PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
3791183-0	1986	Ornithine decarboxylase activity and DNA synthesis in rats after long term treatment with butylated hydroxyanisole, sodium saccharin or phenobarbital.	Saccharin	116-132	ornithine decarboxylase 1	Rattus norvegicus	0-23
3840294-3	1985	The incubation of a suspension of caecal contents from control rats with saccharin (75 mM) in vitro inhibited beta-glucuronidase and nitrate reductase activities, and ammonia production from endogenous substrates.	Saccharin	73-82	glucuronidase, beta	Rattus norvegicus	110-128
3952182-9	1986	These results indicate that both the carbachol and angiotensin II induce the ingestion of saccharin, NaCl and water.	Saccharin	90-99	angiotensinogen	Rattus norvegicus	51-65
6315223-15	1983	Intravesical saccharin also induced urinary bladder ODC activity, but TPA at equimolar quantity was far more potent than saccharin.	Saccharin	13-22	ornithine decarboxylase, structural 1	Mus musculus	52-55
3928589-5	1985	Enhancement of PRL production can be observed at 0.5 mM saccharin, yet this is 10 times less than the saccharin concentration required to alter cell shape.	Saccharin	56-65	prolactin	Rattus norvegicus	15-18
6121913-0	1982	Inhibitors of gastric acid secretion: 3,4-diamino-1,2,5-thiadiazole 1-oxides and 1,1-dioxides as urea equivalents in a series of histamine H2-receptor antagonists.	Saccharin	81-93	histamine receptor H2	Homo sapiens	129-150
6872157-2	1983	When the donors, HGPRT+ cells, and recipients, HGPRT- cells, were plated together in the presence of saccharin, all the interactions that developed in 4 and 24 h were positive for metabolic cooperation.	Saccharin	101-110	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	17-22
6872157-2	1983	When the donors, HGPRT+ cells, and recipients, HGPRT- cells, were plated together in the presence of saccharin, all the interactions that developed in 4 and 24 h were positive for metabolic cooperation.	Saccharin	101-110	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	47-52
32415404-4	2020	Two-bottle choice model showed that the overexpression of MMP-9 in the hippocampus developed by adeno-associated virus (AAV) could decrease alcohol consumption and preference, but did not affect taste preference, which was tested using saccharin or quinine solutions.	Saccharin	236-245	matrix metallopeptidase 9	Homo sapiens	58-63
33829293-0	2021	Saccharin and naltrexone prevent increased pain sensitivity and impaired long-term memory induced by repetitive neonatal noxious stimulation: role of BDNF and enkephalin.	Saccharin	0-9	brain-derived neurotrophic factor	Rattus norvegicus	150-154
33829293-0	2021	Saccharin and naltrexone prevent increased pain sensitivity and impaired long-term memory induced by repetitive neonatal noxious stimulation: role of BDNF and enkephalin.	Saccharin	0-9	proenkephalin	Rattus norvegicus	159-169
33829293-11	2021	Additionally, saccharin prevented hippocampal noxious stimulation induced BDNF decrement.	Saccharin	14-23	brain-derived neurotrophic factor	Rattus norvegicus	74-78
33367902-4	2021	Taste 1 receptor member 2 (TAS1R2) and taste 2 receptor member 31 (TAS2R31) were demonstrated to be abundantly expressed in the corpora lutea of rats, and intraperitoneal injection of saccharin sodium can activate both of them and initiate their downstream signaling cascades.	Saccharin	184-200	taste receptor type 1 member 2	Rattus norvegicus	0-25
33367902-4	2021	Taste 1 receptor member 2 (TAS1R2) and taste 2 receptor member 31 (TAS2R31) were demonstrated to be abundantly expressed in the corpora lutea of rats, and intraperitoneal injection of saccharin sodium can activate both of them and initiate their downstream signaling cascades.	Saccharin	184-200	taste receptor type 1 member 2	Rattus norvegicus	27-33
33622853-4	2021	Here, we aimed to identify a novel mechanism linking intestinal Akkermansia muciniphila and the aryl hydrocarbon receptor (AHR) to saccharin/sucralose-induced nonalcoholic fatty liver disease (NAFLD) in mice.	Saccharin	131-140	aryl-hydrocarbon receptor	Mus musculus	123-126
33622853-6	2021	Saccharin/sucralose also markedly decreased microbiota-derived AHR ligands and colonic AHR expression, which are closely associated with many metabolic syndromes.	Saccharin	0-9	aryl-hydrocarbon receptor	Mus musculus	63-66
7273302-0	1981	Long-term feeding study in C17 mice administered saccharin coated betel nut and 1,4-dinitrosopiperazine in combination.	Saccharin	49-58	cytokine-like 1	Mus musculus	27-30
147338-6	1978	Addition of saccharin to medium containing PAH and N-methylnicotinamide produced a dose-related depression of PAH accumulation.	Saccharin	12-21	phenylalanine hydroxylase	Rattus norvegicus	43-46
147338-6	1978	Addition of saccharin to medium containing PAH and N-methylnicotinamide produced a dose-related depression of PAH accumulation.	Saccharin	12-21	phenylalanine hydroxylase	Rattus norvegicus	110-113
403544-4	1977	In addition, when given an opportunity to drink either saccharine solution or water 24 h later, Group MSN rats drank significantly less saccharin than any of the control groups.	Saccharin	55-65	moesin	Rattus norvegicus	102-105
403544-4	1977	In addition, when given an opportunity to drink either saccharine solution or water 24 h later, Group MSN rats drank significantly less saccharin than any of the control groups.	Saccharin	55-64	moesin	Rattus norvegicus	102-105
33439009-6	2021	Mean levels of saccharin and resveratrol-3-O-sulfate in urine were 5.481 +- 4.359 and 3.440 +- 4.160 nmol L-1, respectively.	Saccharin	15-24	L1 cell adhesion molecule	Mus musculus	106-109
32608668-7	2020	The highest concentrations of acesulfame, saccharin, aspartame, and neotame in source water were 22.94, 39.17, 0.73, and 8.92 mug L-1, respectively, and detection rates were 72.7%, 90.9%, 18.2%, and 90.9%, respectively.	Saccharin	42-51	L1 cell adhesion molecule	Homo sapiens	130-133
30856053-2	2020	The present study aimed to evaluate the interaction of saccharin (SA) and sodium saccharin (SSA) with the promoter of the human p53 gene.	Saccharin	55-64	tumor protein p53	Homo sapiens	128-131
32179475-4	2020	We found that the specific deletion of metabotropic glutamate receptor 5 (mGluR5) in D1-expressing MSNs (D1miRmGluR5 mice) abolishes eCB-mediated long-term depression (LTD) and prevents the expression of drug (cocaine and ethanol), natural reward (saccharin), and brain-stimulation-seeking behavior.	Saccharin	248-257	glutamate receptor, metabotropic 5	Mus musculus	39-72
32179475-4	2020	We found that the specific deletion of metabotropic glutamate receptor 5 (mGluR5) in D1-expressing MSNs (D1miRmGluR5 mice) abolishes eCB-mediated long-term depression (LTD) and prevents the expression of drug (cocaine and ethanol), natural reward (saccharin), and brain-stimulation-seeking behavior.	Saccharin	248-257	glutamate receptor, ionotropic, kainate 1	Mus musculus	74-80
31972093-0	2020	1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors.	Saccharin	74-83	carbonic anhydrase 9	Homo sapiens	145-166
31972093-0	2020	1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors.	Saccharin	98-107	carbonic anhydrase 9	Homo sapiens	145-166
31843472-14	2020	Immediately following the microinjection of UII, consumption of both saccharin and sucrose increased compared to controls.	Saccharin	69-78	urotensin 2	Rattus norvegicus	44-47
