxylated flavone eupatorin-5-methyl ether by recombinant CYP1A1 and CYP1B1. Hydroxyl Radical 149-157 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 67-73 21482471-4 2011 In the present study we have examined the inhibition of CYP1A1 and CYP1B1-catalyzed EROD activity by 14 different flavonoids containing methoxy- and hydroxyl-group substitutions as well as the metabolism of the monomethoxylated CYP1-flavonoid inhibitor acacetin and the poly-methoxylated flavone eupatorin-5-methyl ether by recombinant CYP1A1 and CYP1B1. Hydroxyl Radical 149-157 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 56-60 21378183-9 2011 Spin-trapping experiments confirmed that Hpx(-) yaaA cells had a higher hydroxyl radical (HO( )) level. Hydroxyl Radical 72-88 hypothetical protein Escherichia coli 48-52 21284489-4 2011 Furthermore, its effect on generation of superoxide and hydroxyl radicals produced within infiltrated neutrophils was measured by cytochrome c and deoxyribose assay, respectively. Hydroxyl Radical 56-73 cytochrome c, somatic Homo sapiens 130-142 21281738-6 2011 Moreover, all compounds reduced hydroxyl radical generation by regulating the mRNA expression of alcohol dehydrogenase 1B and acetaldehyde dehydrogenase 2. Hydroxyl Radical 32-48 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 97-121 21281738-6 2011 Moreover, all compounds reduced hydroxyl radical generation by regulating the mRNA expression of alcohol dehydrogenase 1B and acetaldehyde dehydrogenase 2. Hydroxyl Radical 32-48 aldehyde dehydrogenase 2 family member Homo sapiens 126-154 21256985-6 2011 Hydroxyl radical footprinting showed that the binding site of S18e on the 18S rRNA is similar in general to the binding site of S13p on the 16S rRNA in the 30S ribosomal subunit, albeit the rRNA regions attributed to binding of the eukaryote-specific extensions of S18e were also detected. Hydroxyl Radical 0-16 ribosomal protein S13 Homo sapiens 128-132 20959117-1 2011 We have previously reported that pretreatment of human lymphoblastoid cells with the hydroxyl radical scavenger, N-acetyl cysteine, attenuates doxorubicin-induced DNA damage signalling through the ATM protein kinase. Hydroxyl Radical 85-101 ATM serine/threonine kinase Homo sapiens 197-200 21237148-0 2011 Central interleukin-10 attenuated lipopolysaccharide-induced changes in core temperature and hypothalamic glutamate, hydroxyl radicals and prostaglandin-E(2). Hydroxyl Radical 117-134 interleukin-10 Oryctolagus cuniculus 8-22 21237148-2 2011 This investigation was to determine whether central interleukin-10 (IL-10) exerted its antipyresis by reducing changes in circulating TNF-alpha and extracellular glutamate, hydroxyl radicals and PGE(2) in the hypothalamus. Hydroxyl Radical 173-190 interleukin-10 Oryctolagus cuniculus 52-66 21237148-2 2011 This investigation was to determine whether central interleukin-10 (IL-10) exerted its antipyresis by reducing changes in circulating TNF-alpha and extracellular glutamate, hydroxyl radicals and PGE(2) in the hypothalamus. Hydroxyl Radical 173-190 interleukin-10 Oryctolagus cuniculus 68-73 21714265-7 2011 TGA analysis showed that the heat resistance of modified wood increased, the three exothermic peaks in DTA curve of modified wood were 280, 360 and 485 degrees C which were higher than natural wood in the corresponding position FTIR analysis showed that the hydroxyl modified material has a good association phenomenon, and carbonyl content decreased. Hydroxyl Radical 258-266 T-box transcription factor 1 Homo sapiens 0-3 21237148-5 2011 Pretreatment with IL-10 (10-100ng, intracerebroventricularly) 1h before intravenous LPS significantly reduced the LPS-induced changes in extracellular glutamate, hydroxyl radicals, and PGE(2) in the hypothalamus and fever, but not the increased levels of TNF-alpha in rabbits. Hydroxyl Radical 162-179 interleukin-10 Oryctolagus cuniculus 18-23 21237148-6 2011 These findings suggested that directly injected IL-10 into the lateral cerebral ventricle 1h before intravenous LPS exerted its antipyresis by inhibiting the changes in extracellular glutamate, hydroxyl radicals and PGE(2) in the hypothalamus during LPS fever in rabbits. Hydroxyl Radical 194-211 interleukin-10 Oryctolagus cuniculus 48-53 20848217-5 2011 Antioxidation assays showed that the recombinant BbApoD protein had the capacities to scavenge hydroxyl radicals (>= 240 mug/ml) and to prevent nicking of the supercoiled DNA (>= 100 mug/ml) in vitro, providing a biochemical evidence for antioxidant role of ApoD. Hydroxyl Radical 95-112 apolipoprotein D Mus musculus 51-55 21904647-4 2011 In addition, hydroxyl radicals can reduce disulfide bonds in proteins, specifically fibrinogen, resulting in their unfolding and scrambled refolding into abnormal spatial configurations. Hydroxyl Radical 13-30 fibrinogen beta chain Homo sapiens 84-94 21152624-4 2011 [Co(II)-L(2)-Ln(III)] (18-25) series exhibit 2D open frameworks based on double-stranded helical motifs, which are further assembled into 3D porous structures by intermolecular hydrogen bonds between hydroxyl groups. Hydroxyl Radical 200-208 mitochondrially encoded cytochrome c oxidase II Homo sapiens 1-7 22254836-7 2011 A fibroblast growth factor-2 (FGF-2) neutralizing antibody and ROS scavengers for hydrogen peroxide and hydroxyl radicals abrogated these angiogenic effects. Hydroxyl Radical 104-121 fibroblast growth factor 2 Homo sapiens 2-28 22254836-7 2011 A fibroblast growth factor-2 (FGF-2) neutralizing antibody and ROS scavengers for hydrogen peroxide and hydroxyl radicals abrogated these angiogenic effects. Hydroxyl Radical 104-121 fibroblast growth factor 2 Homo sapiens 30-35 20942796-6 2011 Furthermore, HO-1 induction also was associated with slower rates of hydrogen peroxide and hydroxyl radical production by microsomes from rats induced for CYP1A2. Hydroxyl Radical 91-107 heme oxygenase 1 Rattus norvegicus 13-17 20942796-6 2011 Furthermore, HO-1 induction also was associated with slower rates of hydrogen peroxide and hydroxyl radical production by microsomes from rats induced for CYP1A2. Hydroxyl Radical 91-107 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 155-161 22174656-3 2011 SME also scavenged the hydroxyl radicals generated by the Fenton reaction (FeSO(4) + H(2)O(2)), which was detected using electron spin resonance spectrometry. Hydroxyl Radical 23-40 small nuclear ribonucleoprotein polypeptide E Homo sapiens 0-3 21105159-2 2011 Both PCL and PEG could be conveniently conjugated to the hydroxyl sites of chitosan without the need of tedious chemical protection/deprotection processes, thereby leaving the amino groups of chitosan intact. Hydroxyl Radical 57-65 progestagen associated endometrial protein Homo sapiens 13-16 20923773-6 2010 Superoxide anion and hydrogen peroxide down-regulated Cav-1 expression and inhibited cell migration and invasion, whereas hydroxyl radical up-regulated the Cav-1 expression and promoted cell migration and invasion. Hydroxyl Radical 122-138 caveolin 1 Homo sapiens 156-161 21799835-7 2011 Scavenging of hydroxyl radical by mannitol, inhibition of intrinsic lipoxygenase by catechol and removal of molecular oxygen considerably suppressed ultra-weak photon emission measured after the addition of linoleic acid. Hydroxyl Radical 14-30 uncharacterized protein Chlamydomonas reinhardtii 68-80 20085745-5 2010 Assessment of AOX activity in isolated Schizosaccharomyces pombe mitochondria revealed that mutation of either Gln242, Ser256, His261 and Arg262 resulted in >90% inhibition of antimycin A-insensitive respiration suggesting that hydroxyl, guanidino, imidazole groups, polar and charged residues in addition to the size of the amino-acid chain are important for ubiquinone-binding. Hydroxyl Radical 231-239 acyl-CoA oxidase 1 Homo sapiens 14-17 20633610-4 2010 In the hippocampus, the formation of hydroxyl radicals and the cerebral blood flow-independent formation of nitric oxide (NO) were strongly increased after reperfusion in SHRSP/Izm rats, and the neuronal expression of the thioredoxin and Bcl-2 genes was significantly decreased in the SHRSP/Izm rats compared with the WKY/Izm rats. Hydroxyl Radical 37-54 thioredoxin 1 Rattus norvegicus 222-233 20812376-5 2010 In this review, we describe a new application of hydroxyl radical protein footprinting to probe the time evolution of the calcium-dependent conformational changes of gelsolin on the millisecond timescale. Hydroxyl Radical 49-65 gelsolin Homo sapiens 166-174 21127001-1 2010 Neuronal activity regulated pentraxin (Narp) is a secreted protein that regulates alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors (AMPAR) aggregation and synaptogenesis. Hydroxyl Radical 96-104 neuronal pentraxin 2 Mus musculus 0-37 21127001-1 2010 Neuronal activity regulated pentraxin (Narp) is a secreted protein that regulates alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors (AMPAR) aggregation and synaptogenesis. Hydroxyl Radical 96-104 neuronal pentraxin 2 Mus musculus 39-43 20603196-4 2010 In the case of the ganoderma alcohols with the same number of hydroxyl groups in 17beta-side chain, the one which has C-3 carbonyl group showed better binding activity to androgen receptor than that which has C-3 hydroxyl group. Hydroxyl Radical 62-70 androgen receptor Homo sapiens 171-188 20859255-1 2010 Tethered hydroxyl-radical probing has been used to determine the orientation of binding of polypyrimidine tract-binding protein (PTB) to the poliovirus type 1 (Mahoney) (PV-1(M)) internal ribosome entry site/segment (IRES)-the question of which RNA-binding domain (RBD) binds to which sites on the IRES. Hydroxyl Radical 9-25 polypyrimidine tract binding protein 1 Homo sapiens 129-132 20825246-7 2010 Hydroxyl radical-mediated protein footprinting coupled with mass spectrometry analysis was employed to provide detailed information about protein structure of gp120-OD8 by directly identifying accessible and hydroxyl radical-reactive side chain residues. Hydroxyl Radical 0-16 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 159-164 20825246-7 2010 Hydroxyl radical-mediated protein footprinting coupled with mass spectrometry analysis was employed to provide detailed information about protein structure of gp120-OD8 by directly identifying accessible and hydroxyl radical-reactive side chain residues. Hydroxyl Radical 208-224 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 159-164 20633610-4 2010 In the hippocampus, the formation of hydroxyl radicals and the cerebral blood flow-independent formation of nitric oxide (NO) were strongly increased after reperfusion in SHRSP/Izm rats, and the neuronal expression of the thioredoxin and Bcl-2 genes was significantly decreased in the SHRSP/Izm rats compared with the WKY/Izm rats. Hydroxyl Radical 37-54 BCL2, apoptosis regulator Rattus norvegicus 238-243 20681542-2 2010 The gas phase reaction between nitric acid and hydroxyl radical, without and with a single water molecule, has been investigated theoretically using the DFT-B3LYP, MP2, QCISD, and CCSD(T) theoretical approaches with the 6-311+G(2df,2p) and aug-cc-pVTZ basis sets. Hydroxyl Radical 47-63 tryptase pseudogene 1 Homo sapiens 164-167 20457604-5 2010 The peroxidase activity of wild-type TrxR efficiently converted the O adduct (DEPMPO/HOO(*)) to the hydroxyl radical adduct (DEPMPO/HO(*)). Hydroxyl Radical 100-116 peroxiredoxin 5 Homo sapiens 37-41 20600839-0 2010 Inhibition of vascular smooth muscle cell proliferation by the vitamin E derivative pentamethylhydroxychromane in an in vitro and in vivo study: pivotal role of hydroxyl radical-mediated PLCgamma1 and JAK2 phosphorylation. Hydroxyl Radical 161-177 phospholipase C, gamma 1 Rattus norvegicus 187-196 20600839-0 2010 Inhibition of vascular smooth muscle cell proliferation by the vitamin E derivative pentamethylhydroxychromane in an in vitro and in vivo study: pivotal role of hydroxyl radical-mediated PLCgamma1 and JAK2 phosphorylation. Hydroxyl Radical 161-177 Janus kinase 2 Rattus norvegicus 201-205 20600839-11 2010 The inhibitory mechanism of PMC may involved the inhibition of hydroxyl radical-mediated PLCgamma1-PKCdelta and JAK2-STAT3 activation and causes cell cycle arrest at the G(2)/M phase. Hydroxyl Radical 63-79 phospholipase C, gamma 1 Rattus norvegicus 89-98 20600839-11 2010 The inhibitory mechanism of PMC may involved the inhibition of hydroxyl radical-mediated PLCgamma1-PKCdelta and JAK2-STAT3 activation and causes cell cycle arrest at the G(2)/M phase. Hydroxyl Radical 63-79 Janus kinase 2 Rattus norvegicus 112-116 20600839-11 2010 The inhibitory mechanism of PMC may involved the inhibition of hydroxyl radical-mediated PLCgamma1-PKCdelta and JAK2-STAT3 activation and causes cell cycle arrest at the G(2)/M phase. Hydroxyl Radical 63-79 signal transducer and activator of transcription 3 Rattus norvegicus 117-122 20586543-5 2010 RESULTS: Both hydroxyl and azide radicals induce centrin 2 polymerisation as we characterised several intermolecular cross-links generating dimers, trimers, tetramers and higher molecular mass species. Hydroxyl Radical 14-22 centrin 2 Homo sapiens 49-58 20537368-5 2010 EpsilondG and pdG-HNE behave differently upon hydroxyl radical and one electron oxidation reactions. Hydroxyl Radical 46-62 phosphoglycerate dehydrogenase Homo sapiens 14-17 20815772-1 2010 The present study investigated the effects of oxidative stress induced by reactive oxygen species (ROS), such as hydrogen peroxide (H(2)O(2)) and hydroxyl radical (HO(*)), on the expression of both BRAK , which is also known as non-ELR motif angiostatic CXC chemokine ligand 14 (CXCL14), in head and neck squamous cell carcinoma (HNSCC) cells. Hydroxyl Radical 146-162 C-X-C motif chemokine ligand 14 Homo sapiens 198-202 21261038-1 2010 Novel hydroxyl-terminated ionic liquids of 1-(6-hydroxyhexyl)-3-butyl imidazolium bis(trifluoromethyl) sulfonylimide (HHBIM-NTf2) and 1-(8-hydroxyoctyl) -3-butyl imidazolium bis(trifluoromethyl) sulfonylimide (HOBIM-NTf2) were synthesized as stationary phases for capillary gas chromatography (GC). Hydroxyl Radical 6-14 nuclear transport factor 2 Homo sapiens 124-128 21261038-1 2010 Novel hydroxyl-terminated ionic liquids of 1-(6-hydroxyhexyl)-3-butyl imidazolium bis(trifluoromethyl) sulfonylimide (HHBIM-NTf2) and 1-(8-hydroxyoctyl) -3-butyl imidazolium bis(trifluoromethyl) sulfonylimide (HOBIM-NTf2) were synthesized as stationary phases for capillary gas chromatography (GC). Hydroxyl Radical 6-14 nuclear transport factor 2 Homo sapiens 216-220 19618264-8 2010 Extracellular H(2)O(2) and intracellular hydroxyl radical were found to play critical roles in the cytotoxicity of ACMS-GOX. Hydroxyl Radical 41-57 hydroxyacid oxidase 1, liver Mus musculus 120-123 20435140-2 2010 Introduction of the 1alpha-hydroxyl group into 25-hydroxyvitamin D3 (2) to produce 1alpha,25-dihydroxyvitamin D3 (1) increases the VDR binding affinity by approximately 1000-fold. Hydroxyl Radical 27-35 vitamin D receptor Homo sapiens 131-134 20045244-6 2010 The proposed mechanism is based on the shifting of flat band potential of SnO(2) due to the interaction with Mg/Al-LDH, this being energetically favourable to the formation of hydroxyl radicals responsible for methylene blue degradation. Hydroxyl Radical 176-193 strawberry notch homolog 2 Homo sapiens 74-77 20398641-2 2010 Results showed that the peroxidation of PLPC is decreased in the presence of Cyt c, meaning that this latter is the preferential target of hydroxyl radicals. Hydroxyl Radical 139-156 cytochrome c, somatic Homo sapiens 77-82 20307504-11 2010 Hydroxyl radical scavenger significantly reduced phosphorylation of STAT1. Hydroxyl Radical 0-16 signal transducer and activator of transcription 1 Rattus norvegicus 68-73 20202668-6 2010 First, the conjugated diene structure of Adda moiety was attacked by hydroxyl radical (OH()) to produce dihydroxylated products, then the hydroxylated 4-5 and/or 6-7 bond of Adda was cleaved into aldehyde or ketone peptide residues, and finally the residues were oxidized into the corresponding carboxylic acids. Hydroxyl Radical 69-85 adducin 1 Homo sapiens 41-45 20459757-11 2010 Agents that generate hydroxyl and superoxide radicals reduce EBNA1"s activity but increase transactivation by Tat. Hydroxyl Radical 21-29 EBNA-1 Human gammaherpesvirus 4 61-66 20442931-3 2010 Considering that hydroxyl radical (*OH) is the dominant factor that causes the degradation of p-NP, the enhanced degradation that occurred in the presence of the extra light source was attributed to the synergistic effect between *OH attack and the primary reactions initiated by 254 nm UV light. Hydroxyl Radical 17-33 purine nucleoside phosphorylase Homo sapiens 94-98 20225809-0 2010 Rate coefficients for the gas-phase reaction of the hydroxyl radical with CH2=CHF and CH2=CF2. Hydroxyl Radical 52-68 ATPase H+ transporting accessory protein 1 Homo sapiens 90-93 20185830-7 2010 The ion transporter SLC4A11 mediates sodium-dependent transport of borate as well as flux of sodium and hydroxyl ions in vitro. Hydroxyl Radical 104-112 solute carrier family 4 member 11 Homo sapiens 20-27 20376873-2 2010 Electrostatically bound Cyt-c on pure carboxyl-terminated and mixed carboxyl/hydroxyl-terminated SAMs reveals the same distance dependence of the rate constants, that is, electron tunneling at long distances and a regime controlled by the protein orientational distribution and dynamics that leads to a nearly distance-independent rate constant at short distances. Hydroxyl Radical 77-85 cytochrome c, somatic Homo sapiens 24-29 20202668-6 2010 First, the conjugated diene structure of Adda moiety was attacked by hydroxyl radical (OH()) to produce dihydroxylated products, then the hydroxylated 4-5 and/or 6-7 bond of Adda was cleaved into aldehyde or ketone peptide residues, and finally the residues were oxidized into the corresponding carboxylic acids. Hydroxyl Radical 69-85 adducin 1 Homo sapiens 174-178 19839568-2 2010 We demonstrate that PCC, a mild oxidant, can be used to convert hydroxyl-terminated SAMs to aldehydes and decorated with a variety of oxyamine-containing molecules. Hydroxyl Radical 64-72 crystallin gamma D Homo sapiens 20-23 19839568-2 2010 We demonstrate that PCC, a mild oxidant, can be used to convert hydroxyl-terminated SAMs to aldehydes and decorated with a variety of oxyamine-containing molecules. Hydroxyl Radical 64-72 methionine adenosyltransferase 1A Homo sapiens 84-88 19958757-0 2010 Interleukin-1 receptor antagonist inhibits the release of glutamate, hydroxyl radicals, and prostaglandin E(2) in the hypothalamus during pyrogen-induced fever in rabbits. Hydroxyl Radical 69-86 interleukin-1 receptor antagonist intracellular form Oryctolagus cuniculus 0-33 19958757-1 2010 The present study was attempted to determine whether interleukin-1 receptor antagonist (IL-1ra) pretreatment exerts its antipyresis by reducing organum vasculosum laminae terminalis (OVLT) release of glutamate, hydroxyl radicals and prostaglandin E(2) in rabbits. Hydroxyl Radical 211-228 interleukin-1 receptor antagonist intracellular form Oryctolagus cuniculus 53-86 19958757-1 2010 The present study was attempted to determine whether interleukin-1 receptor antagonist (IL-1ra) pretreatment exerts its antipyresis by reducing organum vasculosum laminae terminalis (OVLT) release of glutamate, hydroxyl radicals and prostaglandin E(2) in rabbits. Hydroxyl Radical 211-228 interleukin-1 receptor antagonist intracellular form Oryctolagus cuniculus 88-94 19958757-3 2010 The rise in both the core temperature and OVLT glutamate, hydroxyl radicals and prostaglandin E(2) could also be induced by intracerebroventricular injection of interleukin-1beta. Hydroxyl Radical 58-75 interleukin-1 beta Oryctolagus cuniculus 161-178 19958757-4 2010 Pretreatment with an intracerebroventricular dose of IL-1ra significantly prevented the lipopolysaccharide or IL-1beta-induced overproduction of glutamate, hydroxyl radicals, and prostaglandin E(2) in OVLT of rabbit"s brain. Hydroxyl Radical 156-173 interleukin-1 receptor antagonist intracellular form Oryctolagus cuniculus 53-59 19958757-4 2010 Pretreatment with an intracerebroventricular dose of IL-1ra significantly prevented the lipopolysaccharide or IL-1beta-induced overproduction of glutamate, hydroxyl radicals, and prostaglandin E(2) in OVLT of rabbit"s brain. Hydroxyl Radical 156-173 interleukin-1 beta Oryctolagus cuniculus 110-118 20058916-1 2010 The air-water interface in atmospheric water films of aerosols and hydrometeors (fog, mist, ice, rain, and snow) presents an important surface for the adsorption and reaction of many organic trace gases and gaseous reactive oxidants (hydroxyl radical (OH(. Hydroxyl Radical 234-250 zinc finger protein, FOG family member 1 Homo sapiens 81-84 20131850-2 2010 Hydroxyl radical substitution into oxalyl dichloride [ClC(O)C(O)Cl] and oxalyl dibromide [BrC(O)C(O)Br], resulting in the formation of oxalic acid, is presented. Hydroxyl Radical 0-16 Charcot-Leyden crystal galectin Homo sapiens 54-57 20117080-0 2010 The EGCg-induced redox-sensitive activation of endothelial nitric oxide synthase and relaxation are critically dependent on hydroxyl moieties. Hydroxyl Radical 124-132 nitric oxide synthase 3 Homo sapiens 47-80 20039725-13 2010 Among the three complexes, the dppz complex 3 shows significant BSA and lysozyme protein cleavage activity in UV-A light of 365 nm via hydroxyl radical pathway. Hydroxyl Radical 135-151 lysozyme Homo sapiens 72-80 21061463-9 2010 Moreover, the activities of CAT, SOD, GPx and anti-hydroxyl radicals in mice liver were increased significantly by CMP. Hydroxyl Radical 51-68 matrilin 1, cartilage matrix protein Mus musculus 115-118 19731237-2 2009 Manganese superoxide dismutase (MnSOD) converts superoxide anion into hydrogen peroxide, which, unless detoxified by glutathione peroxidase or catalase (CAT), can form the hydroxyl radical with iron. Hydroxyl Radical 172-188 superoxide dismutase 2 Homo sapiens 0-30 19830768-1 2009 The effect of a single water molecule on the reaction mechanism of the gas-phase reaction between formic acid and the hydroxyl radical was investigated with high-level quantum mechanical calculations using DFT-B3LYP, MP2 and CCSD(T) theoretical approaches in concert with the 6-311+G(2df,2p) and aug-cc-pVTZ basis sets. Hydroxyl Radical 118-134 tryptase pseudogene 1 Homo sapiens 217-220 19560504-5 2009 Since H(2)O(2) is the main source of the highly reactive hydroxyl radical in the brain, and FeCl(2) can stimulate oxidative stress, including the formation of the hydroxyl radical from H(2)O(2), in the present work we studied the effect of these two pro-oxidant molecules on the levels and processing of human APP by alpha-, beta- and gamma-secretase, and the role of the stress-activated kinase c-jun N-terminal kinase (JNK). Hydroxyl Radical 163-179 mitogen-activated protein kinase 8 Homo sapiens 396-419 19560504-5 2009 Since H(2)O(2) is the main source of the highly reactive hydroxyl radical in the brain, and FeCl(2) can stimulate oxidative stress, including the formation of the hydroxyl radical from H(2)O(2), in the present work we studied the effect of these two pro-oxidant molecules on the levels and processing of human APP by alpha-, beta- and gamma-secretase, and the role of the stress-activated kinase c-jun N-terminal kinase (JNK). Hydroxyl Radical 163-179 mitogen-activated protein kinase 8 Homo sapiens 421-424 19709810-4 2009 The obtained results show that the driving force of Pb(II) adsorption on titania coatings is electrostatic interaction, and that Pb(II) is adsorbed onto titania coatings by Pb(II) ions coordinating with hydroxyl groups of titania surface. Hydroxyl Radical 203-211 submaxillary gland androgen regulated protein 3B Homo sapiens 52-58 19709810-4 2009 The obtained results show that the driving force of Pb(II) adsorption on titania coatings is electrostatic interaction, and that Pb(II) is adsorbed onto titania coatings by Pb(II) ions coordinating with hydroxyl groups of titania surface. Hydroxyl Radical 203-211 submaxillary gland androgen regulated protein 3B Homo sapiens 129-135 19709810-4 2009 The obtained results show that the driving force of Pb(II) adsorption on titania coatings is electrostatic interaction, and that Pb(II) is adsorbed onto titania coatings by Pb(II) ions coordinating with hydroxyl groups of titania surface. Hydroxyl Radical 203-211 submaxillary gland androgen regulated protein 3B Homo sapiens 129-135 19731237-2 2009 Manganese superoxide dismutase (MnSOD) converts superoxide anion into hydrogen peroxide, which, unless detoxified by glutathione peroxidase or catalase (CAT), can form the hydroxyl radical with iron. Hydroxyl Radical 172-188 superoxide dismutase 2 Homo sapiens 32-37 19731237-2 2009 Manganese superoxide dismutase (MnSOD) converts superoxide anion into hydrogen peroxide, which, unless detoxified by glutathione peroxidase or catalase (CAT), can form the hydroxyl radical with iron. Hydroxyl Radical 172-188 catalase Homo sapiens 153-156 19508642-4 2009 The hydroxyl-bearing axial ligands tend to reduce aggregation of the Pc and direct it to lysosomes, resulting in four to six times more killing of cells, as defined by loss of clonogenicity, than with Pc 4. Hydroxyl Radical 4-12 proprotein convertase subtilisin/kexin type 4 Homo sapiens 201-205 19533309-3 2009 Upon addition of Catalase (Ct), the system produced hydroxyl radical that oxidized the Au@Ag nanoprobe to form the AuAg nanoparticles with partly bare nanogold. Hydroxyl Radical 52-68 catalase Homo sapiens 17-25 19533309-3 2009 Upon addition of Catalase (Ct), the system produced hydroxyl radical that oxidized the Au@Ag nanoprobe to form the AuAg nanoparticles with partly bare nanogold. Hydroxyl Radical 52-68 catalase Homo sapiens 27-29 19789182-6 2009 Substitutions that removed a single hydroxyl moiety either decreased (Y19F, Y34, Y161F) or increased (Y4F) emerin binding to BAF in cells. Hydroxyl Radical 36-44 emerin Homo sapiens 107-113 19789182-6 2009 Substitutions that removed a single hydroxyl moiety either decreased (Y19F, Y34, Y161F) or increased (Y4F) emerin binding to BAF in cells. Hydroxyl Radical 36-44 BAF nuclear assembly factor 1 Homo sapiens 125-128 19629454-4 2009 ILs containing [FAP]- possessed lower hydrogen bond basicity than NTf2-based ILs having the same cationic component; in the case of hydroxyl-functionalized cations, the presence of [FAP]- led to an enhancement of the hydrogen bond acidity, relative to the NTf2-analogs. Hydroxyl Radical 132-140 nuclear transport factor 2 Homo sapiens 66-70 19629454-4 2009 ILs containing [FAP]- possessed lower hydrogen bond basicity than NTf2-based ILs having the same cationic component; in the case of hydroxyl-functionalized cations, the presence of [FAP]- led to an enhancement of the hydrogen bond acidity, relative to the NTf2-analogs. Hydroxyl Radical 132-140 nuclear transport factor 2 Homo sapiens 256-260 19665044-9 2009 GAA stimulate hydroxyl radicals (()OH) generation and DNA damage. Hydroxyl Radical 14-31 alpha glucosidase Rattus norvegicus 0-3 19693771-8 2009 Hb-induced IDO expression was inhibited by anti-oxidant N-acetyl-L-cysteine (NAC) or mixtures of SOD and catalase, however, IDO expression was enhanced by 3-amino-1,2,4-triazole, an inhibitor of catalase, suggesting that the generation of ROS such as O(2) (-), H(2)O(2), and hydroxyl radical is required for the induction of IDO expression. Hydroxyl Radical 275-291 indoleamine 2,3-dioxygenase 1 Homo sapiens 11-14 19693771-8 2009 Hb-induced IDO expression was inhibited by anti-oxidant N-acetyl-L-cysteine (NAC) or mixtures of SOD and catalase, however, IDO expression was enhanced by 3-amino-1,2,4-triazole, an inhibitor of catalase, suggesting that the generation of ROS such as O(2) (-), H(2)O(2), and hydroxyl radical is required for the induction of IDO expression. Hydroxyl Radical 275-291 indoleamine 2,3-dioxygenase 1 Homo sapiens 124-127 19693771-8 2009 Hb-induced IDO expression was inhibited by anti-oxidant N-acetyl-L-cysteine (NAC) or mixtures of SOD and catalase, however, IDO expression was enhanced by 3-amino-1,2,4-triazole, an inhibitor of catalase, suggesting that the generation of ROS such as O(2) (-), H(2)O(2), and hydroxyl radical is required for the induction of IDO expression. Hydroxyl Radical 275-291 indoleamine 2,3-dioxygenase 1 Homo sapiens 124-127 19593099-4 2009 SP acts primarily through neurokinin-1 receptors of inflammatory and endothelial cells, and may induce production of reactive oxygen and nitrogen species (superoxide anion, NO*, peroxynitrite, hydroxyl radical), leading to enhanced consumption of tissue antioxidants; stimulate release of inflammatory mediators; promote tissue adhesion molecule expression; and enhance inflammatory cell tissue infiltration and cardiovascular lesion formation. Hydroxyl Radical 193-209 tachykinin precursor 1 Homo sapiens 0-2 19576765-1 2009 Two series of drug-like BACE-1 inhibitors with a shielded tertiary hydroxyl as transition state isostere have been synthesized. Hydroxyl Radical 67-75 beta-secretase 1 Homo sapiens 24-30 19464924-1 2009 We investigated the formation of hydroxyl radical (OH(*)) and H(2)O(2) mediated oxidation products of a synthetic peptide, HCSAGIGRS, which is an active site sequence motif of protein tyrosine phosphatase 1B (PTP1B). Hydroxyl Radical 33-49 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 176-207 19561193-0 2009 Position of eukaryotic translation initiation factor eIF1A on the 40S ribosomal subunit mapped by directed hydroxyl radical probing. Hydroxyl Radical 107-123 eukaryotic translation initiation factor 1A X-linked Homo sapiens 53-58 19561193-4 2009 Here, we determined the position of eIF1A on the 40S subunit by directed hydroxyl radical cleavage. Hydroxyl Radical 73-89 eukaryotic translation initiation factor 1A X-linked Homo sapiens 36-41 19236887-4 2009 Cd-generated superoxide anion, hydrogen peroxide, and hydroxyl radicals in vivo have been detected by the electron spin resonance spectra, which are often accompanied by activation of redox sensitive transcription factors (e.g., NF-kappaB, AP-1 and Nrf2) and alteration of ROS-related gene expression. Hydroxyl Radical 54-71 NFE2 like bZIP transcription factor 2 Homo sapiens 249-253 19457062-2 2009 This binding was shown to protect ApoA-I against hydroxyl radicals, thus preventing loss of ApoA-I function in enzyme stimulation. Hydroxyl Radical 49-66 apolipoprotein A1 Homo sapiens 34-40 19457062-2 2009 This binding was shown to protect ApoA-I against hydroxyl radicals, thus preventing loss of ApoA-I function in enzyme stimulation. Hydroxyl Radical 49-66 apolipoprotein A1 Homo sapiens 92-98 19457062-5 2009 Hydroxyl radicals promoted in vitro the formation of ApoE-containing adducts which were detected by immunoblotting. Hydroxyl Radical 0-17 apolipoprotein E Homo sapiens 53-57 19198902-7 2009 In order to elucidate the physical origins of this phenomenon, i.e. to analyze how the modification of adenine by hydroxyl radical is reflected in the change of intermolecular interaction energy components, a variational-perturbational decomposition scheme was applied at the MP2/aug-cc-pVDZ level of theory. Hydroxyl Radical 114-130 tryptase pseudogene 1 Homo sapiens 276-279 19563754-3 2009 NPC2 binds cholesterol with its isooctyl side chain buried and its 3beta-hydroxyl exposed. Hydroxyl Radical 73-81 NPC intracellular cholesterol transporter 2 Homo sapiens 0-4 19323556-2 2009 The linear hydroxyl-terminated PCL (PCL-OH) was synthesized by controlled ROP of epsilon-caprolactone and then transformed into clickable azide-terminated PCL (PCL-N(3)). Hydroxyl Radical 11-19 PHD finger protein 1 Homo sapiens 31-34 19358607-4 2009 This radical appears to arise from ethanol oxidation via the hydroxyl radical, and this latter species was confirmed by using a high concentration (1.5 M) of the 5,5-dimethylpyrroline-N-oxide spin trap, thus providing the first direct evidence of the Fenton reaction in wine. Hydroxyl Radical 61-77 spindlin 1 Homo sapiens 192-196 19323556-2 2009 The linear hydroxyl-terminated PCL (PCL-OH) was synthesized by controlled ROP of epsilon-caprolactone and then transformed into clickable azide-terminated PCL (PCL-N(3)). Hydroxyl Radical 11-19 PHD finger protein 1 Homo sapiens 36-39 19323556-2 2009 The linear hydroxyl-terminated PCL (PCL-OH) was synthesized by controlled ROP of epsilon-caprolactone and then transformed into clickable azide-terminated PCL (PCL-N(3)). Hydroxyl Radical 11-19 PHD finger protein 1 Homo sapiens 36-39 19323556-2 2009 The linear hydroxyl-terminated PCL (PCL-OH) was synthesized by controlled ROP of epsilon-caprolactone and then transformed into clickable azide-terminated PCL (PCL-N(3)). Hydroxyl Radical 11-19 PHD finger protein 1 Homo sapiens 160-168 19243126-6 2009 Kinetic analyses of hydrogen peroxide consumption and of nitrite, formate, and bicarbonate-carbon dioxide oxidation showed that the Sod1-bound hydroxyl-like oxidant functions in the presence of nitrite and formate. Hydroxyl Radical 143-151 superoxide dismutase 1 Homo sapiens 132-136 19114730-5 2009 Phosphatidylcholine hydroxide (a hydroxyl analog of PCOOH) also induced THP-1 cell adhesion to ICAM-1, whereas nonoxidized PC, sn-2 truncated PCs, and other hydroperoxide compounds did not affect the adhesion. Hydroxyl Radical 33-41 GLI family zinc finger 2 Homo sapiens 72-77 19114730-5 2009 Phosphatidylcholine hydroxide (a hydroxyl analog of PCOOH) also induced THP-1 cell adhesion to ICAM-1, whereas nonoxidized PC, sn-2 truncated PCs, and other hydroperoxide compounds did not affect the adhesion. Hydroxyl Radical 33-41 intercellular adhesion molecule 1 Homo sapiens 95-101 19377484-4 2009 Using an RNA-mediated hydroxyl radical probing method and mass spectrometry, we mapped a discrete region of the WD repeat domain that contacts snRNAs and demonstrated by mutagenesis that specific amino acids in this region are crucial for Gemin5-snRNA binding. Hydroxyl Radical 22-38 gem nuclear organelle associated protein 5 Homo sapiens 239-245 19233261-10 2009 Intervention studies with known reactive oxygen species (ROS) modifiers suggested that H(2)O(2), singlet oxygen, hydroxyl radical, and superoxide may also be involved in this PCB-mediated oxidative DNA damage. Hydroxyl Radical 113-129 pyruvate carboxylase Homo sapiens 175-178 19380834-8 2009 We observed that s.c. peroxynitrites induced skin fibrosis and serum anti-CENP-B Abs that characterize limited SSc, whereas hypochlorite or hydroxyl radicals induced cutaneous and lung fibrosis and anti-DNA topoisomerase 1 autoantibodies that characterize human diffuse SSc. Hydroxyl Radical 140-157 DNA topoisomerase I Homo sapiens 203-222 19380834-9 2009 Sera from hypochlorite- or hydroxyl radical-treated mice and of patients with diffuse SSc contained high levels of AOPP that triggered endothelial production of H(2)O(2) and fibroblast hyperproliferation. Hydroxyl Radical 27-43 peroxiredoxin 5 Mus musculus 115-119 19280425-7 2009 In addition, phosphine and hydrogen peroxide can interact to form the highly reactive hydroxyl radical and phosphine also inhibits catalase and peroxidase; both mechanisms result in hydroxyl radical associated damage such as lipid peroxidation. Hydroxyl Radical 86-102 catalase Homo sapiens 131-139 19475990-2 2009 An alpha-ethano bridge is required; an alpha- or beta-methoxy or hydroxyl H-bond acceptor are all tolerated at C-3; a small substituent (H, or OH) alone is tolerated at C-11; and a C-1 to C-2 double bond is shown to modulate, but is not a requirement for, apoptosis-inducing activity. Hydroxyl Radical 65-73 complement C3 Homo sapiens 111-114 19103263-5 2009 The ascorbate/Cu(2+)-mediated inactivation of PON1 lactonase activity was prevented by catalase, but not general hydroxyl radical scavengers, suggesting the implication of Cu(2+)-bound hydroxyl radicals in the oxidative inactivation. Hydroxyl Radical 113-129 paraoxonase 1 Homo sapiens 46-50 19103263-5 2009 The ascorbate/Cu(2+)-mediated inactivation of PON1 lactonase activity was prevented by catalase, but not general hydroxyl radical scavengers, suggesting the implication of Cu(2+)-bound hydroxyl radicals in the oxidative inactivation. Hydroxyl Radical 185-202 paraoxonase 1 Homo sapiens 46-50 19103263-5 2009 The ascorbate/Cu(2+)-mediated inactivation of PON1 lactonase activity was prevented by catalase, but not general hydroxyl radical scavengers, suggesting the implication of Cu(2+)-bound hydroxyl radicals in the oxidative inactivation. Hydroxyl Radical 185-202 catalase Homo sapiens 87-95 19374861-3 2009 The rise in both the core temperature and hypothalamic glutamate, hydroxyl radicals and prostaglandin-E(2) could also be induced by intracerebroventricular injection of interleukin-6. Hydroxyl Radical 66-83 interleukin-6 Oryctolagus cuniculus 169-182 19350924-5 2009 LC-MS analyses indicate the major products from the reaction of hydroxyl radicals with MC-LR involve addition of hydroxyl radical to the benzene ring and diene moieties of the Adda side chain. Hydroxyl Radical 64-81 adducin 1 Homo sapiens 176-180 19350924-5 2009 LC-MS analyses indicate the major products from the reaction of hydroxyl radicals with MC-LR involve addition of hydroxyl radical to the benzene ring and diene moieties of the Adda side chain. Hydroxyl Radical 64-80 adducin 1 Homo sapiens 176-180 19350924-11 2009 The relative magnitude of the rate constants for the reactions of hydroxyl radical with the individual amino acids and appropriate surrogates, suggest 60-70% reactions of hydroxyl radical occur at the benzene and diene functional groups of the Adda moiety. Hydroxyl Radical 66-82 adducin 1 Homo sapiens 244-248 19350924-11 2009 The relative magnitude of the rate constants for the reactions of hydroxyl radical with the individual amino acids and appropriate surrogates, suggest 60-70% reactions of hydroxyl radical occur at the benzene and diene functional groups of the Adda moiety. Hydroxyl Radical 171-187 adducin 1 Homo sapiens 244-248 19085183-0 2009 Characterization of hydroxyl radical modified GAD65: a potential autoantigen in type 1 diabetes. Hydroxyl Radical 20-36 glutamate decarboxylase 2 Homo sapiens 46-51 19085183-3 2009 In search of a potential immunological marker of type 1 diabetes, in vitro GAD(65) was modified by hydroxyl radical followed by the study of structural and conformational perturbed protein by different spectroscopic techniques (UV, fluorescence and CD) and thermal denaturation profile. Hydroxyl Radical 99-115 glutamate decarboxylase 2 Homo sapiens 75-82 18814910-8 2009 Intracellular but not extracellular application of FeSO(4), which catalyses the formation of highly reactive hydroxyl radicals potentiated the hydrogen peroxide-stimulated TRPA1 activation. Hydroxyl Radical 109-126 transient receptor potential cation channel subfamily A member 1 Homo sapiens 172-177 19280425-7 2009 In addition, phosphine and hydrogen peroxide can interact to form the highly reactive hydroxyl radical and phosphine also inhibits catalase and peroxidase; both mechanisms result in hydroxyl radical associated damage such as lipid peroxidation. Hydroxyl Radical 182-198 catalase Homo sapiens 131-139 19097798-1 2009 Three series of non-steroidal anti-inflammatory drugs (NSAIDs) inhibiting the cyclooxygenase/5-lipoxygenase (COX/5-LOX) pathways as such as formation of hydroxyl radicals and adhesion were prepared: 4,5-diaryl isothiazoles, 4,5-diaryl 3H-1,2-dithiole-3-thiones and 4,5-diaryl 3H-1,2-dithiole-3-ones. Hydroxyl Radical 153-170 lysyl oxidase Mus musculus 115-118 19015023-6 2009 O(2)(-) inactivates mitochondrial aconitase to release iron from iron-sulfur clusters, which forms the hydroxyl radical ((. Hydroxyl Radical 103-119 aconitase 2 Homo sapiens 20-43 19056279-3 2009 Deoxygenation at either the C-2 or C-3 position of Araf was achieved via a free radical procedure using xanthate derivatives of the hydroxyl group. Hydroxyl Radical 132-140 A-Raf proto-oncogene, serine/threonine kinase Homo sapiens 51-55 19061417-3 2009 Chymotrypsin digestion indicated that the rod (tail) subfragment of myosin was the preferred target of hydroxyl radicals and ferryl oxygen species, although the s-1 (head) region was also susceptible. Hydroxyl Radical 103-120 myosin heavy chain 14 Homo sapiens 68-74 18854902-6 2008 The results indicate that Co(II) binds O2 in the presence of GGH, and leads to the formation of a DMPO-HO adduct without first forming free superoxide or hydroxyl radical, supporting the participation of a reactive high-valent cobalt complex. Hydroxyl Radical 154-170 mitochondrially encoded cytochrome c oxidase II Homo sapiens 26-32 19232047-5 2009 Using infrared spectroscopy, it has been shown that free radical oxidation of amino acid residues of fibrinogen polypeptide chains catalyzed by ozone results in formation of carbonyl, hydroxyl, and ether groups. Hydroxyl Radical 184-192 fibrinogen beta chain Homo sapiens 101-111 19273067-3 2009 Reactive oxygen species (ROS) (e.g., superoxide, peroxynitrite, hydroxyl radical and hydrogen peroxide) are all potential reactants capable of initiating DNA single strand breakage, with subsequent activation of the nuclear enzyme poly (ADP ribose) synthetase (PARS), leading to eventual severe energy depletion of the cells, and necrotic-type cell death. Hydroxyl Radical 64-80 poly(ADP-ribose) polymerase 1 Homo sapiens 231-259 19607981-2 2009 Superoxide anion is converted by superoxide dismutase into hydrogen peroxide (H2O2), and the latter is then transformed into the toxic hydroxyl radical, through the Haber-Weiss reaction, converted to water by glutathione peroxidase (GPx) or dismuted to water and oxygen through catalase. Hydroxyl Radical 135-151 catalase Rattus norvegicus 278-286 19149670-0 2009 Hydroxyl radical mediates oxidative modification of caprine alpha-2 macroglobulin. Hydroxyl Radical 0-16 alpha-2-macroglobulin Homo sapiens 60-81 19542619-7 2009 Interestingly, vitamin C was found to be selective in the scavenging activity, suggesting that expression of truncated tau protein preferentially leads to increases in aqueous phase oxidants and free radicals such as hydrogen peroxide and hydroxyl and superoxide radicals. Hydroxyl Radical 239-247 microtubule associated protein tau Homo sapiens 119-122 18790849-16 2008 We conclude that KCNQ3 homomers are well expressed at the plasma membrane, but that most wild-type channels are functionally silent, with rearrangements of the pore-loop architecture induced by the presence of a hydroxyl-containing residue at the 315 position "unlocking" the channels into a conductive conformation. Hydroxyl Radical 212-220 potassium voltage-gated channel subfamily Q member 3 Homo sapiens 17-22 19192812-7 2008 Isomerization at the C4-C5 and C6-C7 of the diene bond of the Adda chain was a direct result of hydroxyl radical addition/substitution. Hydroxyl Radical 96-112 adducin 1 Homo sapiens 62-66 19186803-1 2008 Alb species [Al12 AlO4 (OH)24(7+)] is multinuclear hydroxyl compound formed in PAC hydrolysis-polymerization process, with properties of small particle sizes, much positive charge, high aggregation degree and large molecular weight. Hydroxyl Radical 51-59 albumin Homo sapiens 0-3 18847222-8 2008 Abeta does not silence the redox activity of Cu(2+/+) via chelation, but rather hydroxyl radicals produced as a result of Fenton-Haber Weiss reactions of ascorbate and Cu(2+) rapidly react with Abeta; thus the potentially harmful radicals are quenched. Hydroxyl Radical 80-97 amyloid beta precursor protein Homo sapiens 0-5 18847222-8 2008 Abeta does not silence the redox activity of Cu(2+/+) via chelation, but rather hydroxyl radicals produced as a result of Fenton-Haber Weiss reactions of ascorbate and Cu(2+) rapidly react with Abeta; thus the potentially harmful radicals are quenched. Hydroxyl Radical 80-97 amyloid beta precursor protein Homo sapiens 194-199 18707901-0 2008 Quantifying protein interface footprinting by hydroxyl radical oxidation and molecular dynamics simulation: application to galectin-1. Hydroxyl Radical 46-62 galectin 1 Homo sapiens 123-133 18664365-5 2008 The rise in both the core temperature and hypothalamic glutamate and hydroxyl radicals could also be induced by direct injection of TNF-alpha, IL-1beta, or IL-6 into the lateral ventricle of rabbit brain. Hydroxyl Radical 69-86 tumor necrosis factor Oryctolagus cuniculus 132-141 18767865-4 2008 In order to study the reactivity of the C-9 hydroxyl function in 5 and in the previously investigated allenic triol 2, two model compounds, megastigma-4,6,7-trien-9-ol (7) and megastigma-6,7-dien-9-ol (8) were synthesized. Hydroxyl Radical 44-52 complement C9 Homo sapiens 40-43 18555026-6 2008 When both hydroxyl and superoxide free radicals were generated during water radiolysis, only five tryptic peptides of cyt c were reproducibly identified as oxidized according to a relation that was dependent of the dose of ionizing radiation. Hydroxyl Radical 10-18 cytochrome c, somatic Homo sapiens 118-123 18555026-9 2008 In addition, the enzymatic site of cytochrome c was sensitive to the attack of both superoxide and hydroxyl radicals as observed through the reduction of Fe(3+), the degradation of the protoporphyrin IX and the oxidative disruption of the Met80-Fe(3+) bond. Hydroxyl Radical 99-116 cytochrome c, somatic Homo sapiens 35-47 18664365-5 2008 The rise in both the core temperature and hypothalamic glutamate and hydroxyl radicals could also be induced by direct injection of TNF-alpha, IL-1beta, or IL-6 into the lateral ventricle of rabbit brain. Hydroxyl Radical 69-86 interleukin-1 beta Oryctolagus cuniculus 143-151 18664365-5 2008 The rise in both the core temperature and hypothalamic glutamate and hydroxyl radicals could also be induced by direct injection of TNF-alpha, IL-1beta, or IL-6 into the lateral ventricle of rabbit brain. Hydroxyl Radical 69-86 interleukin-6 Oryctolagus cuniculus 156-160 18664365-9 2008 Both the febrile response and overproduction of both glutamate and hydroxyl radicals in the hypothalamus caused by central administration of TNF-alpha, IL-1beta, or IL-6 could be suppressed by Curcumin. Hydroxyl Radical 67-84 tumor necrosis factor Oryctolagus cuniculus 141-150 18664365-9 2008 Both the febrile response and overproduction of both glutamate and hydroxyl radicals in the hypothalamus caused by central administration of TNF-alpha, IL-1beta, or IL-6 could be suppressed by Curcumin. Hydroxyl Radical 67-84 interleukin-1 beta Oryctolagus cuniculus 152-160 18664365-9 2008 Both the febrile response and overproduction of both glutamate and hydroxyl radicals in the hypothalamus caused by central administration of TNF-alpha, IL-1beta, or IL-6 could be suppressed by Curcumin. Hydroxyl Radical 67-84 interleukin-6 Oryctolagus cuniculus 165-169 18620046-0 2008 Involvement of inducible nitric oxide synthase in hydroxyl radical-mediated lipid peroxidation in streptozotocin-induced diabetes. Hydroxyl Radical 50-66 nitric oxide synthase 2 Rattus norvegicus 15-46 18620046-9 2008 The specific iNOS inhibitor 1400W as well as L-arginine pretreatment reduced the EPR signals to baseline levels, implicating peroxynitrite as the source of hydroxyl radical production. Hydroxyl Radical 156-172 nitric oxide synthase 2 Rattus norvegicus 13-17 18321644-6 2008 Hydroxyl radicals reacted with the azo linkage-bearing carbon of a hydroxy-substituted ring, leading to the cleavage of -C-N- and degradation of AO7. Hydroxyl Radical 0-17 ring finger protein 25 Homo sapiens 145-148 18712632-4 2008 The results show that alpha(1)-microglobulin prevents intracellular oxidation and up-regulation of heme oxygenase-1 induced by heme, hydrogen peroxide and Fenton reaction-generated hydroxyl radicals in the culture medium. Hydroxyl Radical 181-198 heme oxygenase 1 Homo sapiens 99-115 18719440-3 2008 METHODS: The authors investigated the effects of propofol MCT/LCT on reactive oxygen species (hydroxyl radical or superoxide) by electron spin resonance spin trapping with 5,5-dimethyl-1-pyrroline-N-oxide. Hydroxyl Radical 94-110 lactase Rattus norvegicus 62-65 18719440-5 2008 RESULTS: These studies provided direct evidence that propofol MCT/LCT inhibited hydroxyl radical generation, but not superoxide generation. Hydroxyl Radical 80-96 lactase Rattus norvegicus 66-69 18719440-8 2008 CONCLUSION: The current data show that propofol, mixed with clinical reagents (propofol MCT/LCT), resulted in the down-regulation of high oxidative stress due to scavenging hydroxyl radical, as demonstrated by in vitro or in vivo electron spin resonance analysis. Hydroxyl Radical 173-189 lactase Rattus norvegicus 92-95 19060937-3 2008 The conjugates were synthesized using a method that consists of the generation of aldehyde groups by oxidizing free vicinal hydroxyl groups of PsA and subsequent reaction of these groups with amino groups of the peptide. Hydroxyl Radical 124-132 aminopeptidase puromycin sensitive Homo sapiens 143-146 18582436-3 2008 In this study, we found that 4-alpha-cumylphenol lacking one of its phenol-hydroxyl groups also binds to ERRgamma very strongly. Hydroxyl Radical 75-83 estrogen related receptor gamma Homo sapiens 105-113 18729091-2 2008 Prior studies with purified human cytochrome b(5) and NADPH:P450 reductase in reconstituted proteoliposomes (PLs) demonstrated rapid reduction of Cr(VI) (hexavalent chromium, as CrO(4)(2-), and the generation of Cr(V), superoxide (O(2)(*-)), and hydroxyl radical (HO(*)). Hydroxyl Radical 246-262 cytochrome b5 type A Homo sapiens 34-49 18729091-2 2008 Prior studies with purified human cytochrome b(5) and NADPH:P450 reductase in reconstituted proteoliposomes (PLs) demonstrated rapid reduction of Cr(VI) (hexavalent chromium, as CrO(4)(2-), and the generation of Cr(V), superoxide (O(2)(*-)), and hydroxyl radical (HO(*)). Hydroxyl Radical 246-262 2,4-dienoyl-CoA reductase 1 Homo sapiens 54-74 17869416-4 2008 Bulk electrolysis results showed that the electrochemical process was suitable for completely removing COD and effectively decolourising wastewaters, due to the production of hydroxyl radicals on the diamond surface. Hydroxyl Radical 175-192 small nuclear ribonucleoprotein polypeptides B and B1 Homo sapiens 103-106 18482604-0 2008 Hydroxyl radical scavenging assay of phenolics and flavonoids with a modified cupric reducing antioxidant capacity (CUPRAC) method using catalase for hydrogen peroxide degradation. Hydroxyl Radical 0-16 catalase Homo sapiens 137-145 18569016-4 2008 The results showed that chronic insulin treatment significantly increased the intracellular generation of superoxide anion, hydrogen peroxide and hydroxyl radical. Hydroxyl Radical 146-162 insulin Homo sapiens 32-39 18282684-9 2008 MDR1 expression and drug sensitivity were restored to control values when mannitol (a hydroxyl radical scavenger) was co-administrated. Hydroxyl Radical 86-102 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 18289828-5 2008 In particular, monoalkylphenols having a 6-9 carbon alkyl group para to the phenolic hydroxyl group possessed high affinity for the RAR gamma, and their activities were 1.363-0.446% of that of all-trans RA. Hydroxyl Radical 85-93 retinoic acid receptor gamma Homo sapiens 132-141 18404779-1 2008 The aim was to study the COX-1 inhibiting efficacy in context with hydroxyl radical scavenging properties of compounds bearing a carboxylic acid and ester function, respectively. Hydroxyl Radical 67-83 mitochondrially encoded cytochrome c oxidase I Homo sapiens 25-30 17976864-2 2008 Here we describe the synthesis of COX/LOX inhibitors which additionally reduce the level of reactive oxygen species, such as hydroxyl radicals which are well known for supporting inflammation processes in Parkinson"s disease, Alzheimer"s disease and rheumatoid arthritis. Hydroxyl Radical 125-142 lysyl oxidase Homo sapiens 38-41 18378446-2 2008 Among them, hydroxyl containing analog 31 displayed excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized IV rat model. Hydroxyl Radical 12-20 gonadotropin releasing hormone receptor Rattus norvegicus 100-102 18263714-9 2008 In addition, Aspergillus niger catalase, which breaks down H(2)O(2), as well as hydroxyl radical scavengers, which included hydroquinone and mannitol, prevented the effect of Lzm-S. Hydroxyl Radical 80-96 MAA Homo sapiens 175-180 18078827-6 2008 CYP2E1 is also an effective generator of reactive oxygen species such as the superoxide anion radical and hydrogen peroxide and, in the presence of iron catalysts, produces powerful oxidants such as the hydroxyl radical. Hydroxyl Radical 203-219 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 0-6 18296683-7 2008 We have applied this method to a mixed set of mutation spectra observed in exons 5, 7 and 8 of TP53 from cancers of brain, breast, skin, colon, oesophagus, liver, head and neck, stomach and lung (smokers and non-smokers) and spectra induced by benzo[a]pyrene diol epoxide, ultraviolet (UV) B, UVC, simulated sunlight and hydroxyl radicals in the cII, supF and yeast p53 model systems. Hydroxyl Radical 321-338 tumor protein p53 Homo sapiens 95-99 18249549-6 2008 In general, hydroxyl derivatives derived from more constrained bicyclic diamines exhibited greater selectivity for interaction with DAT compared to the corresponding 3,6-disubstituted diamines. Hydroxyl Radical 12-20 solute carrier family 6 member 3 Homo sapiens 132-135 18404574-2 2008 Although all synthesized compounds were totally devoid of binding affinity at the human A3AR, our results revealed that 3"-position of adenosine can only be tolerated with small size of a hydrogen bonding donor like hydroxyl or amino group in the binding site of human A3AR. Hydroxyl Radical 216-224 adenosine A3 receptor Homo sapiens 269-273 18045581-4 2008 The results showed that the treatment of SNE significantly lowered the CCl4-induced serum levels of hepatic enzyme markers (GOT, GPT, ALP, and total bilirubin), superoxide and hydroxyl radical. Hydroxyl Radical 176-192 C-C motif chemokine ligand 4 Rattus norvegicus 71-75 18068745-3 2008 In the process that acts as a "chemical shield," the phenolic A-ring turns into 10beta-hydroxy-17beta-butoxy-1,3,5(10)-estratrien-3-one, a non-aromatic para-quinol, upon capturing hydroxyl radicals, which results in the complete loss of estrogen-receptor affinity and antioxidant activity. Hydroxyl Radical 180-197 estrogen receptor 1 Homo sapiens 237-254 18162582-4 2008 Microarray analysis showed that Isc1p deficiency up-regulated the iron regulon leading to increased levels of iron, which is known to catalyze the production of the highly reactive hydroxyl radicals via the Fenton reaction. Hydroxyl Radical 181-198 inositol phosphosphingolipid phospholipase Saccharomyces cerevisiae S288C 32-37 18155048-4 2008 In this study, directed hydroxyl radical probing mediated by Fe(II)-derivatized S20 proteins was used to monitor the folding of 16S rRNA during r-protein association and 30S subunit assembly. Hydroxyl Radical 24-40 ribosomal protein S20 Homo sapiens 80-83 18313326-8 2008 In the electron spin resonance study, Abeta (2 and 10 microM) markedly triggered hydroxyl radical formation in platelets. Hydroxyl Radical 81-97 amyloid beta precursor protein Homo sapiens 38-43 17999630-3 2008 The superoxide dismutases (SOD) are a family of enzymes that play a pivotal role protecting tissues from damage by oxidant stress by scavenging superoxide anion, which prevents the formation of other more potent oxidants such as peroxynitrite and hydroxyl radical. Hydroxyl Radical 247-263 superoxide dismutase 3 Homo sapiens 27-30 18537206-2 2008 Firstly, PCL cross-linkers were produced by ring-opening polymerization (ROP) of epsilon-CL initiated by 1,4-butane-diol and catalyzed by tin(II) 2-ethylhexanoate ([Sn(Oct)2]), followed by the quantitative esterification reaction of terminal hydroxyl end-groups with methacrylic anhydride. Hydroxyl Radical 242-250 PHD finger protein 1 Homo sapiens 9-12 18540477-5 2008 MAO participates in the generation of hydroxyl radicals during ischemia/reperfusion. Hydroxyl Radical 38-55 monoamine oxidase A Rattus norvegicus 0-3 18289003-3 2008 Reactive oxygen species (ROS) (e.g., superoxide, peroxynitrite, hydroxyl radical and hydrogen peroxide) are all potential reactants capable of initiating DNA single strand breakage, with subsequent activation of the nuclear enzyme poly (ADP ribose) synthetase (PARS), leading to eventual severe energy depletion of the cells, and necrotic-type cell death. Hydroxyl Radical 64-80 poly(ADP-ribose) polymerase 1 Homo sapiens 231-259 18197296-8 2008 When we examined BPA derivatives to evaluate the structural essentials required for the binding of BPA to ERR-gamma , we found that only one of the two phenol-hydroxyl groups was essential for the full binding. Hydroxyl Radical 159-167 estrogen related receptor gamma Homo sapiens 106-115 17920716-1 2008 We examined whether central or peripheral administration of interleukin-1beta (IL-1beta) might change levels of nitric oxide (NO) and hydroxyl radical (*OH) in the medial prefrontal cortex (mPFC). Hydroxyl Radical 134-150 interleukin 1 beta Rattus norvegicus 60-77 18052220-6 2008 In the presence of NaF, hydroxyl radicals were detected by an ethanol scavenger, whereas such radicals were not found in the absence of NaF. Hydroxyl Radical 24-41 C-X-C motif chemokine ligand 8 Homo sapiens 19-22 17920716-1 2008 We examined whether central or peripheral administration of interleukin-1beta (IL-1beta) might change levels of nitric oxide (NO) and hydroxyl radical (*OH) in the medial prefrontal cortex (mPFC). Hydroxyl Radical 134-150 interleukin 1 beta Rattus norvegicus 79-87 17719074-0 2008 Reactions of thiocarbamate, triazine and urea herbicides, RDX and benzenes on EPA Contaminant Candidate List with ozone and with hydroxyl radicals. Hydroxyl Radical 129-146 radixin Homo sapiens 58-61 17949766-6 2008 Structural analysis of the NCI 122-ERalpha LBD-GRIP1 complex, combined with biochemical and cell-based comparisons of CEE components, suggests that factors such as decreased ligand flexibility, decreased ligand hydrophobicity and loss of a hydrogen bond between the 17-hydroxyl group and His524, contribute significantly to the reduced potency of CEEs on ERalpha. Hydroxyl Radical 269-277 glutamate receptor interacting protein 1 Equus caballus 47-52 19192719-2 2008 NHE water diminished hydroxyl radicals as demonstrated by ESR in a cell-free system. Hydroxyl Radical 21-38 solute carrier family 9 member C1 Homo sapiens 0-3 17898123-2 2007 In this context, whether ET-1 modulates hydroxyl radical (*OH) formation and the function of ROS/*OH in obesity is not known. Hydroxyl Radical 40-56 endothelin 1 Mus musculus 25-29 18068622-3 2007 METHODS AND RESULTS: By using a rabbit model of ischemia-reperfusion injury, we demonstrate that HGF gene transfer is cardioprotective through its multiple beneficial actions, such as angiogenesis, Bcl-2 overexpression, and decreasing hydroxyl radicals, deoxyuride-5"-triphosphate biotin nick end labeling (TUNEL)-positive myocytes, and fibrotic area. Hydroxyl Radical 235-252 hepatocyte growth factor Oryctolagus cuniculus 97-100 18071267-0 2007 Superoxide dismutase enhanced the formation of hydroxyl radicals in a reaction mixture containing xanthone under UVA irradiation. Hydroxyl Radical 47-64 superoxide dismutase 1 Homo sapiens 0-20 18071267-1 2007 To clarify the effect of superoxide dismutase (SOD) on the formation of hydroxyl radical in a standard reaction mixture containing 15 microM of xanthone, 0.1 M of 5,5-dimethyl-1-pyrroline N-oxide (DMPO), and 45 mM of phosphate buffer (pH 7.4) under UVA irradiation, electron paramagnetic resonance (EPR) measurements were performed. Hydroxyl Radical 72-88 superoxide dismutase 1 Homo sapiens 25-45 18071267-1 2007 To clarify the effect of superoxide dismutase (SOD) on the formation of hydroxyl radical in a standard reaction mixture containing 15 microM of xanthone, 0.1 M of 5,5-dimethyl-1-pyrroline N-oxide (DMPO), and 45 mM of phosphate buffer (pH 7.4) under UVA irradiation, electron paramagnetic resonance (EPR) measurements were performed. Hydroxyl Radical 72-88 superoxide dismutase 1 Homo sapiens 47-50 18071267-2 2007 SOD enhanced the formation of hydroxyl radicals. Hydroxyl Radical 30-47 superoxide dismutase 1 Homo sapiens 0-3 18071267-3 2007 The formation of hydroxyl radicals was inhibited on the addition of catalase. Hydroxyl Radical 17-34 catalase Homo sapiens 68-76 18071267-6 2007 SOD possibly enhances the formation of the hydroxyl radical in reaction mixtures of photosensitizers that can produce O(2)(-. Hydroxyl Radical 43-59 superoxide dismutase 1 Homo sapiens 0-3 17824618-11 2007 Therefore haptoglobin, when circulating at enhanced levels with free Hb during the acute phase of inflammation, might protect ApoA-I structure and function against hydroxyl radicals. Hydroxyl Radical 164-181 haptoglobin Homo sapiens 10-21 17966041-3 2007 Therefore, we hypothesized that oxidative by-products, such as hydroxyl radical (*OH), could lead to neoantigens like *OH damaged human serum albumin (HSA), which could in turn initiate autoimmunity in SLE. Hydroxyl Radical 63-79 albumin Homo sapiens 136-149 17562166-4 2007 In addition, H(2)O(2) seems to activate TRPM2 by changing to the hydroxyl radical in the intracellular space after passing the plasma membrane. Hydroxyl Radical 65-81 transient receptor potential cation channel subfamily M member 2 Cricetulus griseus 40-45 17620452-6 2007 Pretreatment of cells with the antioxidant enzyme catalase and the intracellular hydroxyl scavenger dimethylthiourea (DMTU) abrogated the thalidomide-induced p38 MAPK activation and histone H4 acetylation. Hydroxyl Radical 81-89 mitogen-activated protein kinase 14 Homo sapiens 158-161 17824618-0 2007 Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase. Hydroxyl Radical 63-80 haptoglobin Homo sapiens 0-11 17824618-0 2007 Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase. Hydroxyl Radical 63-80 apolipoprotein A1 Homo sapiens 23-41 17824618-1 2007 Apolipoprotein A-I (ApoA-I), a major component of HDL, binds haptoglobin, a plasma protein transporting to liver or macrophages free Hb for preventing hydroxyl radical production. Hydroxyl Radical 151-167 apolipoprotein A1 Homo sapiens 0-18 17824618-1 2007 Apolipoprotein A-I (ApoA-I), a major component of HDL, binds haptoglobin, a plasma protein transporting to liver or macrophages free Hb for preventing hydroxyl radical production. Hydroxyl Radical 151-167 apolipoprotein A1 Homo sapiens 20-26 17824618-1 2007 Apolipoprotein A-I (ApoA-I), a major component of HDL, binds haptoglobin, a plasma protein transporting to liver or macrophages free Hb for preventing hydroxyl radical production. Hydroxyl Radical 151-167 haptoglobin Homo sapiens 61-72 17824618-3 2007 Human ApoA-I structure, as analyzed by electrophoresis and MS, was found severely altered by hydroxyl radicals in vitro. Hydroxyl Radical 93-110 apolipoprotein A1 Homo sapiens 6-12 17824618-5 2007 ApoA-I oxidation was limited also when the complex of haptoglobin with both high-density lipoprotein and Hb, immobilized on resin beads, was exposed to hydroxyl radicals. Hydroxyl Radical 152-169 apolipoprotein A1 Homo sapiens 0-6 17628631-2 2007 The UVC-photolysis (254 nm) of H2O2 added to aqueous solutions of CCl4 is leading to the homolysis of the oxidant yielding hydroxyl radicals (HO) that subsequently react with added methanol to generate hydroxymethyl radicals (CH2OH). Hydroxyl Radical 123-140 C-C motif chemokine ligand 4 Homo sapiens 66-70 17824618-5 2007 ApoA-I oxidation was limited also when the complex of haptoglobin with both high-density lipoprotein and Hb, immobilized on resin beads, was exposed to hydroxyl radicals. Hydroxyl Radical 152-169 haptoglobin Homo sapiens 54-65 17628631-2 2007 The UVC-photolysis (254 nm) of H2O2 added to aqueous solutions of CCl4 is leading to the homolysis of the oxidant yielding hydroxyl radicals (HO) that subsequently react with added methanol to generate hydroxymethyl radicals (CH2OH). Hydroxyl Radical 142-144 C-C motif chemokine ligand 4 Homo sapiens 66-70 17697940-2 2007 Using alkaline single-cell gel electrophoresis (the Comet assay), we show that expression of PrPC protects human neuroblastoma SH-SY5Y cells against DNA damage under basal conditions and following exposure to reactive oxygen species, either hydroxyl radicals following exposure to Cu2+ or Fe2+ or singlet oxygen following exposure to the photosensitizer methylene blue and white light. Hydroxyl Radical 241-258 prion protein Homo sapiens 93-97 17652444-3 2007 The methoxyl substitution produced an agonist 4-butoxy-N-[2-(4-methoxy-phenyl)-4-oxo-1,4-dihydro-2H-quinazolin-3-yl]-benzamide (Quin-C1; C1), whereas a hydroxyl substitution resulted in a pure antagonist, Quin-C7 (C7). Hydroxyl Radical 152-160 complement C7 Homo sapiens 205-212 17652444-3 2007 The methoxyl substitution produced an agonist 4-butoxy-N-[2-(4-methoxy-phenyl)-4-oxo-1,4-dihydro-2H-quinazolin-3-yl]-benzamide (Quin-C1; C1), whereas a hydroxyl substitution resulted in a pure antagonist, Quin-C7 (C7). Hydroxyl Radical 152-160 complement C7 Homo sapiens 210-212 17934344-2 2007 To answer this question, we investigated whether ischemic preconditioning in the hippocampal CA1 region increases the activities of antioxidant enzymes glutathione peroxidase and catalase, resulting in a decrease in the level of hydroxyl radicals during subsequent severe ischemia-reperfusion. Hydroxyl Radical 229-246 carbonic anhydrase 1 Rattus norvegicus 93-96 17659301-11 2007 Finally, stimulation of VSMC with hydroxyl radicals increased expression of GKLF and p53 and reduced cell proliferation. Hydroxyl Radical 34-51 Kruppel like factor 4 Rattus norvegicus 76-80 17659301-11 2007 Finally, stimulation of VSMC with hydroxyl radicals increased expression of GKLF and p53 and reduced cell proliferation. Hydroxyl Radical 34-51 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 85-88 17485497-11 2007 The most abundant metabolite in feces was a hydroxyl metabolite, H-1, which accounted for 4.9% of fecal radioactivity. Hydroxyl Radical 44-52 H1.5 linker histone, cluster member Homo sapiens 65-68 17646889-1 2007 The lactonisation of a CCR1 inhibitor (CC chemokine receptor 1, involved in autoimmune diseases) featuring a hydroxyl group in a gamma-position (gamma-OH) with respect to an amide group has been investigated in silico. Hydroxyl Radical 109-117 C-C motif chemokine receptor 1 Homo sapiens 23-27 17566136-2 2007 The reaction is a complex process that involves, in the first stage, a pre-reactive hydrogen-bonded complex (C1), which is formed previous to two transition states (TS1 and TS2) involving the addition of the hydroxyl radical to ozone, and leads to the formation of HO4 polyoxide radical before the release of the products HO2 and O2. Hydroxyl Radical 208-224 heme oxygenase 2 Homo sapiens 322-325 17568775-0 2007 Position of eukaryotic initiation factor eIF5B on the 80S ribosome mapped by directed hydroxyl radical probing. Hydroxyl Radical 86-102 eukaryotic translation initiation factor 5B Homo sapiens 41-46 17561102-6 2007 When IR was performed in the presence of N(2)O, obviating H(2)O(2) production and increasing hydroxyl radical ((*)OH) production, the Yap1 response was lost, indicating that Yap1 was unable to respond to (*)OH or (*)OH-induced damage. Hydroxyl Radical 93-109 DNA-binding transcription factor YAP1 Saccharomyces cerevisiae S288C 174-178 17588516-3 2007 Here we show by directed hydroxyl radical probing that the human eIF3 subunit eIF3j binds to the aminoacyl (A) site and mRNA entry channel of the 40S subunit, placing eIF3j directly in the ribosomal decoding center. Hydroxyl Radical 25-41 eukaryotic translation initiation factor 3 subunit A Homo sapiens 65-69 17530779-5 2007 Analysis of the selected molecules followed by hydroxyl radical footprinting experiments and yeast one-hybrid assays indicated that HAT3.1 shows a preference for the sequence T(A/G)(A/C)ACCA, different from those bound by other homeodomains. Hydroxyl Radical 47-63 homeobox-leucine zipper protein 3 Arabidopsis thaliana 132-136 17588516-3 2007 Here we show by directed hydroxyl radical probing that the human eIF3 subunit eIF3j binds to the aminoacyl (A) site and mRNA entry channel of the 40S subunit, placing eIF3j directly in the ribosomal decoding center. Hydroxyl Radical 25-41 eukaryotic translation initiation factor 3 subunit J Homo sapiens 78-83 17588516-3 2007 Here we show by directed hydroxyl radical probing that the human eIF3 subunit eIF3j binds to the aminoacyl (A) site and mRNA entry channel of the 40S subunit, placing eIF3j directly in the ribosomal decoding center. Hydroxyl Radical 25-41 eukaryotic translation initiation factor 3 subunit J Homo sapiens 167-172 17428668-5 2007 All kinds of the compounds (HCS, LCS, HCSS, LCSS, HSACS, LSACS, HSACSS, LSACSS) showed stronger scavenging activity on hydroxyl radical than ascorbic acid (Vc). Hydroxyl Radical 119-135 LCS1 Homo sapiens 33-36 17187958-0 2007 Cytochrome P450 destruction by benzene metabolites 1,4-benzoquinone and 1,4-hydroquinone and the formation of hydroxyl radicals in minipig liver microsomes. Hydroxyl Radical 110-127 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 17420775-14 2007 We show here that TRPV3 is activated by a number of monoterpenes and that a secondary hydroxyl-group is a structural requirement. Hydroxyl Radical 86-94 transient receptor potential cation channel subfamily V member 3 Homo sapiens 18-23 17485090-0 2007 Sialic acid is an essential moiety of mucin as a hydroxyl radical scavenger. Hydroxyl Radical 49-65 mucin 1, cell surface associated Bos taurus 38-43 17485090-2 2007 The function of mucin as a hydroxyl radical (.OH) scavenger was characterized using bovine submaxillary gland mucin (BSM). Hydroxyl Radical 27-43 mucin 1, cell surface associated Bos taurus 16-21 17425297-6 2007 X-ray crystal structures of nNOS with inhibitors 3 and 5 bound verified that the N-hydroxyl group had, indeed, displaced the structural water molecule and provided a direct interaction with the heme propionate moiety (Figures 5 and 6). Hydroxyl Radical 83-91 nitric oxide synthase 1 Homo sapiens 28-32 17539533-6 2007 We demonstrate that four factors are sufficient to account for the variability of PCB concentrations in air over a diel period; temperature, local atmospheric stability, hydroxyl radical concentration, and source type. Hydroxyl Radical 170-186 pyruvate carboxylase Homo sapiens 82-85 17291459-0 2007 Effects of hydroxyl radical scavenging on cisplatin-induced p53 activation, tubular cell apoptosis and nephrotoxicity. Hydroxyl Radical 11-27 transformation related protein 53, pseudogene Mus musculus 60-63 17291459-13 2007 Collectively, this study has suggested a role of oxidative stress, particularly hydroxyl radicals, in cisplatin-induced p53 activation, tubular cell apoptosis and nephrotoxicity. Hydroxyl Radical 80-97 transformation related protein 53, pseudogene Mus musculus 120-123 17320757-0 2007 Reduction of hexavalent chromium by human cytochrome b5: generation of hydroxyl radical and superoxide. Hydroxyl Radical 71-87 cytochrome b5 type A Homo sapiens 42-55 17224279-5 2007 Chemical and functional characteristics analysis of the recombinant human MT2A exhibited intact metal binding ability, hydroxyl radical scavenging ability and significant protective role against DNA damage caused by UVC radiation. Hydroxyl Radical 119-135 metallothionein 2A Homo sapiens 74-78 17331551-4 2007 Structure-activity relationships demonstrated the requirement for both an alpha-C2 bridge and a free hydroxyl at the C-11 position as pharmacophoric requirements for this activity. Hydroxyl Radical 101-109 RNA polymerase III subunit K Homo sapiens 117-121 17244611-6 2007 In the presence of hydrogen peroxide, however, IscA completely loses its iron binding activity, whereas CyaY becomes a competent iron-binding protein and attenuates the iron-mediated production of hydroxyl free radicals. Hydroxyl Radical 197-205 frataxin Homo sapiens 104-108 17320766-4 2007 Oxy- and methemoglobin, free heme, and Fenton reaction-induced hydroxyl radicals induced a dose-dependent up-regulation of alpha(1)-microglobulin on both mRNA and protein levels in hepatoma cells and an increased secretion of alpha(1)-microglobulin. Hydroxyl Radical 63-80 hemoglobin subunit gamma 2 Homo sapiens 9-22 17254600-5 2007 Hydroxyl radical footprinting and dimethylsulphate (DMS) modifications show that SRP68/72 brings the lower part of helices 6 and 8 closer. Hydroxyl Radical 0-16 signal recognition particle 68 Homo sapiens 81-86 17263456-4 2007 Collagen and thrombin, platelet aggregatory agents that can cause the release of AA by platelets, enhanced baicalein-induced hydroxyl radical formation, whereas ADP and U44619 showed no significant effects. Hydroxyl Radical 125-141 coagulation factor II, thrombin Homo sapiens 13-21 17365288-6 2007 The products obtained by the solar radiation of PAH after extraction to DCM were mainly ketone and hydroxyl derivatives. Hydroxyl Radical 99-107 phenylalanine hydroxylase Homo sapiens 48-51 17263456-5 2007 Quinacrine and 5,8,11,14-eicosatetraenoic trifluoromethyl ketone, both PLA2 inhibitors, significantly attenuated baicalein-induced hydroxyl radical formation. Hydroxyl Radical 131-147 phospholipase A2 group IB Homo sapiens 71-75 17105867-9 2007 Docking of steroids within the crystal structure of the ligand-binding domain of MR, together with trans-activation studies, revealed that the contacts between the 17beta-hydroxyl group of androgens and the Asn770, Cys942, and Thr945 residues of the ligand-binding cavity stabilize ligand binding complexes but are not strong enough to keep the receptor in its active state. Hydroxyl Radical 171-179 nuclear receptor subfamily 3 group C member 2 Homo sapiens 81-83 16870332-6 2007 The dissolved oxygen competed against hydroxyl radical to react with ortho-parachlorohydroxyphenyl radical (ClHP) producing ortho-parachlorophenolperoxyl radical (ClPP) and impeding the generation of 4-chlorocatechol. Hydroxyl Radical 38-54 caseinolytic mitochondrial matrix peptidase proteolytic subunit Homo sapiens 163-167 17356309-0 2007 Hydroxyl radical mediates the augmented angiotensin II responses in thoracic aorta of spontaneously hypertensive rats. Hydroxyl Radical 0-16 angiotensinogen Rattus norvegicus 40-54 17356309-1 2007 AIM: To investigate the role of hydroxyl radical in augmented angiotensin II (Ang II) responses in the thoracic aorta of spontaneously hypertensive rats (SHR). Hydroxyl Radical 32-48 angiotensinogen Rattus norvegicus 62-76 17356309-1 2007 AIM: To investigate the role of hydroxyl radical in augmented angiotensin II (Ang II) responses in the thoracic aorta of spontaneously hypertensive rats (SHR). Hydroxyl Radical 32-48 angiotensinogen Rattus norvegicus 78-84 17356309-8 2007 CONCLUSION: From the results we infer that hydroxyl radical stress augments Ang II responses in the thoracic aorta of SHR and, by attenuating these enhanced vascular responses, edaravone could serve as an adjuvant antioxidant therapy for the vascular complications of hypertension. Hydroxyl Radical 43-51 angiotensinogen Rattus norvegicus 76-82 16888736-1 2006 Combined kinetic (electrochemical) and thermodynamic (calorimetric) investigations were performed for an unbound (intact native-like) cytochrome c (CytC) freely diffusing to and from gold electrodes modified by hydroxyl-terminated self-assembled monolayer films (SAMs), under a unique broad range of experimental conditions. Hydroxyl Radical 211-219 cytochrome c, somatic Homo sapiens 134-146 16699069-7 2006 MMP-2 transcription and translation were inhibited by perfusion with 1.0 mM hydroxyl radical scavenger N-(-2-mercaptopropionyl)-glycine. Hydroxyl Radical 76-92 matrix metallopeptidase 2 Mus musculus 0-5 16857676-3 2006 Here we analyzed RNA structural requirements for association of hPrp31 with U4 snRNP in vitro by hydroxyl radical footprinting. Hydroxyl Radical 97-113 pre-mRNA processing factor 31 Homo sapiens 64-70 17447855-2 2007 For this purpose, the effect of heating on the activity of xanthine oxidase (XOD) in tumor cells upon their photosensitization with HPD was examined; this enzyme is participated in purine catabolism and has the ability to generate O2-*, a precursor of H2O2 and very cytotoxic hydroxyl radical. Hydroxyl Radical 276-292 xanthine dehydrogenase Mus musculus 59-75 17447855-2 2007 For this purpose, the effect of heating on the activity of xanthine oxidase (XOD) in tumor cells upon their photosensitization with HPD was examined; this enzyme is participated in purine catabolism and has the ability to generate O2-*, a precursor of H2O2 and very cytotoxic hydroxyl radical. Hydroxyl Radical 276-292 xanthine dehydrogenase Mus musculus 77-80 17131291-5 2006 The results showed that UPF1 and UPF15 are powerful hydroxyl radical scavengers and their dimerisation process velocity is higher than that of glutathione. Hydroxyl Radical 52-60 UPF1 RNA helicase and ATPase Homo sapiens 24-28 16945391-1 2006 The role of hydroxyl radical (.OH) damaged human serum albumin (HSA) in type 1 diabetes has been investigated in the present study. Hydroxyl Radical 12-28 albumin Homo sapiens 49-62 16860827-8 2006 Quantitative determination of PAF and hydroxyl-PAF analogue (expressed as PAF-like activity) showed a statistically significant increase in the ratio of plasma hydroxyl-PAF analogue levels to plasma PAF levels in volunteers with periodontitis. Hydroxyl Radical 38-46 PCNA clamp associated factor Homo sapiens 47-50 16860827-8 2006 Quantitative determination of PAF and hydroxyl-PAF analogue (expressed as PAF-like activity) showed a statistically significant increase in the ratio of plasma hydroxyl-PAF analogue levels to plasma PAF levels in volunteers with periodontitis. Hydroxyl Radical 38-46 PCNA clamp associated factor Homo sapiens 47-50 16860827-8 2006 Quantitative determination of PAF and hydroxyl-PAF analogue (expressed as PAF-like activity) showed a statistically significant increase in the ratio of plasma hydroxyl-PAF analogue levels to plasma PAF levels in volunteers with periodontitis. Hydroxyl Radical 