30856053-2	2020	The present study aimed to evaluate the interaction of saccharin (SA) and sodium saccharin (SSA) with the promoter of the human p53 gene.	Saccharin	66-68	tumor protein p53	Homo sapiens	128-131
30856053-2	2020	The present study aimed to evaluate the interaction of saccharin (SA) and sodium saccharin (SSA) with the promoter of the human p53 gene.	Saccharin	74-90	tumor protein p53	Homo sapiens	128-131
30856053-2	2020	The present study aimed to evaluate the interaction of saccharin (SA) and sodium saccharin (SSA) with the promoter of the human p53 gene.	Saccharin	92-95	tumor protein p53	Homo sapiens	128-131
30856053-12	2020	This study could provide valuable insight into the binding mechanism of SA and its salt with p53 gene promoter as macromolecule at the molecular level in atomistic details.	Saccharin	72-74	tumor protein p53	Homo sapiens	93-96
31542636-12	2019	Similarly, ghrelin receptor knockout mice did not differ significantly from their wild-type littermates for auditory fear processing or anxiety-like behavior but showed significantly lower saccharin preference compared to wild-type littermates.	Saccharin	189-198	growth hormone secretagogue receptor	Mus musculus	11-27
31980728-5	2021	Selective deletion of AdipoR1 in 5-HT neurons induced anhedonia in male mice, as indicated by reduced female urine sniffing time and saccharin preference, and behavioral despair in female mice and enhanced stress-induced decrease in sucrose preference in both sexes.	Saccharin	133-142	adiponectin receptor 1	Mus musculus	22-29
31820979-1	2020	The first electrophilic asymmetric selenocyanation have been achieved in the presence of Ni(OTf)2 and (R,R)-DBFOX/Ph using N-selenocyanato saccharin as the new selenocyanation reagent.	Saccharin	123-148	POU class 2 homeobox 2	Homo sapiens	92-97
31542636-13	2019	CONCLUSION: Taken together, our data suggest that disruption of ghrelin receptor function per se does not affect fear or anxiety-like behavior but may decrease saccharin preference in mice.	Saccharin	160-169	growth hormone secretagogue receptor	Mus musculus	64-80
31319253-7	2019	Acesulfame-K and saccharin (~110 mug L-1) were partially removed in the treatment columns.	Saccharin	17-26	immunoglobulin kappa variable 1-16	Homo sapiens	37-40
29984872-7	2019	In contrast to ethanol, GAL3 -KO mice exhibited similar preference for saccharin and sucrose over water, and a similar preference for a high fat diet over a low fat diet as wildtype littermates.	Saccharin	71-80	lectin, galactose binding, soluble 3	Mus musculus	24-28
30928709-0	2019	Novel benzenesulfonamide and 1,2-benzisothiazol-3(2H)-one-1,1-dioxide derivatives as potential selective COX-2 inhibitors.	Saccharin	29-69	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	105-110
31070489-9	2019	The mGluR3-KO mice also showed normal sucrose and saccharin preference.	Saccharin	50-59	glutamate receptor, ionotropic, AMPA3 (alpha 3)	Mus musculus	4-10
30928709-1	2019	Two new series of 1,2-benzisothiazol-3(2H)-one-1,1-dioxide derivatives containing either five membered heterocyclic rings or aryl hydrazones were synthesized and evaluated for their in vitro COX-1/COX-2 inhibitory activity.	Saccharin	18-58	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	191-196
30928709-1	2019	Two new series of 1,2-benzisothiazol-3(2H)-one-1,1-dioxide derivatives containing either five membered heterocyclic rings or aryl hydrazones were synthesized and evaluated for their in vitro COX-1/COX-2 inhibitory activity.	Saccharin	18-58	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	197-202
30034596-2	2018	Recent studies have demonstrated the selectivity of sucrose, saccharin, and acesulfame potassium for CA IX over other CA isoforms.	Saccharin	61-70	carbonic anhydrase 9	Homo sapiens	101-106
30921738-2	2019	Simple cyclic sulfonamides, like saccharin (SAC), have shown up to a 60-fold selectivity towards CA IX over other ubiquitous CA isoforms, with greater selectivity obtained applying the "tail-approach" to derivatize SAC with a methylene triazole linker that connected to a "tail" beta glucoside.	Saccharin	33-42	carbonic anhydrase 9	Homo sapiens	97-102
29042247-4	2017	Whereas cumulative saccharin intake was reduced by DA D1 receptor antagonism in BALB/c and SWR mice, naltrexone was more potent in SWR relative to BALB/c mice.	Saccharin	19-28	dopamine receptor D1	Mus musculus	54-65
29266943-3	2018	Previously, saccharin, a commonly used artificial sweetener, has been observed to selectively inhibit CA IX over other CA isoforms.	Saccharin	12-21	carbonic anhydrase 9	Homo sapiens	102-107
28407474-7	2017	On the other hand, acesulfame-potassium (Ace-K) and saccharin have similar binding characteristics to each other but, while Ace-K may increase incretin secretion and glucose responses in humans, there are no data on saccharin except in rats, which show impaired glucose tolerance after chronic administration.	Saccharin	52-61	angiotensin I converting enzyme	Homo sapiens	124-127
28472674-8	2017	Elevated expression of pro-inflammatory iNOS and TNF-alpha in liver indicated that saccharin induced inflammation in mice.	Saccharin	83-92	nitric oxide synthase 2, inducible	Mus musculus	40-44
28472674-8	2017	Elevated expression of pro-inflammatory iNOS and TNF-alpha in liver indicated that saccharin induced inflammation in mice.	Saccharin	83-92	tumor necrosis factor	Mus musculus	49-58
26386270-9	2016	Compared to caged control rats, Arc expression was significantly higher in rats that consumed sucrose or saccharin.	Saccharin	105-114	activity-regulated cytoskeleton-associated protein	Rattus norvegicus	32-35
28498651-0	2017	Design of Benzoxathiazin-3-one 1,1-Dioxides as a New Class of Irreversible Serine Hydrolase Inhibitors: Discovery of a Uniquely Selective PNPLA4 Inhibitor.	Saccharin	31-43	patatin like phospholipase domain containing 4	Homo sapiens	138-144
26691867-6	2017	Finally, we found that a small molecule GLO1 inhibitor (S-bromobenzylglutathione cyclopentyl diester (pBBG; 6.25, 12.5 mg/kg)) reduced EtOH consumption compared to vehicle treated B6 mice without altering saccharin or water consumption.	Saccharin	205-214	glyoxalase 1	Mus musculus	40-44
27798822-5	2017	The kinetic isotope effects (KIEs) for the oxidation of (2R,3R)-[2-2 H1 ,3-2 H1 ]butane are 7.3 and 7.8 in BM3 PF and EPF, respectively; whereas KIEs for (2S,3S)-[2-2 H1 ,3-2 H1 ]butanes are 18 and 25 in BM3 PF and EPF, respectively.	Saccharin	154-161	heat shock protein family E (Hsp10) member 1	Homo sapiens	118-121
27683267-2	2016	Herein, we demonstrate that dose-response relationships existed with regard to administration of saccharin or sucrose to mice for 35 days, and this association involved testis-expressed sweet-tasting molecules (taste receptor type 1 subunit 3 [T1R3]; G protein alpha-gustducin [Galpha]).	Saccharin	97-106	taste receptor, type 1, member 3	Mus musculus	244-248
27683267-3	2016	Mouse body weights and testis weights in middle- and low-dose saccharin-treated groups were increased with up-expressions of molecules involved in testicular sweet taste and steroidogenic (middle saccharin: steroidogenic acute regulatory protein [StAR]; P450 cholesterol side-chain cleavage enzyme [CYP11A1]; 17-alpha-hydroxylase/C17,20-lyase [CYP17A1]; low saccharin: StAR).	Saccharin	62-71	steroidogenic acute regulatory protein	Mus musculus	247-251
27683267-3	2016	Mouse body weights and testis weights in middle- and low-dose saccharin-treated groups were increased with up-expressions of molecules involved in testicular sweet taste and steroidogenic (middle saccharin: steroidogenic acute regulatory protein [StAR]; P450 cholesterol side-chain cleavage enzyme [CYP11A1]; 17-alpha-hydroxylase/C17,20-lyase [CYP17A1]; low saccharin: StAR).	Saccharin	62-71	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	299-306
27683267-3	2016	Mouse body weights and testis weights in middle- and low-dose saccharin-treated groups were increased with up-expressions of molecules involved in testicular sweet taste and steroidogenic (middle saccharin: steroidogenic acute regulatory protein [StAR]; P450 cholesterol side-chain cleavage enzyme [CYP11A1]; 17-alpha-hydroxylase/C17,20-lyase [CYP17A1]; low saccharin: StAR).	Saccharin	62-71	cytochrome P450, family 17, subfamily a, polypeptide 1	Mus musculus	344-351
27683267-3	2016	Mouse body weights and testis weights in middle- and low-dose saccharin-treated groups were increased with up-expressions of molecules involved in testicular sweet taste and steroidogenic (middle saccharin: steroidogenic acute regulatory protein [StAR]; P450 cholesterol side-chain cleavage enzyme [CYP11A1]; 17-alpha-hydroxylase/C17,20-lyase [CYP17A1]; low saccharin: StAR).	Saccharin	62-71	steroidogenic acute regulatory protein	Mus musculus	369-373
27515532-12	2016	Amygdala AAV-TNF was without effect on body weight and aversive stimulus learning-memory, but reduced saccharin consumption and increased anxiety.	Saccharin	102-111	tumor necrosis factor	Mus musculus	13-16
27312406-5	2016	In turn, viral-mediated knockdown of MeCP2 expression in the NAc core reduces methamphetamine SA, as well as saccharin intake.	Saccharin	109-118	methyl CpG binding protein 2	Rattus norvegicus	37-42
28360094-4	2017	4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BPAM344) potentiated glutamate-evoked currents of GluK2a 21-fold at the highest concentration tested (200 muM), with an EC50 of 79 muM.	Saccharin	61-72	glutamate ionotropic receptor kainate type subunit 2	Homo sapiens	124-129
28360094-4	2017	4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BPAM344) potentiated glutamate-evoked currents of GluK2a 21-fold at the highest concentration tested (200 muM), with an EC50 of 79 muM.	Saccharin	61-72	latexin	Homo sapiens	180-183
28360094-4	2017	4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BPAM344) potentiated glutamate-evoked currents of GluK2a 21-fold at the highest concentration tested (200 muM), with an EC50 of 79 muM.	Saccharin	61-72	latexin	Homo sapiens	205-208
28472098-2	2017	Here, we show that stimulation of this receptor with sucralose or saccharin induced disassembly of the microtubules in 3T3-L1 preadipocytes, which was attenuated by overexpression of the dominant-negative mutant of Galphas (Galphas-G226A).	Saccharin	66-75	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	Mus musculus	215-222
28472098-2	2017	Here, we show that stimulation of this receptor with sucralose or saccharin induced disassembly of the microtubules in 3T3-L1 preadipocytes, which was attenuated by overexpression of the dominant-negative mutant of Galphas (Galphas-G226A).	Saccharin	66-75	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	Mus musculus	224-231
28323090-0	2017	c-Fos activity in the insular cortex, nucleus accumbens and basolateral amygdala following the intraperitoneal injection of saccharin and lithium chloride.	Saccharin	124-133	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-5
28323090-1	2017	This study examined c-Fos expression in selected brain areas consequent to intraperitoneal (IP) administration of saccharin and lithium chloride.	Saccharin	114-123	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	20-25
28146272-11	2017	MyD88 KO mice showed a slight reduction in preference for saccharin.	Saccharin	58-67	myeloid differentiation primary response gene 88	Mus musculus	0-5
27721153-3	2017	In vitro studies showed that the majority of saccharin derivatives with piperazine moiety and one phthalimide derivative with 3-aminopiperidine fragment exhibited inhibitory potency toward acetylcholinesterase (AChE) with EeAChE IC50 values ranging from 0.83 muM to 19.18 muM.	Saccharin	45-54	acetylcholinesterase (Cartwright blood group)	Homo sapiens	189-209
27721153-3	2017	In vitro studies showed that the majority of saccharin derivatives with piperazine moiety and one phthalimide derivative with 3-aminopiperidine fragment exhibited inhibitory potency toward acetylcholinesterase (AChE) with EeAChE IC50 values ranging from 0.83 muM to 19.18 muM.	Saccharin	45-54	acetylcholinesterase (Cartwright blood group)	Homo sapiens	211-215
27721153-3	2017	In vitro studies showed that the majority of saccharin derivatives with piperazine moiety and one phthalimide derivative with 3-aminopiperidine fragment exhibited inhibitory potency toward acetylcholinesterase (AChE) with EeAChE IC50 values ranging from 0.83 muM to 19.18 muM.	Saccharin	45-54	latexin	Homo sapiens	259-262
27721153-3	2017	In vitro studies showed that the majority of saccharin derivatives with piperazine moiety and one phthalimide derivative with 3-aminopiperidine fragment exhibited inhibitory potency toward acetylcholinesterase (AChE) with EeAChE IC50 values ranging from 0.83 muM to 19.18 muM.	Saccharin	45-54	latexin	Homo sapiens	272-275
28133510-4	2017	Here, we examined the effects of the potential saccharin-drug interaction on the activities of 5 cytochrome P450 (CYPs) in male ICR mice; further, we examined the effects of saccharin (4,000 mg/kg) on the pharmacokinetics of bupropion after pretreatment of mice with saccharin for 7 days and after concomitant administration of bupropion and saccharin.	Saccharin	47-56	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	97-112
27683267-4	2016	Moreover, a high-dose saccharin-related decline in reproductive hormone levels and injuries to testis and sperm were observed to be associated with suppression of testicular T1R3 and Galpha, as well as steroidogenic-related factors (StAR; 3-beta-hydroxysteroid dehydrogenase [3-beta-HSD]; CYP11A1; CYP17A1; 17-beta-hydroxysteroid dehydrogenase [17-beta-HSD]), and activation of cleaved caspase-3.	Saccharin	22-31	taste receptor, type 1, member 3	Mus musculus	174-189
27683267-4	2016	Moreover, a high-dose saccharin-related decline in reproductive hormone levels and injuries to testis and sperm were observed to be associated with suppression of testicular T1R3 and Galpha, as well as steroidogenic-related factors (StAR; 3-beta-hydroxysteroid dehydrogenase [3-beta-HSD]; CYP11A1; CYP17A1; 17-beta-hydroxysteroid dehydrogenase [17-beta-HSD]), and activation of cleaved caspase-3.	Saccharin	22-31	steroidogenic acute regulatory protein	Mus musculus	233-237
27683267-4	2016	Moreover, a high-dose saccharin-related decline in reproductive hormone levels and injuries to testis and sperm were observed to be associated with suppression of testicular T1R3 and Galpha, as well as steroidogenic-related factors (StAR; 3-beta-hydroxysteroid dehydrogenase [3-beta-HSD]; CYP11A1; CYP17A1; 17-beta-hydroxysteroid dehydrogenase [17-beta-HSD]), and activation of cleaved caspase-3.	Saccharin	22-31	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	289-296