38-46 PCNA clamp associated factor Homo sapiens 47-50 16860827-8 2006 Quantitative determination of PAF and hydroxyl-PAF analogue (expressed as PAF-like activity) showed a statistically significant increase in the ratio of plasma hydroxyl-PAF analogue levels to plasma PAF levels in volunteers with periodontitis. Hydroxyl Radical 38-46 PCNA clamp associated factor Homo sapiens 47-50 16888736-1 2006 Combined kinetic (electrochemical) and thermodynamic (calorimetric) investigations were performed for an unbound (intact native-like) cytochrome c (CytC) freely diffusing to and from gold electrodes modified by hydroxyl-terminated self-assembled monolayer films (SAMs), under a unique broad range of experimental conditions. Hydroxyl Radical 211-219 cytochrome c, somatic Homo sapiens 148-152 16895803-5 2006 Thus, while superoxide dismutase (SOD) only reduced the toxicity, catalase, in particular in the presence of SOD, provided complete protection of insulin-producing cells against the cytotoxic action of alloxan and dialuric acid due to H(2)O(2) destruction and the prevention of hydroxyl radical ((*)OH) formation, indicating that it is the hydroxyl radical ((*)OH) which is the ROS ultimately responsible for cell death. Hydroxyl Radical 278-294 catalase Homo sapiens 66-74 17060027-0 2006 Hydroxyl radical modification of human serum albumin generated cross reactive antibodies. Hydroxyl Radical 0-16 albumin Oryctolagus cuniculus 39-52 17060027-1 2006 Hydroxyl radical-mediated in vitro modification of human serum albumin (HSA) showed 59.2% hyperchromicity at lambdamax, 30% loss of alpha helical structure and 71.4% loss of tryptophan fluorescence. Hydroxyl Radical 0-16 albumin Oryctolagus cuniculus 57-70 16895803-5 2006 Thus, while superoxide dismutase (SOD) only reduced the toxicity, catalase, in particular in the presence of SOD, provided complete protection of insulin-producing cells against the cytotoxic action of alloxan and dialuric acid due to H(2)O(2) destruction and the prevention of hydroxyl radical ((*)OH) formation, indicating that it is the hydroxyl radical ((*)OH) which is the ROS ultimately responsible for cell death. Hydroxyl Radical 278-294 insulin Homo sapiens 146-153 16895803-5 2006 Thus, while superoxide dismutase (SOD) only reduced the toxicity, catalase, in particular in the presence of SOD, provided complete protection of insulin-producing cells against the cytotoxic action of alloxan and dialuric acid due to H(2)O(2) destruction and the prevention of hydroxyl radical ((*)OH) formation, indicating that it is the hydroxyl radical ((*)OH) which is the ROS ultimately responsible for cell death. Hydroxyl Radical 340-356 catalase Homo sapiens 66-74 16895803-5 2006 Thus, while superoxide dismutase (SOD) only reduced the toxicity, catalase, in particular in the presence of SOD, provided complete protection of insulin-producing cells against the cytotoxic action of alloxan and dialuric acid due to H(2)O(2) destruction and the prevention of hydroxyl radical ((*)OH) formation, indicating that it is the hydroxyl radical ((*)OH) which is the ROS ultimately responsible for cell death. Hydroxyl Radical 340-356 insulin Homo sapiens 146-153 16844151-5 2006 The rise in both the core temperature and hypothalamic glutamate and hydroxyl radicals could also be induced by direct injection of TNF-alpha (1-20 ng) into the lateral ventricle of rabbit brain. Hydroxyl Radical 69-86 tumor necrosis factor Oryctolagus cuniculus 132-141 16844151-9 2006 Both the febrile response and overproduction of both glutamate and hydroxyl radicals in the hypothalamus caused by central administration of TNF-alpha could be suppressed by baicalin. Hydroxyl Radical 67-84 tumor necrosis factor Oryctolagus cuniculus 141-150 16864566-1 2006 BACKGROUND: Superoxide dismutase (SOD) overexpression in people with Down"s syndrome negatively modifies the equilibrium SOD/glutathione peroxidase+catalase, which may ultimately lead to an increased hydroxyl radical formation. Hydroxyl Radical 200-216 superoxide dismutase 1 Homo sapiens 12-32 16864566-1 2006 BACKGROUND: Superoxide dismutase (SOD) overexpression in people with Down"s syndrome negatively modifies the equilibrium SOD/glutathione peroxidase+catalase, which may ultimately lead to an increased hydroxyl radical formation. Hydroxyl Radical 200-216 superoxide dismutase 1 Homo sapiens 34-37 16864566-1 2006 BACKGROUND: Superoxide dismutase (SOD) overexpression in people with Down"s syndrome negatively modifies the equilibrium SOD/glutathione peroxidase+catalase, which may ultimately lead to an increased hydroxyl radical formation. Hydroxyl Radical 200-216 superoxide dismutase 1 Homo sapiens 121-124 16848586-1 2006 The vibrational relaxation of hydroxyl radicals in the A (2)Sigma(+) (v=1) state has been studied using the semiclassical perturbation treatment at cryogenic temperatures. Hydroxyl Radical 30-47 immunoglobulin kappa variable 1-5 Homo sapiens 70-73 16928598-3 2006 Here we show that treatment of platelets from NIDDM patients with 300 U/mL catalase or 5 mM D-mannitol, which prevent H2O2- and hydroxyl radicals-mediated oxidative stress, respectively, increases Ca2+ extrusion after treatment with thapsigargin (TG) plus ionomycin (Iono). Hydroxyl Radical 128-145 catalase Homo sapiens 75-83 16624933-7 2006 Evidence is also presented, using Fe(2)(+)/Cu(2)(+) ions, that hydroxyl radicals generated from hydrogen peroxide through Fenton reactions could constitute candidate modulators able to directly trigger anti-IgE-elicited COX-2 expression through MAPK and NF-kappaB pathways. Hydroxyl Radical 63-80 immunoglobulin heavy constant epsilon Homo sapiens 207-210 16732619-6 2006 When the oxidation is caused by hydroxyl radical (OH*), the gamma-glutamate containing peptides (UPF1 and UPF6) exhibited two to four times higher antioxidative activity (k(II) = 4.428 and 2.152 x 10(3)/M.min, respectively). Hydroxyl Radical 32-48 UPF1 RNA helicase and ATPase Homo sapiens 97-101 16984000-3 2006 Hydrogen peroxide is catalytically converted to the aggressive hydroxyl radical in the presence of Fe(II) and Cu(I), which renders amyloidogenic proteins such as beta-amyloid and alpha-synuclein (implicated in Alzheimer"s disease (AD) and Parkinson"s disease (PD), respectively) vulnerable to self-inflicted hydroxyl radical attack. Hydroxyl Radical 63-79 synuclein alpha Homo sapiens 179-194 16984000-3 2006 Hydrogen peroxide is catalytically converted to the aggressive hydroxyl radical in the presence of Fe(II) and Cu(I), which renders amyloidogenic proteins such as beta-amyloid and alpha-synuclein (implicated in Alzheimer"s disease (AD) and Parkinson"s disease (PD), respectively) vulnerable to self-inflicted hydroxyl radical attack. Hydroxyl Radical 308-324 synuclein alpha Homo sapiens 179-194 16624933-7 2006 Evidence is also presented, using Fe(2)(+)/Cu(2)(+) ions, that hydroxyl radicals generated from hydrogen peroxide through Fenton reactions could constitute candidate modulators able to directly trigger anti-IgE-elicited COX-2 expression through MAPK and NF-kappaB pathways. Hydroxyl Radical 63-80 mitochondrially encoded cytochrome c oxidase II Homo sapiens 220-225 16545576-13 2006 From our results we infer that hydroxyl radical stress augments Ang II response in diabetic rat thoracic aorta and edaravone could be an ideal antioxidant adjuvant in the therapy of diabetic vascular complications. Hydroxyl Radical 31-39 angiotensinogen Rattus norvegicus 64-70 16485119-8 2006 Protection of rats against cisplatin-induced ARF by dimethylthiourea, a hydroxyl radical scavenger, also protected rats against the decrease in serum testosterone levels and the down-regulation of CYP2C11 and CYP3A2. Hydroxyl Radical 72-88 cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus 197-204 16878272-6 2006 CYP2E1 is also an effective generator of reactive oxygen species such as the superoxide anion radical and hydrogen peroxide, and in the presence of iron catalysts, it produces powerful oxidants such as the hydroxyl radical. Hydroxyl Radical 206-222 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 0-6 16624282-8 2006 In addition, activated MMP-9 (21 and 90 ng/ml) markedly reduced the electron spin resonance (ESR) signal intensity of hydroxyl radicals in collagen (1 mug/ml)-activated platelets. Hydroxyl Radical 118-135 matrix metallopeptidase 9 Homo sapiens 23-28 16480878-0 2006 Hydroxyl-terminated peptidomimetic inhibitors of neuronal nitric oxide synthase. Hydroxyl Radical 0-8 nitric oxide synthase 1 Homo sapiens 49-79 16546253-10 2006 These results strongly suggest that the intracellular hydroxyl radical plays a key role in the activation of TRPM2 during H(2)O(2) treatment, and TRPM2 activation mediated by hydroxyl radical is implicated in H(2)O(2)-induced cell death in the beta-cell line RIN-5F. Hydroxyl Radical 54-70 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 109-114 16546253-10 2006 These results strongly suggest that the intracellular hydroxyl radical plays a key role in the activation of TRPM2 during H(2)O(2) treatment, and TRPM2 activation mediated by hydroxyl radical is implicated in H(2)O(2)-induced cell death in the beta-cell line RIN-5F. Hydroxyl Radical 175-191 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 109-114 16546253-10 2006 These results strongly suggest that the intracellular hydroxyl radical plays a key role in the activation of TRPM2 during H(2)O(2) treatment, and TRPM2 activation mediated by hydroxyl radical is implicated in H(2)O(2)-induced cell death in the beta-cell line RIN-5F. Hydroxyl Radical 175-191 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 146-151 16546253-3 2006 In the present study, we investigated the involvement of hydroxyl radical on TRPM2 activation in TRPM2-expressing HEK293 cells and the rat beta-cell line RIN-5F. Hydroxyl Radical 57-73 transient receptor potential cation channel subfamily M member 2 Homo sapiens 97-102 16624282-9 2006 These results indicate that the antiplatelet activity of activated MMP-9 may involve the following pathways: (1) activated MMP-9 may initially induce conformational changes in platelet membranes and hydroxyl radical formation, leading to inhibition of platelet aggregation; and (2) activated MMP-9 also inhibits the Na(+)/H(+) exchanger, leading to reduced intracellular Ca(2+) mobilization, and ultimately to inhibition of platelet aggregation. Hydroxyl Radical 199-207 matrix metallopeptidase 9 Homo sapiens 67-72 16624282-9 2006 These results indicate that the antiplatelet activity of activated MMP-9 may involve the following pathways: (1) activated MMP-9 may initially induce conformational changes in platelet membranes and hydroxyl radical formation, leading to inhibition of platelet aggregation; and (2) activated MMP-9 also inhibits the Na(+)/H(+) exchanger, leading to reduced intracellular Ca(2+) mobilization, and ultimately to inhibition of platelet aggregation. Hydroxyl Radical 199-207 matrix metallopeptidase 9 Homo sapiens 123-128 16624282-9 2006 These results indicate that the antiplatelet activity of activated MMP-9 may involve the following pathways: (1) activated MMP-9 may initially induce conformational changes in platelet membranes and hydroxyl radical formation, leading to inhibition of platelet aggregation; and (2) activated MMP-9 also inhibits the Na(+)/H(+) exchanger, leading to reduced intracellular Ca(2+) mobilization, and ultimately to inhibition of platelet aggregation. Hydroxyl Radical 199-207 matrix metallopeptidase 9 Homo sapiens 123-128 16394182-4 2006 Aromatic iodination meta to the phenolic hydroxyl (on the 6"-carbon atom) converts arvanil and olvanil from TRPV1 agonists into antagonists. Hydroxyl Radical 41-49 transient receptor potential cation channel subfamily V member 1 Homo sapiens 108-113 16630378-3 2006 The major function of haptoglobin, an acute-phase plasma protein found in three different phenotypes (Hp1-1, Hp2-1 and Hp2-2), is to bind to free haemoglobin and so prevent the accumulation of reactive hydroxyl radicals and renal damage. Hydroxyl Radical 202-219 haptoglobin Homo sapiens 22-33 16546755-4 2006 In particular, metallothionein-III (MT-III) has a strong scavenging effect on hydroxyl radicals. Hydroxyl Radical 78-95 metallothionein 3 Homo sapiens 15-34 16599945-4 2006 Ceruloplasmin is largely produced by perivascular astrocytes in the central nervous system and exhibits a ferroxidase activity that inhibits iron-associated lipid peroxidation and hydroxyl radical formation; therefore, the lack of ceruloplasmin causes direct oxidative stress on astrocytes. Hydroxyl Radical 180-196 ceruloplasmin Homo sapiens 0-13 16546755-4 2006 In particular, metallothionein-III (MT-III) has a strong scavenging effect on hydroxyl radicals. Hydroxyl Radical 78-95 metallothionein 3 Homo sapiens 36-42 16406270-1 2006 The present study examined the ability of antioxidant effects of angiotensin-converting enzyme (ACE) inhibitor, imidaprilat, on the synergistic effect of bisphenol A and 1-methyl-4-phenylpyridinium ion (MPP(+))-induced hydroxyl radical (*OH) formation and dopamine (DA) efflux in extracellular fluid of rat striatum. Hydroxyl Radical 219-235 angiotensin I converting enzyme Rattus norvegicus 96-99 16481116-5 2006 The result is also compared with that obtained with another 1O2 probe 2-methyl-6-phenyl-3,7-dihydroimidazo[1,2-a]pyrazin-3-one (CLA), demonstrating that, besides 1O2, the other reactive oxygen species such as hydroxyl radical may also be involved in the reaction of saliva with H2O2. Hydroxyl Radical 209-225 selectin P ligand Homo sapiens 128-131 16253284-2 2006 The compounds, identified as FMA4, FMA5, FMA7 and FMA8 differ in the presence of hydroxyl groups located in the C-3 and/or C-4 position of a phenolic unit, which is possibly responsible for their free radicals" buffering capacity. Hydroxyl Radical 81-89 complement C3 Homo sapiens 112-115 16556974-7 2006 From these results, the configuration of a hydroxyl (OH) group about position C-2 did not influence the advanced cross-linking reaction, but the configuration of OH groups about C-3 and C-4 might be very important for formation of MRPs and their antioxidant behaviors. Hydroxyl Radical 43-51 complement C2 Homo sapiens 78-81 16386813-1 2006 The present study examined the antioxidant effects of angiotensin-converting enzyme inhibitor (ACE), imidaprilat, on para-nonylphenol and 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical (*OH) formation and dopamine (DA) efflux in extracellular fluid of rat striatum, using a microdialysis technique. Hydroxyl Radical 185-201 angiotensin I converting enzyme Rattus norvegicus 54-93 16702623-0 2006 Bismuth increases hydroxyl radical-scavenging activity of histamine H2-receptor antagonists. Hydroxyl Radical 18-34 histamine receptor H2 Homo sapiens 58-79 16475808-8 2006 S-Nitrosylated Ras (Ras-SNO) can be formed when NO serves as a radical-quenching agent, and hydroxyl radical but not (*)NO(2) or O(2)(*)(-) can further react with Ras-SNO to modulate Ras activity in vitro. Hydroxyl Radical 92-108 strawberry notch homolog 1 Homo sapiens 24-27 16475808-8 2006 S-Nitrosylated Ras (Ras-SNO) can be formed when NO serves as a radical-quenching agent, and hydroxyl radical but not (*)NO(2) or O(2)(*)(-) can further react with Ras-SNO to modulate Ras activity in vitro. Hydroxyl Radical 92-108 strawberry notch homolog 1 Homo sapiens 167-170 16111876-6 2006 In the present study, we evaluated in cell-free systems the effect of genistin and daidzin on pBR322 DNA cleavage induced by hydroxyl radicals, generated from UV photolysis of hydrogen peroxide, and their superoxide anion scavenging capacity. Hydroxyl Radical 125-142 translocator protein Homo sapiens 94-97 16150464-6 2006 In a dose-dependent manner, APS-1 was demonstrated to be free radical scavenging in superoxide and hydroxyl radical assays, inhibitory to the copper-mediated oxidation of human low density lipoprotein (LDL), and protective against hydrogen peroxide (H(2)O(2))-induced lesion to rat PC12 cell (pheochromocytoma cell line). Hydroxyl Radical 99-115 autoimmune regulator Homo sapiens 28-33 16629179-4 2006 We found that iron-dependent generation of hydroxyl radicals is likely to modulate Ca2+ signaling through RyR calcium channel activation, which, in turn, activates the MAPK/ERK pathway. Hydroxyl Radical 43-60 Eph receptor B1 Rattus norvegicus 173-176 16497162-5 2006 Hydroxyl radical footprinting and missing nucleoside experiments showed that ATH1 interacts with a 7-bp region of the strand carrying the GAC core. Hydroxyl Radical 0-16 homeobox protein ATH1 Arabidopsis thaliana 77-81 16848913-1 2006 INTRODUCTION: The cytotoxic effects of radiation therapy are mediated primarily through increased formation of hydroxyl radicals and reactive oxygen species, which can damage cells, proteins and DNA; the glutathione S-transferases (GSTs) function to protect against oxidative stress. Hydroxyl Radical 111-128 glutathione S-transferase alpha 1 Homo sapiens 232-236 17090492-10 2006 The higher photoactivity of Degussa P-25 compared to that of rutile TiO2 for the photodegradation of erioglaucine may be due to higher hydroxyl content, higher surface area, nano-size and crystallinity of the Degussa P-25. Hydroxyl Radical 135-143 tubulin polymerization promoting protein Homo sapiens 36-40 16580789-3 2006 Moreover, oxidative stress by reactive oxygen species (ROS) such as the hydroxyl radical (*OH) produced by ionizing radiation (carcinogenic) triggers p53 activation in response to the damage of DNA (followed by initiation of DNA-repair mechanisms). Hydroxyl Radical 72-88 tumor protein p53 Homo sapiens 150-153 16055159-8 2005 As a response to arginine deficiency, increased expression of the antioxidant viral GPx gene (env-fs) by upregulation of frameshifting could be protective to HIV-infected cells, as a countermeasure to the increased oxidative stress induced by arginine deficiency (because NO is a known scavenger of hydroxyl radical). Hydroxyl Radical 299-315 endogenous retrovirus group K member 20 Homo sapiens 94-97 16982647-4 2006 Directed hydroxyl radical cleavage experiments indicated that siRNA duplexes have at least four different binding sites for PKR"s dsRNA binding motifs (dsRBMs). Hydroxyl Radical 9-25 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 124-127 16224057-3 2005 We tested whether TNF-alpha accelerated iron accumulation in vascular endothelium, favoring synthesis of hydroxyl radical. Hydroxyl Radical 105-121 tumor necrosis factor Homo sapiens 18-27 16224057-8 2005 Using a salicylate trap method, we observed that only simultaneous exposure of endothelial cells to iron and TNF-alpha accelerated hydroxyl radical production. Hydroxyl Radical 131-147 tumor necrosis factor Homo sapiens 109-118 16140374-6 2005 Data indicate that Ca2+ is mobilized by hydroxyl radical but not by superoxide. Hydroxyl Radical 40-56 carbonic anhydrase II Oncorhynchus mykiss 19-22 16140374-8 2005 A role of hydroxyl radicals in the oxidative switching-on of Ca2+ signaling is discussed. Hydroxyl Radical 10-27 carbonic anhydrase II Oncorhynchus mykiss 61-64 16246910-8 2005 US11 binding protected the consensus motif from hydroxyl radical cleavage. Hydroxyl Radical 48-64 tegument protein US11 Human alphaherpesvirus 1 0-4 16140374-0 2005 Ca2+ is mobilized by hydroxyl radical but not by superoxide in RTH-149 cells: the oxidative switching-on of Ca2+ signaling. Hydroxyl Radical 21-37 carbonic anhydrase II Oncorhynchus mykiss 0-3 16211307-3 2005 Cell-free Trolox equivalent antioxidant capacity assay shows that at 1/5 dilution, ES and FE have hydroxyl radical scavenging activity equivalent to 10.65 microM and 5.74 microM of Trolox respectively. Hydroxyl Radical 98-114 angiotensin II receptor, type 1a Mus musculus 66-70 16148052-2 2005 We studied the effects of the hydroxyl radical *OH, for which there is no natural intra- or extracellular scavenger, on a Ca(2+)-activated chloride channel (CACC) that participates in Cl(-) secretion in the apical membrane of airway epithelial cells. Hydroxyl Radical 30-46 chloride channel accessory 1 Homo sapiens 157-161 16084018-5 2005 In the present study, we evaluated whether CT-1 protects cultured cortical neurons against oxidative injuries caused by the hydroxyl radical-producing agent FeSO4 and by the peroxynitrite-producing agent 3-morpholinosydnonimine (SIN-1). Hydroxyl Radical 124-140 cardiotrophin 1 Homo sapiens 43-47 16148052-7 2005 CACC activity evoked by oxidative stress was inhibited by 1,3-dimethyl-2-thiurea, an antioxidant that scavenges hydroxyl radicals, and by the reduced form of glutathione. Hydroxyl Radical 112-129 chloride channel accessory 1 Homo sapiens 0-4 16024005-5 2005 In this study, we synthesized phenyl alpha- or -beta-2-acetamido-2-deoxy-beta-D-galactopyranosides containing a sulfate group at the C-3, C-4, or C-6 hydroxyl groups and examined their inhibitory activity against recombinant GalNAc4S-6ST. Hydroxyl Radical 150-158 complement C6 Homo sapiens 146-149 15958239-5 2005 Layers of hydroxyl-terminated PEO of MW 600 formed under these low solubility conditions showed almost complete suppression (versus controls) of the Vroman effect, with 20+/-1 ng/cm2 adsorbed fibrinogen at the Vroman peak and 6.7+/-0.6 ng/cm2 at higher plasma concentration. Hydroxyl Radical 10-18 fibrinogen beta chain Homo sapiens 192-202 16105032-1 2005 BACKGROUND: Catalase is one of the important antioxidant enzymes regulating the levels of intracellular hydrogen peroxide and hydroxyl radical. Hydroxyl Radical 126-142 catalase Mus musculus 12-20 16034168-8 2005 According to results of electron spin resonance studies using 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) as a spin trapping agent, phosvitin suppressed the formation of hydroxyl radicals. Hydroxyl Radical 166-183 casein kinase 2, beta polypeptide Mus musculus 128-137 16023966-4 2005 The immunoresponse for detecting the monoclonal anti-GAD antibody was also enhanced with the reduction of the excess immobilization of biotin-GAD and the minimization of non-specific binding that resulted from the simple substitution of the spacer from a carboxylic-terminated SAM for the hydroxyl-terminated SAM. Hydroxyl Radical 289-297 glutamate decarboxylase 1 Homo sapiens 53-56 15701814-14 2005 The hydroxyl radical scavenger DMTU (100 mg.kg body wt(-1).day(-1)) prevented the activation of p38 MAPK by cisplatin both in vitro and in vivo. Hydroxyl Radical 4-20 mitogen-activated protein kinase 14 Mus musculus 96-99 15701814-16 2005 We conclude that hydroxyl radicals, either directly or indirectly, activate p38 MAPK and that p38 MAPK plays an important role in mediating cisplatin-induced acute renal injury and inflammation, perhaps through production of TNF-alpha. Hydroxyl Radical 17-34 mitogen-activated protein kinase 14 Mus musculus 76-79 15701814-16 2005 We conclude that hydroxyl radicals, either directly or indirectly, activate p38 MAPK and that p38 MAPK plays an important role in mediating cisplatin-induced acute renal injury and inflammation, perhaps through production of TNF-alpha. Hydroxyl Radical 17-34 mitogen-activated protein kinase 14 Mus musculus 76-84 15701814-16 2005 We conclude that hydroxyl radicals, either directly or indirectly, activate p38 MAPK and that p38 MAPK plays an important role in mediating cisplatin-induced acute renal injury and inflammation, perhaps through production of TNF-alpha. Hydroxyl Radical 17-34 tumor necrosis factor Mus musculus 225-234 15962356-2 2005 The analysis revealed that loss of CO(2)[M + H - 44](+) is the predominant process for compounds that exhibit a hydroxyl at C-8. Hydroxyl Radical 112-120 homeobox C8 Homo sapiens 124-127 15994130-10 2005 In summary, H2O2 produces: (1) contractions mediated by direct activation of cyclooxygenase; 2) endothelium-dependent relaxations related to activation of endothelial K+ channels and NO synthesis; 3) reversible endothelium-independent relaxations mediated by activation of smooth muscle K+ channels; and 4) irreversible endothelium-independent relaxations related to cellular damage, caused by H2O2 but not by hydroxyl radicals. Hydroxyl Radical 410-427 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 77-94 15911335-3 2005 ROS (e.g., superoxide, peroxynitrite, hydroxyl radical and hydrogen peroxide) are all potential reactants capable of initiating DNA single strand breakage, with subsequent activation of the nuclear enzyme poly(ADP-ribose) synthetase (PARS), leading to eventual severe energy depletion of the cells, and necrotic-type cell death. Hydroxyl Radical 38-54 poly(ADP-ribose) polymerase 1 Homo sapiens 205-232 15882436-4 2005 In addition, anti-oxidants such as hydroxyl-radical excluders and capturers of superoxide and inhibitors of superoxide production effectively reduced the size of the apoptotic fraction in MT-2 cells cultured with chrysotile-A. Hydroxyl Radical 35-51 metallothionein 2A Homo sapiens 188-192 15840492-1 2005 Photochemically generated hydroxyl radicals were used to map solvent-exposed regions in the C14S mutant of the protein Sml1p, a regulator of the ribonuclease reductase enzyme Rnr1p in Saccharomyces cerevisiae. Hydroxyl Radical 26-43 ribonucleotide reductase inhibiting protein SML1 Saccharomyces cerevisiae S288C 119-124 15840492-1 2005 Photochemically generated hydroxyl radicals were used to map solvent-exposed regions in the C14S mutant of the protein Sml1p, a regulator of the ribonuclease reductase enzyme Rnr1p in Saccharomyces cerevisiae. Hydroxyl Radical 26-43 ribonucleotide-diphosphate reductase subunit RNR1 Saccharomyces cerevisiae S288C 175-180 15840492-2 2005 By using high-performance mass spectrometry to characterize the oxidized peptides created by the hydroxyl radical reactions, amino acid solvent-accessibility data for native and denatured C14S Sml1p that revealed a solvent-excluding tertiary structure in the native state were obtained. Hydroxyl Radical 97-113 ribonucleotide reductase inhibiting protein SML1 Saccharomyces cerevisiae S288C 193-198 15689384-6 2005 The initial product of the MPO-H2O2-chloride system is hypochlorous acid, and subsequent formation of chlorine, chloramines, hydroxyl radicals, singlet oxygen, and ozone has been proposed. Hydroxyl Radical 125-142 myeloperoxidase Homo sapiens 27-30 15799708-6 2005 Here we focus on a hydroxyl-substituted analog (hydroxy-PP) of the known Src-family kinase inhibitor PP2 because it induced cell-specific morphological features distinct from all known kinase inhibitors in the collection. Hydroxyl Radical 19-27 neuropeptide Y receptor Y6 (pseudogene) Homo sapiens 101-104 15795783-1 2005 [small beta]-Hydroxy acids were readily converted into [small beta]-tosyloxy acids (hydroxyl group activation) in moderate to excellent yields via the O,O-dianions generated by treatment with methyllithium and thus make it possible to prepare anti[small alpha],[small beta]-disubstituted [small beta]-lactones directly from the syn aldols. Hydroxyl Radical 84-92 synemin Homo sapiens 328-331 15694845-8 2005 Both the hydrogen peroxide- and peroxynitrite-induced increases in tetrahydrobiopterin content and findings suggest that not only hydrogen peroxide but also the hydroxyl radical and peroxynitrite stimulates tetrahydrobiopterin synthesis through GTP-cyclohydrolase I expression, and that the hydroxyl radical plays a central role in the stimulation of tetrahydrobiopterin synthesis. Hydroxyl Radical 161-177 GTP cyclohydrolase 1 Homo sapiens 245-265 15749016-2 2005 PNK acts as a 5"-kinase/3"-phosphatase to create 5"-phosphate/3"-hydroxyl termini, which are a necessary prerequisite for ligation during repair. Hydroxyl Radical 65-73 polynucleotide kinase 3'-phosphatase Homo sapiens 0-3 15827333-4 2005 We have synthesized two hydroxyl derivatives of NSC 95397, monohydroxyl-NSC 95397 and dihydroxyl-NSC 95397, which both have enhanced activity for inhibiting Cdc25s. Hydroxyl Radical 24-32 cell division cycle 25C Homo sapiens 157-162 15368542-2 2005 Using electron spin resonance (ESR) spectroscopy, we showed that activation of Fas receptor by its ligand (FasL) in macrophages resulted in a rapid and transient production of hydrogen peroxide (H2O2) and hydroxyl radicals (*OH). Hydroxyl Radical 205-222 Fas ligand Homo sapiens 107-111 15755449-11 2005 Also, as for HuHF, minimal hydroxyl radical is produced during the oxidative deposition of iron in MtF using O(2) as the oxidant. Hydroxyl Radical 27-43 ferritin mitochondrial Homo sapiens 99-102 16851472-1 2005 Molecular dynamics simulations of hydroxyl radical in water are carried out by use of a classical simple point charge extended (SPC/E) water model and a similar point charge model for hydroxyl radical. Hydroxyl Radical 34-50 proline rich protein gene cluster Homo sapiens 128-131 15694258-3 2005 Effect of h-PRP on hydroxyl radical (*OH) generation in a Fenton-like reaction was monitored, employing a sensitive salicylate hydroxylation procedure. Hydroxyl Radical 19-35 proline rich protein HaeIII subfamily 1 Mus musculus 12-15 15672144-0 2005 Calmodulin methionine residues are targets for one-electron oxidation by hydroxyl radicals: formation of S[therefore]N three-electron bonded radical complexes. Hydroxyl Radical 73-90 calmodulin 1 Homo sapiens 0-10 15776560-0 2005 In vitro evaluation of the anti-estrogenic activity of hydroxyl substituted diphenylnaphthyl alkene ligands for the estrogen receptor. Hydroxyl Radical 55-63 estrogen receptor 1 Homo sapiens 116-133 15624917-3 2005 The common 1,2-anti-2,3-syn stereotriad found in each of three subunits, aldehyde 9 (C(1)-C(5)), ester 40 (C(9)-C(16)), and aldehyde 13 (C(17)-C(24)), was established via a boron-mediated aldol reaction of ethyl ketone 15 and formaldehyde, followed by hydroxyl-directed reduction to give 1,3-diol 14. Hydroxyl Radical 252-260 synemin Homo sapiens 24-27 15694772-0 2005 Hydroxyl radical probe of the calmodulin-melittin complex interface by electrospray ionization mass spectrometry. Hydroxyl Radical 0-16 calmodulin 1 Homo sapiens 30-40 15694772-1 2005 The calcium-dependent interaction of calmodulin and melittin is studied through the application of a radical probe approach in which solutions of the protein and peptide and protein alone are subjected to high fluxes of hydroxyl and other oxygen radicals on millisecond timescales. Hydroxyl Radical 220-228 calmodulin 1 Homo sapiens 37-47 15698578-7 2005 Among salicylic acid-related drugs, salsalate, but not aspirin and ethenzamide, inactivated CK, indicating the phenolic hydroxyl group is oxidized by LPO-H2O2. Hydroxyl Radical 120-128 lactoperoxidase Oryctolagus cuniculus 150-153 15476709-5 2004 Firstly the fluorine serves as a non-nucleophilic isostere for the acceptor hydroxyl in studies with glycosyl transferases GnT-I and GnT-II (7 and 9, respectively). Hydroxyl Radical 76-84 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Homo sapiens 123-128 15773552-5 2005 A partial inhibition of HOX-1 induction occurred in the presence of non-polar hydroxyl radical scavengers, dimethyl sulfoxide and dimetylthiourea. Hydroxyl Radical 78-94 heme oxygenase 1 Homo sapiens 24-29 16438801-1 2005 Haptoglobin (Hp) prevents the hemoglobin driven generation of hydroxyl radicals and lipid peroxides. Hydroxyl Radical 62-79 haptoglobin Homo sapiens 0-11 15465643-3 2004 Addition of catalase protected DNA from the curcumin-dependent injuries, indicating that hydroxyl radical may participate in the DNA damage. Hydroxyl Radical 89-105 catalase Homo sapiens 12-20 15493986-10 2004 Generation of ceramide was blocked by desferrioxamine, suggesting that hydroxyl radicals are important for the activation of ASM. Hydroxyl Radical 71-88 sphingomyelin phosphodiesterase 1, acid lysosomal Mus musculus 125-128 15912211-3 2005 In this study we checked whether combined action of two unfolding factors, SDS and peroxynitrite or radiation (hydroxyl radicals), increases the peroxidase-like activity of cytochrome c more than any single treatment alone. Hydroxyl Radical 111-128 cytochrome c, somatic Homo sapiens 173-185 15912211-8 2005 The overall effect observed is that the peroxidase-like activity of SDS-modified cytochrome c decreases with an increase of the concentration of the oxidizing species (peroxynitrite or radiolytically generated hydroxyl radicals). Hydroxyl Radical 210-227 cytochrome c, somatic Homo sapiens 81-93 15569593-4 2005 We utilized the Fenton reaction for free hydroxyl radical (HO*) generation in presence of human recombinant insulin measuring chemical changes on its molecular structure. Hydroxyl Radical 41-57 insulin Homo sapiens 108-115 15569593-8 2005 In conclusion, the radical hydroxyl in vitro is able to induce molecular modifications on insulin. Hydroxyl Radical 27-35 insulin Homo sapiens 90-97 15489221-10 2004 In contrast, preincubation of cells with the hydroxyl radical scavenger, N-acetylcysteine, significantly attenuated the doxorubicin-mediated phosphorylation and accumulation of p53, p53-DNA binding, and the phosphorylation of H2AX, Nbs1, SMC1, Chk1, and Chk2, suggesting that hydroxyl radicals contribute to the doxorubicin-induced activation of ATM-dependent pathways. Hydroxyl Radical 45-61 tumor protein p53 Homo sapiens 177-180 15489221-10 2004 In contrast, preincubation of cells with the hydroxyl radical scavenger, N-acetylcysteine, significantly attenuated the doxorubicin-mediated phosphorylation and accumulation of p53, p53-DNA binding, and the phosphorylation of H2AX, Nbs1, SMC1, Chk1, and Chk2, suggesting that hydroxyl radicals contribute to the doxorubicin-induced activation of ATM-dependent pathways. Hydroxyl Radical 45-61 tumor protein p53 Homo sapiens 182-185 15489221-10 2004 In contrast, preincubation of cells with the hydroxyl radical scavenger, N-acetylcysteine, significantly attenuated the doxorubicin-mediated phosphorylation and accumulation of p53, p53-DNA binding, and the phosphorylation of H2AX, Nbs1, SMC1, Chk1, and Chk2, suggesting that hydroxyl radicals contribute to the doxorubicin-induced activation of ATM-dependent pathways. Hydroxyl Radical 45-61 H2A.X variant histone Homo sapiens 226-230 15489221-10 2004 In contrast, preincubation of cells with the hydroxyl radical scavenger, N-acetylcysteine, significantly attenuated the doxorubicin-mediated phosphorylation and accumulation of p53, p53-DNA binding, and the phosphorylation of H2AX, Nbs1, SMC1, Chk1, and Chk2, suggesting that hydroxyl radicals contribute to the doxorubicin-induced activation of ATM-dependent pathways. Hydroxyl Radical 45-61 nibrin Homo sapiens 232-236 15489221-10 2004 In contrast, preincubation of cells with the hydroxyl radical scavenger, N-acetylcysteine, significantly attenuated the doxorubicin-mediated phosphorylation and accumulation of p53, p53-DNA binding, and the phosphorylation of H2AX, Nbs1, SMC1, Chk1, and Chk2, suggesting that hydroxyl radicals contribute to the doxorubicin-induced activation of ATM-dependent pathways. Hydroxyl Radical 45-61 structural maintenance of chromosomes 1A Homo sapiens 238-242 15489221-10 2004 In contrast, preincubation of cells with the hydroxyl radical scavenger, N-acetylcysteine, significantly attenuated the doxorubicin-mediated phosphorylation and accumulation of p53, p53-DNA binding, and the phosphorylation of H2AX, Nbs1, SMC1, Chk1, and Chk2, suggesting that hydroxyl radicals contribute to the doxorubicin-induced activation of ATM-dependent pathways. Hydroxyl Radical 45-61 checkpoint kinase 1 Homo sapiens 244-248 15489221-10 2004 In contrast, preincubation of cells with the hydroxyl radical scavenger, N-acetylcysteine, significantly attenuated the doxorubicin-mediated phosphorylation and accumulation of p53, p53-DNA binding, and the phosphorylation of H2AX, Nbs1, SMC1, Chk1, and Chk2, suggesting that hydroxyl radicals contribute to the doxorubicin-induced activation of ATM-dependent pathways. Hydroxyl Radical 45-61 checkpoint kinase 2 Homo sapiens 254-258 15489221-10 2004 In contrast, preincubation of cells with the hydroxyl radical scavenger, N-acetylcysteine, significantly attenuated the doxorubicin-mediated phosphorylation and accumulation of p53, p53-DNA binding, and the phosphorylation of H2AX, Nbs1, SMC1, Chk1, and Chk2, suggesting that hydroxyl radicals contribute to the doxorubicin-induced activation of ATM-dependent pathways. Hydroxyl Radical 45-61 ATM serine/threonine kinase Homo sapiens 346-349 15489015-2 2004 We designed and synthesized a novel non-toxic glutathione analogue, named UPF1, which possessed 60-fold higher hydroxyl radical scavenger efficiency in vitro, compared with glutathione itself, and investigated the effects of UPF1 on a four-vessel occlusion model of rats. Hydroxyl Radical 111-127 UPF1, RNA helicase and ATPase Rattus norvegicus 74-78 15476709-5 2004 Firstly the fluorine serves as a non-nucleophilic isostere for the acceptor hydroxyl in studies with glycosyl transferases GnT-I and GnT-II (7 and 9, respectively). Hydroxyl Radical 76-84 alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Homo sapiens 133-139 15450373-1 2004 Hydrogen peroxide and hydroxyl-free radicals determine a diffuse aggregation of porcine fumarase and a loss of its enzymatic activity. Hydroxyl Radical 22-30 fumarate hydratase Homo sapiens 88-96 15169673-9 2004 NO induction of IL-8 mRNA was significantly reduced by inhibitors of extracellular regulated kinase and protein kinase C. IL-8 induction by NO was also reduced by hydroxyl radical scavengers such as dimethyl sulfoxide and dimethylthiourea, indicating the involvement of hydroxyl radicals in the induction process. Hydroxyl Radical 163-179 C-X-C motif chemokine ligand 8 Homo sapiens 16-20 15169673-9 2004 NO induction of IL-8 mRNA was significantly reduced by inhibitors of extracellular regulated kinase and protein kinase C. IL-8 induction by NO was also reduced by hydroxyl radical scavengers such as dimethyl sulfoxide and dimethylthiourea, indicating the involvement of hydroxyl radicals in the induction process. Hydroxyl Radical 163-179 C-X-C motif chemokine ligand 8 Homo sapiens 122-126 15169673-9 2004 NO induction of IL-8 mRNA was significantly reduced by inhibitors of extracellular regulated kinase and protein kinase C. IL-8 induction by NO was also reduced by hydroxyl radical scavengers such as dimethyl sulfoxide and dimethylthiourea, indicating the involvement of hydroxyl radicals in the induction process. Hydroxyl Radical 270-287 C-X-C motif chemokine ligand 8 Homo sapiens 16-20 15169673-9 2004 NO induction of IL-8 mRNA was significantly reduced by inhibitors of extracellular regulated kinase and protein kinase C. IL-8 induction by NO was also reduced by hydroxyl radical scavengers such as dimethyl sulfoxide and dimethylthiourea, indicating the involvement of hydroxyl radicals in the induction process. Hydroxyl Radical 270-287 C-X-C motif chemokine ligand 8 Homo sapiens 122-126 15378229-1 2004 The effect of catechol-O-methyltransferase (COMT) deficiency on methamphetamine-induced hydroxyl radical production in the brain was assessed by the salicylate trapping method. Hydroxyl Radical 88-104 catechol-O-methyltransferase Mus musculus 14-42 15378229-1 2004 The effect of catechol-O-methyltransferase (COMT) deficiency on methamphetamine-induced hydroxyl radical production in the brain was assessed by the salicylate trapping method. Hydroxyl Radical 88-104 catechol-O-methyltransferase Mus musculus 44-48 15612529-8 2004 The increase in hydroxyl radical concentration was accompanied by an increase in antioxidant enzyme expression (SOD1 and SOD2), and an increase in nitrotyrosine expression was also observed, reflecting the increased production of NO and oxygen radicals. Hydroxyl Radical 16-32 superoxide dismutase 1 Homo sapiens 112-116 15612529-8 2004 The increase in hydroxyl radical concentration was accompanied by an increase in antioxidant enzyme expression (SOD1 and SOD2), and an increase in nitrotyrosine expression was also observed, reflecting the increased production of NO and oxygen radicals. Hydroxyl Radical 16-32 superoxide dismutase 2 Homo sapiens 121-125 15451060-0 2004 Hydroxyl radical oxidation of cytochrome c by aerobic radiolysis. Hydroxyl Radical 0-16 cytochrome c, somatic Homo sapiens 30-42 15313218-5 2004 HMW-MRPs exhibited stronger (p<0.05) antioxidant activity to scavenge hydroxyl and DPPH radicals, and a greater (p<0.05) protective effect against both Fe(2+)- and Cu(2+)-induced cytotoxicity in Caco-2 cells than corresponding LMW-MRPs. Hydroxyl Radical 73-81 cilia and flagella associated protein 97 Homo sapiens 0-3 15621715-6 2004 The DOPA/Cu(2+)-induced inactivation of PON1 was prevented by catalase, but not hydroxyl radical scavengers, consistent with Cu(2+)-catalyzed oxidation. Hydroxyl Radical 80-96 paraoxonase 1 Homo sapiens 40-44 15271890-0 2004 Cleavage of human transferrin by Porphyromonas gingivalis gingipains promotes growth and formation of hydroxyl radicals. Hydroxyl Radical 102-119 transferrin Homo sapiens 18-29 16026010-2 2004 A lack of cytotoxicity of the iron(III) porphyrin-loaded liposomes and an efficient generation of a toxic hydroxyl radical (OH*) from a superoxide anion radical (O2-*) through the iron(III)-catalyzed dismutation and the Fenton-like reaction allow for a targeted necrosis of tumor cells where the concentration of O2-* is locally increased as a result of the reduced activity of superoxide dismutase and catalase in these cells. Hydroxyl Radical 106-122 catalase Homo sapiens 403-411 15291585-2 2004 The gas phase reaction between formic acid and hydroxyl radical has been investigated with high level quantum mechanical calculations using DFT-B3LYP, MP2, CASSCF, QCISD, and CCSD(T) theoretical approaches in connection with the 6-311+G(2df,2p) and aug-cc-pVTZ basis sets. Hydroxyl Radical 47-63 tryptase pseudogene 1 Homo sapiens 151-154 15462181-4 2004 Addition of superoxide dismutase (SOD) to the reaction mixture partially reduced the intensity of signals confirming the production of superoxide radical as well as hydroxyl radicals. Hydroxyl Radical 165-182 superoxide dismutase [Mn], mitochondrial Cucumis sativus 12-32 15462181-4 2004 Addition of superoxide dismutase (SOD) to the reaction mixture partially reduced the intensity of signals confirming the production of superoxide radical as well as hydroxyl radicals. Hydroxyl Radical 165-182 superoxide dismutase [Mn], mitochondrial Cucumis sativus 34-37 15271890-2 2004 The aims of this study were to investigate the degradation of human transferrin by gingipain cysteine proteinases of P. gingivalis and to demonstrate the production of toxic hydroxyl radicals (HO*) catalyzed by the iron-containing transferrin fragments generated or by release of iron itself. Hydroxyl Radical 174-191 transferrin Homo sapiens 68-79 15271890-2 2004 The aims of this study were to investigate the degradation of human transferrin by gingipain cysteine proteinases of P. gingivalis and to demonstrate the production of toxic hydroxyl radicals (HO*) catalyzed by the iron-containing transferrin fragments generated or by release of iron itself. Hydroxyl Radical 174-191 transferrin Homo sapiens 231-242 15515950-10 2004 The affinity of edge hydroxyl to Cd2+ would lead to the difference of Cd2+ desorption rate and amounts. Hydroxyl Radical 21-29 CD2 molecule Homo sapiens 33-36 15273299-2 2004 The mechanisms of reduction of the orthoquinone cofactor (PQQ) of MDH and sGDH involve concerted base-catalyzed proton abstraction from the hydroxyl moiety of methanol or from the 1-hydroxyl of glucose, and hydride equivalent transfer from the substrate to the quinone carbonyl carbon C5 of PQQ. Hydroxyl Radical 140-148 NADH:ubiquinone oxidoreductase subunit B5 Homo sapiens 74-78 15273299-2 2004 The mechanisms of reduction of the orthoquinone cofactor (PQQ) of MDH and sGDH involve concerted base-catalyzed proton abstraction from the hydroxyl moiety of methanol or from the 1-hydroxyl of glucose, and hydride equivalent transfer from the substrate to the quinone carbonyl carbon C5 of PQQ. Hydroxyl Radical 182-190 NADH:ubiquinone oxidoreductase subunit B5 Homo sapiens 74-78 15273299-7 2004 The general-base-catalyzed hydroxyl proton abstraction from substrate concerted with hydride transfer to the C5 of PQQ is assisted by hydrogen-bonding to the C5=O by Wat1 and Arg 324 in MDH and by Wat89 and Arg 228 in sGDH. Hydroxyl Radical 27-35 MTOR associated protein, LST8 homolog Homo sapiens 166-170 15273299-7 2004 The general-base-catalyzed hydroxyl proton abstraction from substrate concerted with hydride transfer to the C5 of PQQ is assisted by hydrogen-bonding to the C5=O by Wat1 and Arg 324 in MDH and by Wat89 and Arg 228 in sGDH. Hydroxyl Radical 27-35 malate dehydrogenase 2 Homo sapiens 186-189 15273299-7 2004 The general-base-catalyzed hydroxyl proton abstraction from substrate concerted with hydride transfer to the C5 of PQQ is assisted by hydrogen-bonding to the C5=O by Wat1 and Arg 324 in MDH and by Wat89 and Arg 228 in sGDH. Hydroxyl Radical 27-35 NADH:ubiquinone oxidoreductase subunit B5 Homo sapiens 218-222 15178682-1 2004 Catalase plays a major role in cellular antioxidant defense by decomposing hydrogen peroxide, thereby preventing the generation of hydroxyl radical by the Fenton reaction. Hydroxyl Radical 131-147 catalase Mus musculus 0-8 15469017-4 2004 Under the irradiation, the membrane-bound CIC1 and CIC2 are characterized by high quantum yields of singlet oxygen generation (0.6 and 0.65, respectively) and the inability to produce hydroxyl radicals. Hydroxyl Radical 184-201 chloride voltage-gated channel 2 Homo sapiens 51-55 15515950-10 2004 The affinity of edge hydroxyl to Cd2+ would lead to the difference of Cd2+ desorption rate and amounts. Hydroxyl Radical 21-29 CD2 molecule Homo sapiens 70-73 15207648-10 2004 Induction of HO-1 by Pb2+ is reduced by the hydroxyl radical scavengers dimethylthiourea (DMTU) and mannitol, but not by inhibitors of calmodulin, calmodulin-dependent protein kinases, protein kinase C, or extracellular signal-regulated kinases (ERK). Hydroxyl Radical 44-60 heme oxygenase 1 Homo sapiens 13-17 15215598-0 2004 Egg yolk phosvitin inhibits hydroxyl radical formation from the fenton reaction. Hydroxyl Radical 28-36 casein kinase 2 beta Homo sapiens 9-18 15212484-0 2004 Biochemical susceptibility of myosin in chicken myofibrils subjected to hydroxyl radical oxidizing systems. Hydroxyl Radical 72-88 myosin, heavy chain 15 Gallus gallus 30-36 15212484-1 2004 Biochemical changes of myosin in chicken myofibrils exposed to nonenzymatic, hydroxyl radical generation systems (HRGS) were investigated by means of cross-linking reaction, ATPase activity, salt solubility, and 40% saturated ammonium sulfate (AS) extractability. Hydroxyl Radical 77-93 myosin, heavy chain 15 Gallus gallus 23-29 15182858-5 2004 Blocking the iron-driven generation of lipid peroxides and hydroxyl radicals by different iron chelators led to a decrease in UVA-induced MMP-1 mRNA accumulation. Hydroxyl Radical 59-76 matrix metallopeptidase 1 Homo sapiens 138-143 14722014-2 2004 Catalase is an important antioxidant enzyme regulating the level of intracellular hydrogen peroxide and hydroxyl radicals. Hydroxyl Radical 104-121 catalase Mus musculus 0-8 15215598-2 2004 In this study, we investigated the effect of phosvitin on Fe(II)-catalyzed hydroxyl radical ((.-)OH) formation from H(2)O(2) in the Fenton reaction system. Hydroxyl Radical 75-91 casein kinase 2 beta Homo sapiens 45-54 15080932-3 2004 (R)-N-Hydroxy-N-sulfamoyl-beta-phenylalanine (8) was shown to be also a potent CPA inhibitor (Ki = 39 microM), the high potency of which may be ascribed to the involvement of the hydroxyl in the binding of CPA, most likely forming bidentate coordinative bonds to the zinc ion in CPA together with the sulfamoyl oxygen atom. Hydroxyl Radical 179-187 carboxypeptidase A1 Homo sapiens 79-82 15167267-11 2004 Benidipine and SNAP significantly decreased myocardial interstitial 2,5-DHBA levels, an indicator of hydroxyl radicals, during ischemia and reperfusion. Hydroxyl Radical 101-118 synaptosomal-associated protein 25 Oryctolagus cuniculus 15-19 15094365-7 2004 For hydroxyl radical, antimycin A abolishes the suppression caused by both ferrocytochrome c and ferricytochrome c. These results indicate that the reductive state of cytochrome c caused by electron-flow is necessary and sufficient for the operation of cytochrome c-mediated electron-leakage pathway. Hydroxyl Radical 4-20 cytochrome c, somatic Homo sapiens 80-92 15094365-7 2004 For hydroxyl radical, antimycin A abolishes the suppression caused by both ferrocytochrome c and ferricytochrome c. These results indicate that the reductive state of cytochrome c caused by electron-flow is necessary and sufficient for the operation of cytochrome c-mediated electron-leakage pathway. Hydroxyl Radical 4-20 cytochrome c, somatic Homo sapiens 102-114 15075214-7 2004 In contrast, the data obtained suggest that the increase in hydroxyl radical concentration in the extracellular space of muscles from wild-type mice after the contraction protocol most likely results from degradation of hydrogen peroxide generated by MnSOD activity. Hydroxyl Radical 60-76 superoxide dismutase 2, mitochondrial Mus musculus 251-256 21782712-2 2004 In the present study, SNL glycoprotein showed a dose-dependent radical scavenging activity on radicals, including 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, hydroxyl radical (OH), and superoxide anion (O(2)(-)). Hydroxyl Radical 161-177 fascin actin-bundling protein 1 Homo sapiens 22-25 15134512-7 2004 ROS (e.g., superoxide, peroxynitrite, hydroxyl radical and hydrogen peroxide) are all potential reactants capable of initiating DNA single strand breakage, with subsequent activation of the nuclear enzyme poly (ADP ribose) synthetase (PARS), leading to eventual severe energy depletion of the cells, and necrotic-type cell death. Hydroxyl Radical 38-54 poly(ADP-ribose) polymerase 1 Homo sapiens 205-233 15231412-6 2004 Nine mono-, di-, tri- and tetrahydroxychalcones were tested as inhibitors of tyrosinase mono- and diphenolase activities, showing that the most important factor in their efficacy is the location of the hydroxyl groups on both aromatic rings, with a significant preference to a 4-substituted B ring, rather than a substituted A ring. Hydroxyl Radical 202-210 tyrosinase Homo sapiens 77-87 15080651-4 2004 AAH and GAH also exhibited activities against peroxynitrite-mediated dihydrorhodamine 123 oxidations and hydroxyl radical-mediated DNA damage. Hydroxyl Radical 105-121 aspartate beta-hydroxylase Homo sapiens 0-3 15080651-4 2004 AAH and GAH also exhibited activities against peroxynitrite-mediated dihydrorhodamine 123 oxidations and hydroxyl radical-mediated DNA damage. Hydroxyl Radical 105-121 guanine deaminase Homo sapiens 8-11 15287192-1 2004 BACKGROUND: There is now good evidence to suggest that cytochrome P450 (CYP450) may act as an iron-donating catalyst for the production of hydroxyl ion (OH*), which contributes to proximal tubular cell injury. Hydroxyl Radical 139-147 cytochrome P450 family 2 subfamily D member 6 Sus scrofa 55-70 15055995-5 2004 These structures show the conservation of the VDR structure and the adaptation of the side chain anchored by hydroxyl moieties. Hydroxyl Radical 109-117 vitamin D receptor Homo sapiens 46-49 14576080-5 2004 In addition, the iron chelator 1,2-dimethyl-3-hydroxypyridin-4-one and the hydroxyl radical scavengers dimethylthiourea and dimethyl sulfoxide inhibited TNF-alpha-induced MCP-1 expression, suggesting important roles of iron and hydroxyl radicals in inflammatory signal activation. Hydroxyl Radical 75-91 tumor necrosis factor Mus musculus 153-162 14576080-5 2004 In addition, the iron chelator 1,2-dimethyl-3-hydroxypyridin-4-one and the hydroxyl radical scavengers dimethylthiourea and dimethyl sulfoxide inhibited TNF-alpha-induced MCP-1 expression, suggesting important roles of iron and hydroxyl radicals in inflammatory signal activation. Hydroxyl Radical 75-91 chemokine (C-C motif) ligand 2 Mus musculus 171-176 14576080-5 2004 In addition, the iron chelator 1,2-dimethyl-3-hydroxypyridin-4-one and the hydroxyl radical scavengers dimethylthiourea and dimethyl sulfoxide inhibited TNF-alpha-induced MCP-1 expression, suggesting important roles of iron and hydroxyl radicals in inflammatory signal activation. Hydroxyl Radical 228-245 tumor necrosis factor Mus musculus 153-162 15019574-2 2004 The time-dependent expression of MnSOD and HO-1 mRNAs and proteins was investigated in vitro in rat cerebral endothelial cells (CEC) subjected to sublethal mild or moderate hydroxyl radical-induced oxidative stress. Hydroxyl Radical 173-189 superoxide dismutase 2 Rattus norvegicus 33-38 15019574-2 2004 The time-dependent expression of MnSOD and HO-1 mRNAs and proteins was investigated in vitro in rat cerebral endothelial cells (CEC) subjected to sublethal mild or moderate hydroxyl radical-induced oxidative stress. Hydroxyl Radical 173-189 heme oxygenase 1 Rattus norvegicus 43-47 15104111-6 2004 The inactivation of PON1, either purified or HDL-bound, by ascorbate/Cu2+ was prevented by catalase or thiols, but not general hydroxyl radical scavengers, suggesting the involvement of Cu(2+)-catalyzed oxidation in PON1 inactivation. Hydroxyl Radical 127-135 paraoxonase 1 Homo sapiens 20-24 15287192-1 2004 BACKGROUND: There is now good evidence to suggest that cytochrome P450 (CYP450) may act as an iron-donating catalyst for the production of hydroxyl ion (OH*), which contributes to proximal tubular cell injury. Hydroxyl Radical 139-147 cytochrome P450 family 2 subfamily D member 6 Sus scrofa 72-78 15036353-9 2004 We conclude that toxic Abeta peptides do indeed stimulate copper-mediated oxidation of ascorbate and generation of hydroxyl radicals. Hydroxyl Radical 115-132 amyloid beta precursor protein Homo sapiens 23-28 14729335-3 2004 Previously, directed hydroxyl radical probing from Fe(II)-S15 in small ribonucleoprotein complexes was used to study assembly of the central domain of 16 S rRNA. Hydroxyl Radical 21-37 ribosomal protein S15 Homo sapiens 58-61 14732219-4 2004 Of these, CYP1A2, 2B1, 2C11 and 3A2 produced hydroxyl radicals efficiently. Hydroxyl Radical 45-62 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 10-16 14732219-5 2004 Phenobarbital (PB) which is a typical inducer of CYP2B1 and 3A2 induced production of hydroxyl radicals by rat liver and ketoconazole, an inhibitor of P450, inhibited production of hydroxyl radicals in vitro. Hydroxyl Radical 86-103 cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus 49-55 14732219-5 2004 Phenobarbital (PB) which is a typical inducer of CYP2B1 and 3A2 induced production of hydroxyl radicals by rat liver and ketoconazole, an inhibitor of P450, inhibited production of hydroxyl radicals in vitro. Hydroxyl Radical 181-198 cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus 49-55 16328846-0 2004 Superoxide, Hydrogen Peroxide and Hydroxyl Radical in D1/D2/cytochrome b-559 Photosystem II Reaction Center Complex. Hydroxyl Radical 34-50 leiomodin 1 Homo sapiens 54-59 14581474-6 2004 Hydroxyl radical footprints indicate that Rnt1p specifically interacts with the NGNN tetraloop and its surrounding nucleotides. Hydroxyl Radical 0-16 ribonuclease III Saccharomyces cerevisiae S288C 42-47 16328846-0 2004 Superoxide, Hydrogen Peroxide and Hydroxyl Radical in D1/D2/cytochrome b-559 Photosystem II Reaction Center Complex. Hydroxyl Radical 34-50 mitochondrially encoded cytochrome b Homo sapiens 60-72 16328846-1 2004 Spin-trapping electron spin resonance (ESR) was used to monitor the formation of superoxide and hydroxyl radicals in D1/D2/cytochrome b-559 Photosystem II reaction center (PS II RC) Complex. Hydroxyl Radical 96-113 leiomodin 1 Homo sapiens 117-122 16328846-1 2004 Spin-trapping electron spin resonance (ESR) was used to monitor the formation of superoxide and hydroxyl radicals in D1/D2/cytochrome b-559 Photosystem II reaction center (PS II RC) Complex. Hydroxyl Radical 96-113 mitochondrially encoded cytochrome b Homo sapiens 123-135 14646314-2 2003 In the region of delta 5.0-4.0, the signals of H-1 attached to the same carbon with a hydroxyl, were well separated from each other in CDCl(3). Hydroxyl Radical 86-94 H1.5 linker histone, cluster member Homo sapiens 47-50 16268121-6 2004 alpha-Tocopherol suppressed the hydroxyl radical-induced lipid peroxidation, swelling and cytochrome c release from mitochondria. Hydroxyl Radical 32-48 cytochrome c, somatic Homo sapiens 90-102 14974735-1 2003 An attempt to synthesize 6-hydroxypyridoxine (OPN), hydroxylation on C-6 of pyridoxine (PN) by hydroxyl radical (OH*). Hydroxyl Radical 95-111 secreted phosphoprotein 1 Homo sapiens 46-49 14871032-0 2003 Direct evidence for increased hydroxyl radicals in angiotensin II-induced cardiac hypertrophy through angiotensin II type 1a receptor. Hydroxyl Radical 30-47 angiotensin II receptor, type 1a Mus musculus 102-133 12960013-6 2003 We suggested that this additional complement pathway requires the production of ROS and specially hydroxyl radicals that aggregate TPO and oxidize methionines of C4. Hydroxyl Radical 98-115 thyroid peroxidase Homo sapiens 131-134 14753756-2 2003 Here, we attempted to elucidate the possible mechanisms for the oxidative inactivation of PON1, and to examine the capability of hydroxyl radicals-inactivated PON1 to prevent against LDL oxidation. Hydroxyl Radical 129-146 paraoxonase 1 Homo sapiens 159-163 14753756-6 2003 The inactivation of PON1 by ascorbate/Cu2+ was pevented by catalase, but not general hydroxyl radical scavengers, supporting inactivation. Hydroxyl Radical 85-101 paraoxonase 1 Homo sapiens 20-24 14600024-0 2003 Position of eukaryotic initiation factor eIF1 on the 40S ribosomal subunit determined by directed hydroxyl radical probing. Hydroxyl Radical 98-114 eukaryotic translation initiation factor 1 Homo sapiens 41-45 14581171-9 2003 The generation of hydroxyl radicals was inhibited by radical scavenger, catalase, and copper chelator. Hydroxyl Radical 18-35 catalase Homo sapiens 72-80 14600024-3 2003 The cleavage of 18S rRNA in helices 23b, 24a, and 44 by hydroxyl radicals generated from Fe(II) tethered to seven positions on the surface of eIF1 places eIF1 on the interface surface of the platform of the 40S subunit in the proximity of the ribosomal P-site. Hydroxyl Radical 56-73 eukaryotic translation initiation factor 1 Homo sapiens 142-146 14600024-3 2003 The cleavage of 18S rRNA in helices 23b, 24a, and 44 by hydroxyl radicals generated from Fe(II) tethered to seven positions on the surface of eIF1 places eIF1 on the interface surface of the platform of the 40S subunit in the proximity of the ribosomal P-site. Hydroxyl Radical 56-73 eukaryotic translation initiation factor 1 Homo sapiens 154-158 14567450-6 2003 Our results demonstrate that ascorbic acid can induce a pH dependent hydroxyl radical generating reaction in copper contaminated household tap water that is buffered with bicarbonate. Hydroxyl Radical 69-85 nuclear RNA export factor 1 Homo sapiens 139-142 14580322-5 2003 Here we examined the effect of citicoline on PLA2 activity in relationship to attenuating hydroxyl radical (OH*) generation and lipid peroxidation after transient forebrain ischemia in gerbil. Hydroxyl Radical 90-106 phospholipase A2 group IB Homo sapiens 45-49 12909277-6 2003 Furthermore, the SNL extract was revealed to be a potential scavenger of hydroxyl radicals and DPPH radicals rather than superoxide anions. Hydroxyl Radical 73-90 fascin actin-bundling protein 1 Homo sapiens 17-20 14527082-6 2003 CYP2E1 is also an effective generator of reactive oxygen species such as the superoxide anion radical and hydrogen peroxide, and in the presence of iron catalysts, produces powerful oxidants such as the hydroxyl radical. Hydroxyl Radical 203-219 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 0-6 12918051-0 2003 Deposition of complement protein C3b on mixed self-assembled monolayers carrying surface hydroxyl and methyl groups studied by surface plasmon resonance. Hydroxyl Radical 89-97 endogenous retrovirus group K member 3 Homo sapiens 33-36 12918051-6 2003 These results clearly demonstrate that a large amount of C3b, produced through the activation of the complement system, binds covalently to and is adsorbed by hydroxyl-group-rich surfaces. Hydroxyl Radical 159-167 endogenous retrovirus group K member 3 Homo sapiens 57-60 14532906-12 2003 The protective effects of hydroxyl radical scavengers are associated with an inhibition of cytochrome c release and caspase activation. Hydroxyl Radical 26-42 cytochrome c Oryctolagus cuniculus 91-103 14742143-11 2003 The potency of the inhibition for SULT1A1 (quercetin > kaempferol > genistein > daidzein) suggests a dependency on the number and position of hydroxyl radicals in the flavonoid molecule. Hydroxyl Radical 151-168 sulfotransferase family 1A member 1 Rattus norvegicus 34-41 14580189-3 2003 We used hydroxyl radical-mediated protein footprinting and mass spectrometry to reveal the conformational changes that occur upon complex formation for the human transferrin C-lobe (residues 334-679) bound to the ectodomain of human transferrin receptor 1 (residues 121-760). Hydroxyl Radical 8-24 transferrin Homo sapiens 162-173 14580189-3 2003 We used hydroxyl radical-mediated protein footprinting and mass spectrometry to reveal the conformational changes that occur upon complex formation for the human transferrin C-lobe (residues 334-679) bound to the ectodomain of human transferrin receptor 1 (residues 121-760). Hydroxyl Radical 8-24 transferrin Homo sapiens 233-244 12680700-0 2003 Interactions of growth inhibitory factor with hydroxyl and superoxide radicals. Hydroxyl Radical 46-54 metallothionein 3 Homo sapiens 16-40 14604470-2 2003 RP-1, under in-vitro conditions dose-dependently chelated metal ions, inhibited radiation or metal ion-induced hydroxyl radicals and lipid peroxidation and scavenged superoxide anions. Hydroxyl Radical 111-128 retinitis pigmentosa 1 (human) Mus musculus 0-4 12868064-5 2003 We examined the effect of citicoline on phospholipase A(2) (PLA(2)) activity in relation to the attenuation of hydroxyl radical (OH.) Hydroxyl Radical 111-127 phospholipase A2 group IB Homo sapiens 40-58 12868064-5 2003 We examined the effect of citicoline on phospholipase A(2) (PLA(2)) activity in relation to the attenuation of hydroxyl radical (OH.) Hydroxyl Radical 111-127 phospholipase A2 group IB Homo sapiens 60-66 14514473-6 2003 In addition, the quantitative determination of PAF and hydroxyl-PAF analogue (expressed as PAF-like activity) showed a statistically significant increase in the ratio of hydroxyl-PAF analogue levels to PAF levels in periodontal patients, suggesting that this bioactive lipid may play a role in oral inflammation. Hydroxyl Radical 55-63 PCNA clamp associated factor Homo sapiens 64-67 14514473-6 2003 In addition, the quantitative determination of PAF and hydroxyl-PAF analogue (expressed as PAF-like activity) showed a statistically significant increase in the ratio of hydroxyl-PAF analogue levels to PAF levels in periodontal patients, suggesting that this bioactive lipid may play a role in oral inflammation. Hydroxyl Radical 55-63 PCNA clamp associated factor Homo sapiens 64-67 14514473-6 2003 In addition, the quantitative determination of PAF and hydroxyl-PAF analogue (expressed as PAF-like activity) showed a statistically significant increase in the ratio of hydroxyl-PAF analogue levels to PAF levels in periodontal patients, suggesting that this bioactive lipid may play a role in oral inflammation. Hydroxyl Radical 55-63 PCNA clamp associated factor Homo sapiens 64-67 14514473-6 2003 In addition, the quantitative determination of PAF and hydroxyl-PAF analogue (expressed as PAF-like activity) showed a statistically significant increase in the ratio of hydroxyl-PAF analogue levels to PAF levels in periodontal patients, suggesting that this bioactive lipid may play a role in oral inflammation. Hydroxyl Radical 55-63 PCNA clamp associated factor Homo sapiens 64-67 12901850-4 2003 The transcriptional activation of IL-8 gene was not affected by sodium formate or sodium salicylate, suggesting that suppression of the IL-8 gene induction is specific to the class of hydroxyl radical scavenger used. Hydroxyl Radical 184-200 C-X-C motif chemokine ligand 8 Homo sapiens 34-38 12848515-2 2003 The purified patatin showed antioxidant or antiradical activity by a series of in vitro tests, including 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical (half-inhibition concentration, IC(50), was 0.582 mg/mL) scavenging activity assays, anti-human low-density lipoprotein peroxidation tests, and protections against hydroxyl radical-mediated DNA damages and peroxynitrite-mediated dihydrorhodamine 123 oxidations. Hydroxyl Radical 314-330 Patatin class I Solanum tuberosum 13-20 12848515-3 2003 Using electron paramagnetic resonance (EPR) spectrometry for hydroxyl radical detections, it was found that the intensities of the EPR signal were decreased by the increased amounts of patatin added (IC(50) was 0.775 mg/mL). Hydroxyl Radical 61-77 Patatin class I Solanum tuberosum 185-192 12848515-4 2003 Through modifications of patatin by iodoacetamide or N-bromosuccinimide, it was found that the antiradical activities of modified patatin against DPPH or hydroxyl radicals were decreased. Hydroxyl Radical 154-171 Patatin class I Solanum tuberosum 25-32 12848515-4 2003 Through modifications of patatin by iodoacetamide or N-bromosuccinimide, it was found that the antiradical activities of modified patatin against DPPH or hydroxyl radicals were decreased. Hydroxyl Radical 154-171 Patatin class I Solanum tuberosum 130-137 12837111-3 2003 On dense SAMs, hydroxyl ions are highly mobile. Hydroxyl Radical 15-23 methionine adenosyltransferase 1A Homo sapiens 9-13 12807725-3 2003 The gas phase of CS contains free radicals such as superoxide radicals, hydroxyl radicals and hydrogen peroxide, which potentially can activate NF-kappaB. Hydroxyl Radical 72-89 nuclear factor kappa B subunit 1 Homo sapiens 144-153 12739149-0 2003 Evidence for the involvement of cell wall peroxidase in the generation of hydroxyl radicals mediating extension growth. Hydroxyl Radical 74-91 peroxidase 1 Zea mays 42-52 12901672-7 2003 Hydroxyl radical attack on the conjugated diene structure of Adda moiety produced dihyroxylated products. Hydroxyl Radical 0-16 adducin 1 Homo sapiens 61-65 12901850-7 2003 Therefore, it seems likely that in U937 cells, hydroxyl radicals or species with reactivity similar to hydroxyl radicals contribute to NO-mediated IL-8 gene induction. Hydroxyl Radical 47-64 C-X-C motif chemokine ligand 8 Homo sapiens 147-151 12901850-7 2003 Therefore, it seems likely that in U937 cells, hydroxyl radicals or species with reactivity similar to hydroxyl radicals contribute to NO-mediated IL-8 gene induction. Hydroxyl Radical 103-120 C-X-C motif chemokine ligand 8 Homo sapiens 147-151 12901850-4 2003 The transcriptional activation of IL-8 gene was not affected by sodium formate or sodium salicylate, suggesting that suppression of the IL-8 gene induction is specific to the class of hydroxyl radical scavenger used. Hydroxyl Radical 184-200 C-X-C motif chemokine ligand 8 Homo sapiens 136-140 12916842-7 2003 Additionally, the rate constant of the reaction between hydroxyl radicals and LAS in the oxidising system H2O2/UV is determined for different operational conditions. Hydroxyl Radical 56-73 lipoic acid synthetase Homo sapiens 78-81 12860055-5 2003 The hydroxyl radical level in liver positively correlated with the activities of glutathione reductase (r=0.464, P<0.05) and superoxide dismutase (r=0.549, P<0.05). Hydroxyl Radical 4-20 glutathione-disulfide reductase Rattus norvegicus 81-102 12527286-6 2003 An electron spin resonance study clearly demonstrated the ability of metal ions to generate activated oxygen species (AOS), especially hydroxyl radicals (*OH), which accounts for PDTC-blockade of metal ion-induced NF-kappaB activation and subsequent cytokine production. Hydroxyl Radical 135-152 nuclear factor kappa B subunit 1 Homo sapiens 214-223 12726917-8 2003 Electron paramagnetic resonance reveals that the intracellular generation of hydroxyl radical following addition of hydrogen peroxide to J774 cells is totally eliminated by pretreatment with either DFO (1 mM) or LAP (0.2 microM) whereas LM (200 microM) is much less effective. Hydroxyl Radical 77-93 acid phosphatase, prostate Mus musculus 212-215 12723949-17 2003 At the NK1 receptor of substance P (SP), the free hydroxyl at C4 optimizes affinity. Hydroxyl Radical 50-58 tachykinin receptor 1 Homo sapiens 7-19 12723949-17 2003 At the NK1 receptor of substance P (SP), the free hydroxyl at C4 optimizes affinity. Hydroxyl Radical 50-58 tachykinin precursor 1 Homo sapiens 23-34 12723949-17 2003 At the NK1 receptor of substance P (SP), the free hydroxyl at C4 optimizes affinity. Hydroxyl Radical 50-58 tachykinin precursor 1 Homo sapiens 36-38 12675844-12 2003 Direct incubation of cisplatin with the microsomes isolated from CYP2e1-/- kidney cortex produced significant decrease in the generation of hydrogen peroxide, catalytic iron content, and hydroxyl radical formation compared to CYP2e1+/+ microsomes. Hydroxyl Radical 187-203 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 65-71 12849078-0 2003 Pyridoindole antioxidant stobadine protected bovine serum albumin against the hydroxyl radical mediated cross-linking in vitro. Hydroxyl Radical 78-94 albumin Homo sapiens 52-65 12696863-4 2003 The (1h)J(2"OH,N) cross hydrogen bond scalar coupling constant determined from a quantitative 1D (15N) spin-echo difference experiment for the C15/A27 interaction is 1.7 +/- 0.1 Hz, while that for the C16/A25 interaction appears larger, 3.5 +/- 0.3 Hz, despite the fact that the corresponding direct correlation between the 2"-OH hydroxyl proton of C16 and the N1 of A25 is missing due to unfavorable solvent exchange properties. Hydroxyl Radical 330-338 placenta associated 8 Homo sapiens 143-146 12823903-7 2003 This effect is very likely due to vimentin-induced structural distortion of the branchpoint, as suggested by the results of hydroxyl radical footprinting of Holliday junctions in the absence and the presence of vimentin. Hydroxyl Radical 124-140 vimentin Homo sapiens 34-42 12591250-0 2003 Light-induced formation of hydroxyl radicals in fog waters determined by an authentic fog constituent, hydroxymethanesulfonate. Hydroxyl Radical 27-44 zinc finger protein, FOG family member 1 Homo sapiens 48-51 12591250-0 2003 Light-induced formation of hydroxyl radicals in fog waters determined by an authentic fog constituent, hydroxymethanesulfonate. Hydroxyl Radical 27-44 zinc finger protein, FOG family member 1 Homo sapiens 86-89 12623292-0 2003 The effect of hyaluronan on CD44-mediated survival of normal and hydroxyl radical-damaged chondrocytes. Hydroxyl Radical 65-81 CD44 molecule (Indian blood group) Homo sapiens 28-32 12661766-6 2003 These results suggest that the oligomerization of alpha-synuclein is mediated by the generation of the hydroxyl radical through the metal-catalyzed reaction. Hydroxyl Radical 103-119 synuclein alpha Homo sapiens 50-65 12575998-4 2003 In addition, hydroxyl-radical probings of RRF on the ribosome are not in agreement with the simple idea that RRF mimics tRNA in the ribosome A-site. Hydroxyl Radical 13-21 mitochondrial ribosome recycling factor Homo sapiens 42-45 12626123-2 2003 The aim of the present study was to determine whether N-(2-mercaptopropionyl)glycine (MPG), a cell-diffusible hydroxyl radical scavenger, and carnosine, a potent singlet oxygen quencher, could block protection afforded by a single cycle of ischemic preconditioning in vivo in the rat. Hydroxyl Radical 110-118 N-methylpurine-DNA glycosylase Rattus norvegicus 86-89 12388222-0 2003 Overexpression of tumor necrosis factor-alpha increases production of hydroxyl radical in murine myocardium. Hydroxyl Radical 70-86 tumor necrosis factor Mus musculus 18-45 12682431-0 2003 Induction of interleukin-6 by coal containing bioavailable iron is through both hydroxyl radical and ferryl species. Hydroxyl Radical 80-96 interleukin 6 Homo sapiens 13-26 12682431-10 2003 Our results indicate that BAI in the PA coal may induce IL-6 through both ferryl species (via iron autoxidation) and hydroxyl radicals (via the Fenton/Haber Weiss reactions). Hydroxyl Radical 117-134 interleukin 6 Homo sapiens 56-60 12949623-1 2003 The rate constants of the reactions of alcohol dehydrogenase and glyceraldehyde-3-phosphate dehydrogenase with hydroxyl radicals were determined using the method of steady-state competitive reactions. Hydroxyl Radical 111-128 aldo-keto reductase family 1 member A1 Homo sapiens 39-60 12949623-0 2003 The rate constants of the reaction of hydroxyl radicals (*OH) with alcohol dehydrogenase and Glyceraldehyde-3-phosphate dehydrogenase. Hydroxyl Radical 38-55 aldo-keto reductase family 1 member A1 Homo sapiens 67-88 12949623-0 2003 The rate constants of the reaction of hydroxyl radicals (*OH) with alcohol dehydrogenase and Glyceraldehyde-3-phosphate dehydrogenase. Hydroxyl Radical 38-55 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 93-133 12949623-1 2003 The rate constants of the reactions of alcohol dehydrogenase and glyceraldehyde-3-phosphate dehydrogenase with hydroxyl radicals were determined using the method of steady-state competitive reactions. Hydroxyl Radical 111-128 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 65-105 12949623-3 2003 The rate constants of the reactions of hydroxyl radicals with alcohol dehydrogenase and glyceraldehyde-3-phosphate dehydrogenase were found to be 2.8 x 10(12) dm(3) mol(-1) s(-1), and 1.6 x 10(12) dm(3) mol(-1) s(-1), respectively. Hydroxyl Radical 39-56 aldo-keto reductase family 1 member A1 Homo sapiens 62-83 12949623-3 2003 The rate constants of the reactions of hydroxyl radicals with alcohol dehydrogenase and glyceraldehyde-3-phosphate dehydrogenase were found to be 2.8 x 10(12) dm(3) mol(-1) s(-1), and 1.6 x 10(12) dm(3) mol(-1) s(-1), respectively. Hydroxyl Radical 39-56 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 88-128 12379471-8 2002 On the other hand, HBO-exposed lymphocytes showed a small but reproducible increase in cellular ferritin levels, which might indicate that the underlying protective mechanism is based on an induction of ferritin, which may act antioxidatively by preventing the generation of the DNA-damaging hydroxyl radical via Fenton reaction. Hydroxyl Radical 292-308 ferritin, mitochondrial Cricetulus griseus 96-104 12806184-6 2003 Preincubating GEC with CYP2B1 inhibitors (piperine and cimetidine) and H(2)O(2) scavenger (pyruvate) significantly reduced H(2)O(2 )generation, preserved CYP2B1 content, prevented the increase in catalytic iron and hydroxyl radical formation including PAN-induced cytotoxicity. Hydroxyl Radical 215-231 cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus 23-29 12445862-15 2002 This mechanism was shown to trigger the formation of hydroxyl radicals from H(2)O(2) and to cause an oxidation of the antioxidant ceruloplasmin. Hydroxyl Radical 53-70 ceruloplasmin Canis lupus familiaris 130-143 12542872-13 2002 Hydroxyl radical production was greatest at F2-2 cm (0.384 +/- 0.035 microM) and decreased significantly distal to this position. Hydroxyl Radical 0-16 coagulation factor II, thrombin Sus scrofa 44-48 12423653-3 2002 Addition of catalase protected DNA from the gallic acid/copper-dependent strand breaks and the formation of 8-hydroxy-2"-deoxyguanosine, indicating that hydroxyl radical may participate in the DNA damage. Hydroxyl Radical 153-169 catalase Bos taurus 12-20 12228253-6 2002 The higher affinity of SHBG for estradiol derivatives with a halogen atom at C-2 is due to either enhanced hydrogen bonding between the hydroxyl at C-3 and Asp(65) (2-fluoroestradiol) or accommodation of the functional group at C-2 (2-bromoestradiol), rather than an interaction with Asn(82). Hydroxyl Radical 136-144 sex hormone binding globulin Homo sapiens 23-27 12228253-6 2002 The higher affinity of SHBG for estradiol derivatives with a halogen atom at C-2 is due to either enhanced hydrogen bonding between the hydroxyl at C-3 and Asp(65) (2-fluoroestradiol) or accommodation of the functional group at C-2 (2-bromoestradiol), rather than an interaction with Asn(82). Hydroxyl Radical 136-144 complement C2 Homo sapiens 77-80 12419257-12 2002 As judged by hydroxyl radical footprinting and the missing nucleoside experiment, it appears that interaction of the Ubx recognition helix with the DNA major groove is reduced. Hydroxyl Radical 13-29 Ultrabithorax Drosophila melanogaster 117-120 15068240-9 2003 We examined the SOD1 to GPX1 mRNA ratio in individual organs, as both enzymes form part of the body"s defense against oxidative stress, and because a disproportionate increase of SOD1 to GPX1 results in noxious hydroxyl radical damage. Hydroxyl Radical 211-227 superoxide dismutase 1 Homo sapiens 179-183 15068240-9 2003 We examined the SOD1 to GPX1 mRNA ratio in individual organs, as both enzymes form part of the body"s defense against oxidative stress, and because a disproportionate increase of SOD1 to GPX1 results in noxious hydroxyl radical damage. Hydroxyl Radical 211-227 glutathione peroxidase 1 Homo sapiens 187-191 12509466-5 2003 Directed hydroxyl radical probing, done by using Fe(II) tethered to surface residues in eIF4G"s central domain, indicated that it is oriented with its N terminus towards the base of domain J and its C terminus towards the apex. Hydroxyl Radical 9-25 eukaryotic translation initiation factor 4 gamma 1 Homo sapiens 88-93 12354778-10 2002 Interestingly, hydroxyl radical footprinting revealed that the Zeste-DNA backbone contacts all map to one face of the DNA. Hydroxyl Radical 15-31 zeste Drosophila melanogaster 63-68 12530078-2 2002 ESR spectroscopy shows that these extracts produced radicals under alkaline condition, and scavenged radicals such as superoxide anion, hydroxyl radical and nitric oxide (NO) radical. Hydroxyl Radical 136-152 esterase 5 regulator Mus musculus 0-3 12592667-0 2002 Reduced serum hydroxyl radical scavenging activity in erythropoietin therapy resistant renal anemia. Hydroxyl Radical 14-30 erythropoietin Homo sapiens 54-68 16120311-4 2002 Frataxin may be a mitochondrial iron-binding protein that prevents this metal from participating in Fenton chemistry to generate toxic hydroxyl radicals. Hydroxyl Radical 135-152 frataxin Homo sapiens 0-8 12379471-8 2002 On the other hand, HBO-exposed lymphocytes showed a small but reproducible increase in cellular ferritin levels, which might indicate that the underlying protective mechanism is based on an induction of ferritin, which may act antioxidatively by preventing the generation of the DNA-damaging hydroxyl radical via Fenton reaction. Hydroxyl Radical 292-308 ferritin, mitochondrial Cricetulus griseus 203-211 12270752-4 2002 Adrenaline augmented hydroxyl radicals in a concentration-dependent manner and was blocked by chloroethylclonidine, an alpha(1B)-adrenoceptor antagonist, while adrenaline plus ethanol added their individual effects. Hydroxyl Radical 21-38 adrenoceptor alpha 1B Rattus norvegicus 119-141 12209459-1 2002 The generation of singlet molecular oxygen ((1)O(2)) and hydroxyl radicals (HO*) during peroxidation of bopindolol in the presence of Co(II) ions was studied using electron spin resonance (ESR) and spectrophotometry methods. Hydroxyl Radical 57-74 mitochondrially encoded cytochrome c oxidase II Homo sapiens 134-140 12270752-5 2002 It is suggested that adrenaline increases hydroxyl radicals by an alpha(1B)-adrenoceptor-mediated mechanism, while ethanol does so by a receptor-independent mechanism. Hydroxyl Radical 42-59 adrenoceptor alpha 1B Rattus norvegicus 66-88 12400927-1 2002 A detailed investigation on the kinetics of the oxidative degradation of a reactive dye, C. I. Reactive Red 2 by hydroxyl radicals generated by H202 and Fe2+ has been carried out in aqueous acidic media. Hydroxyl Radical 113-130 adenosine deaminase RNA specific B2 (inactive) Homo sapiens 104-109 12383939-2 2002 To investigate the defensive role of MT-III in terms of hydroxyl radical-induced DNA damage, we used purified human MT-III. Hydroxyl Radical 56-72 metallothionein 3 Homo sapiens 37-43 12121079-4 2002 OD is formed from both alkenes, indicating a pathway of hydroxyl-radical formation involving vinylic hydrogens, accounting for one-third of total OH formation from cis-3-hexene. Hydroxyl Radical 56-64 suppressor of cytokine signaling 3 Homo sapiens 164-169 12221060-3 2002 METHODS AND RESULTS: The in vitro study showed that TRX1 was dose-dependently increased concomitant with the formation of hydroxyl radicals in ADR-treated neonatal rat cardiomyocytes. Hydroxyl Radical 122-139 thioredoxin 1 Mus musculus 52-56 12221060-8 2002 The formation of hydroxyl radicals in ADR-treated heart homogenates of TRX1-TG mice was decreased compared with WT mice. Hydroxyl Radical 17-34 thioredoxin 1 Mus musculus 71-75 12182580-1 2002 [reaction: see text] The use of Pd2dba3 with bulky, electron-rich ligands 1 or 2 and LiN(TMS)2 as the base for the coupling of amines with aryl halides containing hydroxyl, amide, or enolizable keto groups is described. Hydroxyl Radical 163-171 serine incorporator 1 Homo sapiens 89-94 11964141-7 2002 Bathocuproinedisulphonic acid as well as the hydroxyl radical scavenger d-mannitol inhibited the PDTC-dependent increase in p53 protein and oxidation. Hydroxyl Radical 45-61 tumor protein p53 Homo sapiens 124-127 12196137-9 2002 Toxicity induced by alpha-synuclein, NAC and NAC(1-18) oligomers occurs via an apoptotic mechanism, possibly initiated by oxidative damage, since these peptides liberate hydroxyl radicals in the presence of iron. Hydroxyl Radical 170-187 synuclein alpha Homo sapiens 20-35 12196137-9 2002 Toxicity induced by alpha-synuclein, NAC and NAC(1-18) oligomers occurs via an apoptotic mechanism, possibly initiated by oxidative damage, since these peptides liberate hydroxyl radicals in the presence of iron. Hydroxyl Radical 170-187 synuclein alpha Homo sapiens 37-40 12231557-3 2002 METHODS AND RESULTS: In the presence of HCO3-, SOD3 reacted with H2O2 to produce a hydroxyl radical adduct of the spin trap 5-diethoxyphosphoryl-5methyl-1-pyrroline N-oxide (DEMPO). Hydroxyl Radical 83-99 superoxide dismutase 3, extracellular Mus musculus 47-51 12372096-7 2002 When the controls plus various treatments with free radicals were subject to different antioxidants, including superoxide dismutase, catalase, glutathione peroxidase, and desferrioxamine, it was found that catalase alone was most effective in scavenging hydroxyl radicals as determined by the decrease in pyridinoline cross-links. Hydroxyl Radical 254-271 catalase Homo sapiens 206-214 12165299-0 2002 Polysaccharide degradation by Fenton reaction--or peroxidase-generated hydroxyl radicals in isolated plant cell walls. Hydroxyl Radical 71-88 peroxidase Glycine max 50-60 12115846-1 2002 Amphiphilic triblock copolymers, poly(epsilon-caprolactone)-poly(ethylene oxide)-poly(epsilon-caprolactone) (PCL-PEO-PCL), were synthesized by ring opening polymerization of epsilon-caprolactone initiated with the hydroxyl functional groups of poly(ethylene glycol) at both ends of the chain. Hydroxyl Radical 214-222 PHD finger protein 1 Homo sapiens 109-112 11994311-4 2002 Here, we examine the biochemical and biological importance of a conserved hydroxyl-bearing residue in signature motif A. Interestingly, one major exception is the Saccharomyces cerevisiae GCN5, where an alanine (Ala(190)) is located in the corresponding position. Hydroxyl Radical 74-82 lysine acetyltransferase 2A Homo sapiens 188-192 11994311-5 2002 In related GCN5 family structures, a hydroxyl-containing side chain residue is hydrogen-bonded to the alpha-phosphate oxygen of CoA. Hydroxyl Radical 37-45 lysine acetyltransferase 2A Homo sapiens 11-15 12069588-0 2002 Differential interactions of estrogens and antiestrogens at the 17 beta-hydroxyl or counterpart hydroxyl with histidine 524 of the human estrogen receptor alpha. Hydroxyl Radical 72-80 estrogen receptor 1 Homo sapiens 137-160 11937361-10 2002 In the complex of CPA small middle dotD-, the carboxylate of the inhibitor is engaged in hydrogen bonding with the phenolic hydroxyl of the down-positioned Tyr-248. Hydroxyl Radical 124-132 carboxypeptidase A1 Homo sapiens 18-21 12067251-10 2002 p53 mutagenesis by BP-7,8-dione was attenuated by ROS scavengers and completely abrogated by a combination of superoxide dismutase and catalase, indicating that both superoxide anion and hydroxyl radicals were the responsible mutagens. Hydroxyl Radical 187-204 tumor protein p53 Homo sapiens 0-3 12453634-5 2002 Hydroxyl radical scavengers and spin-trapping agent such as 5,5"-dimethyl 1-pyrolline N-oxide and tert-butyl-alpha-phenylnitrone significantly inhibited the aggregation of alpha-synuclein. Hydroxyl Radical 0-16 synuclein alpha Homo sapiens 172-187 12453634-7 2002 This indicates that the aggregation of alpha-synuclein can be mediated by the CP/H(2)O(2) system via the generation of hydroxyl radical. Hydroxyl Radical 119-135 synuclein alpha Homo sapiens 39-54 12453634-7 2002 This indicates that the aggregation of alpha-synuclein can be mediated by the CP/H(2)O(2) system via the generation of hydroxyl radical. Hydroxyl Radical 119-135 ceruloplasmin Homo sapiens 78-80 12087069-9 2002 GKLF induction by H-Fe is mediated through hydroxyl radicals, p38MAP kinase-, calcium-, and protein synthesis-dependent pathways. Hydroxyl Radical 43-60 Kruppel-like factor 4 (gut) Mus musculus 0-4 12031892-0 2002 Formation of hydrogen peroxide and hydroxyl radicals from A(beta) and alpha-synuclein as a possible mechanism of cell death in Alzheimer"s disease and Parkinson"s disease. Hydroxyl Radical 35-52 amyloid beta precursor protein Homo sapiens 58-65 12031892-0 2002 Formation of hydrogen peroxide and hydroxyl radicals from A(beta) and alpha-synuclein as a possible mechanism of cell death in Alzheimer"s disease and Parkinson"s disease. Hydroxyl Radical 35-52 synuclein alpha Homo sapiens 70-85 12031892-3 2002 We have shown recently that solutions of A(beta) 1-40, A(beta) 1-42, A(beta) 25-35, alpha-synuclein and non-A(beta) component (NAC; residues 61-95 of alpha-synuclein) all liberate hydroxyl radicals upon incubation in vitro followed by the addition of small amounts of Fe(II). Hydroxyl Radical 180-197 synuclein alpha Homo sapiens 127-130 12031892-5 2002 Hydroxyl radical formation was inhibited by the inclusion of catalase or metal-chelators during A(beta) or alpha-synuclein incubation. Hydroxyl Radical 0-16 amyloid beta precursor protein Homo sapiens 96-103 12031892-5 2002 Hydroxyl radical formation was inhibited by the inclusion of catalase or metal-chelators during A(beta) or alpha-synuclein incubation. Hydroxyl Radical 0-16 synuclein alpha Homo sapiens 107-122 12031892-6 2002 Our results suggest that hydrogen peroxide accumulates during the incubation of A(beta) or alpha-synuclein, by a metal-dependent mechanism, and that this is subsequently converted to hydroxyl radicals, on addition of Fe (II), by Fenton"s reaction. Hydroxyl Radical 183-200 amyloid beta precursor protein Homo sapiens 80-87 11821420-1 2002 Human DNA polymerase eta was used to copy four stereoisomeric deoxyguanosine (dG) adducts derived from benzo[a]pyrene 7,8-diol 9,10-epoxide (diastereomer with the 7-hydroxyl group and epoxide oxygen trans (BaP DE-2)). Hydroxyl Radical 165-173 DNA polymerase eta Homo sapiens 6-24 11982397-2 2002 The hydroxyl radical is generated by a Co(II)-mediated Fenton-like reaction, and the hydroxyl radical formation under the experimental condition is indirectly confirmed by the hydroxylation of p-hydroxybenzoic acid. Hydroxyl Radical 4-20 mitochondrially encoded cytochrome c oxidase II Homo sapiens 39-46 11982397-2 2002 The hydroxyl radical is generated by a Co(II)-mediated Fenton-like reaction, and the hydroxyl radical formation under the experimental condition is indirectly confirmed by the hydroxylation of p-hydroxybenzoic acid. Hydroxyl Radical 85-101 mitochondrially encoded cytochrome c oxidase II Homo sapiens 39-46 12020627-2 2002 Transferrin has also been proposed as a mediator of tubular toxicity because the reabsorption of transferrin results in the release of reactive iron in proximal tubular cells, promoting the formation of hydroxyl radicals. Hydroxyl Radical 203-220 transferrin Homo sapiens 0-11 12020627-2 2002 Transferrin has also been proposed as a mediator of tubular toxicity because the reabsorption of transferrin results in the release of reactive iron in proximal tubular cells, promoting the formation of hydroxyl radicals. Hydroxyl Radical 203-220 transferrin Homo sapiens 97-108 11875064-5 2002 Hydroxyl radical footprinting of DNA of sbmA and sbmC revealed that TraM contacted the DNA within a region previously delineated by DNase I footprinting. Hydroxyl Radical 0-16 androgen receptor Homo sapiens 40-44 11875064-5 2002 Hydroxyl radical footprinting of DNA of sbmA and sbmC revealed that TraM contacted the DNA within a region previously delineated by DNase I footprinting. Hydroxyl Radical 0-16 translocation associated membrane protein 1 Homo sapiens 68-72 12515618-1 2002 OBJECTIVE: To examine the relationship between susceptibility to lung cancer among Chinese and genetic polymorphism at nucleotide -463 (G/A) in myeloperoxidase (MPO), an enzyme found in lysosomes of phagocytes and involved in the formation of hydroxyl radicals and activation of various smoking-related carcinogens. Hydroxyl Radical 243-260 myeloperoxidase Homo sapiens 144-159 12515618-1 2002 OBJECTIVE: To examine the relationship between susceptibility to lung cancer among Chinese and genetic polymorphism at nucleotide -463 (G/A) in myeloperoxidase (MPO), an enzyme found in lysosomes of phagocytes and involved in the formation of hydroxyl radicals and activation of various smoking-related carcinogens. Hydroxyl Radical 243-260 myeloperoxidase Homo sapiens 161-164 11929297-5 2002 The formation of hydroxyl and carbon-centered radicals was indicated by electron paramagnetic resonance spectra using alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone or 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide as spin traps. Hydroxyl Radical 17-25 spindlin 1 Homo sapiens 222-226 11926812-4 2002 In this study, we site-specifically modified each of the dsRBMs of PKR"s dsRBD with the hydroxyl radical generator EDTA small middle dotFe and performed cleavage studies on kinase-activating and kinase-inhibiting RNAs. Hydroxyl Radical 88-104 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 67-70 12101082-4 2002 In addition, analysis of the mode of action of IL-1 beta revealed a novel induction of intracellular ROS, including hydrogen peroxide (H(2)O(2)), the superoxide anion (O(2)(-*)) and the hydroxyl radical (*OH). Hydroxyl Radical 186-202 interleukin 1 beta Homo sapiens 47-56 12039009-4 2002 For manganese catalase, the suggested mechanism instead leads to the formation of a hydroxyl radical after the O-O bond of hydrogen peroxide is cleaved. Hydroxyl Radical 84-100 catalase Homo sapiens 14-22 11751890-5 2002 The reduced form of Trx suppresses the serum-free-induced hydroxyl radicals, lipid peroxidation, and apoptosis, indicating that H(2)O(2) is removed by Trx peroxidase. Hydroxyl Radical 58-75 thioredoxin Homo sapiens 20-23 11751890-5 2002 The reduced form of Trx suppresses the serum-free-induced hydroxyl radicals, lipid peroxidation, and apoptosis, indicating that H(2)O(2) is removed by Trx peroxidase. Hydroxyl Radical 58-75 thioredoxin Homo sapiens 151-154 11918852-8 2002 RESULTS: The proliferation of LAK cells induced by interleukin-2 (IL-2) was inhibited by hydroxyl radical from 48 h to 96 h in a dose-dependent fashion and was inhibited to 34.5 % compared with control at 96 h in the concentration of ascorbic acid 400 micromol/L and ferrous sulfate 40 micromol/L. Hydroxyl Radical 89-105 interleukin 2 Homo sapiens 51-64 11882001-0 2002 Development of long-acting dopamine transporter ligands as potential cocaine-abuse therapeutic agents: chiral hydroxyl-containing derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine. Hydroxyl Radical 110-118 solute carrier family 6 member 3 Macaca mulatta 27-47 11958955-7 2002 These results suggest that the aggregation of alpha-synuclein is mediated by the Cu,Zn-SOD/H(2)O(2) system via the generation of hydroxyl radical by the free radical-generating function of the enzyme. Hydroxyl Radical 129-145 synuclein alpha Homo sapiens 46-61 11958955-7 2002 These results suggest that the aggregation of alpha-synuclein is mediated by the Cu,Zn-SOD/H(2)O(2) system via the generation of hydroxyl radical by the free radical-generating function of the enzyme. Hydroxyl Radical 129-145 superoxide dismutase 1 Homo sapiens 87-90 11918852-8 2002 RESULTS: The proliferation of LAK cells induced by interleukin-2 (IL-2) was inhibited by hydroxyl radical from 48 h to 96 h in a dose-dependent fashion and was inhibited to 34.5 % compared with control at 96 h in the concentration of ascorbic acid 400 micromol/L and ferrous sulfate 40 micromol/L. Hydroxyl Radical 89-105 interleukin 2 Homo sapiens 66-70 11918852-19 2002 The growth of LAK cells induced by IL-2 was down-regulated by hydroxyl radical. Hydroxyl Radical 62-78 interleukin 2 Homo sapiens 35-39 11958437-5 2002 Hydrogen peroxide possibly converted to hydroxyl radical by iron due to lower transferrin level might have led to increased serum lipid peroxidation in patients with rheumatoid arthritis. Hydroxyl Radical 40-56 transferrin Homo sapiens 78-89 12014661-3 2002 Myeloperoxidase converts hydrogen peroxide into the selective apoptosis mediator HOCl, which interacts with transformed target cell-derived superoxide anions and generates apoptosis-inducing hydroxyl radicals. Hydroxyl Radical 191-208 myeloperoxidase Homo sapiens 0-15 12014663-5 2002 CYP2E1 inhibitors markedly reduced H2O2 generation with the preservation of CYP2E1 content, markedly decreased in iron and hydroxyl radical formation associated with significant attenuation in cytotoxicity. Hydroxyl Radical 123-139 cytochrome P450 family 2 subfamily E member 1 Sus scrofa 0-6 11742007-4 2002 We have used iron(II)-induced hydroxyl radical cleavage to map Fe(2+) binding sites in PARN. Hydroxyl Radical 30-38 poly(A)-specific ribonuclease Homo sapiens 87-91 11844698-2 2002 Here we demonstrate that hydroxyl radicals generated selectively by photolysis of a photo-Fenton reagent, N,N"-bis(2-hydroperoxy-2-methoxyethyl)-1,4,5,8-naphthaldiimide (NP-III), induce apoptosis in HL-60 (human promyelocytic leukemia) cells involving the activation of caspase-3. Hydroxyl Radical 25-42 caspase 3 Homo sapiens 270-279 11911459-5 2002 All three compounds also inhibited the release of copper ion from protein, and the formation of hydroxyl radicals in the ceruloplasmin/H2O2 system. Hydroxyl Radical 96-113 ceruloplasmin Homo sapiens 121-134 11709584-5 2001 Although these results suggest that the protection of photosynthesis can be realized by reducing either superoxide or H(2)O(2) levels, thereby reducing the possibility of hydroxyl radical formation, the situation is complicated, since elevated APX or GR activity can improve recoveries even when additional SOD activity has no effect. Hydroxyl Radical 171-187 L-ascorbate peroxidase, cytosolic-like Gossypium hirsutum 244-247 11937868-3 2002 The bone mineral idealized as calcium hydroxyapatite, Ca10 (PO4)(6)(OH)2, is a carbonatehydroxyapatite, approximated by the formula: (Ca,X)(10)(PO4,HPO4,CO3)(6)(OH,Y)2, where X are cations (magnesium, sodium, strontium ions) that can substitute for the calcium ions, and Y are anions (chloride or fluoride ions) that can substitute for the hydroxyl group. Hydroxyl Radical 340-348 carbonic anhydrase 10 Homo sapiens 54-58 12028219-10 2002 Reaction of antipyrine with hydroxyl radicals results in the formation of para-hydroxyantipyrine (p-APOH) and ortho-hydroxyantipyrine (o-APOH), where o-APOH is not formed through alternative oxygenetic pathways. Hydroxyl Radical 28-45 apolipoprotein H Homo sapiens 100-104 12028219-10 2002 Reaction of antipyrine with hydroxyl radicals results in the formation of para-hydroxyantipyrine (p-APOH) and ortho-hydroxyantipyrine (o-APOH), where o-APOH is not formed through alternative oxygenetic pathways. Hydroxyl Radical 28-45 apolipoprotein H Homo sapiens 137-141 12028219-10 2002 Reaction of antipyrine with hydroxyl radicals results in the formation of para-hydroxyantipyrine (p-APOH) and ortho-hydroxyantipyrine (o-APOH), where o-APOH is not formed through alternative oxygenetic pathways. Hydroxyl Radical 28-45 apolipoprotein H Homo sapiens 137-141 12038511-7 2002 Based on these data, it is concluded that hydrogen peroxide might be the source of hydroxyl radicals directly oxidizing luminol in the first phase of the LDCL signal, while in the second phase it serves as a substrate of myeloperoxidase in the peroxidation reaction of the luminol. Hydroxyl Radical 83-100 myeloperoxidase Rattus norvegicus 221-236 11728184-2 2001 X-ray crystal structures of complexes of neuraminidase with known five- and six-membered ring inhibitors revealed that potent inhibition of the enzyme is determined by the relative positions of the interacting inhibitor substituents (carboxylate, glycerol, acetamido, hydroxyl) rather than by the absolute position of the central ring. Hydroxyl Radical 268-276 neuraminidase 1 Homo sapiens 41-54 11842105-7 2002 Hydroxyl radical footprinting indicates that Exo1 binds predominantly along the minor groove of flap DNA, downstream of the junction. Hydroxyl Radical 0-16 exonuclease 1 Homo sapiens 45-49 11791932-1 2002 Since the realization of a complement activation capacity by artificial surfaces upon contact with blood, a common belief has evolved that charged nucleophilic surface groups such as amine (-NH2) and hydroxyl (-OH) react with and eventually bind to the internal thioester in complement factor 3 (C3). Hydroxyl Radical 200-208 complement C3 Homo sapiens 275-294 11791932-1 2002 Since the realization of a complement activation capacity by artificial surfaces upon contact with blood, a common belief has evolved that charged nucleophilic surface groups such as amine (-NH2) and hydroxyl (-OH) react with and eventually bind to the internal thioester in complement factor 3 (C3). Hydroxyl Radical 200-208 complement C3 Homo sapiens 296-298 11872643-2 2002 Significant increase of hydroxyl radical levels by day 4 of PB exposure accompanied the accumulation of 8-OHdG in the nucleus and P-450 isoenzymes CYP2B1/2 and CYP3A2 in the cytoplasm of hepatocytes. Hydroxyl Radical 24-40 cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus 147-153 11872643-2 2002 Significant increase of hydroxyl radical levels by day 4 of PB exposure accompanied the accumulation of 8-OHdG in the nucleus and P-450 isoenzymes CYP2B1/2 and CYP3A2 in the cytoplasm of hepatocytes. Hydroxyl Radical 24-40 cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus 160-166 11899098-5 2002 Reactive oxygen species (e.g., superoxide, peroxynitrite, hydrogen peroxide and hydroxyl radical) are all potential reactants capable of initiating DNA single strand breakage, with subsequent activation of the nuclear enzyme poly (ADP ribose) synthetase (PARS), leading to eventual severe energy depletion of the cells, and necrotic-type cell death. Hydroxyl Radical 80-96 poly(ADP-ribose) polymerase 1 Homo sapiens 225-253 11899098-5 2002 Reactive oxygen species (e.g., superoxide, peroxynitrite, hydrogen peroxide and hydroxyl radical) are all potential reactants capable of initiating DNA single strand breakage, with subsequent activation of the nuclear enzyme poly (ADP ribose) synthetase (PARS), leading to eventual severe energy depletion of the cells, and necrotic-type cell death. Hydroxyl Radical 80-96 glutamyl-prolyl-tRNA synthetase 1 Homo sapiens 255-259 11851353-2 2002 Using isolated microsomal membranes exposed to a superoxide and hydroxyl radical generating system, 9-AAP was found to be at least 10-fold more potent than propranolol (and about 50% as potent as vitamin E) in inhibiting lipid peroxidation. Hydroxyl Radical 64-80 serpin family F member 2 Homo sapiens 102-105 11784334-8 2002 PAP cleavage sites differed from those of hK3 and were mainly at P1 = Gln residues or between residues bearing hydroxyl groups. Hydroxyl Radical 111-119 acid phosphatase 3 Homo sapiens 0-3 11750760-4 2001 Additionally, GIF can scavenge the hydroxyl radical efficiently in CytC-VitC radical producing system and its alpha-domain shown more effective potentials than its beta-domain. Hydroxyl Radical 35-51 metallothionein 3 Homo sapiens 14-17 11698338-3 2001 Using 2",7"-dichlorofluorescin diacetate, a dye that fluoresces in the presence of hydrogen peroxide or hydroxyl radicals, we found that prostate specific antigen markedly stimulated reactive oxygen species generation in LNCaP cells. Hydroxyl Radical 104-121 kallikrein related peptidase 3 Homo sapiens 137-162 11735098-5 2001 Furthermore, antipyrine reacts quickly with hydroxyl radicals (10(10)-10(11) L x mol(-1) x s(-1)) to form para- and ortho-hydroxyantipyrine (o-APOH). Hydroxyl Radical 44-61 apolipoprotein H Homo sapiens 143-147 11780642-3 2001 Here we study structural changes of the ribosome related to EF-G binding and translocation by monitoring the accessibility of ribosomal RNA (rRNA) for chemical modification by dimethyl sulfate or cleavage by hydroxyl radicals generated by Fe(II)-EDTA. Hydroxyl Radical 208-225 G elongation factor mitochondrial 1 Homo sapiens 60-64 11595385-0 2001 The consequences of hydroxyl radical formation on the stoichiometry and kinetics of ferrous iron oxidation by human apoferritin. Hydroxyl Radical 20-36 ferritin heavy chain 1 Homo sapiens 116-127 11595385-3 2001 Hydroxyl radical formation was found to affect both the stoichiometry and kinetics of Fe(II) oxidation by apoferritin. Hydroxyl Radical 0-16 ferritin heavy chain 1 Homo sapiens 106-117 11765787-3 2001 The time-dependent SERS spectra of MTPP (M = Ag, Cu) on hydroxyl-modified Ag colloid were recorded and dramatic change on SERS spectra was observed. Hydroxyl Radical 56-64 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 19-23 11594765-3 2001 In this study murine macrophage like cell line RAW-264 overexpressing TRAP was shown to produce elevated levels of hydroxyl radicals compared to parental cells. Hydroxyl Radical 115-132 acid phosphatase 5, tartrate resistant Mus musculus 70-74 11595385-2 2001 In the present study, hydroxyl radical formation during Fe(II) oxidation by apoferritin was found to be contingent on the "ferroxidase" activity (i.e., H subunit composition) exhibited by apoferritin. Hydroxyl Radical 22-38 ferritin heavy chain 1 Homo sapiens 76-87 11595385-2 2001 In the present study, hydroxyl radical formation during Fe(II) oxidation by apoferritin was found to be contingent on the "ferroxidase" activity (i.e., H subunit composition) exhibited by apoferritin. Hydroxyl Radical 22-38 ferritin heavy chain 1 Homo sapiens 188-199 11686326-0 2001 Oxidation of beta2-glycoprotein I (beta2GPI) by the hydroxyl radical alters phospholipid binding and modulates recognition by anti-beta2GPI autoantibodies. Hydroxyl Radical 52-68 apolipoprotein H Homo sapiens 13-33 11710060-2 2001 In these samples, C-6 position hydroxyls in the anhydroglucose units (AGU) along the cellulose chain were selectively substituted by the hydrophobic triphenylmethyl groups, but C-2 and -3 position hydroxyls remained in 6TC or were substituted completely by O-acetyls in 2,3Ac6TC. Hydroxyl Radical 31-40 complement C6 Homo sapiens 18-21 11710060-2 2001 In these samples, C-6 position hydroxyls in the anhydroglucose units (AGU) along the cellulose chain were selectively substituted by the hydrophobic triphenylmethyl groups, but C-2 and -3 position hydroxyls remained in 6TC or were substituted completely by O-acetyls in 2,3Ac6TC. Hydroxyl Radical 197-206 complement C2 Homo sapiens 177-187 11479320-6 2001 Hydroxyl radical footprinting demonstrates that the RBD protects a region of the RNA duplex around the editing site, suggesting a significant role for the RBD in identifying potential ADAR2 editing sites. Hydroxyl Radical 0-16 adenosine deaminase RNA specific B1 Homo sapiens 184-189 11686326-0 2001 Oxidation of beta2-glycoprotein I (beta2GPI) by the hydroxyl radical alters phospholipid binding and modulates recognition by anti-beta2GPI autoantibodies. Hydroxyl Radical 52-68 apolipoprotein H Homo sapiens 35-43 11686326-0 2001 Oxidation of beta2-glycoprotein I (beta2GPI) by the hydroxyl radical alters phospholipid binding and modulates recognition by anti-beta2GPI autoantibodies. Hydroxyl Radical 52-68 apolipoprotein H Homo sapiens 131-139 11686326-1 2001 We investigated whether beta2-glycoprotein I (beta2GPI), the key antigen in the antiphospholipid syndrome, is susceptible to oxidative modifications by the hydroxyl radical (*OH) that may influence its lipid-binding and antigenic properties. Hydroxyl Radical 156-172 apolipoprotein H Homo sapiens 24-44 11686326-1 2001 We investigated whether beta2-glycoprotein I (beta2GPI), the key antigen in the antiphospholipid syndrome, is susceptible to oxidative modifications by the hydroxyl radical (*OH) that may influence its lipid-binding and antigenic properties. Hydroxyl Radical 156-172 apolipoprotein H Homo sapiens 46-54 11511974-1 2001 Peroxynitrite and hydroxyl radicals are potent initiators of DNA single-strand breakage, which is an obligatory stimulus for the activation of the nuclear enzyme poly(ADP ribose) polymerase (PARP). Hydroxyl Radical 18-35 poly(ADP-ribose) polymerase 1 Homo sapiens 162-189 11680849-4 2001 In this study, we define the binding site of SBP2 on six different SECIS RNAs using enzymatic and hydroxyl radical footprinting, gel mobility shift analysis, and phosphate-ethylation binding interference. Hydroxyl Radical 98-114 SECIS binding protein 2 Homo sapiens 45-49 11546558-4 2001 In our previous study, the contribution of multidrug resistance protein 2 for biliary excretion of taurine-conjugated bile acid sulfates depended on the numbers of hydroxyl residue. Hydroxyl Radical 164-172 ATP binding cassette subfamily B member 4 Rattus norvegicus 43-73 11525764-10 2001 Reactive oxygen species (e.g., superoxide, peroxynitrite, hydroxyl radical and hydrogen peroxide) are all potential reactants capable of initiating DNA single-strand breakage, with subsequent activation of the nuclear enzyme poly (ADP-ribose) synthetase (PARS), leading to eventual severe energy depletion of the cells, and necrotic-type cell death. Hydroxyl Radical 58-74 poly(ADP-ribose) polymerase 1 Homo sapiens 225-253 11525764-10 2001 Reactive oxygen species (e.g., superoxide, peroxynitrite, hydroxyl radical and hydrogen peroxide) are all potential reactants capable of initiating DNA single-strand breakage, with subsequent activation of the nuclear enzyme poly (ADP-ribose) synthetase (PARS), leading to eventual severe energy depletion of the cells, and necrotic-type cell death. Hydroxyl Radical 58-74 glutamyl-prolyl-tRNA synthetase 1 Homo sapiens 255-259 11525742-3 2001 Sod and Cat constitute an evolutionary conserved ROS defense system against superoxide; Sod converts superoxide anions to H(2)O(2), and Cat prevents free hydroxyl radical formation by breaking down H(2)O(2) into oxygen and water. Hydroxyl Radical 154-162 Superoxide dismutase 1 Drosophila melanogaster 0-3 11525742-3 2001 Sod and Cat constitute an evolutionary conserved ROS defense system against superoxide; Sod converts superoxide anions to H(2)O(2), and Cat prevents free hydroxyl radical formation by breaking down H(2)O(2) into oxygen and water. Hydroxyl Radical 154-162 Superoxide dismutase 1 Drosophila melanogaster 88-91 11511974-1 2001 Peroxynitrite and hydroxyl radicals are potent initiators of DNA single-strand breakage, which is an obligatory stimulus for the activation of the nuclear enzyme poly(ADP ribose) polymerase (PARP). Hydroxyl Radical 18-35 poly(ADP-ribose) polymerase 1 Homo sapiens 191-195 11512146-7 2001 We conclude from these results that CS2 can induce the phenanthroline chemiluminescence system to generate hydroxyl radicals and advance the peak time, and that thiourea can inhibit the effect. Hydroxyl Radical 107-124 chorionic somatomammotropin hormone 2 Homo sapiens 36-39 11488401-0 2001 Inhibition of brain monoamine oxidase activity by the generation of hydroxyl radicals: potential implications in relation to oxidative stress. Hydroxyl Radical 68-85 monoamine oxidase A Rattus norvegicus 20-37 11488401-3 2001 In this study we investigated the potential effects of the production of hydroxyl radicals (*OH) on MAO-A and MAO-B activities using mitochondrial preparations obtained from rat brain. Hydroxyl Radical 73-90 monoamine oxidase A Rattus norvegicus 100-105 11488401-3 2001 In this study we investigated the potential effects of the production of hydroxyl radicals (*OH) on MAO-A and MAO-B activities using mitochondrial preparations obtained from rat brain. Hydroxyl Radical 73-90 monoamine oxidase B Rattus norvegicus 110-115 11474839-7 2001 Many of the SOD1 mutations associated with FALS appear to increase the likelihood that the enzyme will perform either one of these potentially harmful functions resulting in increased hydroxyl radical formation or the addition of nitro groups to tyrosine residues within cellular proteins. Hydroxyl Radical 184-200 superoxide dismutase 1 Homo sapiens 12-16 11512146-1 2001 We investigated the effects of carbon disulphide (CS2) on hydroxyl radical generation using the phenanthroline chemiluminescence system. Hydroxyl Radical 58-74 chorionic somatomammotropin hormone 2 Homo sapiens 50-53 11380478-1 2001 Hydroxyl radical formation catalysed by non-transferrin-bound iron (NTBI) might contribute to transplantation-related complications. Hydroxyl Radical 0-16 transferrin Homo sapiens 44-55 11409888-6 2001 The results showed that CTGF was induced by reactive oxygen species such as hydrogen peroxide and hydroxyl radicals. Hydroxyl Radical 98-115 cellular communication network factor 2 Homo sapiens 24-28 11331361-9 2001 Catalase and pyruvate were each found to inhibit the production of hydroxyl radicals generated by cysteine autoxidation. Hydroxyl Radical 67-84 catalase Rattus norvegicus 0-8 11678602-4 2001 Catalase, a scavenger of H2O2, sodium formate and aspirin, scavengers of hydroxyl radical (*OH), also inhibited the increased tyrosine phosphorylation induced by Cr (VI). Hydroxyl Radical 73-89 catalase Homo sapiens 0-8 11254205-3 2001 In the present study, the process of proton transfer between hydroxyl and imidazole groups, a model of the crucial step in the hydrolysis of RNA by the enzymes of the RNase A family, is investigated at the quantum mechanical level of density functional theory and perturbation theory at the MP2 level. Hydroxyl Radical 61-69 ribonuclease A family member 1, pancreatic Homo sapiens 167-174 11335104-0 2001 Effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on nitric oxide-induced hydroxyl radical generation in the rat heart. Hydroxyl Radical 112-128 3-hydroxy-3-methylglutaryl-CoA reductase Rattus norvegicus 39-86 11335104-1 2001 We examined the effect of fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, on the production of hydroxyl radical (*OH) generation via nitric oxide synthase (NOS) activation by an in vivo microdialysis technique. Hydroxyl Radical 131-147 3-hydroxy-3-methylglutaryl-CoA reductase Rattus norvegicus 41-98 11207678-3 2001 We have examined the effects of a generator of hydroxyl radicals (g*OH: 2,2"-azo-bis(2-amidinopropane)) and hydrogen peroxide (H2O2) on ACE using an in vitro approach. Hydroxyl Radical 47-64 angiotensin I converting enzyme Homo sapiens 136-139 11207678-5 2001 The generator of hydroxyl radicals inactivated ACE in a time (2-6 h)- and concentration (0.3-3 mmol/L)-dependent manner at 37 degrees C. When ACE was coincubated for 4 h with g*OH (3 mmol/L), its activity decreased by 70%. Hydroxyl Radical 17-34 angiotensin I converting enzyme Homo sapiens 47-50 11207678-5 2001 The generator of hydroxyl radicals inactivated ACE in a time (2-6 h)- and concentration (0.3-3 mmol/L)-dependent manner at 37 degrees C. When ACE was coincubated for 4 h with g*OH (3 mmol/L), its activity decreased by 70%. Hydroxyl Radical 17-34 angiotensin I converting enzyme Homo sapiens 142-145 11257465-6 2001 We found that in a dose-dependent manner fibrinogen inhibited superoxide generation (pyrogallol and xanthine-xanthine oxidase reactions), ferrous ion oxidation and hydroxyl radical dependent degradation (of deoxyribose). Hydroxyl Radical 164-180 fibrinogen beta chain Homo sapiens 41-51 11357419-2 2001 Blocking of catalytically active groups by specific reagents, dependence of the enzyme activity on pH, enthalpy of ionization of pK1 and pK2, the enzyme photoinactivation allowed to make a conclusion that imidasole and hydroxyl groups take part in lipoxygenase catalytic cycle. Hydroxyl Radical 219-227 LOC543232 Triticum aestivum 248-260 11277917-9 2001 Catalase significantly inhibited the oxidation, implying the participation of hydroxyl radical in the reaction, but superoxide dismutase stimulated the oxidation, probably due to its radical formation activity. Hydroxyl Radical 78-94 catalase Homo sapiens 0-8 11315194-0 2001 Hydrogen peroxide and hydroxyl radical involvement in the activation of caspase-3 in chemically induced apoptosis of HL-60 cells. Hydroxyl Radical 22-38 caspase 3 Homo sapiens 72-81 11315194-3 2001 These results suggest that hydrogen peroxide and the hydroxyl radical are common mediators of caspase-3 activation caused by these chemicals, with apparently different functional mechanisms. Hydroxyl Radical 53-69 caspase 3 Homo sapiens 94-103 11321508-6 2001 Mannitol and glycerol, known scavengers of hydroxyl radical, arrest the elevation in lipid peroxidation of erythrocytes after LPS treatment. Hydroxyl Radical 43-59 interferon regulatory factor 6 Homo sapiens 126-129 11171943-10 2001 ROS (e.g., superoxide, peroxynitrite, hydroxyl radical, and hydrogen peroxide) are all potential reactants capable of initiating DNA single-strand breakage, with subsequent activation of the nuclear enzyme poly(ADP-ribose) synthetase, leading to eventual severe energy depletion of the cells and necrotic-type cell death. Hydroxyl Radical 38-54 poly(ADP-ribose) polymerase 1 Homo sapiens 206-233 11254205-3 2001 In the present study, the process of proton transfer between hydroxyl and imidazole groups, a model of the crucial step in the hydrolysis of RNA by the enzymes of the RNase A family, is investigated at the quantum mechanical level of density functional theory and perturbation theory at the MP2 level. Hydroxyl Radical 61-69 tryptase pseudogene 1 Homo sapiens 291-294 11314772-0 2001 The central catechol-O-methyltransferase inhibitor tolcapone increases striatal hydroxyl radical production in L-DOPA/carbidopa treated rats. Hydroxyl Radical 80-96 catechol-O-methyltransferase Rattus norvegicus 12-40 11175902-4 2001 Hydroxyl radical footprinting demonstrates that assembly with the CBP2 protein cofactor chases the RNA from the collapsed state to the native state. Hydroxyl Radical 0-16 serpin family H member 1 Homo sapiens 66-70 11163759-5 2001 Moreover, we found that hydroxyl radical-induced apoptosis in telomerase-expressing and control fibroblasts was caspase-3 independent. Hydroxyl Radical 24-40 caspase 3 Homo sapiens 112-121 11330830-5 2001 The rate constant describing EGCG reaction against hydroxyl radical was 4.22+/-0.07 x 10(10) M(-1) x sec(-1), which was comparable to those of Trolox and alpha-tocopherol, respectively. Hydroxyl Radical 51-67 secretory blood group 1, pseudogene Homo sapiens 101-107 11133518-6 2001 In an in vitro study utilizing glomerular epithelial cells (GEC), CYP inhibitors also markedly prevented the PAN-induced increase in the catalytic iron and hydroxyl radical formation accompanied by significant protection against PAN-induced cytotoxicity. Hydroxyl Radical 156-164 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 66-69 11161607-6 2001 SOD2(+/-) mice also showed an increased production of "hydroxyl" radicals after malonate injection measured with the salicylate hydroxyl radical trapping method. Hydroxyl Radical 55-73 superoxide dismutase 2, mitochondrial Mus musculus 0-4 11314772-2 2001 To investigate this hypothesis, the acute effects of two doses of the systemically administered COMT inhibitors entacapone (peripheral) and tolcapone (peripheral and central) on the extracellular formation of hydroxyl radicals in vivo following treatment with L-DOPA and the AADC inhibitor carbidopa were examined. Hydroxyl Radical 209-226 catechol-O-methyltransferase Rattus norvegicus 96-100 11314772-13 2001 We conclude that the increase in hydroxyl radical formation is likely to result from an increased rate of monoamine oxidase-mediated and non-enzymatic (autoxidation) dopamine metabolism following increased central availability caused by reduction in COMT-mediated metabolism. Hydroxyl Radical 33-49 catechol-O-methyltransferase Rattus norvegicus 250-254 11023998-3 2000 Similar to nuclear redox factor-1 (Ref-1), mRNA of human neuronal nitric oxide synthase (hNOS1) was maximally up-regulated within 2 h after oxidative stress and down-regulated by NO/GSNO and hydroxyl radical (OH) scavenger. Hydroxyl Radical 191-207 nitric oxide synthase 1 Homo sapiens 89-94 11865975-7 2001 Hydroxyl radical levels generated by the quinone-containing agents were low in BCL-2-expressing JB6 cells compared to control Neo cells. Hydroxyl Radical 0-16 BCL2 apoptosis regulator Homo sapiens 79-84 11125747-3 2000 RESULTS: DAT patients with the apoE4 phenotype showed higher hydroxyl radical levels than DAT patients without the apoE4 phenotype or controls. Hydroxyl Radical 61-77 apolipoprotein E Homo sapiens 31-36 11113563-5 2000 The results suggested that the enhanced oxidative damage of macromolecules is mediated in the Cu,Zn-SOD mutants and hydrogen peroxide system via the generation of hydroxyl radicals by a combination of the higher free radical-generating activities of mutants and a Fenton-like reaction of copper ions released from oxidatively damaged Cu,Zn-SODs. Hydroxyl Radical 163-180 superoxide dismutase 1 Homo sapiens 100-103 11032742-3 2000 In this report, we present evidence that human thioredoxin is a powerful singlet oxygen quencher and hydroxyl radical scavenger. Hydroxyl Radical 101-117 thioredoxin Homo sapiens 47-58 11395328-5 2000 The present study has applied a simple and precise procedure for the study of hydroxyl radical scavenging activity by Co(II)/EDTA-induced luminol chemiluminescence, and this was assessed by DPPH* free radical scavenging. Hydroxyl Radical 78-94 mitochondrially encoded cytochrome c oxidase II Homo sapiens 118-124 11020293-9 2000 Specifically, in the CBN series the removal of the phenolic hydroxyl decreases binding affinity to both the CB1 and CB2 receptors, whereas in the THC series, CB1 affinity is selectively reduced. Hydroxyl Radical 60-68 cannabinoid receptor 1 Homo sapiens 108-111 11020293-9 2000 Specifically, in the CBN series the removal of the phenolic hydroxyl decreases binding affinity to both the CB1 and CB2 receptors, whereas in the THC series, CB1 affinity is selectively reduced. Hydroxyl Radical 60-68 cannabinoid receptor 2 Homo sapiens 116-119 11020293-11 2000 Generally, high affinity for the CB2 receptor was found in analogues when the phenolic hydroxyl was present. Hydroxyl Radical 87-95 cannabinoid receptor 2 Homo sapiens 33-36 10940582-3 2000 The results indicated that the cytotoxicity was notably decreased by structural changes, i.e. by modulation of the planarity caused by the introduction of hydroxyl group at C-8 and concomitant saturation of double bond between N-C8 in protoberberine molecules. Hydroxyl Radical 155-163 homeobox C8 Homo sapiens 173-176 11033414-1 2000 Oxidation of 1-O-hexadec-1"-enyl-arachidonoyl glycerophosphocholine (16:0p/20:4-GPC) by hydroxyl radical generated from Cu(II)/H(2)O(2) was found to yield major products corresponding to free carboxylic acids of 5-hydroxyeicosatetraenoic acid and several 5, 12-dihydroxyeicosatetraenoic acid. Hydroxyl Radical 88-104 glycophorin C (Gerbich blood group) Homo sapiens 80-83 10942736-0 2000 The role of hydroxyl radical as a messenger in Cr(VI)-induced p53 activation. Hydroxyl Radical 12-28 tumor protein p53 Homo sapiens 62-65 10963730-6 2000 H(2)O(2) (30 microM)-induced phasic contraction could be abolished by catalase (800 U/ml), but not affected by SOD (150 U/ml), DMSO (5 mM) and apyrase (5 U/ml), suggesting no involvement of O(2)(-), hydroxyl free radicals and ATP release. Hydroxyl Radical 199-207 catalase Rattus norvegicus 70-78 11025198-3 2000 Using a new highly sensitive technique that employs a fluorescamine-derivatized nitroxide, we show that low levels of NADPH-cytochrome P450 reductase (4.25 microg/ml) catalyze the production of hydroxyl radicals at very low, clinically relevant AZQ concentrations. Hydroxyl Radical 194-211 cytochrome p450 oxidoreductase Homo sapiens 118-149 11465080-2 2000 The UDP-glucuronosyltransferase (UGT) family catalyzes the glucuronidation of the glycosyl group of a nucleotide sugar to an acceptor compound (aglycone) at a nucleophilic functional group of oxygen (eg, hydroxyl or carboxylic acid groups), nitrogen (eg, amines), sulfur (eg, thiols), and carbon, with the formation of a beta-D-glucuronide product. Hydroxyl Radical 204-212 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 4-31 11465080-2 2000 The UDP-glucuronosyltransferase (UGT) family catalyzes the glucuronidation of the glycosyl group of a nucleotide sugar to an acceptor compound (aglycone) at a nucleophilic functional group of oxygen (eg, hydroxyl or carboxylic acid groups), nitrogen (eg, amines), sulfur (eg, thiols), and carbon, with the formation of a beta-D-glucuronide product. Hydroxyl Radical 204-212 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 33-36 10962103-0 2000 Nitric oxide protects nitric oxide synthase function from hydroxyl radical-induced inhibition. Hydroxyl Radical 58-74 nitric oxide synthase 2 Homo sapiens 22-43 10962128-3 2000 The results show that hydroxyl radicals generated by the Fenton reaction induced apoptosis in cerebellar granule cells, which was associated with the decrease in the Bcl-2 mRNA level and the increase in the protein levels of the transcription factors Fos and Jun. Hydroxyl Radical 22-39 BCL2, apoptosis regulator Rattus norvegicus 166-171 10962128-3 2000 The results show that hydroxyl radicals generated by the Fenton reaction induced apoptosis in cerebellar granule cells, which was associated with the decrease in the Bcl-2 mRNA level and the increase in the protein levels of the transcription factors Fos and Jun. Hydroxyl Radical 22-39 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 251-254 10921897-3 2000 When probed with hydroxyl radicals, ssDNA-RAD52 complexes exhibit a four-nucleotide repeat hypersensitivity pattern. Hydroxyl Radical 17-34 RAD52 homolog, DNA repair protein Homo sapiens 42-47 10874621-3 2000 Rate constants of the reactions between ozone and simazine and hydroxyl radical and simazine were found to be 8.7 M-1s-1 and 2.1 x 10(9) M-1s-1, respectively. Hydroxyl Radical 63-79 myoregulin Homo sapiens 114-126 10898600-1 2000 Exposure of individual histone proteins (H1, H2A, H2B, H3, or H4) and histone octamers (consisting of two molecules each of H2A, H2B, H3, and H4) to hydroxyl radicals, generated by gamma-irradiation, in the presence of O(2) generates protein-bound hydroperoxides in a dose-dependent fashion; this is in accord with previous studies with other proteins. Hydroxyl Radical 149-166 histone H2B type 2-E Bos taurus 129-144 10874621-3 2000 Rate constants of the reactions between ozone and simazine and hydroxyl radical and simazine were found to be 8.7 M-1s-1 and 2.1 x 10(9) M-1s-1, respectively. Hydroxyl Radical 63-79 tumor associated calcium signal transducer 2 Homo sapiens 114-120 10801319-9 2000 A low barrier hydrogen bond between the 4"-hydroxyl group of the sugar and O(gamma) of Ser 132 facilitates proton transfer from the sugar 4"-hydroxyl group to O(eta) of Tyr 157. Hydroxyl Radical 43-51 endothelin receptor type A Homo sapiens 161-164 10886557-13 2000 CONCLUSION: Elevated levels of TGF-beta1 derived from glomerular or extraglomerular sources are capable of increasing glomerular Palb via superoxide and hydroxyl radicals and may lead to proteinuria in vivo. Hydroxyl Radical 153-170 transforming growth factor, beta 1 Rattus norvegicus 31-40 10856972-5 2000 Furthermore, they suggested the possibility that it correlates to copper accumulation due to the Atp7b gene mutation, because ionizing radiation-induced hydroxyl radicals might act in concert with copper-induced hydroxyl radicals. Hydroxyl Radical 153-170 ATPase copper transporting beta Rattus norvegicus 97-102 10856972-5 2000 Furthermore, they suggested the possibility that it correlates to copper accumulation due to the Atp7b gene mutation, because ionizing radiation-induced hydroxyl radicals might act in concert with copper-induced hydroxyl radicals. Hydroxyl Radical 212-229 ATPase copper transporting beta Rattus norvegicus 97-102 10929380-2 2000 Under the condition of low scavenging capacity existing in the irradiated DNA solution, SSB and alpha DSB were mainly induced by hydroxyl radicals (.OH). Hydroxyl Radical 129-146 small RNA binding exonuclease protection factor La Homo sapiens 88-91 10886557-0 2000 Transforming growth factor-beta1 increases albumin permeability of isolated rat glomeruli via hydroxyl radicals. Hydroxyl Radical 94-111 transforming growth factor, beta 1 Rattus norvegicus 0-32 10677220-11 2000 Hydroxyl radical footprints of the wild-type yOgg1 show strong protection of six nucleotides centered around the Pr lesion in the damaged strand. Hydroxyl Radical 0-16 8-oxoguanine glycosylase OGG1 Saccharomyces cerevisiae S288C 45-50 10725125-4 2000 Hydroxyl radicals destabilized myosin, lowering its denaturation temperature by up to 4 degrees C. Oxidized myosin also produced a new thermal transition in the 60-80 degrees C temperature range, which could be attributed to the formation of disulfide-stabilized polymers. Hydroxyl Radical 0-17 myosin, heavy chain 15 Gallus gallus 31-37 10799480-0 2000 Mitochondrial aconitase is a source of hydroxyl radical. Hydroxyl Radical 39-55 aconitase 2 Homo sapiens 0-23 10799480-5 2000 Consequently, the inactivation of m-aconitase by superoxide may increase the formation of hydroxyl radical ((*)OH) through the Fenton reaction in mitochondria. Hydroxyl Radical 90-106 aconitase 2 Homo sapiens 34-45 10839124-0 2000 myo-Inositol 4,6-carbonate: an easily prepared small molecule with three syn-axial hydroxyl groups. Hydroxyl Radical 83-91 synemin Homo sapiens 73-76 11232597-4 2000 Our laboratory demonstrated that hydroxyl radicals also activate the cardiac Ca2+-release channel activity, likely through the modification of sulfhydryl groups of the RyR. Hydroxyl Radical 33-50 ryanodine receptor 1 Homo sapiens 168-171 10644050-0 2000 Protective effect of erythropoietin on the oxidative damage of erythrocyte membrane by hydroxyl radical. Hydroxyl Radical 87-103 erythropoietin Homo sapiens 21-35 10727774-4 2000 Hydroxyl radical scavengers such as azide and mannitol inhibited the fragmentation of ceruloplasmin. Hydroxyl Radical 0-16 ceruloplasmin Homo sapiens 86-99 10727774-5 2000 The deoxyribose assay showed that hydroxyl radicals were generated in the reaction of ceruloplasmin with H2O2. Hydroxyl Radical 34-51 ceruloplasmin Homo sapiens 86-99 10727774-9 2000 These results suggest that the fragmentation of ceruloplasmin induced by H2O2 is due to hydroxyl radicals formed by a copper-dependent Fenton-like reaction. Hydroxyl Radical 88-105 ceruloplasmin Homo sapiens 48-61 10706389-5 2000 In addition, linoleic acid peroxidation initiated by hydroxyl radicals was decreased by 4-HPR to the same extent as by vitamin E. Hydroxyl Radical 53-70 haptoglobin-related protein Homo sapiens 90-93 11138458-10 2000 Cyclic voltammetry revealed that the oxidation-reduction process of ADR was not electrochemically reversible and therefore the oxidation potential could not be determined accurately; however its value should be between 0.23 and 0.78 V. Analysis of the photooxidative process revealed that it was not mediated by the formation of singlet oxygen, superoxide anion radicals, hydrogen peroxide or hydroxyl radicals, and it is suggested that ADR was oxidized directly by the excited triplet riboflavin. Hydroxyl Radical 393-410 aldo-keto reductase family 1 member B Homo sapiens 68-71 10665453-1 2000 The role of hydroxyl radicals on the degradation of lignins during a cellulosic pulp bleaching process including a photocatalytic stage, was assessed using peroxyformic acid lignins EL1 and REL1 and two phenolic niphenyl lignin models 1 and 2. Hydroxyl Radical 12-29 erythrocyte membrane protein band 4.1 Homo sapiens 182-185 10639274-10 1999 These results support the hypothesis that the spatial relationship between the carboxylic acid and allylic hydroxyl functions is crucial for high binding affinity with BLTR. Hydroxyl Radical 107-115 leukotriene B4 receptor Homo sapiens 168-172 10580136-1 1999 Many eukaryotic proteins contain O-linked N-acetylglucosamine (O-GlcNAc) on their serine and threonine side chain hydroxyls. Hydroxyl Radical 114-123 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 63-71 10611419-9 1999 The results indicate that the exposure of rat thymocytes to H(2)O(2) at micromolar concentrations increases annexin V binding to cell membranes in a Ca(2+)-dependent manner, suggesting the possibility that the oxidative stress caused by H(2)O(2) (and/or hydroxyl radicals) induces apoptosis via increasing [Ca(2+)](i). Hydroxyl Radical 254-271 annexin A5 Rattus norvegicus 108-117 10607865-0 1999 Involvement of the serotonin transporter in the formation of hydroxyl radicals induced by 3,4-methylenedioxymethamphetamine. Hydroxyl Radical 61-78 solute carrier family 6 member 4 Homo sapiens 19-40 10574920-0 1999 Evidence against the generation of free hydroxyl radicals from the interaction of copper,zinc-superoxide dismutase and hydrogen peroxide. Hydroxyl Radical 40-57 superoxide dismutase 1 Homo sapiens 82-114 10564779-2 1999 Hydroxyl radical scavengers such as sodium azide, formate and mannitol protected the fragmentation of Cu,Zn-SOD. Hydroxyl Radical 0-16 superoxide dismutase 1 Homo sapiens 108-111 10480908-5 1999 We have used hydroxyl radical footprinting, missing nucleoside, and methylation interference experiments to investigate the structure of the complex of the DNA binding domain of Mac1 (called here Mac1(t)) with the two CuRE sites found in the yeast CTR1 promoter. Hydroxyl Radical 13-29 Mac1p Saccharomyces cerevisiae S288C 178-182 10529245-7 1999 We now report that while hypochlorite and hydroxyl radical both modify amino acid residues on alpha 2M, only hypochlorite can abolish the ability of alpha 2M to inhibit proteinases. Hydroxyl Radical 42-58 alpha-2-macroglobulin Homo sapiens 94-102 10554886-2 1999 The synergistic effect of YC-1 and H2O2 on platelet aggregation and increases of cGMP were almost completely prevented by catalase and a selective soluble guanylate cyclase inhibitor (1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), or partially attenuated by the hydroxyl radical scavenger mannitol. Hydroxyl Radical 266-282 RNA binding motif single stranded interacting protein 1 Homo sapiens 26-39 10627995-2 1999 LDL-oxidation by peroxynitrite or the simultaneous action of nitrogen monoxide and superoxide, produced by morpholino-sydnonimine (SIN-1) is considerably enhanced by typical hydroxyl-radical scavengers such as formate or mannitol and by glucose. Hydroxyl Radical 174-190 MAPK associated protein 1 Homo sapiens 131-136 10498032-5 1999 Apparently introduction of a 12alpha-hydroxyl group abolishes the capability of 3alpha-sterol 14 to activate the transcription of the LDL receptor promoter. Hydroxyl Radical 37-45 low-density lipoprotein receptor Cricetulus griseus 134-146 10556560-2 1999 The in vitro production of the cytotoxic hydroxyl radical (*OH) was recorded during the autoxidation of salsolinol (SAL) and salsolinol-1-carboxylic acid (SAL-1C), but not when these two catecholic TIQs were oxidized by tyrosinase. Hydroxyl Radical 41-57 tyrosinase Homo sapiens 220-230 18967651-4 1999 The ratio of amount of dsDNA immobilized on hydroxyl-terminated SAMs to that on carboxyl-terminated SAMs and to that on amino-terminated SAMs is (3-3.5): (1-1.5): 1. Hydroxyl Radical 44-52 methionine adenosyltransferase 1A Homo sapiens 64-68 10470745-13 1999 At pHo 7.0, IFN-gamma-induced increases in permeability were ameliorated by addition of the following agents: 2-phenyl-4,4,5,5- tetramethylimidazoline-1-oxyl-3-oxide (a NO* scavenger), N(G)-monomethyl-L-arginine (a iNOS inhibitor), dimethyl sulfoxide (a hydroxyl radical scavenger), and ascorbate (a peroxynitrous acid scavenger). Hydroxyl Radical 254-270 interferon gamma Homo sapiens 12-21 10470745-14 1999 CONCLUSION: Mild acidosis augments IFN-gamma-induced intestinal epithelial hyperpermeability and ATP depletion, possibly by fostering the formation of peroxynitrous acid and/or hydroxyl radical. Hydroxyl Radical 177-193 interferon gamma Homo sapiens 35-44 10462040-3 1999 IL-8 induction by TNF-alpha was redox sensitive, as indicated by electron spin resonance analysis and inhibition with membrane permeable hydroxyl scavengers. Hydroxyl Radical 137-145 C-X-C motif chemokine ligand 8 Homo sapiens 0-4 10462040-3 1999 IL-8 induction by TNF-alpha was redox sensitive, as indicated by electron spin resonance analysis and inhibition with membrane permeable hydroxyl scavengers. Hydroxyl Radical 137-145 tumor necrosis factor Homo sapiens 18-27 18967651-5 1999 The dsDNA immobilized covalently on hydroxyl-terminated SAMs accounts for 82.8-87.6% of its total surface amount (including small amount of dsDNA adsorbed). Hydroxyl Radical 36-44 methionine adenosyltransferase 1A Homo sapiens 56-60 10440583-2 1999 TNF-alpha stimulated macrophages generated hydroxyl (*OH) and superoxide anion (O2*-) radicals. Hydroxyl Radical 43-51 tumor necrosis factor Homo sapiens 0-9 11228746-7 1999 TNF cytotoxicity, however, was potentiated by superoxide radical quenchers and suppressed by hydroxyl radical and lipid peroxide quenchers. Hydroxyl Radical 93-109 tumor necrosis factor Homo sapiens 0-3 11228746-8 1999 Overall, these results suggest that hydroxyl radicals mediate TNF-induced apoptosis but not activation of NF-kappa B, AP-1, and JNK; superoxide radicals mediate NF-kappa B and JNK activation but potentiate apoptosis; and lipid peroxides are required for all the signals induced by TNF. Hydroxyl Radical 36-53 tumor necrosis factor Homo sapiens 62-65 10336569-1 1999 The widely used sodium channel blocker tetrodotoxin (TTX) is a compound that has six hydroxyl residues at the C-4, C-6, C-8, C-9, C-10, and C-11 positions in addition to a guanidinium group, which is positively charged in biological pH range. Hydroxyl Radical 85-93 complement C4A Rattus norvegicus 110-113 10439394-4 1999 The involvement of the LexA-controlled RuvAB and RecA proteins with the RecG and RecBCD proteins in metabolism and cell viability implies that DNA double-strand breaks (DSB), and thus hydroxyl radicals that normally generate this type of damage, are produced in Pi-starved cells. Hydroxyl Radical 184-201 DNA repair system Escherichia coli 23-27 10540966-11 1999 EP, by scavenging the hydroxyl radicals produced during interaction of PHX with red blood cells, protects the erythrocytes from oxidative attack. Hydroxyl Radical 22-39 erythropoietin Homo sapiens 0-2 10501546-6 1999 Molecular modeling indicated that the hydrophobic interaction between the side chains of alanine-23 of alpha(t1) and leucine-55 of the beta1 subunit could be disrupted by the introduction of a hydroxyl group. Hydroxyl Radical 193-201 interleukin 1 receptor like 1 Homo sapiens 103-111 10501546-6 1999 Molecular modeling indicated that the hydrophobic interaction between the side chains of alanine-23 of alpha(t1) and leucine-55 of the beta1 subunit could be disrupted by the introduction of a hydroxyl group. Hydroxyl Radical 193-201 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 135-140 10489120-6 1999 SIN-1, on the other hand, generates NO and the superoxide anion which, in turn, generated peroxynitrite which was then converted to the hydroxyl radical. Hydroxyl Radical 136-152 MAPK associated protein 1 Homo sapiens 0-5 10489120-11 1999 SOD, a superoxide scavenger, decreased GSA synthesis by 20%, and catalase inhibited GSA synthesis only by 12%; DMSO, a hydroxyl radical scavenger completely inhibited GSA synthesis in the presence of SIN-1. Hydroxyl Radical 119-135 MAPK associated protein 1 Homo sapiens 200-205 10366759-3 1999 Previously, we reported that exposing human dermal fibroblasts to UVA in the presence of AGEs that were prepared with bovine serum albumin (BSA) decreased the cell viability due to superoxide anion radical s (.O2(-)) and hydroxyl radicals (.OH) generated by AGEs under UVA irradiation, and active oxygen species are detected with ESR spin-trapping. Hydroxyl Radical 221-238 albumin Homo sapiens 125-138 10386999-6 1999 In the presence of Cu(II) or Fe(III), A beta produces a positive thiobarbituric-reactive substance (TBARS) assay, compatible with the generation of the hydroxyl radical (OH.). Hydroxyl Radical 152-168 amyloid beta precursor protein Homo sapiens 38-44 10362602-4 1999 Both superoxide (generated by xanthine oxidase plus hypoxanthine) and hydrogen peroxide were potent inducers of PAI-1, and hydroxyl radical scavengers completely abolished the TNF-alpha induction of PAI-1. Hydroxyl Radical 123-139 tumor necrosis factor Homo sapiens 176-185 10362602-4 1999 Both superoxide (generated by xanthine oxidase plus hypoxanthine) and hydrogen peroxide were potent inducers of PAI-1, and hydroxyl radical scavengers completely abolished the TNF-alpha induction of PAI-1. Hydroxyl Radical 123-139 serpin family E member 1 Homo sapiens 199-204 10350526-3 1999 We studied calpain expression in rat C6 glioma cells exposed to reactive hydroxyl radical (.OH) [formed via the Fenton reaction (Fe2++H2O2+H+-->Fe3++H2O+.OH)], interferon-gamma (IFN-gamma), and calcium ionophore (A23187). Hydroxyl Radical 73-89 interferon gamma Rattus norvegicus 163-179 10350526-3 1999 We studied calpain expression in rat C6 glioma cells exposed to reactive hydroxyl radical (.OH) [formed via the Fenton reaction (Fe2++H2O2+H+-->Fe3++H2O+.OH)], interferon-gamma (IFN-gamma), and calcium ionophore (A23187). Hydroxyl Radical 73-89 interferon gamma Rattus norvegicus 181-190 10336569-1 1999 The widely used sodium channel blocker tetrodotoxin (TTX) is a compound that has six hydroxyl residues at the C-4, C-6, C-8, C-9, C-10, and C-11 positions in addition to a guanidinium group, which is positively charged in biological pH range. Hydroxyl Radical 85-93 complement C6 Rattus norvegicus 115-118 10319417-1 1999 Cu,Zn-superoxide dismutase (SOD) can catalyze hydroxyl radical generation using H2O2 as a substrate. Hydroxyl Radical 46-62 superoxide dismutase 1 Homo sapiens 0-26 10095044-4 1999 On the other hand, superoxide dismutase (SOD), catalase and deferoxamine (DFX), which have inhibitory effects on the generation of O2-, H2O2 and hydroxyl radicals, respectively, protected the neurons. Hydroxyl Radical 145-162 catalase Homo sapiens 47-55 10391125-0 1999 The role of hydroxyl radical as a messenger in the activation of nuclear transcription factor NF-kappaB. Hydroxyl Radical 12-28 nuclear factor kappa B subunit 1 Homo sapiens 94-103 10223197-5 1999 Superoxide dismutase (SOD) and catalase inhibited AP-1 activation induced by vanadate, indicating the involvement of superoxide anion radical (O2-*), hydroxyl radical (*OH) and/or H2O2 in the mechanism of vanadate-induced AP-1 activation. Hydroxyl Radical 150-166 superoxide dismutase 1 Homo sapiens 0-20 10319417-1 1999 Cu,Zn-superoxide dismutase (SOD) can catalyze hydroxyl radical generation using H2O2 as a substrate. Hydroxyl Radical 46-62 superoxide dismutase 1 Homo sapiens 28-31 10319417-5 1999 Hydroxyl radical scavengers and copper chelator inhibited lipid peroxidation induced by the Cu,Zn-SOD and H2O2 system. Hydroxyl Radical 0-16 superoxide dismutase 1 Homo sapiens 98-101 10319417-6 1999 These results suggest that lipid peroxidation is mediated by the Cu,Zn-SOD and H2O2 system via the generation of hydroxyl radicals by a combination of the peroxidative reaction of Cu,Zn-SOD and the Fenton-like reaction of free copper released from oxidatively damaged SOD. Hydroxyl Radical 113-130 superoxide dismutase 1 Homo sapiens 71-74 10319417-6 1999 These results suggest that lipid peroxidation is mediated by the Cu,Zn-SOD and H2O2 system via the generation of hydroxyl radicals by a combination of the peroxidative reaction of Cu,Zn-SOD and the Fenton-like reaction of free copper released from oxidatively damaged SOD. Hydroxyl Radical 113-130 superoxide dismutase 1 Homo sapiens 186-189 10319417-6 1999 These results suggest that lipid peroxidation is mediated by the Cu,Zn-SOD and H2O2 system via the generation of hydroxyl radicals by a combination of the peroxidative reaction of Cu,Zn-SOD and the Fenton-like reaction of free copper released from oxidatively damaged SOD. Hydroxyl Radical 113-130 superoxide dismutase 1 Homo sapiens 186-189 10223197-5 1999 Superoxide dismutase (SOD) and catalase inhibited AP-1 activation induced by vanadate, indicating the involvement of superoxide anion radical (O2-*), hydroxyl radical (*OH) and/or H2O2 in the mechanism of vanadate-induced AP-1 activation. Hydroxyl Radical 150-166 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 50-54 10391125-2 1999 Our hypothesis is that hydroxyl radical (*OH) functions as a messenger for the activation of NF-kappaB. Hydroxyl Radical 23-39 nuclear factor kappa B subunit 1 Homo sapiens 93-102 10103001-4 1999 Here we show that horseradish peroxidase can also catalyze a third type of reaction that results in the production of hydroxyl radicals (.OH) from H2O2 in the presence of O2.-. Hydroxyl Radical 118-135 peroxidase Glycine max 30-40 10385054-3 1999 SOD-1 associated FALS mutants may have an altered radiation response due to an enhanced generation of hydroxyl radicals or a compromised ability to neutralize free radicals. Hydroxyl Radical 102-119 superoxide dismutase 1 Homo sapiens 0-5 10201833-3 1999 Results of time-course HPLC analysis indicate that the reactivity of the hydroxyl groups under this condition is in the following order; C-9 > C-4 > C-8 > C-7. Hydroxyl Radical 73-81 complement C9 Homo sapiens 137-140 10201833-3 1999 Results of time-course HPLC analysis indicate that the reactivity of the hydroxyl groups under this condition is in the following order; C-9 > C-4 > C-8 > C-7. Hydroxyl Radical 73-81 complement C4A (Rodgers blood group) Homo sapiens 146-149 10201833-3 1999 Results of time-course HPLC analysis indicate that the reactivity of the hydroxyl groups under this condition is in the following order; C-9 > C-4 > C-8 > C-7. Hydroxyl Radical 73-81 homeobox C8 Homo sapiens 155-158 10201833-3 1999 Results of time-course HPLC analysis indicate that the reactivity of the hydroxyl groups under this condition is in the following order; C-9 > C-4 > C-8 > C-7. Hydroxyl Radical 73-81 complement C7 Homo sapiens 164-167 9932891-8 1999 Both ebselen and catalase inhibited the contractile response to hydroxyl radical generated by ferrous ion (10(-3) mol/L) plus hydrogen peroxide (10(-2) mol/L). Hydroxyl Radical 64-80 catalase Oryctolagus cuniculus 17-25 9973556-1 1999 A newly developed 30 S subunit reconstitution system using a complete set of recombinant proteins was used to study the ribosomal RNA (rRNA) neighborhood of ribosomal protein S5 in 30 S subunits and 70 S ribosomes by directed hydroxyl radical probing. Hydroxyl Radical 226-242 ribosomal protein S5 Homo sapiens 157-177 9927288-7 1999 The inhibition of Epo formation by reactive O2 species could be completely antagonized by desferrioxamine and the hydroxyl radical-(OH*)-scavenger tetramethylthiourea. Hydroxyl Radical 114-130 erythropoietin Homo sapiens 18-21 9952297-0 1999 Increased hydroxyl radical production and apoptosis in PC12 neuron cells expressing the gain-of-function mutant G93A SOD1 gene. Hydroxyl Radical 10-26 superoxide dismutase 1 Rattus norvegicus 117-121 10052358-4 1999 We propose that by sequestering intracellular iron involved in generation of the very reactive hydroxyl radicals through a Fenton reaction, ferritin protects plant cells from oxidative damage induced by a wide range of stresses. Hydroxyl Radical 95-112 ferritin-1, chloroplastic Nicotiana tabacum 140-148 9952297-3 1999 Here we report that transfection of PC12 neuron precursor cells with the G93A mutation of SOD1 results in increased production of hydroxyl radicals (*OH) and an enhanced rate of cell death by apoptosis. Hydroxyl Radical 130-147 superoxide dismutase 1 Rattus norvegicus 90-94 9921712-5 1999 In an effort to identify the class of enzyme directly mediating TNFR Type II (75 kDa) shedding, a spectrum of carboxyl- (e.g., aspartate), hydroxyl- (e.g., serine), thiol (e.g., cysteine), and metalo- (e.g., Ca2+, Mg2+) protease-inhibiting agents were evaluated. Hydroxyl Radical 139-147 TNF receptor superfamily member 1A Homo sapiens 64-68 9878394-3 1999 Hydroxyl radical footprinting of in vitro reconstituted U1 snRNP demonstrated that riboses within a large continuous RNA region, including the Sm binding site, were protected. Hydroxyl Radical 0-16 glutamate receptor KA2 L homeolog Xenopus laevis 56-64 9921712-6 1999 Experimental findings implied that a carboxy (aspartate) peptidase, and possibly to a lesser extent, serine (hydroxyl), and thiol (cysteine) peptidases participate in macrophage TNFR Type II (75 kDa) shedding phenomena. Hydroxyl Radical 109-117 TNF receptor superfamily member 1A Homo sapiens 178-182 9877282-0 1998 Hydroxyl radical scavengers inhibit TNF-alpha production in mononuclear cells but not in polymorphonuclear leukocytes. Hydroxyl Radical 0-16 tumor necrosis factor Homo sapiens 36-45 9788510-11 1998 The extent of hydroxyl replacement by fluoride ranged from 17 to 72% and correlated with the surface area of the parent HAp. Hydroxyl Radical 14-22 reticulon 3 Homo sapiens 120-123 9872399-5 1998 In the present study, however, the increased erythropoietin synthesis could be related to a decreased intracellular hydroxyl radical level described as crucial for the oxygen regulated gene expression (Kietzmann et al., Biochem. Hydroxyl Radical 116-132 erythropoietin Homo sapiens 45-59 9879663-7 1998 The IC50 values of caeruloplasmin, hCP, and BSA for the superoxide radical were 12, 2, 260 microM and for the hydroxyl radical 15, 2, 200 microM. Hydroxyl Radical 110-126 coproporphyrinogen oxidase Homo sapiens 35-38 9851740-10 1998 Conversely, as the intensity of iron chelation increased, the release of IL-1-beta and TNF-alpha decreased, as was also shown with hydroxyl radical scavenging by dimethylthiourea. Hydroxyl Radical 131-147 interleukin 1 beta Homo sapiens 73-82 9851740-10 1998 Conversely, as the intensity of iron chelation increased, the release of IL-1-beta and TNF-alpha decreased, as was also shown with hydroxyl radical scavenging by dimethylthiourea. Hydroxyl Radical 131-147 tumor necrosis factor Homo sapiens 87-96 10189269-3 1998 The pH-rate expression was k(pH) = kH1 f1(aH+) + kH2 f2(aH+) + ks + kOH(aOH-), where kH1 and kH2 are the catalytic constants (M(-1) h(-1)) for hydrogen ion activity (aH+), kOH is the catalytic constant for hydroxyl ion activity (aOH-), and ks is the first-order rate constant (h(-1)) for spontaneous degradation. Hydroxyl Radical 206-214 potassium voltage-gated channel modifier subfamily G member 1 Homo sapiens 49-52 10189269-3 1998 The pH-rate expression was k(pH) = kH1 f1(aH+) + kH2 f2(aH+) + ks + kOH(aOH-), where kH1 and kH2 are the catalytic constants (M(-1) h(-1)) for hydrogen ion activity (aH+), kOH is the catalytic constant for hydroxyl ion activity (aOH-), and ks is the first-order rate constant (h(-1)) for spontaneous degradation. Hydroxyl Radical 206-214 potassium voltage-gated channel modifier subfamily F member 1 Homo sapiens 85-88 10189269-3 1998 The pH-rate expression was k(pH) = kH1 f1(aH+) + kH2 f2(aH+) + ks + kOH(aOH-), where kH1 and kH2 are the catalytic constants (M(-1) h(-1)) for hydrogen ion activity (aH+), kOH is the catalytic constant for hydroxyl ion activity (aOH-), and ks is the first-order rate constant (h(-1)) for spontaneous degradation. Hydroxyl Radical 206-214 potassium voltage-gated channel modifier subfamily G member 1 Homo sapiens 93-96 9820546-1 1998 Recent evidence indicates that free oxygen radicals, in particular hydroxyl radicals, may act as intracellular second messengers for the induction of IL-8, a potent chemoattractant and activator of neutrophil granulocytes. Hydroxyl Radical 67-84 C-X-C motif chemokine ligand 8 Homo sapiens 150-154 9848646-1 1998 The 16S ribosomal RNA neighborhood of ribosomal protein S20 has been mapped, in both 30S subunits and 70S ribosomes, using directed hydroxyl radical probing. Hydroxyl Radical 132-148 ribosomal protein S20 Homo sapiens 38-59 9804887-3 1998 Incubation of supercoiled pBR 322 DNA with HHQ at 0.1 mM in phosphate buffer (pH 7.4) at 37 degreesC for 1 h caused single strand breaks, and reactive oxygen species, hydrogen peroxide and hydroxyl radical, were involved in DNA breaking by HHQ. Hydroxyl Radical 189-205 translocator protein Homo sapiens 26-29 9759901-2 1998 The actions of a number of these oxidants (e.g., hydroxyl radical and peroxynitrite, a reactive oxidant produced by the reaction of nitric oxide and superoxide) are mediated in part by the activation of the nuclear nick sensor enzyme, poly(ADP)-ribose synthetase (PARS), with consequent cellular energy depletion. Hydroxyl Radical 49-65 poly(ADP-ribose) polymerase 1 Homo sapiens 235-262 9798929-1 1998 The Gly93-->Ala mutation in the Cu,Zn superoxide dismutase (Cu,Zn-SOD) gene (SOD1) found in some familial amyotrophic lateral sclerosis (FALS) patients has been shown to result in an aberrant increase in hydroxyl radical production by the mutant enzyme that may cause oxidative injury to spinal motor neurons. Hydroxyl Radical 204-220 superoxide dismutase 1 Homo sapiens 32-58 9798929-1 1998 The Gly93-->Ala mutation in the Cu,Zn superoxide dismutase (Cu,Zn-SOD) gene (SOD1) found in some familial amyotrophic lateral sclerosis (FALS) patients has been shown to result in an aberrant increase in hydroxyl radical production by the mutant enzyme that may cause oxidative injury to spinal motor neurons. Hydroxyl Radical 204-220 superoxide dismutase 1 Homo sapiens 60-69 9798929-1 1998 The Gly93-->Ala mutation in the Cu,Zn superoxide dismutase (Cu,Zn-SOD) gene (SOD1) found in some familial amyotrophic lateral sclerosis (FALS) patients has been shown to result in an aberrant increase in hydroxyl radical production by the mutant enzyme that may cause oxidative injury to spinal motor neurons. Hydroxyl Radical 204-220 superoxide dismutase 1 Homo sapiens 77-81 9798929-11 1998 These results suggest that the increased hydroxyl radical production associated with the G93A SOD1 mutation and/or lipid peroxidation-derived radical species (peroxyl or alkoxyl) causes extensive protein oxidative injury and that the Cu,Zn-SOD itself is a key target, which may compromise its antioxidant function. Hydroxyl Radical 41-57 superoxide dismutase 1, soluble Mus musculus 94-98 9798929-11 1998 These results suggest that the increased hydroxyl radical production associated with the G93A SOD1 mutation and/or lipid peroxidation-derived radical species (peroxyl or alkoxyl) causes extensive protein oxidative injury and that the Cu,Zn-SOD itself is a key target, which may compromise its antioxidant function. Hydroxyl Radical 41-57 superoxide dismutase 1, soluble Mus musculus 234-243 9859861-10 1998 Superoxide dismutase (SOD) was used to inhibit superoxide radicals and mannitol to inhibit hydroxyl radicals. Hydroxyl Radical 91-108 superoxide dismutase 1 Homo sapiens 0-20 9859861-10 1998 Superoxide dismutase (SOD) was used to inhibit superoxide radicals and mannitol to inhibit hydroxyl radicals. Hydroxyl Radical 91-108 superoxide dismutase 1 Homo sapiens 22-25 9759901-2 1998 The actions of a number of these oxidants (e.g., hydroxyl radical and peroxynitrite, a reactive oxidant produced by the reaction of nitric oxide and superoxide) are mediated in part by the activation of the nuclear nick sensor enzyme, poly(ADP)-ribose synthetase (PARS), with consequent cellular energy depletion. Hydroxyl Radical 49-65 poly(ADP-ribose) polymerase 1 Homo sapiens 264-268 9802549-6 1998 Cytokines, IL-1 and TNF enhanced the hydroxyl radical formation in phorbol 12-myristate 13-acetate treated chondrocytes. Hydroxyl Radical 37-45 interleukin 1 alpha Homo sapiens 11-23 9784165-1 1998 Petrocortyne D (2) is a 4,5-dihydro derivative of a diastereomer of petrocortyne A (1), and petrocortynes E-H (3-6) possess an additional allylic-hydroxyl group. Hydroxyl Radical 147-155 epoxide hydrolase 3 Homo sapiens 107-115 9826943-10 1998 SSB generation by hydroxyl radicals formed by 137Cs-gamma rays in Zn-treated cells decreased by 12%, accompanied by a decrease in d from 4.8 nm to 2.9 nm. Hydroxyl Radical 18-35 small RNA binding exonuclease protection factor La Homo sapiens 0-3 9736020-5 1998 Myoglobin heme iron could potentially serve as a Fenton reagent for the intracellular generation of hydroxyl radicals, which are responsible for the oxidation of the porphyrinogens. Hydroxyl Radical 100-117 myoglobin Homo sapiens 0-9 9787092-0 1998 Alkaline phosphatase and type I collagen gene expressions were reduced by hydroxyl radical-treated fibronectin substratum. Hydroxyl Radical 74-90 alkaline phosphatase, placental Homo sapiens 0-20 9725828-3 1998 Cells with null alleles in both STD1 and its homologue, MTH1, manifest numerous phenotypes observed in calcineurin mutants, including sodium, lithium, manganese, and hydroxyl ion sensitivity, as well as alpha factor toxicity. Hydroxyl Radical 166-174 Std1p Saccharomyces cerevisiae S288C 32-36 9725828-3 1998 Cells with null alleles in both STD1 and its homologue, MTH1, manifest numerous phenotypes observed in calcineurin mutants, including sodium, lithium, manganese, and hydroxyl ion sensitivity, as well as alpha factor toxicity. Hydroxyl Radical 166-174 Mth1p Saccharomyces cerevisiae S288C 56-60 9738658-6 1998 We report that a new family of elastase inhibitors ICI200355 and ZD0892 was found to be resistant toward superoxide, hypochlorous acid, hydrogen peroxide, hydroxyl radical, and peroxynitrite mediated degradation as well as having no effect on the formation of these oxidants by activated neutrophils. Hydroxyl Radical 155-171 elastase, neutrophil expressed Homo sapiens 31-39 9787092-0 1998 Alkaline phosphatase and type I collagen gene expressions were reduced by hydroxyl radical-treated fibronectin substratum. Hydroxyl Radical 74-90 fibronectin 1 Homo sapiens 99-110 9787092-1 1998 The influence of fibronectin (FN) substratum treated with hydroxyl radicals (.OH) generated by the H2O2-Cu2+ systems on osteoblast cells was studied. Hydroxyl Radical 58-75 fibronectin 1 Homo sapiens 17-28 9787092-1 1998 The influence of fibronectin (FN) substratum treated with hydroxyl radicals (.OH) generated by the H2O2-Cu2+ systems on osteoblast cells was studied. Hydroxyl Radical 58-75 fibronectin 1 Homo sapiens 30-32 9793838-6 1998 The inhibitory effects on AP-M were due to inactivation of the enzyme, irreversibly altered by flavonoids with a 2,3-double bond and a minimum of one hydroxyl substituent on each of the aromatic rings. Hydroxyl Radical 150-158 alanyl aminopeptidase, membrane Homo sapiens 26-30 9740130-5 1998 The scFv binding site on stem loop II was determined by footprinting experiments using RNase A, RNase V1, and hydroxyl radicals. Hydroxyl Radical 110-127 immunglobulin heavy chain variable region Homo sapiens 4-8 9749156-0 1998 [Effects of hydroxyl radicals