27683267-4	2016	Moreover, a high-dose saccharin-related decline in reproductive hormone levels and injuries to testis and sperm were observed to be associated with suppression of testicular T1R3 and Galpha, as well as steroidogenic-related factors (StAR; 3-beta-hydroxysteroid dehydrogenase [3-beta-HSD]; CYP11A1; CYP17A1; 17-beta-hydroxysteroid dehydrogenase [17-beta-HSD]), and activation of cleaved caspase-3.	Saccharin	22-31	cytochrome P450, family 17, subfamily a, polypeptide 1	Mus musculus	298-305
27683267-4	2016	Moreover, a high-dose saccharin-related decline in reproductive hormone levels and injuries to testis and sperm were observed to be associated with suppression of testicular T1R3 and Galpha, as well as steroidogenic-related factors (StAR; 3-beta-hydroxysteroid dehydrogenase [3-beta-HSD]; CYP11A1; CYP17A1; 17-beta-hydroxysteroid dehydrogenase [17-beta-HSD]), and activation of cleaved caspase-3.	Saccharin	22-31	hydroxysteroid (17-beta) dehydrogenase 1	Mus musculus	307-343
27683267-4	2016	Moreover, a high-dose saccharin-related decline in reproductive hormone levels and injuries to testis and sperm were observed to be associated with suppression of testicular T1R3 and Galpha, as well as steroidogenic-related factors (StAR; 3-beta-hydroxysteroid dehydrogenase [3-beta-HSD]; CYP11A1; CYP17A1; 17-beta-hydroxysteroid dehydrogenase [17-beta-HSD]), and activation of cleaved caspase-3.	Saccharin	22-31	hydroxysteroid (17-beta) dehydrogenase 1	Mus musculus	345-356
27683267-6	2016	Collectively, our results clearly suggest that saccharin-induced physiologic effects on testis are associated with testicular T1R3 and Galpha, which differed from sucrose.	Saccharin	47-56	taste receptor, type 1, member 3	Mus musculus	126-141
27306084-8	2016	We also compared the consequence of OxtR modulation on the consumption and preference of saccharin and quinine and found that the two experimental groups did not differ for any tastant.	Saccharin	89-98	oxytocin receptor	Mus musculus	36-40
26032855-5	2015	Based on the results of the pharmacological evaluation, we identified compound 8b with a saccharine moiety as the most potent and selective human acetylcholinesterase inhibitor (IC50  = 33 nM) and beta amyloid aggregation inhibitor.	Saccharin	89-99	acetylcholinesterase (Cartwright blood group)	Homo sapiens	146-166
26651338-3	2015	Systemic application or microinjection of AVP into rat VN and rotatory stimulus were used to induce conditioned taste aversion (CTA) to 0.15 % saccharin sodium solution as a model of MS.	Saccharin	143-159	arginine vasopressin	Rattus norvegicus	42-45
26292268-4	2015	We observed reduced sucrose and saccharin consumption in Ghrelin KO vs Ghrelin WT mice.	Saccharin	32-41	ghrelin	Mus musculus	57-64
26131217-9	2015	Saccharin high dose induce a significant decline in hepatic GSH levels, catalase and SOD activities while increased in hepatic MDA level.	Saccharin	0-9	catalase	Rattus norvegicus	72-80
25540053-5	2015	Drug-free second-order conditioning training among Groups P/P and U/P then consisted of a 5 min intraoral infusion of 0.1 % saccharin (CS2) in the context (CS1), while Group P/U received saccharin in the home cage 24 hr prior to the CS1 exposure.	Saccharin	124-133	calsyntenin 2	Rattus norvegicus	135-138
26537649-0	2015	[Development of a New Method for Determination of Sodium Saccharin and Acesulfame Potassium with the Aid of Coagulant].	Saccharin	50-66	activation induced cytidine deaminase	Homo sapiens	101-104
24780894-8	2014	Glucose and saccharin were equally effective in reducing pCREB expression in the orexin neurons of female rats.	Saccharin	12-21	hypocretin neuropeptide precursor	Rattus norvegicus	81-87
24983661-3	2014	The present study evaluates from a pharmacological and a molecular approach the contribution of OX to excessive binge-like consumption of highly preferred palatable substances (sucrose and saccharin) in ad libitum-fed C57BL/6J mice.	Saccharin	189-198	hypocretin	Mus musculus	96-98
24983661-5	2014	(2) Four repetitive, 2-h daily episodes of sucrose and saccharin (but not water) binge-like drinking significantly dampened OX mRNA expression in the LH.	Saccharin	55-64	hypocretin	Mus musculus	124-126
24994857-4	2014	On postoperative day 11 (POD 11), rats received catheter infusions of saccharin [sweet taste receptor (T1R2/3) agonist] or saline (control).	Saccharin	70-79	taste 1 receptor member 3	Rattus norvegicus	103-109
22781839-4	2013	Using short hairpin RNA (shRNA)-expressing lentiviral vectors (LV) to alter locally the activity of mGluR7 in male rats, we have shown that blocking mGluR7 expression increased ethanol consumption and preference in a two-bottle choice drinking paradigm with no effect either on saccharin or on quinine used for taste discrimination.	Saccharin	278-287	glutamate receptor, ionotropic, kainate 3	Mus musculus	149-155
24689792-3	2014	However, saccharin, a cyclic secondary sulfonamide, has unusually good inhibition of CA IX (Ki = 103 nM).	Saccharin	9-18	carbonic anhydrase 9	Homo sapiens	85-90
23339426-0	2014	In vitro inhibition effect and structure-activity relationships of some saccharin derivatives on erythrocyte carbonic anhydrase I and II.	Saccharin	72-81	carbonic anhydrase 1	Homo sapiens	109-136
23339426-1	2014	In this study, in vitro inhibitory effects of some saccharin derivatives on purified carbonic anhydrase I and II were investigated using CO2 as a substrate.	Saccharin	51-60	carbonic anhydrase 1	Homo sapiens	85-112
22830647-2	2014	This study was designed to test the effect of the specific Orx/Hcrt receptor-1 (Hcrt-r1) antagonist, N-(2-methyl-6-benzoxazolyl)-N"-1,5-naphthyridin-4-yl urea (SB334867), on reinstatement elicited by ethanol (EtOH)-associated stimuli versus stimuli associated with a conventional reinforcer [i.e. SuperSac, consisting of 3% glucose and 0.125% saccharin (w/v)].	Saccharin	343-352	hypocretin receptor 1	Homo sapiens	59-78
24120730-2	2013	In the current study, we examined the effects of artificial sweeteners (aspartame, acesulfame, cyclamate, saccharin) on the aryl hydrocarbon receptor (AhR) and glucocorticoid receptor (GR)-dependent expression of CYP1A1 in human hepatocytes, hepatic HepG2 and intestinal LS174T cancer cell lines.	Saccharin	106-115	aryl hydrocarbon receptor	Homo sapiens	124-149
24120730-2	2013	In the current study, we examined the effects of artificial sweeteners (aspartame, acesulfame, cyclamate, saccharin) on the aryl hydrocarbon receptor (AhR) and glucocorticoid receptor (GR)-dependent expression of CYP1A1 in human hepatocytes, hepatic HepG2 and intestinal LS174T cancer cell lines.	Saccharin	106-115	aryl hydrocarbon receptor	Homo sapiens	151-154
24120730-2	2013	In the current study, we examined the effects of artificial sweeteners (aspartame, acesulfame, cyclamate, saccharin) on the aryl hydrocarbon receptor (AhR) and glucocorticoid receptor (GR)-dependent expression of CYP1A1 in human hepatocytes, hepatic HepG2 and intestinal LS174T cancer cell lines.	Saccharin	106-115	nuclear receptor subfamily 3 group C member 1	Homo sapiens	160-183
22479254-11	2012	Together, this study showed a strong and stable nicotine preference in CD-1 mice, which was induced by a short-term high concentration of saccharin in the drinking water.	Saccharin	138-147	CD1 antigen complex	Mus musculus	71-75
22901622-2	2012	To this end, displacement chromatography of two intrinsic fluorescent proteins, enhanced green fluorescent protein (eGFP) and red fluorescent protein (RFP), were developed using sodium saccharin (NaSac) as a displacer.	Saccharin	178-194	tripartite motif containing 27	Homo sapiens	126-149
22901622-2	2012	To this end, displacement chromatography of two intrinsic fluorescent proteins, enhanced green fluorescent protein (eGFP) and red fluorescent protein (RFP), were developed using sodium saccharin (NaSac) as a displacer.	Saccharin	178-194	tripartite motif containing 27	Homo sapiens	151-154
22641083-6	2012	Chemical stimulation by saccharin or capsaicin at the weaning stage also increased SNAP25 immunoreactivity in the insular or somatosensory cortical area, respectively.	Saccharin	24-33	synaptosomal-associated protein 25	Mus musculus	83-89
23554493-7	2013	Significantly, a 7 d protocol of daily ingestion of a 3% solution of saccharin, a noncaloric sweetener, induced synaptic GluA1 similarly to 25% sucrose ingestion.	Saccharin	69-78	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	121-126
23006866-9	2012	Vasopressin-deficient mothers tended to explore more the open arms of the plus maze, showed more preference for sucrose and saccharin and struggled more in the forced swim test, suggesting that they act as less depressive.	Saccharin	124-133	arginine vasopressin	Rattus norvegicus	0-11
22405689-2	2012	To gain more understanding of the neural basis of this phenomenon, the current study examined whether a novel taste (0.5% saccharin) supports a different pattern of c-Fos expression than the same taste when it is familiar.	Saccharin	122-131	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	165-170
22077416-0	2011	Hydroxylated analogues of ATP-sensitive potassium channel openers belonging to the group of 6- and/or 7-substituted 3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides: toward an improvement in sulfonylurea receptor 1 selectivity and metabolism stability.	Saccharin	159-171	ATP binding cassette subfamily C member 8	Homo sapiens	198-221
21958737-1	2011	3-(4-Bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide (5) was discovered as a new prototype for dual inhibitors of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX).	Saccharin	56-67	prostaglandin-endoperoxide synthase 2	Homo sapiens	129-145
21958737-1	2011	3-(4-Bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide (5) was discovered as a new prototype for dual inhibitors of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX).	Saccharin	56-67	prostaglandin-endoperoxide synthase 2	Homo sapiens	147-152
21958737-1	2011	3-(4-Bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide (5) was discovered as a new prototype for dual inhibitors of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX).	Saccharin	56-67	arachidonate 5-lipoxygenase	Homo sapiens	158-172
21958737-1	2011	3-(4-Bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide (5) was discovered as a new prototype for dual inhibitors of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX).	Saccharin	56-67	arachidonate 5-lipoxygenase	Homo sapiens	174-179
21964712-0	2011	c-Fos expression in rat brainstem following intake of sucrose or saccharin.	Saccharin	65-74	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-5
20853157-8	2011	As expected, saccharin consumption was highly associated with alcohol consumption; data from 7 lines (HAP 1, 2, and 3, LAP 1, 2, and 3, and cHAP) indicated a genetic correlation between 10% alcohol and 0.32% saccharin intake of 0.91.	Saccharin	13-22	torsin A interacting protein 1	Mus musculus	119-124
19302086-8	2009	The levels of voluntary ethanol or quinine consumption were similar in the GDNF HET and WT mice, however, a small but significant increase in saccharin intake was observed in the GDNF HET mice.	Saccharin	142-151	glial cell line derived neurotrophic factor	Mus musculus	179-183
20338074-6	2010	Here, we show that supplementation of piglets" feed with a combination of artificial sweeteners saccharin and neohesperidin dihydrochalcone enhances the expression of SGLT1 and intestinal glucose transport function.	Saccharin	96-105	solute carrier family 5 member 1	Homo sapiens	167-172
20515700-5	2010	RESULTS: In the single bottle tests, peripheral ghrelin consistently increased the consumption of saccharin, independently of availability of caloric food.	Saccharin	98-107	ghrelin	Mus musculus	48-55
20407284-2	2010	METHODS: Mice of the CD1 strain were conditioned by pairing ingestion of 0.15% saccharin solution with injection of LPS (100 mug/mouse) or poly I:C (6 mg/kg).	Saccharin	79-88	CD1 antigen complex	Mus musculus	21-24
20700536-2	2010	Mutant mice lacking OXT (OXT knockout) overconsume salty and sweet (i.e. sucrose, saccharin) solutions.	Saccharin	82-91	oxytocin	Mus musculus	25-28
20072781-8	2010	In contrast, mice lacking the alpha7 nAChR receptor subunit consumed significantly less ethanol than wild-type mice but consumed comparable amounts of water, saccharin, and quinine.	Saccharin	158-167	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	30-36
18762424-2	2008	(2S,3S)- and (2R,3R)-iodoreboxetine were prepared and biological testing against various mono-amine transporters showed these compounds to be potent and selective for NAT.	Saccharin	0-7	solute carrier family 6 member 2	Homo sapiens	167-170
18556090-7	2008	A significant increase of plasma insulin concentration was apparent after stimulation with sucrose and saccharin.	Saccharin	103-112	insulin	Homo sapiens	33-40
18479784-2	2009	Various derivatizations of the ester moiety in the parent compound led to a small library of derivatives (2R,3R and 2S,3S) which displayed interesting inhibitory activities towards the human tumor-associated isoform CA IX.	Saccharin	116-121	carbonic anhydrase 9	Homo sapiens	216-221
17911381-4	2007	Allelic variation of the Tas1r3 gene influenced taste responsiveness to nonnutritive sweeteners (saccharin, acesulfame-K, sucralose, SC-45647), sugars (sucrose, maltose, glucose, fructose), sugar alcohols (erythritol, sorbitol), and some amino acids (D-tryptophan, D-phenylalanine, L-proline).	Saccharin	97-106	taste receptor, type 1, member 3	Mus musculus	25-31
18396382-2	2008	Peroxysome proliferator-activated receptors (PPAR) contribute to wide physiological processes within the liver such as lipid/glucid metabolisms, inflammatory response, cell differenciation and cell cycle.	Saccharin	125-131	peroxisome proliferator activated receptor alpha	Homo sapiens	0-43
18396382-2	2008	Peroxysome proliferator-activated receptors (PPAR) contribute to wide physiological processes within the liver such as lipid/glucid metabolisms, inflammatory response, cell differenciation and cell cycle.	Saccharin	125-131	peroxisome proliferator activated receptor alpha	Homo sapiens	45-49
17167172-3	2007	RBP, purified from hen egg white, suppressed the sweetness of protein sweeteners such as thaumatin, monellin, and lysozyme, whereas it did not suppress the sweetness of low molecular weight sweeteners such as sucrose, glycine, D-phenylalanine, saccharin, cyclamate, aspartame, and stevioside.	Saccharin	244-253	riboflavin binding protein	Gallus gallus	0-3