on purified angiotensin I converting enzyme]. Hydroxyl Radical 12-29 angiotensinogen Homo sapiens 42-55 9749156-4 1998 In this study, we examined the impact of hydroxyl radicals (.OH) on purified ACE. Hydroxyl Radical 41-58 angiotensin I converting enzyme Homo sapiens 77-80 9668345-5 1998 MAG binding was abrogated by modification of the carboxylic acid, any hydroxyl, or the N-acetyl group of the ganglioside"s N-acetylneuraminic acid moiety. Hydroxyl Radical 70-78 myelin associated glycoprotein Homo sapiens 0-3 9693371-7 1998 Mutations that abolish the hydroxyl moiety at position 331 (A, D, and E) lead to missorting of endocytosed TGN38 to the lysosome. Hydroxyl Radical 27-35 trans-golgi network protein 2 Homo sapiens 107-112 9675034-10 1998 In conclusion, the estrogen receptor-mediated activation of MAO in conjunction with high catecholamine concentrations in the hamster kidney as previously reported may significantly increase the production of hydrogen peroxide and hydroxyl radicals which are postulated to contribute to tumor initiation. Hydroxyl Radical 230-247 monoamine oxidase A Rattus norvegicus 60-63 9668540-4 1998 The toxicity of NTPI is much higher than of transferrin-iron as judged by its ability to promote hydroxyl radical formation resulting in peroxidative damage to membrane lipids and proteins. Hydroxyl Radical 97-113 transferrin Homo sapiens 44-55 9702213-6 1998 Electron spin resonance (ESR) studies of these three cyclic tripeptide-DMQ-MA conjugates showed that hydroxyl radicals were generated as a non-linear function of L-ascorbic acid (AH2) concentration. Hydroxyl Radical 101-118 zinc finger RANBP2-type containing 3 Homo sapiens 179-182 9730236-0 1998 Binding affinity of Cu(II)-VP-16 (etoposide) complex and its analogues to DNA and hydroxyl radical generation during DNA strand breaks. Hydroxyl Radical 82-98 host cell factor C1 Homo sapiens 27-32 9618471-0 1998 Reexamination of the mechanism of hydroxyl radical adducts formed from the reaction between familial amyotrophic lateral sclerosis-associated Cu,Zn superoxide dismutase mutants and H2O2. Hydroxyl Radical 34-50 superoxide dismutase 1 Homo sapiens 148-168 9714320-5 1998 However, the rate constant of these catechol derivatives in scavenging hydroxyl radicals was < 10(10) M(-1) sec(-1), suggesting that they may not protect against biological damage induced by hydroxyl radicals. Hydroxyl Radical 71-88 secretory blood group 1, pseudogene Homo sapiens 111-117 9618471-2 1998 Mutations to Cu,Zn superoxide dismutase (SOD) linked with familial ALS are reported to increase hydroxyl radical adduct formation from hydrogen peroxide as measured by spin trapping with 5, 5"-dimethyl-1-pyrrolline N-oxide (DMPO). Hydroxyl Radical 96-112 superoxide dismutase 1 Homo sapiens 19-39 9618471-2 1998 Mutations to Cu,Zn superoxide dismutase (SOD) linked with familial ALS are reported to increase hydroxyl radical adduct formation from hydrogen peroxide as measured by spin trapping with 5, 5"-dimethyl-1-pyrrolline N-oxide (DMPO). Hydroxyl Radical 96-112 superoxide dismutase 1 Homo sapiens 41-44 9601082-6 1998 The results show that the resistance is specific to compounds that have apoptotic effects through the generation of hydroxyl radical or H2O2, including aggregated Abeta-(25-35), Abeta-(1-40), Abeta-(1-42), Abeta-(1-43), amylin, 6-hydroxydopamine and H2O2 itself. Hydroxyl Radical 116-132 islet amyloid polypeptide Rattus norvegicus 220-226 9614211-5 1998 These results indicate that hydroxyl radicals produced from superoxide anions and hydrogen peroxide in the presence of free iron, contribute to an increased MSR activity by stabilizing MSR-I mRNA. Hydroxyl Radical 28-45 progestin and adipoQ receptor family member 7 Homo sapiens 157-160 9614211-5 1998 These results indicate that hydroxyl radicals produced from superoxide anions and hydrogen peroxide in the presence of free iron, contribute to an increased MSR activity by stabilizing MSR-I mRNA. Hydroxyl Radical 28-45 progestin and adipoQ receptor family member 7 Homo sapiens 185-188 9578548-11 1998 The acyl-enzyme inhibitor hydroxyl is properly positioned for nucleophilic attack on the ester carbonyl and therefore relactonization; furthermore, the higher resolution structure of alpha-thrombin/GR133487 shows this hydroxyl to be effectively superimposable with the recently proposed deacylating water for peptide substrate hydrolysis [Wilmouth, R. C., et al. Hydroxyl Radical 26-34 coagulation factor II, thrombin Homo sapiens 189-197 9683009-1 1998 Peroxynitrite and hydroxyl radicals are potent initiators of DNA single strand breakage, which is an obligatory stimulus for the activation of the nuclear enzyme poly(ADP-ribose)synthetase (PARS). Hydroxyl Radical 18-35 poly(ADP-ribose) polymerase 1 Homo sapiens 162-188 9683009-1 1998 Peroxynitrite and hydroxyl radicals are potent initiators of DNA single strand breakage, which is an obligatory stimulus for the activation of the nuclear enzyme poly(ADP-ribose)synthetase (PARS). Hydroxyl Radical 18-35 poly(ADP-ribose) polymerase 1 Homo sapiens 190-194 9606965-5 1998 Experiments performed in the presence of superoxide dismutase, catalase, deferoxamine, and dimethyl sulfoxide excluded generation of hydroxyl radicals in significant amounts. Hydroxyl Radical 133-150 catalase Homo sapiens 63-71 9578548-11 1998 The acyl-enzyme inhibitor hydroxyl is properly positioned for nucleophilic attack on the ester carbonyl and therefore relactonization; furthermore, the higher resolution structure of alpha-thrombin/GR133487 shows this hydroxyl to be effectively superimposable with the recently proposed deacylating water for peptide substrate hydrolysis [Wilmouth, R. C., et al. Hydroxyl Radical 218-226 coagulation factor II, thrombin Homo sapiens 189-197 9545373-3 1998 Hydroxyl radical footprinting was exploited to investigate the binding of CRP and RNA polymerase holoenzyme (RNAP) to these promoters. Hydroxyl Radical 0-16 catabolite gene activator protein Escherichia coli 74-77 9538899-7 1998 In primary hippocampal cultures, EGF (0.048 to 6.0 ng/mL) extended the survival of cultured neurons, facilitated neurite outgrowth, and prevented neuronal damage caused by the hydroxyl radical-producing agent FeSO4 and by the peroxynitrite-producing agent 3-morpholinosydnonimine in a dose-dependent manner. Hydroxyl Radical 176-192 epidermal growth factor Homo sapiens 33-36 9548743-0 1998 Hydroxyl radical footprinting of DNA complexes of the ets domain of PU.1 and its comparison to the crystal structure. Hydroxyl Radical 0-16 spleen focus forming virus (SFFV) proviral integration oncogene Mus musculus 68-72 9548743-1 1998 Hydroxyl radical footprinting has been used to probe interactions in complexes between the ets domain of the murine transcription factor PU.1 and three different DNA restriction fragments, each containing one copy of the recognition sequence 5"-GGAA-3". Hydroxyl Radical 0-16 spleen focus forming virus (SFFV) proviral integration oncogene Mus musculus 137-141 9551094-6 1998 Using the hydroxyl radical as a chemical probe, we have examined complexes of Engrailed homeodomain with several DNA sequences to determine the protein"s binding specificity in solution. Hydroxyl Radical 10-26 engrailed Drosophila melanogaster 78-87 9492341-8 1998 The flavonoids that we tested have different hydroxyl and glucoside substituents on the A, B, and C rings, which allows us to define some of the spatial requirements for binding to AFP. Hydroxyl Radical 45-53 alpha-fetoprotein Rattus norvegicus 181-184 9478985-6 1998 The iron-driven generation of lipid peroxides and hydroxyl radicals were identified as early events in the downstream signaling pathway of the UVB response leading to a 15-fold increase in JNK2 activity, a 3.5-fold increase in c-jun, to a 6-fold increase in MMP-1, and a 3.8-fold increase in MMP-3 mRNA levels, while virtually no alteration of c-fos mRNA levels were observed. Hydroxyl Radical 50-67 mitogen-activated protein kinase 9 Homo sapiens 189-193 9478985-6 1998 The iron-driven generation of lipid peroxides and hydroxyl radicals were identified as early events in the downstream signaling pathway of the UVB response leading to a 15-fold increase in JNK2 activity, a 3.5-fold increase in c-jun, to a 6-fold increase in MMP-1, and a 3.8-fold increase in MMP-3 mRNA levels, while virtually no alteration of c-fos mRNA levels were observed. Hydroxyl Radical 50-67 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 227-232 9478985-6 1998 The iron-driven generation of lipid peroxides and hydroxyl radicals were identified as early events in the downstream signaling pathway of the UVB response leading to a 15-fold increase in JNK2 activity, a 3.5-fold increase in c-jun, to a 6-fold increase in MMP-1, and a 3.8-fold increase in MMP-3 mRNA levels, while virtually no alteration of c-fos mRNA levels were observed. Hydroxyl Radical 50-67 matrix metallopeptidase 1 Homo sapiens 258-263 9478985-6 1998 The iron-driven generation of lipid peroxides and hydroxyl radicals were identified as early events in the downstream signaling pathway of the UVB response leading to a 15-fold increase in JNK2 activity, a 3.5-fold increase in c-jun, to a 6-fold increase in MMP-1, and a 3.8-fold increase in MMP-3 mRNA levels, while virtually no alteration of c-fos mRNA levels were observed. Hydroxyl Radical 50-67 matrix metallopeptidase 3 Homo sapiens 292-297 9478985-6 1998 The iron-driven generation of lipid peroxides and hydroxyl radicals were identified as early events in the downstream signaling pathway of the UVB response leading to a 15-fold increase in JNK2 activity, a 3.5-fold increase in c-jun, to a 6-fold increase in MMP-1, and a 3.8-fold increase in MMP-3 mRNA levels, while virtually no alteration of c-fos mRNA levels were observed. Hydroxyl Radical 50-67 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 344-349 9512778-0 1998 Role of hydroxyl radical in silica-induced NF-kappa B activation in macrophages. Hydroxyl Radical 8-24 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 43-53 9638590-1 1998 We examined the effect of non-SH-containing angiotensin converting enzyme (ACE) inhibitor imidaprilat on hydroxyl radical (.OH) generation using microdialysis. Hydroxyl Radical 105-121 angiotensin I converting enzyme Rattus norvegicus 75-78 9489706-0 1998 Mapping the position of translational elongation factor EF-G in the ribosome by directed hydroxyl radical probing. Hydroxyl Radical 89-105 G elongation factor mitochondrial 1 Homo sapiens 56-60 9489706-1 1998 The interaction of translational elongation factor EF-G with the ribosome in the posttranslocational state has been mapped by directed hydroxyl radical probing. Hydroxyl Radical 135-151 G elongation factor mitochondrial 1 Homo sapiens 51-55 9489706-2 1998 Localized hydroxyl radicals were generated from Fe(II) tethered to 18 different sites on the surface of EF-G bound to the ribosome. Hydroxyl Radical 10-27 G elongation factor mitochondrial 1 Homo sapiens 104-108 9486220-2 1998 Cytosolic CA II catalyzes the buffering of intracellular hydroxyl ions by CO2, whereas membrane-bound CA IV catalyzes the dehydration of carbonic acid generated from the secretion of protons. Hydroxyl Radical 57-65 carbonic anhydrase 2 Oryctolagus cuniculus 10-15 32223123-1 1997 Absolute rate constants have been measured for the gas-phase reactions of hydroxyl radicals with a series of methyl esters: methyl propionate (k 1), methyl butyrate (k 2), methyl valerate (k 3), and methyl caproate (k 4). Hydroxyl Radical 74-91 keratin 1 Homo sapiens 143-146 9509420-0 1997 DNA cleavage by hydroxyl radicals generated in the Cu,Zn-superoxide dismutase and hydrogen peroxide system. Hydroxyl Radical 16-33 superoxide dismutase 1 Homo sapiens 51-77 9509420-1 1997 To study the catalytic activity of Cu,Zn-superoxide dismutase (SOD) in the generation of hydroxyl radical (.OH) from H2O2, we investigated the mechanism of DNA cleavage mediated by human Cu,Zn-SOD and H2O2. Hydroxyl Radical 89-105 superoxide dismutase 1 Homo sapiens 35-61 9509420-1 1997 To study the catalytic activity of Cu,Zn-superoxide dismutase (SOD) in the generation of hydroxyl radical (.OH) from H2O2, we investigated the mechanism of DNA cleavage mediated by human Cu,Zn-SOD and H2O2. Hydroxyl Radical 89-105 superoxide dismutase 1 Homo sapiens 63-66 32223123-1 1997 Absolute rate constants have been measured for the gas-phase reactions of hydroxyl radicals with a series of methyl esters: methyl propionate (k 1), methyl butyrate (k 2), methyl valerate (k 3), and methyl caproate (k 4). Hydroxyl Radical 74-91 RBPJ pseudogene 3 Homo sapiens 166-169 32223123-1 1997 Absolute rate constants have been measured for the gas-phase reactions of hydroxyl radicals with a series of methyl esters: methyl propionate (k 1), methyl butyrate (k 2), methyl valerate (k 3), and methyl caproate (k 4). Hydroxyl Radical 74-91 keratin 3 Homo sapiens 189-192 32223123-1 1997 Absolute rate constants have been measured for the gas-phase reactions of hydroxyl radicals with a series of methyl esters: methyl propionate (k 1), methyl butyrate (k 2), methyl valerate (k 3), and methyl caproate (k 4). Hydroxyl Radical 74-91 keratin 4 Homo sapiens 216-219 9409271-9 1997 Hydroxyl radicals, which may be generated inside cells from H2O2 via the Fenton reaction, also appeared to be involved in this effect, as hydroxyl radical scavengers downregulated TF activity and antigen levels (but not TF mRNA). Hydroxyl Radical 0-17 coagulation factor III, tissue factor Homo sapiens 180-182 9409271-9 1997 Hydroxyl radicals, which may be generated inside cells from H2O2 via the Fenton reaction, also appeared to be involved in this effect, as hydroxyl radical scavengers downregulated TF activity and antigen levels (but not TF mRNA). Hydroxyl Radical 138-154 coagulation factor III, tissue factor Homo sapiens 180-182 9371870-3 1997 Results of electrophoresis experiments suggested a comparable structure for 99mTc-HAG3 and 99mTc-MAG3, namely binding of an oxotechnetium(V)core via three deprotonated amides and a deprotonated hydroxyl group. Hydroxyl Radical 194-202 anterior gradient 3, protein disulphide isomerase family member Homo sapiens 82-86 9378980-3 1997 IL-6 induction was dependent on the intracellular redox-oxidative state, since intracellular hydroxyl scavengers and N-acetylcysteine, a precursor of glutathione, abrogated IL-6 secretion by asbestos or H2O2. Hydroxyl Radical 93-101 interleukin 6 Homo sapiens 0-4 21528298-1 1997 Xanthine oxidase (XO) and xanthine dehydrogenase (XDH) are alternate enzymatic forms of the XO/XDH protein that catalyzes the oxidation of hypoxanthine to xanthine, and xanthine to uric acid, and in the process XO/XDH generates reactive oxygen species (ROS) such as superoxide, hydrogen peroxide, and hydroxyl radicals. Hydroxyl Radical 301-318 xanthine dehydrogenase Homo sapiens 26-48 21528298-1 1997 Xanthine oxidase (XO) and xanthine dehydrogenase (XDH) are alternate enzymatic forms of the XO/XDH protein that catalyzes the oxidation of hypoxanthine to xanthine, and xanthine to uric acid, and in the process XO/XDH generates reactive oxygen species (ROS) such as superoxide, hydrogen peroxide, and hydroxyl radicals. Hydroxyl Radical 301-318 xanthine dehydrogenase Homo sapiens 50-53 21528298-1 1997 Xanthine oxidase (XO) and xanthine dehydrogenase (XDH) are alternate enzymatic forms of the XO/XDH protein that catalyzes the oxidation of hypoxanthine to xanthine, and xanthine to uric acid, and in the process XO/XDH generates reactive oxygen species (ROS) such as superoxide, hydrogen peroxide, and hydroxyl radicals. Hydroxyl Radical 301-318 xanthine dehydrogenase Homo sapiens 92-98 21528298-1 1997 Xanthine oxidase (XO) and xanthine dehydrogenase (XDH) are alternate enzymatic forms of the XO/XDH protein that catalyzes the oxidation of hypoxanthine to xanthine, and xanthine to uric acid, and in the process XO/XDH generates reactive oxygen species (ROS) such as superoxide, hydrogen peroxide, and hydroxyl radicals. Hydroxyl Radical 301-318 xanthine dehydrogenase Homo sapiens 95-98 9334236-2 1997 Here we have analyzed interactions of recombinant CBF with DNA using hydroxyl radical footprinting and methylation interference assays. Hydroxyl Radical 69-85 CCAAT enhancer binding protein zeta Homo sapiens 50-53 9550098-6 1997 Since these enzymes (EROD, CYP 1A1/2 and PROD, CYP2B1) activate polycyclic hydrocarbons, aromatic amines and aliphatic halogenated hydrocarbons to their ultimate mutagenic or carcinogenic forms, and are effective in producing reactive oxygen species such as superoxide, hydroxyl radical and hydrogen peroxide, the new compound, BITN, appears to have a greater anticarcinogenic and antioxidant potential than RA and BHT. Hydroxyl Radical 270-286 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 27-34 9550098-6 1997 Since these enzymes (EROD, CYP 1A1/2 and PROD, CYP2B1) activate polycyclic hydrocarbons, aromatic amines and aliphatic halogenated hydrocarbons to their ultimate mutagenic or carcinogenic forms, and are effective in producing reactive oxygen species such as superoxide, hydroxyl radical and hydrogen peroxide, the new compound, BITN, appears to have a greater anticarcinogenic and antioxidant potential than RA and BHT. Hydroxyl Radical 270-286 cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus 47-53 9378980-3 1997 IL-6 induction was dependent on the intracellular redox-oxidative state, since intracellular hydroxyl scavengers and N-acetylcysteine, a precursor of glutathione, abrogated IL-6 secretion by asbestos or H2O2. Hydroxyl Radical 93-101 interleukin 6 Homo sapiens 173-177 9378980-6 1997 Stimulation of DNA binding activity to the NF-kappa B and NF-IL-6 binding sites of the IL-6 promoter by asbestos or H2O2 were inhibited by tetramethylthiourea, a hydroxyl radical scavenger. Hydroxyl Radical 162-170 nuclear factor kappa B subunit 1 Homo sapiens 43-53 9378980-6 1997 Stimulation of DNA binding activity to the NF-kappa B and NF-IL-6 binding sites of the IL-6 promoter by asbestos or H2O2 were inhibited by tetramethylthiourea, a hydroxyl radical scavenger. Hydroxyl Radical 162-170 CCAAT enhancer binding protein beta Homo sapiens 58-65 9378980-6 1997 Stimulation of DNA binding activity to the NF-kappa B and NF-IL-6 binding sites of the IL-6 promoter by asbestos or H2O2 were inhibited by tetramethylthiourea, a hydroxyl radical scavenger. Hydroxyl Radical 162-170 interleukin 6 Homo sapiens 61-65 9337154-5 1997 In vivo studies, using wild-type Chinese hamster ovary (CHO) cells and CHO cells stably expressing liver MAT, demonstrate that the inactivation of MAT by H2O2 is specific to the hepatic enzyme, resulting from the modification of the cysteine residue 121, and that this effect is mediated by the generation of the hydroxyl radical. Hydroxyl Radical 313-329 methionine adenosyltransferase 1A Homo sapiens 105-108 9337154-5 1997 In vivo studies, using wild-type Chinese hamster ovary (CHO) cells and CHO cells stably expressing liver MAT, demonstrate that the inactivation of MAT by H2O2 is specific to the hepatic enzyme, resulting from the modification of the cysteine residue 121, and that this effect is mediated by the generation of the hydroxyl radical. Hydroxyl Radical 313-329 methionine adenosyltransferase 1A Homo sapiens 147-150 9337154-2 1997 Here we report that hydrogen peroxide (H2O2), via generation of hydroxyl radical, inactivates liver MAT by reversibly and covalently oxidizing an enzyme site. Hydroxyl Radical 64-80 methionine adenosyltransferase 1A Homo sapiens 100-103 9365024-7 1997 PUT-SOD administered in combination with PUT-CAT may eliminate both the superoxide radical and the H2O2 produced from the dismutation of superoxide, respectively, and thus prevent the formation of hydroxyl radicals. Hydroxyl Radical 197-214 catalase Rattus norvegicus 45-48 9363434-6 1997 FucT VI had an absolute requirement for a hydroxyl at C-6 of galactose in addition to the accepting hydroxyl at C-3. Hydroxyl Radical 42-50 fucosyltransferase 6 Homo sapiens 0-7 9350039-0 1997 Phosphorylation of inhibitory subunit of troponin and phospholamban in rat cardiomyocytes: modulation by exposure of cardiomyocytes to hydroxyl radicals and sulfhydryl group reagents. Hydroxyl Radical 135-152 troponin I3, cardiac type Rattus norvegicus 41-49 9337622-0 1997 Electron spin resonance evidence of the generation of superoxide anion, hydroxyl radical and singlet oxygen during the photohemolysis of human erythrocytes with bacteriochlorin a. Hydroxyl Radical 72-88 B cell linker Homo sapiens 161-178 9384253-4 1997 In addition, pretreatment with allopurinol (an inhibitor of xanthine oxidase) and 1,3-dimethylthiourea (a scavenger of hydroxyl radical) also produced a potent inhibition. Hydroxyl Radical 119-135 xanthine dehydrogenase Mus musculus 60-76 9312182-9 1997 These results suggest that Src family tyrosine kinases, Ras and Raf-1 are critical for ERK activation by hydroxyl radicals and that activation of ERKs may play an important role in protecting cardiac myocytes from apoptotic death following oxidative stress. Hydroxyl Radical 105-122 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 27-30 9312182-9 1997 These results suggest that Src family tyrosine kinases, Ras and Raf-1 are critical for ERK activation by hydroxyl radicals and that activation of ERKs may play an important role in protecting cardiac myocytes from apoptotic death following oxidative stress. Hydroxyl Radical 105-122 Raf-1 proto-oncogene, serine/threonine kinase Rattus norvegicus 64-69 9350039-3 1997 Brief exposure (1 min) of labelled myocytes to the hydroxyl radical generating system (H2O2 plus FeCl2) decreased markedly the stimulatory action of isoproterenol and forskolin on TN-I and PLN phosphorylation. Hydroxyl Radical 51-67 troponin I3, cardiac type Rattus norvegicus 180-184 9350039-3 1997 Brief exposure (1 min) of labelled myocytes to the hydroxyl radical generating system (H2O2 plus FeCl2) decreased markedly the stimulatory action of isoproterenol and forskolin on TN-I and PLN phosphorylation. Hydroxyl Radical 51-67 phospholamban Rattus norvegicus 189-192 9350039-8 1997 The results are consistent with the postulate that hydroxyl radical exposure of cardiomyocytes blunts the beta-adrenoceptor-mediated stimulation of adenylyl cyclase leading to decreased phosphorylation of TN-I and PLN and imply that such alterations account in part the reported depressed rate of relaxation of the myocardium exposed to oxygen free radicals. Hydroxyl Radical 51-67 troponin I3, cardiac type Rattus norvegicus 205-209 9350039-8 1997 The results are consistent with the postulate that hydroxyl radical exposure of cardiomyocytes blunts the beta-adrenoceptor-mediated stimulation of adenylyl cyclase leading to decreased phosphorylation of TN-I and PLN and imply that such alterations account in part the reported depressed rate of relaxation of the myocardium exposed to oxygen free radicals. Hydroxyl Radical 51-67 phospholamban Rattus norvegicus 214-217 9254714-7 1997 Hydroxyl radical footprinting identified the strongest site for binding of HMG-I(Y), and presumably for the other proteins as well, to be at the center of 4H. Hydroxyl Radical 0-16 high mobility group AT-hook 1 Homo sapiens 75-83 9231727-6 1997 The mutant CuZn-superoxide dismutase showed a minimal reduction in stability but did not differ significantly from the wild-type enzyme in enzymic activity, in content and affinity for active-site Cu ions and in the propensity to catalyze formation of hydroxyl radicals. Hydroxyl Radical 252-260 superoxide dismutase 1 Homo sapiens 11-36 9441906-5 1997 Addition of SOD mimic completely abolished the spectrum of the hydroxyl adduct but not the spectrum of the DMPO-glutathionyl radical adduct. Hydroxyl Radical 63-71 superoxide dismutase 1 Homo sapiens 12-15 9231752-0 1997 Differential vulnerability of the CA1 and CA3 subfields of the hippocampus to superoxide and hydroxyl radicals in vitro. Hydroxyl Radical 93-110 carbonic anhydrase 1 Homo sapiens 34-37 9231752-0 1997 Differential vulnerability of the CA1 and CA3 subfields of the hippocampus to superoxide and hydroxyl radicals in vitro. Hydroxyl Radical 93-110 carbonic anhydrase 3 Homo sapiens 42-45 9231752-4 1997 In contrast, hydroxyl radical-mediated damage, generated by exposure to 30 microM ferrous sulphate for 1 h, resulted in a CA3-dominant lesion. Hydroxyl Radical 13-29 carbonic anhydrase 3 Homo sapiens 122-125 9211842-2 1997 The reaction trajectory of IDH was modified (i) after the adenine moiety of nicotinamide adenine dinucleotide phosphate was changed to hypoxanthine (the 6-amino was changed to 6-hydroxyl), and (ii) by replacing Mg2+, which has six coordinating ligands, with Ca2+, which has eight coordinating ligands. Hydroxyl Radical 177-186 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 27-30 9201997-9 1997 Deoxy and/or methoxy derivatives of the 4-, 7-, 8-, or 9-position of sialic acid attenuated or eliminated binding of MAG, as did replacement of the sialic acid acetamido group with a hydroxyl. Hydroxyl Radical 183-191 myelin associated glycoprotein Homo sapiens 117-120 9047321-8 1997 The mechanism of augmentation by the phenolic hydroxyl does not appear to involve the acidic proton of estradiol, since CYP3A4-catalyzed estradiol 2-hydroxylation and testosterone 6-beta-hydroxylation were diminished to an equal extent when incubations were performed at increasing buffer pH values from 7 to 9. Hydroxyl Radical 46-54 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 120-126 9271786-7 1997 We conclude that hydroxyl radicals inhibit one or more steps in the cascade leading to phospholipase A2 activation and release of arachidonic acid from platelet phospholipid stores. Hydroxyl Radical 17-34 phospholipase A2 group IB Homo sapiens 87-103 9260868-7 1997 Increased cellular uptake and sequestration of iron in response to ICRF-187 may contribute to the protective activity of ICRF-187 by reducing the iron-anthracycline complex and iron-catalysed generation of hydroxyl radicals via the Haber-Weiss reaction. Hydroxyl Radical 206-214 regenerating family member 1 alpha Homo sapiens 67-71 9260868-7 1997 Increased cellular uptake and sequestration of iron in response to ICRF-187 may contribute to the protective activity of ICRF-187 by reducing the iron-anthracycline complex and iron-catalysed generation of hydroxyl radicals via the Haber-Weiss reaction. Hydroxyl Radical 206-214 regenerating family member 1 alpha Homo sapiens 121-125 9109655-15 1997 We propose a mechanism for the latter reaction in which Fe(III)-lipoxygenase abstracts the bisallylic hydrogen H-11 from 11-HP-12-ODEYA, yielding a hydroperoxyl radical which is subsequently cleaved into 11-oxo-ODEYA and a hydroxyl radical which may inactivate the enzyme. Hydroxyl Radical 223-239 linoleate 9S-lipoxygenase-4 Glycine max 64-76 9145928-7 1997 Both the hydroxyl and the ether oxygen atoms of the oxypropanol moiety seem to be required for binding at wild-type 5-HT1A receptors. Hydroxyl Radical 9-17 5-hydroxytryptamine receptor 1A Rattus norvegicus 116-122 9103434-11 1997 PAF inhibited H2O2-induced apoptosis in Ramos cells; it also attenuated H2O2- and alphaIgM-mediated increases in hydroxyl radical (OH.) Hydroxyl Radical 113-129 PCNA clamp associated factor Homo sapiens 0-3 9110146-5 1997 The ability of iron chelators to reduce Tat-potentiated TNF-induced NF-kappa B binding activity suggests that iron and intracellular hydroxyl radicals (OH.) Hydroxyl Radical 133-150 tyrosine aminotransferase Homo sapiens 40-43 9110146-5 1997 The ability of iron chelators to reduce Tat-potentiated TNF-induced NF-kappa B binding activity suggests that iron and intracellular hydroxyl radicals (OH.) Hydroxyl Radical 133-150 tumor necrosis factor Homo sapiens 56-59 9110146-5 1997 The ability of iron chelators to reduce Tat-potentiated TNF-induced NF-kappa B binding activity suggests that iron and intracellular hydroxyl radicals (OH.) Hydroxyl Radical 133-150 nuclear factor kappa B subunit 1 Homo sapiens 68-78 9119390-1 1997 Phenol- and monoamine-metabolizing sulfotransferases (STP and STM, respectively) are members of a superfamily of enzymes that add sulfate to a variety of xenobiotics and endobiotics containing hydroxyl or amino functional groups. Hydroxyl Radical 193-201 sulfotransferase family 1A member 1 Homo sapiens 54-57 9119390-1 1997 Phenol- and monoamine-metabolizing sulfotransferases (STP and STM, respectively) are members of a superfamily of enzymes that add sulfate to a variety of xenobiotics and endobiotics containing hydroxyl or amino functional groups. Hydroxyl Radical 193-201 sulfotransferase family 1A member 3 Homo sapiens 62-65 9047321-11 1997 To explain the mode via which the phenolic hydroxyl facilitates ortho hydroxylation, a mechanism in which the phenolic moiety attacks the iron-oxo double bond of CYP3A4, resulting in oxygen transfer to the ortho position, is proposed. Hydroxyl Radical 43-51 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 162-168 9083637-0 1997 Reduction of hydroxyl radical generation in a rat hindlimb model of ischemia-reperfusion injury using crosslinked hemoglobin-superoxide dismutase-catalase. Hydroxyl Radical 13-29 catalase Rattus norvegicus 146-154 9009148-7 1997 Cell death induced by c-myc expression was inhibited by the addition of catalase or dimethyl sulfoxide, a hydroxyl radical scavenger, or by increased intracellular expression of catalase. Hydroxyl Radical 106-122 MYC proto-oncogene, bHLH transcription factor Homo sapiens 22-27 9009148-7 1997 Cell death induced by c-myc expression was inhibited by the addition of catalase or dimethyl sulfoxide, a hydroxyl radical scavenger, or by increased intracellular expression of catalase. Hydroxyl Radical 106-122 catalase Homo sapiens 72-80 10074307-1 1997 In order to investigate the therapeutic effect of N-2-Mercaptopropionyl-glycine (MPG), a scavenger of hydroxyl radical, on postischemic myocardial dysfunction of 39 conscious unsedated dogs were undergone a 15 min occlusion of left anterior descending coronary artery followed by 48 hours of reperfusion. Hydroxyl Radical 102-118 N-methylpurine DNA glycosylase Canis lupus familiaris 50-79 8908200-10 1996 We conclude that LPS stimulates generation of intracellular ROS that regulate induction of the MnSOD gene at the transcriptional level further, we conclude that LPS-stimulated cytotoxicity involves both the xanthine oxidase pathway and perhaps intracellular generation of hydroxyl radicals. Hydroxyl Radical 272-289 superoxide dismutase [Mn], mitochondrial Bos taurus 95-100 8989833-8 1997 The hydroxyl radical scavenger dimethyl sulfoxide (DMSO) prevented the DETA NONOate induction of IL-8, suggesting the participation of the hydroxyl radical in the NO-induced IL-8 production. Hydroxyl Radical 4-20 C-X-C motif chemokine ligand 8 Homo sapiens 97-101 8989833-8 1997 The hydroxyl radical scavenger dimethyl sulfoxide (DMSO) prevented the DETA NONOate induction of IL-8, suggesting the participation of the hydroxyl radical in the NO-induced IL-8 production. Hydroxyl Radical 4-20 C-X-C motif chemokine ligand 8 Homo sapiens 174-178 8989833-8 1997 The hydroxyl radical scavenger dimethyl sulfoxide (DMSO) prevented the DETA NONOate induction of IL-8, suggesting the participation of the hydroxyl radical in the NO-induced IL-8 production. Hydroxyl Radical 139-155 C-X-C motif chemokine ligand 8 Homo sapiens 97-101 8989833-8 1997 The hydroxyl radical scavenger dimethyl sulfoxide (DMSO) prevented the DETA NONOate induction of IL-8, suggesting the participation of the hydroxyl radical in the NO-induced IL-8 production. Hydroxyl Radical 139-155 C-X-C motif chemokine ligand 8 Homo sapiens 174-178 8960560-9 1996 However, only compounds with a hydroxyl or an acetate group at C-4 displayed significantly reduced acute toxicity and sedative properties relative to those of 1. Hydroxyl Radical 31-39 complement C4A Rattus norvegicus 63-66 8969274-4 1996 Membrane permeable hydroxyl scavengers inhibited asbestos induced IL-8 expression. Hydroxyl Radical 19-27 C-X-C motif chemokine ligand 8 Homo sapiens 66-70 9013137-0 1997 Hydroxyl and peroxyl radical trapping by the monoamine oxidase-B inhibitors deprenyl and MDL 72,974A: implications for protection of biological substrates. Hydroxyl Radical 0-8 monoamine oxidase B Homo sapiens 45-64 8954577-10 1996 A hydroxyl radical-generating system (hydrogen peroxide irradiated with ultraviolet radiation) effectively inactivated PDH. Hydroxyl Radical 2-18 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 119-122 8954577-11 1996 These results demonstrate that PDH is susceptible to damage and inactivation by ROS and point to the involvement of Fenton chemistry and hydroxyl radicals formed through it in PDH inactivation by XO/HX. Hydroxyl Radical 137-154 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 31-34 8954577-11 1996 These results demonstrate that PDH is susceptible to damage and inactivation by ROS and point to the involvement of Fenton chemistry and hydroxyl radicals formed through it in PDH inactivation by XO/HX. Hydroxyl Radical 137-154 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 176-179 8752313-5 1996 The rates of formation of both hydrogen atoms and hydroxyl radicals were estimated to be equal to 25 microM min-1 in the sonolysis of pure water under argon. Hydroxyl Radical 50-67 CD59 molecule (CD59 blood group) Homo sapiens 108-113 8831752-0 1996 Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor. Hydroxyl Radical 75-83 cannabinoid receptor 2 Homo sapiens 111-114 8836047-14 1996 and H2O2 can directly but reversibly down-regulate the RNA-binding activity of IRP, causing transient decrease of free iron that otherwise would convert them into more potent oxidants such as hydroxyl radicals or equally aggressive iron-peroxo complexes. Hydroxyl Radical 192-209 Wnt family member 2 Homo sapiens 79-82 8667023-5 1996 Malonate-induced increases in levels of 2,3- and 2,5-dihydroxybenzoic acid/salicylate, markers of hydroxyl radical generation, were significantly attenuated in the nNOS knockout mice. Hydroxyl Radical 98-114 nitric oxide synthase 1, neuronal Mus musculus 164-168 8882955-0 1996 Role of hydroxyl radicals in radiation-induced activation of lyn tyrosine kinase in human B-cell precursors. Hydroxyl Radical 8-25 LYN proto-oncogene, Src family tyrosine kinase Homo sapiens 61-64 8658142-0 1996 Site-directed hydroxyl radical probing of the rRNA neighborhood of ribosomal protein S5. Hydroxyl Radical 14-30 ribosomal protein S5 Homo sapiens 67-87 8710492-1 1996 Hydroxyl radical footprinting has been used to study different open complexes between Escherichia coli RNA polymerase and the galactose operon regulatory region, which contains two overlapping promoters, P1 and P2. Hydroxyl Radical 0-16 replication initiation protein Escherichia coli 204-213 8728122-2 1996 We present the results of a study that used electron spin resonance (ESR) measurements to evaluate the level of hydroxyl radical production in bcl-2 expressing GT1-7 cells and control cells. Hydroxyl Radical 112-128 B cell leukemia/lymphoma 2 Mus musculus 143-148 8736536-8 1996 Results of hydroxyl radical footprinting and methylation interference assays indicate that XylS binds along one side of the DNA and covers four helical turns. Hydroxyl Radical 11-27 transcriptional activator of xyl-meta pathway operon Pseudomonas putida 91-95 8613691-5 1996 Treatment with hydroxyl radical scavengers such as dimethyl sulfoxide (DMSO) will decrease the production of IL-8 in stimulated human whole blood, fibroblasts, type II epithelial cells, and hepatoma cells, but not other cytokines. Hydroxyl Radical 15-31 C-X-C motif chemokine ligand 8 Homo sapiens 109-113 8613691-8 1996 The hydroxyl radical appears to be the final common pathway of cell activation for IL-8 synthesis, since DMSO will inhibit the NO-driven production of IL-8. Hydroxyl Radical 4-20 C-X-C motif chemokine ligand 8 Homo sapiens 83-87 8613691-8 1996 The hydroxyl radical appears to be the final common pathway of cell activation for IL-8 synthesis, since DMSO will inhibit the NO-driven production of IL-8. Hydroxyl Radical 4-20 C-X-C motif chemokine ligand 8 Homo sapiens 151-155 8691480-1 1996 Recent evidence suggests that intraneuronal metabolism of ethanol by catalase/H2O2 and an ethanol-inducible form of cytochrome P450 together generate acetaldehyde and oxygen radicals including the hydroxyl radical (HO.). Hydroxyl Radical 197-213 catalase Homo sapiens 69-77 8724989-5 1996 Systemic administration of NGF, BDNF and bFGF, but not NT-3 attenuated MPP+ induced increases in hydroxyl radical generation as assessed by the conversion of salicylate to 2,3- or 2,5-dihydroxybenzoic acid (DHBA). Hydroxyl Radical 97-113 nerve growth factor Rattus norvegicus 27-30 8724989-5 1996 Systemic administration of NGF, BDNF and bFGF, but not NT-3 attenuated MPP+ induced increases in hydroxyl radical generation as assessed by the conversion of salicylate to 2,3- or 2,5-dihydroxybenzoic acid (DHBA). Hydroxyl Radical 97-113 brain-derived neurotrophic factor Rattus norvegicus 32-36 8724989-5 1996 Systemic administration of NGF, BDNF and bFGF, but not NT-3 attenuated MPP+ induced increases in hydroxyl radical generation as assessed by the conversion of salicylate to 2,3- or 2,5-dihydroxybenzoic acid (DHBA). Hydroxyl Radical 97-113 fibroblast growth factor 2 Rattus norvegicus 41-45 8992503-13 1996 This suggests that both singlet oxygen and hydroxyl radical formation may be involved in near-UV damage to lens epithelial cell catalase. Hydroxyl Radical 43-59 catalase Oryctolagus cuniculus 128-136 8634251-8 1996 Hydroxyl radical footprinting revealed that Ixr1 protects an area of platinated DNA that is approximately 15 bp in size and centered at the platinum adduct. Hydroxyl Radical 0-16 DNA-binding transcription repressor IXR1 Saccharomyces cerevisiae S288C 44-48 8670069-5 1996 o-Phenanthroline and mannitol blocked GADD153 induction by H2O2, indicating that iron-generated hydroxyl radical mediates this induction. Hydroxyl Radical 96-112 DNA damage inducible transcript 3 Homo sapiens 38-45 8728122-2 1996 We present the results of a study that used electron spin resonance (ESR) measurements to evaluate the level of hydroxyl radical production in bcl-2 expressing GT1-7 cells and control cells. Hydroxyl Radical 112-128 solute carrier family 2 (facilitated glucose transporter), member 1 Mus musculus 160-163 8728122-5 1996 The mechanism by which the expression of bcl-2 leads to a decrease in cellular production of hydroxyl radical is unknown. Hydroxyl Radical 93-109 B cell leukemia/lymphoma 2 Mus musculus 41-46 8728124-2 1996 The reaction mixtures were analysed by reverse-phase HPLC, revealing the corresponding C-8 hydroxylated analogues as the major products of hydroxyl radical mediated attack. Hydroxyl Radical 139-155 homeobox C8 Homo sapiens 87-90 8886793-0 1996 Induction of c-jun protooncogene expression by hydrogen peroxide through hydroxyl radical generation and p60SRC tyrosine kinase activation. Hydroxyl Radical 73-89 jun proto-oncogene Mus musculus 13-18 8643080-8 1996 Similar to the HQ/Cu(II) and H202/Cu(II) systems, the DNA strand breaks mediated by HQ/Cu/Zn-SOD could not be effectively inhibited by the hydroxyl radical scavengers, including dimethylsulfoxide, mannitol, and 5,5-dimethyl-1-pyrroline N-oxide, but could be protected by sodium azide. Hydroxyl Radical 139-155 superoxide dismutase 1 Homo sapiens 93-96 8643080-10 1996 Alpha-(4-Pyridyl-1-oxide)-N-tert-butylnitrone (POBN)/spin-trapping studies demonstrated that the interaction of HQ with Cu/Zn-SOD, but not with Mn-SOD, resulted in the significant formation of POBN-CH3 adduct in the presence of dimethylsulfoxide, suggesting the production of hydroxyl radical or its equivalent from this enzyme/xenobiotic interaction. Hydroxyl Radical 276-292 superoxide dismutase 1 Homo sapiens 126-129 8631311-1 1996 In order to map the rRNA environment of the acceptor end of tRNA in th e ribosome, hydroxyl radicals were generated in situ from Fe(II) attached via an EDTA linker to the 5" end of tRNA. Hydroxyl Radical 83-100 mitochondrially encoded tRNA glycine Homo sapiens 60-64 8631311-1 1996 In order to map the rRNA environment of the acceptor end of tRNA in th e ribosome, hydroxyl radicals were generated in situ from Fe(II) attached via an EDTA linker to the 5" end of tRNA. Hydroxyl Radical 83-100 mitochondrially encoded tRNA glycine Homo sapiens 181-185 8955900-5 1996 A comparison of this messenger site with the S15 ribosomal binding site was conducted by analysing hydroxyl radical footprintings of these two sites. Hydroxyl Radical 99-115 ribosomal protein S15 Homo sapiens 45-48 8846270-4 1996 Superoxide, hydrogen peroxide and hydroxyl radical formation was measured by superoxide dismutase-inhibitable cytochrome c reduction, the dichlorofluorescin technique and the salicylate method, respectively. Hydroxyl Radical 34-50 LOC104968582 Bos taurus 110-122 8769737-7 1996 These results suggest that oxidative stress resulting from inhibition of endogenous Cu,Zn SOD causes induction of GAPDH gene expression and that the hydroxyl radical, produced through the iron-catalyzed Haber-Weiss reaction, is the intracellular reactive oxygen species responsible for the DDC-stimulated increase in GAPDH mRNA. Hydroxyl Radical 149-165 glyceraldehyde-3-phosphate dehydrogenase Oryctolagus cuniculus 317-322 8911636-2 1996 Samples containing nickel (III), of low crystallinity, with small particle size and high surface areas can in the presence of H2O2, cause the generation of the hydroxyl radical (as detected by spin trapping with 5,5-dimethyl-1-pyrroline N-oxide or DMPO) and/or another highly reactive species capable of cleaving the C-S bond in dimethyl sulphoxide. Hydroxyl Radical 160-176 spindlin 1 Homo sapiens 193-197 8903675-8 1996 It is proposed that ubiquinone-50 triggers the formation of hydroxyl radicals from 15-lipoxygenase-derived hydroperoxy-lipids via a Fenton-type reaction driven by ubisemiquinone radicals. Hydroxyl Radical 60-77 arachidonate 15-lipoxygenase Homo sapiens 83-98 8886793-2 1996 Pre-treatment of the cell with hydroxyl radical scavenger dimethyl sulfoxide (DMSO) abolishes the H2O2-induced c-jun expression. Hydroxyl Radical 31-47 jun proto-oncogene Mus musculus 111-116 9381409-5 1996 The repair of DNA strand breaks induced by gamma-radiation seems to be dependent on oxygen radical scavenging and the stimulation of PARP could be related to the protection of DNA strand breaks from hydroxyl radicals. Hydroxyl Radical 199-216 poly(ADP-ribose) polymerase 1 Homo sapiens 133-137 8831801-4 1996 The reaction constants of hydroxyl radicals with bromhexine and ambroxol were determined by competition kinetics to be 1.58 +/- 0.15 x 10(10) M-1S-1 and 1.04 +/- 0.1 x 10(10) M-1S-1, respectively. Hydroxyl Radical 26-43 tumor associated calcium signal transducer 2 Homo sapiens 142-154 8831801-4 1996 The reaction constants of hydroxyl radicals with bromhexine and ambroxol were determined by competition kinetics to be 1.58 +/- 0.15 x 10(10) M-1S-1 and 1.04 +/- 0.1 x 10(10) M-1S-1, respectively. Hydroxyl Radical 26-43 tumor associated calcium signal transducer 2 Homo sapiens 142-148 8831801-5 1996 N-acetyl-L-cysteine also reacted with hydroxyl radicals (1.28 +/- 0.14 x 10(10) M-1S-1) but not with superoxide radical. Hydroxyl Radical 38-55 tumor associated calcium signal transducer 2 Homo sapiens 80-86 7673115-13 1995 EPR spin trapping studies demonstrated the formation of hydroxyl radical from the decomposition of H2O2 by high concentrations of the Cu,Zn-SOD. Hydroxyl Radical 56-72 superoxide dismutase 1 Homo sapiens 140-143 8747843-4 1995 There was a positive correlation between the SOD activities in RBC and blood hydroxyl radical levels in the patients with ND, but neither the patients with SALS nor the controls showed such a correlation. Hydroxyl Radical 77-93 superoxide dismutase 1 Homo sapiens 45-48 8577068-6 1995 The mode of DNA cleavage, 3"-hydroxyl (OH)/5"-phosphoryl (P) ends, by homogeneously purified DNase gamma (Mr = 33 kDa) and its Zn2+ sensitivity match those observed in apoptosis in thymocytes induced by irradiation or glucocorticoid treatment, indicating that this endonuclease is a central component of the thymic apoptosis machinery. Hydroxyl Radical 29-37 deoxyribonuclease 1-like 3 Rattus norvegicus 93-104 7473714-3 1995 In this study, we used hydroxyl radical footprinting to show that OccR contacts only one face of the operator. Hydroxyl Radical 23-39 hypothetical protein Agrobacterium tumefaciens 66-70 7473714-9 1995 Operator DNA was bent toward the helical face that OccR protected from hydroxyl radicals, indicating that OccR occupies the interior angle of this bend. Hydroxyl Radical 71-88 hypothetical protein Agrobacterium tumefaciens 51-55 7473714-9 1995 Operator DNA was bent toward the helical face that OccR protected from hydroxyl radicals, indicating that OccR occupies the interior angle of this bend. Hydroxyl Radical 71-88 hypothetical protein Agrobacterium tumefaciens 106-110 7554117-6 1995 This enhancement was attenuated by iron chelation with deferoxamine and by the intracellular hydroxyl scavenger dimethylthiourea and mimicked by preincubation with purine/xanthine oxidase either alone or in the presence of superoxide dismutase. Hydroxyl Radical 93-101 xanthine dehydrogenase Mus musculus 171-187 7473756-10 1995 The results of this study compare favourably with the hydroxyl radical footprinting studies reported recently for a human cruciform binding protein (CBP), which binds at the base of the stem-loop structure and causes similar distortions of the stable cruciform structure. Hydroxyl Radical 54-70 CREB binding protein Homo sapiens 122-147 7473756-10 1995 The results of this study compare favourably with the hydroxyl radical footprinting studies reported recently for a human cruciform binding protein (CBP), which binds at the base of the stem-loop structure and causes similar distortions of the stable cruciform structure. Hydroxyl Radical 54-70 CREB binding protein Homo sapiens 149-152 7591271-3 1995 The aim of the present study was to explore whether inhibition of hydroxyl radicals, by complex binding Fe with desferrioxamine (DFO), counteracted the retardation in tumour growth rate after HAL and whether DFO in itself had an effect on tumour growth in 2 experimental rat liver tumours. Hydroxyl Radical 66-83 histidine ammonia lyase Rattus norvegicus 192-195 7578041-6 1995 The results described are fully consistent with the chemical mechanism for aldose reductase catalysis proposed previously (Bohren et al., 1994) and, furthermore, establish that binding of the spirohydantoin class of aldose reductase inhibitors, e.g., sorbinil, occurs via a reverse protonation scheme in which the ionized inhibitor binds preferentially to the *E.NADP+ complex with Tyr48 present as the protonated hydroxyl form. Hydroxyl Radical 414-422 aldo-keto reductase family 1 member B Homo sapiens 75-91 7578041-6 1995 The results described are fully consistent with the chemical mechanism for aldose reductase catalysis proposed previously (Bohren et al., 1994) and, furthermore, establish that binding of the spirohydantoin class of aldose reductase inhibitors, e.g., sorbinil, occurs via a reverse protonation scheme in which the ionized inhibitor binds preferentially to the *E.NADP+ complex with Tyr48 present as the protonated hydroxyl form. Hydroxyl Radical 414-422 aldo-keto reductase family 1 member B Homo sapiens 216-232 7586142-4 1995 Addition of Mn2+, which reacts with Cr(IV) and inhibits Cr(IV)-mediated hydroxyl radical (.OH) generation via Fenton-like reaction, attenuated the activation of NF-kappa B. Hydroxyl Radical 72-88 nuclear factor kappa B subunit 1 Homo sapiens 161-171 7539275-7 1995 Consistent with the role of iron on asbestos fibers in catalyzing hydroxyl radical generation, membrane-permeable hydroxyl radical scavengers (tetramethylthiourea, dimethyl sulfoxide) inhibited the asbestos-induced TNF-alpha response. Hydroxyl Radical 114-130 tumor necrosis factor Rattus norvegicus 215-224 7639532-1 1995 The observation of the hydroxyl radical spin adduct of 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) is evaluated as a probe for the production of hydroxyl radicals from the decomposition of peroxynitrite. Hydroxyl Radical 23-39 spindlin 1 Homo sapiens 40-44 7639532-1 1995 The observation of the hydroxyl radical spin adduct of 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) is evaluated as a probe for the production of hydroxyl radicals from the decomposition of peroxynitrite. Hydroxyl Radical 141-158 spindlin 1 Homo sapiens 40-44 7639532-2 1995 Although a weak signal corresponding to the DMPO-hydroxyl radical spin adduct (.DMPO-OH) is observed when peroxynitrite is allowed to decompose in the presence of DMPO, it is concluded that this does not constitute proof of the presence of free hydroxyl radicals. Hydroxyl Radical 245-262 spindlin 1 Homo sapiens 66-70 7474549-4 1995 Analysis by electron spin resonance spectrometry indicated that NPH4 scavenged superoxide anion radicals and hydroxyl radicals as well. Hydroxyl Radical 109-126 neurexophilin 4 Rattus norvegicus 64-68 7575988-4 1995 The AT preference of meta-Hoechst and Hoechst 33258 was probed further using hydroxyl radical footprinting on the tyrT DNA fragment, for which clear footprints were detected at AAT, AAA and ATAT runs, as for netropsin and distamycin. Hydroxyl Radical 77-93 serpin family A member 1 Homo sapiens 177-180 7639532-4 1995 This strongly suggests there is a reaction between DMPO and HOONO, or between DMPO and an activated intermediate of HOONO, to produce the hydroxyl radical spin adduct. Hydroxyl Radical 138-154 spindlin 1 Homo sapiens 155-159 7597052-2 1995 The role of the conserved hydroxyl was investigated by changing serine-131 to an alanine (S131A) in the dual-specific protein-tyrosine phosphatase VHR. Hydroxyl Radical 26-34 dual specificity phosphatase 3 Homo sapiens 147-150 7769095-0 1995 Protease-cleaved iron-transferrin augments oxidant-mediated endothelial cell injury via hydroxyl radical formation. Hydroxyl Radical 88-104 transferrin Homo sapiens 22-33 7786014-13 1995 However, when ONOO- was produced at a slower rate, either by SIN-1 or by H2O2/NaNO2 at acidic pH, hydroxyl radical scavengers were found to significantly enhance tyrosine nitration. Hydroxyl Radical 98-114 MAPK associated protein 1 Homo sapiens 61-66 7769095-1 1995 Previous work has shown that the Pseudomonas-derived protease, pseudomonas elastase (PAE), can modify transferrin to form iron complexes capable of catalyzing the formation of hydroxyl radical (.OH) from neutrophil (PMN)-derived superoxide (.O2-) and hydrogen peroxide (H2O2). Hydroxyl Radical 176-192 transferrin Homo sapiens 102-113 7568334-1 1995 The effects of clorgyline, the MAO-A inhibitor, and lazabemide, the MAO-B inhibitor, on the levels of the hydroxyl radicals appearing in the cerebral ventricles of mice during brain ischemia/reperfusion were examined by using a salicylate trapping method. Hydroxyl Radical 106-123 monoamine oxidase B Mus musculus 68-73 7673925-3 1995 Flavones and flavonols exhibited a strong inhibitory effect on trypsin; the presence of hydroxyl groups at positions C-5 and C-7 in ring A is necessary for inhibition of the enzyme, while the simultaneous presence of free hydroxyl groups at positions C-3" and C-4" enhances the inhibitory activity. Hydroxyl Radical 88-96 complement C5 Homo sapiens 117-120 7748188-0 1995 Effect of anti-inflammatory drugs on myeloperoxidase-dependent hydroxyl radical generation by human neutrophils. Hydroxyl Radical 63-79 myeloperoxidase Homo sapiens 37-52 7790027-4 1995 Deferoxamine (a ferric iron chelator) and dithiothreitol (a sulfhydryl reagent) both prevented DNA damage and cell killing, indicate that hydroxyl radicals generated from O2- and H2O2 produced by the mitochondria in a process catalysed by iron contributed to DNA damage and that this pathway may be involved in TNF-alpha-induced cytotoxicity. Hydroxyl Radical 138-155 tumor necrosis factor Mus musculus 311-320 7578933-4 1995 Separately, superoxide dismutase favors the formation of thiyl radicals while catalase favors the formation of hydroxyl radicals and AZQ semiquinone. Hydroxyl Radical 111-128 catalase Homo sapiens 78-86 7633562-0 1995 NADPH-cytochrome-P450 reductase promotes hydroxyl radical production by the iron complex of ADR-925, the hydrolysis product of ICRF-187 (dexrazoxane). Hydroxyl Radical 41-57 cytochrome p450 oxidoreductase Homo sapiens 0-31 7633562-3 1995 The ability of NADPH-cytochrome-P450 reductase to promote hydroxyl radical formation by iron complexes of ADR-925 and EDTA was compared by EPR spin trapping. Hydroxyl Radical 58-74 cytochrome p450 oxidoreductase Homo sapiens 15-46 7748188-7 1995 In this study, we explored this possibility by investigating the role of different classes of anti-inflammatory drugs to ameliorate hydroxyl radical generation via the myeloperoxidase-dependent pathway. Hydroxyl Radical 132-148 myeloperoxidase Homo sapiens 168-183 7748188-8 1995 In this paper, we report that meclofenamic acid inhibited myeloperoxidase-dependent hydroxyl radical generation through scavenging of hypochlorous acid and not by direct inhibition of myeloperoxidase. Hydroxyl Radical 84-100 myeloperoxidase Homo sapiens 58-73 7558184-1 1995 Inactivation of methionine synthase (MS) by nitrous oxide (N2O) administration to animals and man has been postulated to be mediated by hydroxyl radical (OH). Hydroxyl Radical 136-152 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 16-35 7706475-4 1995 The hydroxyl radical scavengers DMSO (1%), as well as di- and tetramethylthiourea, inhibited IL-1-, TNF alpha-, and LPS-induced COX-2 expression in rat mesangial cells. Hydroxyl Radical 4-20 tumor necrosis factor Rattus norvegicus 100-109 7706475-4 1995 The hydroxyl radical scavengers DMSO (1%), as well as di- and tetramethylthiourea, inhibited IL-1-, TNF alpha-, and LPS-induced COX-2 expression in rat mesangial cells. Hydroxyl Radical 4-20 cytochrome c oxidase II, mitochondrial Rattus norvegicus 128-133 7890714-7 1995 Furthermore, substrate binding by wild-type PI-SceI stimulates hydroxyl radical or hydroxide ion attack at the cleavage site while binding by the alanine-substituted proteins either stimulates this attack significantly less or protects the DNA at this position. Hydroxyl Radical 63-79 intron-encoded endonuclease I-SceI Saccharomyces cerevisiae S288C 47-51 7826364-2 1995 When fibroblasts were exposed to UV light (UVA + UVB), hydroxyl radicals were detectable by ESR-spin trapping using DMPO as a spin trapping agent. Hydroxyl Radical 55-72 esterase 5 regulator Mus musculus 92-95 7695161-13 1995 Both events were only partially blocked by catalase (approximately 40%), but almost completely abolished by deferoxamine, a chelator of ferrous ions, suggesting that hydroxyl radicals produced in endothelial cells themselves from xanthine oxidase may injure the cells from their inside. Hydroxyl Radical 166-183 catalase Homo sapiens 43-51 7757199-7 1995 These results provide evidence that hydroxyl radical and other active oxygen species have a potential to react with EPO, leading to a reduction of its in vivo activity. Hydroxyl Radical 36-52 erythropoietin Homo sapiens 116-119 7617519-4 1995 It is shown in this study that these oxidations can be retarded by catalase in a pH-dependent manner, by some hydroxyl radical scavengers, and by azide. Hydroxyl Radical 110-126 catalase Homo sapiens 67-75 7826371-4 1995 On the other hand, the induction of hsp70 gene mRNA was not significant during the early period of treatment by 0.5 mM hydrogen peroxide and was occurred after 5 h. DNA damage induced by Adriamycin further supported the possible correlation between hydroxyl radical-mediated cleavage of DNA and nuclear translocation of hsp70 protein. Hydroxyl Radical 249-265 heat shock protein family A (Hsp70) member 4 Homo sapiens 36-41 7826371-4 1995 On the other hand, the induction of hsp70 gene mRNA was not significant during the early period of treatment by 0.5 mM hydrogen peroxide and was occurred after 5 h. DNA damage induced by Adriamycin further supported the possible correlation between hydroxyl radical-mediated cleavage of DNA and nuclear translocation of hsp70 protein. Hydroxyl Radical 249-265 heat shock protein family A (Hsp70) member 4 Homo sapiens 320-325 7961724-0 1994 Eosinophil peroxidase-dependent hydroxyl radical generation by human eosinophils. Hydroxyl Radical 32-48 eosinophil peroxidase Homo sapiens 0-21 7720785-6 1995 Moreover, in vitro addition of manganese-superoxide dismutase, a superoxide anion scavenger, or dimethyl sulfoxide (DMSO), a hydroxyl radical scavenger, also showed potent inhibition. Hydroxyl Radical 125-141 superoxide dismutase 2 Rattus norvegicus 31-61 7788439-6 1995 Hydroxyl radicals stimulate the transformation of the transmembrane form of TNF alpha into its soluble form which is secreted into the medium. Hydroxyl Radical 0-17 tumor necrosis factor Homo sapiens 76-85 7744228-1 1995 Since copper [Cu(II)] is a necessary cofactor for both intra-mitochondrial enzymes involved in energy production and hydroxyl scavenger enzymes, two hypothesised mechanisms for action of interleukin-I beta (IL-1 beta), we studied whether Cu(II) addition could prevent the inhibitory effect of IL-1 beta on insulin release and glucose oxidation in rat pancreatic islets. Hydroxyl Radical 117-125 interleukin 1 beta Rattus norvegicus 207-216 8696300-4 1995 The results suggest that IFN-alpha suppresses the NMDA responses through its action on opioid receptors and the production of free radicals such as hydroxyl radicals and nitric oxide (NO) due to the neuron-glial cell interactions. Hydroxyl Radical 148-165 interferon alpha 1 Homo sapiens 25-34 7981061-6 1994 The cell killing effect caused by titanium dioxide particles plus UV light irradiation was significantly hampered in the presence of L-cysteine and catalase, scavengers of hydroxyl radicals and hydrogen peroxide respectively. Hydroxyl Radical 172-189 catalase Homo sapiens 133-156 7705290-3 1994 The studies reported herein demonstrate that hydroxyl radical-induced DNA damage can activate the K-ras 4B and C-Raf-l oncogenes by causing point mutations and deletions, respectively. Hydroxyl Radical 45-61 KRAS proto-oncogene, GTPase Homo sapiens 98-106 7705290-3 1994 The studies reported herein demonstrate that hydroxyl radical-induced DNA damage can activate the K-ras 4B and C-Raf-l oncogenes by causing point mutations and deletions, respectively. Hydroxyl Radical 45-61 Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens 111-116 7819227-0 1995 Role of quinone-mediated generation of hydroxyl radicals in the induction of glutathione S-transferase gene expression. Hydroxyl Radical 39-56 glutathione S-transferase kappa 1 Homo sapiens 77-102 7758538-1 1995 The enzyme catalase protects aerobic organisms from oxygen free radical damage by converting hydrogen peroxide to molecular oxygen and water before it can decompose to form the highly reactive hydroxyl radical. Hydroxyl Radical 193-209 Catalase Drosophila melanogaster 11-19 7814447-9 1995 These results indicate that the effect of X-XO on calcium homeostasis appears to result from an interaction of O2- and H2O2, which could be explained by the formation of the hydroxyl radical. Hydroxyl Radical 174-190 immunoglobulin kappa variable 1D-39 Homo sapiens 111-123 7770640-5 1995 Dimethylsulfoxide (DMSO), catalase (CAT), and deferoxamine (DFO) significantly inhibited hydroxyl radicals enhanced by gentamicin, but superoxide dismutase (SOD) and metallothionein-1 (MT1) did not. Hydroxyl Radical 89-106 catalase Rattus norvegicus 26-34 7770640-5 1995 Dimethylsulfoxide (DMSO), catalase (CAT), and deferoxamine (DFO) significantly inhibited hydroxyl radicals enhanced by gentamicin, but superoxide dismutase (SOD) and metallothionein-1 (MT1) did not. Hydroxyl Radical 89-106 catalase Rattus norvegicus 36-39 7770640-5 1995 Dimethylsulfoxide (DMSO), catalase (CAT), and deferoxamine (DFO) significantly inhibited hydroxyl radicals enhanced by gentamicin, but superoxide dismutase (SOD) and metallothionein-1 (MT1) did not. Hydroxyl Radical 89-106 metallothionein 1 Rattus norvegicus 185-188 7496602-4 1995 Therefore, peroxisomal catalase also acts as an antioxidant defence mechanism by removing H2O2 and preventing the formation of hydroxyl radicals in the cell. Hydroxyl Radical 127-144 catalase Rattus norvegicus 23-31 7811256-5 1994 The spin adducts of superoxide and hydroxyl radical (DMPO-OOH and DMPO-OH, respectively) were generated in the reaction of NCS with the NADPH/cyt P-450 reductase system. Hydroxyl Radical 35-51 2,4-dienoyl-CoA reductase 1 Homo sapiens 136-141 7996046-5 1994 NAC reduced ferricytochrome c and increased dose-dependently Fe(III)-citrate and Fe(III)-EDTA-catalyzed hydroxyl radical formation in a system using glucose and glucose oxidase. Hydroxyl Radical 104-120 X-linked Kx blood group Homo sapiens 0-3 7850993-4 1994 This may react with the Cu atom of SOD in a Fenton-type reaction producing the hydroxyl radical (.OH). Hydroxyl Radical 79-95 superoxide dismutase 1 Homo sapiens 35-38 7893388-1 1994 It has been demonstrated by cytochrome C colorimetry that the Taohong Siwu Decoction (TF) is effective in hydroxyl radical scavenging. Hydroxyl Radical 106-122 cytochrome c, somatic Homo sapiens 28-40 7997158-8 1994 Pretreatment of the target tissues with Proteinase K decreased the gonococcal binding dramatically, whereas pretreatment with neuraminidase and meta-periodate, which cleave carbon-carbon linkages between vicinal hydroxyl groups in carbohydrates, did not affect attachment of gonococci. Hydroxyl Radical 212-220 neuraminidase 1 Homo sapiens 126-139 7945202-6 1994 DNA strand cleavage was prevented by catalase, superoxide dismutase, GSH and hydroxyl-radical-scavenging agents, suggesting that a hydroxyl-radical-like species was the oxidant responsible for the breakage. Hydroxyl Radical 131-147 catalase Rattus norvegicus 37-45 7528849-7 1994 Treatment with hr-EC-SOD C, but not with bovine SOD, resulted in reduction in hydroxyl radical formation assessed by 5-5-dimethy-1-pyrroline-N-oxide spin trap (DMPO) in coronary effluent at early reperfusion with electron spin resonance (ESR) technique. Hydroxyl Radical 78-94 superoxide dismutase 3 Rattus norvegicus 21-24 7812613-18 1994 The EFS-induced generation of hydroxyl radicals was dependent on the period of stimulation and 02-bubbling, and significant generation of hydroxyl radicals was detectable with stimulation of over 5 min.Moreover, hydroxyl radicals generated in 50 mM NaCl solution containing 10 nM ET-1 by H202 plus Fe2 , i.e. the Fenton reaction, significantly decreased the level of ir-ET-l.8. Hydroxyl Radical 138-155 endothelin 1 Homo sapiens 280-284 7812613-18 1994 The EFS-induced generation of hydroxyl radicals was dependent on the period of stimulation and 02-bubbling, and significant generation of hydroxyl radicals was detectable with stimulation of over 5 min.Moreover, hydroxyl radicals generated in 50 mM NaCl solution containing 10 nM ET-1 by H202 plus Fe2 , i.e. the Fenton reaction, significantly decreased the level of ir-ET-l.8. Hydroxyl Radical 138-155 endothelin 1 Homo sapiens 280-284 8041736-0 1994 Cytochrome P-450 mediates tissue-damaging hydroxyl radical formation during reoxygenation of the kidney. Hydroxyl Radical 42-58 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 0-16 8041736-11 1994 In summary, several chemically distinct cytochrome P-450 inhibitors reduced iron release, and thereby, hydroxyl radical formation and reoxygenation-induced lethal cell injury, without inhibiting superoxide radical formation. Hydroxyl Radical 103-119 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 40-56 8033884-6 1994 Hydrogen-bonding interactions are almost exclusively restricted to the other side of the molecule: the C-4" and C-6" hydroxyl groups act as donors of the strongest hydrogen bonds to charged groups of the lectin, while the C-3 hydroxyl group participates in a strong hydrogen bond with a neutral group. Hydroxyl Radical 117-125 complement C4 Bos taurus 103-106 8033884-6 1994 Hydrogen-bonding interactions are almost exclusively restricted to the other side of the molecule: the C-4" and C-6" hydroxyl groups act as donors of the strongest hydrogen bonds to charged groups of the lectin, while the C-3 hydroxyl group participates in a strong hydrogen bond with a neutral group. Hydroxyl Radical 117-125 complement C6 Bos taurus 112-115 8033884-6 1994 Hydrogen-bonding interactions are almost exclusively restricted to the other side of the molecule: the C-4" and C-6" hydroxyl groups act as donors of the strongest hydrogen bonds to charged groups of the lectin, while the C-3 hydroxyl group participates in a strong hydrogen bond with a neutral group. Hydroxyl Radical 117-125 complement C3 Bos taurus 222-225 7925615-4 1994 It has been shown that histamine H2 receptor antagonists such as cimetidine, ranitidine and famotidine are good hydroxyl radical scavengers. Hydroxyl Radical 112-128 histamine receptor H2 Homo sapiens 23-44 8021169-5 1994 In this work, we determined the sequences of eight VirF-binding sites from four different genes, by DNase I or hydroxyl radical footprinting. Hydroxyl Radical 111-127 virF Yersinia enterocolitica 51-55 7532433-1 1994 OBJECTIVES: This study was performed to observe the effects of conditioned media (CM) of cultured mononuclear cells (MNC) on the expression of beta 1 integrin and intercellular adhesion molecule(ICAM)-1 on mesangial cells and the modulation by TGF-beta, TNF alpha, or hydroxyl radical Also these were examined in anti-Thy mesangial proliferative GN (MsPGN) or puromycin aminonucleoside nephrosis(PAN). Hydroxyl Radical 268-284 intercellular adhesion molecule 1 Homo sapiens 143-202 7532433-11 1994 In MsPGN, the overexpression of beta 1 integrin induced by MNC through TGF beta or hydroxyl radical on day 3 may be related to the pathogenesis. Hydroxyl Radical 83-99 integrin subunit beta 1 Homo sapiens 32-47 8136906-12 1994 Hydroxyl radical scavengers, superoxide dismutase plus catalase, completely inhibited the formation of these lipid metabolites, demonstrating that the release of lipid metabolites from the isolated heart was indeed in response to oxidative stress. Hydroxyl Radical 0-16 catalase Rattus norvegicus 55-63 8075364-9 1994 The bases determined were typical products of hydroxyl radical attack on DNA, suggesting a role for this radical in the mechanism(s) of DNA damage caused by Co(II) in vivo. Hydroxyl Radical 46-62 cytochrome c oxidase II, mitochondrial Rattus norvegicus 157-163 8161207-0 1994 Spin trapping of azidyl and hydroxyl radicals in azide-inhibited rat brain submitochondrial particles. Hydroxyl Radical 28-45 spindlin 1 Rattus norvegicus 0-4 8139004-2 1994 Coat protein and peptide binding sites in the 3" UTR of alfalfa mosaic virus RNA 4 have been analyzed by hydroxyl radical footprinting, deletion mapping, and site-directed mutagenesis experiments. Hydroxyl Radical 105-121 coat protein Alfalfa mosaic virus 0-12 8139004-4 1994 Hydroxyl radical footprinting data show that five sites in the 3" UTR of alfalfa mosaic virus RNA 4 are protected by coat protein, and four of the five protected regions contain AUGC or UUGC. Hydroxyl Radical 0-16 coat protein Alfalfa mosaic virus 117-129 8107104-1 1994 The position of chromosomal proteins HMG-14 and HMG-17 in nucleosome cores and in chromatosomes lacking linker histones has been mapped by hydroxyl radical footprinting. Hydroxyl Radical 139-155 high mobility group nucleosome binding domain 1 Homo sapiens 37-43 8107104-1 1994 The position of chromosomal proteins HMG-14 and HMG-17 in nucleosome cores and in chromatosomes lacking linker histones has been mapped by hydroxyl radical footprinting. Hydroxyl Radical 139-155 high mobility group nucleosomal binding domain 2 Homo sapiens 48-54 8200975-11 1994 Thus, superoxide-mediated, iron-catalyzed formation of hydroxyl radicals can rapidly and irreversibly inactivate PAF acetylhydrolase. Hydroxyl Radical 55-72 phospholipase A2 group VII Homo sapiens 113-132 7524120-3 1994 This bradykinin-induced oxidation of DCFH was inhibited by pretreatment with N-(2-mercaptopropionyl)-glycine (MPG) and 1,3-dimethyl-thiourea (DMTU), scavengers of hydroxyl radical, and the removal of extracellular Ca2+ but was unaffected by NG-nitro-L-arginine or NG-monomethyl-L-arginine, both inhibitors of nitric oxide (NO) synthase. Hydroxyl Radical 163-179 kininogen 1 Bos taurus 5-15 7524120-5 1994 These findings suggest that bradykinin increases intracellular Ca2+ and stimulates the generation of hydroxyl radical-like reactive oxygen species (scavenged by MPG or DMTU) via the cyclooxygenase pathway but not via the reaction of NO and superoxide anion. Hydroxyl Radical 101-117 kininogen 1 Bos taurus 28-38 8155661-4 1994 The adduct with the unsubstituted hydrazine was instead assigned an o-quinone hydrazone form, stabilized by an internal hydrogen bond between the amino group and the ortho carbonyl oxygen, a larger electron delocalization, and formation of a hydrogen bond at the C-6 ionized hydroxyl. Hydroxyl Radical 275-283 complement C6 Homo sapiens 263-266 8123012-3 1994 The human RBC PRP (HRPRP) completely inhibited visible absorption spectral changes of oxyhemoglobin, DNA cleavage, and the peroxidation of RBC membrane by a nonenzymatic Fe3+/O2/thiol mixed-function oxidation system capable of generating hydroxyl radical. Hydroxyl Radical 238-254 prion protein Homo sapiens 14-17 8304825-3 1994 RESULTS: Scavenging of the hydroxyl radical with the membrane-permeable scavenger dimethyl sulfoxide or blocking its generation via the Fenton reaction by the chelation of iron with o-phenanthroline blocked apoptosis, whereas the cell membrane-impermeable scavengers superoxide dismutase and catalase did not block apoptosis. Hydroxyl Radical 27-43 catalase Homo sapiens 292-300 8311476-6 1994 The ferritin-catalyzed hydroxyl radical scavenger oxidation was sensitive to superoxide dismutase, catalase, and competitive scavengers. Hydroxyl Radical 23-39 catalase Rattus norvegicus 99-107 8012523-3 1994 Compared to the spin trap 5,5-dimethyl-pyrroline-1-oxide, a higher lifetime of hydroxyl radical adducts and a higher selectivity related to the trapping of carbon-centered radicals was found. Hydroxyl Radical 79-95 spindlin 1 Homo sapiens 16-20 8012524-2 1994 When human granulocytes are stimulated with TPA, they release a large quantity of reactive oxygen species (superoxide, hydrogen peroxide) which might be expected to generate hydroxyl radicals (OH.) Hydroxyl Radical 174-191 plasminogen activator, tissue type Homo sapiens 44-47 8106325-8 1994 Footprinting experiments using hydroxyl radicals and dimethyl sulfate demonstrated that DtxR interacted with these operators in a symmetrical manner, probably as a dimer or multimer. Hydroxyl Radical 31-48 MarR family transcriptional regulator Corynebacterium diphtheriae 88-92 8114010-12 1994 A significant amount of hydroxyl radical was detected in the ischemic reperfused heart, but the quantity of the hydroxyl radical was much lower in the VIP-treated group. Hydroxyl Radical 24-40 vasoactive intestinal peptide Rattus norvegicus 151-154 8114010-12 1994 A significant amount of hydroxyl radical was detected in the ischemic reperfused heart, but the quantity of the hydroxyl radical was much lower in the VIP-treated group. Hydroxyl Radical 112-128 vasoactive intestinal peptide Rattus norvegicus 151-154 7934152-5 1994 DMTU, SOD, and catalase were employed for the scavenging of hydroxyl radical, superoxide anion, and hydrogen peroxide, respectively. Hydroxyl Radical 60-76 superoxide dismutase [Mn], mitochondrial Cavia porcellus 6-9 7910930-5 1994 Expression of ICAM-1 on AK-D appeared when AK-D was stimulated by hydroxyl radical but did not when AK-D was cultured with meconium. Hydroxyl Radical 66-82 intercellular adhesion molecule 1 Homo sapiens 14-20 8218378-0 1993 Oxidative damage to lysozyme by the hydroxyl radical: comparative effects of scavengers. Hydroxyl Radical 36-52 lysozyme Homo sapiens 20-28 8225581-3 1993 This cleavage also generates new iron chelates which, in contrast to iron bound to transferrin, are able to catalyze formation of the highly cytotoxic hydroxyl radical from neutrophil-derived superoxide and hydrogen peroxide via the Haber-Weiss reaction. Hydroxyl Radical 151-167 transferrin Homo sapiens 83-94 8015448-0 1994 Spin trapping of hydroxyl radicals in biological systems. Hydroxyl Radical 17-34 spindlin 1 Homo sapiens 0-4 7953289-3 1994 Activation of Tyr377 in the beta 1-adrenoceptor is achieved by a direct hydrogen bond interaction of the para-hydroxy moiety and by an indirect action of the beta-hydroxyl group involving reversal of a hydrogen bond relay. Hydroxyl Radical 163-171 adrenoceptor beta 1 Homo sapiens 28-47 8262987-4 1993 The side chain hydroxyl group causes: stabilization of zinc-hydroxide relative to zinc-water (pKa increases approximately 2 units); stabilization of the transition state for bicarbonate dehydration relative to the CAII.HCO3- complex (approximately 5 kcal/mol); and destabilization of the CAII.HCO3- complex (approximately 0.8 kcal/mol). Hydroxyl Radical 15-23 carbonic anhydrase 2 Homo sapiens 214-218 8262987-4 1993 The side chain hydroxyl group causes: stabilization of zinc-hydroxide relative to zinc-water (pKa increases approximately 2 units); stabilization of the transition state for bicarbonate dehydration relative to the CAII.HCO3- complex (approximately 5 kcal/mol); and destabilization of the CAII.HCO3- complex (approximately 0.8 kcal/mol). Hydroxyl Radical 15-23 carbonic anhydrase 2 Homo sapiens 288-292 8375511-3 1993 Here we show that bilirubin (BR), the end-product of heme catabolism, when bound to bovine serum albumin (BSA), is oxidised by hydroxyl (.OH), hydroperoxyl (HO2.), and superoxide anion (O2-.) Hydroxyl Radical 127-135 albumin Homo sapiens 91-104 8284091-5 1993 Glutathione and 3-aminobenzamide, an inhibitor of poly-ADP-ribose polymerase, partly prevented the nucleotide depletion (adenine nucleotide radioactivity 15 +/- 6% to 33 +/- 13% of total), but scavengers of the hydroxyl radical, dimethylthiourea and DMSO, as well as vitamins E and C, were without effect. Hydroxyl Radical 211-227 poly(ADP-ribose) polymerase 1 Homo sapiens 50-76 8495193-4 1993 C4A binds more efficiently than C4B to amino groups, and C4B is more effective than C4A in binding to hydroxyl groups. Hydroxyl Radical 102-110 complement C4B (Chido blood group) Homo sapiens 57-60 8214084-6 1993 The decrease in ACE activity was also inhibited by the hydroxyl radical scavenger dimethylthiourea (5 mM) but not mannitol (5 mM), which does not cross cell membranes. Hydroxyl Radical 55-71 angiotensin I converting enzyme Bos taurus 16-19 8214084-9 1993 These results suggest that PMN-mediated ACE dysfunction may be due to the production of hydrogen peroxide by PMN and its subsequent conversion into hydroxyl radicals. Hydroxyl Radical 148-165 angiotensin I converting enzyme Bos taurus 40-43 8260935-1 1993 When bovine serum albumin was exposed to the hydroxyl radical generating system of ascorbate-EDTA-Fe3+ or ascorbate-EDTA-Fe(3+)-H2O2, carbonyl formation occurred. Hydroxyl Radical 45-61 albumin Homo sapiens 12-25 8403214-6 1993 These data suggest that increased concentrations of Fe and Cu and decreased levels of Cu,Zn-SOD may facilitate the Fenton reaction to produce hydroxyl radicals in the tissues of the LEC rat. Hydroxyl Radical 142-159 superoxide dismutase 1 Rattus norvegicus 86-95 8353134-5 1993 Reactions of 3-hydroxykynurenine and kynurenine with hydroxyl radicals proceed with diffusion controlled rate constants (1.2 x 10(10) M-1 s-1 and 1.3 x 10(10) M-1 s-1, respectively). Hydroxyl Radical 53-70 myoregulin Homo sapiens 134-147 8374038-2 1993 Bovine serum albumin was reacted with hydroxyl radicals generated via a Fenton-like mechanism or by a radiolysis mechanism. Hydroxyl Radical 38-55 albumin Homo sapiens 7-20 8225024-2 1993 Both methods provided comparable data on temperature-dependent kinetics of superoxide radical formation, but hydroxyl radicals were also detected in spin-trapping experiments. Hydroxyl Radical 109-126 spindlin 1 Homo sapiens 149-153 8406685-10 1993 In contrast to what has been reported earlier, HOCl/MPO only depolymerizes purified umbilical cord HA (in a hydroxyl radical-dependent manner) but does not depolymerize HA in SF. Hydroxyl Radical 108-124 myeloperoxidase Homo sapiens 52-55 8406685-11 1993 As a matter of fact, HOCl/MPO has a scavenging action on SF HA by consuming H2O2 and thus preventing the formation of reactive hydroxyl radicals. Hydroxyl Radical 127-144 myeloperoxidase Homo sapiens 26-29 8349109-1 1993 The enzyme catalase protects aerobic organisms from oxygen-free radical damage by converting hydrogen peroxide to molecular oxygen and water before it can decompose to form the highly reactive hydroxyl radical. Hydroxyl Radical 193-209 Catalase Drosophila melanogaster 11-19 8393194-6 1993 These results indicate that both SH- and non-SH-containing ACE inhibitors scavenge hydroxyl radical more strongly than the superoxide anion radical and that the free radical scavenging action of ACE inhibitors is probably not related only to the presence of the SH radical. Hydroxyl Radical 83-99 angiotensin I converting enzyme Homo sapiens 59-62 8395934-0 1993 Formation of a hydroxyl radical by the myeloperoxidase-NADH-oxygen system. Hydroxyl Radical 15-31 myeloperoxidase Homo sapiens 39-54 8395934-4 1993 The tyrosine formation by the MPO-NADH system was greatly reduced under anaerobic conditions, and significantly inhibited by hydroxyl radical scavengers. Hydroxyl Radical 125-141 myeloperoxidase Homo sapiens 30-33 8390261-5 1993 Using spin trapping/ESR spectroscopy, NPC 15669 was found to inhibit myeloperoxidase (MPO)-dependent hydroxyl radical primarily by scavenging hypochlorous acid, and secondarily by inhibiting agonist-stimulated degranulation as assessed by MPO and elastase release. Hydroxyl Radical 101-117 myeloperoxidase