17556859-2	2007	Ghrelin physiologically induces food intake and seems to alter lipid and glucid metabolism in several tissues such as adipose tissue and liver.	Saccharin	73-79	ghrelin and obestatin prepropeptide	Rattus norvegicus	0-7
14649902-0	2003	Asymmetric synthesis of anti-(2S,3S)- and syn-(2R,3S)-diaminobutanoic acid.	Saccharin	29-36	synemin	Homo sapiens	11-14
15897716-11	2005	RESULTS: Male KOR KO mice in preference tests with 12% alcohol consumed about half as much alcohol as wild-type (WT) or heterozygous (HET) mice, showed lower preference for saccharin (0.033% and 0.066%) and higher preference to quinine (0.1 mM) than WT mice.	Saccharin	173-182	opioid receptor, kappa 1	Mus musculus	14-17
16893299-5	2006	NPY significantly increased the number of meals initiated for water, 0.1% saccharin, and 1.0 M sucrose solutions, but meal size was only increased for 1.0 M sucrose.	Saccharin	74-83	neuropeptide Y	Homo sapiens	0-3
16494447-4	2006	Computational studies reveal that the energetic preference between the transition structures involving the s-cis-enamine and the s-trans-enamine is smaller for the pipecolic acid as compared to proline, yielding the (2S,3R)-anti and the (2S,3S)-syn Mannich product in nearly equal amounts.	Saccharin	237-243	synemin	Homo sapiens	245-248
16223680-8	2006	However, the TOC removal increased to 54% and 69% after 16 h of adsorption of saccharin pretreated by ultrasonication for 180 min under Ar and O2/N2 atmospheres, respectively.	Saccharin	78-87	immunoglobulin kappa variable 1D-39	Homo sapiens	143-148
16206828-0	2005	2,4,5-Triphenylisothiazol-3 (2H)-one 1,1-dioxides as inhibitors of human leukocyte elastase.	Saccharin	37-49	elastase, neutrophil expressed	Homo sapiens	73-91
15322260-6	2004	The effects of bupropion and enantiomers of hydroxybupropion on human nAChR subtypes indicate that the (2S,3S) isomer is more potent than the (2S,3R) isomer or racemic bupropion as an antagonist of alpha(4)beta(2) (functional IC(50) = 3.3 microM).	Saccharin	103-110	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	70-75
14999080-4	2004	For intakes and preferences, significant linkages to Tas1r3 were found for the sweeteners sucrose, saccharin, and D-phenylalanine but not glycine.	Saccharin	99-108	taste receptor, type 1, member 3	Mus musculus	53-59
14999080-5	2004	For chorda tympani responses, significant linkages to Tas1r3 were found for the sweeteners sucrose, saccharin, D-phenylalanine, D-tryptophan, and SC-45647 but not glycine, L-proline, L-alanine, or L-glutamine.	Saccharin	100-109	taste receptor, type 1, member 3	Mus musculus	54-60
12626647-3	2003	The beta 2 null mutants showed decreased consumption of saccharin and quinine, but not ethanol.	Saccharin	56-65	hemoglobin, beta adult minor chain	Mus musculus	4-10
12213059-4	2002	6-Chloro-3-(1-methylcyclobutyl)amino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide (54) was found to bind and activate the SUR1/Kir6.2 K(ATP) channels in the low nanomolar range and to be at least 1000 times more potent than the reference compound diazoxide with respect to inhibition of insulin release from rat islets.	Saccharin	72-83	ATP binding cassette subfamily C member 8	Rattus norvegicus	124-128
12213059-1	2002	6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives were synthesized and characterized as activators of adenosine 5"-triphosphate (ATP) sensitive potassium (K(ATP)) channels in the beta-cells by measuring effects on membrane potential and insulin release in vitro.	Saccharin	57-68	insulin	Homo sapiens	268-275
12213059-4	2002	6-Chloro-3-(1-methylcyclobutyl)amino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide (54) was found to bind and activate the SUR1/Kir6.2 K(ATP) channels in the low nanomolar range and to be at least 1000 times more potent than the reference compound diazoxide with respect to inhibition of insulin release from rat islets.	Saccharin	72-83	potassium inwardly-rectifying channel, subfamily J, member 11	Rattus norvegicus	129-135
12213059-4	2002	6-Chloro-3-(1-methylcyclobutyl)amino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide (54) was found to bind and activate the SUR1/Kir6.2 K(ATP) channels in the low nanomolar range and to be at least 1000 times more potent than the reference compound diazoxide with respect to inhibition of insulin release from rat islets.	Saccharin	72-83	insulin	Homo sapiens	289-296
12217932-5	2002	RESULTS: After LiCl injections, saccharin consumption declined 21.6% in female Sprague-Dawley, 9.5% in female mHEP, 33.3% in male Wistar, and 38.3% in male mHEP rats.	Saccharin	32-41	histocompatibility 51	Mus musculus	110-114
10400348-10	1999	The inactivation process is enhanced in the presence of cofactor Mg2+ ions and Cys-361 appears to serve as a base for the removal of the C-3 proton from the natural substrate, (2S,3S)-3-methylaspartic acid.	Saccharin	176-183	complement C3	Homo sapiens	137-140
11767459-4	2001	The opposite effects of two doses of IL-1 beta were observed also in a test with saccharine.	Saccharin	81-91	interleukin 1 beta	Rattus norvegicus	37-46
12113887-0	2002	A convenient synthesis by microwave heating and pharmacological evaluation of novel benzoyltriazole and saccharine derivatives as 5-HT(1A) receptor ligands.	Saccharin	104-114	5-hydroxytryptamine receptor 1A	Homo sapiens	130-147
11704264-4	2001	DBI suppressed the intake of 5% sucrose, water and 0.9 mM quinine-HCl and the preference for 0.05% saccharin.	Saccharin	99-108	diazepam binding inhibitor	Mus musculus	0-3
11704264-7	2001	antagonized the suppressive effect of DBI on the intake and the preference for saccharin.	Saccharin	79-88	diazepam binding inhibitor	Mus musculus	38-41
9462845-2	1998	With an unequivocal (2S,3S) configuration this new trans-epoxysuccinyl peptide derivative was found to inhibit cathepsin B with an apparent second-order rate constant of 1,520,000 M(-1) s(-1) which represents so far the most potent inhibitor among E-64-derived compounds.	Saccharin	21-26	cathepsin B	Homo sapiens	111-122
9877410-7	1998	Saccharin consumption in all leptin treatments was not significantly different from the negative control.	Saccharin	0-9	leptin	Rattus norvegicus	29-35
9822554-0	1998	1,2-Benzisothiazol-3-one 1,1-dioxide inhibitors of human mast cell tryptase.	Saccharin	25-36	tryptase delta 1	Homo sapiens	57-75
8946502-1	1996	Intraoral infusions of sucrose or saccharin induce c-Fos-like immunoreactivity (c-FLI) in the intermediate nucleus of the solitary tract (iNTS) of rats after acquisition of a conditioned taste aversion (CTA).	Saccharin	34-43	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	51-56
10197356-1	1998	The present work demonstrates that the high-activity zinc metalloenzyme, carbonic anhydrase (CA II) from bovine erythrocytes is inhibited by the cyclic sulfimide, saccharin, and 2- and 4-carbobenzoxybenzene sulfonamide.	Saccharin	163-172	carbonic anhydrase 2	Bos taurus	93-98
9159506-1	1997	Expression of proto-oncogene c-fos was immunohistochemically examined in the central and basolateral amygdaloid nuclei in rats after ingestion of taste solutions (0.5 M sucrose or 0.005 M saccharin), intragastric infusion of these solutions, or an intraperitoneal injection of malaise-inducing lithium chloride (LiCl).	Saccharin	188-197	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-34