Homo sapiens 69-84 8390261-5 1993 Using spin trapping/ESR spectroscopy, NPC 15669 was found to inhibit myeloperoxidase (MPO)-dependent hydroxyl radical primarily by scavenging hypochlorous acid, and secondarily by inhibiting agonist-stimulated degranulation as assessed by MPO and elastase release. Hydroxyl Radical 101-117 myeloperoxidase Homo sapiens 86-89 8495193-4 1993 C4A binds more efficiently than C4B to amino groups, and C4B is more effective than C4A in binding to hydroxyl groups. Hydroxyl Radical 102-110 complement C4A (Rodgers blood group) Homo sapiens 84-87 8382368-3 1993 To characterize the reactivity of DNA with the hydroxyl radical, we investigated the variation of the G value for SSBs [G(SSB)] with the concentration of added hydroxyl radical scavengers. Hydroxyl Radical 47-63 small RNA binding exonuclease protection factor La Homo sapiens 114-117 8382368-3 1993 To characterize the reactivity of DNA with the hydroxyl radical, we investigated the variation of the G value for SSBs [G(SSB)] with the concentration of added hydroxyl radical scavengers. Hydroxyl Radical 160-176 small RNA binding exonuclease protection factor La Homo sapiens 114-117 8382369-3 1993 To characterize the reactivity of the SV40 minichromosome with the hydroxyl radical and to compare its behavior with that of naked DNA, we examined the variation of the G value for SSB formation, G(SSB), with the concentration of added hydroxyl radical scavengers. Hydroxyl Radical 236-252 small RNA binding exonuclease protection factor La Homo sapiens 181-184 8380162-8 1993 In the xanthine/xanthine oxidase model, the combination of SOD and Fe2+ results in an enhanced production of hydroxyl radicals which is inhibited by the inclusion of catalase. Hydroxyl Radical 109-126 catalase Rattus norvegicus 166-174 8386688-0 1993 The effects of myoglobin and apomyoglobin on the formation and stability of the hydroxyl radical adduct of 5,5"-dimethyl-1-pyrroline-N-oxide. Hydroxyl Radical 80-96 myoglobin Homo sapiens 15-24 8357331-4 1993 Although earlier studies suggested that sulfhydryl-containing ACE inhibitors scavenge superoxide anions, recent data have shown that these drugs scavenge hydroxyl radical and hypochlorous acid with no effect on superoxide anion. Hydroxyl Radical 154-170 angiotensin I converting enzyme Canis lupus familiaris 62-65 8386688-4 1993 From the evidence of these and other experiments it was concluded that the DMPO-OH adduct reacts with hydrogen peroxide and myoglobin to give non-paramagnetic products, and hence that the use of the DMPO spin trap to detect hydroxyl or other active radicals in systems containing physiological concentrations of myoglobin may give misleading results. Hydroxyl Radical 224-232 myoglobin Homo sapiens 124-133 8386688-4 1993 From the evidence of these and other experiments it was concluded that the DMPO-OH adduct reacts with hydrogen peroxide and myoglobin to give non-paramagnetic products, and hence that the use of the DMPO spin trap to detect hydroxyl or other active radicals in systems containing physiological concentrations of myoglobin may give misleading results. Hydroxyl Radical 224-232 myoglobin Homo sapiens 312-321 8244086-1 1993 The authors have compared the ability of two non-SH-containing angiotensin converting enzyme (ACE) inhibitors (enalaprilat and lisinopril) with an -SH containing ACE inhibitor (captopril) to scavenge the hydroxyl radical (.OH). Hydroxyl Radical 204-220 angiotensin I converting enzyme Homo sapiens 162-165 8397147-1 1993 The reactions of cerium(IV) and the hydroxyl radical [generated from iron(ii)/H2O2] with bovine serum albumin (BSA) have been investigated by EPR spin trapping. Hydroxyl Radical 36-52 albumin Homo sapiens 96-115 1343848-3 1992 Hydroxyl radical spin-adducts were detected under conditions of both extracellular and intracellular photosensitization. Hydroxyl Radical 0-16 spindlin 1 Homo sapiens 17-21 8397147-5 1993 A similar transfer pathway can be observed when hydroxyl radicals react with BSA. Hydroxyl Radical 48-65 albumin Homo sapiens 77-80 8397147-6 1993 Further experiments demonstrate that the reverse process can also occur: when hydroxyl radicals react with BSA, the thiol group appears to act as a radical sink and protects the protein from denaturation and fragmentation through the transfer of damage from a carbon site to the thiol group. Hydroxyl Radical 78-95 albumin Homo sapiens 107-110 8439407-7 1993 For example, we observed a 50% to 75% reduction in the specific activities of type II cell superoxide dismutase, catalase, and glutathione peroxidase, all critical scavengers of cell superoxide and hydrogen peroxide and key enzymes in the attenuation of hydroxyl radical formation. Hydroxyl Radical 254-270 catalase Homo sapiens 113-121 1334093-0 1992 Hydroxyl radical production by H2O2 plus Cu,Zn-superoxide dismutase reflects the activity of free copper released from the oxidatively damaged enzyme. Hydroxyl Radical 0-16 superoxide dismutase 1 Homo sapiens 41-67 1334093-1 1992 To elaborate the catalytic activity of Cu2+ of Cu,Zn-superoxide dismutase (SOD) in the generation of hydroxyl radical (.OH) from H2O2, we investigated the mechanism of inactivation of alpha 1-protease inhibitor (alpha 1-PI), mediated by H2O2 and Cu,Zn-SOD. Hydroxyl Radical 101-117 superoxide dismutase 1 Homo sapiens 47-73 1334093-1 1992 To elaborate the catalytic activity of Cu2+ of Cu,Zn-superoxide dismutase (SOD) in the generation of hydroxyl radical (.OH) from H2O2, we investigated the mechanism of inactivation of alpha 1-protease inhibitor (alpha 1-PI), mediated by H2O2 and Cu,Zn-SOD. Hydroxyl Radical 101-117 superoxide dismutase 1 Homo sapiens 75-78 1337312-0 1992 Oxidative damage to bovine serum albumin induced by hydroxyl radical generating systems of xanthine oxidase + EDTA-Fe3+ and ascorbate + EDTA-Fe3+. Hydroxyl Radical 52-68 albumin Homo sapiens 27-40 1337312-1 1992 Oxidative damage to bovine serum albumin (BSA) was induced by hydroxyl radical (HO.) Hydroxyl Radical 62-78 albumin Homo sapiens 27-40 1322662-8 1992 Several other coumarins with one or more hydroxyl substituents were also capable of effectively removing superoxide anions (IC50 3.7-72 microM), although some could not be quantified due to direct rapid reduction of cytochrome c. Hydroxyl Radical 41-49 cytochrome c, somatic Homo sapiens 216-228 1324689-3 1992 The addition of catalase produced a significant inhibitory effect on the cytotoxicity of two representative compounds, indicating that the cytotoxic action is mediated by the generation of H2O2, which may yield hydroxyl radicals via various mechanisms. Hydroxyl Radical 211-228 catalase Homo sapiens 16-24 1411581-3 1992 MMP-8 is activated by hypochlorous acid produced by myeloperoxidase from hydrogen peroxide and chloride ion and by the hydroxyl radical produced in Haber Weiss reaction fed by superoxide produced by, eg, NADPH (reduced nicotinamide adenine dinucleotide) oxidase and xanthine oxidase. Hydroxyl Radical 119-135 matrix metallopeptidase 8 Homo sapiens 0-5 1329770-3 1992 By comparing the I50 values of flavonoids from different classes possessing an identical hydroxyl configuration, we determined the following order of potency for inhibition of GR: anthocyanidin > dihydroflavonol = chalcone > flavonol > catechin. Hydroxyl Radical 89-97 glutathione-disulfide reductase Homo sapiens 176-178 1639779-8 1992 Examination of the rat DHPR sequence shows a typical dinucleotide binding fold with Asp-37 located precisely in the position predicted for the acidic residue that participates in hydrogen bond formation with the 2"-hydroxyl moiety of all known NAD-dependent dehydrogenases. Hydroxyl Radical 215-223 quinoid dihydropteridine reductase Rattus norvegicus 23-27 1509687-4 1992 In ancillary in vitro experiments with a paraquat-based free radical system, where glutathione reductase and NADPH were used as sources of enzymic activity for the redox cycling of paraquat, desferrioxamine effectively prevented the formation of hydroxyl radicals, as determined by deoxyribose degradation. Hydroxyl Radical 246-263 glutathione-disulfide reductase Rattus norvegicus 83-104 1333457-4 1992 The level of CL inhibition with Am plus the hydroxyl radical scavengers allopurinol, dimethyl sulfoxide (DMSO) or superoxide dismutase (SOD) is greater than that with Am alone. Hydroxyl Radical 44-60 superoxide dismutase 1 Homo sapiens 136-139 1321617-4 1992 The results lead to the conclusion that the hydroxyl radical formed in Fe(II)-elsamicin A plus dithiothreitol system oxidizes the deoxyribose moiety via hydrogen abstraction predominantly at the C-4" carbon of the deoxyribose backbone and ultimately produces strand breakage of DNA. Hydroxyl Radical 44-60 complement C4A (Rodgers blood group) Homo sapiens 195-198 1319498-12 1992 Hydroxyl radical footprinting showed that the breakdown pattern of DNA at saturating DBP concentrations is much more regular than the protein-free DNA. Hydroxyl Radical 0-16 zinc finger protein 763 Homo sapiens 85-88 1322166-3 1992 Our results indicate that mitochondrial respiration chains are damaged by a hydroxyl radical at an early stage of the cell lysis after TNF treatment. Hydroxyl Radical 76-92 tumor necrosis factor Mus musculus 135-138 1314821-3 1992 Hydroxyl radical formation was inhibited by treatment with superoxide dismutase, catalase, and azide. Hydroxyl Radical 0-16 catalase Homo sapiens 81-89 1320745-8 1992 Therefore, it is possible to hypothesize that an electron leakage at the level of the auto-oxidizing chain components (i.e., cytochrome b and ubiquinone populations) increases the release of activated oxygen species (superoxide radical, hydroxyl radical). Hydroxyl Radical 237-253 cytochrome b, mitochondrial Rattus norvegicus 125-137 1314821-0 1992 Spin trapping evidence for myeloperoxidase-dependent hydroxyl radical formation by human neutrophils and monocytes. Hydroxyl Radical 53-69 spindlin 1 Homo sapiens 0-4 1314821-0 1992 Spin trapping evidence for myeloperoxidase-dependent hydroxyl radical formation by human neutrophils and monocytes. Hydroxyl Radical 53-69 myeloperoxidase Homo sapiens 27-42 1314821-1 1992 Using the electron spin resonance/spin trapping system, 4-pyridyl 1-oxide N-tert-butylnitrone (4-POBN)/ethanol, hydroxyl radical was detected as the alpha-hydroxyethyl spin trapped adduct of 4-POBN, 4-POBN-CH(CH3)OH, from phorbol 12-myristate 13-acetate-stimulated human neutrophils and monocytes without the addition of supplemental iron. Hydroxyl Radical 112-128 spindlin 1 Homo sapiens 19-23 1314821-1 1992 Using the electron spin resonance/spin trapping system, 4-pyridyl 1-oxide N-tert-butylnitrone (4-POBN)/ethanol, hydroxyl radical was detected as the alpha-hydroxyethyl spin trapped adduct of 4-POBN, 4-POBN-CH(CH3)OH, from phorbol 12-myristate 13-acetate-stimulated human neutrophils and monocytes without the addition of supplemental iron. Hydroxyl Radical 112-128 spindlin 1 Homo sapiens 34-38 1314821-1 1992 Using the electron spin resonance/spin trapping system, 4-pyridyl 1-oxide N-tert-butylnitrone (4-POBN)/ethanol, hydroxyl radical was detected as the alpha-hydroxyethyl spin trapped adduct of 4-POBN, 4-POBN-CH(CH3)OH, from phorbol 12-myristate 13-acetate-stimulated human neutrophils and monocytes without the addition of supplemental iron. Hydroxyl Radical 112-128 spindlin 1 Homo sapiens 34-38 1577792-5 1992 Nonpolar residues normally present in rhodopsin and in the green pigment were substituted by hydroxyl-bearing residues normally present in the red pigment. Hydroxyl Radical 93-101 rhodopsin Homo sapiens 38-47 1316727-7 1992 Ceruloplasmin that was present in the BALF and serum samples had functional oxidase activity, and purified human ceruloplasmin inhibited hydroxyl radical formation by phorbol myristate acetate (PMA)-stimulated neutrophils. Hydroxyl Radical 137-145 ceruloplasmin Homo sapiens 113-126 1314821-6 1992 Detection of hydroxyl radical from stimulated monocyte-derived macrophages, which lack myeloperoxidase, required the addition of supplemental iron. Hydroxyl Radical 13-29 myeloperoxidase Homo sapiens 87-102 1314821-7 1992 The addition of purified myeloperoxidase to an enzymatic superoxide generating system resulted in the detection of hydroxyl radical that was dependent upon the presence of chloride and was inhibited by superoxide dismutase, catalase, and azide. Hydroxyl Radical 115-131 myeloperoxidase Homo sapiens 25-40 1314821-7 1992 The addition of purified myeloperoxidase to an enzymatic superoxide generating system resulted in the detection of hydroxyl radical that was dependent upon the presence of chloride and was inhibited by superoxide dismutase, catalase, and azide. Hydroxyl Radical 115-131 catalase Homo sapiens 224-232 1314821-9 1992 4-POBN-CH(CH3)OH was not observed upon stimulation of myeloperoxidase-deficient neutrophils, whereas addition of myeloperoxidase to the reaction mixture resulted in the detection of hydroxyl radical. Hydroxyl Radical 182-198 myeloperoxidase Homo sapiens 113-128 1314821-10 1992 These results support the ability of human neutrophils and monocytes to generate hydroxyl radical through a myeloperoxidase-dependent mechanism. Hydroxyl Radical 81-97 myeloperoxidase Homo sapiens 108-123 1550349-10 1992 The antioxidants mannitol and benzoate, as well as the iron chelator deferoxamine, reduced the extent of TNF alpha-induced oxidant effects in hepatocytes, which indicates that the oxidant stress may involve hydroxyl radical generation. Hydroxyl Radical 207-223 tumor necrosis factor Mus musculus 105-114 1372530-8 1992 Hydroxyl radicals may play a role in the induction mechanism since dimethyl sulfoxide, a radical scavenger, blocked the radiation-mediated increase in MGMT. Hydroxyl Radical 0-17 O-6-methylguanine-DNA methyltransferase Rattus norvegicus 151-155 1325381-2 1992 Purified (Na+ + K+)-ATPase was irreversibly inhibited upon exposure to hydrogen peroxide, the superoxide anion, and the hydroxyl radical. Hydroxyl Radical 120-136 dynein axonemal heavy chain 8 Homo sapiens 20-26 1621952-2 1992 It can be synthesized either chemically or enzymatically using galactose oxidase to oxidize the hydroxyl moiety at C-6 to an aldehyde (6-aldo-UDP-Gal), which is then reduced back to the alcohol with tritiated sodium borohydride. Hydroxyl Radical 96-104 complement C6 Homo sapiens 115-118 1311584-0 1992 NAD(P)H (quinone acceptor) oxidoreductase (DT-diaphorase)-mediated two-electron reduction of anthraquinone-based antitumour agents and generation of hydroxyl radicals. Hydroxyl Radical 149-166 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 43-56 1540207-3 1992 Attack of hydroxyl radicals generated by the Cu (II)/ascorbate system upon Leu-enkephalin also produces isomeric o-, m- and p-hydroxy-phenylalanyl derivatives. Hydroxyl Radical 10-27 prodynorphin Homo sapiens 75-89 1317004-5 1992 In the presence of H2O2, all the forms of vanadate were able to oxidize reduced cytochrome c, which was sensitive to mannitol, tris and also catalase, indicating H2O2-dependent generation of hydroxyl radicals. Hydroxyl Radical 191-208 cytochrome c, somatic Homo sapiens 80-92 1377792-5 1992 Unlike other amidated peptides, MPA might be generated from MBP by hydroxyl radicals produced via a Fenton reaction in situ. Hydroxyl Radical 67-84 myelin basic protein Bos taurus 60-63 1375053-7 1992 Electron spin resonance measurements provide evidence for the formation of long-lived Cr5+ intermediates in the reduction of Cr6+ by glutathione reductase in the presence of NADPH and for the hydroxyl radical formation during the glutathione reductase catalyzed reduction of Cr6+. Hydroxyl Radical 192-208 glutathione-disulfide reductase Rattus norvegicus 230-251 1370822-6 1992 Purified quinone acceptor oxidoreductase in combination with MD resulted in the production of significant levels of the hydroxyl radical as measured by ESR. Hydroxyl Radical 120-136 thioredoxin reductase 1 Homo sapiens 26-40 1316115-4 1992 Degradation of MeHg and EtHg with the myeloperoxidase (MPO)-H2O2-chloride system was inhibited by MPO inhibitors (cyanide and azide), catalase, hypochlorous acid (HOCI) scavengers (glycine, alanine, serine and taurine), 1,4-diazabicyclo[2,2,2]octane and 2,5-dimethylfuran, but not by hydroxyl radical scavengers (ethanol and mannitol). Hydroxyl Radical 284-300 myeloperoxidase Homo sapiens 38-53 1316115-4 1992 Degradation of MeHg and EtHg with the myeloperoxidase (MPO)-H2O2-chloride system was inhibited by MPO inhibitors (cyanide and azide), catalase, hypochlorous acid (HOCI) scavengers (glycine, alanine, serine and taurine), 1,4-diazabicyclo[2,2,2]octane and 2,5-dimethylfuran, but not by hydroxyl radical scavengers (ethanol and mannitol). Hydroxyl Radical 284-300 myeloperoxidase Homo sapiens 55-58 1316115-4 1992 Degradation of MeHg and EtHg with the myeloperoxidase (MPO)-H2O2-chloride system was inhibited by MPO inhibitors (cyanide and azide), catalase, hypochlorous acid (HOCI) scavengers (glycine, alanine, serine and taurine), 1,4-diazabicyclo[2,2,2]octane and 2,5-dimethylfuran, but not by hydroxyl radical scavengers (ethanol and mannitol). Hydroxyl Radical 284-300 myeloperoxidase Homo sapiens 98-101 1310595-7 1992 In all the above respects, SIN-1 mimicked the production of hydroxyl radicals from the ascorbate-driven Fenton reaction. Hydroxyl Radical 60-77 MAPK associated protein 1 Homo sapiens 27-32 1310595-9 1992 SIN-1 produces an oxidant with the properties of the hydroxyl radical by a mechanism clearly different to that of the Fenton reaction. Hydroxyl Radical 53-69 MAPK associated protein 1 Homo sapiens 0-5 1310595-10 1992 We conclude that the simultaneous production of NO and superoxide from SIN-1 results in the formation of hydroxyl radicals. Hydroxyl Radical 105-122 MAPK associated protein 1 Homo sapiens 71-76 1317327-4 1992 Exposure of bovine serum albumin (BSA) (0.5 mg/mL) to pMC540 (0.2 mg/mL-1 mg/mL) results in loss of tryptophan fluorescence and 345 nm emission, suggesting a probable role of either hydroxyl (.OH) or .OH + superoxide (O2-). Hydroxyl Radical 182-190 albumin Homo sapiens 19-32 1316186-9 1992 In the presence of ethylenediamine, Co(II) bound molecular O2 and directly oxidized DMPO to its DMPO/.OH adduct without first forming free superoxide, hydroxyl radical, or hydrogen peroxide. Hydroxyl Radical 151-167 mitochondrially encoded cytochrome c oxidase II Homo sapiens 36-42 1332919-5 1992 SIN-1 liberates both superoxide and nitric oxide during autooxidation resulting in the formation of hydroxyl radicals. Hydroxyl Radical 100-117 MAPK associated protein 1 Homo sapiens 0-5 1939152-2 1991 The complex of Xenopus transcription factor IIIA (TFIIIA) with 5 S rRNA was analyzed in nuclease protection experiments using hydroxyl radical. Hydroxyl Radical 126-142 general transcription factor 3A L homeolog Xenopus laevis 50-56 18475484-1 1992 Substance P (SP(1-11)) was exposed to a continuous flux of superoxide (O2-) or hydroxyl radicals ((. Hydroxyl Radical 79-96 tachykinin precursor 1 Homo sapiens 0-11 1748819-3 1991 Hydrogen peroxide functions as a reversible inhibitor of human tyrosinase with a KI of 8 X 10(-6) M. Also, hydrogen peroxide undergoes photochemical reduction yielding highly reactive hydroxyl radicals (OH.) Hydroxyl Radical 184-201 tyrosinase Homo sapiens 63-73 1665882-2 1991 Today there are four major arguments for such a role in IBD: Infiltration of the inflamed intestinal mucosa with myeloperoxidase containing activated neutrophils able to produce superoxide, hydroxyl and hypochlorite, increased chemoluminescence response of peripheral and mucosal phagocytic cells to various stimuli, decreased inflammation following specific scavenger treatment in animal models of colitis and defined radical scavenger and inhibitory properties of drugs, especially aminosalicylates used in the therapy of IBD. Hydroxyl Radical 190-198 myeloperoxidase Homo sapiens 113-128 1682068-11 1991 H2O2-induced PMN retention was completely inhibited by addition of catalase or the hydroxyl radical scavenger dimethylthiourea to the perfusate by incubation of the PMN with a monoclonal antibody (Mab) against CD18 (R15.7) or by perfusion of the H2O2-treated vessel with CL18/6, a Mab against canine ICAM-1 (intercellular adhesion molecule-1). Hydroxyl Radical 83-99 intercellular adhesion molecule 1 Canis lupus familiaris 300-306 1682068-11 1991 H2O2-induced PMN retention was completely inhibited by addition of catalase or the hydroxyl radical scavenger dimethylthiourea to the perfusate by incubation of the PMN with a monoclonal antibody (Mab) against CD18 (R15.7) or by perfusion of the H2O2-treated vessel with CL18/6, a Mab against canine ICAM-1 (intercellular adhesion molecule-1). Hydroxyl Radical 83-99 intercellular adhesion molecule 1 Canis lupus familiaris 308-341 1659450-2 1991 We noted that in contrast to results with other hydroxyl radical detection systems, superoxide dismutase (SOD) often increased the amount of hydroxyl radical-derived spin adducts of 5,5-dimethyl-1-pyrroline N-oxide (DMPO) produced by the reaction of hypoxanthine, xanthine oxidase and iron. Hydroxyl Radical 48-64 superoxide dismutase 1 Homo sapiens 84-104 1933852-9 1991 Partial inhibition of product formation indicated a possible "site-specific" formation of hydroxyl radical by unchelated Ni(II) and Co(II) ions bound to chromatin. Hydroxyl Radical 90-106 mitochondrially encoded cytochrome c oxidase II Homo sapiens 132-138 1659450-2 1991 We noted that in contrast to results with other hydroxyl radical detection systems, superoxide dismutase (SOD) often increased the amount of hydroxyl radical-derived spin adducts of 5,5-dimethyl-1-pyrroline N-oxide (DMPO) produced by the reaction of hypoxanthine, xanthine oxidase and iron. Hydroxyl Radical 48-64 superoxide dismutase 1 Homo sapiens 106-109 1659450-2 1991 We noted that in contrast to results with other hydroxyl radical detection systems, superoxide dismutase (SOD) often increased the amount of hydroxyl radical-derived spin adducts of 5,5-dimethyl-1-pyrroline N-oxide (DMPO) produced by the reaction of hypoxanthine, xanthine oxidase and iron. Hydroxyl Radical 141-157 superoxide dismutase 1 Homo sapiens 84-104 1659450-2 1991 We noted that in contrast to results with other hydroxyl radical detection systems, superoxide dismutase (SOD) often increased the amount of hydroxyl radical-derived spin adducts of 5,5-dimethyl-1-pyrroline N-oxide (DMPO) produced by the reaction of hypoxanthine, xanthine oxidase and iron. Hydroxyl Radical 141-157 superoxide dismutase 1 Homo sapiens 106-109 1712900-4 1991 In addition, the use of hydroxyl radicals, as RNA-cleaving reagents, has revealed four distinct regions in this domain that are in close contact with SRP9/14. Hydroxyl Radical 24-41 signal recognition particle 9 Homo sapiens 150-154 1657926-3 1991 Hydroxyl radical footprints show that the transposase binds to one face of the DNA helix and covers two consecutive major grooves. Hydroxyl Radical 0-16 Mu transposase C-terminal domain-containing protein Escherichia phage Mu 42-53 1655409-7 1991 The protection at the L1 and R1 sites extends 12-13 bp beyond the Mu-host junctions as seen by DNase I and methidiumpropyl-EDTA.Fe(II) [MPE.Fe(II)] foot-printing, indicating Mu A contacts with the flanking host sequences in the transpososome but not on linear DNA; furthermore, hydroxyl radical footprinting shows an unprecedentedly large enhancement on the continuous strand, 2 bp beyond the nick site outside the Mu right end, which suggests that an altered DNA structure is induced upon Type 1 complex formation. Hydroxyl Radical 278-294 L1 cell adhesion molecule Homo sapiens 22-31 1655825-4 1991 Hydroxyl radical formation was only detected with pseudomonas elastase treated diferrictransferrin and, to a much lesser extent, diferriclactoferrin. Hydroxyl Radical 0-16 elastase, neutrophil expressed Homo sapiens 62-70 1655825-6 1991 Addition of pseudomonas elastase-treated diferrictransferrin to stimulated neutrophils also resulted in hydroxyl radical generation. Hydroxyl Radical 104-120 elastase, neutrophil expressed Homo sapiens 24-32 1655825-7 1991 Incubation of pseudomonas elastase with transferrin which had been selectively iron loaded at either the NH2- or COOH-terminal binding site yielded iron chelates with similar efficacy for hydroxyl radical catalysis. Hydroxyl Radical 188-196 elastase, neutrophil expressed Homo sapiens 26-34 1655825-8 1991 Pseudomonas elastase and HOCl treatment also decreased the ability of apotransferrin to inhibit hydroxyl radical formation by a Fe-NTA supplemented hypoxanthine/xanthine oxidase system. Hydroxyl Radical 96-112 elastase, neutrophil expressed Homo sapiens 12-20 1656946-4 1991 By inhibiting erythrocyte superoxide dismutase, catalase, and glutathione peroxidase with N,N-diethyldithiocarbamate or sodium cyanide, we demonstrate the light-dependent generation of hydroxyl radical in human erythrocytes using spin trapping/Electron Spin Resonance spectroscopy. Hydroxyl Radical 185-201 catalase Homo sapiens 48-56 1757317-5 1991 These effects were prevented by a mixture of superoxide dismutase and catalase or by sodium salicylate, which removes hydroxyl radicals from solution after electrolysis. Hydroxyl Radical 118-135 catalase Oryctolagus cuniculus 70-78 1877661-6 1991 Vasodilation to all activated oxygen species was largely reversible with only the hydroxyl radical encouraging combination of xanthine oxidase, hypoxanthine, H2O2, and FeCl3, causing significant dilation 20 min after removal of treatment. Hydroxyl Radical 82-98 xanthine dehydrogenase Sus scrofa 126-142 1663741-5 1991 Catalase inhibited both Fe(2+)-H2O2 induced oxalate binding and lipid peroxidation reactions, suggesting that the induced oxalate binding in mitochondria was mediated through the hydroxyl radical reaction mechanism. Hydroxyl Radical 179-187 catalase Rattus norvegicus 0-8 1652585-7 1991 The DMPO-OH signal decreased on addition of superoxide dismutase, catalase, or diethylenetriaminepentaacetic acid, indicating that the hydroxyl radical was generated via the metal-catalyzed Haber-Weiss reaction from the superoxide radical and hydrogen peroxide. Hydroxyl Radical 135-151 catalase Homo sapiens 66-74 1654773-3 1991 The effect of H2O2 and the hydroxyl radical (.OH) on fibronectin was investigated. Hydroxyl Radical 27-43 fibronectin 1 Homo sapiens 53-64 1649598-2 1991 As assessed by SDS/PAGE, the hydroxyl radicals (.OH) caused the disappearance of the protein band at 12 kDa that represents beta 2m, and cross-linked the protein into protein bands stable to both SDS and reducing conditions. Hydroxyl Radical 29-46 beta-2-microglobulin Homo sapiens 124-131 1665058-4 1991 M-1 also scavenged the hydroxyl radical as did bifemelane hydrochloride. Hydroxyl Radical 23-39 myoregulin Homo sapiens 0-3 1849423-10 1991 The proposed model of ZFY is supported in part by the hydroxyl radical footprint of the TFIIIA-DNA complex [Churchill, M.E.A., Tullius, T.D., & Klug, A. Hydroxyl Radical 54-70 zinc finger protein Y-linked Homo sapiens 22-25 1665838-5 1991 Damage can be prevented by scavengers of the hydroxyl radical such as mannitol, formate the thiourea, by catalase and by the protein caeruloplasmin, suggesting that Fenton chemistry occurs leading to the formation of hydroxyl radicals. Hydroxyl Radical 45-61 catalase Homo sapiens 105-113 2001413-1 1991 Conversion of xanthine dehydrogenase (XDH) to xanthine oxidase (XO) and the toxic reactions of subsequent XO-derived superoxide, hydrogen peroxide and hydroxyl radical, have been suggested to be critical factors in several mechanisms of tissue pathophysiology. Hydroxyl Radical 151-167 xanthine dehydrogenase Rattus norvegicus 14-36 2001413-1 1991 Conversion of xanthine dehydrogenase (XDH) to xanthine oxidase (XO) and the toxic reactions of subsequent XO-derived superoxide, hydrogen peroxide and hydroxyl radical, have been suggested to be critical factors in several mechanisms of tissue pathophysiology. Hydroxyl Radical 151-167 xanthine dehydrogenase Rattus norvegicus 38-41 1991211-7 1991 The results are discussed in the light of earlier suggestions that the TfC2 subtype confers an increased risk of cellular damage by enhancing hydroxyl radical formation, although it is possible that there exists a genetic linkage of Tf variant to some other locus which is influencing susceptibility to RA. Hydroxyl Radical 142-158 transferrin Homo sapiens 71-73 1899491-11 1991 Pretreatment with the hydroxyl radical scavenger dimethylthiourea, 1 gm/kg, intravenously, (n = 6) prevented the interleukin-2-induced increase in mean pulmonary artery pressure, lung lymph flow, lymph/plasma protein ration, lymph protein clearance, and thromboxane B2 levels in plasma and lung lymph. Hydroxyl Radical 22-38 interleukin-2 Ovis aries 113-126 2006602-10 1991 The hydroxyl radical scavenger dimethylsulfoxide abolished the increase in Ptp and attenuated the increase in Ppa, but did not consistently protect the lungs from edema development. Hydroxyl Radical 4-20 protein tyrosine phosphatase, non-receptor type 1 Rattus norvegicus 75-78 1649085-4 1991 Furthermore, neutrophil lactoferrin and myeloperoxidase limit the magnitude (and in the case of lactoferrin the duration) of hydroxyl radical formed by neutrophils in an iron catalyzed system. Hydroxyl Radical 125-141 lactotransferrin Homo sapiens 13-35 1649085-4 1991 Furthermore, neutrophil lactoferrin and myeloperoxidase limit the magnitude (and in the case of lactoferrin the duration) of hydroxyl radical formed by neutrophils in an iron catalyzed system. Hydroxyl Radical 125-141 myeloperoxidase Homo sapiens 40-55 1646469-3 1991 The addition of the enzymes superoxide dismutase (SOD) and catalase (which do not permeate the cell membrane), reduced the amount of hydroxyl radicals detected. Hydroxyl Radical 133-150 catalase Homo sapiens 59-67 1646469-4 1991 SOD decreased hydroxyl radicals somewhat but catalase eliminated hydroxyl radicals almost completely. Hydroxyl Radical 65-82 catalase Homo sapiens 45-53 1646469-8 1991 Moreover, the ability of SOD or catalase to eliminate hydroxyl radical activity correlated inversely with leukemic cell differentiation. Hydroxyl Radical 54-70 catalase Homo sapiens 32-40 1661698-2 1991 The reactions of hydroxyl radicals generated from FeII/H2O2 and CuII/H2O2 redox couples with a variety of proteins (BSA, histones, cytochrome c, lysozyme and protamine) have been investigated by e.s.r. Hydroxyl Radical 17-34 cytochrome c, somatic Homo sapiens 131-143 1665838-5 1991 Damage can be prevented by scavengers of the hydroxyl radical such as mannitol, formate the thiourea, by catalase and by the protein caeruloplasmin, suggesting that Fenton chemistry occurs leading to the formation of hydroxyl radicals. Hydroxyl Radical 217-234 catalase Homo sapiens 105-113 2172172-0 1990 Suppressive effects of intracellular glutathione on hydroxyl radical production induced by tumor necrosis factor. Hydroxyl Radical 52-68 tumor necrosis factor Homo sapiens 91-112 2175361-4 1990 Whereas the HSE1-associated factor binds tightly within the major groove of DNA, as discerned by protection of guanine residues from methylation by dimethyl sulfate in intact cells, the TATA factor appears to bind principally to the sugar-phosphate backbone, as revealed by strong protection from hydroxyl radical cleavage in whole-cell lysates. Hydroxyl Radical 297-313 ESCRT-0 subunit protein HSE1 Saccharomyces cerevisiae S288C 12-16 2175361-7 1990 Protein binding to HSE1 appears to cause a non-B-conformation, on the basis of a local 12 base-pair periodicity of hydroxyl radical protection and the presence of multiple DNase I hyperreactive cleavages flanking HSE1, whose pattern changes following heat shock. Hydroxyl Radical 115-131 ESCRT-0 subunit protein HSE1 Saccharomyces cerevisiae S288C 19-23 1714347-3 1990 It was proved by superoxide dismutase (SOD) and catalase that the hydroxyl radicals produced in the stimulated lymphocyte system came from superoxide anions, just like the hydroxyl radicals produced in the stimulated PMN. Hydroxyl Radical 66-83 superoxide dismutase 1 Homo sapiens 17-37 1714347-3 1990 It was proved by superoxide dismutase (SOD) and catalase that the hydroxyl radicals produced in the stimulated lymphocyte system came from superoxide anions, just like the hydroxyl radicals produced in the stimulated PMN. Hydroxyl Radical 66-83 superoxide dismutase 1 Homo sapiens 39-42 2172172-4 1990 The hydroxyl radical production in L-M cells stimulated by TNF was increased by treatment with BSO or DEM. Hydroxyl Radical 4-20 tumor necrosis factor Homo sapiens 59-62 2172172-5 1990 These results are consistent with the suggestion that intracellular GSH exerts its protective function against the cytocidal effect of TNF by inhibiting the hydroxyl radical production stimulated by TNF. Hydroxyl Radical 157-173 tumor necrosis factor Homo sapiens 135-138 2172172-5 1990 These results are consistent with the suggestion that intracellular GSH exerts its protective function against the cytocidal effect of TNF by inhibiting the hydroxyl radical production stimulated by TNF. Hydroxyl Radical 157-173 tumor necrosis factor Homo sapiens 199-202 1963276-2 1990 For superoxide and hydroxyl radical, the spin trap 5,5-dimethyl-1-pyrroline 1-oxide (DMPO) is most frequently used. Hydroxyl Radical 19-35 spindlin 1 Homo sapiens 41-45 2176549-2 1990 While superoxide dismutase was without any effect on the DNA damage, catalase and inhibitors of free hydroxyl radicals inhibited the DNA degradation, indicating that hydroxyl radicals were responsible for this drug-Cu-dependent DNA damage. Hydroxyl Radical 166-183 catalase Homo sapiens 69-77 2173602-7 1990 Thus, these results demonstrate that the SH-containing ACE agents are capable of protecting the endothelial cells against free radical induced lipid peroxidation and cell injury; the mechanism may be due to direct hydroxyl radical scavenging. Hydroxyl Radical 214-230 angiotensin I converting enzyme Homo sapiens 55-58 1980478-3 1990 In contrast to the POU domain, the homeo domain protects only part of the octamer sequence in the Ad2 origin against breakdown by DNase I or hydroxyl radicals. Hydroxyl Radical 141-158 apolipoprotein E Homo sapiens 98-101 2173718-5 1990 generation under basal conditions and during hyperoxia, and provide iron catalysts necessary for hydroxyl radical (.OH) formation and propagation of lipid peroxidation, we postulated that cytochrome P-450 might have a potential role in mediating ischemia-reperfusion injury. Hydroxyl Radical 97-113 cytochrome P-450 Oryctolagus cuniculus 188-204 2176255-2 1990 Cells were exposed to reactive oxygen molecules including superoxide anion, hydrogen peroxide and hydroxyl radical generated by xanthine oxidase and hypoxanthine. Hydroxyl Radical 98-114 xanthine dehydrogenase Sus scrofa 128-144 2171659-1 1990 The Fe3+ complex of ochratoxin A has been shown to produce hydroxyl radicals in the presence of NADPH and NADPH-cytochrome-P-450 reductase. Hydroxyl Radical 59-76 cytochrome p450 oxidoreductase Homo sapiens 106-138 2171659-0 1990 NADPH-cytochrome-P-450 reductase promoted hydroxyl radical production by the iron(III)-ochratoxin A complex. Hydroxyl Radical 42-58 cytochrome p450 oxidoreductase Homo sapiens 0-32 2282081-7 1990 Apparently CP reception on RBC leads not only to membrane protection from superoxide and hydroxyl radicals but represents a more complex process. Hydroxyl Radical 89-106 ceruloplasmin Homo sapiens 11-13 1965278-2 1990 The formation of hydroxyl radical was detected by water-soluble spin-traps, alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone (POBN) and 5,5-dimethyl-1-pyrroline N-oxide (DMPO). Hydroxyl Radical 17-33 spindlin 1 Homo sapiens 64-68 2401073-8 1990 Treatment with recombinant human superoxide dismutase (hSOD, 5 mg/kg/hr, that is, 15,545 SOD units/kg/hr), starting 10 minutes before reperfusion, preserved the vasodilator response to ACh (82 +/- 6%) and A23187, but treatment with the hydroxyl ion scavenger N-(2-mercapto proprionyl)-glycine (MPG) (8 mg/kg/hr) only protected the A23187 response. Hydroxyl Radical 236-244 superoxide dismutase 1 Homo sapiens 55-59 2401073-8 1990 Treatment with recombinant human superoxide dismutase (hSOD, 5 mg/kg/hr, that is, 15,545 SOD units/kg/hr), starting 10 minutes before reperfusion, preserved the vasodilator response to ACh (82 +/- 6%) and A23187, but treatment with the hydroxyl ion scavenger N-(2-mercapto proprionyl)-glycine (MPG) (8 mg/kg/hr) only protected the A23187 response. Hydroxyl Radical 236-244 superoxide dismutase 1 Homo sapiens 56-59 2134197-1 1990 Radical adducts of 5,5-dimethyl-1-pyrroline N-oxide (DMPO) with hydroxyl, methanol-derived, and ethanol-derived radicals were detected by a combination of liquid chromatography with either electron paramagnetic resonance or thermospray mass spectrometry (LC/EPR or LC/TSP-MS) in the Fenton system (with methanol or ethanol). Hydroxyl Radical 64-72 thrombospondin 1 Homo sapiens 268-271 2262946-4 1990 Superoxide dismutase (SOD) and catalase (CAT) are intracellular enzymes that scavenge the superoxide and hydroxyl radicals respectively. Hydroxyl Radical 105-122 catalase Rattus norvegicus 31-39 2262946-4 1990 Superoxide dismutase (SOD) and catalase (CAT) are intracellular enzymes that scavenge the superoxide and hydroxyl radicals respectively. Hydroxyl Radical 105-122 catalase Rattus norvegicus 41-44 2171513-10 1990 Our results support the ability of myeloperoxidase derived HOCl to act as a direct oxidative activator of HNC and further suggest the existence of a new/alternative oxidative activation pathway of HNC involving hydroxyl radical. Hydroxyl Radical 211-227 myeloperoxidase Homo sapiens 35-50 2162840-7 1990 By contrast, methylation interference and hydroxyl radical footprinting demonstrate that the T3 binding element of TRE2 is not structurally similar to TRE1 except for a purine-rich octameric cluster (underlined, 5"-ATCAAAGGAGGAGGAGCCA-3") containing six guanines on the sense strand. Hydroxyl Radical 42-58 ubiquitin specific peptidase 6 Homo sapiens 115-119 2214759-4 1990 Mono-hydroxylation of the highly hydrophobic non-substituted TPE skeleton led to a large increase in relative binding affinity for ER which could be explained by a dual mechanism whereby the interaction specific to the hydroxyl is accompanied by a temperature- or time-dependent binding process that is not related to the hydroxylation position. Hydroxyl Radical 5-13 estrogen receptor 1 Bos taurus 131-133 2226525-5 1990 Analysis of other similar regions in apoB-100 and other glycosaminoglycan-binding proteins suggest that besides a cluster of positively charged amino-acids, the presence of hydroxyl-containing residues favours the association with sulphated proteoglycans. Hydroxyl Radical 173-181 apolipoprotein B Homo sapiens 37-45 2372377-1 1990 A combination of the gel retardation assay and interference by hydroxyl radical modification (missing nucleoside technique) was used to analyze the interaction of the glucocorticoid receptor (GR) with various glucocorticoid responsive elements (GRE). Hydroxyl Radical 63-79 nuclear receptor subfamily 3 group C member 1 Homo sapiens 192-194 2380097-6 1990 Possible mechanisms of interaction of TNF and X rays including induction of hydroxyl radicals and subsequent DNA damage by TNF and radiation are discussed. Hydroxyl Radical 76-93 tumor necrosis factor Homo sapiens 38-41 2370303-2 1990 As determined by charcoal adsorption from 2% serum in which binding to T4-binding globulin and transthyretin had been inhibited, increased T4 binding by Alb-FDH was pH dependent and proportional to the ionization of the phenolic hydroxyl. Hydroxyl Radical 229-237 albumin Homo sapiens 153-156 2308398-4 1990 We tested the effect of hydrogen peroxide, cumene hydroperoxide, t-butyl hydroperoxide and hydroxyl and superoxide radicals on GPX, SOD and catalase. Hydroxyl Radical 91-99 superoxide dismutase 1 Homo sapiens 132-135 1964798-2 1990 Though mechanisms of the cytotoxicity and selectivity of TNF action in vitro are not clear, there is much evidence that free radicals such as superoxide and hydroxyl radicals, mediated by TNF, are correlated with TNF cytotoxicity. Hydroxyl Radical 157-174 tumor necrosis factor Homo sapiens 57-60 1964798-2 1990 Though mechanisms of the cytotoxicity and selectivity of TNF action in vitro are not clear, there is much evidence that free radicals such as superoxide and hydroxyl radicals, mediated by TNF, are correlated with TNF cytotoxicity. Hydroxyl Radical 157-174 tumor necrosis factor Homo sapiens 188-191 1964798-2 1990 Though mechanisms of the cytotoxicity and selectivity of TNF action in vitro are not clear, there is much evidence that free radicals such as superoxide and hydroxyl radicals, mediated by TNF, are correlated with TNF cytotoxicity. Hydroxyl Radical 157-174 tumor necrosis factor Homo sapiens 188-191 2158821-8 1990 Hydroxyl radical-induced aggregates of glyceraldehyde-3-phosphate dehydrogenase were also degraded very rapidly by this enzyme, but hydroxyl radical-induced aggregates of alcohol dehydrogenase were resistent to enzymatic degradation. Hydroxyl Radical 0-16 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 39-79 2158821-8 1990 Hydroxyl radical-induced aggregates of glyceraldehyde-3-phosphate dehydrogenase were also degraded very rapidly by this enzyme, but hydroxyl radical-induced aggregates of alcohol dehydrogenase were resistent to enzymatic degradation. Hydroxyl Radical 0-16 aldo-keto reductase family 1 member A1 Homo sapiens 171-192 2158821-8 1990 Hydroxyl radical-induced aggregates of glyceraldehyde-3-phosphate dehydrogenase were also degraded very rapidly by this enzyme, but hydroxyl radical-induced aggregates of alcohol dehydrogenase were resistent to enzymatic degradation. Hydroxyl Radical 132-148 aldo-keto reductase family 1 member A1 Homo sapiens 171-192 2154454-1 1990 Failure to detect hydroxyl radical (.OH)-derived spin adducts of 5,5-dimethyl-1-pyrroline N-oxide in electron spin resonance (ESR) spin trapping experiments has been offered as evidence for the lack of the endogenous capacity of stimulated human phagocytes (neutrophils, monocytes, and monocyte-derived macrophages (MDM] to generate .OH. Hydroxyl Radical 18-34 spindlin 1 Homo sapiens 49-53 2187994-1 1990 A series of low-nanomolar renin inhibitors containing novel C-terminal heterocycles has been designed by formally cyclizing the C-terminus of a glycol-based inhibitor to the second hydroxyl. Hydroxyl Radical 181-189 renin Homo sapiens 26-31 2161619-2 1990 Experiments were conducted to evaluate whether NADH generated from a reconstituted system containing ethanol plus NAD+ plus ADH could interact with ferric chelates to promote microsomal lipid peroxidation and generation of a hydroxyl radical (OH)-like species. Hydroxyl Radical 225-241 aldo-keto reductase family 1 member A1 Homo sapiens 48-51 2308398-4 1990 We tested the effect of hydrogen peroxide, cumene hydroperoxide, t-butyl hydroperoxide and hydroxyl and superoxide radicals on GPX, SOD and catalase. Hydroxyl Radical 91-99 catalase Homo sapiens 140-148 2308398-7 1990 Catalase was inactivated by hydroxyl radicals and by superoxide anions but organic peroxides had no effect. Hydroxyl Radical 28-45 catalase Homo sapiens 0-8 2176782-3 1990 In the presence of dihydralazine the radical production increases distinctly; the higher hydroxyl radical production is observed for the dihydralazine-SOD containing system which is explained by the partial decomposition of the enzyme in the presence of dihydralazine. Hydroxyl Radical 89-105 superoxide dismutase 1 Homo sapiens 151-154 2107864-9 1990 The findings are consistent with the hypothesis that nitrous oxide combines with the vitamin B12 molecule of methionine synthase to form a hydroxyl radical that reacts with an inactivates the enzyme, and that DMTU slows this inactivation by scavenging hydroxyl radicals. Hydroxyl Radical 139-155 5-methyltetrahydrofolate-homocysteine methyltransferase Mus musculus 109-128 2107864-9 1990 The findings are consistent with the hypothesis that nitrous oxide combines with the vitamin B12 molecule of methionine synthase to form a hydroxyl radical that reacts with an inactivates the enzyme, and that DMTU slows this inactivation by scavenging hydroxyl radicals. Hydroxyl Radical 252-269 5-methyltetrahydrofolate-homocysteine methyltransferase Mus musculus 109-128 2107864-0 1990 Dimethylthiourea, a hydroxyl radical scavenger, impedes the inactivation of methionine synthase by nitrous oxide in mice. Hydroxyl Radical 20-36 5-methyltetrahydrofolate-homocysteine methyltransferase Mus musculus 76-95 2160054-0 1990 RecA-ssDNA interaction: induced strand cleavage by hydroxyl radical at a defined distance from the 5" end. Hydroxyl Radical 51-67 RAD51 recombinase Homo sapiens 0-4 2160054-1 1990 Interaction of the RecA protein with single-stranded DNA (ssDNA) was analyzed by challenge with the hydroxyl radical, which can cleave the DNA backbone. Hydroxyl Radical 100-116 RAD51 recombinase Homo sapiens 19-23 2153108-0 1990 Kinetic studies on spin trapping of superoxide and hydroxyl radicals generated in NADPH-cytochrome P-450 reductase-paraquat systems. Hydroxyl Radical 51-68 cytochrome p450 oxidoreductase Homo sapiens 82-114 1963617-3 1990 A decrease in the bleaching rates was observed upon addition of SOD or hydroxyl radical scavengers, showing that the hydrogen peroxide/Ni(II)/glycyl-glycyl-L-histidine system generated superoxide anions as well as hydroxyl radicals. Hydroxyl Radical 214-231 superoxide dismutase 1 Homo sapiens 64-67 2105855-6 1990 Superoxide dismutase exerted two distinct effects on the autoxidation of naphthohydroquinones formed during DT-diaphorase catalysis: on the one hand, it enhanced slightly the autoxidation of 1,4-naphthohydroquinones with a hydroxyl substituent in the benzene ring: 5-hydroxy-1,4-naphthoquinone and the corresponding derivatives with methyl- and/or glutathionyl substituents at C2 and C3, respectively. Hydroxyl Radical 223-231 NAD(P)H quinone dehydrogenase 1 Homo sapiens 108-121 2074049-1 1990 CuPu(Py)2 and CuPu(Im)2, two novel dischiffbase coordinated low Mr active centre analogues of Cu2Zn2 superoxide dismutase, were shown to effectively catalyze the production of hydroxyl radicals in the presence and absence of TPA-activated polymorphonuclear leukocytes. Hydroxyl Radical 176-193 plasminogen activator, tissue type Rattus norvegicus 225-228 2167264-5 1990 The hydroxyl radical generation potential of the fresh quartz particles decreases on storing in ambient air and on the addition of catalase, superoxide dismutase, desferroxamine, or DMSO. Hydroxyl Radical 4-20 catalase Homo sapiens 131-139 2292433-2 1990 Hydroxyl radicals abstract hydrogen atoms from glycerol-2-phosphate with a specific rate constant of (7.0 +/- 1.5) x 10(8) M-1s-1 forming the beta-phospho radical as the major product. Hydroxyl Radical 0-17 tumor associated calcium signal transducer 2 Homo sapiens 123-129 33811464-4 2021 For this purpose, MCT4-inhibiting siRNAs are incorporated into reactivity-switchable PBNM-based nanocatalysts to initiate hydroxyl radical production. Hydroxyl Radical 122-138 solute carrier family 16 (monocarboxylic acid transporters), member 3 Mus musculus 18-22 2167271-0 1990 Spin trapping of ibuprofen radicals: evidence that ibuprofen is a hydroxyl radical scavenger. Hydroxyl Radical 66-82 spindlin 1 Homo sapiens 0-4 9146888-13 1997 It was found that photolysis of rose bengal from a 1:2:2:1 quartet, characteristic of the hydroxyl radical-DMPO spin adduct, which was effectively blunted by DMTU, superoxide dismutase and catalase whereas histidine was ineffective. Hydroxyl Radical 90-106 catalase Oryctolagus cuniculus 189-197 33815647-3 2020 Results obtained by flowing hydrocarbons (CH4 and CH3CHCH2) unequivocally show that these gases react with surface hydroxyl groups to produce water without producing carbon oxides and release electrons that localize on Sn to eventually form SnO. Hydroxyl Radical 115-123 strawberry notch homolog 1 Homo sapiens 241-244 16337888-5 2006 These results demonstrate that vanadium in the +2, +3, and +4 valence states interacts prooxidatively with human neutrophils, competing effectively with MPO for hydrogen peroxide to promote formation of the highly toxic hydroxyl radical. Hydroxyl Radical 220-236 myeloperoxidase Homo sapiens 153-156 8070342-5 1994 Both TA3 and TA4 glucuronides were stable during treatment with dilute base or methanol, suggesting that they represent ether glucuronides with the phenolic hydroxyl group. Hydroxyl Radical 157-165 trace amine associated receptor 9 Homo sapiens 5-8 8070342-5 1994 Both TA3 and TA4 glucuronides were stable during treatment with dilute base or methanol, suggesting that they represent ether glucuronides with the phenolic hydroxyl group. Hydroxyl Radical 157-165 trace amine associated receptor 6 Homo sapiens 13-16 34973200-2 2022 This ALP-p was synthesized with 98.5% yield, from pararosaniline and phloroglucinol, via the diazo coupling reaction to produce multiple adsorption functional groups of benzene ring, hydroxyl group and azo group. Hydroxyl Radical 183-191 alkaline phosphatase, placental Homo sapiens 5-10 34742912-0 2022 Hydroxyl radical footprinting analysis of a human haptoglobin-hemoglobin complex. Hydroxyl Radical 0-16 haptoglobin Homo sapiens 50-61 34965011-3 2022 Under the acidic environments of lysosomes, Ir1 can effectively catalyze Fenton reaction, produce hydroxyl radicals, induce lipid peroxidation, down-regulate glutathione peroxidase 4, and induce ferroptosis. Hydroxyl Radical 98-115 nischarin Homo sapiens 44-47 34388924-0 2022 Synergy of surface sodium and hydroxyl on NaTi2HO5 nanotubes accelerating the Pt-dominated ambient HCHO oxidation. Hydroxyl Radical 30-38 N-acetyltransferase 1 Homo sapiens 42-46 34500153-4 2022 Then, the dissociation of CMC-DD2 was efficiently triggered by intracellular hydrogen peroxide (H2O2) with the release of DNA damaging agents, including nitrate anions, hydroxyl radicals ( OH) and DD2. Hydroxyl Radical 169-186 aldo-keto reductase family 1 member C2 Homo sapiens 30-33 34883515-5 2021 Here, we present a model of 40S-bound DHX29, supported by directed hydroxyl radical cleavage data, showing that the intersubunit domain comprises a dsRNA-binding domain (dsRBD, aa 377-448) whereas linker corresponds to the long alpha-helix (aa 460-512) that follows the dsRBD. Hydroxyl Radical 67-83 DExH-box helicase 29 Homo sapiens 38-43 34957819-4 2021 After effective accumulation at the tumor site due to the enhanced permeability and retention (EPR) effect and specific recognition of hyaluronate acid with CD44 protein on the surface of tumor cells, plenty of Ca2+, Cu2+, and H2O2 can be simultaneously released in acid and hyaluronidase overexpressed tumor microenvironment (TME), generating abundant hydroxyl radical through enhanced Fenton-type reaction between Cu2+ and self-supplying H2O2 with the assistance of glutathione depletion. Hydroxyl Radical 353-369 CD44 molecule (Indian blood group) Homo sapiens 157-161 34829078-9 2021 In addition, the thiobarbituric acid reactive substances (TBARS) value and the content of hydroxyl radicals in the CAT group increased significantly. Hydroxyl Radical 90-107 catalase Homo sapiens 115-118 34385012-4 2021 A cascaded catalytic reaction is triggered by glucose, in which GOx catalyzes the oxidation of glucose into gluconic acid and hydrogen peroxide (H2O2), and hydroxyl radical ( OH) is further produced with the catalysis of GQDs nanozyme with peroxidase-like activity, resulting in the degradation of AgNPs@GQDs-GOx with the release of Ag+. Hydroxyl Radical 156-172 hydroxyacid oxidase 1 Homo sapiens 309-312 34571083-6 2021 Ectopic expression of SLC7A11 partly reversed miR-5096-mediated effects on cell survival, ROS, lipid peroxides, iron accumulation, GSH, hydroxyl radicals, mitochondrial membrane potential, and colony formation. Hydroxyl Radical 136-153 solute carrier family 7 member 11 Homo sapiens 22-29 34571083-6 2021 Ectopic expression of SLC7A11 partly reversed miR-5096-mediated effects on cell survival, ROS, lipid peroxides, iron accumulation, GSH, hydroxyl radicals, mitochondrial membrane potential, and colony formation. Hydroxyl Radical 136-153 microRNA 5096 Homo sapiens 46-54 34974860-7 2021 Upon arriving at the tumor tissue, the Gox catalyzed the glucose of tumor to create H2O2, which further served as the substrate of UPBNPs, a peroxidase mimic, to finally give highly toxic hydroxyl radical (OH) for cancer therapy. Hydroxyl Radical 188-204 hydroxyacid oxidase 1 Homo sapiens 39-42 34302797-5 2021 In the former, the selectivity of sphingolipid synthesis relies on a hydrogen bond interaction between Lys379 of SPTLC2 and the l-serine sidechain hydroxyl moiety. Hydroxyl Radical 147-155 serine palmitoyltransferase long chain base subunit 2 Homo sapiens 113-119 34702470-4 2021 Phenolic hydroxyl groups were introduced into CNCs, resulting in good antioxidant activity with an IC50 value of 1.49 mg/mL, although a slight decrease in the crystallinity index and thermal properties was observed. Hydroxyl Radical 9-17 thrombopoietin Mus musculus 121-123 34668000-5 2021 Additionally, the Zn0.2Fe2.8O4@PDA@MnO2 NPs can significantly consume overexpressed glutathione (GSH) and generate Mn2+ in the tumor microenvironment (TME), thus destroying redox homeostasis and catalytically generating hydroxyl radicals ( OH) for HSP suppression and PTT enhancement. Hydroxyl Radical 220-237 heat shock protein 90 beta family member 2, pseudogene Homo sapiens 248-251 34175540-2 2021 These complexes were heavily taken up by cells and reacted with cellular glutathione (GSH) to reduce Cu2+ to Fenton-like Cu+, which catalyzed endogenous H2O2 to produce the highly toxic hydroxyl radicals ( OH) to kill cancer cells. Hydroxyl Radical 186-203 immunoglobulin kappa variable 1-35 Mus musculus 101-104 34641764-5 2021 MCS displayed an excellent adsorption capacity in which chemical adsorption was the main effect, and hydroxyl radicals were the major contributor to BPA degradation. Hydroxyl Radical 101-118 Miles-Carpenter X-linked mental retardation syndrome Homo sapiens 0-3 34251993-7 2021 In this report, we show that siz1 overaccumulates Fe in its root apoplasts, and consequently, produces more hydroxyl radicals, which are detrimental to root growth. Hydroxyl Radical 108-125 DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein Arabidopsis thaliana 29-33 34590840-3 2021 Upon US irradiation, AIBA@FeCuS-FeCO could be degraded and release cytotoxic AIBA radicals, CO, Fe2+, and Cu2+, allowing us to (1) enhance tumor uptake of AIBA@FeCuS-FeCO through CO-mediated vasodilation, (2) promote hydroxyl radical production and induce tumor ferroptosis via intracellular accumulation of Fe2+/Cu2+, and (3) kill tumor cells. Hydroxyl Radical 217-233 immunoglobulin kappa variable 1-35 Mus musculus 106-109 34755670-2 2021 METHODS: Three polysaccharides with different molecular masses, namely RPS-1, RPS-2 and RPS-3, were separated from the fermentation broth of Rhizopus nigricans by fractional ethanol precipitation, and their capacity for scavenging DPPH, ABTS, and hydroxyl radicals was assessed. Hydroxyl Radical 247-264 ribosomal protein S3 Mus musculus 88-93 34755670-4 2021 RESULTS: All the 3 polysaccharides had good antioxidant activities, and among them RPS-1 with a medium molecular mass exhibited the strongest scavenging capacity for DPPH and ABTS radicals (P < 0.05) while RPS-3 with the lowest molecular mass had the best scavenging activity for hydroxyl radicals (P < 0.01). Hydroxyl Radical 280-297 ribosomal protein S3 Mus musculus 206-211 34721070-3 2021 It has been suggested that hydrogen gas, as an antioxidant, can selectively scavenge hydroxyl radicals but does not affect superoxide anion"s signal transduction. Hydroxyl Radical 85-102 gastrin Rattus norvegicus 36-39 34251993-9 2021 Based on previously published work and the results of the current study, we propose that SIZ1 regulates Pi deficiency-mediated PR growth through modulating the accumulation of Fe and the production of hydroxyl radicals by controlling ALMT1 expression. Hydroxyl Radical 201-218 DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein Arabidopsis thaliana 89-93 34251993-9 2021 Based on previously published work and the results of the current study, we propose that SIZ1 regulates Pi deficiency-mediated PR growth through modulating the accumulation of Fe and the production of hydroxyl radicals by controlling ALMT1 expression. Hydroxyl Radical 201-218 aluminum-activated malate transporter 1 Arabidopsis thaliana 234-239 34330026-4 2021 The mechanism of SPC activation by CuFeS2 was elucidated, which was discovered to be a multiple reactive oxygen species (multi-ROS) process with the coexistence of hydroxyl radical ( OH), carbonate radical (CO3 -), superoxide radical (O2 -), and singlet oxygen (1O2), as evidenced by quenching experiments and electron spin resonance (ESR) tests. Hydroxyl Radical 164-180 surfactant protein C Homo sapiens 17-20 34560395-13 2021 Relevant intensification in hydroxyl radicals production is observed by the UV-US system increasing up three folds the ACE removal and mineralization and two folds higher biodegradability of effluent in particular for 376R and 376H cases at optimal operation condition of dual-frequency signal. Hydroxyl Radical 28-45 angiotensin I converting enzyme Homo sapiens 119-122 34363947-4 2021 Cytokine (a mixture of IL-1beta, TNF-alpha, and IFN-gamma) treated AQP8 KD cells exhibited pronounced sensitivity to reactive oxygen and nitrogen species (ROS and RNS), resulting in a significant loss of beta-cell viability due to enhanced toxicity of the increased concentrations of H2O2 and hydroxyl radicals ( OH) in mitochondria of AQP8 KD cells. Hydroxyl Radical 293-310 interleukin 1 alpha Rattus norvegicus 23-31 34363947-4 2021 Cytokine (a mixture of IL-1beta, TNF-alpha, and IFN-gamma) treated AQP8 KD cells exhibited pronounced sensitivity to reactive oxygen and nitrogen species (ROS and RNS), resulting in a significant loss of beta-cell viability due to enhanced toxicity of the increased concentrations of H2O2 and hydroxyl radicals ( OH) in mitochondria of AQP8 KD cells. Hydroxyl Radical 293-310 tumor necrosis factor Rattus norvegicus 33-42 34363947-4 2021 Cytokine (a mixture of IL-1beta, TNF-alpha, and IFN-gamma) treated AQP8 KD cells exhibited pronounced sensitivity to reactive oxygen and nitrogen species (ROS and RNS), resulting in a significant loss of beta-cell viability due to enhanced toxicity of the increased concentrations of H2O2 and hydroxyl radicals ( OH) in mitochondria of AQP8 KD cells. Hydroxyl Radical 293-310 interferon gamma Rattus norvegicus 48-57 34363947-4 2021 Cytokine (a mixture of IL-1beta, TNF-alpha, and IFN-gamma) treated AQP8 KD cells exhibited pronounced sensitivity to reactive oxygen and nitrogen species (ROS and RNS), resulting in a significant loss of beta-cell viability due to enhanced toxicity of the increased concentrations of H2O2 and hydroxyl radicals ( OH) in mitochondria of AQP8 KD cells. Hydroxyl Radical 293-310 aquaporin 8 Rattus norvegicus 67-71 34363947-4 2021 Cytokine (a mixture of IL-1beta, TNF-alpha, and IFN-gamma) treated AQP8 KD cells exhibited pronounced sensitivity to reactive oxygen and nitrogen species (ROS and RNS), resulting in a significant loss of beta-cell viability due to enhanced toxicity of the increased concentrations of H2O2 and hydroxyl radicals ( OH) in mitochondria of AQP8 KD cells. Hydroxyl Radical 293-310 aquaporin 8 Rattus norvegicus 336-340 34454188-6 2021 The addition of Tert-butanol (TBA) reduced the FA removal by 59.4%, indicating that the hydroxyl radicals (OH) was the main active species. Hydroxyl Radical 88-105 telomerase reverse transcriptase Homo sapiens 16-20 34310960-6 2021 Then H2O2 not only damaged structure of Tf to release Fe3+, but also was converted to hydroxyl radicals via ferric ions mediated Fenton reaction for ferroptosis. Hydroxyl Radical 86-103 transferrin Homo sapiens 40-42 34475406-3 2021 Based on the O2 redistribution and H2O2 activation by cascading LOx and CAT catalytic metabolic regulation, hydroxyl radical ( OH) and singlet oxygen (1O2) production can be modulated for glutathione (GSH)-activated chemodynamic therapy (CDT) and NIR-triggered photodynamic therapy (PDT), by manipulating the ratio of LOx and CAT to catalyze endogenous lactate to produce H2O2 and further cascade decomposing H2O2 into O2. Hydroxyl Radical 108-124 lysyl oxidase Homo sapiens 64-67 34475406-3 2021 Based on the O2 redistribution and H2O2 activation by cascading LOx and CAT catalytic metabolic regulation, hydroxyl radical ( OH) and singlet oxygen (1O2) production can be modulated for glutathione (GSH)-activated chemodynamic therapy (CDT) and NIR-triggered photodynamic therapy (PDT), by manipulating the ratio of LOx and CAT to catalyze endogenous lactate to produce H2O2 and further cascade decomposing H2O2 into O2. Hydroxyl Radical 108-124 catalase Homo sapiens 72-75 34475406-3 2021 Based on the O2 redistribution and H2O2 activation by cascading LOx and CAT catalytic metabolic regulation, hydroxyl radical ( OH) and singlet oxygen (1O2) production can be modulated for glutathione (GSH)-activated chemodynamic therapy (CDT) and NIR-triggered photodynamic therapy (PDT), by manipulating the ratio of LOx and CAT to catalyze endogenous lactate to produce H2O2 and further cascade decomposing H2O2 into O2. Hydroxyl Radical 108-124 lysyl oxidase Homo sapiens 318-321 34475406-3 2021 Based on the O2 redistribution and H2O2 activation by cascading LOx and CAT catalytic metabolic regulation, hydroxyl radical ( OH) and singlet oxygen (1O2) production can be modulated for glutathione (GSH)-activated chemodynamic therapy (CDT) and NIR-triggered photodynamic therapy (PDT), by manipulating the ratio of LOx and CAT to catalyze endogenous lactate to produce H2O2 and further cascade decomposing H2O2 into O2. Hydroxyl Radical 108-124 catalase Homo sapiens 326-329 34134416-6 2021 On the basis of calculated structural/interfacial properties and experimental findings, the 2D Mg(OH)2 in terms of three-layer model was unraveled to substitute toxic Cd2+ ion and sorb radioactive UO22+ that is coordinated by water and hydroxyl groups. Hydroxyl Radical 236-244 CD2 molecule Homo sapiens 167-170 34298093-4 2021 Iron deficiency exacerbated cisplatin-induced iAKI by markedly increasing non-heme catalytic iron and Nox4 protein which together catalyze production of hydroxyl radicals followed by protein and DNA oxidation, apoptosis and ferroptosis. Hydroxyl Radical 153-170 NADPH oxidase 4 Homo sapiens 102-106 34363310-3 2021 The released Mn2+ can catalyze endogenous H2 O2 to hydroxyl radicals, while internal gold nanoparticles mimetic glucose oxidase (GOx) converted glucose into H2 O2 to accelerate the generation of hydroxyl radicals. Hydroxyl Radical 195-212 hydroxyacid oxidase 1 Homo sapiens 112-127 34363310-3 2021 The released Mn2+ can catalyze endogenous H2 O2 to hydroxyl radicals, while internal gold nanoparticles mimetic glucose oxidase (GOx) converted glucose into H2 O2 to accelerate the generation of hydroxyl radicals. Hydroxyl Radical 195-212 hydroxyacid oxidase 1 Homo sapiens 129-132 34165306-2 2021 Based upon the ATR-FTIR investigations combining with the mass spectroscopy (MS) analysis, a direct hydroxyl radical formation mechanism that is different from those observed for other semiconductor photocatalysts is proposed. Hydroxyl Radical 100-116 ATR serine/threonine kinase Homo sapiens 15-18 34145986-4 2021 It is then possible to conduct successful PDT treatment of this hypoxic tumor via laser irradiation, as the TBP-2 is able to generate hydroxyl radicals ( OH) via a type I mechanism within this hypoxic microenvironment. Hydroxyl Radical 134-151 TATA-box binding protein like 2 Homo sapiens 108-113 34270204-4 2021 The dynamically cross-linked chitosan (CS) and the flexible polyacrylamide network doped with polyaniline constitute the DN through the hydrogen bonds between the hydroxyl, amide, and aniline groups. Hydroxyl Radical 163-171 citrate synthase Homo sapiens 39-41 34356378-4 2021 Moreover, GLP-1 exhibited stronger antioxidant activities than GLP-2 in five different assays: 2,2"-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), hydroxyl radical, superoxide anion radical, ferric reducing antioxidant power (FRAP), and oxygen radical antioxidant capacity (ORAC). Hydroxyl Radical 157-173 glucagon Mus musculus 10-15 34611370-7 2021 Radical scavenger experiments indicated that hydroxyl radicals (HO ) are prevailing active species responsible for SMP removal in UV/Co(II)/PMS system. Hydroxyl Radical 45-62 mitochondrially encoded cytochrome c oxidase II Homo sapiens 133-139 34111923-3 2021 The kinetic analysis of the reaction mechanisms of trifluoroethene (CF2 CHF) with hydroxyl radicals is studied using computational chemistry at the M06-2X level with the 6-311++G(2d,d,p) and aug-cc-pVDZ basis sets as well as the composite CBS-QB3 method. Hydroxyl Radical 82-99 ATPase H+ transporting accessory protein 1 Homo sapiens 68-71 34208421-7 2021 Our study reveals the importance of axial-hydroxyl/phosphate for IP6K1 substrate recognition. Hydroxyl Radical 42-50 inositol hexaphosphate kinase 1 Mus musculus 65-70 34130454-4 2021 The LPMO/GDH system can enhance Fe3+-reducing activity, H2O2 production, and hydroxyl radical generation, resulting in a fueled Fenton reaction. Hydroxyl Radical 77-93 hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Homo sapiens 9-12 34611370-7 2021 Radical scavenger experiments indicated that hydroxyl radicals (HO ) are prevailing active species responsible for SMP removal in UV/Co(II)/PMS system. Hydroxyl Radical 64-66 mitochondrially encoded cytochrome c oxidase II Homo sapiens 133-139 35577098-3 2022 A long-period, multi-level intercomparison of hydroxyl radical (OH) measurements between AIOFM-LIF and PKU-LIF (the Peking University laser-induced fluorescence system) was conducted in Chengdu, China. Hydroxyl Radical 46-62 LIF interleukin 6 family cytokine Homo sapiens 95-98 35606848-6 2022 Furthermore, MPG NPs have good chemodynamic activity, which can convert the endogenous hydrogen peroxide of tumor cells into highly toxic hydroxyl radical through Fenton-like reaction at acidic pH to play the role of chemodynamic therapy. Hydroxyl Radical 138-154 N-methylpurine DNA glycosylase Homo sapiens 13-16 35487006-3 2022 On the one hand, the peroxidase-like catalytic activity made CS@Fe/CDs catalyze H2O2 for producing hydroxyl radicals ( OH), resulting in efficient cleavage of extracellular DNA (eDNA). Hydroxyl Radical 99-116 AT695_RS02070 Staphylococcus aureus 21-31 35306063-6 2022 According to the model results, we found that Fe complexation impacts the hydroxyl radical formation rate: contrary to our expectations, Fe complexation by natural organic ligands led to an increase in hydroxyl radical production. Hydroxyl Radical 74-90 general transcription factor IIE subunit 1 Homo sapiens 46-48 35306063-6 2022 According to the model results, we found that Fe complexation impacts the hydroxyl radical formation rate: contrary to our expectations, Fe complexation by natural organic ligands led to an increase in hydroxyl radical production. Hydroxyl Radical 74-90 general transcription factor IIE subunit 1 Homo sapiens 137-139 35306063-6 2022 According to the model results, we found that Fe complexation impacts the hydroxyl radical formation rate: contrary to our expectations, Fe complexation by natural organic ligands led to an increase in hydroxyl radical production. Hydroxyl Radical 202-218 general transcription factor IIE subunit 1 Homo sapiens 46-48 35306063-6 2022 According to the model results, we found that Fe complexation impacts the hydroxyl radical formation rate: contrary to our expectations, Fe complexation by natural organic ligands led to an increase in hydroxyl radical production. Hydroxyl Radical 202-218 general transcription factor IIE subunit 1 Homo sapiens 137-139 35429690-3 2022 The reaction activity of hydroxyl radicals ( OH) relative to TPH (K) notably increased to 0.65 when the degree of developed inactivation of the SOM (beta) was 100% (DIS-100), which was 1.45, 2.03 and 2.83-fold than that of DIS-50, DIS-15 and control (CK), respectively. Hydroxyl Radical 25-42 cytidine/uridine monophosphate kinase 1 Homo sapiens 251-253 35533403-7 2022 For TCBQ, the chlorine atoms cause the olefinic carbons to carry more positive atomic charges, and then, HO2- preferred to add to the olefinic carbons, which might induce the formation of the hydroxyl radical ( OH). Hydroxyl Radical 192-208 heme oxygenase 2 Homo sapiens 105-108 35576012-5 2022 When PLP is dephosphorized by ALP, the released free hydroxyl group reacts with aldehyde group to form internal hemiacetal, which leads to the failure of Schiff base formation. Hydroxyl Radical 53-61 alkaline phosphatase, placental Homo sapiens 30-33 35149425-5 2022 In acidic environment, hydroxyl radicals could be generated via the cascaded catalysis of beta-d-glucose by Fe3O4@Au-GOx, and then employed to initiate the polymerization of boric acid derivative to prepare molecularly imprinted polymers (MIPs) on the surface of GOx using beta-d-glucose as template. Hydroxyl Radical 23-40 hydroxyacid oxidase 1 Homo sapiens 117-120 35149425-5 2022 In acidic environment, hydroxyl radicals could be generated via the cascaded catalysis of beta-d-glucose by Fe3O4@Au-GOx, and then employed to initiate the polymerization of boric acid derivative to prepare molecularly imprinted polymers (MIPs) on the surface of GOx using beta-d-glucose as template. Hydroxyl Radical 23-40 hydroxyacid oxidase 1 Homo sapiens 263-266 35471651-3 2022 In the present study, the aqueous phase reaction kinetics of hydroxyl radicals ( OH) with the four amino acids is investigated using the competition kinetics method under controlled temperature and pH conditions. Hydroxyl Radical 61-78 phenylalanine hydroxylase Homo sapiens 198-200 35502893-8 2022 The resulting binuclear complex undergoes intramolecular electron transfer to give Fe(II), which later generates HO from H2O2, plus MnO2+, which later decomposes to HO2 /O2 - (an Fe(III) reductant) and Mn(II), completing the catalytic cycle. Hydroxyl Radical 113-115 heme oxygenase 2 Homo sapiens 166-169 35080370-5 2022 CFp NPs degrade under the mildly acidic conditions of TME, self-supply H2O2, and the released Cu and Fe ions, with their larger portions at lower oxidation states, cooperatively facilitate hydroxyl radical production through a highly efficient catalytic loop to achieve an excellent tumor therapeutic efficacy. Hydroxyl Radical 189-205 complement factor properdin Homo sapiens 0-3 35404578-0 2022 Singlet Oxygen and Mobile Hydroxyl Radicals Co-operating on Gas-Solid Catalytic Reaction Interfaces for Deeply Oxidizing NOx. Hydroxyl Radical 26-43 gastrin Homo sapiens 60-63 35404578-2 2022 Besides the great contribution of the conventional O2- reactive species, a synergic effect between a singlet oxygen (1O2) and mobile hydroxyl radicals ( OHf) was first illustrated for removing NOx indoor gas (1O2 + 2NO 2NO2, NO2 + OHf HNO3), inhibiting the production of the byproducts of NO2. Hydroxyl Radical 134-151 gastrin Homo sapiens 205-208 35032519-4 2022 Meanwhile, the sp2-hybridized pi conjugation bond of amorphous carbon can rapidly capture and store photogenerated electrons, inhibiting charge carrier recombination and thus generating more electrons to facilitate the yield of hydroxyl radicals. Hydroxyl Radical 228-245 Sp2 transcription factor Homo sapiens 15-18 35531284-6 2022 Of which, EP3, EP4, EP5, and EP6 showed strong scavenging activities on DPPH , hydroxyl radical (HO ), and superoxide anion radical (O- 2 ). Hydroxyl Radical 97-99 prostaglandin E receptor 4 Homo sapiens 15-18 35408700-0 2022 Kinetics of the Gas-Phase Reaction of Hydroxyl Radicals with Dimethyl Methylphosphonate (DMMP) over an Extended Temperature Range (273-837 K). Hydroxyl Radical 38-55 PAXIP1 associated glutamate rich protein 1 Homo sapiens 16-19 35408700-1 2022 The kinetics of the reaction of hydroxyl radical (OH) with dimethyl methylphosphonate (DMMP, (CH3O)2CH3PO) (reaction 1) OH + DMMP products (1) was studied at the bath gas (He) pressure of 1 bar over the 295-837 K temperature range. Hydroxyl Radical 32-48 PAXIP1 associated glutamate rich protein 1 Homo sapiens 169-172 35269859-5 2022 T1AM and TA1 showed in-vitro antioxidant and superoxide scavenging properties, while only TA1 acted as a hydroxyl radical scavenger. Hydroxyl Radical 105-121 trace amine associated receptor 1 Homo sapiens 90-93 35269859-8 2022 Our results suggest that SIRT1 is the mediator of T1AM and TA1 pro-or anti-oxidant effects as a result of ROS intracellular levels, including the hydroxyl radical. Hydroxyl Radical 146-162 sirtuin 1 Homo sapiens 25-30 35269859-8 2022 Our results suggest that SIRT1 is the mediator of T1AM and TA1 pro-or anti-oxidant effects as a result of ROS intracellular levels, including the hydroxyl radical. Hydroxyl Radical 146-162 trace amine associated receptor 1 Homo sapiens 59-62 35426140-0 2022 Effect of phenolic compounds and hydroxyl content on the physicochemical properties of pine nut oil Pickering emulsions. Hydroxyl Radical 33-41 NUT midline carcinoma family member 1 Homo sapiens 92-95 35401827-7 2022 Hydroxyl radical ( OH) and species derived from its interactions with other species were found to be the most effective CAP components for triggering ACE2 nucleus translocation. Hydroxyl Radical 0-16 angiotensin converting enzyme 2 Homo sapiens 150-154 35044388-5 2022 In detail, benefiting from the internal synergistic effect of Fe3O4 NPs and Au NPs and external NIR-mediated hyperthermia, the BFA NPs can boost hydroxyl radical ( OH) generation to enhance intracellular oxidative stress and further induce ferroptosis by inactivating glutathione peroxidase 4 (GPX4). Hydroxyl Radical 145-161 glutathione peroxidase 4 Homo sapiens 268-292 35044388-5 2022 In detail, benefiting from the internal synergistic effect of Fe3O4 NPs and Au NPs and external NIR-mediated hyperthermia, the BFA NPs can boost hydroxyl radical ( OH) generation to enhance intracellular oxidative stress and further induce ferroptosis by inactivating glutathione peroxidase 4 (GPX4). Hydroxyl Radical 145-161 glutathione peroxidase 4 Homo sapiens 294-298 2626489-6 1989 Inhibition of catalase may render skin more susceptible to the damaging effects of hydrogen peroxide and its reaction products such as the hydroxyl radical. Hydroxyl Radical 139-155 catalase Mus musculus 14-22 35065503-3 2022 Strain GR-3 removed 50.67% of 50 mg/L As(III) and exhibited the high antioxidant potential of DPPH (1,1-Diphenyl-2-picrylhydrazyl) (87.63%) and hydroxyl radical (74.51%) scavenging rate in vitro. Hydroxyl Radical 144-160 semaphorin 4D Homo sapiens 7-11 35174317-4 2022 MYCN increases iron metabolism and subsequent hydroxyl radicals through increased expression of the transferrin receptor 1 (TfR1) and low levels of the ferroportin receptor. Hydroxyl Radical 46-63 MYCN proto-oncogene, bHLH transcription factor Homo sapiens 0-4 34983560-5 2022 Specifically, the GOx/POD cascade reaction generating consecutive fluxes of toxic hydroxyl radical spatially targets the acidic biofilm (pH ~ 5.5), and eradicates biofilm to shorten the inflammatory phase and initiate normal wound healing processes. Hydroxyl Radical 82-98 hydroxyacid oxidase 1, liver Mus musculus 18-21 35174317-4 2022 MYCN increases iron metabolism and subsequent hydroxyl radicals through increased expression of the transferrin receptor 1 (TfR1) and low levels of the ferroportin receptor. Hydroxyl Radical 46-63 transferrin receptor Homo sapiens 124-128 35174317-5 2022 To counter increased hydroxyl radicals, MYCN binds to the promoter of SLC3A2 (solute carrier family 3 member 2). Hydroxyl Radical 21-38 MYCN proto-oncogene, bHLH transcription factor Homo sapiens 40-44 35174317-5 2022 To counter increased hydroxyl radicals, MYCN binds to the promoter of SLC3A2 (solute carrier family 3 member 2). Hydroxyl Radical 21-38 solute carrier family 3 member 2 Homo sapiens 70-76 2560462-7 1989 Inhibition by sodium azide and sodium benzoate indicated that these oxygen metabolites could be derived from the MPO-halide system but also from hydroxyl radical production. Hydroxyl Radical 145-161 myeloperoxidase Homo sapiens 113-116 2597702-1 1989 The binding of hydroxyl and keto bile salts to bovine serum albumin was studied by fluorescence and circular dichroism spectroscopies. Hydroxyl Radical 15-23 albumin Homo sapiens 54-67 2601332-1 1989 In order to develop high affinity, fluorescent ligands for the estrogen receptor based on 2-arylindenes, it is important to understand how this non-steroidal estrogen is oriented within the binding site and to know how hydroxyl substituents affect binding. Hydroxyl Radical 219-227 estrogen receptor 1 Homo sapiens 63-80 2511324-6 1989 GAL4 (1-147) makes rotationally symmetric contacts with its recognition site when assayed by DNase I, exonuclease III and hydroxyl radical footprinting and by phosphate ethylation interference. Hydroxyl Radical 122-138 galactose-responsive transcription factor GAL4 Saccharomyces cerevisiae S288C 0-4 2682525-2 1989 This increase in mutation frequency is abolished when the inhibitors desferrioxamine, superoxide dismutase, catalase or dimethyl sulfoxide are included in the initial reaction or when the iron/EDTA complex is omitted, a strong indication that the premutagenic damage arises as a result of direct attack by hydroxyl radical generated in a superoxide driven Fenton reaction. Hydroxyl Radical 306-322 catalase Homo sapiens 108-116 2552414-0 1989 Hydroxyl radical footprints reveal novel structural features around the NF I binding site in adenovirus DNA. Hydroxyl Radical 0-16 nuclear factor I C Homo sapiens 72-76 2552414-2 1989 NF I binding alters the accessibility of the deoxyribose moieties to hydroxyl radicals both at the 3" and at the 5" side of the recognition sequence 5"-TGG(N)6GCCAA-3". Hydroxyl Radical 69-86 nuclear factor I C Homo sapiens 0-4 2549063-10 1989 ESR