9650819-6	1997	IL-1beta, administered into both locations, induced a comparable suppression of motor activity, reduction in food and saccharine consumption, and loss of body weight.	Saccharin	118-128	interleukin 1 beta	Rattus norvegicus	0-8
9164554-6	1997	In subsequent generalization tests, doses of CCK that were ineffective in suppressing saccharin consumption (i.e., did not substitute for the training dose of CCK) did result in the suppression of saccharin consumption when combined with doses of the mu antagonist naloxone that alone had no effect on saccharin intake.	Saccharin	197-206	cholecystokinin	Rattus norvegicus	45-48
9164554-6	1997	In subsequent generalization tests, doses of CCK that were ineffective in suppressing saccharin consumption (i.e., did not substitute for the training dose of CCK) did result in the suppression of saccharin consumption when combined with doses of the mu antagonist naloxone that alone had no effect on saccharin intake.	Saccharin	197-206	cholecystokinin	Rattus norvegicus	45-48
8833104-8	1996	The control experiments revealed that 6 h after LiCl injection alone (without previous saccharin consumption) translocation of PKC from the cytosol to the membrane fraction (found previously 1 h after LiCl injection alone) still persisted but did not differ from that found 6 h after its pairing with saccharin drinking (CTA).	Saccharin	87-96	protein kinase C, gamma	Rattus norvegicus	127-130
8806743-0	1996	Amino acid-derived phthalimide and saccharin derivatives as inhibitors of human leukocyte elastase, cathepsin G, and proteinase 3.	Saccharin	35-44	elastase, neutrophil expressed	Homo sapiens	80-98
8806743-0	1996	Amino acid-derived phthalimide and saccharin derivatives as inhibitors of human leukocyte elastase, cathepsin G, and proteinase 3.	Saccharin	35-44	cathepsin G	Homo sapiens	100-111
8806743-0	1996	Amino acid-derived phthalimide and saccharin derivatives as inhibitors of human leukocyte elastase, cathepsin G, and proteinase 3.	Saccharin	35-44	proteinase 3	Homo sapiens	117-129
12226358-3	1996	With the same treatment, protease activity in the cell, which was measured at pH 5.0 using fluorescein thiocarbamoyl-casein as a substrate, increased 3- to 7-fold after 1 d. When the cysteine protease inhibitor (2S,3S)-trans-epoxysuccinyl-L-leucylamido-3-methyl-butane (10 [mu]M) was present in the starvation medium, both the protein degradation and the increase in the protease activity were effectively inhibited.	Saccharin	212-217	senescence-specific cysteine protease SAG12-like	Nicotiana tabacum	183-200
8603385-0	1996	Effects of sodium saccharin and linoleic acid on mRNA levels of Her2/neu and p53 in a human breast epithelial cell line.	Saccharin	11-27	erb-b2 receptor tyrosine kinase 2	Homo sapiens	64-72
8603385-0	1996	Effects of sodium saccharin and linoleic acid on mRNA levels of Her2/neu and p53 in a human breast epithelial cell line.	Saccharin	11-27	tumor protein p53	Homo sapiens	77-80
8603385-1	1996	The effects of two food-related chemicals (sodium saccharin and linoleic acid) on the levels of Her2/neu and p53 mRNA in a non-cancerous human breast epithelial cell line (HBL-100) were tested in comparison with the effects of the known tumor promoter phorbol 12-myristate 13-acetate (TPA).	Saccharin	43-59	erb-b2 receptor tyrosine kinase 2	Homo sapiens	96-104
8603385-1	1996	The effects of two food-related chemicals (sodium saccharin and linoleic acid) on the levels of Her2/neu and p53 mRNA in a non-cancerous human breast epithelial cell line (HBL-100) were tested in comparison with the effects of the known tumor promoter phorbol 12-myristate 13-acetate (TPA).	Saccharin	43-59	tumor protein p53	Homo sapiens	109-112
8603385-3	1996	The effects in general were small, the greatest being increases of 46-67% in Her2/neu mRNA levels in response to treatments with TPA or sodium saccharin following NMU treatments.	Saccharin	136-152	erb-b2 receptor tyrosine kinase 2	Homo sapiens	77-85
8603385-4	1996	These results demonstrate that sodium saccharin following NMU treatments might be involved in transcriptional regulation of Her2/neu in HBL-100 cells and suggest that its effects may not be limited to urinary bladder.	Saccharin	31-47	erb-b2 receptor tyrosine kinase 2	Homo sapiens	124-132
8894097-2	1996	The results of this study revealed that (a) inhibitory activity is dependent on the nature and pKa of the leaving group, and (b) the synthesized saccharin derivatives exhibit selective inhibition toward HLE and PR 3, with low or no activity toward cathepsin G.	Saccharin	145-154	elastase, neutrophil expressed	Homo sapiens	203-206
8894097-2	1996	The results of this study revealed that (a) inhibitory activity is dependent on the nature and pKa of the leaving group, and (b) the synthesized saccharin derivatives exhibit selective inhibition toward HLE and PR 3, with low or no activity toward cathepsin G.	Saccharin	145-154	proteinase 3	Homo sapiens	211-215
8833104-8	1996	The control experiments revealed that 6 h after LiCl injection alone (without previous saccharin consumption) translocation of PKC from the cytosol to the membrane fraction (found previously 1 h after LiCl injection alone) still persisted but did not differ from that found 6 h after its pairing with saccharin drinking (CTA).	Saccharin	301-310	protein kinase C, gamma	Rattus norvegicus	127-130
8742472-1	1995	We have used in situ hybridization to investigate the modulation of expression of the immediate early genes (IEGs) c-fos, fos-B, zif/268 and CREM in rat brain following oral administration of saccharin, i.p.	Saccharin	192-201	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	115-120
8742472-1	1995	We have used in situ hybridization to investigate the modulation of expression of the immediate early genes (IEGs) c-fos, fos-B, zif/268 and CREM in rat brain following oral administration of saccharin, i.p.	Saccharin	192-201	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	122-127
8742472-1	1995	We have used in situ hybridization to investigate the modulation of expression of the immediate early genes (IEGs) c-fos, fos-B, zif/268 and CREM in rat brain following oral administration of saccharin, i.p.	Saccharin	192-201	early growth response 1	Rattus norvegicus	129-136
8742472-1	1995	We have used in situ hybridization to investigate the modulation of expression of the immediate early genes (IEGs) c-fos, fos-B, zif/268 and CREM in rat brain following oral administration of saccharin, i.p.	Saccharin	192-201	cAMP responsive element modulator	Rattus norvegicus	141-145
8230105-0	1993	Efficient inhibition of human leukocyte elastase and cathepsin G by saccharin derivatives.	Saccharin	68-77	cathepsin G	Homo sapiens	53-64
7671231-2	1995	Sodium saccharin-induced mutagenicity is detectable in human RSa cells by estimation of cloning efficiency of ouabain-resistant mutant cells and determination of K-ras codon 12 mutation in genomic DNA, analyzed by PCR and differential dot-blot hybridization.	Saccharin	0-16	KRAS proto-oncogene, GTPase	Homo sapiens	162-167
7796053-0	1995	The Gabriel-Colman rearrangement in biological systems: design, synthesis and biological evaluation of phthalimide and saccharin derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3.	Saccharin	119-128	elastase, neutrophil expressed	Homo sapiens	190-208
7796053-0	1995	The Gabriel-Colman rearrangement in biological systems: design, synthesis and biological evaluation of phthalimide and saccharin derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3.	Saccharin	119-128	cathepsin G	Homo sapiens	210-238
7796053-1	1995	The results of a structure-activity relationship study focusing on the interaction of a series of phthalimide and saccharin derivatives with leukocyte elastase, cathepsin G and proteinase 3 are described.	Saccharin	114-123	elastase, neutrophil expressed	Homo sapiens	141-159
7796053-1	1995	The results of a structure-activity relationship study focusing on the interaction of a series of phthalimide and saccharin derivatives with leukocyte elastase, cathepsin G and proteinase 3 are described.	Saccharin	114-123	cathepsin G	Homo sapiens	161-172
7796053-1	1995	The results of a structure-activity relationship study focusing on the interaction of a series of phthalimide and saccharin derivatives with leukocyte elastase, cathepsin G and proteinase 3 are described.	Saccharin	114-123	proteinase 3	Homo sapiens	177-189
8062216-2	1994	We investigated the steady state level of prohibitin mRNA in rat bladder cell lines and in rat bladder carcinoma induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) and sodium saccharin, as well as the protein level in rat bladder epithelial cells.	Saccharin	181-197	prohibitin 1	Rattus norvegicus	42-52
7972306-8	1994	Application of NaF (20 mM) for 4 min as a rinse significantly enhanced all of the sweet compounds by at least 23%, except for 10 mM sodium saccharin and 6.5 mM D-tryptophan, while all control compounds were suppressed.	Saccharin	132-148	C-X-C motif chemokine ligand 8	Homo sapiens	15-18
8240373-0	1993	Detection of K-ras codon 12 mutation by polymerase chain reaction and differential dot-blot hybridization in sodium saccharin-treated human RSA cell.	Saccharin	109-125	KRAS proto-oncogene, GTPase	Homo sapiens	13-18
8240373-1	1993	Using polymerase chain reaction and differential dot-blot hybridization, point mutations of K-ras codon 12 were investigated in hyper-mutable human RSa cells treated with sodium saccharin.	Saccharin	171-187	KRAS proto-oncogene, GTPase	Homo sapiens	92-97
8240373-3	1993	Results imply that sodium saccharin is a mutagen which induces genetic mutation and, furthermore, that the assay system applied here will be beneficial in identifying mutagen-induced K-ras oncogene mutations in human cells in vitro.	Saccharin	19-35	KRAS proto-oncogene, GTPase	Homo sapiens	183-188
8230105-1	1993	A series of saccharin derivatives I has been synthesized and evaluated for their inhibitory activity toward human leukocyte elastase and cathepsin G.	Saccharin	12-21	cathepsin G	Homo sapiens	137-148
24759185-6	2014	Among five different taste ligands (saccharin, Na-glutamate, NaCl, denatonium benzoate, HCl), only denatonium benzoate and HCl induced the release of CCK in STC-1 cells.	Saccharin	36-45	cholecystokinin	Homo sapiens	150-153
1325661-1	1992	A series of cyclic imides, which possess a bulkier N-ring structure than phthalimide and saccharin, were shown to suppress LDL receptor binding, internalization and degradation of isolated rat hepatocytes, foam cells, human fibroblasts and mouse macrophages.	Saccharin	89-98	low density lipoprotein receptor	Rattus norvegicus	123-135
1884376-3	1991	Focal reactivity to the ras p21 antibody was frequently observed in the hyperplastic (57-96%) or normal appearing urinary bladder epithelium (50-100%) in rats treated with FANFT (FANFT alone or in combination with sodium saccharin or tryptophan) but not in hyperplasia or normal epithelium in rats given sodium saccharin or tryptophan alone, without pretreatment with FANFT or in untreated controls.	Saccharin	214-230	KRAS proto-oncogene, GTPase	Rattus norvegicus	28-31
1884376-3	1991	Focal reactivity to the ras p21 antibody was frequently observed in the hyperplastic (57-96%) or normal appearing urinary bladder epithelium (50-100%) in rats treated with FANFT (FANFT alone or in combination with sodium saccharin or tryptophan) but not in hyperplasia or normal epithelium in rats given sodium saccharin or tryptophan alone, without pretreatment with FANFT or in untreated controls.	Saccharin	304-320	KRAS proto-oncogene, GTPase	Rattus norvegicus	28-31
2054786-0	1991	H-ras mutations in rat urinary bladder carcinomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and sodium saccharin, sodium ascorbate, or related salts.	Saccharin	110-126	HRas proto-oncogene, GTPase	Rattus norvegicus	0-5
8387656-6	1993	c-fos immunoreactivity studies showed that ingestion of saccharin induced a remarkable activation of the central lateral (cl) subnucleus of the PBN in normal rats, however, rats with the CTA to saccharin showed c-fos neurons in the ventral lateral (vl) subnucleus of the PBN.	Saccharin	56-65	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-5
8387656-6	1993	c-fos immunoreactivity studies showed that ingestion of saccharin induced a remarkable activation of the central lateral (cl) subnucleus of the PBN in normal rats, however, rats with the CTA to saccharin showed c-fos neurons in the ventral lateral (vl) subnucleus of the PBN.	Saccharin	56-65	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	211-216
1888328-9	1991	The hydration pattern of (2S,3S)- and (2R,3R)-2,3-epoxy-3-(4- nitrophenyl)glycidol by cytosolic epoxide hydrolase also differed.	Saccharin	25-32	epoxide hydrolase 2, cytoplasmic	Mus musculus	86-113
2326345-9	1990	The sugar-fat mixture was preferred to the saccharin-fat mixture, which in turn was preferred to the plain-fat emulsion.	Saccharin	43-52	FAT atypical cadherin 1	Rattus norvegicus	53-56
2326345-9	1990	The sugar-fat mixture was preferred to the saccharin-fat mixture, which in turn was preferred to the plain-fat emulsion.	Saccharin	43-52	FAT atypical cadherin 1	Rattus norvegicus	53-56
34803124-4	2021	Here, we show that stimulation of T1R3 with sucralose or saccharin induces microtubule disassembly in differentiated 3T3-L1 adipocytes.	Saccharin	57-66	taste receptor, type 1, member 3	Mus musculus	34-38
15337684-6	2004	hT2R61 is activated by 6-nitrosaccharin, a bitter derivative of saccharin.	Saccharin	30-39	taste 2 receptor member 38	Homo sapiens	0-6
35484599-1	2022	Saccharin is a cyclic secondary sulfonamide, which is a selective inhibitor of the tumor-associated carbonic anhydrase (CA; EC 4.2.1.1) enzymes CA IX and CA XII compared to many primary sulfonamides.	Saccharin	0-9	carbonic anhydrase 12	Homo sapiens	154-160
34729701-2	2021	METHODS: ADD was cocrystallized with three small molecules (i.e., paracetamol (PA), saccharin (SAC) and nicotinamide (NIC)), respectively.	Saccharin	84-93	adenylate cyclase 10	Rattus norvegicus	95-98
34444906-5	2021	The aim of this study was therefore to assess the effects of aspartame, saccharin, and sucralose on VEGF-induced leak using an in vitro model of the glomerular endothelium.	Saccharin	72-81	vascular endothelial growth factor A	Homo sapiens	100-104
34444906-6	2021	Saccharin and sucralose but not aspartame protected against VEGF-induced permeability.	Saccharin	0-9	vascular endothelial growth factor A	Homo sapiens	60-64
35598544-0	2022	Effect of saccharin, a non-nutritive sweeteners, on insulin and blood glucose levels in healthy young men: A crossover trial.	Saccharin	10-19	insulin	Homo sapiens	52-59