studies using 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) showed that the hydroxyl radical adduct of DMPO was formed during the reaction of Cu(II) with H2O2, and that the addition of sodium formate produced the CO2- radical adduct of DMPO more efficiently than expected. Hydroxyl Radical 74-90 complement C2 Homo sapiens 211-214 2545706-5 1989 However, superoxide destroys the preformed hydroxyl radical spin-trapped adduct, 2,2-dimethyl-5-hydroxy-1-pyrrolidinyloxy (DMPO-OH), and DMPO-CH3. Hydroxyl Radical 43-59 spindlin 1 Homo sapiens 60-64 2476132-5 1989 The hydroxyl radical generation was inhibited by catalase and superoxide dismutase, suggesting a mechanism in which the phenols oxidize to produce superoxide radical, which then assists .OH generation from H2O2 in the presence of Fe3+-EDTA. Hydroxyl Radical 4-20 catalase Rattus norvegicus 49-57 2550002-0 1989 Chromium (V) and hydroxyl radical formation during the glutathione reductase-catalyzed reduction of chromium (VI). Hydroxyl Radical 17-33 glutathione-disulfide reductase Homo sapiens 55-76 2769689-5 1989 This orientation is supported by the fact that hydroxyl substitution at C-6 in the indene markedly elevates binding relative to hydroxyl substitution at the para position of the 2-phenyl substituent. Hydroxyl Radical 47-55 complement C6 Homo sapiens 72-75 2769689-5 1989 This orientation is supported by the fact that hydroxyl substitution at C-6 in the indene markedly elevates binding relative to hydroxyl substitution at the para position of the 2-phenyl substituent. Hydroxyl Radical 128-136 complement C6 Homo sapiens 72-75 2538353-0 1989 Inactivation of alpha 1-antiproteinase by hydroxyl radicals. Hydroxyl Radical 42-59 serpin family A member 1 Homo sapiens 16-38 2494147-10 1989 It is concluded that active oxygen species, in particular hydroxyl radicals, may be generated during thrombin stimulation of platelets and cause injury to the endothelial cells. Hydroxyl Radical 58-75 coagulation factor II, thrombin Homo sapiens 101-109 2548593-6 1989 Evidence for the production of hydroxyl radical during iron-catalyzed oxidation of VP-16 catechol was obtained. Hydroxyl Radical 31-47 host cell factor C1 Homo sapiens 83-88 2730676-10 1989 Analysis of these structure-activity data revealed a model of the minimal essential features required for PKC inhibition by flavonoids: a coplanar flavone structure with free hydroxyl substituents at the 3", 4" and 7-positions. Hydroxyl Radical 175-183 protein kinase C, gamma Rattus norvegicus 106-109 2538230-0 1989 Intracellular hydroxyl radical production induced by recombinant human tumor necrosis factor and its implication in the killing of tumor cells in vitro. Hydroxyl Radical 14-30 tumor necrosis factor Homo sapiens 71-92 2538230-1 1989 This study investigated the effect of recombinant human tumor necrosis factor (rhTNF) on hydroxyl radical production by established cell lines in vitro, and its implication in the killing of tumor cells by rhTNF. Hydroxyl Radical 89-105 tumor necrosis factor Homo sapiens 56-77 2538230-2 1989 During incubation of TNF sensitive mouse tumorigenic fibroblast L-M cells (2 X 10(7) cells) in the presence of rhTNF (100 U), hydroxyl radical production as detected by the evolution of methane gas from dimethyl sulfoxide increased gradually, at 18 h reaching 1.8 times that in the absence of rhTNF. Hydroxyl Radical 126-142 tumor necrosis factor Mus musculus 21-24 2538230-5 1989 A similar increase in hydroxyl radical production in the presence of rhTNF was also detected with TNF-sensitive human myosarcoma-derived KYM cells, but no such increase was detected with TNF insensitive human embryonic lung fibroblast HEL cells. Hydroxyl Radical 22-38 tumor necrosis factor Homo sapiens 71-74 2538230-5 1989 A similar increase in hydroxyl radical production in the presence of rhTNF was also detected with TNF-sensitive human myosarcoma-derived KYM cells, but no such increase was detected with TNF insensitive human embryonic lung fibroblast HEL cells. Hydroxyl Radical 22-38 tumor necrosis factor Homo sapiens 98-101 2538230-6 1989 The results show that rhTNF induces increased hydroxyl radical production in TNF-sensitive cells, and suggest that this plays an important role in the mechanism of tumor cell killing by rhTNF. Hydroxyl Radical 46-62 tumor necrosis factor Homo sapiens 24-27 2538353-2 1989 The elastase-inhibitory activity of alpha 1-antiproteinase is inactivated by hydroxyl radicals (.OH) generated by pulse radiolysis or by reaction of iron ions with H2O2 in the presence of superoxide or ascorbate. Hydroxyl Radical 77-94 serpin family A member 1 Homo sapiens 36-58 2914330-5 1989 These results clearly indicate that electron-donating groups, such as hydroxyl or primary, secondary and tertiary amines, are essential for binding of azo dye carcinogens to liver microsomal cytochrome P-450 and, by implication, their enzymic reduction. Hydroxyl Radical 70-78 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 191-207 2550152-11 1989 The formation of the hydroxyl radical was inhibited by superoxide dismutase (SOD) and catalase. Hydroxyl Radical 21-37 catalase Homo sapiens 86-94 2553551-4 1989 To test this hypothesis, FABP was examined for scavenging against free radicals such as the superoxide anion (O2-), hydroxyl radical (OH.) Hydroxyl Radical 116-132 glutamic-oxaloacetic transaminase 2 Homo sapiens 25-29 2647629-7 1989 The use of scavengers of reactive oxygen reduction intermediates indicated that hydrogen peroxide, superoxide anion and singlet oxygen, but apparently not hydroxyl radicals, were involved in parasite killing modulated by rIL-4. Hydroxyl Radical 155-172 interleukin 4 Rattus norvegicus 221-226 2517876-2 1989 The stereoconfigurations of the C-12 hydroxyl isomers were determined by incubation with potato 5-lipoxygenase. Hydroxyl Radical 37-45 5-lipoxygenase Solanum tuberosum 96-110 2545550-12 1989 Hydroxyl scavengers (formate, mannitol or glucose) alone produced little or no (less than 10%) inhibition, but inhibited by 30% in the presence of catalase + superoxide dismutase. Hydroxyl Radical 0-8 catalase Homo sapiens 147-155 2806954-2 1989 In such systems hydroxyl radical formation has also been demonstrated by its ability to degrade deoxyribose subsequent to the release of iron from the porphyrin ring of the myoglobin. Hydroxyl Radical 16-32 myoglobin Homo sapiens 173-182 2848219-0 1988 A model for hormone receptor binding to the mouse mammary tumour virus regulatory element based on hydroxyl radical footprinting. Hydroxyl Radical 99-115 nuclear receptor subfamily 4, group A, member 1 Mus musculus 12-28 2484701-2 1989 The first step in the transformation of the sydnonimine SIN-1 is the hydroxyl ion-dependent conversion to SIN-1A that occurs almost immediately at neutral pH. Hydroxyl Radical 69-77 MAPK associated protein 1 Homo sapiens 56-61 2561361-12 1989 Non-proteolytic means apparently provide a potent activation pathway of neutrophil collagenase in vivo and the hydroxyl radical was identified to be one of the potent activating oxidants. Hydroxyl Radical 111-127 matrix metallopeptidase 8 Homo sapiens 72-94 3137698-5 1988 The microsomal production of DCAP can be inhibited by the addition of specific antibodies to cytochrome P-450d, thus indicating that the removal of the nitro group and subsequent replacement with a hydroxyl group was initiated by cytochrome P-450d in the mixed-function oxidase system. Hydroxyl Radical 198-206 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 93-110 2845869-0 1988 [Implication of hydroxyl radical production in the killing of tumor cells by recombinant human tumor necrosis factor]. Hydroxyl Radical 16-32 tumor necrosis factor Homo sapiens 95-116 2845869-1 1988 We investigated the effect of recombinant human tumor necrosis factor (rhTNF) on hydroxyl radical production by established cell lines in vitro, and its implication in the killing of tumor cells by rhTNF. Hydroxyl Radical 81-97 tumor necrosis factor Homo sapiens 48-69 2845869-2 1988 During incubation of TNF sensitive mouse tumorigenic fibroblast L-M cells in the presence of rhTNF, hydroxyl radical production detected by the evolution of methane gas from dimethyl sulfoxide increased gradually, at 18 hours reached 1.8 times of that in the absence of rhTNF. Hydroxyl Radical 100-116 tumor necrosis factor Mus musculus 21-24 2845869-5 1988 The increase of hydroxyl radical production stimulated by rhTNF was also detected in TNF sensitive human myosarcoma derived KYM cells as well as in L-M cells, but no change was detected in TNF insensitive human embryonic lung fibroblast HEL cells. Hydroxyl Radical 16-32 tumor necrosis factor Homo sapiens 60-63 2845869-5 1988 The increase of hydroxyl radical production stimulated by rhTNF was also detected in TNF sensitive human myosarcoma derived KYM cells as well as in L-M cells, but no change was detected in TNF insensitive human embryonic lung fibroblast HEL cells. Hydroxyl Radical 16-32 tumor necrosis factor Homo sapiens 85-88 2840749-6 1988 Xanthine oxidase inhibitors, hydroxyl radical scavengers, and complement depletion diminished the generation of C5a activity at the burn site, whereas neutrophil depletion was without effect. Hydroxyl Radical 29-45 complement C5 Rattus norvegicus 112-115 2840749-8 1988 The catalase sensitivity and iron dependency of C5a generation suggest that hydroxyl radical may be related to complement activation and C5a appearance. Hydroxyl Radical 76-92 complement C5 Rattus norvegicus 48-51 2840749-8 1988 The catalase sensitivity and iron dependency of C5a generation suggest that hydroxyl radical may be related to complement activation and C5a appearance. Hydroxyl Radical 76-92 complement C5 Rattus norvegicus 137-140 2849797-4 1988 By consuming hydrogen peroxide, the release of myeloperoxidase limits the magnitude of hydroxyl radical production. Hydroxyl Radical 87-103 myeloperoxidase Homo sapiens 47-62 3137698-5 1988 The microsomal production of DCAP can be inhibited by the addition of specific antibodies to cytochrome P-450d, thus indicating that the removal of the nitro group and subsequent replacement with a hydroxyl group was initiated by cytochrome P-450d in the mixed-function oxidase system. Hydroxyl Radical 198-206 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 230-247 2839377-1 1988 The hydroxyl radical has been spin trapped in microsomal and purified NADPH-cytochrome P-450 reductase systems in the presence of adriamycin, daunomycin and mitomycin C. Hydroxyl Radical 4-20 cytochrome p450 oxidoreductase Homo sapiens 70-102 3415646-2 1988 The decreased rates of hydroxyl-radical generation at lower O2 concentrations correlates with lower rates of production of H2O2, the precursor of hydroxyl radical, whereas the decreased rates at elevated O2 concentrations correlate with lower rates (relative to 20% O2) of activity of NADPH-cytochrome P-450 reductase, which reduces iron and is responsible for redox cycling of iron by the microsomes. Hydroxyl Radical 23-39 cytochrome p450 oxidoreductase Rattus norvegicus 285-317 2835006-4 1988 In the presence of cytochrome c the methylene blue caused a sharp decrease in both paraquat-induced superoxide and hydroxyl radical production. Hydroxyl Radical 115-131 cytochrome c, somatic Homo sapiens 19-31 2843167-0 1988 Superoxide dismutase enhances the formation of hydroxyl radicals in the reaction of 3-hydroxyanthranilic acid with molecular oxygen. Hydroxyl Radical 47-64 superoxide dismutase 1 Homo sapiens 0-20 2843167-1 1988 Superoxide dismutase (SOD) enhanced the formation of hydroxyl radicals, which were detected by using the e.s.r. Hydroxyl Radical 53-70 superoxide dismutase 1 Homo sapiens 0-20 2843167-1 1988 Superoxide dismutase (SOD) enhanced the formation of hydroxyl radicals, which were detected by using the e.s.r. Hydroxyl Radical 53-70 superoxide dismutase 1 Homo sapiens 22-25 2843167-3 1988 The hydroxyl-radical formation enhanced by SOD was inhibited by catalase and desferrioxamine, and stimulated by EDTA and diethylenetriaminepenta-acetic acid, suggesting that both hydrogen peroxide and iron ions participate in the reaction. Hydroxyl Radical 4-20 superoxide dismutase 1 Homo sapiens 43-46 2843167-4 1988 The hydroxyl-radical formation enhanced by SOD may be considered to proceed via the following steps. Hydroxyl Radical 4-20 superoxide dismutase 1 Homo sapiens 43-46 2833279-3 1988 At small amounts of Fe(III)-EDTA (1-5 microM), the enhanced oxidase activity was manifested in a much higher dependency on P-450 LM2 for the production of hydroxyl radicals, as determined by the oxidation of dimethylsulphoxide (Me2SO) or 2-keto-4-thiomethylbutyric acid (KMBA), in the vesicular than in the micellar system. Hydroxyl Radical 155-172 cytochrome P450 2B4 Oryctolagus cuniculus 123-132 2833279-5 1988 The data indicate that in the presence of no or small amounts of chelated iron in negatively-charged membranous systems, most of the hydrogen peroxide and superoxide anions necessary for generation of hydroxyl radicals, are produced by cytochrome P-450 LM2. Hydroxyl Radical 201-218 cytochrome P450 2B4 Oryctolagus cuniculus 236-256 2447244-10 1988 Similarly, the effect of PLA2 was also inhibited by methanol (1 mM), a scavenger of the hydroxyl radical, and by catalase. Hydroxyl Radical 88-104 phospholipase A2 group IB Rattus norvegicus 25-29 2831086-1 1988 The phosphate/pyrophosphate translocase protein (T2) of the hepatic microsomal glucose-6-phosphatase system was identified and then purified using antibodies raised against the rat mitochondrial phosphate/hydroxyl ion antiport protein. Hydroxyl Radical 205-213 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 79-100 2826473-12 1988 Ferredoxin:NADP+ oxidoreductase reduces ferredoxin, which in turn is responsible for the reduction of oxygen to hydrogen peroxide and ultimately the hydroxyl radical. Hydroxyl Radical 149-165 thioredoxin reductase 1 Homo sapiens 17-31 2828121-0 1988 Iron-dependent hydroxyl radical formation and DNA damage from a novel metabolite of the clinically active antitumor drug VP-16. Hydroxyl Radical 15-31 host cell factor C1 Homo sapiens 121-126 3234862-2 1988 This damage can be substantially prevented by catalase, metal chelators and some scavengers of the hydroxyl radical. Hydroxyl Radical 99-115 catalase Homo sapiens 46-54 3282882-1 1988 Using hydroxyl radical footprinting and ethylation interference experiments, we have determined the backbone contacts made by the entire LexA repressor and its amino-terminal fragment with the recA operator DNA. Hydroxyl Radical 6-22 RAD51 recombinase Homo sapiens 193-197 3282882-9 1988 A quantification of the hydroxyl radical footprints allowed us to compare further the affinity of the LexA repressor for the recA operator with that of its isolated DNA binding domain. Hydroxyl Radical 24-40 RAD51 recombinase Homo sapiens 125-129 2854107-4 1988 Detection of hydroxyl radicals can be decreased by transferrin or by .OH scavengers (mannitol, arginine, phenylalanine) but not by urea. Hydroxyl Radical 13-30 inhibitor of carbonic anhydrase Equus caballus 51-62 2834428-0 1988 Cytocidal mechanism of TNF: effects of lysosomal enzyme and hydroxyl radical inhibitors on cytotoxicity. Hydroxyl Radical 60-76 tumor necrosis factor Homo sapiens 23-26 2855734-2 1988 This degradation appeared to involve hydroxyl radicals since the damage was substantially reduced by the presence of catalase, superoxide dismutase, scavengers of the hydroxyl radical and metal chelators. Hydroxyl Radical 37-54 catalase Homo sapiens 117-125 2855734-2 1988 This degradation appeared to involve hydroxyl radicals since the damage was substantially reduced by the presence of catalase, superoxide dismutase, scavengers of the hydroxyl radical and metal chelators. Hydroxyl Radical 37-53 catalase Homo sapiens 117-125 3384343-5 1988 The inhibitory effects of sodium azide, methanol, mannitol, SOD, and catalase suggest an oxygen-dependent mechanism of strand-break production, probably involving hydroxyl radicals. Hydroxyl Radical 163-180 catalase Homo sapiens 69-77 2834428-1 1988 The participation of lysosomal enzymes, hydroxyl radicals, and mitochondrial respiration in the cytocidal effect of TNF on tumor cells was investigated. Hydroxyl Radical 40-57 tumor necrosis factor Homo sapiens 116-119 2834428-2 1988 The cytotoxicity of TNF on L-M cells was clearly reduced by lysosomotropic agents, DMSO (hydroxyl radical scavenger), NDGA (lipoxygenase inhibitor), and sodium azide (mitochondrial respiration inhibitor). Hydroxyl Radical 89-105 tumor necrosis factor Homo sapiens 20-23 2834428-3 1988 The results suggest that lysosomal enzyme and hydroxyl radicals play an important triggering role in the destruction of tumor cells by TNF, and that the process of destruction might require ATP. Hydroxyl Radical 46-63 tumor necrosis factor Homo sapiens 135-138 3151020-13 1988 The nitrogen atom of the SCN- ion is 1.9 A from the zinc ion but shifted 1.3 A with respect to the hydroxyl ion in the native structure and at van der Waals" distance from the O gamma l atom of Thr-199. Hydroxyl Radical 99-107 sorcin Homo sapiens 25-28 2823829-4 1987 This damage is substantially inhibited by the enzyme catalase and scavengers of the hydroxyl radical such as formate, mannitol and thiourea. Hydroxyl Radical 84-100 catalase Homo sapiens 53-61 2823714-0 1987 The role of hydroxyl radicals in irreversible inactivation of lactoperoxidase by excess H2O2. Hydroxyl Radical 12-29 lactoperoxidase Homo sapiens 62-77 2824562-8 1987 Most of the red cell inhibition of hydroxyl radical production, and all the inhibition of methionine oxidation, was prevented by blocking intracellular catalase with aminotriazole. Hydroxyl Radical 35-51 catalase Homo sapiens 152-160 3036002-0 1987 Production of 4-hydroxypyrazole from the interaction of the alcohol dehydrogenase inhibitor pyrazole with hydroxyl radical. Hydroxyl Radical 106-122 aldo-keto reductase family 1 member A1 Homo sapiens 60-81 3605340-3 1987 The objective of this study is to characterize the interaction between purified gastric mucin and hydroxyl radicals generated from the interaction between ferric iron and ascorbic acid. Hydroxyl Radical 98-106 LOC100508689 Homo sapiens 88-93 3040748-2 1987 Using the spin trap 5,5-dimethyl-1-pyrroline-N-oxide, the principle spin adduct observed is DMPO-OH (trapped hydroxyl radical). Hydroxyl Radical 109-125 spindlin 1 Homo sapiens 10-14 3040748-2 1987 Using the spin trap 5,5-dimethyl-1-pyrroline-N-oxide, the principle spin adduct observed is DMPO-OH (trapped hydroxyl radical). Hydroxyl Radical 109-125 spindlin 1 Homo sapiens 68-72 3605340-4 1987 We found that both native and pronase-treated mucin effectively scavenged hydroxyl radical and that the scavenging properties were not significantly different. Hydroxyl Radical 74-90 LOC100508689 Homo sapiens 46-51 3605340-8 1987 These data suggest that hydroxyl radicals derived from the iron-catalyzed decomposition of hydrogen peroxide are responsible for the depolymerization of native mucin. Hydroxyl Radical 24-41 LOC100508689 Homo sapiens 160-165 3036002-1 1987 Pyrazole, an effective inhibitor of alcohol dehydrogenase, was previously shown to be a scavenger of the hydroxyl radical. Hydroxyl Radical 105-121 aldo-keto reductase family 1 member A1 Homo sapiens 36-57 2441682-9 1987 These results indicate that nuclear NADPH-cytochrome P-450 reductase redox cycles the bleomycin-Fe(III/II) complex and that the reduced complex activates oxygen, whereby hydroxyl radicals are formed which damage the deoxyribose of nuclear DNA. Hydroxyl Radical 170-187 cytochrome p450 oxidoreductase Homo sapiens 36-68 3030871-9 1987 The data suggest that Na/H exchange is primarily responsible for the regulation of pHi over a wide range of pHo, although the specific pHi and the range of regulation are affected by the activity of the Cl/OH (HCO3) exchanger; the movement of protons or hydroxyl ions, or both, across gland cell membranes appears to be mediated under most circumstances by these two exchangers. Hydroxyl Radical 254-262 glucose-6-phosphate isomerase Oryctolagus cuniculus 83-86 3030871-9 1987 The data suggest that Na/H exchange is primarily responsible for the regulation of pHi over a wide range of pHo, although the specific pHi and the range of regulation are affected by the activity of the Cl/OH (HCO3) exchanger; the movement of protons or hydroxyl ions, or both, across gland cell membranes appears to be mediated under most circumstances by these two exchangers. Hydroxyl Radical 254-262 glucose-6-phosphate isomerase Oryctolagus cuniculus 135-138 2881544-2 1987 This mechanism of guanylate cyclase activation is not blocked by scavengers for superoxide anion or hydroxyl radical, but is selectively inhibited by methylene blue, inactivation of catalase and ethanol. Hydroxyl Radical 100-116 guanylate cyclase Bos taurus 18-35 2881544-2 1987 This mechanism of guanylate cyclase activation is not blocked by scavengers for superoxide anion or hydroxyl radical, but is selectively inhibited by methylene blue, inactivation of catalase and ethanol. Hydroxyl Radical 100-116 catalase Bos taurus 182-190 3579983-11 1987 Since catalase and hydroxyl radical scavengers inhibited NADPH-dependent but not LAHP-dependent lipid peroxidation, it is concluded that the hydroxyl radical derived from H2O2 is the initiating active-oxygen species in the enzymatic reaction but not in the autocatalytic reaction. Hydroxyl Radical 141-157 catalase Homo sapiens 6-14 3032157-1 1987 Are lactoferrin and transferrin promoters of hydroxyl-radical generation? Hydroxyl Radical 45-61 transferrin Homo sapiens 20-31 3032157-2 1987 Apo-lactoferrin and apo-transferrin protect against iron-ion-dependent hydroxyl-radical (.OH) generation from H2O2 in the presence of superoxide radicals or ascorbic acid at pH 7.4, whether the necessary iron is added as ionic iron or as ferritin. Hydroxyl Radical 71-87 transferrin Homo sapiens 24-35 3697139-1 1987 Oligoribonucleotides were obtained without contamination of 2"-5" linked regioisomers by means of polymer support when Thp group was employed as 2"-hydroxyl protecting group. Hydroxyl Radical 148-156 uromodulin Homo sapiens 119-122 2833323-7 1987 These data suggest that catalase, hydroxyl radical scavengers, and iron chelators protect chemotactically stimulated neutrophils from autotoxicity caused by neutrophil-derived hydrogen peroxide and its iron-catalyzed conversion product, hydroxyl radical. Hydroxyl Radical 237-253 catalase Rattus norvegicus 24-32 3023612-0 1986 Spin trapping of superoxide and hydroxyl radicals with substituted pyrroline 1-oxides. Hydroxyl Radical 32-49 spindlin 1 Rattus norvegicus 0-4 3022748-0 1986 Differential effects of the cytochrome P-450/reductase ratio on the oxidation of ethanol and the hydroxyl radical scavenging agent 2-keto-4-thiomethylbutyric acid (KMBA). Hydroxyl Radical 97-113 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 28-54 3022748-1 1986 NADPH-cytochrome P-450 reductase catalyzes a low rate of oxidation of hydroxyl radical scavenging agents such as ethanol and 2-keto-4-thiomethylbutyric acid (KMBA), in a reaction markedly stimulated by the addition of ferric-EDTA. Hydroxyl Radical 70-86 cytochrome p450 oxidoreductase Homo sapiens 0-32 3023612-4 1986 Hyperfine coupling constants for the spin trapping of superoxide and hydroxyl radical by the various nitrones were determined. Hydroxyl Radical 69-85 spindlin 1 Rattus norvegicus 37-41 3642198-2 1986 It is proposed that the cytotoxic effect of TNF against tumours may be exerted in like manner, by stimulating the generation of hydroxyl radicals which leads in turn to an upset of energy metabolism, and hence to cell death. Hydroxyl Radical 128-145 tumor necrosis factor Homo sapiens 44-47 3016031-8 1986 It is concluded that under conditions where neutrophils release myeloperoxidase as well as superoxide and hydrogen peroxide, breakdown of hydrogen peroxide by myeloperoxidase would make conditions unfavorable for hydroxyl radical production. Hydroxyl Radical 213-229 myeloperoxidase Homo sapiens 159-174 2825313-6 1986 MPO-independent oxidant generation in neutrophils and macrophages involves the generation of highly toxic species derived from the interaction of O2- and H2O2, such as hydroxyl radical and singlet oxygen. Hydroxyl Radical 168-184 myeloperoxidase Homo sapiens 0-3 3016031-0 1986 Myeloperoxidase as an effective inhibitor of hydroxyl radical production. Hydroxyl Radical 45-61 myeloperoxidase Homo sapiens 0-15 3016031-3 1986 Purified myeloperoxidase, and neutrophils stimulated with fMet-Leu-Phe and cytochalasin B, strongly inhibited this hydroxyl radical production in a concentration-dependent manner. Hydroxyl Radical 115-131 myeloperoxidase Homo sapiens 9-24 3016031-7 1986 With neutrophils stimulated with phorbol myristate acetate, which release very little myeloperoxidase, hydroxyl radical production was enhanced due to the additional superoxide produced by the cells. Hydroxyl Radical 103-119 myeloperoxidase Homo sapiens 86-101 3090544-0 1986 Hydroxyl radical "footprinting": high-resolution information about DNA-protein contacts and application to lambda repressor and Cro protein. Hydroxyl Radical 0-16 cro Escherichia virus Lambda 128-131 3090544-5 1986 For example, hydroxyl radical footprints of the bacteriophage lambda repressor and Cro protein show directly that these proteins are bound to only one side of the DNA helix. Hydroxyl Radical 13-29 cro Escherichia virus Lambda 83-86 3090544-6 1986 Additional contacts of lambda repressor and Cro protein with DNA, not observed by other chemical footprinting methods, are revealed by hydroxyl radical footprinting. Hydroxyl Radical 135-151 cro Escherichia virus Lambda 44-47 3735313-3 1986 In contrast, cis-3-[4-(2-heptyloxy)-2-hydroxyphenyl]cyclohexanol (8), the analogue in which the pyrrolo ring is replaced by a hydroxyl group, had an ED50 of 8.3 mg/kg, sc, in the same model. Hydroxyl Radical 126-134 suppressor of cytokine signaling 3 Homo sapiens 13-18 3017335-2 1986 Oxidation of imidazole ring by the ascorbic acid-copper ion system was considerably site-specific and assumed to be initiated by the addition of the hydroxyl radical (.0H) at C-2 position in the imidazole ring. Hydroxyl Radical 149-165 complement C2 Homo sapiens 175-178 2825313-6 1986 MPO-independent oxidant generation in neutrophils and macrophages involves the generation of highly toxic species derived from the interaction of O2- and H2O2, such as hydroxyl radical and singlet oxygen. Hydroxyl Radical 168-184 immunoglobulin kappa variable 1D-39 Homo sapiens 146-158 3957930-4 1986 Microsomes from 3-methylcholanthrene-treated rats and cytochrome P-450c in the reconstituted system form exclusively the diol expoxide-1 diastereomer, in which the benzylic hydroxyl group and oxirane oxygen are cis to each other, from the (+)-(3S,4S)-dihydrodiol. Hydroxyl Radical 173-181 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 54-71 3544110-3 1986 Since pretreatment of experimental animals with catalase, iron chelators or scavengers of hydroxyl radical results in protection from pulmonary damage, it is assumed that the hydroxyl radical is the most likely mediator of phagocyte-dependent acute lung injury. Hydroxyl Radical 175-191 catalase Homo sapiens 48-56 3008728-0 1986 Formation of superoxide and hydroxyl radicals from 1-methyl-4-phenylpyridinium ion (MPP+): reductive activation by NADPH cytochrome P-450 reductase. Hydroxyl Radical 28-45 cytochrome p450 oxidoreductase Homo sapiens 115-147 3489212-4 1986 This protective effect of catalase indicates that hydrogen peroxide (H2O2) and/or conversion products of H2O2 (e.g., hydroxyl radical, hypochlorous acid) may play an important role in the development of experimental phacoanaphylactic endophthalmitis. Hydroxyl Radical 117-133 catalase Rattus norvegicus 26-34 3017277-6 1986 The involvement of lipoxygenase in the production of hydroxyl radical was demonstrated by the trapping of the radical with DMPO in a reaction mixture of soybean lipoxygenase and arachidonic acid (AA). Hydroxyl Radical 53-69 linoleate 9S-lipoxygenase-4 Glycine max 19-31 3017277-6 1986 The involvement of lipoxygenase in the production of hydroxyl radical was demonstrated by the trapping of the radical with DMPO in a reaction mixture of soybean lipoxygenase and arachidonic acid (AA). Hydroxyl Radical 53-69 linoleate 9S-lipoxygenase-4 Glycine max 161-173 3017277-7 1986 These findings support our previous postulation that the metabolism of AA via the lipoxygenase pathway is a source of hydroxyl radical in stimulated neutrophils. Hydroxyl Radical 118-134 linoleate 9S-lipoxygenase-4 Glycine max 82-94 3940629-5 1986 Three adducts (MS1, MS2, MS3) bound to the immobilized boronate column indicating that they contained cis-vicinal hydroxyl groups, a configuration which would result from reaction of 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydroBaP (anti-BaPDE) with DNA. Hydroxyl Radical 114-122 actin-binding Rho activating protein Rattus norvegicus 15-18 4020882-0 1985 Involvement of hydrogen peroxide and hydroxyl radical in the "oxygen paradox": reduction of creatine kinase release by catalase, allopurinol or deferoxamine, but not by superoxide dismutase. Hydroxyl Radical 37-53 catalase Homo sapiens 119-127 2998382-2 1985 The effects of superoxide dismutase, catalase, and hydroxyl radical scavengers on the reaction provide evidence for superoxide formation as the rate determing step followed by fast reactions that involve peroxide and hydroxyl radical. Hydroxyl Radical 217-233 catalase Homo sapiens 37-45 3866515-2 1985 Replacement of the 3-hydroxyl of T-2 with hydrogen caused a 24-fold decrease in activity, whereas acetylation resulted in a 500-to 1,000-fold decrease. Hydroxyl Radical 20-29 solute carrier family 25 member 5 Homo sapiens 33-36 3866515-7 1985 From these results, we suggest that the 3-hydroxyl moiety is essential for T-2 to exhibit such high activity on eucaryotic cell protein synthesis and that modification at the C-3 position decreases but does not eliminate this activity. Hydroxyl Radical 42-50 solute carrier family 25 member 5 Homo sapiens 75-78 3879767-2 1985 Recently, metallothionein has been shown to be an efficient free radical scavenger, and induction by interleukin 1 may be part of a protective response to minimize damage by hydroxyl radicals. Hydroxyl Radical 174-191 interleukin 1 alpha Homo sapiens 101-114 4004878-4 1985 The fact that HHT is an excellent substrate for 15-hydroxyprostaglandin dehydrogenase suggest that HHT may have profound unrecognized biological actions and its inactivation may be via oxidation of the hydroxyl group. Hydroxyl Radical 202-210 carbonyl reductase 1 Homo sapiens 48-85 2989680-2 1985 Incidences of chromosomal aberrations by CdCl2 were partially or fully reduced by the presence of catalase, mannitol (a scavenger of hydroxyl radicals) and butylated hydroxytoluene (BHT, an antioxidant). Hydroxyl Radical 133-150 catalase Cricetulus griseus 98-106 2987038-4 1985 Since hydrogen peroxide and a ferric-EDTA chelate are themselves a hydroxyl radical-generating system, it follows that SOD must also protect against damage done by this reaction. Hydroxyl Radical 67-83 superoxide dismutase 1 Homo sapiens 119-122 2982854-10 1985 Stimulation of lipid peroxidation but inhibition of hydroxyl radical formation by catalase suggests that, in this system, initiation is not via an iron-catalyzed Haber-Weiss reaction. Hydroxyl Radical 52-60 catalase Homo sapiens 82-90 3882888-4 1985 Studies with catalase, superoxide dismutase (SOD), mannitol, and chelated iron suggested that hydroxyl radical (OH X) was probably responsible for the initiation of lipid peroxidation. Hydroxyl Radical 94-110 catalase Rattus norvegicus 13-21 2409975-0 1985 Catalase enhances damage to DNA by bleomycin-iron(II): the role of hydroxyl radicals. Hydroxyl Radical 67-84 catalase Homo sapiens 0-8 2409975-4 1985 These findings suggest that catalase removes hydrogen peroxide and in so doing prevents loss of ferrous ions and formation of hydroxyl radicals (OH.) Hydroxyl Radical 126-143 catalase Homo sapiens 28-36 2983734-4 1985 Hydroxyl radical spin adduct formation was not inhibited by the metal ion chelators diethylenetriaminepenta-acetic acid (DETAPAC) or desferrioxamine, or by addition of superoxide dismutase but could be inhibited by addition of catalase and high concentration of the hydroxyl radical scavengers mannitol and N-acetylcysteine. Hydroxyl Radical 0-16 catalase Rattus norvegicus 227-235 2859164-0 1985 Evaluation of the role of free hydroxyl radicals in the cytochrome P-450-catalyzed oxidation of benzene and cyclohexanol. Hydroxyl Radical 31-48 cytochrome P-450 Oryctolagus cuniculus 56-72 2983184-7 1985 Analogs that lack the C-11-hydroxyl group are relatively inefficient at oxygen reduction, hydroxyl radical formation, and DNA cleavage. Hydroxyl Radical 90-106 RNA polymerase III subunit K Homo sapiens 22-26 2981536-5 1985 The ability of desferal to react with hydroxyl radical (k2 approximately 10(10) M-1 s-1) is a far more likely source of error in the interpretation of results using this chelating agent. Hydroxyl Radical 38-54 tumor associated calcium signal transducer 2 Homo sapiens 80-87 3157637-5 1985 Since transferrin (iron) is known to catalyze the formation of hydroxyl radicals we hypothesize that the Tf C2 variant is more efficient in promoting radical formation and thereby cell damage. Hydroxyl Radical 63-80 transferrin Homo sapiens 6-17 3919527-3 1985 The complete inhibition of the process by hydroxyl radical scavengers, superoxide dismutase and catalase, indicated an iron-catalyzed Haber-Weiss reaction for the generation of hydroxyl radicals that subsequently react with the nucleic acid. Hydroxyl Radical 42-58 catalase Oryctolagus cuniculus 96-104 3919527-3 1985 The complete inhibition of the process by hydroxyl radical scavengers, superoxide dismutase and catalase, indicated an iron-catalyzed Haber-Weiss reaction for the generation of hydroxyl radicals that subsequently react with the nucleic acid. Hydroxyl Radical 177-194 catalase Oryctolagus cuniculus 96-104 2863291-0 1985 Effects of hydroxyl radical scavengers KCN and CO on ultraviolet light-induced activation of crude soluble guanylate cyclase. Hydroxyl Radical 11-27 guanylate cyclase Bos taurus 107-124 3922881-3 1985 We have shown that (1) hydroxyl radical scavenger (DMSO) abolished IL-2 production, (2) inhibitor of the lipoxygenase pathway (NDGA) strongly decreased IL-2 production, (3) thin layer chromatography demonstrated a polar metabolite(s) of AA in increasing amounts according to the following order: non-irradiated resting cells, non-irradiated stimulated cells, irradiated resting cells, and irradiated stimulated cells. Hydroxyl Radical 23-39 interleukin 2 Homo sapiens 67-71 2864680-3 1985 The substitution of tyrosine for phenylalanine at position three resulted in a large increase in opiate receptor affinity which may be related to the known requirement for a phenolic hydroxyl moiety in the rigid opiate and enkephalin systems. Hydroxyl Radical 183-191 proenkephalin Rattus norvegicus 223-233 3013978-1 1985 Radiolytically generated hydroxyl radicals degrade cytochrome c. Hydroxyl Radical 25-42 cytochrome c, somatic Homo sapiens 51-63 6094553-6 1984 2) This generation of hydroxyl radical is greatly decreased by prior oxidation of the hemoglobin, equilibration of hemoglobin with carbon monoxide, or addition of catalase, while added superoxide dismutase has little effect. Hydroxyl Radical 22-38 catalase Homo sapiens 163-171 6094553-10 1984 5) The addition of sufficient haptoglobin (the plasma hemoglobin-binding protein) suppresses both hemoglobin-driven hydroxyl radical and malondialdehyde generation. Hydroxyl Radical 116-132 haptoglobin Homo sapiens 30-41 6523442-10 1984 Spectrophotometric titrations of the phenolic hydroxyl groups suggest that the structural environments of tyrosyl groups for both unmodified and modified thrombin containing one oxidized tryptophan residue, are similar. Hydroxyl Radical 46-54 coagulation factor II, thrombin Bos taurus 154-162 6093705-2 1984 generated by xanthine oxidase and glutathione reductase to give H2O2-dependent hydroxyl radical production was investigated. Hydroxyl Radical 79-95 glutathione-disulfide reductase Homo sapiens 34-55 6083770-9 1984 These oxygen species function as oxidizing agents for AA metabolism and amplify the production of hydroxyl radical along the lipoxygenase (and possibly cyclooxygenase) pathway(s). Hydroxyl Radical 98-114 linoleate 9S-lipoxygenase-4 Glycine max 125-137 6091667-3 1984 Inhibition by a variety of hydroxyl radical scavengers and by catalase implicates a radical species with properties similar to the hydroxyl radical. Hydroxyl Radical 131-147 catalase Homo sapiens 62-70 6092375-0 1984 The effect of human serum transferrin and milk lactoferrin on hydroxyl radical formation from superoxide and hydrogen peroxide. Hydroxyl Radical 62-78 transferrin Homo sapiens 26-37 6092375-4 1984 Partially saturated transferrin and lactoferrin present in normal subjects may protect cells from damage by binding iron that might catalyze hydroxyl radical formation from superoxide and hydrogen peroxide. Hydroxyl Radical 141-157 transferrin Homo sapiens 20-31 6331179-6 1984 Hydroxyl radical generation was catalyzed by the addition of 2.4 microM Fe3+-loaded transferrin to the system. Hydroxyl Radical 0-16 serotransferrin Oryctolagus cuniculus 84-95 6331321-1 1984 Uninduced rat liver microsomes and NADPH-Cytochrome P-450 reductase, purified from phenobarbital-treated rats, catalyzed an NADPH-dependent oxidation of hydroxyl radical scavenging agents. Hydroxyl Radical 153-169 cytochrome p450 oxidoreductase Rattus norvegicus 35-67 6331321-7 1984 Catalase inhibited potently the oxidation of scavengers under all conditions, suggesting that H2O2 was the precursor of the hydroxyl radical in these systems. Hydroxyl Radical 124-140 catalase Rattus norvegicus 0-8 6330172-2 1984 The mechanism of action of gastrin was investigated using cytochemical quantitation of hydroxyl ion production (HIP) in guinea pig gastric oxyntic mucosa. Hydroxyl Radical 87-95 gastrin Cavia porcellus 27-34 6332111-1 1984 Various hydroxyl radical scavengers markedly inhibited phorbol myristate acetate (PMA)-induced lymphotoxin (LT) production by a human T cell hybridoma, AC5-8. Hydroxyl Radical 8-24 adenylate cyclase 5 Homo sapiens 152-157 6548142-3 1984 This effect was reversed by inclusion of superoxide dismutase, catalase or diethylenetriaminepentaacetic acid in the incubations suggesting that hydroxyl radicals were the active species. Hydroxyl Radical 145-162 catalase Homo sapiens 63-71 6327680-2 1984 The presence of cytochrome P-450 in the membranes resulted in 4-8-fold higher rates of O-2, H2O2, and hydroxyl radical production, indicating that the oxycytochrome P-450 complex constitutes the major source for superoxide anions liberated in the system, giving as a consequence hydrogen peroxide and also, subsequently, hydroxyl radicals formed in an iron-catalyzed Haber-Weiss reaction. Hydroxyl Radical 102-118 cytochrome P-450 Oryctolagus cuniculus 16-32 6327680-2 1984 The presence of cytochrome P-450 in the membranes resulted in 4-8-fold higher rates of O-2, H2O2, and hydroxyl radical production, indicating that the oxycytochrome P-450 complex constitutes the major source for superoxide anions liberated in the system, giving as a consequence hydrogen peroxide and also, subsequently, hydroxyl radicals formed in an iron-catalyzed Haber-Weiss reaction. Hydroxyl Radical 321-338 cytochrome P-450 Oryctolagus cuniculus 16-32 6324859-8 1984 The substitutions of the 2"- or 3"-hydrogen for hydroxyl groups in the ribose moiety of this compound slightly affected its suitability as substrate for myokinase but had drastic effect in the case of adenylate deaminase. Hydroxyl Radical 48-56 adenylate kinase 1 Homo sapiens 153-162 6327680-7 1984 Horseradish peroxidase and scavengers of hydroxyl radicals inhibited the cytochrome P-450 LMeb -dependent ethanol oxidation both in the presence and in the absence of Fe-EDTA. Hydroxyl Radical 41-58 cytochrome P-450 Oryctolagus cuniculus 73-89 6329886-4 1984 Inhibition was observed by catalase, superoxide dismutase, and benzoic acid which is a typical hydroxyl radical scavenger. Hydroxyl Radical 95-111 catalase Homo sapiens 27-35 6323433-3 1984 In this present study, we have investigated the hypothesis that iron-catalyzed formation of hydroxyl radical (.OH) from superoxide anion radical (O-.2) and H2O2 requires the availability of at least one iron coordination site that is open or occupied by a readily dissociable ligand such as water. Hydroxyl Radical 92-108 immunoglobulin kappa variable 1D-39 Homo sapiens 146-150 6321237-3 1984 This damage is inhibited by scavengers of the hydroxyl radical, iron chelators and the specific proteins catalase and superoxide dismutase. Hydroxyl Radical 46-62 catalase Homo sapiens 105-113 6328179-0 1984 Spin trapping of superoxide and hydroxyl radicals. Hydroxyl Radical 32-49 spindlin 1 Homo sapiens 0-4 6315214-3 1983 These have been tentatively identified as bay-region anti-dihydrodiol epoxide: deoxyguanosine- and :deoxyadenosine adducts and a bay-region syn-dihydrodiol epoxide:deoxyadenosine-adduct (where the terms syn and anti define dihydrodiol-epoxides wherein the benzylic hydroxyl group and epoxide oxygen are cis or trans to one another, respectively). Hydroxyl Radical 265-273 joined toes Mus musculus 140-143 6316986-5 1983 The oxidation of t-butyl alcohol appeared to be mediated by hydroxyl radicals, or by a species with the oxidizing power of the hydroxyl radical, because the production of formaldehyde plus acetone was (a) inhibited by competing scavengers of the hydroxyl radical; (b) stimulated by the addition of iron-EDTA; and (c) inhibited by catalase. Hydroxyl Radical 127-143 catalase Homo sapiens 330-338 6296101-10 1983 The reductase-dependent oxidation of the scavengers was inhibited by superoxide dismutase, catalase, and competing hydroxyl radical scavenging agents suggesting that superoxide, hydrogen peroxide, and an oxygen radical with the oxidizing power of the hydroxyl radical played a role in these oxidations. Hydroxyl Radical 251-267 catalase Rattus norvegicus 91-99 6414352-3 1983 We found that either dimethyl thiourea, a scavenger of hydroxyl radical, or catalase, a scavenger of H2O2, protected cultured rabbit AM against hyperoxic damage, which suggests that H2O2 or an H2O2-derived product, such as hydroxyl radical, contribute to damage to AM from hyperoxia. Hydroxyl Radical 223-239 catalase Oryctolagus cuniculus 76-84 6307066-7 1983 The data support the hypothesis that hydroxyl radicals can dilate pial arterioles, since all the scavengers can ultimately reduce levels of hydroxyl generated by acetaldehyde plus xanthine oxidase. Hydroxyl Radical 37-54 xanthine dehydrogenase Mus musculus 180-196 6307066-7 1983 The data support the hypothesis that hydroxyl radicals can dilate pial arterioles, since all the scavengers can ultimately reduce levels of hydroxyl generated by acetaldehyde plus xanthine oxidase. Hydroxyl Radical 37-45 xanthine dehydrogenase Mus musculus 180-196 6301495-1 1983 Ascorbate reacts with methemoglobin to produce reactive oxygen species, most probably hydroxyl radicals. Hydroxyl Radical 86-103 hemoglobin subunit gamma 2 Homo sapiens 22-35 6301495-4 1983 This product is decomposed by hemoglobin to produce hydroxyl radicals according to a Fenton-like reaction in which ascorbate recycles methemoglobin to hemoglobin. Hydroxyl Radical 52-69 hemoglobin subunit gamma 2 Homo sapiens 134-147 6315070-3 1983 Superoxide generated either by adriamycin:ferredoxin reductase or by hypoxanthine:xanthine oxidase can promote the formation of hydroxyl radicals in the presence of soluble iron chelates. Hydroxyl Radical 128-145 ferredoxin reductase Homo sapiens 42-62 6315070-6 1983 Addition of double-stranded DNA to a mixture of adriamycin, ferredoxin reductase, NADPH and iron chelate inhibits formation of both superoxide and hydroxyl radicals. Hydroxyl Radical 147-164 ferredoxin reductase Homo sapiens 60-80 6311631-2 1983 The requirement of both catalase and superoxide dismutase to prevent rhodanese inactivation indicates that hydroxyl radical could be the most efficient inactivating agent. Hydroxyl Radical 107-123 catalase Homo sapiens 24-32 6313550-7 1983 Among six scavengers of hydroxyl radicals and singlet oxygen that were tested, L-methionine (20-80 mM) and L-histidine (40-80 mM) were capable of preventing MIF action. Hydroxyl Radical 24-41 macrophage migration inhibitory factor Cavia porcellus 157-160 6305716-0 1983 Superoxide-dependent formation of hydroxyl radical catalyzed by transferrin. Hydroxyl Radical 34-50 transferrin Homo sapiens 64-75 6305716-1 1983 Hydroxyl radicals are generated in the hypoxanthine-xanthine oxidase system in the presence of iron-saturated transferrin isolated from human serum. Hydroxyl Radical 0-17 transferrin Homo sapiens 110-121 6305935-0 1983 Hydroxyl radical-mediated, cytochrome P-450-dependent metabolic activation of benzene in microsomes and reconstituted enzyme systems from rabbit liver. Hydroxyl Radical 0-16 cytochrome P-450 Oryctolagus cuniculus 27-43 6305935-2 1983 It was found that the NADPH-dependent transformation of benzene to water-soluble metabolites and to phenol catalyzed by cytochrome P-450 LM2 in membrane vesicles was inhibited by catalase, horseradish peroxidase, superoxide dismutase, and hydroxyl radical scavengers such as mannitol, dimethyl sulfoxide, and catechol, indicating the participation of hydrogen peroxide, superoxide anions, and hydroxyl radicals in the process. Hydroxyl Radical 239-255 cytochrome P-450 Oryctolagus cuniculus 120-136 6305935-2 1983 It was found that the NADPH-dependent transformation of benzene to water-soluble metabolites and to phenol catalyzed by cytochrome P-450 LM2 in membrane vesicles was inhibited by catalase, horseradish peroxidase, superoxide dismutase, and hydroxyl radical scavengers such as mannitol, dimethyl sulfoxide, and catechol, indicating the participation of hydrogen peroxide, superoxide anions, and hydroxyl radicals in the process. Hydroxyl Radical 393-410 cytochrome P-450 Oryctolagus cuniculus 120-136 6305935-3 1983 The cytochrome P-450 LM2-dependent, hydroxyl radical-mediated destruction of deoxyribose was inhibited concomitantly to the benzene oxidation. Hydroxyl Radical 36-52 cytochrome P450 2B4 Oryctolagus cuniculus 4-24 6305935-5 1983 Biphenyl was formed in the reconstituted system, indicating the cytochrome P-450-dependent production of a hydroxycyclohexadienyl radical as a consequence of interactions between hydroxyl radicals and benzene. Hydroxyl Radical 179-196 cytochrome P-450 Oryctolagus cuniculus 64-80 6305935-7 1983 The results indicate that the microsomal cytochrome P-450-dependent oxidation of benzene is mediated by hydroxyl radicals formed in a modified Haber-Weiss reaction between hydrogen peroxide and superoxide anions and suggest that any cellular superoxide-generating system may be sufficient for the metabolic activation of benzene and structurally related compounds. Hydroxyl Radical 104-121 cytochrome P-450 Oryctolagus cuniculus 41-57 6296101-12 1983 These results suggest that an iron-catalyzed Haber-Weiss reaction might be involved in the mechanism by which purified cytochrome P-450 reductase mediates the oxidation of typical hydroxyl radical scavengers. Hydroxyl Radical 180-196 cytochrome p450 oxidoreductase Rattus norvegicus 119-145 6296101-13 1983 The results demonstrated that NADPH-cytochrome P-450 reductase may represent an important locus of oxygen activation leading to the production of a highly oxidizing species characteristic of the hydroxyl radical. Hydroxyl Radical 195-211 cytochrome p450 oxidoreductase Rattus norvegicus 30-62 6314373-1 1983 The oxidation of ethanol and typical hydroxyl radical scavengers by NADPH-cytochrome P-450 reductase and cytochrome P-450 purified from phenobarbital-treated rats were studied. Hydroxyl Radical 37-53 cytochrome p450 oxidoreductase Rattus norvegicus 68-100 6301443-0 1983 Leukotriene B4, C4, D4 and E4 inactivation by hydroxyl radicals. Hydroxyl Radical 46-63 complement C4A (Rodgers blood group) Homo sapiens 0-18 6303949-2 1983 The reaction is inhibitable to more than 90% by superoxide dismutase (SOD) - final concentration 200 micrograms/ml -, to about 60% by catalase - final concentration 10 mg/ml - and to 30% by the hydroxyl radical scavenger D-mannit - final concentration 100 mM. Hydroxyl Radical 194-210 superoxide dismutase 1 Homo sapiens 48-68 6303949-2 1983 The reaction is inhibitable to more than 90% by superoxide dismutase (SOD) - final concentration 200 micrograms/ml -, to about 60% by catalase - final concentration 10 mg/ml - and to 30% by the hydroxyl radical scavenger D-mannit - final concentration 100 mM. Hydroxyl Radical 194-210 superoxide dismutase 1 Homo sapiens 70-73 6314373-1 1983 The oxidation of ethanol and typical hydroxyl radical scavengers by NADPH-cytochrome P-450 reductase and cytochrome P-450 purified from phenobarbital-treated rats were studied. Hydroxyl Radical 37-53 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 74-90 6314373-10 1983 One pathway involves hydroxyl radicals which can be generated by the reductase, whereas the other pathway requires the combined presence of both the reductase and cytochrome P-450, and appears to be independent of oxygen radicals. Hydroxyl Radical 21-38 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 163-179 6286728-10 1982 Neutrophil-dependent chloramine generation was inhibited by catalase, the myeloperoxidase inhibitors, azide, cyanide, or aminotriazole and by chloride-free conditions, but not by superoxide dismutase or hydroxyl radical scavengers. Hydroxyl Radical 203-219 catalase Homo sapiens 60-68 6301163-0 1982 On the significance of the cytochrome P-450-dependent hydroxyl radical-mediated oxygenation mechanism. Hydroxyl Radical 54-70 cytochrome P-450 Oryctolagus cuniculus 27-43 6301163-6 1982 Administration of ethanol or benzene to rabbits, compounds known to be oxygenated by the hydroxyl radical-dependent mechanism, resulted in induction of a species of cytochrome P-450 effective in the radical-dependent metabolism of both chemicals. Hydroxyl Radical 89-105 cytochrome P-450 Oryctolagus cuniculus 165-181 6301163-10 1982 It is suggested that, for certain substrates, hydroxyl radical-mediated cytochrome P-450-dependent oxygenation reactions are of importance for the microsomal metabolism of these compounds. Hydroxyl Radical 46-62 cytochrome P-450 Oryctolagus cuniculus 72-88 6301163-12 1982 It is speculated that radical-producing species of cytochrome P-450 may contribute to hydroxyl radical-mediated cell damage. Hydroxyl Radical 86-102 cytochrome P-450 Oryctolagus cuniculus 51-67 6295407-0 1982 Generation of hydroxyl radical by anticancer quinone drugs, carbazilquinone, mitomycin C, aclacinomycin A and adriamycin, in the presence of NADPH-cytochrome P-450 reductase. Hydroxyl Radical 14-30 cytochrome p450 oxidoreductase Homo sapiens 141-173 6285925-0 1982 Aniline is hydroxylated by the cytochrome P-450-dependent hydroxyl radical-mediated oxygenation mechanism. Hydroxyl Radical 58-74 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 31-47 6290412-0 1982 Spin-trapping studies of hydroxyl radical addition to cytosine and 2"-deoxycytidine. Hydroxyl Radical 25-41 spindlin 1 Homo sapiens 0-4 6280774-0 1982 Enhanced production of hydroxyl radicals by the xanthine-xanthine oxidase reaction in the presence of lactoferrin. Hydroxyl Radical 23-40 lactotransferrin Sus scrofa 102-113 6277918-6 1982 Methemoglobin of hydroxyl radical or hypochlorous acid scavengers. Hydroxyl Radical 17-33 hemoglobin subunit gamma 2 Homo sapiens 0-13 6282074-17 1982 Although our data suggests the production of superoxide anion and hydroxyl radical from the MPO-H2O2-Cl- reaction, the actual presence or involvement of these free radical species is not confirmed herein. Hydroxyl Radical 66-82 myeloperoxidase Homo sapiens 92-95 6280774-4 1982 Hydroxyl radical production, measured by EPR spin trapping and by ethylene production from alpha-keto-gamma-methiol butyric acid, has been demonstrated to be produced by a Fenton-type Haber-Weiss reaction catalysed by lactoferrin. Hydroxyl Radical 0-16 lactotransferrin Sus scrofa 218-229 6776205-5 1980 In addition this inactivation of tyrosinase by dopa was not inhibited by any of: 1.4-diazabicyclo[2.2.2]octane, scavenger for singlet oxygen; D-mannitol, that for hydroxyl radical; superoxide dismutase, that for superoxide anion; and catalase, cleavaging enzyme for hydrogen peroxide. Hydroxyl Radical 163-179 tyrosinase Mus musculus 33-43 6280725-5 1982 In the absence of the catalase inhibitor azide, methanol may be oxidized primarily by the peroxidatic activity of catalase since there was little effect on methanol oxidation by competing hydroxyl radical scavengers. Hydroxyl Radical 188-204 catalase Rattus norvegicus 114-122 6280725-7 1982 The azide-insensitive (catalase-independent) pathway of methanol oxidation was inhibited by scavengers of hydroxyl radicals. Hydroxyl Radical 106-123 catalase Rattus norvegicus 23-31 6280725-11 1982 The stimulation by iron-EDTA was blocked by the competing hydroxyl radical scavengers even in the absence of azide, suggesting that the added iron-EDTA favorably with microsomal catalase for H2O2 to produce hydroxyl radicals (or a species with the oxidizing power of the hydroxyl radical). Hydroxyl Radical 58-74 catalase Rattus norvegicus 178-186 6280725-11 1982 The stimulation by iron-EDTA was blocked by the competing hydroxyl radical scavengers even in the absence of azide, suggesting that the added iron-EDTA favorably with microsomal catalase for H2O2 to produce hydroxyl radicals (or a species with the oxidizing power of the hydroxyl radical). Hydroxyl Radical 207-224 catalase Rattus norvegicus 178-186 6280725-11 1982 The stimulation by iron-EDTA was blocked by the competing hydroxyl radical scavengers even in the absence of azide, suggesting that the added iron-EDTA favorably with microsomal catalase for H2O2 to produce hydroxyl radicals (or a species with the oxidizing power of the hydroxyl radical). Hydroxyl Radical 207-223 catalase Rattus norvegicus 178-186 7342976-5 1981 GSH, FeSO4 and luminol was inhibited by catalase, superoxide dismutase, scavengers of hydroxyl radicals (sodium benzoate, n-butanol, D-mannitol, dimethyl sulphoxide) or metal-ion chelators (EDTA, diethylenetriaminepenta-acetic acid, diethyldithiocarbamate. Hydroxyl Radical 86-103 catalase Homo sapiens 40-48 6787051-5 1981 Externally added hydrogen peroxide markedly stimulated cytochrome P-450-dependent ethanol oxidation, but not until the concentration of H2O2 reached 0.3 mM, whereas the hydroxyl radical scavenger mannitol completely inhibited the cytochrome P-450-dependent acetaldehyde production. Hydroxyl Radical 169-185 cytochrome P-450 Oryctolagus cuniculus 230-246 7256355-2 1981 Both the protonated diethylamino and phenolic hydroxyl functions of amodiaquine are necessary for interaction with AChE. Hydroxyl Radical 46-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 7256355-3 1981 This suggests that the inhibition of AChE by amodiaquine may involve binding of the protonated diethylamino and phenolic hydroxyl functions to the anionic and esteric sites of the enzyme respectively. Hydroxyl Radical 121-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 6971825-1 1981 The trichloromethyl peroxy radical Cl3COO reacts with tryptophan, tryptophanyl-tyrosine and with lysozyme to form products whose overall absorption spectrum is different from those observed following the reaction of hydroxyl, bromide, thiocyanate or azide radicals. Hydroxyl Radical 216-224 adhesion G protein-coupled receptor L3 Homo sapiens 35-38 6971825-1 1981 The trichloromethyl peroxy radical Cl3COO reacts with tryptophan, tryptophanyl-tyrosine and with lysozyme to form products whose overall absorption spectrum is different from those observed following the reaction of hydroxyl, bromide, thiocyanate or azide radicals. Hydroxyl Radical 216-224 lysozyme Homo sapiens 97-105 7193215-6 1980 Catalase, cytochrome C, histidine, and methionine inhibited the PMA-induced 51Cr-release by human neutrophils, whereas superoxide dismutase, myeloperoxidase inhibitors, and some hydroxyl radical scavengers or singlet oxygen quenchers had no effect. Hydroxyl Radical 178-194 catalase Homo sapiens 0-8 7028115-16 1981 A hydroxyl in the manno configuration at C-2 interferes with transport as D-talose (Ki = 35.4 mM) has a lower affinity than D-galactose. Hydroxyl Radical 2-10 complement C2 Rattus norvegicus 41-44 6773547-6 1980 The stimulation by Fe-EDTA appears to represent a pathway involving hydroxyl radicals rather than catalase because (1) stimulation occurred in the presence of azide, which inhibits catalase, (2) stimulation occurred in the presence of 1-butanol, which is not an effective substrate for catalase, and (3) stimulation was blocked by hydroxyl radical scavenging agents, which do not affect catalase-mediated oxidation of ethanol. Hydroxyl Radical 68-85 catalase Homo sapiens 181-189 7429608-6 1980 Negative results obtained with scavengers of hydroxyl radicals and singlet molecular oxygen suggest that protection of superoxide dismutase by catalase from inactivation by hydrogen peroxide, is a likely explanation for the observed potentiation. Hydroxyl Radical 45-62 catalase Rattus norvegicus 143-151 6773547-6 1980 The stimulation by Fe-EDTA appears to represent a pathway involving hydroxyl radicals rather than catalase because (1) stimulation occurred in the presence of azide, which inhibits catalase, (2) stimulation occurred in the presence of 1-butanol, which is not an effective substrate for catalase, and (3) stimulation was blocked by hydroxyl radical scavenging agents, which do not affect catalase-mediated oxidation of ethanol. Hydroxyl Radical 68-85 catalase Homo sapiens 181-189 6773547-6 1980 The stimulation by Fe-EDTA appears to represent a pathway involving hydroxyl radicals rather than catalase because (1) stimulation occurred in the presence of azide, which inhibits catalase, (2) stimulation occurred in the presence of 1-butanol, which is not an effective substrate for catalase, and (3) stimulation was blocked by hydroxyl radical scavenging agents, which do not affect catalase-mediated oxidation of ethanol. Hydroxyl Radical 68-85 catalase Homo sapiens 181-189 6773547-6 1980 The stimulation by Fe-EDTA appears to represent a pathway involving hydroxyl radicals rather than catalase because (1) stimulation occurred in the presence of azide, which inhibits catalase, (2) stimulation occurred in the presence of 1-butanol, which is not an effective substrate for catalase, and (3) stimulation was blocked by hydroxyl radical scavenging agents, which do not affect catalase-mediated oxidation of ethanol. Hydroxyl Radical 68-84 catalase Homo sapiens 181-189 6773547-6 1980 The stimulation by Fe-EDTA appears to represent a pathway involving hydroxyl radicals rather than catalase because (1) stimulation occurred in the presence of azide, which inhibits catalase, (2) stimulation occurred in the presence of 1-butanol, which is not an effective substrate for catalase, and (3) stimulation was blocked by hydroxyl radical scavenging agents, which do not affect catalase-mediated oxidation of ethanol. Hydroxyl Radical 68-84 catalase Homo sapiens 181-189 6773547-6 1980 The stimulation by Fe-EDTA appears to represent a pathway involving hydroxyl radicals rather than catalase because (1) stimulation occurred in the presence of azide, which inhibits catalase, (2) stimulation occurred in the presence of 1-butanol, which is not an effective substrate for catalase, and (3) stimulation was blocked by hydroxyl radical scavenging agents, which do not affect catalase-mediated oxidation of ethanol. Hydroxyl Radical 68-84 catalase Homo sapiens 181-189 212265-3 1978 It was also shown that the above biochemical triad (1) involved an enzymatic step; (2) was enhanced by acidic pH (0.5) and Mg++; (3) was inhibited by Cu++ or low concentration of Mn++; (4) was dependent on H2O2, perhydroxyl radical (HO2) and hydroxyl radical (HO) since either catalase or superoxide dismutase or scavengers of HO2 or HO were inhibitor, and (5) involved multistep reactions. Hydroxyl Radical 215-231 catalase Homo sapiens 277-285 32915-0 1979 Participation of superoxide, hydrogen peroxide and hydroxyl radicals in NADPH-cytochrome P-450 reductase-catalyzed peroxidation of methyl linolenate. Hydroxyl Radical 51-68 cytochrome p450 oxidoreductase Homo sapiens 72-104 669142-2 1978 Hydroxyl derivatives were silylated and all chemicals were applied to columns of OV-1 and Dexsil-300 at a constant temperature of 260 degrees and 290 degrees, respectively. Hydroxyl Radical 0-8 protein tyrosine phosphatase 4A2 Homo sapiens 81-100 6244786-0 1980 Spin trapping of superoxide and hydroxyl radical: practical aspects. Hydroxyl Radical 32-48 spindlin 1 Homo sapiens 0-4 222335-0 1979 Reduction of ferricytochrome c, methemoglobin and metmyoglobin by hydroxyl and alcohol radicals. Hydroxyl Radical 66-74 hemoglobin subunit gamma 2 Homo sapiens 32-45 213032-0 1978 Spin-trapping studies of hydroxyl radical production involved in lipid peroxidation. Hydroxyl Radical 25-41 spindlin 1 Homo sapiens 0-4 212265-3 1978 It was also shown that the above biochemical triad (1) involved an enzymatic step; (2) was enhanced by acidic pH (0.5) and Mg++; (3) was inhibited by Cu++ or low concentration of Mn++; (4) was dependent on H2O2, perhydroxyl radical (HO2) and hydroxyl radical (HO) since either catalase or superoxide dismutase or scavengers of HO2 or HO were inhibitor, and (5) involved multistep reactions. Hydroxyl Radical 233-235 catalase Homo sapiens 277-285 212265-3 1978 It was also shown that the above biochemical triad (1) involved an enzymatic step; (2) was enhanced by acidic pH (0.5) and Mg++; (3) was inhibited by Cu++ or low concentration of Mn++; (4) was dependent on H2O2, perhydroxyl radical (HO2) and hydroxyl radical (HO) since either catalase or superoxide dismutase or scavengers of HO2 or HO were inhibitor, and (5) involved multistep reactions. Hydroxyl Radical 260-262 catalase Homo sapiens 277-285 176035-9 1976 The rate of acetylation of the dicholine compounds by ChAc parallels their activity in blocking neuromuscular transmission and it is suggested that other quaternary ammonium compounds containing hydroxyl or hydroxyethyl groupings may be acetylated by ChAc and this may affect their blocking action at the neuromuscular junction. Hydroxyl Radical 195-203 choline O-acetyltransferase Rattus norvegicus 54-58 1260505-3 1976 However similar complete inhibition of DNA strand breakage by catalase (EC 1.11.1.6) indicates that the hydroxyl radical (formed by interaction of superoxide with hydrogen peroxide) is the primary reactive species. Hydroxyl Radical 104-120 catalase Homo sapiens 62-70 1191713-5 1975 Reactions of the hydroxyl radical with DNA-bound proflavine also lead to a rate constant of about 2 - 10(9) M-1 - s-1. Hydroxyl Radical 17-33 myoregulin Homo sapiens 108-111 4722437-2 1973 Derivatives in which a hydroxyl group in the d-gluco configuration was inverted, or replaced by a hydrogen atom, at C-1, C-2, C-3, C-4 or C-6 of the d-glucose molecule, all bound to the carrier, confirming that no single hydroxyl group is essential for binding to the carrier. Hydroxyl Radical 23-31 complement C4A (Rodgers blood group) Homo sapiens 131-134 1184752-4 1975 The hydroxyl radical may be scavenged by mannitol, or its formation can be prevented by the addition of superoxide dismutase or catalase to the medium, thereby eliminating the premature death of the cells. Hydroxyl Radical 4-20 catalase Homo sapiens 128-136 1081087-5 1975 The hydroxyl radical reactivities of nucleotides, coenzymes, sugar phosphates and phospholipid components are all high (1-10 X 10(9) M-1 sec-1), indicating the importance of hydroxyl radical attack in the inactivation of these components in living cells, although not necessarily by dephosphorylation. Hydroxyl Radical 4-20 secretory blood group 1, pseudogene Homo sapiens 137-142 1081087-5 1975 The hydroxyl radical reactivities of nucleotides, coenzymes, sugar phosphates and phospholipid components are all high (1-10 X 10(9) M-1 sec-1), indicating the importance of hydroxyl radical attack in the inactivation of these components in living cells, although not necessarily by dephosphorylation. Hydroxyl Radical 174-190 secretory blood group 1, pseudogene Homo sapiens 137-142 164901-7 1975 This distance decreases to 6.9 A when NADH is bound, and a Co(II) to methyne proton distance of 6.6 A is determined indicating a conformation change leading to the formation of a second sphere enzyme-Co(II)-isobutyramide complex in which a hydroxyl or water ligand intervenes between the metal and the substrate analog. Hydroxyl Radical 240-248 mitochondrially encoded cytochrome c oxidase II Homo sapiens 59-64 164901-7 1975 This distance decreases to 6.9 A when NADH is bound, and a Co(II) to methyne proton distance of 6.6 A is determined indicating a conformation change leading to the formation of a second sphere enzyme-Co(II)-isobutyramide complex in which a hydroxyl or water ligand intervenes between the metal and the substrate analog. Hydroxyl Radical 240-248 mitochondrially encoded cytochrome c oxidase II Homo sapiens 59-65 164901-10 1975 The role of the catalytic Co(II) thus appears to be the activation of a hydroxyl or water ligand which polarizes the aldehyde carbonyl group by hydrogen bonding. Hydroxyl Radical 72-80 mitochondrially encoded cytochrome c oxidase II Homo sapiens 26-32 4857420-9 1974 Catalase and benzoate inhibited the chemiluminescence of phagocytosis to a slight extent, suggesting that hydrogen peroxide and hydroxyl radical, respectively, might also be involved in this phenomenon. Hydroxyl Radical 128-144 catalase Homo sapiens 0-8 4722437-2 1973 Derivatives in which a hydroxyl group in the d-gluco configuration was inverted, or replaced by a hydrogen atom, at C-1, C-2, C-3, C-4 or C-6 of the d-glucose molecule, all bound to the carrier, confirming that no single hydroxyl group is essential for binding to the carrier. Hydroxyl Radical 23-31 complement C6 Homo sapiens 138-141 17847246-1 1971 The electrostatic energy of the 2M(1) muscovite structure, KAl(2)(Si(3)Al)- O(10)(OH)(2), has been calculated as a function of the orientation of the hydroxyl group (O-H distance = 0.97 angstrom). Hydroxyl Radical 150-158 fibroblast growth factor receptor 1 Homo sapiens 59-64 4502123-0 1972 [Long term experiences with the galvanic pin element for long time hydroxyl-copper-depot ionophoresis]. Hydroxyl Radical 67-75 dynein light chain LC8-type 1 Homo sapiens 41-44 13525671-6 1958 The conductance change is regarded as an essential property of rhodopsin, because it occurs in aqueous suspension as well as in digitonin solution; it may be caused by hydrogen or hydroxyl ions and some other conductive substances. Hydroxyl Radical 180-188 rhodopsin Homo sapiens 63-72 5275374-1 1970 Treatment of deoxycorticosterone with reagents that abstract a hydrogen atom from the C-21-hydroxyl group leads to the formation of androsta-4,16-dien-3-one. Hydroxyl Radical 91-99 TBL1X/Y related 1 Homo sapiens 86-90 5230258-0 1967 [The galvanic pin element for prolonged hydroxyl-copper-depot iontophoresis according to Knappwost in theory and practice]. Hydroxyl Radical 40-48 dynein light chain LC8-type 1 Homo sapiens 14-17 19872729-1 1933 The potentiometric method was applied to the study of the influence of cyanide and of hydroxyl ion on methemoglobin. Hydroxyl Radical 86-94 hemoglobin subunit gamma 2 Homo sapiens 102-115 33910746-2 2021 The presence of active sites such as hydroxyl, carbonyl, thioethers, and amines, gave the membranes high adsorption capacities for the metal ions Au (III), Co (II), and Fe (III), as well as the cationic organic dye methylene blue (MB). Hydroxyl Radical 37-45 mitochondrially encoded cytochrome c oxidase II Homo sapiens 156-163 33652222-4 2021 The epoxides are unstable and the C-O bond cleavage easily occurs by the reaction with hydronium ion or hydroxyl radicals, yielding endocrine disruptor hydroxylated DDT. Hydroxyl Radical 104-121 D-dopachrome tautomerase Homo sapiens 165-168 33744841-0 2021 Hydroxyl radical induced structural perturbations make insulin highly immunogenic and generate an auto-immune response in type 2 diabetes mellitus. Hydroxyl Radical 0-16 insulin Homo sapiens 55-62 33744841-2 2021 This study characterizes the hydroxyl radical (OH) modifications of insulin, evaluates its cytotoxicity and immunogenicity, and probes its role in type 2 diabetes (T2DM) autoimmunity. Hydroxyl Radical 29-45 insulin Homo sapiens 68-75 33636666-6 2021 The reaction mechanisms of AAP with hydroxyl radical (HO ), reactive chlorine species (RCS), and reactive nitrogen species (RNS) were discussed in detail. Hydroxyl Radical 36-52 serpin family F member 2 Homo sapiens 27-30 33578158-7 2021 The potential for hydroxyl radical generation was measured to be 1.8 V at pH = 12 and 2.6 V at pH = 2.The catalytic degradation rate of methylene blue (MB) follows pseudo first order reaction kinetics, and the reaction constant K value reached 0.02964 -k/min-1, twice as much as that obtained from electrodeposition electrode (Ti/Cu/SnO2-SbOX). Hydroxyl Radical 18-34 strawberry notch homolog 1 Homo sapiens 333-336 33881052-3 2021 GOx on the surface of hollow mesoporous silica nanoparticles can catalyze the decomposition of intratumoral glucose to generate gluconic acid and H2O2, while Fe3O4 nanoparticles as a Fenton reaction catalyst can in situ catalyze H2O2 to produce highly toxic hydroxyl radicals ( OH). Hydroxyl Radical 258-275 hydroxyacid oxidase 1 Homo sapiens 0-3 33960373-2 2021 They can then spontaneously decompose to truncated oxidised phospholipids composed of aldehyde, carboxyl and hydroxyl species of five to nine carbon atoms chain length, many of which exhibit potent biological activities. Hydroxyl Radical 109-117 tryptophan 2,3-dioxygenase Homo sapiens 38-40 33960373-2 2021 They can then spontaneously decompose to truncated oxidised phospholipids composed of aldehyde, carboxyl and hydroxyl species of five to nine carbon atoms chain length, many of which exhibit potent biological activities. Hydroxyl Radical 109-117 tryptophan 2,3-dioxygenase Homo sapiens 134-136 33882668-3 2021 Among all catalysts examined, Co(II) exhibits the highest reactivity for the activation of PMS, following the conventional Fenton-like mechanism, in which free radicals (i.e., sulfate radicals and hydroxyl radicals) are reckoned as the reactive species. Hydroxyl Radical 197-214 mitochondrially encoded cytochrome c oxidase II Homo sapiens 30-36 33923136-6 2021 CeO2NPs have been reported to act as a ROS and reactive nitrogen species (RNS) scavenger and to have multi-enzyme mimetic activity, including SOD activity (deprotionation of superoxide anion into oxygen and hydrogen peroxide), catalase activity (conversion of hydrogen peroxide into oxygen and water), and peroxidase activity (reducing hydrogen peroxide into hydroxyl radicals). Hydroxyl Radical 359-376 superoxide dismutase 1 Homo sapiens 142-145 33636666-6 2021 The reaction mechanisms of AAP with hydroxyl radical (HO ), reactive chlorine species (RCS), and reactive nitrogen species (RNS) were discussed in detail. Hydroxyl Radical 54-56 serpin family F member 2 Homo sapiens 27-30 33636666-9 2021 Based on the mechanism analysis, the second-order rate constants of AAP reacts with HO , Cl , NH2, ClO , Cl2 - and NO2 were calculated through transition state theory as 2.66x109 M-1 s-1, 2.61x109 M-1 s-1, 1.02x107 M-1 s-1, 7.74x106 M-1 s-1, 1.32x106 M-1 s-1, 1.48x103 M-1 s-1 respectively. Hydroxyl Radical 84-86 serpin family F member 2 Homo sapiens 68-71 33636666-9 2021 Based on the mechanism analysis, the second-order rate constants of AAP reacts with HO , Cl , NH2, ClO , Cl2 - and NO2 were calculated through transition state theory as 2.66x109 M-1 s-1, 2.61x109 M-1 s-1, 1.02x107 M-1 s-1, 7.74x106 M-1 s-1, 1.32x106 M-1 s-1, 1.48x103 M-1 s-1 respectively. Hydroxyl Radical 84-86 endogenous retrovirus group W member 5 Homo sapiens 106-109 33755889-8 2021 Assays with radical scavenging experiments confirmed that MgO/EG-mediated oxidation was dependent on a hydroxyl radical pathway. Hydroxyl Radical 103-119 podocalyxin like 2 Homo sapiens 62-64 33440293-3 2021 In the present study, we show that the biological oxidant hypochlorite promotes the formation of soluble high molecular weight fibrinogen assemblies >=40 x 106 Da, that do not accumulate when fibrinogen is induced to aggregate by other stresses such as heating or hydroxyl-mediated damage in vitro. Hydroxyl Radical 264-272 fibrinogen beta chain Homo sapiens 127-137 33360171-5 2021 Quenching experiments and EPR results showed that sulfate radical (SO4 -) and hydroxyl radical ( OH) were the dominant oxidants in inducing the oxidative dissolution of Ag2S-NPs. Hydroxyl Radical 78-94 angiotensin II receptor type 1 Homo sapiens 169-173 33337576-1 2021 The difluoromethyl (CHF 2 ) group has attracted significant attention in drug discovery and development efforts, owing to its ability to serve as fluorinated bioisostere of methyl, hydroxyl, and thiol groups. Hydroxyl Radical 181-189 hes related family bHLH transcription factor with YRPW motif 1 Homo sapiens 20-25 33325928-5 2021 Hydroxyl radicals ( OH) were produced for chemodynamic therapy (CDT) employing the Fe2+-driven Fenton reaction, which could be greatly promoted by Fe3+-involved glutathione (GSH) depletion and GOx-catalyzed acidity recovery and H2O2 self-sufficiency. Hydroxyl Radical 0-17 hydroxyacid oxidase 1 Homo sapiens 193-196 33464716-4 2021 FePc/HNCSs simultaneously exhibit peroxidase (POD)- and catalase (CAT)-like activities, which not only can convert endogenous hydrogen peroxide (H2 O2 ) into highly toxic hydroxyl radicals ( OH) for catalytic therapy, but also decompose H2 O2 to oxygen (O2 ) to enhance O2 -dependent PDT. Hydroxyl Radical 171-188 catalase Homo sapiens 66-69 33293086-7 2021 According to the analysis, hydroxyl groups and amine groups participated in the chemical reaction of Co(II) and Ni(II) removal, and cation-exchange chemical adsorption was dominant during the Co(II)- and Ni(II)-removal process. Hydroxyl Radical 27-35 mitochondrially encoded cytochrome c oxidase II Homo sapiens 101-107 33321618-3 2021 The modified beta-CD was grafted with Graphene oxide (GO), and the resulting platform gain many functional groups, including the hydroxyl (-OH), carboxylic acid (-COOH), and amine functional groups (-NH2). Hydroxyl Radical 129-137 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 13-20 33546740-6 2021 Similarly, assays of antioxidant activity disclosed that THP had reasonable concentration-dependent hydroxyl radical and superoxide radical scavenging activities, peroxidation inhibition ability and ferrous ion chelating potency, in addition to a significant 1,1-diphenyl-2-picrylhydrazyl radical scavenging capacity. Hydroxyl Radical 100-116 uromodulin Mus musculus 57-60 33219494-7 2021 The modified Imeglimin, especially in the structure of hydrophilic hydroxyl or piperidine rings, could improve the activity of the compound to promote insulin secretion. Hydroxyl Radical 67-75 insulin Mesocricetus auratus 151-158 32814135-5 2021 Based on the characterization results, the sulfate radicals and hydroxyl radicals were considered to be the main free radicals which were involved into the circulation of Co(II)-Co(III)-Co(II) as well as the oxidation of Fe(II), which was responsible for the remarkable catalytic efficiency. Hydroxyl Radical 64-81 mitochondrially encoded cytochrome c oxidase II Homo sapiens 171-177 33617491-2 2021 The exploration in the electrocatalytic process revealed that the main intermediate active oxidation products were Co(III), accompanied with hydroxyl radicals and peroxodiphosphates (P2O84-). Hydroxyl Radical 141-158 mitochondrially encoded cytochrome c oxidase III Homo sapiens 115-122 32814135-5 2021 Based on the characterization results, the sulfate radicals and hydroxyl radicals were considered to be the main free radicals which were involved into the circulation of Co(II)-Co(III)-Co(II) as well as the oxidation of Fe(II), which was responsible for the remarkable catalytic efficiency. Hydroxyl Radical 64-81 mitochondrially encoded cytochrome c oxidase II Homo sapiens 186-192 32841880-9 2021 It is estimated that 1O2 and hydroxyl radicals ( OH) contributed ~65.2% and ~24.2% to TC degradation in the Fe3O4-NCS-2/PMS system, respectively. Hydroxyl Radical 29-46 cytosolic thiouridylase subunit 2 Homo sapiens 114-119 31760822-2 2020 The BF framework aims to endow the conjugate molecules with ability for inhibition of AChE (bimodal way) and of amyloid-beta peptide aggregation, besides providing metal (Fe, Cu) chelating ability and concomitant extra anti-oxidant activity, for the hybrids with hydroxyl substitution. Hydroxyl Radical 263-271 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 32857354-1 2021 Spin trapping with cyclic nitrones coupled to electron paramagnetic resonance (EPR) enables the detection and characterization of oxygen-derived free radicals, such as superoxide and hydroxyl radicals, in living cells. Hydroxyl Radical 183-200 spindlin 1 Homo sapiens 0-4 33211784-4 2020 syn-MVK-oxide undergoes intramolecular 1,4 H-atom transfer to form a substituted vinyl hydroperoxide intermediate, 2-hydroperoxybuta-1,3-diene (HPBD), which subsequently decomposes to hydroxyl and vinoxylic radical products. Hydroxyl Radical 184-192 mevalonate kinase Homo sapiens 4-7 33084194-7 2020 LAP displayed a strong antioxidant activity at low concentrations evaluated by the 2,2-diphenyl-1-picrylhydrazyl (DPPH)-radical scavenging, ferric reducing activity power (FRAP), free radical scavenging ability, superoxide radical-scavenging and hydroxyl radical-scavenging abilities. Hydroxyl Radical 246-262 LAP Homo sapiens 0-3 33179626-3 2020 Based on a non cell-permeable PtdIns(3,5)P2 inhibitor of ASM, we developed a compound with o-nitrobenzyl photocages and butyryl esters to transiently mask hydroxyl groups. Hydroxyl Radical 155-163 sphingomyelin phosphodiesterase 1 Homo sapiens 57-60 33405317-6 2020 Interestingly, in vitro treatment with VIP restored mitochondrial functions and its efficacy was equal to super oxide dismutase and dimethyl sulfoxide, indicating involvement of superoxide free radical (O2 -) and hydroxyl radical ( OH) in progression of UC. Hydroxyl Radical 214-230 vasoactive intestinal polypeptide Mus musculus 39-42 32693277-2 2020 These phenolic compounds are removed from tap water using horseradish roots (Raphanus sativus) that contain peroxidase as catalyst and H2O2 to generate hydroxyl radicals. Hydroxyl Radical 152-169 peroxidase E5-like Raphanus sativus 108-118 33064470-0 2020 First Direct and Unequivocal Electron Spin Resonance Spin-Trapping Evidence for pH-Dependent Production of Hydroxyl Radicals from Sulfate Radicals. Hydroxyl Radical 107-124 spindlin 1 Homo sapiens 38-42 33064938-0 2020 Imaging of Hydroxyl-Radical Generation Using Dynamic Nuclear Polarization-Magnetic Resonance Imaging and a Spin-Trapping Agent. Hydroxyl Radical 11-27 spindlin 1 Homo sapiens 107-111 33064938-5 2020 In this study, we investigated the visualization of hydroxyl radicals generated from the Fenton reaction by combining DNP-MRI with a spin-trapping agent (DMPO: 5,5-dimethyl-1-pyrroline N-oxide) for OH. Hydroxyl Radical 52-69 spindlin 1 Homo sapiens 133-137 33064470-0 2020 First Direct and Unequivocal Electron Spin Resonance Spin-Trapping Evidence for pH-Dependent Production of Hydroxyl Radicals from Sulfate Radicals. Hydroxyl Radical 107-124 spindlin 1 Homo sapiens 53-57 32829853-2 2020 Sulfate radicals (SO4-) and hydroxyl radicals (OH ) were generated through the activation of peroxymonosulfate (PMS) by Co/Fe bi-MOFs/CNF. Hydroxyl Radical 28-45 NPHS1 adhesion molecule, nephrin Homo sapiens 134-137 32621953-5 2020 Human carbonyl reductase 1 (CBR1) is one of the most effective human reductases for producing hydroxyl metabolites and thus may be involved in increasing the cardiotoxicity and decreasing the antineoplastic effect of anthracycline antibiotics. Hydroxyl Radical 94-102 carbonyl reductase 1 Homo sapiens 6-26 32567462-0 2020 Deletion of the lon gene augments expression of Salmonella Pathogenicity Island (SPI)-1 and metal ion uptake genes leading to the accumulation of bactericidal hydroxyl radicals and host pro-inflammatory cytokine-mediated rapid intracellular clearance. Hydroxyl Radical 159-176 lon peptidase 1, mitochondrial Mus musculus 16-19 32567462-4 2020 The lon mutant exhibited increased accumulation of hydroxyl (OH ) ions that lead to cell damage due to oxidative stress. Hydroxyl Radical 51-59 lon peptidase 1, mitochondrial Mus musculus 4-7 32621953-5 2020 Human carbonyl reductase 1 (CBR1) is one of the most effective human reductases for producing hydroxyl metabolites and thus may be involved in increasing the cardiotoxicity and decreasing the antineoplastic effect of anthracycline antibiotics. Hydroxyl Radical 94-102 carbonyl reductase 1 Homo sapiens 28-32 32931260-0 2020 Electron Spin Resonance Evidence for Electro-generated Hydroxyl Radicals. Hydroxyl Radical 55-72 spindlin 1 Homo sapiens 9-13 32812559-1 2020 The hydroxyl substituent in flavonoids can cause the binding site to change from DS1 to DS2 and restore the ESIPT process of flavonoids, thereby leading to a unique dual-emissive response towards human serum albumin. Hydroxyl Radical 4-12 albumin Homo sapiens 202-215 32883066-2 2020 Cu2+ dyshomeostasis and oxidative stress, such as hydroxyl radical ( OH), are found to be associated with peptide aggregations. Hydroxyl Radical 50-66 immunoglobulin kappa variable 1-35 Mus musculus 0-3 32902530-5 2020 In contrast, the electrochemical reduction under mild polarization conditions favored the formation of sp3 defects over vacancies, with a preferential removal of carbonyl and carboxyl groups over hydroxyl/epoxides. Hydroxyl Radical 196-204 Sp3 transcription factor Homo sapiens 103-106 33134558-3 2020 Here, we show high air emissions from VCP usage (>= 14 kg person-1 yr-1, at least 1.7x higher than current operational estimates) are supported by multiple estimation methods and constraints imposed by ambient levels of ozone, hydroxyl radical (OH) reactivity, and the organic component of fine particulate matter (PM2.5) in Pasadena, California. Hydroxyl Radical 227-243 valosin containing protein Homo sapiens 38-41 32402825-4 2020 Mica surfaces modified by functional groups of amine (NH2), hydroxyl (OH), or carboxyl (COOH) through self-assembled monolayers were used to investigate how chemical functionalities affect the Ca-As heterogeneous nucleation, in which the distributions of formation kinetics and size (as measured by the change in particle height) of nucleated Ca-As particles were measured by using in situ atomic force microscopy. Hydroxyl Radical 60-68 MHC class I polypeptide-related sequence A Homo sapiens 0-4 32346945-1 2020 Peroxidase mimicking nanozymes that can generate toxic hydroxyl radicals ( OH) hold great promise as antibacterial alternatives. Hydroxyl Radical 55-72 AT695_RS02070 Staphylococcus aureus 0-10 32967483-0 2020 Histidine-rich glycoprotein possesses anti-oxidant activity through self-oxidation and inhibition of hydroxyl radical production via chelating divalent metal ions in Fenton"s reaction. Hydroxyl Radical 101-117 histidine rich glycoprotein Homo sapiens 0-27 32967483-6 2020 Hydroxyl radical is known as the most important species among ROS in pathogenesis; however, the direct influence of HRG on hydroxyl radical formation and ROS activity is poorly understood. Hydroxyl Radical 123-139 histidine rich glycoprotein Homo sapiens 116-119 32967483-7 2020 In this study, we showed that HRG, in a concentration-dependent manner, efficiently inhibited the production of hydroxyl radical induced by the Fenton"s reaction through chelation of the divalent iron. Hydroxyl Radical 112-128 histidine rich glycoprotein Homo sapiens 30-33 32872578-0 2020 Indirect Photodegradation of Sulfamethoxazole and Trimethoprim by Hydroxyl Radicals in Aquatic Environment: Mechanisms, Transformation Products and Eco-Toxicity Evaluation. Hydroxyl Radical 66-83 ciliogenesis associated kinase 1 Homo sapiens 148-151 32247235-3 2020 The optimum ratio of Fe(II)/PS was 1:2, and the hydroxyl radical (HO) and sulfate radical (SO4-) generation rate were 5.56 mM h-1 and 8.62 muM h-1, respectively. Hydroxyl Radical 66-68 latexin Homo sapiens 139-142 32775745-3 2020 FTIR spectra shows compound functional groups of hydroxyl (- OH) at peak 1 (3449.92 cm-1), carboxyl (-COOH) at peak 2 (1719.42 cm-1) and peak 3 (1702.62 cm-1), and alcohol (C-OH) at peak 4 (1628.12 cm-1) and epoxy (CO) at peak 5 (1158.51 cm-1), which is similar to the GO synthesis from pure graphite. Hydroxyl Radical 49-57 pseudopodium enriched atypical kinase 1 Homo sapiens 68-74 32692926-6 2020 The major mechanism for these variations was the oxidation of sp3-C and butenyl group by hydroxyl radical and the hydrolysis of cyano group, which introduced the hydroxyl, carboxyl, and amide groups and rough topographies on the surface of ABS polymers. Hydroxyl Radical 89-105 Sp3 transcription factor Homo sapiens 62-65 31730966-6 2020 The main adsorption mechanism was the complexation between the carboxyl, amino, and hydroxyl groups in MCS-PAA and Pb(II). Hydroxyl Radical 84-92 submaxillary gland androgen regulated protein 3B Homo sapiens 115-121 32679885-4 2020 There are both more hydroxyl (-OH) and carboxyl (-COOH) functional groups on the surface of CLB compared to those from control (without H3PO4 impregnation), resulting in more ion exchanges and complexation reaction for CLB with Cu(II) and Pb(II). Hydroxyl Radical 20-28 citramalyl-CoA lyase Homo sapiens 92-95 32679885-4 2020 There are both more hydroxyl (-OH) and carboxyl (-COOH) functional groups on the surface of CLB compared to those from control (without H3PO4 impregnation), resulting in more ion exchanges and complexation reaction for CLB with Cu(II) and Pb(II). Hydroxyl Radical 20-28 citramalyl-CoA lyase Homo sapiens 219-222 32291646-7 2020 At pH>pHpzc, the main Pb(II) existing species of Pb(II) and Pb(OH)+ combine with the carboxyl, hydroxyl, and phosphate functional groups via electrostatic interactions and hydrogen bonding. Hydroxyl Radical 95-103 submaxillary gland androgen regulated protein 3B Homo sapiens 22-28 32291646-7 2020 At pH>pHpzc, the main Pb(II) existing species of Pb(II) and Pb(OH)+ combine with the carboxyl, hydroxyl, and phosphate functional groups via electrostatic interactions and hydrogen bonding. Hydroxyl Radical 95-103 submaxillary gland androgen regulated protein 3B Homo sapiens 49-55 32563474-2 2020 For SMD1, MgSi particles were densely assembled on the surface of SPS, assisted by complexation between Fe3+ and hydroxyl phenol. Hydroxyl Radical 113-121 small nuclear ribonucleoprotein D1 polypeptide Homo sapiens 4-8 31820846-4 2020 The appearance of the FTIR absorption peaks in between at 516-1031 and 3,636 cm-1 shows phosphate and hydroxyl groups in prepared HAp, respectively. Hydroxyl Radical 102-110 reticulon 3 Homo sapiens 130-133 32714406-13 2020 The 6"-hydroxyl and 6""-hydroxyl on the 3-glycosyl of ginsenoside Rg3 are prone to form hydrogen bonds (Lys151 and Lys221) with the active sites of EpCAM ligand binding domain. Hydroxyl Radical 6-15 epithelial cell adhesion molecule Homo sapiens 148-153 31468655-5 2020 The CuTA nanozyme exhibits intrinsic superoxide dismutase-like activity, catalase-like activity, and hydroxyl radical elimination capacity. Hydroxyl Radical 101-117 cutA divalent cation tolerance homolog Mus musculus 4-8 31672636-2 2020 The hydrolytic activity of MelA alpha-galactosidase on a wide range of p-nitrophenyl glycoside derivatives and carbohydrates of different molecular-weights showed its high selectivity and efficiency towards the alpha(1 6) glycosidic bonds involving the anomeric carbon of galactose and the C6-hydroxyl group of galactose or glucose units. Hydroxyl Radical 290-301 alpha-galactosidase Lactobacillus plantarum WCFS1 27-31 31672636-4 2020 The catalytic mechanism of MelA for the production of alpha-GOS was elucidated, revealing its great preference for the transfer of galactosyl residues to the C6-hydroxyl group of galactose units to elongate the chain of alpha-GOS having either a terminal sucrose (raffinose family oligosaccharides, RFOS) or a terminal glucose (melibiose, manninotriose and verbascotetraose). Hydroxyl Radical 158-169 alpha-galactosidase Lactobacillus plantarum WCFS1 27-31 32343290-3 2020 In the presence of PNK, the 3"-phosphate end of RS will be converted to the 3"-hydroxyl one, and then extended to a long poly-adenine (poly-A) sequence under the catalysis of terminal deoxynucleotidyl transferase (TdT). Hydroxyl Radical 78-87 polynucleotide kinase 3'-phosphatase Homo sapiens 19-22 32396322-8 2020 The superior ferroelectric polarization observed in this case highly favors the adsorption of electrically-charged species, in particular of the dye in the protonated form (Rh-beta+) and of OH-, to the catalyst surface and the production of hydroxyl radicals responsible for dye degradation. Hydroxyl Radical 241-258 DExH-box helicase 9 Homo sapiens 173-180 32343290-3 2020 In the presence of PNK, the 3"-phosphate end of RS will be converted to the 3"-hydroxyl one, and then extended to a long poly-adenine (poly-A) sequence under the catalysis of terminal deoxynucleotidyl transferase (TdT). Hydroxyl Radical 78-87 DNA nucleotidylexotransferase Homo sapiens 175-212 32343290-3 2020 In the presence of PNK, the 3"-phosphate end of RS will be converted to the 3"-hydroxyl one, and then extended to a long poly-adenine (poly-A) sequence under the catalysis of terminal deoxynucleotidyl transferase (TdT). Hydroxyl Radical 78-87 DNA nucleotidylexotransferase Homo sapiens 214-217 32337977-3 2020 We show that hydroxyl radicals generated by ionizing radiation can be used to etch gold nanorods (AuNRs) and silver nanoprisms (AgNPRs), yielding reproducible color changes for radiation dose detection in the range of 50-2000 Rad, broad enough to cover doses used in hyperfractionated, conventional, and hypofractionated radiotherapy. Hydroxyl Radical 13-30 RRAD, Ras related glycolysis inhibitor and calcium channel regulator Homo sapiens 226-229 32220586-11 2020 Naringenin, a flavanone analog with three hydroxyl moieties, could suppress IL-6 overexpression to baseline control. Hydroxyl Radical 42-50 interleukin 6 Mus musculus 76-80 32044711-7 2020 Due to this absence of ligand on the surface of CdS nanocrystals, a much enhanced MO degradation has been observed, as the e--h+ pair in the CdS and subsequent generation of free radicals such as hydroxyl, can efficiently oxidize the organic material MO and therefore, degrade this pollutant faster under visible light illumination. Hydroxyl Radical 196-204 CDP-diacylglycerol synthase 1 Homo sapiens 48-51 32483451-8 2020 At this time, the released ferrous ions from SOD-Fe0 and H2O2 are further transformed to highly toxic hydroxyl radicals ( OH) for specifically killing tumor cells, and there was no obvious toxicological response during long-term treatment. Hydroxyl Radical 102-119 superoxide dismutase 1 Homo sapiens 45-52 31918320-5 2020 Besides, geometric parameters, ESP, topology and NBO analysis proved that the ILs acidity on the hydroxyl-free surface was mainly influenced by the interaction between -SO3 group and cluster surface. Hydroxyl Radical 97-105 protein tyrosine phosphatase receptor type V, pseudogene Homo sapiens 31-34 32105995-6 2020 The results of the same test for the bovine serum albumin (BSA) indicated that the hydroxyl radical can mitigate the fouling of UF membranes by degrading the tertiary and secondary structures of BSA and partly oxidizing the side chain groups. Hydroxyl Radical 83-99 albumin Bos taurus 44-57 32195573-10 2020 Lastly, the two phenolic hydroxyl groups were critical for the compounds to bind LysRS. Hydroxyl Radical 25-33 lysyl-tRNA synthetase 1 Homo sapiens 81-86 31975003-3 2020 The results show that Fe3O4 nanoparticles can be well dispersed on NI/S flakes and the hydrolyzed APTES molecules can simultaneously bond to the hydroxyl groups of Fe3O4 and NI/S. Hydroxyl Radical 145-153 solute carrier family 5 member 5 Homo sapiens 174-178 31945692-4 2020 The mechanisms by which HK-2 protects cells is twofold, first by its ability to reduce oxidative stress generated by free radicals, and second, by its ability to complex biologically active transition metals such as Fe+2, thus reducing their availability to participate in the Fenton reaction where highly toxic hydroxyl radicals are generated. Hydroxyl Radical 312-320 hexokinase 2 Homo sapiens 24-28 31931569-4 2020 The presence of ALP converts phosphate groups into hydroxyl groups at DNA helix, weakening the coordination of DNA with UCNPs. Hydroxyl Radical 51-59 alkaline phosphatase, placental Homo sapiens 16-19 32044231-4 2020 Our SAR analysis indicated that removal of a hydroxyl group enhanced the STAT3 phosphorylation inhibitory activity. Hydroxyl Radical 45-53 signal transducer and activator of transcription 3 Homo sapiens 73-78 31880458-4 2020 The results demonstrate that the deprotonated hydroxyl group in the chromophore and the nitrogen atom ND1 in His148 are charged negatively and positively, respectively, forming an ion pair. Hydroxyl Radical 46-54 mitochondrially encoded NADH dehydrogenase 1 Homo sapiens 102-105 32054947-0 2020 Blockade of the renin-angiotensin system suppresses hydroxyl radical production in the rat striatum during carbon monoxide poisoning. Hydroxyl Radical 52-60 renin Rattus norvegicus 16-21 32033016-2 2020 The results of a molecular docking study showed that the oxygen atom in the five-membered ring of octenyl succinic anhydride (OSA) formed a strong hydrogen bond interaction (1.89 A) with the hydrogen atom in the hydroxyl group of C-6. Hydroxyl Radical 212-220 complement C6 Homo sapiens 230-233 31604191-7 2020 Monte Carlo simulation of delta18O-NO3- indicated that oxidation process by hydroxyl radical contributed 65 +- 14% of NO3-, with the rest from hydrolysis of N2O5. Hydroxyl Radical 76-84 NBL1, DAN family BMP antagonist Homo sapiens 35-38 31604191-7 2020 Monte Carlo simulation of delta18O-NO3- indicated that oxidation process by hydroxyl radical contributed 65 +- 14% of NO3-, with the rest from hydrolysis of N2O5. Hydroxyl Radical 76-84 NBL1, DAN family BMP antagonist Homo sapiens 118-121 31604191-8 2020 Wind speed had large effect on delta18O-NO3- variations in the atmosphere with more involvement of hydroxyl radical reactions when wind speed increased. Hydroxyl Radical 99-107 NBL1, DAN family BMP antagonist Homo sapiens 40-43 32036165-7 2020 Mechanistic approach indicated that TQ-4 inhibited the LPS-induced JNK phosphorylation, IkappaBalpha degradation, NF-kappaB p65 phosphorylation and its nuclear translocation, and hydroxyl radical (OH ) productions in RAW 264.7 cells. Hydroxyl Radical 179-187 toll-like receptor 4 Mus musculus 55-58 31968151-4 2020 Among this series of compounds 3m bearing one ethoxy and a hydroxyl group on the phenyl ring on 2,4,5-trisubstituted imidazoles proved potent AChE inhibitor (102.56+-0.14). Hydroxyl Radical 59-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 32274323-4 2020 The in vitro study using Huh7 cancer cells reveals that Fe2+ released from FeS@BSA nanoclusters induces the toxic hydroxyl radical ( OH) effectively via the Fenton reaction. Hydroxyl Radical 114-130 MIR7-3 host gene Homo sapiens 25-29 31942788-5 2020 The calculations of DFT, the experimental results and the characterization analyses suggest that the binding mechanisms are the chelation, ion exchange and electrostatic interactions between hydroxyl/amino/sulfhydryl groups of UiO-66-ATA(Zr) and Pb(II). Hydroxyl Radical 191-199 submaxillary gland androgen regulated protein 3B Homo sapiens 246-252 31906622-2 2020 The theoretically calculated spectra reproduced the experimentally observed spectra well, revealing that VUV-ECD exhibited unique spectra depending on the alpha-anomer and beta-anomer configurations of the hydroxyl group at C-1, and the three gauche (G) and trans (T) rotamer conformations (GT, GG, and TG) of the hydroxymethyl group at C-5. Hydroxyl Radical 206-214 heterogeneous nuclear ribonucleoprotein C Homo sapiens 224-227 31906622-3 2020 These unique spectra could be ascribed to differences in the patterns of intramolecular hydrogen bonds around the hydroxymethyl group at C-5 for the three rotamers and around the hydroxyl group at C-1 for the two anomers. Hydroxyl Radical 179-187 complement C5 Homo sapiens 137-140 31906622-3 2020 These unique spectra could be ascribed to differences in the patterns of intramolecular hydrogen bonds around the hydroxymethyl group at C-5 for the three rotamers and around the hydroxyl group at C-1 for the two anomers. Hydroxyl Radical 179-187 heterogeneous nuclear ribonucleoprotein C Homo sapiens 197-200 31912858-2 2020 The regioselectivity of the spiroketalization reaction is decisively influenced by the alpha or beta-orientation of the hydroxyl group at C-5. Hydroxyl Radical 120-128 complement C5 Homo sapiens 138-141 32025498-7 2020 ODG (15.625-250.00 mug mL-1) promoted removal of the hydroxyl radical by 35.69 % at the highest concentration and was able to prevent lipid peroxidation induced by 2,2"-azobis-2-amidinopropane (AAPH), inhibiting the amount of TBARS formed, up to 35.69 %, a result close to that obtained with AA. Hydroxyl Radical 53-61 L1 cell adhesion molecule Mus musculus 23-27 31815490-13 2020 The 200 picoseconds NVT well-tempered metadynamics at 300 K has been simulated to compute the OSV-MP2 rotational free energy surface of coupled hydroxyl and methyl rotors for ethanol molecule. Hydroxyl Radical 144-152 tryptase pseudogene 1 Homo sapiens 98-101 31527000-7 2020 The major intermediates were resulted from the attack of hydroxyl radicals to the ADDA side chains of MC-LR structure. Hydroxyl Radical 57-74 adducin 1 Homo sapiens 82-86 31777937-0 2020 A novel 5"-hydroxyl dinucleotide hydrolase activity for the DXO/Rai1 family of enzymes. Hydroxyl Radical 8-19 decapping exoribonuclease Mus musculus 60-63 31777937-0 2020 A novel 5"-hydroxyl dinucleotide hydrolase activity for the DXO/Rai1 family of enzymes. Hydroxyl Radical 8-19 retinoic acid induced 1 Mus musculus 64-68 31777937-4 2020 Here, we demonstrate that DXO also catalyzes the hydrolysis of RNAs bearing a 5"-hydroxyl group (5"-OH RNA). Hydroxyl Radical 78-89 decapping exoribonuclease Mus musculus 26-29 31777937-7 2020 Our nuclease assays confirm this prediction and demonstrate that this 5"-hydroxyl dinucleotide hydrolase (HDH) activity for DXO is higher than the subsequent 5"-3" exoribonuclease activity for selected substrates. Hydroxyl Radical 70-94 decapping exoribonuclease Mus musculus 124-127 31774220-1 2020 The origin of hydroxyl group tolerance in neutral and especially cationic molybdenum imido alkylidene N-heterocyclic carbene (NHC) complexes has been investigated. Hydroxyl Radical 14-22 high mobility group nucleosomal binding domain 4 Homo sapiens 102-130 31774220-4 2020 NHC complexes were successfully used with substrates containing the hydroxyl functionality in acyclic diene metathesis polymerization, homo-, cross and ring-opening cross metathesis reactions. Hydroxyl Radical 68-76 high mobility group nucleosomal binding domain 4 Homo sapiens 0-3 31590868-4 2020 The reactions mainly occur at the hydroxyl groups of C-6 positions of beta-chitin chains due to mild conditions, and the obtained beta-chitin derivatives with high DS values are water-soluble. Hydroxyl Radical 34-42 complement C6 Homo sapiens 53-56 31744341-2 2020 Catechol-O-methyltransferase (COMT, E.C 2.1.1.6) inactivates dopamine and other substrates bearing catechol through the methylation of a hydroxyl group. Hydroxyl Radical 137-145 catechol-O-methyltransferase Homo sapiens 0-28 31744341-2 2020 Catechol-O-methyltransferase (COMT, E.C 2.1.1.6) inactivates dopamine and other substrates bearing catechol through the methylation of a hydroxyl group. Hydroxyl Radical 137-145 catechol-O-methyltransferase Homo sapiens 30-34 31807868-10 2020 In conclusion, piperidine derivatives with hydroxyl substitution have a great therapeutic potential with an apoptotic rationale involving mitochondrial pathway, due to possible inhibition of parasitic thymidylate synthase. Hydroxyl Radical 43-51 thymidylate synthetase Homo sapiens 201-221 32405345-9 2020 Conclusion: The lowered frequency of K-ras mutations correlated with decreased formation of hydroxyl radicals, O5-meG and 8-OH-dG levels in phytate-supplemented animals with lowered tumor burden. Hydroxyl Radical 92-109 KRAS proto-oncogene, GTPase Rattus norvegicus 37-42 32493877-7 2020 Pretreatment with polyethylene glycol conjugated with CAT (PEG-CAT) abolished 9,10-PQ-generated H2O2 production and significantly blocked the activation of EGFR-ERK1/2 signaling by 9,10-PQ, indicating the involvement of H2O2 in the activation because scavenging agents for hydroxyl radicals had no effect on the redox signal activation. Hydroxyl Radical 273-290 catalase Homo sapiens 54-57 32493877-7 2020 Pretreatment with polyethylene glycol conjugated with CAT (PEG-CAT) abolished 9,10-PQ-generated H2O2 production and significantly blocked the activation of EGFR-ERK1/2 signaling by 9,10-PQ, indicating the involvement of H2O2 in the activation because scavenging agents for hydroxyl radicals had no effect on the redox signal activation. Hydroxyl Radical 273-290 catalase Homo sapiens 59-66 32493877-7 2020 Pretreatment with polyethylene glycol conjugated with CAT (PEG-CAT) abolished 9,10-PQ-generated H2O2 production and significantly blocked the activation of EGFR-ERK1/2 signaling by 9,10-PQ, indicating the involvement of H2O2 in the activation because scavenging agents for hydroxyl radicals had no effect on the redox signal activation. Hydroxyl Radical 273-290 epidermal growth factor receptor Homo sapiens 156-160 32493877-7 2020 Pretreatment with polyethylene glycol conjugated with CAT (PEG-CAT) abolished 9,10-PQ-generated H2O2 production and significantly blocked the activation of EGFR-ERK1/2 signaling by 9,10-PQ, indicating the involvement of H2O2 in the activation because scavenging agents for hydroxyl radicals had no effect on the redox signal activation. Hydroxyl Radical 273-290 mitogen-activated protein kinase 3 Homo sapiens 161-167 31629162-4 2019 In addition, by introducing a hydroxyl group, our compounds have significantly improved solubility and may target specific polar residues Arg57, Glu69 and Arg134 of Plk1. Hydroxyl Radical 30-38 eukaryotic translation initiation factor 3 subunit K Homo sapiens 155-161 31790227-3 2019 While significantly, the density functional theory calculations demonstrate that the observed high CO2RR catalytic activity originates not from the solo carboxyl or other oxygen-containing groups, but from the synergistic effect between carboxyl groups and adjacent other types of groups (namely hydroxyl, epoxide and carbonyl) on GNDs. Hydroxyl Radical 296-304 complement C2 Homo sapiens 99-104 31888039-2 2019 An increase in the hydrophilicity was observed after treatment of non-charged isoporous membranes from PS-b-P4VP-b-PSMA, through acidic hydrolysis of the hydrophobic poly(solketal methacrylate) PSMA block into a hydrophilic poly(glyceryl methacrylate) PGMA block, which contains two neighbored hydroxyl (-OH) groups per repeating unit. Hydroxyl Radical 294-302 folate hydrolase 1 Homo sapiens 115-119 31888039-2 2019 An increase in the hydrophilicity was observed after treatment of non-charged isoporous membranes from PS-b-P4VP-b-PSMA, through acidic hydrolysis of the hydrophobic poly(solketal methacrylate) PSMA block into a hydrophilic poly(glyceryl methacrylate) PGMA block, which contains two neighbored hydroxyl (-OH) groups per repeating unit. Hydroxyl Radical 294-302 folate hydrolase 1 Homo sapiens 194-198 31739665-4 2019 We herein describe a practical and predictable method for the site- and stereoselective alkylation of carbohy-drate hydroxyl groups via Rh(II)-catalyzed insertion of metal carbenoid intermediates. Hydroxyl Radical 102-124 Rh blood group D antigen Homo sapiens 136-141 31739665-6 2019 Density functional theory (DFT) calculations suggest that the site-selectivity is determined in the Rh(II)-carbenoid insertion step, which prefers insertion into hydroxyl groups with an adjacent axial substituent. Hydroxyl Radical 162-170 Rh blood group D antigen Homo sapiens 100-105 31703893-2 2019 In order to confirm key structural features to activate PPARalpha and/or PPARgamma, we have adopted structural modifications in the following parts: (i) the benzopyran core (hydrophobic nucleus) by benzopyran-4-one, dihydrobenzopyran or benzopyran-4-ol; (ii) the side chain at 2-position by shortening to C3, C4 and C5-carbons versus C-9-carbons of polycerasoidol; (iii) the carboxylic group (polar head) by oxygenated groups (hydroxyl, acetoxy, epoxide, ester, aldehyde) or non-oxygenated motifs (allyl and alkyl). Hydroxyl Radical 427-435 peroxisome proliferator activated receptor alpha Homo sapiens 56-65 31833366-3 2019 The GOx-driven oxidation reaction can effectively eliminate intratumoral glucose for starvation therapy, and the elevated H2O2 is then converted into highly toxic hydroxyl radicals via a Mn2+-mediated Fenton-like reaction for chemodynamic therapy (CDT). Hydroxyl Radical 163-171 hydroxyacid oxidase 1, liver Mus musculus 4-7 31777249-0 2019 An Approach to Tertiary Type beta-Hydroxyl Carboxamides Through Sc(OTf)3-Catalyzed Addition of Ynamides and Ketones. Hydroxyl Radical 34-55 POU class 5 homeobox 1 Homo sapiens 64-72 31777249-1 2019 An efficient approach to access functionalized tertiary type beta-hydroxyl carboxamides has been developed through Sc(OTf)3-catalyzed addition of ynamides and substituted ketones. Hydroxyl Radical 66-87 POU class 5 homeobox 1 Homo sapiens 115-123 31889992-6 2019 Introduction of O-glycosyl groups at the core skeleton decreased hCES inhibition activity, while the hydroxyl groups at different sites might also effect hCES inhibition. Hydroxyl Radical 101-109 cat eye syndrome chromosome region Homo sapiens 154-158 31629162-4 2019 In addition, by introducing a hydroxyl group, our compounds have significantly improved solubility and may target specific polar residues Arg57, Glu69 and Arg134 of Plk1. Hydroxyl Radical 30-38 polo like kinase 1 Homo sapiens 165-169 31568878-0 2019 Co-delivery of p53 and MDM2 inhibitor RG7388 using a hydroxyl terminal PAMAM dendrimer derivative for synergistic cancer therapy. Hydroxyl Radical 53-61 tumor protein p53 Homo sapiens 15-18 31791289-10 2019 Eicosanoid profile analysis showed that all PPARalpha ligands reduced the production of AA-derived epoxyeicosatrienoic acids (EETs) and increased the hydroxyl product, 11-hydroxyeicosatetraenoic acids (11-HETE). Hydroxyl Radical 150-158 peroxisome proliferator activated receptor alpha Mus musculus 44-53 31847126-2 2019 The serine/threonine hydroxyl-linked N-Acetylglucosamine (O-GlcNAc) transferase (OGT) has been shown to drive pulmonary arterial smooth muscle cell (PASMC) proliferation in IPAH. Hydroxyl Radical 11-29 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 58-66 31847126-2 2019 The serine/threonine hydroxyl-linked N-Acetylglucosamine (O-GlcNAc) transferase (OGT) has been shown to drive pulmonary arterial smooth muscle cell (PASMC) proliferation in IPAH. Hydroxyl Radical 11-29 O-linked N-acetylglucosamine (GlcNAc) transferase Homo sapiens 81-84 31713427-2 2019 Here we use atomic force microscopy (AFM) to probe the interfacial nanostructures of hydroxyl-functionalized ILs at negatively charged mica surfaces. Hydroxyl Radical 85-93 MHC class I polypeptide-related sequence A Homo sapiens 135-139 31568878-0 2019 Co-delivery of p53 and MDM2 inhibitor RG7388 using a hydroxyl terminal PAMAM dendrimer derivative for synergistic cancer therapy. Hydroxyl Radical 53-61 MDM2 proto-oncogene Homo sapiens 23-27 31586045-3 2019 As revealed by in vitro measurements and computations, the interaction between graphene/gold and HSA/IgE was inversely correlated with the hydroxyl group availability, whereas the interaction between that and ApoE was comparatively less relevant. Hydroxyl Radical 139-147 immunoglobulin heavy constant epsilon Homo sapiens 101-104 31885786-9 2019 Accumulation of hydroxyl derivatives and cardiolipin hydroperoxides has been observed in the affected tissues, and recent studies showed that oxidation of cardiolipin is carried out by a cardiolipin-specific peroxidase activity of cardiolipin-bound cytochrome c. Hydroxyl Radical 16-24 cytochrome c, somatic Homo sapiens 249-261 31697484-3 2019 The prepared MoS2/SnS2/r-GO showed significant photoexcitation of photosensitive oxygen (ROS) by electron spin resonance spectroscopy, demonstrating that superoxide radicals ( O2-), pores, and hydroxyl radicals ( OH) are the main active species. Hydroxyl Radical 193-201 sodium voltage-gated channel alpha subunit 11 Homo sapiens 18-22 31598619-2 2019 In the presence of PNK, cDNA with 5"-hydroxyl termini was phosphorylated and then hybridized with tDNA to form the cDNA/tDNA duplex, which subsequently triggered the lambda exonuclease cleavage reaction, eventually resulting in the release of tDNA. Hydroxyl Radical 34-45 polynucleotide kinase 3'-phosphatase Homo sapiens 19-22 31358209-4 2019 Experiments showed that the catalytic mechanism of CaF2 nanoparticles was attributed to that it could result in the decomposition of H2O2 to produce hydroxyl radicals ( OH). Hydroxyl Radical 149-166 CCR4-NOT transcription complex subunit 8 Homo sapiens 51-55 31401282-3 2019 The results of antioxidant assays indicated that PSP-1 had good DPPH radical scavenging activity, hydroxyl radical scavenging activity, cellular antioxidant activity, and reactive oxygen species inhibition activity, and could significantly improve cellular antioxidant enzymes of ABAP-induced HepG2 cell model. Hydroxyl Radical 98-114 paraspeckle component 1 Homo sapiens 49-54 31610507-7 2019 The abundant unsaturated metal active sites of Fe(II) and Co(II) in the skeleton of FeCo-BDC made a great contribution to the generation of sulfate () and hydroxyl radicals (OH), which resulted in the excellent performance for MB degradation. Hydroxyl Radical 155-163 mitochondrially encoded cytochrome c oxidase II Homo sapiens 58-64 32198338-8 2019 The order of active species affecting the photocatalytic degradation of TC by mpg-C3N4-ZIF-8 was hole > superoxide radical > hydroxyl radical. Hydroxyl Radical 125-141 N-methylpurine DNA glycosylase Homo sapiens 78-81 31763971-9 2021 Its mechanism is proposed that a nucleophilic addition of iron-peroxo species, generated by CYP2D6 and CYP3A4/5, to the carbonyl group caused the carbon-carbon bond cleavage between the adjacent hydroxyl and ketone groups. Hydroxyl Radical 195-203 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 92-98 31763971-9 2021 Its mechanism is proposed that a nucleophilic addition of iron-peroxo species, generated by CYP2D6 and CYP3A4/5, to the carbonyl group caused the carbon-carbon bond cleavage between the adjacent hydroxyl and ketone groups. Hydroxyl Radical 195-203 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 103-109 31685617-2 2019 Here hydroxyl radical footprinting coupled with mass spectrometry was employed to probe protein-protein interactions and conformational changes involved in the assembly of telomere ssDNA substrates of differing lengths bound by POT1-TPP1 heterodimers. Hydroxyl Radical 5-13 protection of telomeres 1 Homo sapiens 228-232 31685617-2 2019 Here hydroxyl radical footprinting coupled with mass spectrometry was employed to probe protein-protein interactions and conformational changes involved in the assembly of telomere ssDNA substrates of differing lengths bound by POT1-TPP1 heterodimers. Hydroxyl Radical 5-13 tripeptidyl peptidase 1 Homo sapiens 233-237 31647663-4 2019 We report that a hydroxyl-functionalized, 2.5 nm in size cuboctahedral Rh(II)-based MOP can be transferred between immiscible phases by pH changes or by cation-exchange reactions. Hydroxyl Radical 17-25 Rh blood group D antigen Homo sapiens 71-76 31228832-2 2019 ESR tests illustrate that the three catalysts can catalyze decomposition of H2O2 yielding highly reactive hydroxyl radicals, of which Fe/K10 has the fastest rate, followed by Fe/gamma-alumina. Hydroxyl Radical 106-123 keratin 10 Homo sapiens 137-140 31228832-5 2019 Interestingly, Fe/ZSM-5 has the lowest efficiency in generating hydroxyl radicals, its NO removal efficiency is 90%, which is much higher than 47.5% for Fe/gamma-alumina and 62.3% for Fe/K10. Hydroxyl Radical 64-81 keratin 10 Homo sapiens 187-190 31872743-7 2019 These results suggested that the flavonoid mother nucleus structure had a special structure binding to the enzyme protein UGT1 A1,and the introduction of hydroxyl groups into the mother nucleus can increase the binding ability. Hydroxyl Radical 154-162 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 122-129 31464312-4 2019 A crystal growth model involving assembly and coalescence was developed to describe the crystal growth and the corresponding PL properties, where hydroxyl-motivated hydrogen-bonding interaction was used to explain the oriented assembly of CdS QDs. Hydroxyl Radical 146-154 CDP-diacylglycerol synthase 1 Homo sapiens 239-242 31667250-6 2019 The FTIR data showed phosphate and hydroxyl peaks in the thermally treated samples and all the samples produced characteristic stretching modes of O-H bands at about 3417 cm-1 which are noticed in all FTIR spectra of HAp. Hydroxyl Radical 35-43 reticulon 3 Homo sapiens 217-220 31227352-3 2019 Our results indicate that HCO3- may play a dual role to act 1) as a ligand to stabilize Cu(II), forming soluble [CuII(HCO3-)(S)]+ species to catalyze H2O2 producing hydroxyl radical (OH) and superoxide ion (O2-) and 2) as a OH scavenger. Hydroxyl Radical 165-181 TRAF3 interacting protein 2 Homo sapiens 56-61 31461879-1 2019 A novel poly(arylene ether nitrile) terminated with hydroxyl groups (PEN-OH) was synthesized successfully. Hydroxyl Radical 52-60 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 69-72 31398794-5 2019 Ozone, hydroxyl radical (HO ), and sulfate radical (SO4 -) were identified as contributors for ACE degradation and their contribution proportion was 27.1%, 25.4%, and 47.5% respectively. Hydroxyl Radical 7-23 angiotensin I converting enzyme Homo sapiens 95-98 31398794-5 2019 Ozone, hydroxyl radical (HO ), and sulfate radical (SO4 -) were identified as contributors for ACE degradation and their contribution proportion was 27.1%, 25.4%, and 47.5% respectively. Hydroxyl Radical 25-27 angiotensin I converting enzyme Homo sapiens 95-98 31398794-7 2019 The qualitative analysis of degradation products confirmed the involvement of hydroxyl radical and sulfate radical and figured out that the active sites of ACE were the C=C bond, ether bond, and C-N bond. Hydroxyl Radical 78-94 angiotensin I converting enzyme Homo sapiens 156-159 31082641-4 2019 In surface water, the attack of BP3 by hydroxyl radicals (HO ) or carbonate radicals (CO3 -) in UV/H2O2 can generate BP8, which was responsible for the relatively high degradation rate of BP3. Hydroxyl Radical 39-56 BP3 Homo sapiens 32-35 31082641-4 2019 In surface water, the attack of BP3 by hydroxyl radicals (HO ) or carbonate radicals (CO3 -) in UV/H2O2 can generate BP8, which was responsible for the relatively high degradation rate of BP3. Hydroxyl Radical 39-56 BP8 Homo sapiens 117-120 31082641-4 2019 In surface water, the attack of BP3 by hydroxyl radicals (HO ) or carbonate radicals (CO3 -) in UV/H2O2 can generate BP8, which was responsible for the relatively high degradation rate of BP3. Hydroxyl Radical 58-60 BP3 Homo sapiens 188-191 31082641-4 2019 In surface water, the attack of BP3 by hydroxyl radicals (HO ) or carbonate radicals (CO3 -) in UV/H2O2 can generate BP8, which was responsible for the relatively high degradation rate of BP3. Hydroxyl Radical 39-56 BP3 Homo sapiens 188-191 31082641-4 2019 In surface water, the attack of BP3 by hydroxyl radicals (HO ) or carbonate radicals (CO3 -) in UV/H2O2 can generate BP8, which was responsible for the relatively high degradation rate of BP3. Hydroxyl Radical 58-60 BP3 Homo sapiens 32-35 31082641-4 2019 In surface water, the attack of BP3 by hydroxyl radicals (HO ) or carbonate radicals (CO3 -) in UV/H2O2 can generate BP8, which was responsible for the relatively high degradation rate of BP3. Hydroxyl Radical 58-60 BP8 Homo sapiens 117-120 30986595-7 2019 Results indicated that TP 1 was generated by the hydroxyl that substituted for chlorine, TP 2 was formed by the cleavage of the ether bond of tefuryltrione, and TPs 3-6 were formed by the breakage of the CC bond of the keto moiety of tefuryltrione. Hydroxyl Radical 49-57 transition protein 1 Homo sapiens 23-27 30986453-4 2019 CAP-3 exhibited strong antioxidant activity against DPPH (IC50: 0.78 mg/mL), hydroxyl radicals (IC50: 0.84 mg/mL) and also showed synergistic antioxidative effect with ascorbic acid in vitro. Hydroxyl Radical 77-94 serine (or cysteine) peptidase inhibitor, clade B, member 9 Mus musculus 0-5 31117353-5 2019 Numerous phenolic and aliphatic hydroxyl moieties exist in the side chains of lignin, which donate adequate reactive sites for chelation with Ca2+ and the subsequent nucleation of HAp through coprecipitation of Ca2+ and PO43-. Hydroxyl Radical 32-40 reticulon 3 Homo sapiens 180-183 31153952-6 2019 l-Dehydroascorbic acid (DHA), an oxidized form of AsA, necessitated the presence of 25-50 muM DTT or sub-millimolar concentrations of GSH and NAC for the scavenging of hydroxyl radicals and failed to scavenge hydroxyl radicals by itself. Hydroxyl Radical 168-185 latexin Homo sapiens 90-93 31153952-6 2019 l-Dehydroascorbic acid (DHA), an oxidized form of AsA, necessitated the presence of 25-50 muM DTT or sub-millimolar concentrations of GSH and NAC for the scavenging of hydroxyl radicals and failed to scavenge hydroxyl radicals by itself. Hydroxyl Radical 209-226 latexin Homo sapiens 90-93 31065979-8 2019 XRD and FTIR analysis revealed the adsorption mechanism of Pb(II) and Cd(II) ions on MgO, which was mainly due to hydroxyl functional groups and ion exchange between Mg and heavy metal ions on the surface of MgO. Hydroxyl Radical 114-122 submaxillary gland androgen regulated protein 3B Homo sapiens 59-65 31608872-5 2019 The antioxidant properties of FCP were assessed in vitro based on scavenging effect of the DPPH radical, hydroxyl radical and super oxide radical tests. Hydroxyl Radical 105-113 FCP1 Homo sapiens 30-33 31353707-7 2019 In antioxidant activity tests, DIP-1 exhibited powerful scavenging activities on hydroxyl, DPPH, ABTS radicals and reducing power in a dose-dependent manner. Hydroxyl Radical 81-89 cyclin D1 binding protein 1 Homo sapiens 31-36 31608872-7 2019 The results on hydroxyl radical demonstrated that FCP exhibited high scavenging effect when the concentration was over 3000mug/mL. Hydroxyl Radical 15-23 FCP1 Homo sapiens 50-53 31048244-1 2019 In order to study the effects of peptide exposure to oxidative attack, we chose a model reaction in which the hydroxyl radical discretely abstracts a hydrogen atom from the alpha-carbon of each residue of a highly amyloidogenic region in the human calcitonin hormone, hCT15-19. Hydroxyl Radical 110-126 ADAM metallopeptidase domain 2 Homo sapiens 268-273 31003152-7 2019 RESULTS: Compared to the control group, liver cells from apoE-KO presented some typical redox imbalance features: higher levels of intracellular ROS (global oxidative stress ~60%, superoxide anion ~82%, and peroxynitrite/hydroxyl radical ~53%), higher amounts of apoptotic cells (up to ~19%) and higher mitochondrial intensity of catalase (+339%) and transferrin spots (+914%). Hydroxyl Radical 221-237 apolipoprotein E Mus musculus 57-61 31091187-8 2019 The hydroxyl radical quencher, thiourea, and the superoxide dismutase mimic, TEMPOL, significantly reduced hydroxyl radical and superoxide levels, respectively, in the antibiotic-exposed SCs and NCs and thereby decreased their differential susceptibility to antibiotics. Hydroxyl Radical 4-20 chromosome 1 open reading frame 210 Homo sapiens 77-83 31020285-3 2019 In addition, the NHC-catalyzed sulfa-Michael-aldol cascade reaction between o-formyl chalcone and thiols has also been demonstrated to afford sulfenylated indanes with a free hydroxyl group in moderate yields and good diastereoselectivity. Hydroxyl Radical 175-183 high mobility group nucleosomal binding domain 4 Homo sapiens 17-20 30979724-7 2019 Using steady-state hydroxyl radical labeling, we identified sites of interaction between the FRP and OCP. Hydroxyl Radical 19-35 secreted frizzled related protein 1 Homo sapiens 93-96 31058483-4 2019 In this nanoreactor, the encapsulated GOx served as the primary catalyst that accelerated oxidation of glucose and generation of H2O2, while the covalently linked ferrocene worked as the secondary catalyst for converting the upstream H2O2 to more toxic hydroxyl radicals ( OH) via a classic Fenton reaction. Hydroxyl Radical 253-270 hydroxyacid oxidase 1 Homo sapiens 38-41 30978018-11 2019 Both these modifications and blocking all three hydroxyl groups resulted in TRPM2 antagonists. Hydroxyl Radical 48-56 transient receptor potential cation channel subfamily M member 2 Homo sapiens 76-81 30797456-3 2019 In this system, Cyt c was hydrolyzed by trypsin, and the resulting heme-peptide fragment exhibited peroxidase-like activity for catalytic decomposition of H2O2 into hydroxyl radical ( OH). Hydroxyl Radical 165-181 cytochrome c, somatic Homo sapiens 16-21 30995050-1 2019 An asymmetric synthesis of C14-desmethylene corialactone D is described on the basis of strategic application of a metallacycle-mediated annulative cross-coupling reaction, a Still [2,3]-Wittig rearrangement, and Morken"s hydroxyl-directed diboration reaction. Hydroxyl Radical 222-230 anti-Mullerian hormone receptor type 2 Rattus norvegicus 27-30 30822161-5 2019 SULT1E1 catalyzes the transfer of a sulfate group from 3"-phosphoadenosine-5"-phosphosulfate (PAPS) to any available hydroxyl group in estrogenic molecules. Hydroxyl Radical 117-125 sulfotransferase family 1E member 1 Homo sapiens 0-7 31052144-4 2019 The results revealed that the nitramine reinforcement of the three polar groups to CL-20 was in the order cyano group > hydroxyl group > ester group. Hydroxyl Radical 123-131 epithelial membrane protein 1 Homo sapiens 83-88 30960582-0 2019 A New Strategy for the Synthesis of Hydroxyl Terminated Polystyrene-b-Polybutadiene-b-Polystyrene Triblock Copolymer with High Cis-1, 4 Content. Hydroxyl Radical 36-44 suppressor of cytokine signaling 1 Homo sapiens 127-132 30960582-1 2019 This work reports the preparation of a hydroxyl terminated polystyrene-b-polybutadiene-b-polystyrene triblock copolymer (SBS) with high cis-1, 4 content via a novel nickel catalyst, [eta3-Ni(CH2CHCHCH2OOCH3)][BPhF4]. Hydroxyl Radical 39-47 suppressor of cytokine signaling 1 Homo sapiens 136-141 30955337-4 2019 The bridgehead hydroxyl moiety at C11 was installed through a late-stage cobalt-catalyzed decarboxylative acetoxylation reaction. Hydroxyl Radical 15-23 RNA polymerase III subunit K Homo sapiens 34-37 30942830-1 2019 Oxidation of aorta by hydroxyl radicals produces structural changes in arterial proteins like elastin and collagen, which results in change in the mechanical response of aorta. Hydroxyl Radical 22-39 elastin Homo sapiens 94-101 30779137-4 2019 PF-A and PF-B demonstrated similar scavenging activity of free radical (DPPH, ABTS, hydroxyl radical, superoxide anion). Hydroxyl Radical 84-100 keratin 75 Homo sapiens 9-13 30537583-5 2019 Furtherly, the generation of hydroxyl radicals (OH) via a chain reaction in O3 was ascertained based on indirect alcohols quenching tests and direct electron spin resonance (ESR) spin-trapping tests, though high initial SPC concentration led to no trapping of OH by 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) in O3/SPC. Hydroxyl Radical 29-46 proline rich protein gene cluster Homo sapiens 220-223 30777436-1 2019 The central phosphorus atom of a novel hydroxyl-functionalized triarylphosphane was shown to reversibly insert into one of the molecule"s O-H bonds, which forms the basis for a tautomeric lambda3/lambda5-phosphane equilibrium. Hydroxyl Radical 39-47 immunoglobulin lambda like polypeptide 1 Homo sapiens 196-203 30833722-5 2019 Crystal structures of murine IRE1 in complex with covalently bound hydroxyl aryl aldehyde (HAA) inhibitors show that these molecules form hydrophobic interactions with His910 and Phe889, a hydrogen bond with Tyr892 and an indispensable Schiff-base with Lys907. Hydroxyl Radical 67-75 endoplasmic reticulum (ER) to nucleus signalling 2 Mus musculus 29-33 30779137-5 2019 The scavenging activity of PF-A and PF-B on hydroxyl radical and superoxide anion radical reached the equal levels of vitamin C and gallic acid. Hydroxyl Radical 44-60 keratin 75 Homo sapiens 36-40 30644750-3 2019 With lower internal energies, syn-CH3CHOO prefers isomerizing to vinyl hydroperoxide, which then produces hydroxyl radical. Hydroxyl Radical 106-122 synemin Homo sapiens 30-33 30576885-6 2019 Levels of oxidative protein nitration and lipid peroxidation are reduced in muscle and brain tissues of UOX+/- mice under conditions of metabolic and oxidative stress (running in the case of muscle and ischemia in the case of the brain), consistent with prior evidence that UA can scavenge peroxynitrite and hydroxyl radical. Hydroxyl Radical 308-324 urate oxidase Mus musculus 104-107 30703319-0 2019 Two-Dimensional Hydroxyl-Functionalized and Carbon-Deficient Scandium Carbide, ScC xOH, a Direct Band Gap Semiconductor. Hydroxyl Radical 16-24 serpin family B member 3 Homo sapiens 79-82 30715865-2 2019 This Communication describes, employing SnO x as a model system, how to moderate coverage of hydroxyl to derive a stable Sn branches catalyst for CO2ER with a 93.1% Faradaic efficiency (FE) of carbonaceous products. Hydroxyl Radical 93-101 strawberry notch homolog 2 Homo sapiens 40-43 30101285-0 2019 Hydroxyl radical-induced early stage oxidation improves the foaming and emulsifying properties of ovalbumin. Hydroxyl Radical 0-16 ovalbumin (SERPINB14) Gallus gallus 98-107 30328005-0 2019 Exposure of Solvent-Inaccessible Regions in the Amyloidogenic Protein Human SOD1 Determined by Hydroxyl Radical Footprinting. Hydroxyl Radical 95-111 superoxide dismutase 1 Homo sapiens 76-80 30101285-2 2019 The present study investigated the effects of hydroxyl radical-induced early stage oxidation on the physicochemical and interfacial properties of chicken egg white ovalbumin. Hydroxyl Radical 46-62 ovalbumin (SERPINB14) Gallus gallus 164-173 30101285-4 2019 Sodium dodecyl sulfate polyacrylamide gel electrophoresis analysis showed that the exposure of ovalbumin to hydroxyl radicals caused self-cross-linking and resulted in the formation of dimers and trimers. Hydroxyl Radical 108-125 ovalbumin (SERPINB14) Gallus gallus 95-104 30101285-7 2019 Hydroxyl radical-induced oxidation changed the surface chemical groups and structures of ovalbumin, thereby affecting the surface properties. Hydroxyl Radical 0-16 ovalbumin (SERPINB14) Gallus gallus 89-98 30287368-4 2018 Pharmacological results revealed that PIP-1 could effectively scavenge hydroxyl radicals, partly scavenge DPPH radials and chelate ferrous metal ions. Hydroxyl Radical 71-88 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 38-43 30415363-6 2019 FTIR and EDX results suggest that Pb2+ might have bonded to phenolic, carboxylic, hydroxyl, and amine groups; they also show formation of organometallic complexes and cationic exchange between the compost and the solution. Hydroxyl Radical 82-90 vacuolar-processing enzyme Nicotiana tabacum 34-37 30543161-6 2019 RESULTS: We demonstrate the utility of the Pyrite Shrink-Wrap Laminate for the chemical generation of hydroxyl radicals by mapping the surface of the T-cell co-stimulatory protein Programmed Death - 1 (PD-1) and the interface of the complex with its ligand PD-L1. Hydroxyl Radical 102-119 programmed cell death 1 Homo sapiens 180-200 30543161-6 2019 RESULTS: We demonstrate the utility of the Pyrite Shrink-Wrap Laminate for the chemical generation of hydroxyl radicals by mapping the surface of the T-cell co-stimulatory protein Programmed Death - 1 (PD-1) and the interface of the complex with its ligand PD-L1. Hydroxyl Radical 102-119 programmed cell death 1 Homo sapiens 202-206 30543161-6 2019 RESULTS: We demonstrate the utility of the Pyrite Shrink-Wrap Laminate for the chemical generation of hydroxyl radicals by mapping the surface of the T-cell co-stimulatory protein Programmed Death - 1 (PD-1) and the interface of the complex with its ligand PD-L1. Hydroxyl Radical 102-119 CD274 molecule Homo sapiens 257-262 30562453-4 2019 On the other hand, a well-designed hairpin DNA1 probe with 5"-hydroxyl termini was specifically phosphorylated by T4 PNK which would be selectively cleaved with lambda exonuclease (lambda-Exo) outputting the 3"-thiol end ssDNA2. Hydroxyl Radical 62-70 polynucleotide kinase 3'-phosphatase Homo sapiens 117-120 30121436-5 2018 X-ray photoelectron spectra and Fourier transformation infrared spectra suggested solar irradiation destroyed the key DBP precursors containing phenolic hydroxyl moieties (Ph-OH). Hydroxyl Radical 153-161 D site-binding protein Cricetulus griseus 118-121 30222979-3 2018 Using recombinant human enzyme, we discovered that cytochrome b5 reductase mediates redox cycling of a variety of quinones generating superoxide anion, hydrogen peroxide, and, in the presence of transition metals, hydroxyl radicals. Hydroxyl Radical 214-231 cytochrome b5 type A Homo sapiens 51-64 30118955-6 2018 XPS indicated that the Fe0/Cu0 reduction reaction of hydroxyl radicals ( OH) system played a significant role in degradation of DC13 and the LC-MS result suggested that DC13 was degraded into inorganic small molecules by OH radicals generated from the corrosion of Fe0. Hydroxyl Radical 53-70 C-X9-C motif containing 2 Homo sapiens 128-132 30118955-6 2018 XPS indicated that the Fe0/Cu0 reduction reaction of hydroxyl radicals ( OH) system played a significant role in degradation of DC13 and the LC-MS result suggested that DC13 was degraded into inorganic small molecules by OH radicals generated from the corrosion of Fe0. Hydroxyl Radical 53-70 C-X9-C motif containing 2 Homo sapiens 169-173 30143133-6 2018 The antioxidant capacity of SF by ESR showed high elimination index (IC50, mg/mL) of hydroxyl (0.27), alkoxy (10.05), and peroxyl (82.88) radicals in relation to commercial mannitol. Hydroxyl Radical 85-93 esterase 5 regulator Mus musculus 34-37 30424581-3 2018 MEOS induction accelerates the metabolism of ethanol to acetaldehyde that facilitates organ injury including the liver, and it produces via CYP 2E1 many reactive oxygen species (ROS) such as ethoxy radical, hydroxyethyl radical, acetyl radical, singlet radical, superoxide radical, hydrogen peroxide, hydroxyl radical, alkoxyl radical, and peroxyl radical. Hydroxyl Radical 301-317 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 140-147 30364385-2 2018 The number and location of phenolic hydroxyl of the flavonoids will significantly influence the inhibition of tyrosinase activity. Hydroxyl Radical 36-44 tyrosinase Rattus norvegicus 110-120 29953890-6 2018 MP1 possessed a moderate antioxidant activity in vitro in DPPH, ABTS, superoxide and hydroxyl radicals scavenging, Fe2+ chelating, lipid peroxidation inhibition and reducing power assays. Hydroxyl Radical 85-102 pitrilysin metallepetidase 1 Mus musculus 0-3 29953891-0 2018 Importance of the hydroxyl substituents in the B-ring of plant flavonols on their preferential binding interactions with VEGF G-quadruplex DNA: Multi-spectroscopic and molecular modeling studies. Hydroxyl Radical 18-26 vascular endothelial growth factor A Homo sapiens 121-125 30044956-4 2018 Reactive oxygen species (ROS) such as singlet oxygen [O2-] and hydroxyl radicals result in nonspecific reactivity, thus involved in several pathological conditions such as inflammation and reperfusion injury leading to damage of different biological molecules due to the production of enzyme myeloperoxidase because of activation of neutrophils in these diseases. Hydroxyl Radical 63-80 myeloperoxidase Homo sapiens 292-307 30345445-4 2018 Owing to the ultrahigh sensitivity of the ss-DNA to the hydroxyl radical, the proposed fluorescence immunoassay exhibited a favorable dynamic linear detection of AFB1 ranging from 0.46 pg mL-1 to 400 pg mL-1 with an good half maximal inhibitory concentration and limit of detection of 6.13 and 0.15 pg mL-1, respectively. Hydroxyl Radical 56-72 2'-5' oligoadenylate synthetase 1B Mus musculus 203-207 30345445-4 2018 Owing to the ultrahigh sensitivity of the ss-DNA to the hydroxyl radical, the proposed fluorescence immunoassay exhibited a favorable dynamic linear detection of AFB1 ranging from 0.46 pg mL-1 to 400 pg mL-1 with an good half maximal inhibitory concentration and limit of detection of 6.13 and 0.15 pg mL-1, respectively. Hydroxyl Radical 56-72 2'-5' oligoadenylate synthetase 1B Mus musculus 203-207 30347803-8 2018 In addition, the scavenging capability of PSC-MC on hydroxyl radical and superoxide anion radical was higher than those of DPPH radical and ABTS radical, which suggested that ASC-SC and PSC-SC might be served as hydroxyl radical and superoxide anion radical scavenger in cosmeceutical products for protecting skins from photoaging and ultraviolet damage. Hydroxyl Radical 212-228 PYD and CARD domain containing Homo sapiens 175-178 29894785-0 2018 Hydroxyl-related differences for three dietary flavonoids as inhibitors of human purine nucleoside phosphorylase. Hydroxyl Radical 0-8 purine nucleoside phosphorylase Homo sapiens 81-112 29894785-1 2018 In this work, the hydroxyl-related differences of binding properties and inhibitory activities of dietary flavonoids, namely chrysin, baicalein and apigenin against purine nucleoside phosphorylase (PNP) were investigated. Hydroxyl Radical 18-26 purine nucleoside phosphorylase Homo sapiens 165-196 29894785-1 2018 In this work, the hydroxyl-related differences of binding properties and inhibitory activities of dietary flavonoids, namely chrysin, baicalein and apigenin against purine nucleoside phosphorylase (PNP) were investigated. Hydroxyl Radical 18-26 purine nucleoside phosphorylase Homo sapiens 198-201 30030176-3 2018 The PDA@Au-HAp NPs produce hydroxyl radicals (OH) via catalysis of a small concentration of H2O2 to render bacteria more vulnerable to the temperature change. Hydroxyl Radical 27-44 hemaglutinin-associated protein Escherichia coli 11-14 29802924-6 2018 Importantly, fraction RRP1 demonstrated stronger antioxidative activities than RRP2 by scavenging DPPH, hydroxyl and superoxide anion radicals in vitro. Hydroxyl Radical 104-112 ribosomal RNA processing 1 Mus musculus 22-26 29802924-6 2018 Importantly, fraction RRP1 demonstrated stronger antioxidative activities than RRP2 by scavenging DPPH, hydroxyl and superoxide anion radicals in vitro. Hydroxyl Radical 104-112 ribosome binding protein 1 Mus musculus 79-83 29974476-7 2018 According to the in silico analysis, "hydroxyl radical" and "hydrogen peroxide" compounds were among the most central nodes of the network, and were within the shortest paths connecting "glucose" to "MMP7." Hydroxyl Radical 37-54 matrix metallopeptidase 7 Homo sapiens 200-204 29990814-4 2018 Firstly, the addition of EDDS could enhance hydroxyl radical generation by ZVI and oxygen for the oxidation of PCB including distribution in the soil phase and dissolved form in the aqueous phase. Hydroxyl Radical 44-60 pyruvate carboxylase Homo sapiens 111-114 30030176-9 2018 The PDA@Au-HAp NPs produce hydroxyl radicals (OH) via catalysis of a small concentration of H2O2 to render bacteria more vulnerable to temperature change. Hydroxyl Radical 27-44 hemaglutinin-associated protein Escherichia coli 11-14 29689475-4 2018 Especially, hydroxyl (HBD/HBA) substituent at position 3 or 4 on phenyl ring B showed potent IL-5 inhibition. Hydroxyl Radical 12-20 interleukin 5 Homo sapiens 93-97 29523248-3 2018 While the inhibited photocurrent of the KMnO4 treated FTO/TiO2/CDs electrode can be restored by ascorbic acid (AA) because of the regeneration of electron donating hydroxyls to promote electron-hole separation. Hydroxyl Radical 164-173 FTO alpha-ketoglutarate dependent dioxygenase Homo sapiens 54-57 29702455-9 2018 The facilitated cycle of CoII/CoIII played a crucial role in the generation of sulfate radicals, hydroxyl radicals and singlet oxygen. Hydroxyl Radical 97-114 mitochondrially encoded cytochrome c oxidase II Homo sapiens 25-29 29702455-9 2018 The facilitated cycle of CoII/CoIII played a crucial role in the generation of sulfate radicals, hydroxyl radicals and singlet oxygen. Hydroxyl Radical 97-114 mitochondrially encoded cytochrome c oxidase III Homo sapiens 30-35 30005897-4 2018 METHODS: An electron spin resonance method with a highly sensitive detection system was utilized to monitor hydroxyl radicals generated from two distinct normal human epidermal melanocyte lines with different levels of tyrosinase activity after the addition of various amounts of rhododendrol. Hydroxyl Radical 108-125 tyrosinase Homo sapiens 219-229 30005897-6 2018 RESULTS: Hydroxyl radicals were generated depending on the amounts of rhododendrol and/or tyrosinase. Hydroxyl Radical 9-26 tyrosinase Homo sapiens 90-100 30074392-3 2018 In particular, unimolecular decay of MVK-OO is predicted to be the major source of hydroxyl radicals (OH) in isoprene ozonolysis. Hydroxyl Radical 83-100 mevalonate kinase Homo sapiens 37-40 29655889-6 2018 TLP-1 from water elution possessed of higher reducing power and scavenging activities against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, superoxide radical and hydroxyl radical than TLP-2 eluted by 0.1M of NaCl. Hydroxyl Radical 163-179 telomerase associated protein 1 Homo sapiens 0-5 29655889-6 2018 TLP-1 from water elution possessed of higher reducing power and scavenging activities against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, superoxide radical and hydroxyl radical than TLP-2 eluted by 0.1M of NaCl. Hydroxyl Radical 163-179 cysteine rich protein 3 Homo sapiens 0-3 29274533-1 2018 In this work, magnesium ferrite (MgFe2O4) nano-platelets with rich defects and abundant surface hydroxyl groups were synthesized, and used for the removal of low concentration As(V) in aqueous solution. Hydroxyl Radical 96-104 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 176-181 29664293-2 2018 Normally, PMS is activated by the input of energy or reducing agent to generate sulfate or hydroxyl radicals or both. Hydroxyl Radical 91-108 proline rich protein BstNI subfamily 1 Homo sapiens 10-13 29964990-8 2018 The removal rates of 2-MIB and GSM decreased appreciably by 40% and 31%, respectively, when 1 mmol L-1tert-butanol was added to the reaction mixture, which indicated that hydroxyl radicals ( OH) played a major role in the removal of these typical odorants. Hydroxyl Radical 171-188 MIB E3 ubiquitin protein ligase 1 Homo sapiens 23-26 29526807-8 2018 Taken together, these data suggest that the overexpression of QR2 in brain cells in the presence of catechol quinones might lead to ROS-induced cell death via the rapid conversion of superoxide radicals into hydrogen peroxide and then into highly reactive hydroxyl radicals. Hydroxyl Radical 256-273 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 62-65 29146339-0 2018 Proteomic profiling of oxidized cysteine and methionine residues by hydroxyl radicals in myosin of pork. Hydroxyl Radical 68-85 myosin heavy chain 14 Homo sapiens 89-95 29499069-5 2018 PIC1 showed dose-dependent antioxidant activity in a total antioxidant (TAC) assay, hydroxyl radical antioxidant capacity (HORAC) assay, oxygen radical antioxidant capacity (ORAC) assay as well as the thiobarbituric acid reactive substances (TBARS) assay to screen for PIC1 antioxidant activity in human plasma. Hydroxyl Radical 84-92 small ubiquitin like modifier 1 Homo sapiens 0-4 29341606-6 2018 At the dyad axis, however, hOGG1 activity is suppressed, even at lesions predicted to be solution accessible by hydroxyl radical footprinting (HRF). Hydroxyl Radical 112-128 8-oxoguanine DNA glycosylase Homo sapiens 27-32 29431443-1 2018 The vinyl hydroperoxide (VHP), the major isomerization product of the syn-alkyl Criegee intermediate (CI) formed in alkene ozonolysis, is a direct precursor of hydroxyl radical (OH), the most important oxidant in the troposphere. Hydroxyl Radical 160-176 synemin Homo sapiens 70-73 29289023-5 2018 This means that the hydroxyl and sulfate radicals mediated oxidation and the direct electrolysis are inefficient for breaking the C-S, C-F and S-N bounds of the NTf2- anion, which is a very interesting mechanistic information to understand the complex processes undergone in electrolysis with diamond. Hydroxyl Radical 20-28 nuclear transport factor 2 Homo sapiens 161-165 29127234-8 2018 In conclusion, the increased oxidative stress in the SHR aorta (mainly increased production of H2O2 and its partially reduced product, hydroxyl radical) contributed to acetylcholine-induced, endothelium-dependent contractions; PPAR-alpha agonists likely inhibit the H2O2-mediated contractions by inhibiting endothelial Ca2+-independent PLA2. Hydroxyl Radical 135-151 peroxisome proliferator activated receptor alpha Rattus norvegicus 227-237 29127234-8 2018 In conclusion, the increased oxidative stress in the SHR aorta (mainly increased production of H2O2 and its partially reduced product, hydroxyl radical) contributed to acetylcholine-induced, endothelium-dependent contractions; PPAR-alpha agonists likely inhibit the H2O2-mediated contractions by inhibiting endothelial Ca2+-independent PLA2. Hydroxyl Radical 135-151 phospholipase A2 group IB Rattus norvegicus 336-340 29610567-2 2018 The effect of cavitation bubble collapse-derived hydroxyl radicals on the aggregation behavior of human serum albumin (HSA) was investigated. Hydroxyl Radical 49-66 albumin Homo sapiens 104-117 29253221-3 2018 Using purified recombinant proteins and high-throughput sequencing combined with Fe-BABE directed hydroxyl radical probing (HTS-BABE) we have characterized the interaction between Upf1 and the yeast 80S ribosome. Hydroxyl Radical 98-114 ATP-dependent RNA helicase NAM7 Saccharomyces cerevisiae S288C 180-184 30966254-7 2018 The structure, molecular weight, and molecular weight distribution of the hydroxyl-terminated PBA have been studied by 1H, 13C NMR, and GPC results. Hydroxyl Radical 74-82 glycophorin C (Gerbich blood group) Homo sapiens 136-139 29780471-3 2018 Oxidation of MFM-300(VIII) {[VIII2(OH)2(L)], LH4 = biphenyl-3,3",5,5"-tetracarboxylic acid} is accompanied by deprotonation of the bridging hydroxyl groups to afford isostructural MFM-300(VIV), [VIV2O2(L)]. Hydroxyl Radical 140-148 cytochrome c oxidase subunit 8A Homo sapiens 21-25 29253221-5 2018 Using the cleavage sites identified by hydroxyl radical probing and high-resolution structures of both yeast Upf1 and the human 80S ribosome, we provide a model of a Upf1:80S structure. Hydroxyl Radical 39-55 UPF1 RNA helicase and ATPase Homo sapiens 166-170 29196839-5 2018 In addition, crude UTP, UTP-1 and UTP-2 showed dose-dependent DPPH and hydroxyl radical scavenging and reducing activities. Hydroxyl Radical 71-87 PWP2 small subunit processome component Homo sapiens 24-29 29120818-3 2018 An NIR dye-conjugated hydroxyl radical generating biodegradable polymer (HRGP-IR) is employed as a theranostic nanoplatform. Hydroxyl Radical 22-38 histidine-rich glycoprotein Mus musculus 73-77 29120818-4 2018 HRGP-IR could self-assemble to form micelles and elevate oxidative stress by generating hydrogen peroxide and hydroxyl radical. Hydroxyl Radical 110-126 histidine-rich glycoprotein Mus musculus 0-4 29258803-10 2018 Herein, polymer capsules loaded with catalase and functionalized with an external layer of tannic acid are fabricated, which can efficiently scavenge important reactive oxygen species (i.e., hydroxyl radicals and hydrogen peroxide) and modulate extracellular matrix activity in an in vitro inflammation model of nucleus pulposus. Hydroxyl Radical 191-208 catalase Homo sapiens 37-45 29196839-5 2018 In addition, crude UTP, UTP-1 and UTP-2 showed dose-dependent DPPH and hydroxyl radical scavenging and reducing activities. Hydroxyl Radical 71-87 NOP14 nucleolar protein Homo sapiens 34-39 30533342-2 2018 Here we report how hydroxyl radicals ( OH) injected on the surface of water react with SP-B1-25, a 25-residue polypeptide surrogate of human lung surfactant protein B. Hydroxyl Radical 19-36 prolyl 3-hydroxylase 3 Homo sapiens 157-166 29172473-7 2018 Results were consistent with a free radical chain scission mechanism, supported by measurements of sub-muM hydroxyl radical concentrations. Hydroxyl Radical 107-123 latexin Homo sapiens 103-106 28745222-0 2018 Impact of Hydroxyl Radical Modified-Human Serum Albumin Autoantigens in Systemic Lupus Erythematosus. Hydroxyl Radical 10-26 albumin Homo sapiens 48-55 28745222-5 2018 The modification of human serum albumin through hydroxyl radical is thought to be responsible for the induction of autoantibodies against modified human serum albumin. Hydroxyl Radical 48-64 albumin Homo sapiens 32-39 28745222-5 2018 The modification of human serum albumin through hydroxyl radical is thought to be responsible for the induction of autoantibodies against modified human serum albumin. Hydroxyl Radical 48-64 albumin Homo sapiens 159-166 29237269-0 2018 Visualizing the Regulation of Hydroxyl Radical Level by Superoxide Dismutase via a Specific Molecular Probe. Hydroxyl Radical 30-46 superoxide dismutase 1 Homo sapiens 56-76 29200295-4 2018 Induced fit docking computational simulations performed on the new structures interacting with DDC highlight that for an efficient binding at the DDC site, at least one hydroxyl substituent must be present at the aromatic ring of the l-carbidopa analogues and show that the presence of fluorine can further fix the position of the ligand in the active site. Hydroxyl Radical 169-177 dopa decarboxylase Homo sapiens 95-98 29200295-4 2018 Induced fit docking computational simulations performed on the new structures interacting with DDC highlight that for an efficient binding at the DDC site, at least one hydroxyl substituent must be present at the aromatic ring of the l-carbidopa analogues and show that the presence of fluorine can further fix the position of the ligand in the active site. Hydroxyl Radical 169-177 dopa decarboxylase Homo sapiens 146-149 29133115-6 2018 With YB-1-bound RNA, nucleotides protected from attack by hydroxyl radicals were revealed in all three motifs, although hairpins with motif 2 and especially with motif 1 contained many protected nucleotides outside the motifs, suggesting that the specific environments of these motifs contribute significantly to the YB-1 binding. Hydroxyl Radical 58-75 Y-box binding protein 1 Homo sapiens 5-9 29172520-1 2017 A component of the neurotoxicity of the beta amyloid peptide (Abeta) of Alzheimer"s disease is its ability to generate superoxide, hydrogen peroxide, and hydroxyl radicals by reaction of its reduced copper complex Abeta/Cu+ with molecular oxygen. Hydroxyl Radical 154-171 amyloid beta precursor protein Homo sapiens 40-60 29317059-4 2018 This phenomenon can now be explained in terms of the modification of fibrinogen structure induced by hydroxyl radicals generated during the period of ischemia caused, in turn, by the blocking of the blood flow within the obstructed vessels. Hydroxyl Radical 101-118 fibrinogen beta chain Homo sapiens 69-79 29317059-5 2018 Fibrinogen modification involves intra-to intermolecular disulfide rearrangement induced by the reductive power of hydroxyl radicals that result in the exposition of buried hydrophobic epitopes. Hydroxyl Radical 115-132 fibrinogen beta chain Homo sapiens 0-10 29172520-1 2017 A component of the neurotoxicity of the beta amyloid peptide (Abeta) of Alzheimer"s disease is its ability to generate superoxide, hydrogen peroxide, and hydroxyl radicals by reaction of its reduced copper complex Abeta/Cu+ with molecular oxygen. Hydroxyl Radical 154-171 amyloid beta precursor protein Homo sapiens 62-67 29172520-1 2017 A component of the neurotoxicity of the beta amyloid peptide (Abeta) of Alzheimer"s disease is its ability to generate superoxide, hydrogen peroxide, and hydroxyl radicals by reaction of its reduced copper complex Abeta/Cu+ with molecular oxygen. Hydroxyl Radical 154-171 amyloid beta precursor protein Homo sapiens 214-219 29495147-12 2017 Within 2 h after PQ poisoning, the expression of TSP-1 and CD47 was positively correlated with the concentrations of ROS, hydroxyl radicals, and malondialdehyde and the degree of pulmonary alveolitis (P<0.01) ; at 1 d after PQ poisoning, the expression of TSP-1 and CD47 was positively correlated with the concentration of hydroxyproline in lung tissue (P<0.01) . Hydroxyl Radical 122-139 thrombospondin 1 Rattus norvegicus 49-54 29495147-12 2017 Within 2 h after PQ poisoning, the expression of TSP-1 and CD47 was positively correlated with the concentrations of ROS, hydroxyl radicals, and malondialdehyde and the degree of pulmonary alveolitis (P<0.01) ; at 1 d after PQ poisoning, the expression of TSP-1 and CD47 was positively correlated with the concentration of hydroxyproline in lung tissue (P<0.01) . Hydroxyl Radical 122-139 Cd47 molecule Rattus norvegicus 59-63 28474422-3 2017 RESULTS: Acacia nilotica showed significant antioxidant activity, with IC50 values of 75.157 and 159.57 microg mL-1 for 2,2-diphenyl-1-picrylhydrazyl radical and hydroxyl radical scavenging activities respectively at a concentration of 500 microg mL-1 . Hydroxyl Radical 162-178 L1 cell adhesion molecule Mus musculus 111-115 28129696-0 2017 Carboxymethylcellulose with phenolic hydroxyl microcapsules enclosinggene-modified BMSCs for controlled BMP-2 release in vitro. Hydroxyl Radical 37-45 bone morphogenetic protein 2 Rattus norvegicus 104-109 28129696-10 2017 CONCLUSIONS: Co-flow microfluidics and phenolic hydroxyl derivative of carboxymethylcellulose (CMC-Ph) provide a promising strategy for cell-enclosed microcapsules in combination with BMP-2 gene and Tet-on system modified BMSCs and then controlled BMP-2 protein released effectively as well as promoted the osteogenic differentiation of BMSCs. Hydroxyl Radical 48-56 bone morphogenetic protein 2 Rattus norvegicus 184-189 28129696-10 2017 CONCLUSIONS: Co-flow microfluidics and phenolic hydroxyl derivative of carboxymethylcellulose (CMC-Ph) provide a promising strategy for cell-enclosed microcapsules in combination with BMP-2 gene and Tet-on system modified BMSCs and then controlled BMP-2 protein released effectively as well as promoted the osteogenic differentiation of BMSCs. Hydroxyl Radical 48-56 bone morphogenetic protein 2 Rattus norvegicus 248-253 28915374-7 2017 The potential of S(-II) activating H2O2 to generate hydroxyl radicals (OH), which was confirmed by electron spin resonance (ESR) spectroscopy, quenching experiments, and trapping experiments, have supported the proposed mechanisms. Hydroxyl Radical 52-69 transcription elongation factor A1 Homo sapiens 17-22 29228015-5 2017 Cyclic voltammetric analysis revealed irreversible binding of Fe3+ to CT51, an important finding since stopping Fe2+/Fe3+ cycling in cells should prevent hydroxyl radical production resulting from the Fenton-Haber-Weiss cycle. Hydroxyl Radical 154-170 heat shock protein family B (small) member 9 Homo sapiens 70-74 29029043-4 2017 In the present study, a microbially driven Fenton reaction, previously shown to produce hydroxyl (HO ) radicals that degrade chlorinated solvents and associated solvent stabilizers, was also found to degrade source zone concentrations of the oil spill components, pyrene (10 muM) and anthracene (1 muM), at initial rates of 0.82 and 0.20 muM h -1 , respectively. Hydroxyl Radical 88-98 latexin Homo sapiens 277-280 29095609-5 2017 The results show a strong and selective inhibitory effect of TrxR, specifically for the hydroxyl-functionalized NHC gold(I) complexes (8-10). Hydroxyl Radical 88-96 peroxiredoxin 5 Homo sapiens 61-65 29095609-5 2017 The results show a strong and selective inhibitory effect of TrxR, specifically for the hydroxyl-functionalized NHC gold(I) complexes (8-10). Hydroxyl Radical 88-96 high mobility group nucleosomal binding domain 4 Homo sapiens 112-115 29077421-2 2017 These singular reactions involve selective SN2" allylic substitutions with concomitant ring opening of the cyclic carbonate and with extrusion of CO2 and formation of a useful hydroxyl functionality in a single step. Hydroxyl Radical 176-184 solute carrier family 38 member 5 Homo sapiens 43-46 29029043-4 2017 In the present study, a microbially driven Fenton reaction, previously shown to produce hydroxyl (HO ) radicals that degrade chlorinated solvents and associated solvent stabilizers, was also found to degrade source zone concentrations of the oil spill components, pyrene (10 muM) and anthracene (1 muM), at initial rates of 0.82 and 0.20 muM h -1 , respectively. Hydroxyl Radical 88-98 latexin Homo sapiens 300-303 29029043-4 2017 In the present study, a microbially driven Fenton reaction, previously shown to produce hydroxyl (HO ) radicals that degrade chlorinated solvents and associated solvent stabilizers, was also found to degrade source zone concentrations of the oil spill components, pyrene (10 muM) and anthracene (1 muM), at initial rates of 0.82 and 0.20 muM h -1 , respectively. Hydroxyl Radical 88-98 latexin Homo sapiens 300-303 29029043-4 2017 In the present study, a microbially driven Fenton reaction, previously shown to produce hydroxyl (HO ) radicals that degrade chlorinated solvents and associated solvent stabilizers, was also found to degrade source zone concentrations of the oil spill components, pyrene (10 muM) and anthracene (1 muM), at initial rates of 0.82 and 0.20 muM h -1 , respectively. Hydroxyl Radical 98-113 latexin Homo sapiens 277-280 29029043-4 2017 In the present study, a microbially driven Fenton reaction, previously shown to produce hydroxyl (HO ) radicals that degrade chlorinated solvents and associated solvent stabilizers, was also found to degrade source zone concentrations of the oil spill components, pyrene (10 muM) and anthracene (1 muM), at initial rates of 0.82 and 0.20 muM h -1 , respectively. Hydroxyl Radical 98-113 latexin Homo sapiens 300-303 29029043-4 2017 In the present study, a microbially driven Fenton reaction, previously shown to produce hydroxyl (HO ) radicals that degrade chlorinated solvents and associated solvent stabilizers, was also found to degrade source zone concentrations of the oil spill components, pyrene (10 muM) and anthracene (1 muM), at initial rates of 0.82 and 0.20 muM h -1 , respectively. Hydroxyl Radical 98-113 latexin Homo sapiens 300-303 29619206-6 2018 Especially under hypoxia, Ru2 still retained an excellent PDT effect, which can be attributed to the direct charge transfer between the excited PS and an adjacent substrate through a type I photochemical process, forming highly-oxidative hydroxyl radicals to damage tumor cells. Hydroxyl Radical 238-255 doublecortin domain containing 2a Mus musculus 26-29 28841423-5 2017 In addition to direct photolysis, BDE-209 could be oxidized by hydroxyl radicals generated from SG, as confirmed by the electron paramagnetic resonance (EPR) technology. Hydroxyl Radical 63-80 homeobox D13 Homo sapiens 34-37 28803055-7 2017 The hydroxyl (AA-OH) and chloro (AA-Cl) derivatives acted as inhibitors of LAAO but did not interact with DNA. Hydroxyl Radical 4-12 interleukin 4 induced 1 Homo sapiens 75-79 28780636-5 2017 It was demonstrated that the acidic conditions promoted the photoconversion of CN-2 by the active groups such as superoxide radical anion, hydrogen peroxide and hydroxyl radical produced in the system. Hydroxyl Radical 161-177 carnosine dipeptidase 2 Homo sapiens 79-83 28799606-4 2017 It is proposed that Cu2+ binds with the imine and hydroxyl moiety of 1 in 1 : 2 binding stoichiometry, thereby enhancing the fluorescence at 386 nm. Hydroxyl Radical 50-58 immunoglobulin kappa variable 1-35 Mus musculus 20-23 29158850-6 2017 It induced G1-phase cell cycle arrest and apoptosis through the regulation of cell cycle- and apoptosis-regulating genes by directly binding to the hydroxyl residue of threonine 456 in the DBD of STAT3. Hydroxyl Radical 148-156 signal transducer and activator of transcription 3 Homo sapiens 196-201 28790174-5 2017 Hydroxyl radical DNA footprinting indicated that the site-specifically bound PU.1 dimers occupied an extended DNA interface downstream from the 5"-GGAA-3" core consensus relative to its 1:1 counterpart, thus explaining the apparent site size requirement for sequential dimerization. Hydroxyl Radical 0-16 Spi-1 proto-oncogene Homo sapiens 77-81 28109135-9 2017 However, model scenarios suggest that hydroxyl radical degradation may significantly contribute to the degradation of more polar DBT and C1-DBT at 1-m and 2-m depths. Hydroxyl Radical 38-54 heterogeneous nuclear ribonucleoprotein C Homo sapiens 137-148 31957295-3 2017 Herein, a SnS2 -modified porous beta-cyclodextrin-containing polymer (SnS2 @PCDP), which was derived by nucleophilic aromatic substitution of the hydroxyl groups of both beta-CD and SnS2 -OH by tetrafluoroterephthalonitrile, was prepared for the rapid, complete removal of organic pollutants from water . Hydroxyl Radical 146-154 sodium voltage-gated channel alpha subunit 11 Homo sapiens 10-14 31957295-3 2017 Herein, a SnS2 -modified porous beta-cyclodextrin-containing polymer (SnS2 @PCDP), which was derived by nucleophilic aromatic substitution of the hydroxyl groups of both beta-CD and SnS2 -OH by tetrafluoroterephthalonitrile, was prepared for the rapid, complete removal of organic pollutants from water . Hydroxyl Radical 146-154 sodium voltage-gated channel alpha subunit 11 Homo sapiens 70-74 31957295-3 2017 Herein, a SnS2 -modified porous beta-cyclodextrin-containing polymer (SnS2 @PCDP), which was derived by nucleophilic aromatic substitution of the hydroxyl groups of both beta-CD and SnS2 -OH by tetrafluoroterephthalonitrile, was prepared for the rapid, complete removal of organic pollutants from water . Hydroxyl Radical 146-154 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 170-177 31957295-3 2017 Herein, a SnS2 -modified porous beta-cyclodextrin-containing polymer (SnS2 @PCDP), which was derived by nucleophilic aromatic substitution of the hydroxyl groups of both beta-CD and SnS2 -OH by tetrafluoroterephthalonitrile, was prepared for the rapid, complete removal of organic pollutants from water . Hydroxyl Radical 146-154 sodium voltage-gated channel alpha subunit 11 Homo sapiens 70-74 28585973-4 2017 Once emitted, BVOCs are rapidly oxidised by O3, and the hydroxyl (OH) and nitrate (NO3) radicals. Hydroxyl Radical 56-64 NBL1, DAN family BMP antagonist Homo sapiens 83-86 28587825-4 2017 Modification of C-3 hydroxyl with size-limited groups did not reduce the activity obviously. Hydroxyl Radical 20-28 complement C3 Homo sapiens 16-19 28595002-4 2017 Using recombinant human enzyme, we discovered that DCXR mediates redox cycling of a variety of quinones generating superoxide anion, hydrogen peroxide, and, in the presence of transition metals, hydroxyl radicals. Hydroxyl Radical 195-212 dicarbonyl and L-xylulose reductase Homo sapiens 51-55 28344090-6 2017 DCP-2 had stronger antioxidant activity against DPPH, hydroxyl, superoxide anion and ABTS radical, while DCP-1 had hardly any antioxidant activity and DCP had weaker antioxidant activity. Hydroxyl Radical 54-62 decapping mRNA 2 Mus musculus 0-5 28590715-3 2017 Recently, studies have indicated that the activation of NLRP3 inflammasome plays a critical role in inducing adjuvant effects that are controlled by the inherent shape and hydroxyl contents of aluminum oxyhydroxide (AlOOH) nanoparticles; however, the detailed relationship between surface properties and adjuvant effects for these materials remains unknown. Hydroxyl Radical 172-180 NLR family, pyrin domain containing 3 Mus musculus 56-61 28742114-4 2017 Results showed that EP-1 possessed higher oxygen radical absorbance capacity (ORAC) and 2-3 times higher ability to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH), superoxide and hydroxyl radicals than a hot water extract of commercially available HE fruiting body. Hydroxyl Radical 178-195 prostaglandin E receptor 1 Homo sapiens 20-24 28482099-3 2017 Here, directed hydroxyl radical probing and single particle cryo-EM are employed to elucidate RsgA"s mechanism of action. Hydroxyl Radical 15-31 zinc finger protein 24 Homo sapiens 94-98 28452222-3 2017 Here, we further optimized an ultrafast laser photolysis hydroxyl radical footprinting method and applied it to study the interaction of EGF and EGFR in live mammalian cells. Hydroxyl Radical 57-73 epidermal growth factor Homo sapiens 137-140 28452222-3 2017 Here, we further optimized an ultrafast laser photolysis hydroxyl radical footprinting method and applied it to study the interaction of EGF and EGFR in live mammalian cells. Hydroxyl Radical 57-73 epidermal growth factor receptor Homo sapiens 145-149 28532624-10 2017 We previously reported that AG-related compounds blocked H2O2-induced TRPM2 activation by scavenging the hydroxyl radical. Hydroxyl Radical 105-121 transient receptor potential cation channel subfamily M member 2 Homo sapiens 70-75 28174084-3 2017 In order to assess the antioxidant activities of MP-1, four kinds of methods were used, including scavenging hydroxyl radical, DPPH, superoxide anion radical, and FRAP, and the results indicated high antioxidant activities. Hydroxyl Radical 109-125 pitrilysin metallopeptidase 1 Homo sapiens 49-53 28566709-5 2017 In this work, we show that the C-At "organometalloid" bond can be cleaved by oxidative dehalogenation induced by oxidants such as permanganates, peroxides or hydroxyl radicals. Hydroxyl Radical 158-175 catalase Homo sapiens 31-35 28532624-4 2017 We recently reported that some Tyrphostin AG-related compounds inhibited the H2O2-induced activation of TRPM2 by scavenging the intracellular hydroxyl radical. Hydroxyl Radical 142-158 transient receptor potential cation channel subfamily M member 2 Homo sapiens 104-109 28363579-2 2017 A successful homogeneous coating of PEDOT:PSS on cellulose nanofibers occurred by means hydrogen-bonding interactions between the hydroxyl functionalized CNF and the electronically charged PEDOT:PSS, as shown by FTIR spectra. Hydroxyl Radical 130-138 NPHS1 adhesion molecule, nephrin Homo sapiens 154-157 28532624-11 2017 The inhibitory effects of AG-related compounds on TRPM2-independent responses may be due to scavenging of the hydroxyl radical. Hydroxyl Radical 110-126 transient receptor potential cation channel subfamily M member 2 Homo sapiens 50-55 28507700-6 2017 A proof-of-concept study was conducted on a hydroxyl-decorated porous material MFM-300(VIII) under (i) five different CO2 pressures covering the isotherm range and (ii) the loading of equimolar mixtures of CO2/N2. Hydroxyl Radical 44-52 cytochrome c oxidase subunit 8A Homo sapiens 87-91 28340298-1 2017 Photolysis of nitrate (NO3-) produces reactive nitrogen and oxygen species via three different channels, forming: (1) nitrogen dioxide (NO2) and hydroxyl radical ( OH), (2) nitrite (NO2-) and oxygen atom (O(3P)), and (3) peroxynitrite (ONOO-). Hydroxyl Radical 145-161 NBL1, DAN family BMP antagonist Homo sapiens 23-26 27878158-4 2017 When the natural photosensitizers were added, the amount of phosphate released increased significantly because of the diazinon indirect photodegradation by reactive species, such as the hydroxyl radical generated by NO3- and Fe3+. Hydroxyl Radical 186-202 NBL1, DAN family BMP antagonist Homo sapiens 216-219 28362454-4 2017 4Me-BO-An-O was subjected to react with various reactive oxygen/nitrogen species (ROS/RNS) and selective fluorescence turn-on detection of a hydroxyl radical was achieved, validating the concept of "using stable radicals to detect ROS/RNS". Hydroxyl Radical 141-157 FAM20C golgi associated secretory pathway kinase Homo sapiens 86-89 28362454-4 2017 4Me-BO-An-O was subjected to react with various reactive oxygen/nitrogen species (ROS/RNS) and selective fluorescence turn-on detection of a hydroxyl radical was achieved, validating the concept of "using stable radicals to detect ROS/RNS". Hydroxyl Radical 141-157 FAM20C golgi associated secretory pathway kinase Homo sapiens 235-238 27973724-10 2017 AC-4 and ACALK possess ability to scavenge DPPH, ABTS radicals and effectively protected plasmid pBR322 DNA from damage caused by hydroxyl radicals. Hydroxyl Radical 130-147 adenylate cyclase 4 Homo sapiens 0-4 28199110-1 2017 Rate coefficients of H atom abstraction and H atom addition reactions of 3-hexene by the hydroxyl radicals were determined using both conventional transition-state theory and canonical variational transition-state theory, with the potential energy surface (PES) evaluated at the CCSD(T)/CBS//BHandHLYP/6-311G(d,p) level and quantum mechanical effect corrected by the compounded methods including one-dimensional Wigner method, multidimensional zero-curvature tunneling method, and small-curvature tunneling method. Hydroxyl Radical 89-106 cystathionine beta-synthase Homo sapiens 287-290 28327537-7 2017 MP2MDCS and MP4MDCS with more than 90% scavenging indices both had great scavenging ability on hydroxyl radicals or DPPH radicals. Hydroxyl Radical 95-112 tryptase pseudogene 1 Homo sapiens 0-3 28159367-5 2017 In this study, we determined the critical conditions of PC on PGC using CHCl3/dichlorobenzene (DCB) and CHCl3/trichlorobenzene (TCB) as eluents achieving separations according to hydroxyl end-groups, which was confirmed by MALDI-TOF-MS analysis. Hydroxyl Radical 179-187 pyruvate kinase M1/2 Homo sapiens 104-132 27785693-6 2017 The screening strategy involves the diagnostic neutral loss of hydroxyl radical triggering MS3 fragmentation, which is only observed in positive ionization mode of DNPH-derivatized carbonyls. Hydroxyl Radical 63-79 MS3 Homo sapiens 91-94 28331320-3 2017 This work explored the use of a neutral, non-cytotoxic hydroxyl-terminated poly(amidoamine) (PAMAM-OH) dendrimer as an Ang-(1-7) carrier. Hydroxyl Radical 55-63 angiogenin, ribonuclease, RNase A family, 5 Mus musculus 119-127 28109789-1 2017 To enhance aldose reductase (ALR2) inhibition and add antioxidant ability, phenolic hydroxyl was introduced both to the quinoxalinone core and C3 side chain, resulting in a series of derivatives as ALR2 inhibitors. Hydroxyl Radical 84-92 aldo-keto reductase family 1 member B Homo sapiens 11-27 30108813-3 2017 The chirality of the carbon bearing the C2 substituent, as well as the position of the hydroxyl (tolerated at C5, but not at C3) has profound influence on the inhibitory activity of both DAGLalpha and ABHD6, as established using biochemical assays and competitive activity-based protein profiling on mouse brain extracts. Hydroxyl Radical 87-95 diacylglycerol lipase, alpha Mus musculus 187-196 30108813-3 2017 The chirality of the carbon bearing the C2 substituent, as well as the position of the hydroxyl (tolerated at C5, but not at C3) has profound influence on the inhibitory activity of both DAGLalpha and ABHD6, as established using biochemical assays and competitive activity-based protein profiling on mouse brain extracts. Hydroxyl Radical 87-95 abhydrolase domain containing 6 Mus musculus 201-206 28161087-6 2017 In vitro antioxidant activity assay proved that LEP-2a possessed significant scavenging activities on superoxide, hydroxyl and DPPH radical. Hydroxyl Radical 114-122 late cornified envelope 1B Homo sapiens 48-53 28102671-4 2017 Here, the interaction of full-length, glycosylated gp120 with bNAb b12 is probed using high-resolution hydroxyl radical protein footprinting (HR-HRPF) by fast photochemical oxidation of proteins. Hydroxyl Radical 103-111 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 51-56 28150831-0 2017 MicroRNA-mediated silence of onco-lncRNA MALAT1 in different ESCC cells via ligand-functionalized hydroxyl-rich nanovectors. Hydroxyl Radical 98-106 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 41-47 28109789-1 2017 To enhance aldose reductase (ALR2) inhibition and add antioxidant ability, phenolic hydroxyl was introduced both to the quinoxalinone core and C3 side chain, resulting in a series of derivatives as ALR2 inhibitors. Hydroxyl Radical 84-92 aldo-keto reductase family 1 member B Homo sapiens 29-33 28109789-1 2017 To enhance aldose reductase (ALR2) inhibition and add antioxidant ability, phenolic hydroxyl was introduced both to the quinoxalinone core and C3 side chain, resulting in a series of derivatives as ALR2 inhibitors. Hydroxyl Radical 84-92 aldo-keto reductase family 1 member B Homo sapiens 198-202 28109789-4 2017 Structure-activity relationship and docking studies highlighted the importance of phenolic hydroxyl both in C3 side chain and the core structure for constructing potent ALR2 inhibitors with antioxidant activity. Hydroxyl Radical 91-99 aldo-keto reductase family 1 member B Homo sapiens 169-173 28058415-3 2017 In contrast to bilayers and multilayers, the trilayer structure appears to grow pseudomorphic with the Au(111) substrate, and in addition we reveal the presence of a hydroxyl overlayer on this island type as evidenced by the appearance of a superstructure in STM correlated with the fingerprints of OH species in XPS and valence band spectroscopy. Hydroxyl Radical 166-174 sulfotransferase family 1A member 3 Homo sapiens 259-262 27837168-2 2017 The structure-dependent AhR activity of hydroxyl/carboxy-substituted naphthoic acids (NAs) was determined in young adult mouse colonic (YAMC) cells and human Caco2 colon cancer cells using CYP1A1/CYP1B1 mRNAs as Ah-responsive genes. Hydroxyl Radical 40-48 aryl-hydrocarbon receptor Mus musculus 24-27 27837168-2 2017 The structure-dependent AhR activity of hydroxyl/carboxy-substituted naphthoic acids (NAs) was determined in young adult mouse colonic (YAMC) cells and human Caco2 colon cancer cells using CYP1A1/CYP1B1 mRNAs as Ah-responsive genes. Hydroxyl Radical 40-48 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 189-195 27837168-2 2017 The structure-dependent AhR activity of hydroxyl/carboxy-substituted naphthoic acids (NAs) was determined in young adult mouse colonic (YAMC) cells and human Caco2 colon cancer cells using CYP1A1/CYP1B1 mRNAs as Ah-responsive genes. Hydroxyl Radical 40-48 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 196-202 27837168-4 2017 1,4-DHNA was the most potent compound among hydroxyl/carboxy naphthalene derivatives, and the fold induction response for CYP1A1 and CYP1B1 was similar to that observed for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in YAMC and Caco2 cells. Hydroxyl Radical 44-52 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 122-128 27837168-4 2017 1,4-DHNA was the most potent compound among hydroxyl/carboxy naphthalene derivatives, and the fold induction response for CYP1A1 and CYP1B1 was similar to that observed for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in YAMC and Caco2 cells. Hydroxyl Radical 44-52 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 133-139 27928907-0 2017 Separation of HIV-1 gag virus-like particles from vesicular particles impurities by hydroxyl-functionalized monoliths. Hydroxyl Radical 84-92 Pr55(Gag) Human immunodeficiency virus 1 20-23 27928907-2 2017 We used hydroxyl-functionalized polymethacrylate monoliths, providing hydrophobic and electrostatic binding contributions, for the purification of HIV-1 gag virus-like particles. Hydroxyl Radical 8-16 Pr55(Gag) Human immunodeficiency virus 1 153-156 28326165-2 2017 Reduced expression of aldehyde dehydrogenase-1 (ALDH1) and glutathione peroxidase-1 (GPX1), enzymes that function to detoxify aldehydes and hydroxyl radicals, respectively, has been reported in the substantia nigra of patients who died with PD. Hydroxyl Radical 140-157 aldehyde dehydrogenase 1 family member A1 Homo sapiens 22-46 27776865-7 2017 The results also demonstrated that at a higher content of Fe-SOM, more hydroxyl radical (OH) was produced in the solid phase and more TPH was degraded. Hydroxyl Radical 71-87 grainyhead like transcription factor 3 Homo sapiens 58-64 28326165-2 2017 Reduced expression of aldehyde dehydrogenase-1 (ALDH1) and glutathione peroxidase-1 (GPX1), enzymes that function to detoxify aldehydes and hydroxyl radicals, respectively, has been reported in the substantia nigra of patients who died with PD. Hydroxyl Radical 140-157 aldehyde dehydrogenase 1 family member A1 Homo sapiens 48-53 28326165-2 2017 Reduced expression of aldehyde dehydrogenase-1 (ALDH1) and glutathione peroxidase-1 (GPX1), enzymes that function to detoxify aldehydes and hydroxyl radicals, respectively, has been reported in the substantia nigra of patients who died with PD. Hydroxyl Radical 140-157 glutathione peroxidase 1 Homo sapiens 59-83 28326165-2 2017 Reduced expression of aldehyde dehydrogenase-1 (ALDH1) and glutathione peroxidase-1 (GPX1), enzymes that function to detoxify aldehydes and hydroxyl radicals, respectively, has been reported in the substantia nigra of patients who died with PD. Hydroxyl Radical 140-157 glutathione peroxidase 1 Homo sapiens 85-89 27387282-5 2016 Here, directed hydroxyl radical probing showed that KH1 also binds near the cadicivirus tetraloop. Hydroxyl Radical 15-31 potassium voltage-gated channel modifier subfamily F member 1 Homo sapiens 52-55 27519319-7 2017 Moreover, according to the main intermediate products identified by gas chromatography-mass spectrometry (GC-MS), a possible pathway of p-NP degradation was proposed based on hydrogen radicals ([H]) or hydroxyl radicals ( OH) mechanism. Hydroxyl Radical 202-219 purine nucleoside phosphorylase Homo sapiens 136-140 27908452-7 2017 Experiments with glycine also showed that NO3- was formed via an intermediate with a second-order rate constant of 7.7 +- 0.1 M-1s-1 while NH4+ was formed by an electron-transfer mechanism with O3 as confirmed from a hydroxyl radical (OH) yield of 24.7 +- 1.9%. Hydroxyl Radical 217-233 NBL1, DAN family BMP antagonist Homo sapiens 42-45 27868112-8 2016 Similarly to oxidations mediated by certain LPMOs, thorough MS/MS-analysis of selected products and comparison with synthesised standards confirmed two types of glycosidic cleavage cascades induced by HO -mediated H-atom abstraction at C1 and C3/C4, producing gluconic acids, native oligosaccharides, and oxo-oligomers (carbonyl at non-reducing end). Hydroxyl Radical 201-203 heterogeneous nuclear ribonucleoprotein C Homo sapiens 236-248 28243358-3 2017 HW specifically decreased hydroxyl radical ( OH) levels in the c-kit+ cells of 4 Gy irradiated mice. Hydroxyl Radical 26-42 KIT proto-oncogene receptor tyrosine kinase Mus musculus 63-68 28082995-6 2016 Bcl-2 21 scavenged approximately 50% hydroxyl radical (HO ) formed, whereas Ac-DEVD-CHO scavenged approximately 20% of HO . Hydroxyl Radical 37-53 BCL2 apoptosis regulator Homo sapiens 0-5 28082995-6 2016 Bcl-2 21 scavenged approximately 50% hydroxyl radical (HO ) formed, whereas Ac-DEVD-CHO scavenged approximately 20% of HO . Hydroxyl Radical 55-57 BCL2 apoptosis regulator Homo sapiens 0-5 27993063-2 2016 Here we show that Ag2SNPs can release tiny amounts of silver ion via cation exchange reactions between Ag(I) and Fe(III) in the dark, while in the light dramatic dissolution of Ag2SNP occurs, which is mainly attributed to the Ag2SNP oxidation by the hydroxyl radical formed during the reduction of Fe(III) to Fe(II) in water under sunlit conditions. Hydroxyl Radical 250-266 anterior gradient 2, protein disulphide isomerase family member Homo sapiens 18-21 27812111-7 2016 The AMSNPs-MOR have good antioxidant properties by itself and exhibit a synergic effect with morin on the antioxidant property against hydroxyl radical. Hydroxyl Radical 135-151 opioid receptor mu 1 Homo sapiens 11-14 27782412-1 2016 The thermal decomposition of syn-ethanal-oxide (syn-CH3CHOO) through vinyl hydrogen peroxide (VHP) leading to hydroxyl radical is characterized using a modification of the HEAT thermochemical protocol. Hydroxyl Radical 110-126 synemin Homo sapiens 29-32 27715014-0 2016 Ratiometric Fluorescent Biosensing of Hydrogen Peroxide and Hydroxyl Radical in Living Cells with Lysozyme-Silver Nanoclusters: Lysozyme as Stabilizing Ligand and Fluorescence Signal Unit. Hydroxyl Radical 60-76 lysozyme Homo sapiens 98-106 27173532-2 2016 Superoxide radicals (O2(*-)) and their protonated form (hydroperoxyl radicals, HO2(*)) were detected by the reduction of nitroblue tetrazolium into formazan, and hydroxyl radicals (OH(*)) were detected by the hydroxylation of terephthalate. Hydroxyl Radical 162-179 heme oxygenase 2 Homo sapiens 79-82 27782412-1 2016 The thermal decomposition of syn-ethanal-oxide (syn-CH3CHOO) through vinyl hydrogen peroxide (VHP) leading to hydroxyl radical is characterized using a modification of the HEAT thermochemical protocol. Hydroxyl Radical 110-126 synemin Homo sapiens 48-51 26818028-1 2016 The aim of this study was to prepare a model protein, bovine serum albumin (BSA) loaded double-walled microspheres using a fast degrading glucose core, hydroxyl-terminated poly(lactide-co-glycolide) (Glu-PLGA) and a moderate-degrading carboxyl-terminated PLGA polymers to reduce the initial burst release and to eliminate the lag phase from the release profile of PLGA microspheres. Hydroxyl Radical 152-160 albumin Homo sapiens 61-74 27521615-4 2016 Therefore, the overall aim of this project was to utilize iron oxide nanoparticles conjugated to a cell penetrating peptide, TAT, to escape lysosomal encapsulation after internalization by cancer cells and catalyze hydroxyl radical formation. Hydroxyl Radical 215-231 tyrosine aminotransferase Homo sapiens 125-128 27694528-6 2016 Moreover, C10-OH/C8-DC and total hydroxyl-/dicarboxyl-acylcarnitine levels tended to be negatively associated with the serum insulin level, and the total hydroxyl-/dicarboxyl-acylcarnitine level additionally tended to be negatively associated with the hepatic insulin resistance index. Hydroxyl Radical 33-43 insulin Homo sapiens 125-132 27694528-6 2016 Moreover, C10-OH/C8-DC and total hydroxyl-/dicarboxyl-acylcarnitine levels tended to be negatively associated with the serum insulin level, and the total hydroxyl-/dicarboxyl-acylcarnitine level additionally tended to be negatively associated with the hepatic insulin resistance index. Hydroxyl Radical 154-164 homeobox C10 Homo sapiens 10-13 27238971-3 2016 We recently reported that Tyrphostin AG490 exerted inhibitory effects on H2O2-induced TRPM2 activation by scavenging the hydroxyl radical. Hydroxyl Radical 121-137 transient receptor potential cation channel subfamily M member 2 Homo sapiens 86-91 27325408-2 2016 Glycated Cu,Zn-SOD produces hydroxyl radicals in the presence of transition metals due to the formation of a Schiff base adduct and a subsequent Amadori product. Hydroxyl Radical 28-45 superoxide dismutase 1 Homo sapiens 9-18 27448725-7 2016 However, the observed more successful acclimation required less activation of peroxidases in the doubly transformed plants than in the wild type and less increase in non-enzymatic hydroxyl radical neutralization in the dehydroascorbate reductase plus glutathione reductase fortified plants than in either of the other lines. Hydroxyl Radical 180-196 glutathione S-transferase DHAR2-like Nicotiana tabacum 219-245 26988468-5 2016 Apo-transferrin increased the formation of hydroxyl radicals and this related with a faster degradation of beta-glucan. Hydroxyl Radical 43-60 transferrin Homo sapiens 4-15 27298338-8 2016 In the current study, we highlight the role of aldehyde oxidase in the formation of the hydroxyl-metabolite of VX-509, which is involved in clinically significant TDI-based DDIs and represents an additional example in which a system-dependent prediction of TDI would be evident. Hydroxyl Radical 88-96 aldehyde oxidase 1 Homo sapiens 47-63 26549031-5 2016 The hydroxyl radical, which is produced in a Fenton reaction catalyzed by an iron ion, serves as a potent DNA-DSB-inducing molecule, raising the potential of an iron ion transporter of transferrin in the formation of DNA-DSBs. Hydroxyl Radical 4-20 transferrin Homo sapiens 185-196 27394172-7 2016 Consequently, our data signifies that EC-SOD released from activated neutrophils affects the redox conditions of the extracellular space and may offer protection against highly reactive oxygen species such as hydroxyl radicals otherwise generated as a result of respiratory burst activity of activated neutrophils. Hydroxyl Radical 209-226 superoxide dismutase 3 Homo sapiens 38-44 27928516-2 2016 We determined the reducing power of PSO and its scavenging effects on hydroxyl ( OH) and 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH ) and tested its stabilizing effects on horse oil storage. Hydroxyl Radical 70-78 pipecolic acid and sarcosine oxidase Homo sapiens 36-39 27099340-0 2016 Probing the solution structure of Factor H using hydroxyl radical protein footprinting and cross-linking. Hydroxyl Radical 49-65 complement factor H Homo sapiens 34-42 26953687-0 2016 Monoamine oxidase-induced hydroxyl radical production and cardiomyocyte injury during myocardial ischemia-reperfusion in rats. Hydroxyl Radical 26-42 monoamine oxidase A Rattus norvegicus 0-17 26953687-1 2016 To elucidate the involvement of monoamine oxidase (MAO) in hydroxyl radical production and cardiomyocyte injury during ischemia as well as after reperfusion, we applied microdialysis technique to the heart of anesthetized rats. Hydroxyl Radical 59-75 monoamine oxidase A Rattus norvegicus 32-49 26953687-1 2016 To elucidate the involvement of monoamine oxidase (MAO) in hydroxyl radical production and cardiomyocyte injury during ischemia as well as after reperfusion, we applied microdialysis technique to the heart of anesthetized rats. Hydroxyl Radical 59-75 monoamine oxidase A Rattus norvegicus 51-54 26953687-11 2016 MAO plays a significant role in hydroxyl radical production and cardiomyocyte injury during ischemia as well as after reperfusion. Hydroxyl Radical 32-48 monoamine oxidase A Rattus norvegicus 0-3 27080180-5 2016 Thus, lobelane analogues bearing hydroxyl and fluoroethoxy moieties retain the high affinity for VMAT2 of the parent compound, while enhancing selectivity for VMAT2 versus the plasmalemma transporters. Hydroxyl Radical 33-41 solute carrier family 18 member A2 Homo sapiens 97-102 27018067-6 2016 In addition, the increased production of ROS such as superoxide and hydroxyl radical by PM exposure increases MMPs including MMP-1, MMP-2, and MMP-9, resulting in the degradation of collagen. Hydroxyl Radical 68-84 matrix metallopeptidase 1 Homo sapiens 110-114 26911281-7 2016 Instead, the sex-determining region Y (SRY)-box 9 protein (SOX9) was substantially linked to iron treatment and hydroxyl radical level. Hydroxyl Radical 112-128 SRY-box transcription factor 9 Homo sapiens 59-63 27018067-6 2016 In addition, the increased production of ROS such as superoxide and hydroxyl radical by PM exposure increases MMPs including MMP-1, MMP-2, and MMP-9, resulting in the degradation of collagen. Hydroxyl Radical 68-84 matrix metallopeptidase 1 Homo sapiens 125-130 27018067-6 2016 In addition, the increased production of ROS such as superoxide and hydroxyl radical by PM exposure increases MMPs including MMP-1, MMP-2, and MMP-9, resulting in the degradation of collagen. Hydroxyl Radical 68-84 matrix metallopeptidase 2 Homo sapiens 132-137 27018067-6 2016 In addition, the increased production of ROS such as superoxide and hydroxyl radical by PM exposure increases MMPs including MMP-1, MMP-2, and MMP-9, resulting in the degradation of collagen. Hydroxyl Radical 68-84 matrix metallopeptidase 9 Homo sapiens 143-148 28955884-7 2016 The anti-oxidant capacity of CT-treated rHSA was quantified by its ability to scavenge peroxynitrite and the hydroxyl radical. Hydroxyl Radical 109-125 CD24 molecule Rattus norvegicus 40-44 26938666-4 2016 Interference by the nucleobase is minimized by the use of indium(III) triflate as the donor activating reagent; the In(OTf)3 serves to promote apparent transfer of the donor glycosyl moiety from nucleobase to hydroxyl. Hydroxyl Radical 209-217 POU class 5 homeobox 1 Homo sapiens 119-124 26948406-6 2016 H2O2 can permeate into the nanosphere and react with ferrocene to product hydroxyl radical ( OH) via Fenton reaction, which cleaves FDNA to detach ROX from PTAD, thus in turn, lights the ROX fluorescence. Hydroxyl Radical 74-90 max binding protein Mus musculus 147-150 26948406-6 2016 H2O2 can permeate into the nanosphere and react with ferrocene to product hydroxyl radical ( OH) via Fenton reaction, which cleaves FDNA to detach ROX from PTAD, thus in turn, lights the ROX fluorescence. Hydroxyl Radical 74-90 max binding protein Mus musculus 187-190 26896706-10 2016 The active hydroxyl metabolite was detected after incubation in HLM and hHEP, implicating the involvement of other enzymes in its metabolism. Hydroxyl Radical 11-19 EPH receptor B6 Homo sapiens 72-76 26976974-3 2016 Since D3 analogs with two symmetric side chains (Gemini analogs) result in potent activation of the vitamin D receptor (VDR), we hypothesized that the chain length and composition of these types of analogs also containing a 20-hydroxyl group would affect their biological activities. Hydroxyl Radical 227-235 vitamin D receptor Homo sapiens 120-123 26865334-7 2016 Hydroxyl radical-induced DNA injury was followed by the activation of poly(ADP-ribose) polymerase-1, depletion of NAD(+) and ATP, and elevations in intracellular Ca(2+). Hydroxyl Radical 0-16 poly(ADP-ribose) polymerase 1 Homo sapiens 70-99 26657039-9 2016 Deleterious mutations have been shown to modify SOD1 activity, which leads to the accumulation of highly toxic hydroxyl radicals. Hydroxyl Radical 111-128 superoxide dismutase 1 Homo sapiens 48-52 26892525-0 2016 A novel DPP-4 inhibitor teneligliptin scavenges hydroxyl radicals: In vitro study evaluated by electron spin resonance spectroscopy and in vivo study using DPP-4 deficient rats. Hydroxyl Radical 48-65 dipeptidylpeptidase 4 Rattus norvegicus 8-13 26892525-3 2016 Here we show that the structure of teneligliptin, a novel DPP-4 inhibitor, has a scavenging activity on hydroxyl radical ( OH). Hydroxyl Radical 104-120 dipeptidylpeptidase 4 Rattus norvegicus 58-63 26786694-5 2016 In addition, compound 13d, having potent hydroxyl radical-scavenging activity, showed more potent suppressive effect on substance P-induced pruritus in mice than oxatomide. Hydroxyl Radical 41-57 tachykinin 1 Mus musculus 120-131 26467568-6 2016 The FTIR spectra of the E. pisciphila mycelia were similar for both 0 and 2.5 microg mL-1 tricyclazole treatments, which showed hydroxyl, amine, carboxyl and phosphate groups. Hydroxyl Radical 128-136 L1 cell adhesion molecule Mus musculus 85-89 26195431-6 2016 The experimental results indicate that hydroxyl radicals oxidize cyanide to OCN(-), NO2(-), NO3(-), HCO3(-), and CO3(2-), which have lower toxicity than cyanide. Hydroxyl Radical 39-56 bone gamma-carboxyglutamate protein Homo sapiens 76-79 26729717-7 2016 Finally, we have determined the selectivity of Bdh1p toward the oxidation/reduction of the hydroxyl/ketone groups from (2R,3R)-2,3-pentanediol/2,3-pentanedione and (2R,3R)-2,3-hexanediol/2,3-hexanedione. Hydroxyl Radical 91-99 (R,R)-butanediol dehydrogenase Saccharomyces cerevisiae S288C 47-52 26653077-1 2016 Recently we presented structure-reactivity correlations for the gas-phase ambient-temperature rate constants for hydrogen abstraction from sp(3)-hybridized carbon by chlorine atom and hydroxyl radical (Cl /HO + HCR3 HCl/HOH + CR3); the reaction enthalpy effect was represented by the independent variable DeltarH and the "polar effect" by the independent variables F and R, the Hammett constants for field/inductive and resonance effects. Hydroxyl Radical 184-200 teratocarcinoma-derived growth factor 1 pseudogene 3 Homo sapiens 213-216 26626533-4 2016 As a result, the formed cationic S-TNT favours adsorption of hydroxide ions (OH(-)(ads)) and thus captures the photo-induced holes to form hydroxyl radicals ( OH). Hydroxyl Radical 139-156 chromosome 16 open reading frame 82 Homo sapiens 35-38 26646468-4 2015 The molecular oxygen activation process could generate superoxide anions to accelerate the Fe(II)/Fe(III) cycle on the syn-FeS2 surface, which favored the H2O2 decomposition to generate more hydroxyl radicals for the alachlor oxidation. Hydroxyl Radical 191-208 synemin Homo sapiens 119-122 26330107-9 2016 Two hydroxyl metabolites, that is M1 and M2, were produced from the human liver microsomal incubations (K(m) and V(max) values were 2.46 microM and 85.1 pmol/min/mg protein for M1 and 9.98 microM and 32.1 pmol/min/mg protein for M2, respectively). Hydroxyl Radical 4-12 myoregulin Homo sapiens 177-185 27293957-4 2016 In turn, IRP1 activation results in iron accumulation and hydroxyl radical-mediated damage. Hydroxyl Radical 58-74 aconitase 1 Homo sapiens 9-13 26646468-5 2015 It was found that the hydroxyl radicals generation rate constant of syn-FeS2 Fenton system was 71 times that of its com-FeS2 counterpart, and even 1-3 orders of magnitude larger than those of commonly used Fe-bearing heterogeneous catalysts. Hydroxyl Radical 22-39 synemin Homo sapiens 68-71 26432959-2 2015 Herein, we have reported the interaction of three different biological macromolecules such as hemoglobin, gamma globulin and transferrin with hydroxyl group functionalized Multi-Walled Carbon Nanotubes (OH-MWCNTs). Hydroxyl Radical 142-150 transferrin Homo sapiens 125-136 26456176-7 2015 Also, we found that the in vitro reaction between PPD and H2O2, even below the maximum allowance by cosmetic industries, released hydroxyl radicals which can damage DNA. Hydroxyl Radical 130-147 4-hydroxyphenylpyruvate dioxygenase Homo sapiens 50-53 26247837-5 2015 Under oxidative and nitrative stress conditions, the Abeta-Cu(II) complex caused oxidation and nitration of the Abeta Tyr 10 residue through peroxidase-like reactions, where the formation of Cu(I) and hydroxyl radical (OH) was proposed as a chemical mechanism. Hydroxyl Radical 201-217 amyloid beta precursor protein Homo sapiens 53-58 26399297-4 2015 Analyses of the main interactions in the active site of DPP-4, in particular, the contribution of the hydroxyl coordination between Tyr547 and Ser630 by the water molecule, which is described in the literature as important for the coordinated interactions in the active site, were performed. Hydroxyl Radical 102-110 dipeptidyl peptidase 4 Homo sapiens 56-61 26148434-0 2015 Hydroxyl metabolite of PCB 180 induces DNA damage signaling and enhances the DNA damaging effect of benzo[a]pyrene. Hydroxyl Radical 0-8 pyruvate carboxylase Rattus norvegicus 23-26 26289753-8 2015 Similarly, preincubation with the hydroxyl radical scavenger dimethyl sulfoxide (DMSO) resulted in the enhanced presence of DMT1 at the apical membrane. Hydroxyl Radical 34-50 solute carrier family 11 member 2 Homo sapiens 124-128 26362234-0 2015 Immuno-chemistry of hydroxyl radical modified GAD-65: A possible role in experimental and human diabetes mellitus. Hydroxyl Radical 20-36 glutamate decarboxylase 2 Homo sapiens 46-52 26362234-5 2015 In the present study, GAD-65 was modified by hydroxyl radical following Fenton"s reaction. Hydroxyl Radical 45-61 glutamate decarboxylase 2 Homo sapiens 22-28 26362234-7 2015 Immunogenicity of both native and hydroxyl radical modified GAD-65 (ROS-GAD-65) was studied in experimental rabbits and was confirmed by inducing type I diabetes in experimental male albino rats using streptozotocin (45 mg/kg). Hydroxyl Radical 34-50 glutamate decarboxylase 2 Homo sapiens 60-66 26362234-7 2015 Immunogenicity of both native and hydroxyl radical modified GAD-65 (ROS-GAD-65) was studied in experimental rabbits and was confirmed by inducing type I diabetes in experimental male albino rats using streptozotocin (45 mg/kg). Hydroxyl Radical 34-50 glutamate decarboxylase 2 Homo sapiens 68-78 26717598-4 2015 Catalase (scavenger of hydrogen peroxide), mannitol (scavenger of hydroxyl radicals) and superoxide dismutase (scavenger of superoxide radicals) reduced the level of ROS production under LA, suggesting the generation of H2O2, OH* and O2- radicals, respectively. Hydroxyl Radical 66-83 catalase Homo sapiens 0-8 26150471-8 2015 However, S. aureus cells express catalase, and the antibiotic-mediated increase in hydroxyl radical formation was correlated with reduced katA expression and catalase activity in the presence of either antibiotic. Hydroxyl Radical 83-99 AT695_RS10915 Staphylococcus aureus 158-166 26200667-4 2015 In this paper, we use isomer-resolved product measurements of a series of normal-alkanes (C18, C20, C22, and C24) to distinguish between gas-phase and heterogeneous oxidation products formed by reaction with hydroxyl radicals (OH). Hydroxyl Radical 208-225 Bardet-Biedl syndrome 9 Homo sapiens 90-93 25770446-2 2015 CHCl2I and CHI3 react rapidly with hydroxyl radical (OH) produced by the UV/H2O2 system, with second-order rate constants of 8.0 x 10(9) and 8.9 x 10(9) M(-1) s(-1), respectively. Hydroxyl Radical 35-51 chitinase 1 Homo sapiens 11-15 26183542-7 2015 Compound 23 (IC50=34.64 +- 0.35 muM) was found to be the most active among compounds having single hydroxyl substitution. Hydroxyl Radical 99-107 latexin Homo sapiens 32-35 25824465-5 2015 The scavenging ability of the complexes towards 1,1-diphenyl-picrylhydrazyl, 2,2"-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) and hydroxyl radicals was investigated and the in vitro inhibitory activity against soybean lipoxygenase was evaluated and complexes 4 and 5 were the more active compounds among those tested. Hydroxyl Radical 135-152 linoleate 9S-lipoxygenase-4 Glycine max 223-235 25783628-6 2015 Because variants CAT(A138S) and CAT(A138V), which were generated via in vitro site-directed mutagenesis, were more thermostable than CAT, the thermostability enhancement resulting from the A138T replacement can be attributed to both the presence of a hydroxyl group and the bulk of the threonine side chain. Hydroxyl Radical 251-259 CAT Staphylococcus aureus 17-20 25783628-6 2015 Because variants CAT(A138S) and CAT(A138V), which were generated via in vitro site-directed mutagenesis, were more thermostable than CAT, the thermostability enhancement resulting from the A138T replacement can be attributed to both the presence of a hydroxyl group and the bulk of the threonine side chain. Hydroxyl Radical 251-259 CAT Staphylococcus aureus 32-35 25783628-6 2015 Because variants CAT(A138S) and CAT(A138V), which were generated via in vitro site-directed mutagenesis, were more thermostable than CAT, the thermostability enhancement resulting from the A138T replacement can be attributed to both the presence of a hydroxyl group and the bulk of the threonine side chain. Hydroxyl Radical 251-259 CAT Staphylococcus aureus 32-35 25990830-3 2015 Myosin isolated from pork muscle was solubilized in 0.5 M NaCl at pH 6.2 then oxidatively stressed with an iron-redox cycling system that produces hydroxyl radicals with or without 1 mM PP and 2 mM MgCl2 at 4 C for 12 or 24 h then heated to 50 C at 1.3 C/min. Hydroxyl Radical 147-164 myosin heavy chain 14 Homo sapiens 0-6 25936373-4 2015 Therefore, the objective of the present study was to assess whether H2, a ROS scavenger, has a therapeutic effect on psoriasis-associated inflammation by reducing hydroxyl radicals or peroxynitrite in the immunogenic psoriasis cascade. Hydroxyl Radical 163-180 relaxin 2 Homo sapiens 68-70 25964204-3 2015 One compound with m-phenolic hydroxyl group, called SYK-146, is a highly selective, potent agonist for the kappa receptor, with activity nearly equivalent to that of U-50488H. Hydroxyl Radical 29-37 spleen associated tyrosine kinase Homo sapiens 52-55 26030156-6 2015 The results showed that DLA could activate SIRT1 after I/R probably by binding to this protein, depending on phenolic hydroxyl. Hydroxyl Radical 118-126 sirtuin 1 Rattus norvegicus 43-48 25962102-5 2015 The results suggested that three hydroxyl or two methoxyl moieties on the aromatic ring are essential for the stimulation of GLP-1 secretion. Hydroxyl Radical 33-41 glucagon Mus musculus 125-130 25891820-1 2015 DFT calculations concerning the plausible mechanism of Fenton-like reactions catalyzed by Fe(II) and Co(II) cations in the presence of carboxylate ligands suggest that hydroxyl radicals are not formed in these reactions. Hydroxyl Radical 168-185 mitochondrially encoded cytochrome c oxidase II Homo sapiens 101-107 25760536-1 2015 Dehydroepiandrosterone sulfotransferase (SULT2A1) plays an important role in the detoxification of hydroxyl-containing xenobitotics and in the regulation of the biological activities of hydroxysteroids. Hydroxyl Radical 99-107 sulfotransferase family 2A member 1 Rattus norvegicus 41-48 25769286-3 2015 Despite the available heterologous biosynthesis of their aglycone (protopanaxadiol, PPD) in yeast, production of Rh2 and Rg3 by a synthetic biology approach was hindered by the absence of bioparts to glucosylate the C3 hydroxyl of PPD. Hydroxyl Radical 219-227 Rh associated glycoprotein Homo sapiens 113-116 25660964-3 2015 The ability of the complexes to scavenge 1,1-diphenyl-picrylhydrazyl, 2,2"-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) and hydroxyl radicals was investigated and the in vitro inhibitory activity against soybean lipoxygenase was evaluated; complexes 3 and 4 were the most active compounds. Hydroxyl Radical 128-145 linoleate 9S-lipoxygenase-4 Glycine max 216-228 25726326-4 2015 Upon inhibition of tyrosinase, RD is converted to new products such as tyrosinase-catalyzed hydroxyl-metabolite, which damage melanocytes. Hydroxyl Radical 92-100 tyrosinase Homo sapiens 19-29 25726326-4 2015 Upon inhibition of tyrosinase, RD is converted to new products such as tyrosinase-catalyzed hydroxyl-metabolite, which damage melanocytes. Hydroxyl Radical 92-100 tyrosinase Homo sapiens 71-81 26248410-0 2015 [Effects of hydroxyl acetylated curcumin induced sonodynamic therapy on viability, apoptosis and necrosis of THP-1 macrophages]. Hydroxyl Radical 12-20 GLI family zinc finger 2 Homo sapiens 109-114 25690286-3 2015 Results indicated that CPF1 (molecular weight less than 1 kDa) and CPF2 (molecular weight between 1 and 3 kDa) exhibited good hydroxyl radical, superoxide anion radical and 2,2"-azino-bis (3-ethylbenzothiazoline-6-sulphonicacid) diammonium salt (ABTS) radical scavenging activity and oxygen radical absorbance capacity (ORAC). Hydroxyl Radical 126-142 cytochrome P450 family 4 subfamily F member 2 Homo sapiens 67-71 25752613-0 2015 High structural resolution hydroxyl radical protein footprinting reveals an extended Robo1-heparin binding interface. Hydroxyl Radical 27-43 roundabout 1 Drosophila melanogaster 85-90 25897359-0 2015 Tyrosine isomers and hormonal signaling: A possible role for the hydroxyl free radical in insulin resistance. Hydroxyl Radical 65-73 insulin Homo sapiens 90-97 25688346-7 2015 On one hand, drugs with free hydroxyl on amino groups (e.g., hydralazine, procainamide) could interact with C4A, C4B, or C3 and cause an SLE-like disease. Hydroxyl Radical 29-37 complement C4B (Chido blood group) Homo sapiens 113-123 25760528-4 2015 UDP-glucuronosyltransferase (UGT) is a non-P450 enzyme that catalyzes glucuronidation, a major pathway for drugs possessing carboxylic acid, hydroxyl, and amine moieties. Hydroxyl Radical 141-149 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 0-27 25760528-4 2015 UDP-glucuronosyltransferase (UGT) is a non-P450 enzyme that catalyzes glucuronidation, a major pathway for drugs possessing carboxylic acid, hydroxyl, and amine moieties. Hydroxyl Radical 141-149 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 29-32 25536026-4 2015 PLP exhibited scavenging abilities against hydroxyl, peroxyl anion, and DPPH radicals in vitro and showed significant binding capacities against cholic and chenodeoxycholic acids, suggesting its possible cholesterol-lowering activity. Hydroxyl Radical 43-51 proteolipid protein 1 Homo sapiens 0-3 25486622-6 2015 The contributions of the hydroxyl radical (OH) to 2-MIB and geosmin degradation were 3.5 times and 2.0 times higher, respectively, than the contribution from SO4(-) in Milli-Q water with 2 mM phosphate buffer at pH 7.0. Hydroxyl Radical 25-41 MIB E3 ubiquitin protein ligase 1 Homo sapiens 52-55 25422125-11 2015 Hydroxyl radical-mediated N-terminal cyclization was also observed in other Ang peptides containing N-terminal alanine, arginine, valine, and amyloid beta 1-11 (DAEFRHDSGYE). Hydroxyl Radical 0-16 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 150-159 25388158-0 2015 Palladium catalyzed Csp2-H activation for direct aryl hydroxylation: the unprecedented role of 1,4-dioxane as a source of hydroxyl radicals. Hydroxyl Radical 122-139 regulator of calcineurin 2 Homo sapiens 20-24 25564678-8 2015 NOX-induced activation of TRPA1 sparklets and vasodilation required generation of hydrogen peroxide and lipid-peroxidizing hydroxyl radicals as intermediates. Hydroxyl Radical 123-140 transient receptor potential cation channel subfamily A member 1 Homo sapiens 26-31 25316421-3 2015 To investigate the antioxidant activity of P-DIP, we determined the scavenging activity of hydroxyl radicals and DPPH, as well as the reducing power. Hydroxyl Radical 91-108 protein disulfide isomerase family A member 2 Homo sapiens 43-48 25861631-7 2015 Hydroxyl radical was generated by adding a mixture of tyrosinase and H2O2 to RD, and the amount of the radical was further increased by UVB, indicating that RD cytotoxicity was caused by intracellularly increased ROS, which possibly related to phenol induced prooxidants. Hydroxyl Radical 0-16 tyrosinase Mus musculus 54-64 25965476-7 2015 In vitro antioxidant assay, GPA1, GPA2 and GPA3 could scavenge 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical and hydroxyl radical, chelate ferrous ion and reduce ferric ion. Hydroxyl Radical 113-129 glycoprotein hormone subunit alpha 2 Homo sapiens 34-38 25447761-5 2014 PME inhibited lipid peroxidation with an IC50 of 34.35 microg/ml and protected the plasmid DNA from damage by hydroxyl radicals to varying degrees. Hydroxyl Radical 110-127 cystatin B Homo sapiens 0-3 25269106-3 2014 The rates of hydroxyl radical (OH) production for Fe(III)-oxalate/H2O2/UV (350 nm) and Fe(III)-oxalate/H2O2/visible (450 nm) systems were 1.19 +- 0.12 and 0.30 +- 0.01 muM/min, respectively. Hydroxyl Radical 13-29 latexin Homo sapiens 168-171 25245420-4 2014 Based on hydroxyl radical-mediated oxidation of proteins and analysis by nanoscale liquid chromatography coupled to tandem mass spectrometry (nanoLC-MS/MS), two sites of adsorption of myoglobin on silica nanoparticles are identified. Hydroxyl Radical 9-25 myoglobin Homo sapiens 184-193 28510944-8 2014 Like total antioxidant status, DPPH radical scavenging activity, reducing power, Fe2+-chelating ability, FTC activity, and protecting calf thymus DNA against hydroxyl radical-induced damage all showed that MT-1 and MT-II proteins have antioxidant activities. Hydroxyl Radical 158-174 melatonin receptor 1A Bos taurus 206-210 28510944-8 2014 Like total antioxidant status, DPPH radical scavenging activity, reducing power, Fe2+-chelating ability, FTC activity, and protecting calf thymus DNA against hydroxyl radical-induced damage all showed that MT-1 and MT-II proteins have antioxidant activities. Hydroxyl Radical 158-174 metallothionein-2 Bos taurus 215-220 25697519-2 2015 Radiolysis-based hydroxyl radical footprinting (HRF) strategies coupled to mass spectrometry have been used to explore the structural waters within rhodopsin in multiple signaling states. Hydroxyl Radical 17-33 rhodopsin Homo sapiens 148-157 25618122-3 2014 GGT also plays an important pro-oxidant role, stimulating the generation of hydroxyl radicals, and increases membrane lipid peroxidation. Hydroxyl Radical 76-93 inactive glutathione hydrolase 2 Homo sapiens 0-3 25414704-4 2014 We hypothesized that HSA-Trx would attenuate the enhanced ROS production of species such as hydroxyl radicals by neutrophils during an influenza viral infection. Hydroxyl Radical 92-109 thioredoxin 1 Mus musculus 25-28 25179574-11 2014 These findings indicate that AG490 significantly reduces H2O2-induced TRPM2 activation, presumably by scavenging hydroxyl radicals rather than Jak2-dependent mechanisms. Hydroxyl Radical 113-130 transient receptor potential cation channel subfamily M member 2 Homo sapiens 70-75 25096900-0 2014 In vitro effect of H2O 2, some transition metals and hydroxyl radical produced via fenton and fenton-like reactions, on the catalytic activity of AChE and the hydrolysis of ACh. Hydroxyl Radical 53-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 25076379-2 2014 The 8-hydroxyl group, other than the 7-hydroxyl was confirmed crucial to the interaction with the dopamine D1 receptor. Hydroxyl Radical 6-14 dopamine receptor D1 Homo sapiens 98-118 25353381-3 2014 The formation of hydroxyl radicals, evidenced as the corresponding spin-adducts, dominated in the irradiated TiO2 aqueous suspensions. Hydroxyl Radical 17-34 spindlin 1 Homo sapiens 67-71 25297374-1 2014 BACKGROUND: Hydroxyl radical that has the highest reactivity among reactive oxygen species (ROS) is generated through L-tyrosine-tyrosinase reaction. Hydroxyl Radical 12-28 tyrosinase Homo sapiens 129-139 25064486-8 2014 The model confirmed that short-lived hydroxyl radicals were present at a radial distance far beyond the ~18 mum photon penetration layer. Hydroxyl Radical 37-54 latexin Homo sapiens 108-111 25271969-0 2014 Theoretical kinetics studies on the reaction of CF3CF CF2 with hydroxyl radical. Hydroxyl Radical 63-79 ATPase H+ transporting accessory protein 1 Homo sapiens 54-57 25297374-4 2014 The aim of the present study was to examine if arbutin could suppress the hydroxyl radical generation via tyrosinase reaction with its substrates, L-tyrosine and L-DOPA. Hydroxyl Radical 74-90 tyrosinase Homo sapiens 106-116 25297374-5 2014 RESULTS: The hydroxyl radical, which was determined by an electron spin resonance-spin trapping technique, was generated by the addition of not only L-tyrosine but L-DOPA to tyrosinase in a concentration dependent manner. Hydroxyl Radical 13-29 tyrosinase Homo sapiens 174-184 25324649-0 2014 Preferential recognition of hydroxyl radical-modified superoxide dismutase by circulating autoantibodies in patients with alopecia areata. Hydroxyl Radical 28-44 superoxide dismutase 1 Homo sapiens 54-74 25324649-3 2014 OBJECTIVE: The aim of this study was to investigate the role of a hydroxyl radicals ( OH)-modified antioxidant enzyme, superoxide dismutase (SOD), in AA autoimmunity. Hydroxyl Radical 66-83 superoxide dismutase 1 Homo sapiens 119-139 25324649-3 2014 OBJECTIVE: The aim of this study was to investigate the role of a hydroxyl radicals ( OH)-modified antioxidant enzyme, superoxide dismutase (SOD), in AA autoimmunity. Hydroxyl Radical 66-83 superoxide dismutase 1 Homo sapiens 141-144 25010574-0 2014 Hydroxyl radical recycling in isoprene oxidation driven by hydrogen bonding and hydrogen tunneling: the upgraded LIM1 mechanism. Hydroxyl Radical 0-16 LIM homeobox 1 Homo sapiens 113-117 25082450-10 2014 CONCLUSION: The generation of a tyrosinase-catalyzed hydroxyl-metabolite is one of the causes for the diminishment of the melanocyte viability by rhododendrol. Hydroxyl Radical 53-61 tyrosinase Homo sapiens 32-42 25942901-1 2014 We studied the interaction of di-isopropylaminosilane (SiH3N(C3H7)2, DIPAS) molecules with a fully hydroxyl-terminated Si (001) surface for SiO2 thin-film growth by using density functional theory. Hydroxyl Radical 99-107 PAPPA antisense RNA 1 Homo sapiens 69-74 25229820-4 2014 The most significant AOC descriptors for the studied compounds against peroxyl radical were found to be HOMO energy, rigidity (eta) and Mulliken charge on the carbon atom in m-position to the phenolic hydroxyl. Hydroxyl Radical 201-209 endothelin receptor type A Homo sapiens 127-130 24699295-6 2014 Furthermore, the title compounds were investigated for their antibacterial activity using inhibition zone diameter and for DNA degradation, superoxide-scavenging activity as well as hydroxyl radicals that generated by the oxidation of cytochrome c in L-ascorbic acid/CuSO4-cytochrome c system. Hydroxyl Radical 182-199 cytochrome c, somatic Homo sapiens 235-247 24552404-8 2014 AS1-4, four isoprenylated flavones, potently quenched superoxide anion, hydroxyl radical, and hydrogen peroxide at the concentration of 20 microM with their scavenging rates in the range of 30.1-78.1%, 35.4-69.7%, and 65.5-86.3%, respectively. Hydroxyl Radical 72-88 PDS5 cohesin associated factor B Rattus norvegicus 0-5 25144692-9 2014 A credible photodegradation mechanism for the MB dye deploying ZnO/Ag2S core/shell nanostructures is proposed from the analysis of involved active species such as hydroxyl radicals (OH( )), electrons (e(-)(CB)), holes (h(+)(VB)), and superoxide radical anions (O2( -)) in the photodegradation process utilizing various active species scavengers and EPR spectroscopy. Hydroxyl Radical 163-180 angiotensin II receptor type 1 Homo sapiens 67-71 25140150-8 2014 Additionally, by using structure activity relationship data obtained from fourteen structurally similar benzoic acid derivatives, it was determined that the inhibition of alpha-syn fibrillation by GA is related to the number of hydroxyl moieties and their position on the phenyl ring. Hydroxyl Radical 228-236 synuclein alpha Homo sapiens 171-180 25108730-11 2014 The 6:2 FTS was first attacked by hydroxyl radical, and then formed perfluorinated carboxylates, which decarboxylated and removed CF2 units to yield shorter-chain perfluorocarboxylic acids. Hydroxyl Radical 34-50 AKT interacting protein Homo sapiens 8-11 25108730-11 2014 The 6:2 FTS was first attacked by hydroxyl radical, and then formed perfluorinated carboxylates, which decarboxylated and removed CF2 units to yield shorter-chain perfluorocarboxylic acids. Hydroxyl Radical 34-50 ATPase H+ transporting accessory protein 1 Homo sapiens 130-133 24656855-4 2014 Results from the CV analysis showed that the Pt-FTO and Pt/MWCNTs-FTO electrodes possessed dual functions of decreasing activation energy and interactions between hydroxyl radicals to effectively degrade naproxen. Hydroxyl Radical 163-180 FTO alpha-ketoglutarate dependent dioxygenase Homo sapiens 48-51 24656855-4 2014 Results from the CV analysis showed that the Pt-FTO and Pt/MWCNTs-FTO electrodes possessed dual functions of decreasing activation energy and interactions between hydroxyl radicals to effectively degrade naproxen. Hydroxyl Radical 163-180 FTO alpha-ketoglutarate dependent dioxygenase Homo sapiens 66-69 24873476-1 2014 We introduce a versatile ABC triblock terpoly- mer platform based on poly(ethylene oxide)-block-poly(allyl glycidyl ether)-block-poly(tert-butyl glycidyl ether) (PEO-b-PAGE-b-PtBGE) and subsequent functionalization of the PAGE segment with thiogalactose (hydroxyl), cysteamine (amino), and 2-mercaptopropionic acid (carboxy) by thiol-ene chemistry. Hydroxyl Radical 255-263 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 25-28 24723458-8 2014 The results demonstrated high activities of SL21 in scavenging free radicals (DPPH, ABTS( +) , and hydroxyl), chelating of Cu(2+) /Fe(2+) metal ions, reducing power, and inhibition of lipid peroxidation in a concentration-dependent manner. Hydroxyl Radical 99-107 MAP6 domain containing 1 Homo sapiens 44-48 24850884-5 2014 Direct hydroxyl radical probing of the entire 28S rRNA revealed that SBP2 bound to 80S ribosomes or 60S subunits protects helix ES7L-E in expansion segment 7 of the 28S rRNA. Hydroxyl Radical 7-15 SECIS binding protein 2 Homo sapiens 69-73 24631548-5 2014 The results showed that r-EPS1 and r-EPS2 exhibited potent antioxidant activities regarding hydroxyl and DPPH radicals scavenging and reducing power assays, and possessed antitumor activities against Caco-2, BGC-823 and HT-29 cells, which suggested that they could be potential sources of antioxidant and antitumor drug. Hydroxyl Radical 92-100 RALBP1 associated Eps domain containing 1 Homo sapiens 24-41 24723458-9 2014 SL21 neuropeptide revealed a protective effect on DNA damage caused by hydroxyl radicals. Hydroxyl Radical 71-88 MAP6 domain containing 1 Homo sapiens 0-4 24811874-5 2014 The average percent exposure to hydroxyl radical-mediated modification in the SEM1(86-107) fibrils was determined without requiring tandem mass spectrometry spectral acquisition or complete separation of modified peptides. Hydroxyl Radical 32-48 SEM1 26S proteasome subunit Homo sapiens 78-82 24840575-3 2014 Results demonstrated that curcumin and CAs possessed potent inhibitory activity against ALDH1, and the CAs compound with ortho di-hydroxyl groups showed the most potent inhibitory activity. Hydroxyl Radical 130-138 aldehyde dehydrogenase 1 family member A1 Homo sapiens 88-93 24631677-11 2014 The inhibition of PCMT1 promoter activity was mediated by dopamine-induced ROS since it was prevented by the hydroxyl radical scavenger N,N"-dimethylthiourea. Hydroxyl Radical 109-125 protein-L-isoaspartate (D-aspartate) O-methyltransferase Homo sapiens 18-23 24685330-14 2014 The GORK channel activity is stimulated by hydroxyl radicals that are generated in a Ca(2+)-dependent manner in stress conditions, such as salinity or pathogen attack, resulting in dramatic K(+) efflux from root cells. Hydroxyl Radical 43-60 gated outwardly-rectifying K+ channel Arabidopsis thaliana 4-8 24508920-4 2014 In vitro antioxidant assays demonstrated that ALP1 possessed moderate ABTS(+) scavenging activity, strong hydroxyl radical scavenging activity and strong ferrous ion chelating activity. Hydroxyl Radical 106-122 asparaginase like 1 Mus musculus 46-50 24763734-6 2014 The hydroxyl radical results indicate that NSC 176319, Cain"s quinolinium that was found by screening, exhibits selective binding to the two TT loops. Hydroxyl Radical 4-20 calcineurin binding protein 1 Homo sapiens 55-59 24617811-1 2014 This study demonstrates that the production of reactive oxidizing species (e.g., hydroxyl radical ( OH)) during the photolysis of nitrite (NO2(-)) or nitrate (NO3(-)) leads to the oxidative conversion of arsenite (As(III)) to arsenate (As(V)). Hydroxyl Radical 81-97 NBL1, DAN family BMP antagonist Homo sapiens 159-162 24607576-7 2014 The decrease of POD activity might contribute to a less accumulation of hydroxyl radical ( OH) under water stress. Hydroxyl Radical 72-88 peroxidase Solanum lycopersicum 16-19 24568234-9 2014 The ONE- and hydroxyl radical-derived formation of N-terminal alpha-ketoamide and its transamination in the presence of PM were also observed in amyloid beta 1-11 (DAEFRHDSGYE), where the N-terminal Asp was converted to epimeric alanine. Hydroxyl Radical 13-29 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 153-162 24491335-0 2014 Hydroxyl density affects the interaction of fibrinogen with silica nanoparticles at physiological concentration. Hydroxyl Radical 0-8 fibrinogen beta chain Homo sapiens 44-54 24564195-5 2014 The Co(II)-poly(EGDE-DA)/H2O2 heterogeneous system produced O2, an anion superoxide (O2( ) ), and a hydroxyl radical (OH( )), which diffused into the solution at the time that a decrease in pH was detected. Hydroxyl Radical 100-116 mitochondrially encoded cytochrome c oxidase II Homo sapiens 4-11 24691535-2 2014 The results show that the adsorption of HCN on rGO is generally stronger than that on graphene, which is due to the presence of the active defect sites in rGO, such as the hydroxyl, epoxide, and carboxyl functional groups and even the carbon atom near these groups. Hydroxyl Radical 172-180 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 40-43 24588834-4 2014 These results suggest that the stereochemistry and all substituents of spiroketal portion (rings E and F) and C3-alpha and C11-beta hydroxyl functional groups on rings A and C, respectively, are critical for the inhibitory activity of natural product 1. Hydroxyl Radical 132-140 complement C3 Homo sapiens 110-118 24588834-4 2014 These results suggest that the stereochemistry and all substituents of spiroketal portion (rings E and F) and C3-alpha and C11-beta hydroxyl functional groups on rings A and C, respectively, are critical for the inhibitory activity of natural product 1. Hydroxyl Radical 132-140 endogenous retrovirus group K member 20 Homo sapiens 123-131 24508645-9 2014 In addition, LF showed hydroxyl radical scavenger activity in vitro. Hydroxyl Radical 23-39 lactotransferrin Mus musculus 13-15 24486421-8 2014 In the reaction route using P2O5/CH3SO3H, the amino groups were shielded by the ionic binding with CH3SO3H, and the C-6 hydroxyl groups were phosphorylated. Hydroxyl Radical 120-128 complement C6 Homo sapiens 116-119 24277937-5 2014 With site-directed hydroxyl radical probing, we further revealed the binding between Brf1 cyclin repeats and the highly conserved region connecting C34 winged-helix domains 2 and 3. Hydroxyl Radical 19-35 BRF1 RNA polymerase III transcription initiation factor subunit Homo sapiens 85-89 23887274-6 2014 Indeed, it allowed to determine that the core structure of GIPC polar heads in plants is Hex(R1)-HexA-IPC, with R1 being a hydroxyl, an amine, or a N-acetylamine group, whereas the core structure in fungi is Man-IPC. Hydroxyl Radical 123-131 GIPC PDZ domain containing family member 1 Homo sapiens 59-63 24437906-1 2014 The mechanical and structural responses of hydroxyl-terminated cis-1,4-polybutadiene melts to shock waves were investigated by means of all-atom non-reactive molecular dynamics simulations. Hydroxyl Radical 43-51 suppressor of cytokine signaling 1 Homo sapiens 63-68 24188577-4 2014 Seven H-abstraction routes were reported, and the OH exclusively abstracted the phenolic hydroxyl (RabsOH) H atom, to form TCS(-H). Hydroxyl Radical 89-97 treacle ribosome biogenesis factor 1 Homo sapiens 123-126 24424315-1 2014 In this study, we examined the protective effect of lactoferrin against DNA damage induced by various hydroxyl radical generation systems. Hydroxyl Radical 102-118 lactotransferrin Bos taurus 52-63 24424315-0 2014 Lactoferrin directly scavenges hydroxyl radicals and undergoes oxidative self-degradation: a possible role in protection against oxidative DNA damage. Hydroxyl Radical 31-48 lactotransferrin Bos taurus 0-11 26180524-7 2014 Once this was determined, electron spin resonance (ESR) spin trapping was used to detect and measure hydroxyl or superoxide radicals in. Hydroxyl Radical 101-109 spindlin 1 Mus musculus 35-39 24315190-7 2014 Docking predictions suggest this specificity may be due to interaction of the aliphatic hydroxyl with His475 in the agonist form of ERbeta, versus with Thr299 in the antagonist form. Hydroxyl Radical 88-96 estrogen receptor 2 Homo sapiens 132-138 24274568-7 2014 The IC50 values of PMP-2 were 0.47, 0.6 and 0.93 mg/mL for superoxide anion scavenging, hydroxyl radical scavenging, and hydroxyl peroxide scavenging, respectively. Hydroxyl Radical 88-104 peripheral myelin protein 2 Rattus norvegicus 19-24 23965644-7 2014 Intriguingly, UGT1A1 exhibits the highest activity against both resveratrol and pterostilbene despite altered hydroxyl group specificity. Hydroxyl Radical 110-118 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 14-20 24424315-3 2014 Native LF, iron-saturated LF (holo-LF), and apolactoferrin (apo-LF) effectively suppressed strand breaks in plasmid DNA due to hydroxyl radicals produced by the Fenton reaction. Hydroxyl Radical 127-144 lactotransferrin Bos taurus 7-9 24424315-3 2014 Native LF, iron-saturated LF (holo-LF), and apolactoferrin (apo-LF) effectively suppressed strand breaks in plasmid DNA due to hydroxyl radicals produced by the Fenton reaction. Hydroxyl Radical 127-144 lactotransferrin Bos taurus 26-28 24424315-3 2014 Native LF, iron-saturated LF (holo-LF), and apolactoferrin (apo-LF) effectively suppressed strand breaks in plasmid DNA due to hydroxyl radicals produced by the Fenton reaction. Hydroxyl Radical 127-144 lactotransferrin Bos taurus 30-37 24424315-3 2014 Native LF, iron-saturated LF (holo-LF), and apolactoferrin (apo-LF) effectively suppressed strand breaks in plasmid DNA due to hydroxyl radicals produced by the Fenton reaction. Hydroxyl Radical 127-144 lactotransferrin Bos taurus 26-28 24013113-1 2014 There is a large number of boron containing minerals with water and/or hydroxyl units of which pinnoite MgB2O(OH)6 is one. Hydroxyl Radical 71-79 secretoglobin family 2A member 1 Homo sapiens 104-108 26180524-7 2014 Once this was determined, electron spin resonance (ESR) spin trapping was used to detect and measure hydroxyl or superoxide radicals in. Hydroxyl Radical 101-109 spindlin 1 Mus musculus 56-60 24579808-3 2014 In addition, both the superoxide anion and the hydroxyl radical were scavenged by GBE in cell-free systems. Hydroxyl Radical 47-63 1,4-alpha-glucan branching enzyme 1 Homo sapiens 82-85 24345237-5 2014 This research also sheds light on the inactivation of MS2 with ultraviolet light and in the presence of hydroxyl radicals and provides a practical use of qPCR to detect MS2 concentration following advanced oxidation relative to traditional plaque methodology; however qPCR detection overestimates the true number of infective virus. Hydroxyl Radical 104-121 MS2 Homo sapiens 54-57 24205994-1 2013 In this work is investigated why the entrance of a nitrogen atom in the ring of cis-2-hydroxypyridine and 2-pyridinone, resulting in cis-4-hydroxypyrimidine and 4(3H)-pyrimidinone, respectively, shifts the tautomeric equilibrium from the hydroxyl form, in the pyridine derivative, to the ketonic form, in the pyrimidine derivative. Hydroxyl Radical 238-246 suppressor of cytokine signaling 2 Homo sapiens 80-85 24261790-8 2013 These results demonstrate that shape, crystallinity, and hydroxyl content play an important role in NLRP3 inflammasome activation and are therefore useful for quantitative boosting of antigen-specific immune responses. Hydroxyl Radical 57-65 NLR family pyrin domain containing 3 Homo sapiens 100-105 24145744-7 2013 Interestingly hept-1-ene isomerization gives a volcano curve for the conversion as a function of hydroxyl coverage. Hydroxyl Radical 97-105 selenoprotein I Homo sapiens 14-20 24313818-3 2013 Moreover, Cu-Abeta complexes are able to catalyze the production of hydrogen peroxide and hydroxyl radicals, and oligomeric Cu-Abeta was reported to be more reactive. Hydroxyl Radical 90-107 amyloid beta precursor protein Homo sapiens 13-18 24313818-3 2013 Moreover, Cu-Abeta complexes are able to catalyze the production of hydrogen peroxide and hydroxyl radicals, and oligomeric Cu-Abeta was reported to be more reactive. Hydroxyl Radical 90-107 amyloid beta precursor protein Homo sapiens 127-132 24012475-6 2013 These results suggest that halogenated compounds may disturb thyroid hormone homeostasis via inhibition of IYD, and that the structural requirements for IYD-inhibitory activity include halogen atom and hydroxyl group substitution on a phenyl ring. Hydroxyl Radical 202-210 iodotyrosine deiodinase Homo sapiens 153-156 23933580-2 2013 A member of the solute carrier (SLC) family, Slc26a6, has been shown to be a chloride-hydroxyl exchanger and the predominant chloride-bicarbonate exchanger in the mouse heart. Hydroxyl Radical 86-94 solute carrier family 26, member 6 Mus musculus 45-52 23933552-2 2013 The behavior of the hydroxyl/water molecular units of goethite and its thermally treated products were characterized using Fourier transform-infrared emission spectroscopy (FT-IES) and attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy. Hydroxyl Radical 20-28 ATR serine/threonine kinase Homo sapiens 242-245 24323422-9 2013 However, ferrous ion can react with hydrogen peroxide to produce pro-oxidant hydroxyl radicals which may explain the harmful role of HO-1 in intracerebral hemorrhage. Hydroxyl Radical 77-94 heme oxygenase 1 Homo sapiens 133-137 24205994-1 2013 In this work is investigated why the entrance of a nitrogen atom in the ring of cis-2-hydroxypyridine and 2-pyridinone, resulting in cis-4-hydroxypyrimidine and 4(3H)-pyrimidinone, respectively, shifts the tautomeric equilibrium from the hydroxyl form, in the pyridine derivative, to the ketonic form, in the pyrimidine derivative. Hydroxyl Radical 238-246 suppressor of cytokine signaling 6 Homo sapiens 133-138 23768398-5 2013 The addition of catalase and superoxide dismutase (SOD) prevented the hydroxyl radical driven-degradation of beta-glucan induced by iron(II) or ascorbic acid/iron(II), demonstrating the involvement of both superoxide and hydrogen peroxide in the hydroxyl radical formation. Hydroxyl Radical 246-262 catalase Homo sapiens 16-24 23768398-5 2013 The addition of catalase and superoxide dismutase (SOD) prevented the hydroxyl radical driven-degradation of beta-glucan induced by iron(II) or ascorbic acid/iron(II), demonstrating the involvement of both superoxide and hydrogen peroxide in the hydroxyl radical formation. Hydroxyl Radical 70-86 catalase Homo sapiens 16-24 23768398-5 2013 The addition of catalase and superoxide dismutase (SOD) prevented the hydroxyl radical driven-degradation of beta-glucan induced by iron(II) or ascorbic acid/iron(II), demonstrating the involvement of both superoxide and hydrogen peroxide in the hydroxyl radical formation. Hydroxyl Radical 70-86 superoxide dismutase 1 Homo sapiens 29-49 23768398-5 2013 The addition of catalase and superoxide dismutase (SOD) prevented the hydroxyl radical driven-degradation of beta-glucan induced by iron(II) or ascorbic acid/iron(II), demonstrating the involvement of both superoxide and hydrogen peroxide in the hydroxyl radical formation. Hydroxyl Radical 70-86 superoxide dismutase 1 Homo sapiens 51-54 23768398-5 2013 The addition of catalase and superoxide dismutase (SOD) prevented the hydroxyl radical driven-degradation of beta-glucan induced by iron(II) or ascorbic acid/iron(II), demonstrating the involvement of both superoxide and hydrogen peroxide in the hydroxyl radical formation. Hydroxyl Radical 246-262 superoxide dismutase 1 Homo sapiens 29-49 23768398-5 2013 The addition of catalase and superoxide dismutase (SOD) prevented the hydroxyl radical driven-degradation of beta-glucan induced by iron(II) or ascorbic acid/iron(II), demonstrating the involvement of both superoxide and hydrogen peroxide in the hydroxyl radical formation. Hydroxyl Radical 246-262 superoxide dismutase 1 Homo sapiens 51-54 23918933-4 2013 The interaction between NBS1 and DNMT1 was observed under conditions of hydroxyl urea treatment, resulting in replication stall and mitomycin C treatment resulting in DNA damage. Hydroxyl Radical 72-80 nibrin Homo sapiens 24-28 23918933-4 2013 The interaction between NBS1 and DNMT1 was observed under conditions of hydroxyl urea treatment, resulting in replication stall and mitomycin C treatment resulting in DNA damage. Hydroxyl Radical 72-80 DNA methyltransferase 1 Homo sapiens 33-38 23311917-7 2013 These Michael acceptor-centric pharmacophores, when substituted with the hydroxyl and fluorine groups, gave rise to analogs displaying a TrxR inhibitory character positively correlated to their antiproliferative potencies. Hydroxyl Radical 73-81 peroxiredoxin 5 Rattus norvegicus 137-141 23311917-10 2013 CONCLUSION: A strong TrxR inhibitory character correlated to the antiproliferative potency is attributed to structural features that include an alpha,beta-unsaturated carbonyl moiety centered in a DPPen or DPPro pharmacophore bearing hydroxyl and fluorine substitutions. Hydroxyl Radical 234-242 peroxiredoxin 5 Rattus norvegicus 21-25 23716564-4 2013 Ile533Val is a novel mutation and represents the genetic HIF2A change nearest to Pro-531, the primary hydroxyl acceptor residue, so far identified. Hydroxyl Radical 102-110 endothelial PAS domain protein 1 Homo sapiens 57-62 23941465-3 2013 The hydroxylation reaction catalyzed by HPPD displaces the aceto substituent of HPA in a 1,2-shift to form 2,5-dihydroxyphenylacetate (homogentisate, HG), whereas the hydroxylation reaction of HMS places a hydroxyl on the benzylic carbon forming 3"-hydroxyphenylacetate (S-hydroxymandelate, HMA) without ensuing chemistry. Hydroxyl Radical 4-12 4-hydroxyphenylpyruvate dioxygenase Homo sapiens 40-44 23770489-4 2013 Approximately 38% of HO was generated by the photolysis of ferric ions, and the formation of the remaining 62% was strongly dependent on the HO2 /O2- . Hydroxyl Radical 21-23 heme oxygenase 2 Homo sapiens 142-145 23895017-6 2013 A plausible mechanism of toluene degradation using [FeCl2(bpmcn)] (1) and [Fe(OTf)2(Pytacn)] (3) as catalysts was proposed, which involves the coexistence of a metal-based path, analogous to that operating in organic media where substrate oxidation is executed by an iron(V)-oxo-hydroxo species, in parallel to a Fenton-type process where hydroxyl radicals are formed. Hydroxyl Radical 339-356 POU class 2 homeobox 2 Homo sapiens 78-83 23062287-5 2013 UPF1, a tetrapeptide GSH analogue, 4-methoxy-L-tyrosinyl-gamma-L-glutamyl-L-cysteinyl-glycine, known to possess a 50-fold higher hydroxyl radical scavenging efficiency than does GSH, normalized the intracellular GSH level in the human bronchial epithelial cells under oxidative stress caused by CSC. Hydroxyl Radical 129-145 UPF1 RNA helicase and ATPase Homo sapiens 0-4 23865454-4 2013 Here we show for the first time a direct comparison of the abilities of Sec-containing mTR3 and the Cys-orthologue from D. melanogaster (DmTR) to resist inactivation by oxidation from a variety of oxidants including H2O2, hydroxyl radical, peroxynitrite, hypochlorous acid, hypobromous acid, and hypothiocyanous acid. Hydroxyl Radical 222-238 eukaryotic elongation factor, selenocysteine-tRNA-specific Mus musculus 72-75 23811078-3 2013 In vitro antioxidant assay, CLSP had noticeable scavenging activities on superoxide anion, hydroxyl radical and 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radical. Hydroxyl Radical 91-107 calmodulin like 5 Homo sapiens 28-32 23685046-8 2013 Antioxidant assays demonstrated that HPS4-2A possessed of strong DPPH and hydroxyl radicals scavenging activities, suggesting that HPS4-2A could potentially be used as natural antioxidant. Hydroxyl Radical 74-91 HPS4 biogenesis of lysosomal organelles complex 3 subunit 2 Homo sapiens 37-41 23793354-9 2013 Similarly, human amylin was found to also decrease hydroxyl radical formation elicited by Cu(2+) and glutathione. Hydroxyl Radical 51-67 islet amyloid polypeptide Homo sapiens 17-23 23865454-4 2013 Here we show for the first time a direct comparison of the abilities of Sec-containing mTR3 and the Cys-orthologue from D. melanogaster (DmTR) to resist inactivation by oxidation from a variety of oxidants including H2O2, hydroxyl radical, peroxynitrite, hypochlorous acid, hypobromous acid, and hypothiocyanous acid. Hydroxyl Radical 222-238 thioredoxin reductase 2 Mus musculus 87-91 23576093-5 2013 Hydroxyls act as the co-catalyst in the CO oxidation by hydroxyls to CO2 (PROX reaction), while they act as one of the reactants in the CO oxidation by hydroxyls to CO2 and H2 (WGS reaction), and the recombinative reaction of hydroxyls to produce H2 is the rate-limiting step in the WGS reaction. Hydroxyl Radical 0-9 pyruvate dehydrogenase complex component X Homo sapiens 74-78 23576093-5 2013 Hydroxyls act as the co-catalyst in the CO oxidation by hydroxyls to CO2 (PROX reaction), while they act as one of the reactants in the CO oxidation by hydroxyls to CO2 and H2 (WGS reaction), and the recombinative reaction of hydroxyls to produce H2 is the rate-limiting step in the WGS reaction. Hydroxyl Radical 56-65 pyruvate dehydrogenase complex component X Homo sapiens 74-78 23721262-4 2013 We have shown that trivalent iron (FeIII) initiates a hydroxyl radical-catalyzed conversion of fibrinogen into a fibrin-like polymer (parafibrin) that is remarkably resistant to the proteolytic dissolution and thus promotes its intravascular deposition. Hydroxyl Radical 54-70 fibrinogen beta chain Homo sapiens 95-105 23702900-8 2013 In the absorption spectra of products resulting from the reaction of the hydroxyl radicals with elastin two bands were observed. Hydroxyl Radical 73-90 elastin Homo sapiens 96-103 23689876-0 2013 Leptin"s activity on the hydroxyl radical: a possible link to the oxidative stress-related endothelial vasodilation in patients with obstructive sleep apnea. Hydroxyl Radical 25-41 leptin Homo sapiens 0-6 24101387-1 2013 Reactive oxygen species (ROS), such as hydrogen peroxide, superoxide anion radical or hydroxyl radical, play an important role in inflammation processes as well as in transduction of signals from receptors to interleukin -1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha) or lipopolysaccharides (LPS). Hydroxyl Radical 86-102 interleukin 1 beta Homo sapiens 209-227 24101387-1 2013 Reactive oxygen species (ROS), such as hydrogen peroxide, superoxide anion radical or hydroxyl radical, play an important role in inflammation processes as well as in transduction of signals from receptors to interleukin -1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha) or lipopolysaccharides (LPS). Hydroxyl Radical 86-102 interleukin 1 beta Homo sapiens 229-237